

                                 SEQUENCE LISTING
                       

      <110> Tang, Y. Tom
        Ren, Feiyan
        Zhang, Jie
        Zhao, Qing A.
        Wang, Jian-Rui
        Xue, Aidong J.
        Wang, Dunrui
        Ghosh, Malabika
        Asundi, Vinod
        Wehrman, Tom
        Zhou, Ping
        Goodrich, Ryle W.
        Weng, Gezhi
        Haley-Vicente, Dana
        Drmanac, Radoje T

      <120> Novel Nucleic Acids and 
        Polypeptides



      <130> 809ACIP PCT

	<140> To Be Assigned
	<141>	2002-09-19

      <150> US 60/323,739
      <151> 2001-09-19

      <150> US 09/488,725
      <151> 2000-01-21

      <150> US 09/552,317
      <151> 2000-04-25

      <150> PCT/US00/35017
      <151> 2000-12-22

      <150> US 09/491,404
      <151> 2000-01-25

      <150> PCT/US01/02623
      <151> 2001-01-25

      <150> US 09/496,914
      <151> 2000-02-03

      <150> US 09/560,875
      <151> 2000-04-27

      <150> PCT/US01/03800
      <151> 2001-02-05

      <150> US 09/515,126
      <151> 2000-02-28

      <150> US 09/577,409
      <151> 2000-05-18

      <150> PCT/US01/04927
      <151> 2001-02-26

      <150> US 09/519,705
      <151> 2000-03-07

      <150> US 09/574,454
      <151> 2000-05-19

      <150> PCT/US01/04941
      <151> 2001-03-05

      <150> US 09/540,217
      <151> 2000-03-31

      <150> US 09/649,167
      <151> 2000-08-23

      <150> PCT/US01/08631
      <151> 2001-03-30

      <150> US 09/552,929
      <151> 2000-04-18

      <150> US 09/770,160
      <151> 2001-01-26

      <150> PCT/US01/08656
      <151> 2001-04-18

      <150> US 09/577,408
      <151> 2000-05-18

      <150> PCT/US01/14827
      <151> 2001-05-16


      <160> 992

      <170> pt_FL_genes Version 6.0




      <210> 1
      <211> 2314
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1243)

      <400> 1
 cggcacgagc gtccctgcta gtactccggg ctgtgggggt cggtgcggat attcagtcat     60

 gaaatcaggg tagggacttc tcccgcagcg acgcggctgg caagactgtt tgtgttgcgg    120

 gggccggact tcaaggtgat tttacaacga g   atg ctg ctc tcc ata ggg atg     172
                                      Met Leu Leu Ser Ile Gly Met
                                        1               5

 ctc atg ctg tca gcc aca caa gtc tac acc atc ttg act gtc cag ctc      220
 Leu Met Leu Ser Ala Thr Gln Val Tyr Thr Ile Leu Thr Val Gln Leu
          10                  15                  20

 ttt gca ttc tta aac cta ctg cct gta gaa gca gac att tta gca tat      268
 Phe Ala Phe Leu Asn Leu Leu Pro Val Glu Ala Asp Ile Leu Ala Tyr
      25                  30                  35

 aac ttt gaa aat gca tct cag aca ttt gat gac ctc cct gca aga ttt      316
 Asn Phe Glu Asn Ala Ser Gln Thr Phe Asp Asp Leu Pro Ala Arg Phe
  40                  45                  50                  55

 ggt tat aga ctt cca gct gaa ggt tta aag ggt ttt ttg att aac tca      364
 Gly Tyr Arg Leu Pro Ala Glu Gly Leu Lys Gly Phe Leu Ile Asn Ser
                  60                  65                  70

 aaa cca gag aat gcc tgt gaa ccc ata gtg cct cca cca gtt ttt gat      412
 Lys Pro Glu Asn Ala Cys Glu Pro Ile Val Pro Pro Pro Val Phe Asp
              75                  80                  85

 ata aag gtt tta aat gca cag aga gca gga tac aag gca gcc ata gtt      460
 Ile Lys Val Leu Asn Ala Gln Arg Ala Gly Tyr Lys Ala Ala Ile Val
          90                  95                 100

 cac aat gtt gat tct gat gac ctc att agc atg gga tcc aac gac att      508
 His Asn Val Asp Ser Asp Asp Leu Ile Ser Met Gly Ser Asn Asp Ile
     105                 110                 115

 gag gta cta aag aaa att gac att cca tct gtc ttt att ggt gaa tca      556
 Glu Val Leu Lys Lys Ile Asp Ile Pro Ser Val Phe Ile Gly Glu Ser
 120                 125                 130                 135

 tca gct aat tct ctg aaa gat gaa ttc aca tat gaa aaa ggg ggc cac      604
 Ser Ala Asn Ser Leu Lys Asp Glu Phe Thr Tyr Glu Lys Gly Gly His
                 140                 145                 150

 ctt atc tta gtt cca gaa ttt agt ctt cct ttg gaa tac tac cta att      652
 Leu Ile Leu Val Pro Glu Phe Ser Leu Pro Leu Glu Tyr Tyr Leu Ile
             155                 160                 165

 ccc ttc ctt atc ata gtg ggc atc tgt ctc atc ttg ata gtc att ttc      700
 Pro Phe Leu Ile Ile Val Gly Ile Cys Leu Ile Leu Ile Val Ile Phe
         170                 175                 180

 atg atc aca aaa ttt gtc cag gat aga cat aga gct aga aga aac aga      748
 Met Ile Thr Lys Phe Val Gln Asp Arg His Arg Ala Arg Arg Asn Arg
     185                 190                 195

 ctt cgt aaa gat caa ctt aag aaa ctt cct gta cat aaa ttc aag aaa      796
 Leu Arg Lys Asp Gln Leu Lys Lys Leu Pro Val His Lys Phe Lys Lys
 200                 205                 210                 215

 gga gat gag tat gat gta tgt gcc att tgt ttg gat gag tat gaa gat      844
 Gly Asp Glu Tyr Asp Val Cys Ala Ile Cys Leu Asp Glu Tyr Glu Asp
                 220                 225                 230

 gga gac aaa ctc aga atc ctt ccc tgt tcc cat gct tat cat tgc aag      892
 Gly Asp Lys Leu Arg Ile Leu Pro Cys Ser His Ala Tyr His Cys Lys
             235                 240                 245

 tgt gta gac cct tgg cta act aaa acc aaa aaa acc tgt cca gtg tgc      940
 Cys Val Asp Pro Trp Leu Thr Lys Thr Lys Lys Thr Cys Pro Val Cys
         250                 255                 260

 aag caa aaa gtt gtt cct tct caa ggc gat tca gac tct gac aca gac      988
 Lys Gln Lys Val Val Pro Ser Gln Gly Asp Ser Asp Ser Asp Thr Asp
     265                 270                 275

 agt agt caa gaa gaa aat gaa gtg aca gaa cat acc cct tta ctg aga     1036
 Ser Ser Gln Glu Glu Asn Glu Val Thr Glu His Thr Pro Leu Leu Arg
 280                 285                 290                 295

 cct tta gct tct gtc agt gcc cag tca ttt ggg gct tta tcg gaa tcc     1084
 Pro Leu Ala Ser Val Ser Ala Gln Ser Phe Gly Ala Leu Ser Glu Ser
                 300                 305                 310

 cgc tca cat cag aac atg aca gaa tct tca gac tat gag gaa gac gac     1132
 Arg Ser His Gln Asn Met Thr Glu Ser Ser Asp Tyr Glu Glu Asp Asp
             315                 320                 325

 aat gaa gat act gac agt agt gat gca gaa aat gaa att aat gaa cat     1180
 Asn Glu Asp Thr Asp Ser Ser Asp Ala Glu Asn Glu Ile Asn Glu His
         330                 335                 340

 gat gtc gtg gtc cag ttg cag cct aat ggt gaa cgg gat tac aac ata     1228
 Asp Val Val Val Gln Leu Gln Pro Asn Gly Glu Arg Asp Tyr Asn Ile
     345                 350                 355

 gca aat act gtt tga ctttcagaag atgattggtt tatttccctt taaaatgatt     1283
 Ala Asn Thr Val 
 360

 aggtatatac tgtaatttga ttttttgctc ccttcaaaga tttctgtaga aataacttat   1343

 tttttagtat tctacagttt aatcaaatta ctgaaacagg acttttgatc tggtatttat   1403

 ctgccaagaa tatacttcat tcactaataa tagactggtg ctgtaactca agcatcaatt   1463

 cagctcttct tttggaatga aagtatagcc aaaacataaa aaaaaaaaaa tcctcagtat   1523

 agcttgcaat taagacctag atcacagtat ttaagtgttt tgcgttttat acatgaggtc   1583

 agtgctacag ccacctagca tgaactaacc cagcttccac ctccataaag ttacctagag   1643

 ttgttgagtt ggaatatgtt ctggcattta cctgacctgc caatcattag ggagaggcaa   1703

 caaggtaatt cagcctttcc tcctatcagc acaaagaaac tcaaagctgt tttttccctt   1763

 tctgttccaa agcagtctta tcctgacagg agcggtctat actagtgcag atttcaacac   1823

 ttttttttaa cgttttaatt actatagtgt tatgtagaga tttgattgag cagctaatgt   1883

 ttctgaactt tacttactaa ttttcagtgt ccttaagggt tctgtagtgt tatcaaagca   1943

 aaaagaaaat gctgcataaa aataccaaac ttcagcaact gttaatactc agatcatata   2003

 cctcttaata aatagcatct tatgctaatt agccctgcta aactatgtac agaggaaact   2063

 gttcaagtat tggatttgaa agtaagtgac ttatgtttaa cagaactaat gatgtattga   2123

 aacactgtat tatgaaaagc taaattatac atcattgtaa ctatgtagaa agtgtagact   2183

 aatgtataat caaaatgcta aggattttta tatggccttg tatgagggga gtttgaatgt   2243

 taataaacat gttttccact ttaagatcca gtaaatgtct gttctactgt agtattactt   2303

 aaaaaaaaaa a                                                        2314




      <210> 2
      <211> 2242
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1171)

      <400> 2
 cggcacgagc gtccctgcta gtactccggg ctgtgggggt cggtgcggat attcagtcat     60

 gaaatcaggg tagggacttc tcccgcagcg acgcggctgg caagactgtt tgtgttgcgg    120

 gggccggact tcaaggtgat tttacaacga g   atg ctg ctc tcc ata ggg atg     172
                                      Met Leu Leu Ser Ile Gly Met
                                        1               5

 ctc atg ctg tca gcc aca caa gtc tac acc atc ttg act gtc cag ctc      220
 Leu Met Leu Ser Ala Thr Gln Val Tyr Thr Ile Leu Thr Val Gln Leu
          10                  15                  20

 ttt gca ttc tta aac cta ctg cct gta gaa gca gac att tta gca tat      268
 Phe Ala Phe Leu Asn Leu Leu Pro Val Glu Ala Asp Ile Leu Ala Tyr
      25                  30                  35

 aac ttt gaa aat gca tct cag aca ttt gat gac ctc cct gca aga ttt      316
 Asn Phe Glu Asn Ala Ser Gln Thr Phe Asp Asp Leu Pro Ala Arg Phe
  40                  45                  50                  55

 ggt tat aga ctt cca gct gaa ggt tta aag gtt tta aat gca cag aga      364
 Gly Tyr Arg Leu Pro Ala Glu Gly Leu Lys Val Leu Asn Ala Gln Arg
                  60                  65                  70

 gca gga tac aag gca gcc ata gtt cac aat gtt gat tct gat gac ctc      412
 Ala Gly Tyr Lys Ala Ala Ile Val His Asn Val Asp Ser Asp Asp Leu
              75                  80                  85

 att agc atg gga tcc aac gac att gag gta cta aag aaa att gac att      460
 Ile Ser Met Gly Ser Asn Asp Ile Glu Val Leu Lys Lys Ile Asp Ile
          90                  95                 100

 cca tct gtc ttt att ggt gaa tca tca gct aat tct ctg aaa gat gaa      508
 Pro Ser Val Phe Ile Gly Glu Ser Ser Ala Asn Ser Leu Lys Asp Glu
     105                 110                 115

 ttc aca tat gaa aaa ggg ggc cac ctt atc tta gtt cca gaa ttt agt      556
 Phe Thr Tyr Glu Lys Gly Gly His Leu Ile Leu Val Pro Glu Phe Ser
 120                 125                 130                 135

 ctt cct ttg gaa tac tac cta att ccc ttc ctt atc ata gtg ggc atc      604
 Leu Pro Leu Glu Tyr Tyr Leu Ile Pro Phe Leu Ile Ile Val Gly Ile
                 140                 145                 150

 tgt ctc atc ttg ata gtc att ttc atg atc aca aaa ttt gtc cag gat      652
 Cys Leu Ile Leu Ile Val Ile Phe Met Ile Thr Lys Phe Val Gln Asp
             155                 160                 165

 aga cat aga gct aga aga aac aga ctt cgt aaa gat caa ctt aag aaa      700
 Arg His Arg Ala Arg Arg Asn Arg Leu Arg Lys Asp Gln Leu Lys Lys
         170                 175                 180

 ctt cct gta cat aaa ttc aag aaa gga gat gag tat gat gta tgt gcc      748
 Leu Pro Val His Lys Phe Lys Lys Gly Asp Glu Tyr Asp Val Cys Ala
     185                 190                 195

 att tgt ttg gat gag tat gaa gat gga gac aaa ctc aga atc ctt ccc      796
 Ile Cys Leu Asp Glu Tyr Glu Asp Gly Asp Lys Leu Arg Ile Leu Pro
 200                 205                 210                 215

 tgt tcc cat gct tat cat tgc aag tgt gta gac cct tgg cta act aaa      844
 Cys Ser His Ala Tyr His Cys Lys Cys Val Asp Pro Trp Leu Thr Lys
                 220                 225                 230

 acc aaa aaa acc tgt cca gtg tgc aag caa aaa gtt gtt cct tct caa      892
 Thr Lys Lys Thr Cys Pro Val Cys Lys Gln Lys Val Val Pro Ser Gln
             235                 240                 245

 ggc gat tca gac tct gac aca gac agt agt caa gaa gaa aat gaa gtg      940
 Gly Asp Ser Asp Ser Asp Thr Asp Ser Ser Gln Glu Glu Asn Glu Val
         250                 255                 260

 aca gaa cat acc cct tta ctg aga cct tta gct tct gtc agt gcc cag      988
 Thr Glu His Thr Pro Leu Leu Arg Pro Leu Ala Ser Val Ser Ala Gln
     265                 270                 275

 tca ttt ggg gct tta tcg gaa tcc cgc tca cat cag aac atg aca gaa     1036
 Ser Phe Gly Ala Leu Ser Glu Ser Arg Ser His Gln Asn Met Thr Glu
 280                 285                 290                 295

 tct tca gac tat gag gaa gac gac aat gaa gat act gac agt agt gat     1084
 Ser Ser Asp Tyr Glu Glu Asp Asp Asn Glu Asp Thr Asp Ser Ser Asp
                 300                 305                 310

 gca gaa aat gaa att aat gaa cat gat gtc gtg gtc cag ttg cag cct     1132
 Ala Glu Asn Glu Ile Asn Glu His Asp Val Val Val Gln Leu Gln Pro
             315                 320                 325

 aat ggt gaa cgg gat tac aac ata gca aat act gtt tga ctttcagaag      1181
 Asn Gly Glu Arg Asp Tyr Asn Ile Ala Asn Thr Val 
         330                 335

 atgattggtt tatttccctt taaaatgatt aggtatatac tgtaatttga ttttttgctc   1241

 ccttcaaaga tttctgtaga aataacttat tttttagtat tctacagttt aatcaaatta   1301

 ctgaaacagg acttttgatc tggtatttat ctgccaagaa tatacttcat tcactaataa   1361

 tagactggtg ctgtaactca agcatcaatt cagctcttct tttggaatga aagtatagcc   1421

 aaaacataaa aaaaaaaaaa tcctcagtat agcttgcaat taagacctag atcacagtat   1481

 ttaagtgttt tgcgttttat acatgaggtc agtgctacag ccacctagca tgaactaacc   1541

 cagcttccac ctccataaag ttacctagag ttgttgagtt ggaatatgtt ctggcattta   1601

 cctgacctgc caatcattag ggagaggcaa caaggtaatt cagcctttcc tcctatcagc   1661

 acaaagaaac tcaaagctgt tttttccctt tctgttccaa agcagtctta tcctgacagg   1721

 agcggtctat actagtgcag atttcaacac ttttttttaa cgttttaatt actatagtgt   1781

 tatgtagaga tttgattgag cagctaatgt ttctgaactt tacttactaa ttttcagtgt   1841

 ccttaagggt tctgtagtgt tatcaaagca aaaagaaaat gctgcataaa aataccaaac   1901

 ttcagcaact gttaatactc agatcatata cctcttaata aatagcatct tatgctaatt   1961

 agccctgcta aactatgtac agaggaaact gttcaagtat tggatttgaa agtaagtgac   2021

 ttatgtttaa cagaactaat gatgtattga aacactgtat tatgaaaagc taaattatac   2081

 atcattgtaa ctatgtagaa agtgtagact aatgtataat caaaatgcta aggattttta   2141

 tatggccttg tatgagggga gtttgaatgt taataaacat gttttccact ttaagatcca   2201

 gtaaatgtct gttctactgt agtattactt aaaaaaaaaa a                       2242




      <210> 3
      <211> 2281
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1210)

      <400> 3
 cggcacgagc gtccctgcta gtactccggg ctgtgggggt cggtgcggat attcagtcat     60

 gaaatcaggg tagggacttc tcccgcagcg acgcggctgg caagactgtt tgtgttgcgg    120

 gggccggact tcaaggtgat tttacaacga g   atg ctg ctc tcc ata ggg atg     172
                                      Met Leu Leu Ser Ile Gly Met
                                        1               5

 ctc atg ctg tca gcc aca caa gtc tac acc atc ttg act gtc cag ctc      220
 Leu Met Leu Ser Ala Thr Gln Val Tyr Thr Ile Leu Thr Val Gln Leu
          10                  15                  20

 ttt gca ttc tta aac cta ctg cct gta gaa gca gac att tta gca tat      268
 Phe Ala Phe Leu Asn Leu Leu Pro Val Glu Ala Asp Ile Leu Ala Tyr
      25                  30                  35

 aac ttt gaa aat gca tct cag aca ttt gat gac ctc cct gca aga ttt      316
 Asn Phe Glu Asn Ala Ser Gln Thr Phe Asp Asp Leu Pro Ala Arg Phe
  40                  45                  50                  55

 ggt tat aga ctt cca gct gaa ggt tta aag ggt ttt ttg att aac tca      364
 Gly Tyr Arg Leu Pro Ala Glu Gly Leu Lys Gly Phe Leu Ile Asn Ser
                  60                  65                  70

 aaa cca gag aat gcc tgt gaa ccc ata gtg cct cca cca gta aaa gac      412
 Lys Pro Glu Asn Ala Cys Glu Pro Ile Val Pro Pro Pro Val Lys Asp
              75                  80                  85

 aat tca tct ggc act ttc atc gtg tta att aga aga ctt gat tgt aat      460
 Asn Ser Ser Gly Thr Phe Ile Val Leu Ile Arg Arg Leu Asp Cys Asn
          90                  95                 100

 ttt gat ata aag gtt tta aat gca cag aga gca gga tac aag gca gcc      508
 Phe Asp Ile Lys Val Leu Asn Ala Gln Arg Ala Gly Tyr Lys Ala Ala
     105                 110                 115

 ata gtt cac aat gtt gat tct gat gac ctc att agc atg gga tcc aac      556
 Ile Val His Asn Val Asp Ser Asp Asp Leu Ile Ser Met Gly Ser Asn
 120                 125                 130                 135

 gac att gag gta cta aag aaa att gac att cca tct gtc ttt att ggt      604
 Asp Ile Glu Val Leu Lys Lys Ile Asp Ile Pro Ser Val Phe Ile Gly
                 140                 145                 150

 gaa tca tca gct aat tct ctg aaa gat gaa ttc aca tat gaa aaa ggg      652
 Glu Ser Ser Ala Asn Ser Leu Lys Asp Glu Phe Thr Tyr Glu Lys Gly
             155                 160                 165

 ggc cac ctt atc tta gtt cca gaa ttt agt ctt cct ttg gaa tac tac      700
 Gly His Leu Ile Leu Val Pro Glu Phe Ser Leu Pro Leu Glu Tyr Tyr
         170                 175                 180

 cta att ccc ttc ctt atc ata gtg ggc atc tgt ctc atc ttg ata gtc      748
 Leu Ile Pro Phe Leu Ile Ile Val Gly Ile Cys Leu Ile Leu Ile Val
     185                 190                 195

 att ttc atg atc aca aaa ttt gtc cag gat aga cat aga gct aga aga      796
 Ile Phe Met Ile Thr Lys Phe Val Gln Asp Arg His Arg Ala Arg Arg
 200                 205                 210                 215

 aac aga ctt cgt aaa gat caa ctt aag aaa ctt cct gta cat aaa ttc      844
 Asn Arg Leu Arg Lys Asp Gln Leu Lys Lys Leu Pro Val His Lys Phe
                 220                 225                 230

 aag aaa gga gat gag tat gat gta tgt gcc att tgt ttg gat gag tat      892
 Lys Lys Gly Asp Glu Tyr Asp Val Cys Ala Ile Cys Leu Asp Glu Tyr
             235                 240                 245

 gaa gat gga gac aaa ctc aga atc ctt ccc tgt tcc cat ggc gat tca      940
 Glu Asp Gly Asp Lys Leu Arg Ile Leu Pro Cys Ser His Gly Asp Ser
         250                 255                 260

 gac tct gac aca gac agt agt caa gaa gaa aat gaa gtg aca gaa cat      988
 Asp Ser Asp Thr Asp Ser Ser Gln Glu Glu Asn Glu Val Thr Glu His
     265                 270                 275

 acc cct tta ctg aga cct tta gct tct gtc agt gcc cag tca ttt ggg     1036
 Thr Pro Leu Leu Arg Pro Leu Ala Ser Val Ser Ala Gln Ser Phe Gly
 280                 285                 290                 295

 gct tta tcg gaa tcc cgc tca cat cag aac atg aca gaa tct tca gac     1084
 Ala Leu Ser Glu Ser Arg Ser His Gln Asn Met Thr Glu Ser Ser Asp
                 300                 305                 310

 tat gag gaa gac gac aat gaa gat act gac agt agt gat gca gaa aat     1132
 Tyr Glu Glu Asp Asp Asn Glu Asp Thr Asp Ser Ser Asp Ala Glu Asn
             315                 320                 325

 gaa att aat gaa cat gat gtc gtg gtc cag ttg cag cct aat ggt gaa     1180
 Glu Ile Asn Glu His Asp Val Val Val Gln Leu Gln Pro Asn Gly Glu
         330                 335                 340

 cgg gat tac aac ata gca aat act gtt tga c tttcagaaga tgattggttt     1231
 Arg Asp Tyr Asn Ile Ala Asn Thr Val 
     345                 350

 atttcccttt aaaatgatta ggtatatact gtaatttgat tttttgctcc cttcaaagat   1291

 ttctgtagaa ataacttatt ttttagtatt ctacagttta atcaaattac tgaaacagga   1351

 cttttgatct ggtatttatc tgccaagaat atacttcatt cactaataat agactggtgc   1411

 tgtaactcaa gcatcaattc agctcttctt ttggaatgaa agtatagcca aaacataaaa   1471

 aaaaaaaaat cctcagtata gcttgcaatt aagacctaga tcacagtatt taagtgtttt   1531

 gcgttttata catgaggtca gtgctacagc cacctagcat gaactaaccc agcttccacc   1591

 tccataaagt tacctagagt tgttgagttg gaatatgttc tggcatttac ctgacctgcc   1651

 aatcattagg gagaggcaac aaggtaattc agcctttcct cctatcagca caaagaaact   1711

 caaagctgtt ttttcccttt ctgttccaaa gcagtcttat cctgacagga gcggtctata   1771

 ctagtgcaga tttcaacact tttttttaac gttttaatta ctatagtgtt atgtagagat   1831

 ttgattgagc agctaatgtt tctgaacttt acttactaat tttcagtgtc cttaagggtt   1891

 ctgtagtgtt atcaaagcaa aaagaaaatg ctgcataaaa ataccaaact tcagcaactg   1951

 ttaatactca gatcatatac ctcttaataa atagcatctt atgctaatta gccctgctaa   2011

 actatgtaca gaggaaactg ttcaagtatt ggatttgaaa gtaagtgact tatgtttaac   2071

 agaactaatg atgtattgaa acactgtatt atgaaaagct aaattataca tcattgtaac   2131

 tatgtagaaa gtgtagacta atgtataatc aaaatgctaa ggatttttat atggccttgt   2191

 atgaggggag tttgaatgtt aataaacatg ttttccactt taagatccag taaatgtctg   2251

 ttctactgta gtattactta aaaaaaaaaa                                    2281




      <210> 4
      <211> 2248
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(842)

      <400> 4
 agccacgcgg cgccagcgag gcggccggac ccgcagcccc g    atg ctg ctg acg      53
                                                  Met Leu Leu Thr
                                                    1

 ctg gcc ggg ggc gcg ctc ttc ttc ccg ggg ctc ttc gcg ctc tgc acc      101
 Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe Ala Leu Cys Thr
   5                  10                  15                  20

 tgg gcg ctg cgc cgc tcc cag ccc gga tgg agc cgc acc gac tgc gtg      149
 Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg Thr Asp Cys Val
                  25                  30                  35

 atg atc agc acc agg ctg gtt tcc tcg gtg cac gcc gtg ctg gcc acc      197
 Met Ile Ser Thr Arg Leu Val Ser Ser Val His Ala Val Leu Ala Thr
              40                  45                  50

 ggc tcg ggg atc gtc atc att cgc tcc tgc gac gac gtg atc acc ggc      245
 Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp Val Ile Thr Gly
          55                  60                  65

 agg cac tgg ctt gcc cgg gaa tat gtg tgg ttt ctg att cca tac atg      293
 Arg His Trp Leu Ala Arg Glu Tyr Val Trp Phe Leu Ile Pro Tyr Met
      70                  75                  80

 atc tat gac tcg tac gcc atg tac ctc tgt gaa tgg tgc cga acc aga      341
 Ile Tyr Asp Ser Tyr Ala Met Tyr Leu Cys Glu Trp Cys Arg Thr Arg
  85                  90                  95                 100

 gac cag aac cgt gcg ccc tcc ctc act ctt cga aac ttc cta agt cga      389
 Asp Gln Asn Arg Ala Pro Ser Leu Thr Leu Arg Asn Phe Leu Ser Arg
                 105                 110                 115

 aac cgc ctc atg atc aca cat cat gcg gtc att ctc ttt gtc ctt gtg      437
 Asn Arg Leu Met Ile Thr His His Ala Val Ile Leu Phe Val Leu Val
             120                 125                 130

 cca gtc gca cag agg ctc cgg gga gac ctt ggg gac ttc ttt gtc ggc      485
 Pro Val Ala Gln Arg Leu Arg Gly Asp Leu Gly Asp Phe Phe Val Gly
         135                 140                 145

 tgc atc ttc acg gca gaa ctg agc act ccg ttt gtg tcg ctg ggc agg      533
 Cys Ile Phe Thr Ala Glu Leu Ser Thr Pro Phe Val Ser Leu Gly Arg
     150                 155                 160

 gtt ctg att cag gca tgt atg aat gaa atg aca gag agt cta aag cag      581
 Val Leu Ile Gln Ala Cys Met Asn Glu Met Thr Glu Ser Leu Lys Gln
 165                 170                 175                 180

 cag cac acc ctt ctg tac aag gtg aat gga atc ctc acg ctg gcc acc      629
 Gln His Thr Leu Leu Tyr Lys Val Asn Gly Ile Leu Thr Leu Ala Thr
                 185                 190                 195

 ttc ctt tcc tgc cgg atc ctt ctc ttc ccc ttc atg tac tgg tcc tat      677
 Phe Leu Ser Cys Arg Ile Leu Leu Phe Pro Phe Met Tyr Trp Ser Tyr
             200                 205                 210

 ggc cgc cag cag gga cta agc ctg ctc caa gta ccc ttc agc atc cca      725
 Gly Arg Gln Gln Gly Leu Ser Leu Leu Gln Val Pro Phe Ser Ile Pro
         215                 220                 225

 ttc tac tgc aac gtg gcc aat gcc ttc ctc gta gct cct cag atc tac      773
 Phe Tyr Cys Asn Val Ala Asn Ala Phe Leu Val Ala Pro Gln Ile Tyr
     230                 235                 240

 tgg ttc tgt ctg ctg tgc agg aag gca gtc cgg ctc ttt gac act ccc      821
 Trp Phe Cys Leu Leu Cys Arg Lys Ala Val Arg Leu Phe Asp Thr Pro
 245                 250                 255                 260

 caa gcc aaa aag gat ggc taa at gctcctggga gtcaggcgca gcctcacacc      874
 Gln Ala Lys Lys Asp Gly 
                 265

 agctgcctcc tccactcagc attccatgga ccaaattgtg ccctgggtag cctcagactt    934

 tgggtattga taagccgatg gatttgagtt tttctaaaga atattcatat tacctccttc    994

 ttctaacttg ccctatttgc aaacgcactt ttgtagtaac aactattggg tcctgtcaga   1054

 cctccacgga cagcaaagtg gttttaatgc aagcccaagg atccttctta aggtcttatc   1114

 tcaagagctc tgggaggtgg aagcatgggg tgggatcggt ggaccagggt ggtaagtgtc   1174

 tgcacatctg cctgtccctg tatcagcggc tacccacctt ccaaaccact caggacagta   1234

 cccgtggcac tgggcccgca gaagcaaggg atgacttggt tcttggaagt aatgtcgtct   1294

 tgtgacattg gcctgggaca atcattgtgg gtaggtagtt attgatcgtt tactagataa   1354

 cccattggtt ctttgcctca tcctctcatc catgggtcag agttgaattc ttatgtctat   1414

 agacttccaa tcagaagtct cactggtggg gctgggggtg ggggcaggca ggaggcatgg   1474

 atgggaacct gagtaggtag tgtggccaag agatcagcac aacctttgca ggctgacttg   1534

 ctaagtctga cagtgacaaa cttgtgagct tactgcagtc agtcacagag gctgttcttt   1594

 ttcacacacc ccttcatgcc cggctttccc catatccaca tgcagagggc gagctcataa   1654

 aactacaggg aagcgtgaaa tgatggcttt ggtagctgtt tactgggtaa ccccactgtg   1714

 acactgtcct tttcatgtga tgtggaaacc tacttctgtc ctccaaacca tgaaatgtgt   1774

 catctagact gcagagtact tgagtgcttt gcctcccgat atgccagagc ttgtggtcca   1834

 aagcccattc ctgtgtgtcc gtcctgccat ttagccacag aaggctgcgg agtgaggcgg   1894

 cagctagcct ggccagtggc tgtcccgtgg accgacacct gcgccccctt ctgcaagcag   1954

 gattttctgg tgccaacact cattcatcat tcccgatcaa ctaggatgaa tttaagactg   2014

 tgctaccatg tgttctcaag tggtagttta aaaagtggat ttttaaagtg cctttcaatt   2074

 gtctgtgaac gtctaaagga ctgatttgtc tcattttgac tgttgagtct ttaatgggtg   2134

 ccatttaaaa aacaaaatgc tattttttaa ttgtcttttt tttttaacta tcagtgtatc   2194

 tttaaaagtc acccttacgg tgattaaatt gcactaacat tcccaaaaaa aaaa         2248




      <210> 5
      <211> 491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(397)

      <400> 5
 acggaaggag cggcggcgac tgaggaggag g   atg gag gcg gtg gtg ttc gtc      52
                                      Met Glu Ala Val Val Phe Val
                                        1               5

 ttc tct ctc ctc gat tgt tgc gcg ctc atc ttc ctc tcg gtc tac ttc      100
 Phe Ser Leu Leu Asp Cys Cys Ala Leu Ile Phe Leu Ser Val Tyr Phe
          10                  15                  20

 ata att aca ttg tct gat tta gaa tgt gat tac att aat gct aga tca      148
 Ile Ile Thr Leu Ser Asp Leu Glu Cys Asp Tyr Ile Asn Ala Arg Ser
      25                  30                  35

 tgt tgc tca tta ctg ctc atg tca ttg cac tgg ttc atc ttc ctt ctc      196
 Cys Cys Ser Leu Leu Leu Met Ser Leu His Trp Phe Ile Phe Leu Leu
  40                  45                  50                  55

 aac tta cct gtt gcc act tgg aat ata tat cga tac att atg gtg ccg      244
 Asn Leu Pro Val Ala Thr Trp Asn Ile Tyr Arg Tyr Ile Met Val Pro
                  60                  65                  70

 agt ggt aac atg gga gtg ttt gat cca aca gaa ata cac aat cga ggg      292
 Ser Gly Asn Met Gly Val Phe Asp Pro Thr Glu Ile His Asn Arg Gly
              75                  80                  85

 cag ctg aag tca cac atg aaa gaa gcc atg atc aag ctt ggt ttc cac      340
 Gln Leu Lys Ser His Met Lys Glu Ala Met Ile Lys Leu Gly Phe His
          90                  95                 100

 ttg ctc tgc ttc ttc atg tat ctt tat agt atg atc tta gct ttg ata      388
 Leu Leu Cys Phe Phe Met Tyr Leu Tyr Ser Met Ile Leu Ala Leu Ile
     105                 110                 115

 aat gac tga agctgga gaagccgtgt tgaagtcagc ctacactaca gtgcacagtt      444
 Asn Asp 
 120

 gaggagccag agacttctta atcattctta gaccgtgacc atagcag                  491




      <210> 6
      <211> 767
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(713)

      <400> 6
 caggggccct gagtaacggt ggcctggggt cagagccagg ttcagctgcg aggctgctgg     60

 tggctgtgga gagcttgggg cttccttggt cgcacccacc acctgcctgc ccactggtca    120

 gccttcaggg accctgagca ccgcctggtc tctttcctgt ggccagccca gaactgaagc    180

 gctgcggc atg gcg cgc gcc tgc ctc cag gcc gtc aag tac ctc atg ttc     230
          Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe
            1               5                  10

 gcc ttc aac ctg ctc ttc tgg ttc ttc ctg ctg ctg ctg ctg gtg ttc      278
 Ala Phe Asn Leu Leu Phe Trp Phe Phe Leu Leu Leu Leu Leu Val Phe
  15                  20                  25                  30

 ctg ctg gag gcc acc atc gcc atc ctc ttc ttc gcc tac acg gac aag      326
 Leu Leu Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys
                  35                  40                  45

 att gac agg tat gcc cag caa gac ctg aag aaa ggc ttg cac ctg tac      374
 Ile Asp Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr
              50                  55                  60

 ggc acg cag ggc aac gtg ggc ctc acc aac gcc tgg agc atc atc cag      422
 Gly Thr Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln
          65                  70                  75

 acc gac ttc cgc tgc tgt ggc gtc tcc aac tac act gac tgg ttc gag      470
 Thr Asp Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu
      80                  85                  90

 gtg tac aac gcc acg cgg gta cct gac tcc tgc tgc ttg gag ttc agt      518
 Val Tyr Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser
  95                 100                 105                 110

 gag agc tgt ggg ctg cac gcc ccc ggc acc tgg tgg aag gcg ccg tgc      566
 Glu Ser Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys
                 115                 120                 125

 tac gag acg gtg aag gtg tgg ctt cag gag aac ctg ctg gct gtg ggc      614
 Tyr Glu Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly
             130                 135                 140

 atc ttt ggg ctg tgc acg gcg ctg gtg cag atc ctg ggc ctg acc ttc      662
 Ile Phe Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe
         145                 150                 155

 gcc atg acc atg tac tgc caa gtg gtc aag gca gac acc tac tgc gcg      710
 Ala Met Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala
     160                 165                 170

 tag gccg cccaccgccc gcttctctgc caaaaggacg cccacgggga gatggccgca      767
 






      <210> 7
      <211> 1545
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(1502)

      <400> 7
 agcatgccgg gagccgccgg ccgccggtgt ccggaccgct cgcccccgtt tggacccgac     60

 ttcggttctt ctggggtgtt gatgctccta aagcccgaga gcacgtgtcc agaccctagc    120

 ctgtacgacg ctgactctgc ccggtcccag aaccaaagcc atgccggggt gtggcctctg    180

 accccacgcg gaggggacct cgccttgcgg gaccccacct ggaacccgac ctcccagcct    240

 cgcagccggc ctgagccgcc    atg cgc ggg aag ttg ctg ccg ctg gcc ggc     290
                          Met Arg Gly Lys Leu Leu Pro Leu Ala Gly
                            1               5                  10

 ctc tac ctg gtg cag ggc ctg ccc tac ggg ctc cag tcc ggc ctc ctg      338
 Leu Tyr Leu Val Gln Gly Leu Pro Tyr Gly Leu Gln Ser Gly Leu Leu
                  15                  20                  25

 cca gtg ctg ctg cgt gcc ggc ggc ctc tcg ctg acg cgc gtg ggg ctg      386
 Pro Val Leu Leu Arg Ala Gly Gly Leu Ser Leu Thr Arg Val Gly Leu
              30                  35                  40

 gcc aag gtt ctg tac gct ccg tgg ctg ctc aag ctg gct tgg gcc ccg      434
 Ala Lys Val Leu Tyr Ala Pro Trp Leu Leu Lys Leu Ala Trp Ala Pro
          45                  50                  55

 ctg gtg gac gcg cag ggc tcg gcg agg gcc tgg gtg acg cgc agc acg      482
 Leu Val Asp Ala Gln Gly Ser Ala Arg Ala Trp Val Thr Arg Ser Thr
      60                  65                  70

 gcg ggc ctg ggc ctg gtg tgt ggg ctg ctt gcc ggg ctg ccc cct cct      530
 Ala Gly Leu Gly Leu Val Cys Gly Leu Leu Ala Gly Leu Pro Pro Pro
  75                  80                  85                  90

 gga gct ggc cag gcc ggg ctg ccc gcc gct gtg gcg ggg ttg ctg ctg      578
 Gly Ala Gly Gln Ala Gly Leu Pro Ala Ala Val Ala Gly Leu Leu Leu
                  95                 100                 105

 ttg ttg aac ctg ggt gcc gcc atg cac gga tgt ggc cct gga cgc gcc      626
 Leu Leu Asn Leu Gly Ala Ala Met His Gly Cys Gly Pro Gly Arg Ala
             110                 115                 120

 tgg cct gtg cag ctg ctg gag ccg gcc gaa ctg ggg ccg ggc aat acc      674
 Trp Pro Val Gln Leu Leu Glu Pro Ala Glu Leu Gly Pro Gly Asn Thr
         125                 130                 135

 gtg cag gtg gtc gcg tac aag ctg ggg gcc gcg cta gct ggg ggc gcg      722
 Val Gln Val Val Ala Tyr Lys Leu Gly Ala Ala Leu Ala Gly Gly Ala
     140                 145                 150

 ctg ctg gcg ctg ctg ccc acc ttc tcg tgg ccg caa ctc ttt ctg ctc      770
 Leu Leu Ala Leu Leu Pro Thr Phe Ser Trp Pro Gln Leu Phe Leu Leu
 155                 160                 165                 170

 ctg gct gcc acc tac tgg ctg gcc gcg gcc ctg gcc tgg gct gca cca      818
 Leu Ala Ala Thr Tyr Trp Leu Ala Ala Ala Leu Ala Trp Ala Ala Pro
                 175                 180                 185

 gcc ctg cgg cgg ctc cca cag cag ccc cct tcc gag cag cgt ccc cac      866
 Ala Leu Arg Arg Leu Pro Gln Gln Pro Pro Ser Glu Gln Arg Pro His
             190                 195                 200

 acc gcg cac ctt ctg cgg gac gtg cta gcc gtg ccg ggg acc gtg tgg      914
 Thr Ala His Leu Leu Arg Asp Val Leu Ala Val Pro Gly Thr Val Trp
         205                 210                 215

 acg gca ggc ttt gtg ctc acc tac aag ctg ggt gag cag ggt gcc agc      962
 Thr Ala Gly Phe Val Leu Thr Tyr Lys Leu Gly Glu Gln Gly Ala Ser
     220                 225                 230

 agc ctg ttt cct ctt ctc ctg ctg gac cac ggc gtt tct gct ccc gag     1010
 Ser Leu Phe Pro Leu Leu Leu Leu Asp His Gly Val Ser Ala Pro Glu
 235                 240                 245                 250

 ttg gga ctg tgg aat ggt gtg ggt gct gtg gtc tgc tcc atc gct ggc     1058
 Leu Gly Leu Trp Asn Gly Val Gly Ala Val Val Cys Ser Ile Ala Gly
                 255                 260                 265

 tcc tcc ctg ggt ggg acc ttg ctg gcc aag cac tgg aaa ctg ctg cct     1106
 Ser Ser Leu Gly Gly Thr Leu Leu Ala Lys His Trp Lys Leu Leu Pro
             270                 275                 280

 ctg ttg agg tcg gtg ctg cgc ttc cgc ctc ggg ggc cta gcc tgt cag     1154
 Leu Leu Arg Ser Val Leu Arg Phe Arg Leu Gly Gly Leu Ala Cys Gln
         285                 290                 295

 act gcc ttg gtc ttc cac ctg gac acc ctg ggg gcc agc atg gac gct     1202
 Thr Ala Leu Val Phe His Leu Asp Thr Leu Gly Ala Ser Met Asp Ala
     300                 305                 310

 ggc aca atc ttg aga ggg tca gcc ttg ctg agc cta tgt ctg cag cac     1250
 Gly Thr Ile Leu Arg Gly Ser Ala Leu Leu Ser Leu Cys Leu Gln His
 315                 320                 325                 330

 ttc ttg gga ggc ctg gtc acc aca gtc acc ttc act ggg atg atg cgc     1298
 Phe Leu Gly Gly Leu Val Thr Thr Val Thr Phe Thr Gly Met Met Arg
                 335                 340                 345

 tgc agc cag ctg gcc ccc agg gcc ctg cag gcc aca cac tac agc ctt     1346
 Cys Ser Gln Leu Ala Pro Arg Ala Leu Gln Ala Thr His Tyr Ser Leu
             350                 355                 360

 ctg gcc acg ctg gag ctg ctg ggg aag ctg ctg ctg ggc act ctg gcc     1394
 Leu Ala Thr Leu Glu Leu Leu Gly Lys Leu Leu Leu Gly Thr Leu Ala
         365                 370                 375

 gga ggc ctg gct gat ggg ttg ggg cca cat ccc tgc ttc ttg ctc ctg     1442
 Gly Gly Leu Ala Asp Gly Leu Gly Pro His Pro Cys Phe Leu Leu Leu
     380                 385                 390

 ctc atc ctc tct gcc ttt ccc gtt ctg tac ctg gac cta gca ccc agc     1490
 Leu Ile Leu Ser Ala Phe Pro Val Leu Tyr Leu Asp Leu Ala Pro Ser
 395                 400                 405                 410

 acc ttt ctc tga gct gagtggctgg agtggtcaat aaagccacat gtgcctgtga     1545
 Thr Phe Leu 






      <210> 8
      <211> 2899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (260)..(1804)

      <400> 8
 ggactttgcg gcgggagcgc ggcgcggtga agcaccggcg cggagggcgc ccggcgtagg     60

 cggcggcggg tgtgggccga gccggtattt atagctccgt gacagcagca gcggcagcga    120

 cgccgccggc ccgtctcgcc gcgcttccca gcgaggccgc cggcgcgccg agggctgtgc    180

 tcgaccgcga atcccgtgtg cagtcgcccc gcgccccgcg cgacccttcg ggtaaactac    240

 gaactgggag ttctgaaga atg ggt aaa gac ttt cgt tac tat ttc cag cat     292
                      Met Gly Lys Asp Phe Arg Tyr Tyr Phe Gln His
                        1               5                  10

 ccc tgg tct cgc atg att gtg gct tac ttg gtg atc ttc ttt aac ttc      340
 Pro Trp Ser Arg Met Ile Val Ala Tyr Leu Val Ile Phe Phe Asn Phe
              15                  20                  25

 tta ata ttt gcg gag gac cca gtt tct cat agc caa aca gaa gcc aat      388
 Leu Ile Phe Ala Glu Asp Pro Val Ser His Ser Gln Thr Glu Ala Asn
          30                  35                  40

 gtt att gtt gtt gga aac tgt ttt tca ttt gtt aca aat aaa tac cct      436
 Val Ile Val Val Gly Asn Cys Phe Ser Phe Val Thr Asn Lys Tyr Pro
      45                  50                  55

 aga gga gtt ggc tgg agg att ttg aag gtg ctt cta tgg cta ctt gcc      484
 Arg Gly Val Gly Trp Arg Ile Leu Lys Val Leu Leu Trp Leu Leu Ala
  60                  65                  70                  75

 att ctc aca gga cta ata gct ggc aaa ttt ctg ttc cat cag cgt ttg      532
 Ile Leu Thr Gly Leu Ile Ala Gly Lys Phe Leu Phe His Gln Arg Leu
                  80                  85                  90

 ttt ggt cag ttg ctc cga tta aaa atg ttt cga gaa gat cat ggg tcg      580
 Phe Gly Gln Leu Leu Arg Leu Lys Met Phe Arg Glu Asp His Gly Ser
              95                 100                 105

 tgg atg aca atg ttc ttc agc aca att ctc ttt ctc ttc ata ttt tct      628
 Trp Met Thr Met Phe Phe Ser Thr Ile Leu Phe Leu Phe Ile Phe Ser
         110                 115                 120

 cac ata tac aac acg att ctt cta atg gat ggg aac atg gga gca tat      676
 His Ile Tyr Asn Thr Ile Leu Leu Met Asp Gly Asn Met Gly Ala Tyr
     125                 130                 135

 atc att aca gac tat atg ggc atc cga aat gaa agt ttc atg aaa tta      724
 Ile Ile Thr Asp Tyr Met Gly Ile Arg Asn Glu Ser Phe Met Lys Leu
 140                 145                 150                 155

 gct gca gta ggg acc tgg atg ggg gac ttt gtc aca gct tgg atg gtc      772
 Ala Ala Val Gly Thr Trp Met Gly Asp Phe Val Thr Ala Trp Met Val
                 160                 165                 170

 act gat atg atg ctt cag gac aaa ccc tat cct gac tgg gga aaa tca      820
 Thr Asp Met Met Leu Gln Asp Lys Pro Tyr Pro Asp Trp Gly Lys Ser
             175                 180                 185

 gca aga gct ttc tgg aag aaa gga aat gtt agg atc act tta ttc tgg      868
 Ala Arg Ala Phe Trp Lys Lys Gly Asn Val Arg Ile Thr Leu Phe Trp
         190                 195                 200

 aca gtt ctt ttt act ctg acg tct gtg gtt gta ctt gtg att aca acg      916
 Thr Val Leu Phe Thr Leu Thr Ser Val Val Val Leu Val Ile Thr Thr
     205                 210                 215

 gac tgg atc agc tgg gac aag ctg aat cgg gga ttt ttg ccc agt gat      964
 Asp Trp Ile Ser Trp Asp Lys Leu Asn Arg Gly Phe Leu Pro Ser Asp
 220                 225                 230                 235

 gaa gtt tcc aga gca ttc ctt gct tct ttt atc ttg gtc ttt gac ctt     1012
 Glu Val Ser Arg Ala Phe Leu Ala Ser Phe Ile Leu Val Phe Asp Leu
                 240                 245                 250

 ctt att gtg atg cag gac tgg gaa ttc cca cat ttc atg gga gat gtt     1060
 Leu Ile Val Met Gln Asp Trp Glu Phe Pro His Phe Met Gly Asp Val
             255                 260                 265

 gat gta aat ctc cct ggt ttg cac acc cct cac atg cag ttc aag att     1108
 Asp Val Asn Leu Pro Gly Leu His Thr Pro His Met Gln Phe Lys Ile
         270                 275                 280

 cct ttc ttc cag aaa atc ttc aag gag gaa tat cgt att cac ata aca     1156
 Pro Phe Phe Gln Lys Ile Phe Lys Glu Glu Tyr Arg Ile His Ile Thr
     285                 290                 295

 ggc aaa tgg ttt aac tat gga att atc ttc ctc gtc ttg att ttg gat     1204
 Gly Lys Trp Phe Asn Tyr Gly Ile Ile Phe Leu Val Leu Ile Leu Asp
 300                 305                 310                 315

 ctt aat atg tgg aag aac caa ata ttt tat aaa cct cat gaa tat ggg     1252
 Leu Asn Met Trp Lys Asn Gln Ile Phe Tyr Lys Pro His Glu Tyr Gly
                 320                 325                 330

 caa tat atc ggc ccg ggg cag aag ata tat aca gtg aaa gac tca gaa     1300
 Gln Tyr Ile Gly Pro Gly Gln Lys Ile Tyr Thr Val Lys Asp Ser Glu
             335                 340                 345

 agt tta aaa gat ttg aac aga acc aag cta tcc tgg gaa tgg agg tcc     1348
 Ser Leu Lys Asp Leu Asn Arg Thr Lys Leu Ser Trp Glu Trp Arg Ser
         350                 355                 360

 aat cac act aac cct cgg act aat aaa aca tat gtt gag gga gac atg     1396
 Asn His Thr Asn Pro Arg Thr Asn Lys Thr Tyr Val Glu Gly Asp Met
     365                 370                 375

 ttc tta cac agc agg ttc ata gga gcc agt ctt gat gtc aag tgt ctg     1444
 Phe Leu His Ser Arg Phe Ile Gly Ala Ser Leu Asp Val Lys Cys Leu
 380                 385                 390                 395

 gcc ttt gtt cca agc ctg ata gcc ttt gtg tgg ttt gga ttc ttt att     1492
 Ala Phe Val Pro Ser Leu Ile Ala Phe Val Trp Phe Gly Phe Phe Ile
                 400                 405                 410

 tgg ttc ttt gga cga ttt ttg aaa aat gag cca cgc atg gag aat caa     1540
 Trp Phe Phe Gly Arg Phe Leu Lys Asn Glu Pro Arg Met Glu Asn Gln
             415                 420                 425

 gac aaa act tac act cgc atg aaa aga aaa tct cca tca gaa cat agc     1588
 Asp Lys Thr Tyr Thr Arg Met Lys Arg Lys Ser Pro Ser Glu His Ser
         430                 435                 440

 aaa gac atg gga atc act cga gaa aac acc cag gct tca gta gaa gac     1636
 Lys Asp Met Gly Ile Thr Arg Glu Asn Thr Gln Ala Ser Val Glu Asp
     445                 450                 455

 ccc ttg aat gac cct tct ttg gtt tgc atc agg tct gac ttc aat gag     1684
 Pro Leu Asn Asp Pro Ser Leu Val Cys Ile Arg Ser Asp Phe Asn Glu
 460                 465                 470                 475

 atc gtc tac aag tct tcc cac cta acc tcg gaa aac ttg agc tca cag     1732
 Ile Val Tyr Lys Ser Ser His Leu Thr Ser Glu Asn Leu Ser Ser Gln
                 480                 485                 490

 ttg aac gaa tct act agt gca aca gaa gct gat caa gac cca acg act     1780
 Leu Asn Glu Ser Thr Ser Ala Thr Glu Ala Asp Gln Asp Pro Thr Thr
             495                 500                 505

 tct aaa agt aca cct acg aac tag actcggagat agacttggag ataacacaaa    1834
 Ser Lys Ser Thr Pro Thr Asn 
         510

 aagcaacctt gagtgtaact ttaaaaattt agtctttcct tttgtatatg taaggtttac   1894

 gtagtgttag gtaaaaatat gaacaatgcc acaacggtgc tcaacatgct ttttctagga   1954

 ttcattgttt tctatttgta ttataataca cgtgcctact gtatactcaa cagtcctcta   2014

 gagattgctt ttcacaattg cacaagctat tactgacttt acagcatagt ggaagattag   2074

 ctgatgaccc atgtatctga tgttcaacca tagtggtgcc ttgagacatt aaactgtttt   2134

 taactgtacc agaaatgaag tgtggaacag ttacctaacc tatttcacat gggcgttttg   2194

 tatacaacta ttttgatcta cacttgatgt ctgagcagaa aacagaaata gctaaatgtg   2254

 actcaggaag tatctcttgg tttcttattc agcagcagag ttggtgactt tgacaactgg   2314

 actgcagaga aacatggtga tcacctttta atttttattg gctgtctgcc aaatataaat   2374

 acagatgcaa aattcagtaa taggagatcc ataacccaac atgggtcact actcgtgaaa   2434

 tgtgactttc tcccaccagt aattgaaatg aggtgatgat acctaattat gttttcctaa   2494

 ttaaagataa attgctactt gattaaaaat cctgcccttc acctttggga acaaaggtta   2554

 agagacacag ttgggcgaac tctcaaattt attggcattt acacaaagtc ccagacaacc   2614

 aaggaactga agttttcatc atatgagagc agcacatccc accatttaca atattcgtat   2674

 atctttctgc aaatatggct ctggatagtg aaaattgaaa aacatatgcc aaccctgagc   2734

 aagggaactc ctcaaaaaat catgcagcgg aaccttgtca ggtagagaag ccgtgcatga   2794

 aagaatttgt ttaatgtctt gttttgcgta tgtgtttttt gtttttgttt tttaagaact   2854

 aaatattgca cattaataaa taagaattat acagcaaaaa aaaaa                   2899




      <210> 9
      <211> 3212
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (188)..(3007)

      <400> 9
 gcgctccgga attcccgggc atcattcagc ggcgccacgg agtcacacgt gctgcagatc     60

 ctgcagccag gtggagagtg cctcgttcac cgatggcagt gtcctcgacc cgacccagag    120

 cagattgtcc aactgctggc gcctctatgc ctggatccct ctgctcatat ttcccttctt    180

 actgtac  atg gtc ctg cct ccc agc ttg atg gtg gcc ggc gtg tac tgc     229
          Met Val Leu Pro Pro Ser Leu Met Val Ala Gly Val Tyr Cys
            1               5                  10

 ctc gtg gtg gct gtc atc ttt gct act atc aag act gtc aat tat cgg      277
 Leu Val Val Ala Val Ile Phe Ala Thr Ile Lys Thr Val Asn Tyr Arg
  15                  20                  25                  30

 ctt cat gcc atg ttt gac cag ggc gag atc gtg gag aag cgc agc tct      325
 Leu His Ala Met Phe Asp Gln Gly Glu Ile Val Glu Lys Arg Ser Ser
                  35                  40                  45

 acc atg ggg gag ctg gag gaa gag cct gcc cag ggg gac agc aat cca      373
 Thr Met Gly Glu Leu Glu Glu Glu Pro Ala Gln Gly Asp Ser Asn Pro
              50                  55                  60

 ccc agg gac ccc gga gtg gag atg aca gtg ttc cgg aaa gtc agt tcc      421
 Pro Arg Asp Pro Gly Val Glu Met Thr Val Phe Arg Lys Val Ser Ser
          65                  70                  75

 aca ccc ccg gtg cgc tgc agc tcc cag cac tct gtg ttt ggc ttc aac      469
 Thr Pro Pro Val Arg Cys Ser Ser Gln His Ser Val Phe Gly Phe Asn
      80                  85                  90

 cag gtc tcg gag ctg ctg ccc cga atg gag gac tct ggg ccc ctt aga      517
 Gln Val Ser Glu Leu Leu Pro Arg Met Glu Asp Ser Gly Pro Leu Arg
  95                 100                 105                 110

 gac atc aag gag ctg gtg cgg gag cag ggc agc aac aat gtg atc gtg      565
 Asp Ile Lys Glu Leu Val Arg Glu Gln Gly Ser Asn Asn Val Ile Val
                 115                 120                 125

 act tct gcc gac cga gag atg ctg aag ctc agc tcg cag gag aaa ctg      613
 Thr Ser Ala Asp Arg Glu Met Leu Lys Leu Ser Ser Gln Glu Lys Leu
             130                 135                 140

 att gga gac ctt ccc cag acg cct cca ggg gct gtc cca gac ccc tct      661
 Ile Gly Asp Leu Pro Gln Thr Pro Pro Gly Ala Val Pro Asp Pro Ser
         145                 150                 155

 ctt gcc agt aca gac tct tca gag cct tct ccc ctg gct gga gat gga      709
 Leu Ala Ser Thr Asp Ser Ser Glu Pro Ser Pro Leu Ala Gly Asp Gly
     160                 165                 170

 gcg ccc tgg agt ggg agc agc atg gct gac act ccc atg agc ccc ctg      757
 Ala Pro Trp Ser Gly Ser Ser Met Ala Asp Thr Pro Met Ser Pro Leu
 175                 180                 185                 190

 ctg aag ggg agc ctc agc cag gag ctg agc aag agc ttc ctg acc ctg      805
 Leu Lys Gly Ser Leu Ser Gln Glu Leu Ser Lys Ser Phe Leu Thr Leu
                 195                 200                 205

 acc cag cct gac cgg gcc ctg gtg agg acc agc agt cga cgg gaa caa      853
 Thr Gln Pro Asp Arg Ala Leu Val Arg Thr Ser Ser Arg Arg Glu Gln
             210                 215                 220

 cgc agg ggg gca ggt ggc tat cag ccc ctt gac cgg cgg ggc tca ggg      901
 Arg Arg Gly Ala Gly Gly Tyr Gln Pro Leu Asp Arg Arg Gly Ser Gly
         225                 230                 235

 gag ccc acg ccc cag aaa gcc ggc tcc tca gac tcc tgc ttc agc ggc      949
 Glu Pro Thr Pro Gln Lys Ala Gly Ser Ser Asp Ser Cys Phe Ser Gly
     240                 245                 250

 act gac agg gag aca ttg agc agc ttc aag agt gag aag acc aac tcc      997
 Thr Asp Arg Glu Thr Leu Ser Ser Phe Lys Ser Glu Lys Thr Asn Ser
 255                 260                 265                 270

 acc cat ctg gac agc ccc cca ggg ggg cca gcc cct gag ggc agc gac     1045
 Thr His Leu Asp Ser Pro Pro Gly Gly Pro Ala Pro Glu Gly Ser Asp
                 275                 280                 285

 aca gac cca ccc tct gag gct gag ctg cct gcc tca cca gac gcc ggg     1093
 Thr Asp Pro Pro Ser Glu Ala Glu Leu Pro Ala Ser Pro Asp Ala Gly
             290                 295                 300

 gtc ccc tca gat gac acg ctg cgt tcc ttt gac acg gtc att gga gca     1141
 Val Pro Ser Asp Asp Thr Leu Arg Ser Phe Asp Thr Val Ile Gly Ala
         305                 310                 315

 ggg acg cca ccg ggc ctg gct gag ccg ctc ctg gtc gtg cgg ccc aag     1189
 Gly Thr Pro Pro Gly Leu Ala Glu Pro Leu Leu Val Val Arg Pro Lys
     320                 325                 330

 gac ttg gcc ctg cta cgg cct agc aaa cgg cag cca ccc ctg cga aga     1237
 Asp Leu Ala Leu Leu Arg Pro Ser Lys Arg Gln Pro Pro Leu Arg Arg
 335                 340                 345                 350

 cac tct cca cct ggc cgt gcc cct cga cgg ccc ctg ctt gaa ggt ggg     1285
 His Ser Pro Pro Gly Arg Ala Pro Arg Arg Pro Leu Leu Glu Gly Gly
                 355                 360                 365

 ggc ttc ttt gag gat gaa gac act agt gag ggc agt gaa ctg agc ccg     1333
 Gly Phe Phe Glu Asp Glu Asp Thr Ser Glu Gly Ser Glu Leu Ser Pro
             370                 375                 380

 gcc tcc agt ctc cga tcg cag cgc cgc tac agt act gac agc tcc tct     1381
 Ala Ser Ser Leu Arg Ser Gln Arg Arg Tyr Ser Thr Asp Ser Ser Ser
         385                 390                 395

 tct act tcc tgc tac tcc cct gag agc tcc cgg ggt gca gca ggg gga     1429
 Ser Thr Ser Cys Tyr Ser Pro Glu Ser Ser Arg Gly Ala Ala Gly Gly
     400                 405                 410

 ccc cgg aag cgg agg gcc ccc cat ggg gct gag gag gga act gct gtg     1477
 Pro Arg Lys Arg Arg Ala Pro His Gly Ala Glu Glu Gly Thr Ala Val
 415                 420                 425                 430

 ccc ccc aag cgg cca tat ggg acc cag cgg acg cct agt acc gcc agc     1525
 Pro Pro Lys Arg Pro Tyr Gly Thr Gln Arg Thr Pro Ser Thr Ala Ser
                 435                 440                 445

 gct aaa aca cat gcc cgt gtg ctg agc atg gat ggg gct ggg ggt gat     1573
 Ala Lys Thr His Ala Arg Val Leu Ser Met Asp Gly Ala Gly Gly Asp
             450                 455                 460

 gtt ctg agg ccc cca ctg gct ggc tgc aag gca gag ctg gag gcc cag     1621
 Val Leu Arg Pro Pro Leu Ala Gly Cys Lys Ala Glu Leu Glu Ala Gln
         465                 470                 475

 gtt ggg gtg gag cag gct gct agt gag cct gtt gtg ctg cct gct gag     1669
 Val Gly Val Glu Gln Ala Ala Ser Glu Pro Val Val Leu Pro Ala Glu
     480                 485                 490

 gcg cga agg gga ccc gct gcc aac cag ccc ggc tgg cgg ggg gag ctg     1717
 Ala Arg Arg Gly Pro Ala Ala Asn Gln Pro Gly Trp Arg Gly Glu Leu
 495                 500                 505                 510

 cag gag gaa ggt gct gtg ggg gga gcg gcc gag gag act ggc agg cgg     1765
 Gln Glu Glu Gly Ala Val Gly Gly Ala Ala Glu Glu Thr Gly Arg Arg
                 515                 520                 525

 gac cgc tca agc agt gtg agg cgg acc cag gcc att cgg aga cgc cac     1813
 Asp Arg Ser Ser Ser Val Arg Arg Thr Gln Ala Ile Arg Arg Arg His
             530                 535                 540

 aat gca ggc agc aac ccc acc cct cca gcc tct gtc atg ggc tcg ccg     1861
 Asn Ala Gly Ser Asn Pro Thr Pro Pro Ala Ser Val Met Gly Ser Pro
         545                 550                 555

 ccc agc agc ctg cag gaa gct cag cgg ggc cgg gct gcc tcc cac tcc     1909
 Pro Ser Ser Leu Gln Glu Ala Gln Arg Gly Arg Ala Ala Ser His Ser
     560                 565                 570

 cgg gcg ctg acg ctg ccc tct gcg ctg cat ttc gcc tct tca ctg ttg     1957
 Arg Ala Leu Thr Leu Pro Ser Ala Leu His Phe Ala Ser Ser Leu Leu
 575                 580                 585                 590

 ctc acc cgg gcc ggt gcc aat gtg cat gag gcc tgc acc ttt gat gac     2005
 Leu Thr Arg Ala Gly Ala Asn Val His Glu Ala Cys Thr Phe Asp Asp
                 595                 600                 605

 act tct gag ggt gca gtg cac tat ttc tac gat gag agc ggt gtg cgg     2053
 Thr Ser Glu Gly Ala Val His Tyr Phe Tyr Asp Glu Ser Gly Val Arg
             610                 615                 620

 cgt tcc tac acc ttt ggc ctg gct gga ggc ggc tac gag aac cct gta     2101
 Arg Ser Tyr Thr Phe Gly Leu Ala Gly Gly Gly Tyr Glu Asn Pro Val
         625                 630                 635

 ggg cag caa ggg gag cag aca gct aat gga gcc tgg gac cga cac tcg     2149
 Gly Gln Gln Gly Glu Gln Thr Ala Asn Gly Ala Trp Asp Arg His Ser
     640                 645                 650

 cat tcc tcc agc ttc cac tcg gct gat gtc cct gag gct aca ggc ggc     2197
 His Ser Ser Ser Phe His Ser Ala Asp Val Pro Glu Ala Thr Gly Gly
 655                 660                 665                 670

 ctg aac ctg ctg cag ccg agg cct gtg gtt ctg cag ggc atg cag gtg     2245
 Leu Asn Leu Leu Gln Pro Arg Pro Val Val Leu Gln Gly Met Gln Val
                 675                 680                 685

 cgc cgg gtg ccc ctg gag atc ccg gag gac tcc ctg cac gaa tcc cag     2293
 Arg Arg Val Pro Leu Glu Ile Pro Glu Asp Ser Leu His Glu Ser Gln
             690                 695                 700

 gag cag aca ctg atg gaa gaa gcg cca ccc cgg gcc cag cat agt tac     2341
 Glu Gln Thr Leu Met Glu Glu Ala Pro Pro Arg Ala Gln His Ser Tyr
         705                 710                 715

 aag tac tgg ctt ctc cct ggc cgc tgg acc tct gtg cgc tat gag cgg     2389
 Lys Tyr Trp Leu Leu Pro Gly Arg Trp Thr Ser Val Arg Tyr Glu Arg
     720                 725                 730

 ctt gcc ctg ctg gct ctg ctg gac cgg acg cgg gga gtg ctg gag aac     2437
 Leu Ala Leu Leu Ala Leu Leu Asp Arg Thr Arg Gly Val Leu Glu Asn
 735                 740                 745                 750

 atc ttc ggc gtg ggc ctg agc agc ctt gtg gcc ttc ctg ggc tac ctg     2485
 Ile Phe Gly Val Gly Leu Ser Ser Leu Val Ala Phe Leu Gly Tyr Leu
                 755                 760                 765

 ctg ctg ctc aag ggc ttc ttc act gac atc tgg gtc ttc cag ttc tgc     2533
 Leu Leu Leu Lys Gly Phe Phe Thr Asp Ile Trp Val Phe Gln Phe Cys
             770                 775                 780

 ctg gtc atc gcc tcc tgc cag tac tcc ttg ctg aag agc gtg cag cct     2581
 Leu Val Ile Ala Ser Cys Gln Tyr Ser Leu Leu Lys Ser Val Gln Pro
         785                 790                 795

 gat gcg gcg tcc ccc atg cac ggc cac aac tgg gtg atc gcg tac agc     2629
 Asp Ala Ala Ser Pro Met His Gly His Asn Trp Val Ile Ala Tyr Ser
     800                 805                 810

 cgt cct gtc tac ttc tgc atc tgc tgt ctg ctc atc tgg ctg ctg gac     2677
 Arg Pro Val Tyr Phe Cys Ile Cys Cys Leu Leu Ile Trp Leu Leu Asp
 815                 820                 825                 830

 gcc ctg ggc tca gct cag ccc ttc cca cct gtc tcc ctc tac ggc ctc     2725
 Ala Leu Gly Ser Ala Gln Pro Phe Pro Pro Val Ser Leu Tyr Gly Leu
                 835                 840                 845

 acg ctc ttc tct gcc tcc ttc ttc ttc tgt gcc cga gac gtg gcc act     2773
 Thr Leu Phe Ser Ala Ser Phe Phe Phe Cys Ala Arg Asp Val Ala Thr
             850                 855                 860

 gtg ttc acc ctg tgc ttc ccc ttc gtc ttc ctc ctg ggc ctc ctg ccc     2821
 Val Phe Thr Leu Cys Phe Pro Phe Val Phe Leu Leu Gly Leu Leu Pro
         865                 870                 875

 cag gtc aac acc tgc ccc aga ccc agg agc ccc cct gag gct ttg cct     2869
 Gln Val Asn Thr Cys Pro Arg Pro Arg Ser Pro Pro Glu Ala Leu Pro
     880                 885                 890

 tgc ctg cat att tgt ttc gct ctt act cag ttt ggg aat tca aat tgt     2917
 Cys Leu His Ile Cys Phe Ala Leu Thr Gln Phe Gly Asn Ser Asn Cys
 895                 900                 905                 910

 cct gca gag gtt cat tcc cct gac cct ttc ccc aca ttg gta aga gta     2965
 Pro Ala Glu Val His Ser Pro Asp Pro Phe Pro Thr Leu Val Arg Val
                 915                 920                 925

 gct ggg ttt ttt aag cca ctc tct gga atc tct ttg tgt tag ggtctcg     3014
 Ala Gly Phe Phe Lys Pro Leu Ser Gly Ile Ser Leu Cys 
             930                 935

 atttgaggac attcatttct tcagcagccc attagcaact gagagcccag ggatgtccta   3074

 caggatagtt tcatagtgac aggtggcact tggctaatag aatatggctg atattgtcat   3134

 taatcatttt gtaccttgac atgggttgtc taataaaact cggacccttc ttgtgaaatc   3194

 agttaaaaaa aaaaaaaa                                                 3212




      <210> 10
      <211> 1650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(1596)

      <400> 10
 accgggccgg aattaccggc tcgacaagta cacaacccgt cagcctgcgc c atg ggc      57
                                                          Met Gly
                                                            1

 tgc gac ggc cgc gtg tcg ggg ctg ctc cgc cgc aac ctg cag ccc acg      105
 Cys Asp Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln Pro Thr
           5                  10                  15

 ctc acc tac tgg agc gtc ttc ttc agc ttc ggc ctg tgc atc gcc ttc      153
 Leu Thr Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile Ala Phe
      20                  25                  30

 ctg ggg ccc acg ctg ctg gac ctg cgc tgt cag acg cac agc tcg ctg      201
 Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser Ser Leu
  35                  40                  45                  50

 ccc cag atc tcc tgg gtc ttc ttc tcg cag cag ctc tgc ctc ctg ctg      249
 Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu Leu Leu
                  55                  60                  65

 ggc agc gcc ctc ggg ggc gtc ttc aaa agg acc ctg gcc cag tca cta      297
 Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln Ser Leu
              70                  75                  80

 tgg gcc ctg ttc acc tcc tct ctg gcc atc tcc ctg gtg ttt gcc gtc      345
 Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe Ala Val
          85                  90                  95

 atc ccc ttc tgc cgc gac gtg aag gtg ctg gcc tca gtc atg gcg ctg      393
 Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met Ala Leu
     100                 105                 110

 gcg ggc ttg gcc atg ggc tgc atc gac acc gtg gcc aac atg cag ctg      441
 Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met Gln Leu
 115                 120                 125                 130

 gta agg atg tac cag aag gac tcg gcc gtc ttc ctc cag gtg ctc cat      489
 Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val Leu His
                 135                 140                 145

 ttc ttc gtg ggc ttt ggt gct ctg ctg agc ccc ctt att gct gac cct      537
 Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala Asp Pro
             150                 155                 160

 ttc ctg tct gag gcc aac tgc ttg cct gcc aat agc acg gcc aac acc      585
 Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Ala Asn Thr
         165                 170                 175

 acc tcc cga ggc cac ctg ttc cat gtc tcc agg gtg ctg ggc cag cac      633
 Thr Ser Arg Gly His Leu Phe His Val Ser Arg Val Leu Gly Gln His
     180                 185                 190

 cac gta gat gcc aag cct tgg tcc aac cag acg ttc cca ggg ctg act      681
 His Val Asp Ala Lys Pro Trp Ser Asn Gln Thr Phe Pro Gly Leu Thr
 195                 200                 205                 210

 cca aag gac ggg gca ggg acc cga gtg tcc tat gcc ttc tgg atc atg      729
 Pro Lys Asp Gly Ala Gly Thr Arg Val Ser Tyr Ala Phe Trp Ile Met
                 215                 220                 225

 gcc ctc atc aat ctt cca gtg ccc atg gct gtg ctg atg ctg ctg tcc      777
 Ala Leu Ile Asn Leu Pro Val Pro Met Ala Val Leu Met Leu Leu Ser
             230                 235                 240

 aag gag cgg ctg ctg acc tgc tgt ccc cag agg agg ccc ctg ctt ctg      825
 Lys Glu Arg Leu Leu Thr Cys Cys Pro Gln Arg Arg Pro Leu Leu Leu
         245                 250                 255

 tct gct gat gag ctt gcc ttg gag aca cag cct cct gag aag gaa gat      873
 Ser Ala Asp Glu Leu Ala Leu Glu Thr Gln Pro Pro Glu Lys Glu Asp
     260                 265                 270

 gcc tcc tca ctg ccc cca aag ttt cag tca cac cta ggg cat gag gac      921
 Ala Ser Ser Leu Pro Pro Lys Phe Gln Ser His Leu Gly His Glu Asp
 275                 280                 285                 290

 ctg ttc agc tgc tgc caa agg aag aac ctc aga gga gcc cct tat tcc      969
 Leu Phe Ser Cys Cys Gln Arg Lys Asn Leu Arg Gly Ala Pro Tyr Ser
                 295                 300                 305

 ttc ttt gcc atc cac atc acg ggc gcc ctg gta ctg ttc atg acg gat     1017
 Phe Phe Ala Ile His Ile Thr Gly Ala Leu Val Leu Phe Met Thr Asp
             310                 315                 320

 ggg ttg acg ggt gcc tat tcc gcc ttc gtg tac agc tat gct gtg gag     1065
 Gly Leu Thr Gly Ala Tyr Ser Ala Phe Val Tyr Ser Tyr Ala Val Glu
         325                 330                 335

 aag ccc ctg tct gtg gga cac aag gtg gct ggc tac ctc ccc agc ctc     1113
 Lys Pro Leu Ser Val Gly His Lys Val Ala Gly Tyr Leu Pro Ser Leu
     340                 345                 350

 ttc tgg ggc ttc atc aca ctg ggc cgg ctc ctc tcc att ccc ata tcc     1161
 Phe Trp Gly Phe Ile Thr Leu Gly Arg Leu Leu Ser Ile Pro Ile Ser
 355                 360                 365                 370

 tca aga atg aag ccg gcc acc atg gtt ttc atc aac gtg gtt ggc gtg     1209
 Ser Arg Met Lys Pro Ala Thr Met Val Phe Ile Asn Val Val Gly Val
                 375                 380                 385

 gtg gtg acg ttc ctg gtg ctg ctt att ttc tcc tac aac gtc gtc ttc     1257
 Val Val Thr Phe Leu Val Leu Leu Ile Phe Ser Tyr Asn Val Val Phe
             390                 395                 400

 ctg ttc gtg ggg acg gca agc ctg ggc ctg ttt ctc agc agc acc ttc     1305
 Leu Phe Val Gly Thr Ala Ser Leu Gly Leu Phe Leu Ser Ser Thr Phe
         405                 410                 415

 ccc agc atg ctg gcc tac acg gag gac tcg ctg cag tac aaa ggc tgt     1353
 Pro Ser Met Leu Ala Tyr Thr Glu Asp Ser Leu Gln Tyr Lys Gly Cys
     420                 425                 430

 gca acc aca gtg ctg gtg aca ggg gca gga gtt ggc gag atg gtg ctg     1401
 Ala Thr Thr Val Leu Val Thr Gly Ala Gly Val Gly Glu Met Val Leu
 435                 440                 445                 450

 cag atg ctg gtt ggt tcg ata ttc cag gct cag ggc agc tat agt ttc     1449
 Gln Met Leu Val Gly Ser Ile Phe Gln Ala Gln Gly Ser Tyr Ser Phe
                 455                 460                 465

 ctg gtc tgt ggc gtg atc ttt ggt tgt ctg gct ttt acc ttc tat atc     1497
 Leu Val Cys Gly Val Ile Phe Gly Cys Leu Ala Phe Thr Phe Tyr Ile
             470                 475                 480

 ttg ctc ctg ttt ttc cac agg atg cac cct gga ctc cca tca gtt cct     1545
 Leu Leu Leu Phe Phe His Arg Met His Pro Gly Leu Pro Ser Val Pro
         485                 490                 495

 acc caa gac aga tca att gga atg gaa aac tct gag tgc tac cag agg     1593
 Thr Gln Asp Arg Ser Ile Gly Met Glu Asn Ser Glu Cys Tyr Gln Arg
     500                 505                 510

 taa aact gggtgaagaa ggcaagagaa gactttcagc ctcttgatca ccagcacgac     1650
 






      <210> 11
      <211> 1284
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(1234)

      <400> 11
 gcccacctgt cctgcagcac tggatgcttt gtgagttggg gattgttgcg tcccatatct     60

 ggacccagaa gggacttccc tgctcggctg gctctcggtt tctctgcttt cctccggaga    120

 aataacagcg tcttccgcgc cgcgc  atg gag cct ccc ggc cgc cgc gag tgt     172
                              Met Glu Pro Pro Gly Arg Arg Glu Cys
                                1               5

 ccc ttt cct tcc tgg cgc ttt cct ggg ttg ctt ctg gcg gcc atg gtg      220
 Pro Phe Pro Ser Trp Arg Phe Pro Gly Leu Leu Leu Ala Ala Met Val
  10                  15                  20                  25

 ttg ctg ctg tac tcc ttc tcc gat gcc tgt gag gag cca cca aca ttt      268
 Leu Leu Leu Tyr Ser Phe Ser Asp Ala Cys Glu Glu Pro Pro Thr Phe
                  30                  35                  40

 gaa gct atg gag ctc att ggt aaa cca aaa ccc tac tat gag att ggt      316
 Glu Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr Tyr Glu Ile Gly
              45                  50                  55

 gaa cga gta gat tat aag tgt aaa aaa gga tac ttc tat ata cct cct      364
 Glu Arg Val Asp Tyr Lys Cys Lys Lys Gly Tyr Phe Tyr Ile Pro Pro
          60                  65                  70

 ctt gcc acc cat act att tgt gat cgg aat cat aca tgg cta cct gtc      412
 Leu Ala Thr His Thr Ile Cys Asp Arg Asn His Thr Trp Leu Pro Val
      75                  80                  85

 tca gat gac gcc tgt tat aga gaa aca tgt cca tat ata cgg gat cct      460
 Ser Asp Asp Ala Cys Tyr Arg Glu Thr Cys Pro Tyr Ile Arg Asp Pro
  90                  95                 100                 105

 tta aat ggc caa gca gtc cct gca aat ggg act tac gag ttt ggt tat      508
 Leu Asn Gly Gln Ala Val Pro Ala Asn Gly Thr Tyr Glu Phe Gly Tyr
                 110                 115                 120

 cag atg cac ttt att tgt aat gag ggt tat tac tta att ggt gaa gaa      556
 Gln Met His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu Ile Gly Glu Glu
             125                 130                 135

 att cta tat tgt gaa ctt aaa gga tca gta gca att tgg agc ggt aag      604
 Ile Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Ile Trp Ser Gly Lys
         140                 145                 150

 ccc cca ata tgt gaa aag gtt ttg tgt aca cca cct cca aaa ata aaa      652
 Pro Pro Ile Cys Glu Lys Val Leu Cys Thr Pro Pro Pro Lys Ile Lys
     155                 160                 165

 aat gga aaa cac acc ttt agt gaa gta gaa gta ttt gag tat ctt gat      700
 Asn Gly Lys His Thr Phe Ser Glu Val Glu Val Phe Glu Tyr Leu Asp
 170                 175                 180                 185

 gca gta act tat agt tgt gat cct gca cct gga cca gat cca ttt tca      748
 Ala Val Thr Tyr Ser Cys Asp Pro Ala Pro Gly Pro Asp Pro Phe Ser
                 190                 195                 200

 ctt att gga gag agc acg att tat tgt ggt gac aat tca gtg tgg agt      796
 Leu Ile Gly Glu Ser Thr Ile Tyr Cys Gly Asp Asn Ser Val Trp Ser
             205                 210                 215

 cgt gct gct cca gag tgt aaa gtg gtc aaa tgt cga ttt cca gta gtc      844
 Arg Ala Ala Pro Glu Cys Lys Val Val Lys Cys Arg Phe Pro Val Val
         220                 225                 230

 gaa aat gga aaa cag ata tca gga ttt gga aaa aaa ttt tac tac aaa      892
 Glu Asn Gly Lys Gln Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr Lys
     235                 240                 245

 gca aca gtt atg ttt gaa tgc gat aag ggt ttt tac ctc gat ggc agc      940
 Ala Thr Val Met Phe Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly Ser
 250                 255                 260                 265

 gac aca att gtc tgt gac agt aac agt act tgg gat ccc cca gtt cca      988
 Asp Thr Ile Val Cys Asp Ser Asn Ser Thr Trp Asp Pro Pro Val Pro
                 270                 275                 280

 aag tgt ctt aaa ggt cct agg cct act tac aag cct cca gtc tca aat     1036
 Lys Cys Leu Lys Gly Pro Arg Pro Thr Tyr Lys Pro Pro Val Ser Asn
             285                 290                 295

 tat cca gga tat cct aaa cct gag gaa gga ata ctt gac agt ttg gat     1084
 Tyr Pro Gly Tyr Pro Lys Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp
         300                 305                 310

 gtt tgg gtc att gct gtg att gtt att gcc ata gtt gtt gga gtt gca     1132
 Val Trp Val Ile Ala Val Ile Val Ile Ala Ile Val Val Gly Val Ala
     315                 320                 325

 gta att tgt gtt gtc ccg tac aga tat ctt caa agg agg aag aag aaa     1180
 Val Ile Cys Val Val Pro Tyr Arg Tyr Leu Gln Arg Arg Lys Lys Lys
 330                 335                 340                 345

 ggc aca tac cta act gat gag acc cac aga gaa gta aaa ttt act tct     1228
 Gly Thr Tyr Leu Thr Asp Glu Thr His Arg Glu Val Lys Phe Thr Ser
                 350                 355                 360

 ctc tga gaaggagaga tgagagaaag gtttgctttt atcattaaaa ggaaagcaga      1284
 Leu 






      <210> 12
      <211> 2301
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (294)..(881)

      <400> 12
 actgtttatg accagtggtt catcaccctt tttaacattg tttacacatc actgcctgtt     60

 ttagccatgg ggatttttga ccaggatgtg agtgaccaga acagcgtgga ctgtccccag    120

 ctctacaaac caggacagct gaatctgctt tttaacaagc gtaaattttc catttgcgtg    180

 ttgcatggaa tctacacctc attagtcctt ttcttcatcc cctatggggc cttttacaac    240

 gtggctggag aagatgggca acatattgct gactaccagt cctctgcagt tac   atg     296
                                                              Met
                                                                1

 gcc aca tct ttg gtc att gtg gtc agt gtg cag ata gcc ttg gat acc      344
 Ala Thr Ser Leu Val Ile Val Val Ser Val Gln Ile Ala Leu Asp Thr
               5                  10                  15

 agt tac tgg act ttc att aat cac gtc ttc atc tgg ggg agc att gcc      392
 Ser Tyr Trp Thr Phe Ile Asn His Val Phe Ile Trp Gly Ser Ile Ala
          20                  25                  30

 att tat ttc tcc att tta ttt aca atg cac agt aat ggc atc ttt ggc      440
 Ile Tyr Phe Ser Ile Leu Phe Thr Met His Ser Asn Gly Ile Phe Gly
      35                  40                  45

 atc ttc cca aac cag ttt cca ttt gtt ggt aat gca cga cat tcc ctg      488
 Ile Phe Pro Asn Gln Phe Pro Phe Val Gly Asn Ala Arg His Ser Leu
  50                  55                  60                  65

 acc cag aag tgc atc tgg ctt gta att ctc tta aca aca gtg gct tca      536
 Thr Gln Lys Cys Ile Trp Leu Val Ile Leu Leu Thr Thr Val Ala Ser
                  70                  75                  80

 gtt atg cca gtg gtg gca ttc aga ttt ttg aag gtg gat tta tac cca      584
 Val Met Pro Val Val Ala Phe Arg Phe Leu Lys Val Asp Leu Tyr Pro
              85                  90                  95

 acc ctg agt gat cag atc cgc cgg tgg cag aag gct caa aag aag gca      632
 Thr Leu Ser Asp Gln Ile Arg Arg Trp Gln Lys Ala Gln Lys Lys Ala
         100                 105                 110

 agg cct cca agt agc cga agg cct cgg acc cgc agg tca agc tca aga      680
 Arg Pro Pro Ser Ser Arg Arg Pro Arg Thr Arg Arg Ser Ser Ser Arg
     115                 120                 125

 agg tct gga tat gct ttt gct cac caa gaa ggc tat gga gag ctt atc      728
 Arg Ser Gly Tyr Ala Phe Ala His Gln Glu Gly Tyr Gly Glu Leu Ile
 130                 135                 140                 145

 aca tct gga aaa aat atg cga gct aaa aat cca ccc cca aca tca ggg      776
 Thr Ser Gly Lys Asn Met Arg Ala Lys Asn Pro Pro Pro Thr Ser Gly
                 150                 155                 160

 ctg gaa aag aca cat tat aat agc act agc tgg att gaa aat tta tgt      824
 Leu Glu Lys Thr His Tyr Asn Ser Thr Ser Trp Ile Glu Asn Leu Cys
             165                 170                 175

 aag aaa acc aca gac acc gtg agc agc ttt agc cag gat aaa aca gtg      872
 Lys Lys Thr Thr Asp Thr Val Ser Ser Phe Ser Gln Asp Lys Thr Val
         180                 185                 190

 aaa ctg tga gtcaata tgaatttaaa ccacgtagtt atcttttcac ttcaggtgga      928
 Lys Leu 
     195

 gctgaaattc tgctggctcc agagtttgag atttgaggca agaggtgggg caggcagatt    988

 gcctcactta acttaaatct gcggcagaca actgccagtg cccatcaaac aggagtgtgc   1048

 gctatggaaa accaggccag agggtcactg tctggtttgt gatttggtgg acaaaacact   1108

 cgctgttaca agtacagatt tttttttttt ttaaatcaac ctagatacca attgacctga   1168

 actttagaat cttatttatg gagaaaaact tgtaaagctg catattcact gaatggatcc   1228

 tcaggcggat aaaagggtgc attttaaagg tatatatcca agctgaaaag catgcctatt   1288

 gacagataaa catgtatctg taagatcagc ctttcccaag gtatactttt aaaatttaaa   1348

 gcgtgtactg tgttgctttc agactgagtt gcatgtcact ctttagtctt gatatctacc   1408

 tgtctgttca gccaggacaa caaatggctt ccaagcctga agaatacaaa agtgtgcttg   1468

 tgtttctcat ttttatacca gtctagggac aaaggagact gaacatcttt gcagcaggat   1528

 aggctggtaa tttgatcaaa tttattcaaa aagctctcag tctgtgtcat gtaaggacat   1588

 gcttatgaaa tgtgagagag gctcgccact aagtattcta aatacttttc aatggctttt   1648

 ctaacaacct cagtagtaat ttgctgagca tcatccagac cattaataga atcagcaaag   1708

 cactggaatt tcacacttta atgataatat tccacatagt ctatgggcaa atattttcaa   1768

 catttccaat ttttaaagct tcagaattga agccaaacaa attaataaat aattgtttta   1828

 attactattt aaaaactcag gtttagattg tttaaaatta gttgcttttg atactcagct   1888

 gtcatgttta taattcaaac atgtagtaaa catatgtagg taaggttgtt tttttggaga   1948

 tgttgcagct caaatttcag tccacatatg aatcatcagt gtattttcca taaagtgatt   2008

 cgggcatatt tgtgtgaaaa cctcagttct gtcacttctt acctctataa acttggacga   2068

 taatgtgcct tctctgagac tcagtttctt cctctgtaaa atgaggacat actacctacc   2128

 tcatgtggtt ggttgatgat tgtctgtcca agcacaaact ctgaaattat taaaaacata   2188

 attatttcat aaacagatga gttaagttcc agttaactca acatcagtat aacagagcaa   2248

 ttggaaaaag atatgaaaaa actggaatct aaataggcag gggaggaagg ctt          2301




      <210> 13
      <211> 931
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(562)

      <400> 13
 atgtcagagc tgccggagtg gggctcattc ttttctgctt gtcagtgcag tgaccttcct     60

 cacctagatg acctggaaaa tattcctgcc agtcacgtgg gtcttgtcct gtccccagag    120

 ccttgggtca catggctcat tgtgcctgcg ctgccagcag ccaggagcca ggagccaaga    180

 gcagagcgcc agc   atg aac ttg ggg gtc agc atg ctg agg atc ctc ttc     229
                  Met Asn Leu Gly Val Ser Met Leu Arg Ile Leu Phe
                    1               5                  10

 ctc ctg gat gta gga gga gct caa gtg ctg gca aca ggc aag acc cct      277
 Leu Leu Asp Val Gly Gly Ala Gln Val Leu Ala Thr Gly Lys Thr Pro
          15                  20                  25

 ggg gct gaa att gat ttc aag tac gcc ctc atc ggg act gct gtg ggt      325
 Gly Ala Glu Ile Asp Phe Lys Tyr Ala Leu Ile Gly Thr Ala Val Gly
      30                  35                  40

 gtc gcc ata tct gct ggc ttc ctg gcc ctg aag atc tgc atg atc agg      373
 Val Ala Ile Ser Ala Gly Phe Leu Ala Leu Lys Ile Cys Met Ile Arg
  45                  50                  55                  60

 agg cac tta ttt gac gac gac tct tcc gac ctg aaa agc acg cct ggg      421
 Arg His Leu Phe Asp Asp Asp Ser Ser Asp Leu Lys Ser Thr Pro Gly
                  65                  70                  75

 ggc ctc agt ggt gag gga tgt ggt gct cgg gcc tgg ctc tgc ccc acc      469
 Gly Leu Ser Gly Glu Gly Cys Gly Ala Arg Ala Trp Leu Cys Pro Thr
              80                  85                  90

 cag cga ggc acc gag ggc cac tct gtg atg ctg gct aca gca aga atg      517
 Gln Arg Gly Thr Glu Gly His Ser Val Met Leu Ala Thr Ala Arg Met
          95                 100                 105

 aac cca cag gcg cag agc cca aca ggc tgt aaa gga agg cag tga cct      565
 Asn Pro Gln Ala Gln Ser Pro Thr Gly Cys Lys Gly Arg Gln 
     110                 115                 120

 ctgcatgttt ctgtctctct cactaaccct ttgcctctgt ttctctttct tctgtctcta    625

 tctctctctg tctctctatt tgtgttcctt tttctgtctc cctttccatg tctctgtctt    685

 tctgtgtctc tttccctctg tacttttcct ttcagttgct cttggcagtc ctgagaatca    745

 catttcctgg agaaaggtgg gagaggaact aaaattggct tcacacagaa atttctgttc    805

 tctcatccaa atgatgagat caaataaacc cagtcccagt aggcagcgag gttggtccta    865

 agtgtgggcg gatggtggga ggttctgttg acactgcctt tgtgggtcaa gatgaatttt    925

 ttttcc                                                               931




      <210> 14
      <211> 1539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(1260)

      <400> 14
 cttgcttacc acaactgaga gtggggagtc agttcgaggc ctagcatcac ttaaacttcc     60

 tccaaaggca caaaagccag cacgagaaaa     atg aag acg gga cat ttt gaa     111
                                      Met Lys Thr Gly His Phe Glu
                                        1               5

 ata gtc acc atg ctg ctg gca acc atg att cta gtg gac att ttc cag      159
 Ile Val Thr Met Leu Leu Ala Thr Met Ile Leu Val Asp Ile Phe Gln
          10                  15                  20

 gtg aag gct gaa gtg tta gac atg gca gat aat gca ttt gat gat gaa      207
 Val Lys Ala Glu Val Leu Asp Met Ala Asp Asn Ala Phe Asp Asp Glu
      25                  30                  35

 tac ctg aaa tgt acg gac agg atg gaa att aaa tac gtt ccc caa ctg      255
 Tyr Leu Lys Cys Thr Asp Arg Met Glu Ile Lys Tyr Val Pro Gln Leu
  40                  45                  50                  55

 cta aag gag gaa aaa gca agc cac cag caa tta gat act gtg tgg gaa      303
 Leu Lys Glu Glu Lys Ala Ser His Gln Gln Leu Asp Thr Val Trp Glu
                  60                  65                  70

 aat gca aaa gcc aaa tgg gca gcc cga aag act caa atc ttt ctc cct      351
 Asn Ala Lys Ala Lys Trp Ala Ala Arg Lys Thr Gln Ile Phe Leu Pro
              75                  80                  85

 atg aat ttt aag gat aac cat gga ata gcc ctg atg gca tat att tcc      399
 Met Asn Phe Lys Asp Asn His Gly Ile Ala Leu Met Ala Tyr Ile Ser
          90                  95                 100

 gaa gct caa gag caa act ccc ttt tac cat ctg ttc agt gaa gct gtg      447
 Glu Ala Gln Glu Gln Thr Pro Phe Tyr His Leu Phe Ser Glu Ala Val
     105                 110                 115

 aag atg gct ggc caa tct cga gaa gat tat atc tat ggc ttc cag ttc      495
 Lys Met Ala Gly Gln Ser Arg Glu Asp Tyr Ile Tyr Gly Phe Gln Phe
 120                 125                 130                 135

 aaa gct ttc cac ttt tac ctc aca aga gcc ctg cag ttg ctg aga aaa      543
 Lys Ala Phe His Phe Tyr Leu Thr Arg Ala Leu Gln Leu Leu Arg Lys
                 140                 145                 150

 cct tgt gag gcc agt tcc aaa act gtg gta tat aga aca agc cag ggc      591
 Pro Cys Glu Ala Ser Ser Lys Thr Val Val Tyr Arg Thr Ser Gln Gly
             155                 160                 165

 act tca ttt aca ttt gga ggg cta aac caa gcc agg ttt ggc cat ttt      639
 Thr Ser Phe Thr Phe Gly Gly Leu Asn Gln Ala Arg Phe Gly His Phe
         170                 175                 180

 acc ttg gca tat tca gcc aaa cct cag gct gct aat gac cag ctc act      687
 Thr Leu Ala Tyr Ser Ala Lys Pro Gln Ala Ala Asn Asp Gln Leu Thr
     185                 190                 195

 gtg tta tcc atc tac aca tgc ctt gga gtt gac att gaa aat ttt ctt      735
 Val Leu Ser Ile Tyr Thr Cys Leu Gly Val Asp Ile Glu Asn Phe Leu
 200                 205                 210                 215

 gat aaa gaa agt gaa aga att act tta ata cct ctg aat gag gtt ttt      783
 Asp Lys Glu Ser Glu Arg Ile Thr Leu Ile Pro Leu Asn Glu Val Phe
                 220                 225                 230

 caa gtg tca cag gag ggg gct ggc aat aac ctt atc ctt caa agc ata      831
 Gln Val Ser Gln Glu Gly Ala Gly Asn Asn Leu Ile Leu Gln Ser Ile
             235                 240                 245

 aac aag acc tgc agc cat tat gag tgt gca ttt cta ggt gga cta aaa      879
 Asn Lys Thr Cys Ser His Tyr Glu Cys Ala Phe Leu Gly Gly Leu Lys
         250                 255                 260

 acc gaa aac tgt att gag aac cta gaa tat ttt caa ccc atc tat gtc      927
 Thr Glu Asn Cys Ile Glu Asn Leu Glu Tyr Phe Gln Pro Ile Tyr Val
     265                 270                 275

 tac aac cct ggt gag aaa aac cag aag ctt gaa gac cat agt gag aaa      975
 Tyr Asn Pro Gly Glu Lys Asn Gln Lys Leu Glu Asp His Ser Glu Lys
 280                 285                 290                 295

 aac tgg aag ctt gaa gac cat ggt gag aaa aac cag aag ctt gaa gac     1023
 Asn Trp Lys Leu Glu Asp His Gly Glu Lys Asn Gln Lys Leu Glu Asp
                 300                 305                 310

 cat ggt gtg aaa atc ctt gaa ccc acc caa ata cct gga atg aaa att     1071
 His Gly Val Lys Ile Leu Glu Pro Thr Gln Ile Pro Gly Met Lys Ile
             315                 320                 325

 cca gaa cct ttt cca cta cct gaa gat aaa agt caa gga aat atc aac     1119
 Pro Glu Pro Phe Pro Leu Pro Glu Asp Lys Ser Gln Gly Asn Ile Asn
         330                 335                 340

 aat cct act cca ggt cca gtt cct gtt cca ggt ccc aaa agc cat cct     1167
 Asn Pro Thr Pro Gly Pro Val Pro Val Pro Gly Pro Lys Ser His Pro
     345                 350                 355

 tct gca tcc tcg ggc aaa ctg ctg ctt cca cag ttt ggg atg gtc atc     1215
 Ser Ala Ser Ser Gly Lys Leu Leu Leu Pro Gln Phe Gly Met Val Ile
 360                 365                 370                 375

 att tta atc agt gtt tct gct ata aat ctc ttt gtt gct ctg tag ttt     1263
 Ile Leu Ile Ser Val Ser Ala Ile Asn Leu Phe Val Ala Leu 
                 380                 385

 gatgcattgt ttatctttct tattctttac ttgaaataac tatagggatc cacaggagat   1323

 caaaaggaat gatgtatttt ttacgtgttg gccaaagtca ctggataaaa tgagaattgt   1383

 atatttgtta ttcattttgc aaattcagaa agttggtcca gatatatgtc acagaacttt   1443

 tcacttgtat actactctta caatggaaaa aaatcccgaa aactgtatac ttctgattaa   1503

 attcaataaa agattttgat tagaaaaaaa aaaaaa                             1539




      <210> 15
      <211> 787
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(558)

      <400> 15
 gcctgcagga ttcggcacga gggccgg    atg ggg aag gcg gcg gcg gcg gtg      51
                                  Met Gly Lys Ala Ala Ala Ala Val
                                    1               5

 gcc ttt ggg gcc gaa gtg ggc gtg cgg ctc gcg ctg ttc gcg gcc ttc       99
 Ala Phe Gly Ala Glu Val Gly Val Arg Leu Ala Leu Phe Ala Ala Phe
      10                  15                  20

 ctg gtg acg gag ctg ctc ccc ccg ttc cag aga ctc atc cag ccg gag      147
 Leu Val Thr Glu Leu Leu Pro Pro Phe Gln Arg Leu Ile Gln Pro Glu
  25                  30                  35                  40

 gag atg tgg ctc tac cgg aac ccc tac gtg gag gcg gag tat ttc ccc      195
 Glu Met Trp Leu Tyr Arg Asn Pro Tyr Val Glu Ala Glu Tyr Phe Pro
                  45                  50                  55

 acc aag ccg atg ttt gtt att gca ttt ctc tct cca ctg tct ctg atc      243
 Thr Lys Pro Met Phe Val Ile Ala Phe Leu Ser Pro Leu Ser Leu Ile
              60                  65                  70

 ttc ctg gcc aaa ttt ctc aag aag gca gac aca aga gac agc aga caa      291
 Phe Leu Ala Lys Phe Leu Lys Lys Ala Asp Thr Arg Asp Ser Arg Gln
          75                  80                  85

 gcc tgc ctg gct gcc agc ctt gcc ctg gct ctg aat ggc gtc ttt acc      339
 Ala Cys Leu Ala Ala Ser Leu Ala Leu Ala Leu Asn Gly Val Phe Thr
      90                  95                 100

 aac aca ata aaa ctg atc gta ggg agg cca cgc cca gat ttc ttc tac      387
 Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr
 105                 110                 115                 120

 cgc tgc ttc cct gat ggg cta gcc cat tct gac ttg atg tgt aca ggg      435
 Arg Cys Phe Pro Asp Gly Leu Ala His Ser Asp Leu Met Cys Thr Gly
                 125                 130                 135

 gat aag gac gtg gtg aat gag ggc cga aag agc ttc ccc agt gga cat      483
 Asp Lys Asp Val Val Asn Glu Gly Arg Lys Ser Phe Pro Ser Gly His
             140                 145                 150

 tct tcc tgt atg aat atc ata tgg act cta ccc tat gct tgt ttt cac      531
 Ser Ser Cys Met Asn Ile Ile Trp Thr Leu Pro Tyr Ala Cys Phe His
         155                 160                 165

 atc att gaa ttt aac cta gaa agc tag taggg atgggaaaat ctgactactc      583
 Ile Ile Glu Phe Asn Leu Glu Ser 
     170                 175

 ttgtttctac aatttggaaa atcccccctt ctttagtaac tccacagttt aacaagtctg    643

 agccttgact atttgggtaa atattacaga acagaaaggt agtttacctt catgagattt    703

 gcacatttaa ttgttatatt atttgcctag atcctgcaat cttgtactag caataaaaat    763

 acctttaacg aaaaaaaaaa aaaa                                           787




      <210> 16
      <211> 1967
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (338)..(763)

      <400> 16
 cgagcggccg ggaggtgggg agaaaaggcg agacttttgt gggtgctccc gatcgccagt     60

 agttccttca gtctcagccg ccaactccgg aggcgcggtg ctcggcccgg gagcgcgagc    120

 gggaggagca gagacccgca gccgggagcc cgagcgcggg cgatgcaggc tccgcgagcg    180

 gcacctgcgg ctcctctaag ctacgaccgt cgtctccgcg gcagcagcgc gggccccagc    240

 agcctcggca gccacagccg ctgcagccgg ggcagcctcc gctgctgtcg cctcctctga    300

 tgcgcttgcc ctctcccggc cccgggactc cgggaga atg tgg gtc cta ggc atc     355
                                          Met Trp Val Leu Gly Ile
                                            1               5

 gcg gca act ttt tgc gga ttg ttc ttg ctt cca ggc ttt gcg ctg caa      403
 Ala Ala Thr Phe Cys Gly Leu Phe Leu Leu Pro Gly Phe Ala Leu Gln
              10                  15                  20

 atc cag tgc tac cag tgt gaa gaa ttc cag ctg aac aac gac tgc tcc      451
 Ile Gln Cys Tyr Gln Cys Glu Glu Phe Gln Leu Asn Asn Asp Cys Ser
          25                  30                  35

 tcc ccc gag ttc att gtg aat tgc acg gtg aac gtt caa gac atg tgt      499
 Ser Pro Glu Phe Ile Val Asn Cys Thr Val Asn Val Gln Asp Met Cys
      40                  45                  50

 cag aaa gaa gtg atg gag caa agt gcc ggg atc atg tac cgc aag tcc      547
 Gln Lys Glu Val Met Glu Gln Ser Ala Gly Ile Met Tyr Arg Lys Ser
  55                  60                  65                  70

 tgt gca tca tca gcg gcc tgt ctc atc gcc tct gcc ggg tac cag tcc      595
 Cys Ala Ser Ser Ala Ala Cys Leu Ile Ala Ser Ala Gly Tyr Gln Ser
                  75                  80                  85

 ttc tgc tcc cca ggg aaa ctg aac tca gtt tgc atc agc tgc tgc aac      643
 Phe Cys Ser Pro Gly Lys Leu Asn Ser Val Cys Ile Ser Cys Cys Asn
              90                  95                 100

 acc cct ctt tgt aac ggg cca agg ccc aag aaa agg gga agt tct gcc      691
 Thr Pro Leu Cys Asn Gly Pro Arg Pro Lys Lys Arg Gly Ser Ser Ala
         105                 110                 115

 tcg gcc ctc agg cca ggg ctc cgc acc acc atc ctg ttc ctc aaa tta      739
 Ser Ala Leu Arg Pro Gly Leu Arg Thr Thr Ile Leu Phe Leu Lys Leu
     120                 125                 130

 gcc ctc ttc tcg gca cac tgc tga agctgaagga gatgccaccc cctcctgcat     793
 Ala Leu Phe Ser Ala His Cys 
 135                 140

 tgttcttcca gccctcgccc ccaacccccc acctccctga gtgagtttct tctgggtgtc    853

 cttttattct gggtagggag cgggagtccg tgttctcttt tgttcctgtg caaataatga    913

 aagagctcgg taaagcattc tgaataaatt cagcttgact gaattttcag tatgtacttg    973

 aaggaaggag gtggagtgaa agttcacccc catgtctgtg taaccggagt caaggccagg   1033

 ctggcagagt cagtccttag aagtcactga ggtgggcatc tgccttttgt aaagcctcca   1093

 gtgtccattc catccctgat gggggcatag tttgagactg cagagtgaga gtgacgtttt   1153

 cttagggctg gagggccagt tcccactcaa ggctccctcg cttgacattc aaacttcatg   1213

 ctcctgaaaa ccattctctg cagcagaatt ggctggtttc gcgcctgagt tgggctctag   1273

 tgactcgaga ctcaatgact gggacttaga ctggggctcg gcctcgctct gaaaagtgct   1333

 taagaaaatc ttctcagttc tccttgcaga ggactggcgc cgggacgcga agagcaacgg   1393

 gcgctgcaca aagcgggcgc tgtcggtggt ggagtgcgca tgtacgcgca ggcgcttctc   1453

 gtggttggcg tgctgcagcg acaggcggca gcacagcacc tgcacgaaca cccgccgaaa   1513

 ctgctgcgag gacaccgtgt acaggagcgg gttgatgacc gagctgaggt agaaaaacgt   1573

 ctccgagaag gggaggagga tcatgtacgc ccggaagtag gacctcgtcc agtcgtgctt   1633

 gggtttggcc gcagccatga tcctccgaat ctggttgggc atccagcata cggccaatgt   1693

 cacaacaatc agccctgggc agacacgagc aggagggaga gacagagaaa agaaaaacac   1753

 agcatgagaa cacagtaaat aaataaaacc ataaaatatt tagcccctct gttctgtgct   1813

 tactggccag gaaatggtac caatttttca gtgttggact tgacagcttc ttttgccaca   1873

 agcaagagag aatttaacac tgtttcaaac ccgggggagt tggctgtgtt aaagaaagac   1933

 cattaaatgc tttagacagt gtaaaaaaaa aaaa                               1967




      <210> 17
      <211> 925
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(663)

      <400> 17
  atg gct tta atc ttt aga aca gca atg caa tct gtt gga ctt tta cta      48
  Met Ala Leu Ile Phe Arg Thr Ala Met Gln Ser Val Gly Leu Leu Leu
    1               5                  10                  15

 tct ctc ctg gga tgg att tta tcc att att aca act tat ttg cca cac       96
 Ser Leu Leu Gly Trp Ile Leu Ser Ile Ile Thr Thr Tyr Leu Pro His
              20                  25                  30

 tgg aag aac ctc aac ctg gac tta aat gaa atg gaa aac tgg acc atg      144
 Trp Lys Asn Leu Asn Leu Asp Leu Asn Glu Met Glu Asn Trp Thr Met
          35                  40                  45

 gga ctc tgg caa acc tgt gtc atc caa gag gaa gtg ggg atg caa tgc      192
 Gly Leu Trp Gln Thr Cys Val Ile Gln Glu Glu Val Gly Met Gln Cys
      50                  55                  60

 aag gac ttt gac tcc ttc ctg gct ttg cct gct gaa ctc agg gtc tcc      240
 Lys Asp Phe Asp Ser Phe Leu Ala Leu Pro Ala Glu Leu Arg Val Ser
  65                  70                  75                  80

 agg atc tta atg ttt ctg tca aat ggg ctg gga ttt ctg ggc ctg ctg      288
 Arg Ile Leu Met Phe Leu Ser Asn Gly Leu Gly Phe Leu Gly Leu Leu
                  85                  90                  95

 gtc tct ggg ttt ggc ctg gac tgt ttg aga att gga gag agt cag aga      336
 Val Ser Gly Phe Gly Leu Asp Cys Leu Arg Ile Gly Glu Ser Gln Arg
             100                 105                 110

 gat ctc aag agg cga ctg ctc att ctg gga gga att ctg tcc tgg gcc      384
 Asp Leu Lys Arg Arg Leu Leu Ile Leu Gly Gly Ile Leu Ser Trp Ala
         115                 120                 125

 tcg gga atc aca gcc ctg gtt ccc gtc tct tgg gtt gcc cac aag acg      432
 Ser Gly Ile Thr Ala Leu Val Pro Val Ser Trp Val Ala His Lys Thr
     130                 135                 140

 gtt cag gag ttc tgg gat gag aac gtc cca gac ttt gtc ccc agg agg      480
 Val Gln Glu Phe Trp Asp Glu Asn Val Pro Asp Phe Val Pro Arg Arg
 145                 150                 155                 160

 gtg tct gct cca ctg tgc agc ctg ctc cag cca cgc tcc cct agc ttc      528
 Val Ser Ala Pro Leu Cys Ser Leu Leu Gln Pro Arg Ser Pro Ser Phe
                 165                 170                 175

 ggg cca cta cgc agt ggc aca aac aca aga tca tca tca aga act gga      576
 Gly Pro Leu Arg Ser Gly Thr Asn Thr Arg Ser Ser Ser Arg Thr Gly
             180                 185                 190

 gac gag aaa cac caa cct gaa aca cta agc cag aaa gga caa gcg tct      624
 Asp Glu Lys His Gln Pro Glu Thr Leu Ser Gln Lys Gly Gln Ala Ser
         195                 200                 205

 gct gtt cag gag acg ctt gct caa cac tgg att tgg tag gatgtcccgc       673
 Ala Val Gln Glu Thr Leu Ala Gln His Trp Ile Trp 
     210                 215                 220

 tctagtcatc tcactgtgct tttgattttt gaaaatgcat cttttcctgt ggctattaaa    733

 ctatagtttc tttccaagac tggtaaacca tttttatctt ctagtctgag accaaaatca    793

 atcaagactg aatagtaatg acacccatta ctgtggatga gttttctcaa ttttaaaata    853

 gcgattgcac agaagtggta aataaaacat taatctctat gtatctttga aggtattatt    913

 catatggagc gg                                                        925




      <210> 18
      <211> 1172
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(759)

      <400> 18
 gcacgagccc gagctctact gactcccaaa agagcgccca agaagaaa atg gcc ata      57
                                                      Met Ala Ile
                                                        1

 agt gga gtc cct gtg cta gga ttt ttc atc ata gct gtg ctg atg agc      105
 Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val Leu Met Ser
       5                  10                  15

 gct cag gaa tca tgg gct atc aaa gaa gaa cat gtg atc atc cag gcc      153
 Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile Ile Gln Ala
  20                  25                  30                  35

 gag ttc tat ctg aat cct gac caa tca ggc gag ttt atg ttt gac ttt      201
 Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met Phe Asp Phe
                  40                  45                  50

 gat ggt gat gag att ttc cat gtg gat atg gca aag aag gag acg gtc      249
 Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys Glu Thr Val
              55                  60                  65

 tgg cgg ctt gaa gaa ttt gga cga ttt gcc agc ttt gag gct caa ggt      297
 Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu Ala Gln Gly
          70                  75                  80

 gca ttg gcc aac ata gct gtg gac aaa gcc aac ctg gaa atc atg aca      345
 Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu Ile Met Thr
      85                  90                  95

 aag cgc tcc aac tat act ccg atc acc aat gta cct cca gag gta act      393
 Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro Glu Val Thr
 100                 105                 110                 115

 gtg ctc acg aac agc cct gtg gaa ctg aga gag ccc aac gtc ctc atc      441
 Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn Val Leu Ile
                 120                 125                 130

 tgt ttc atc gac aag ttc acc cca cca gtg gtc aat gtc acg tgg ctt      489
 Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val Thr Trp Leu
             135                 140                 145

 cga aat ggc ctt ttc cgc aag ttc cac tat ctc ccc ttc ctg ccc tca      537
 Arg Asn Gly Leu Phe Arg Lys Phe His Tyr Leu Pro Phe Leu Pro Ser
         150                 155                 160

 act gag gac gtt tac gac tgc agg gtg gag cac tgg ggc ttg gat gag      585
 Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly Leu Asp Glu
     165                 170                 175

 cct ctt ctc aag cac tgg gag ttt gat gct cca agc cct ctc cca gag      633
 Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro Leu Pro Glu
 180                 185                 190                 195

 act aca gag aac gtg gtg tgt gcc ctg ggc ctg act gtg ggt ctg gtg      681
 Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu Thr Val Gly Leu Val
                 200                 205                 210

 ggc atc att att ggg acc atc ttc atc atc aag gga gtg cgc aaa agc      729
 Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys Gly Val Arg Lys Ser
             215                 220                 225

 aat gca gca gaa cgc agg ggg cct ctg taa g gcacatggag gtgatggtgt      780
 Asn Ala Ala Glu Arg Arg Gly Pro Leu 
         230                 235

 ttcttagaga gaagatctct gaagaaactt ctgctttaat gactttacaa agctggcaat    840

 attacaatcc ttgacctcag tgaaagcagt catcttcagc gttttccagc cctatagcca    900

 ccccaagtgt ggttatgcct cctcgattgc tccgtactct aacatctagc tgggttccct    960

 gtctattgcc ctttcctgta tctattttcc tctatttcct atccttttat tatccccctg   1020

 caatgccttt ggaataaaac aaacaggagt ctgtttttgc tatggaatgc cccctggggc   1080

 attttttgtg gacttattgt ttaaggtttc ccccaactgt gatttttttg aaccccataa   1140

 actattttta tgattttggg tggaaaaaaa aa                                 1172




      <210> 19
      <211> 2014
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (141)..(1739)

      <400> 19
 tcttcagagt cacgggtcca cccacgcgtc cgtgtaaacg aaaagcttca taagtccctc     60

 tttgcttagt acttttctcg tcctttcccc agggtgcacg taaccctcaa gcactaggac    120

 cgtgcggaat ccaggctgcg    atg gca cct tca ttt acc gcc cgc att cag     170
                          Met Ala Pro Ser Phe Thr Ala Arg Ile Gln
                            1               5                  10

 ttg ttc ctc ttg cgg gcg cta ggc ttt ctc ata ggc tta gta ggc cga      218
 Leu Phe Leu Leu Arg Ala Leu Gly Phe Leu Ile Gly Leu Val Gly Arg
                  15                  20                  25

 gca gct tta gtc tta ggg ggt cca aag ttt gcc tca aag acc cct cgg      266
 Ala Ala Leu Val Leu Gly Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg
              30                  35                  40

 ccg gtg act gaa cca ttg ctt ctg ctt tcg ggg atg cag ctg gcc aag      314
 Pro Val Thr Glu Pro Leu Leu Leu Leu Ser Gly Met Gln Leu Ala Lys
          45                  50                  55

 ctg atc cga cag aga aag gtg aaa tgt ata gat gtt gtt cag gct tat      362
 Leu Ile Arg Gln Arg Lys Val Lys Cys Ile Asp Val Val Gln Ala Tyr
      60                  65                  70

 atc aac aga atc aag gac gtg aac cca atg atc aat gga att gtc aag      410
 Ile Asn Arg Ile Lys Asp Val Asn Pro Met Ile Asn Gly Ile Val Lys
  75                  80                  85                  90

 tac agg ttt gag gaa gcg atg aag gag gct cat gct gta gat caa aag      458
 Tyr Arg Phe Glu Glu Ala Met Lys Glu Ala His Ala Val Asp Gln Lys
                  95                 100                 105

 ctt gca gag aag cag gaa gat gaa gcc acc ctg gaa aat aaa tgg ccc      506
 Leu Ala Glu Lys Gln Glu Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro
             110                 115                 120

 ttc ctt ggg gtt cct ttg aca gtc aag gaa gct ttc cag cta caa gga      554
 Phe Leu Gly Val Pro Leu Thr Val Lys Glu Ala Phe Gln Leu Gln Gly
         125                 130                 135

 atg ccc aat tct tct gga ctc atg aac cgt cgt gat gcc att gcc aaa      602
 Met Pro Asn Ser Ser Gly Leu Met Asn Arg Arg Asp Ala Ile Ala Lys
     140                 145                 150

 aca gat gcc act gtg ggg gca tta ctg aag gga gct ggt gcc att cct      650
 Thr Asp Ala Thr Val Gly Ala Leu Leu Lys Gly Ala Gly Ala Ile Pro
 155                 160                 165                 170

 ctt ggc ata acc aac tgt agt gag ttg tgt atg tgg tat gaa tcc agt      698
 Leu Gly Ile Thr Asn Cys Ser Glu Leu Cys Met Trp Tyr Glu Ser Ser
                 175                 180                 185

 aac aag atc tat ggc cga tca aac aac cca tat gat tta cag cat att      746
 Asn Lys Ile Tyr Gly Arg Ser Asn Asn Pro Tyr Asp Leu Gln His Ile
             190                 195                 200

 gta ggt gga agt tct ggt ggt gag ggc tgc aca ctg gca gct gcc tgc      794
 Val Gly Gly Ser Ser Gly Gly Glu Gly Cys Thr Leu Ala Ala Ala Cys
         205                 210                 215

 tca gtt att ggt gtg ggc tct gat att ggt ggt agc att cga atg cct      842
 Ser Val Ile Gly Val Gly Ser Asp Ile Gly Gly Ser Ile Arg Met Pro
     220                 225                 230

 gct ttc ttc aat ggt ata ttt gga cac aag cct tct cca ggt gtg gtt      890
 Ala Phe Phe Asn Gly Ile Phe Gly His Lys Pro Ser Pro Gly Val Val
 235                 240                 245                 250

 ccc aac aaa ggt cag ttt ccc ttg gct gtg gga gcc cag gag ttg ttt      938
 Pro Asn Lys Gly Gln Phe Pro Leu Ala Val Gly Ala Gln Glu Leu Phe
                 255                 260                 265

 ctg tgc act ggt cct atg tgc cgc tat gct gaa gac ctg gcc ccc atg      986
 Leu Cys Thr Gly Pro Met Cys Arg Tyr Ala Glu Asp Leu Ala Pro Met
             270                 275                 280

 ttg aag gtc atg gca gga cct ggg atc aaa agg tta aaa cta gac aca     1034
 Leu Lys Val Met Ala Gly Pro Gly Ile Lys Arg Leu Lys Leu Asp Thr
         285                 290                 295

 aag gta cat tta aaa gac tta aaa ttt tac tgg atg gaa cat gat gga     1082
 Lys Val His Leu Lys Asp Leu Lys Phe Tyr Trp Met Glu His Asp Gly
     300                 305                 310

 ggc tca ttt tta atg tcc aaa gtg gac caa gat ctc att atg act cag     1130
 Gly Ser Phe Leu Met Ser Lys Val Asp Gln Asp Leu Ile Met Thr Gln
 315                 320                 325                 330

 aaa aag gtt gcg gtt cac ctt gaa act att cta gga gcc tca gtt caa     1178
 Lys Lys Val Ala Val His Leu Glu Thr Ile Leu Gly Ala Ser Val Gln
                 335                 340                 345

 cat gtt aaa ctg aag aaa atg aag tac tct ttt cag ttg tgg atc gca     1226
 His Val Lys Leu Lys Lys Met Lys Tyr Ser Phe Gln Leu Trp Ile Ala
             350                 355                 360

 atg atg tca gca aag gga cat gat ggg aag gaa cct gtg aaa ttt gta     1274
 Met Met Ser Ala Lys Gly His Asp Gly Lys Glu Pro Val Lys Phe Val
         365                 370                 375

 gat ttg ctt ggt gac cat ggg aaa cat gtc agt cct ctg tgg gag ttg     1322
 Asp Leu Leu Gly Asp His Gly Lys His Val Ser Pro Leu Trp Glu Leu
     380                 385                 390

 atc aaa tgg tgc ctg ggt ctg tca gtg tac acc atc cct tcc att gga     1370
 Ile Lys Trp Cys Leu Gly Leu Ser Val Tyr Thr Ile Pro Ser Ile Gly
 395                 400                 405                 410

 ctg gct ttg ttg gaa gaa aag ctc aga tat agc aat gag aaa tac caa     1418
 Leu Ala Leu Leu Glu Glu Lys Leu Arg Tyr Ser Asn Glu Lys Tyr Gln
                 415                 420                 425

 aag ttt aag gca gtg gaa gaa agc ctg cgt aaa gag ctg gtg gat atg     1466
 Lys Phe Lys Ala Val Glu Glu Ser Leu Arg Lys Glu Leu Val Asp Met
             430                 435                 440

 cta ggt gat gat ggt gtg ttc tta tat ccc tca cat ccc aca gtg gca     1514
 Leu Gly Asp Asp Gly Val Phe Leu Tyr Pro Ser His Pro Thr Val Ala
         445                 450                 455

 cct aag cat cat gtc cct cta aca cgg cct ttc aac ttt gct tac aca     1562
 Pro Lys His His Val Pro Leu Thr Arg Pro Phe Asn Phe Ala Tyr Thr
     460                 465                 470

 ggt gtc ttc agt gcc ctg ggt ttg cct gtg acc caa tgc cca ctg gga     1610
 Gly Val Phe Ser Ala Leu Gly Leu Pro Val Thr Gln Cys Pro Leu Gly
 475                 480                 485                 490

 ctg aat gcc aaa gga ctc cct tta ggc atc cag gtt gtg gct gga ccc     1658
 Leu Asn Ala Lys Gly Leu Pro Leu Gly Ile Gln Val Val Ala Gly Pro
                 495                 500                 505

 ttt aat gat cat ctg acc ctg gct gtg gcc cag tac ttg gag aaa act     1706
 Phe Asn Asp His Leu Thr Leu Ala Val Ala Gln Tyr Leu Glu Lys Thr
             510                 515                 520

 ttt ggg ggc tgg gtc tgt cca gga aag ttt tag gaggacct tctgcaaggt     1757
 Phe Gly Gly Trp Val Cys Pro Gly Lys Phe 
         525                 530

 taatgtgtgt gtgtgtttgt gttcgtgtgg tggtgtttct attaattggg tgaaaccaag   1817

 caccagcaga caagcagaga aacaactggg gaatttattg actcatttag ttattctttc   1877

 tacttttatt tccttctcta actgttggtc ttactaaaat ggtaatattt gcttcttgct   1937

 tttatgttac tggaaaatta ggacatgtaa atggataagt gcaataaagt ttcctaaatg   1997

 ctaaaaaaaa aaaaaaa                                                  2014




      <210> 20
      <211> 2913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (130)..(1917)

      <400> 20
 cttcttagaa ggcatgatcc caaacatggg taacattaaa ctaggtagca aagctgttac     60

 cgacagaggc aatgcttctg tgagccaaaa tgtggcgacc acaaagagtg tgtaggcaca    120

 ttctgcttc    atg aaa ttc ttc agt tac att ctg gtt tat cgc cga ttt     168
              Met Lys Phe Phe Ser Tyr Ile Leu Val Tyr Arg Arg Phe
                1               5                  10

 ctc ttc gtg gtt ttc act gtg ttg gtt tta cta cct ctg ccc atc gtc      216
 Leu Phe Val Val Phe Thr Val Leu Val Leu Leu Pro Leu Pro Ile Val
      15                  20                  25

 ctc cac acc aag gaa gca gaa tgt gcc tac aca ctc ttt gtg gtc gcc      264
 Leu His Thr Lys Glu Ala Glu Cys Ala Tyr Thr Leu Phe Val Val Ala
  30                  35                  40                  45

 aca ttt tgg ctc aca gaa gca ttg cct ctg tcg gta aca gct ttg cta      312
 Thr Phe Trp Leu Thr Glu Ala Leu Pro Leu Ser Val Thr Ala Leu Leu
                  50                  55                  60

 cct agt tta atg tta ccc atg ttt ggg atc atg cct tct aag aag gtg      360
 Pro Ser Leu Met Leu Pro Met Phe Gly Ile Met Pro Ser Lys Lys Val
              65                  70                  75

 gca tct gct tat ttc aag gat ttt cac tta ctg cta att gga gtt atc      408
 Ala Ser Ala Tyr Phe Lys Asp Phe His Leu Leu Leu Ile Gly Val Ile
          80                  85                  90

 tgt tta gca aca tcc ata gaa aaa tgg aat ttg cac aag aga att gct      456
 Cys Leu Ala Thr Ser Ile Glu Lys Trp Asn Leu His Lys Arg Ile Ala
      95                 100                 105

 ctg aaa atg gtg atg atg gtt ggt gta aat cct gca tgg ctg acg ctg      504
 Leu Lys Met Val Met Met Val Gly Val Asn Pro Ala Trp Leu Thr Leu
 110                 115                 120                 125

 ggg ttc atg agc agc act gcc ttt ttg tct atg tgg ctc agc aac acc      552
 Gly Phe Met Ser Ser Thr Ala Phe Leu Ser Met Trp Leu Ser Asn Thr
                 130                 135                 140

 tcg acg gct gcc atg gtg atg ccc att gcg gag gct gta gtg cag cag      600
 Ser Thr Ala Ala Met Val Met Pro Ile Ala Glu Ala Val Val Gln Gln
             145                 150                 155

 atc atc aat gca gaa gca gag gtc gag gcc act cag atg act tac ttc      648
 Ile Ile Asn Ala Glu Ala Glu Val Glu Ala Thr Gln Met Thr Tyr Phe
         160                 165                 170

 aac gga tca acc aac cac gga cta gaa att gat gaa agt gtt aat gga      696
 Asn Gly Ser Thr Asn His Gly Leu Glu Ile Asp Glu Ser Val Asn Gly
     175                 180                 185

 cat gaa ata aat gag agg aaa gag aaa aca aaa cca gtt cca gga tac      744
 His Glu Ile Asn Glu Arg Lys Glu Lys Thr Lys Pro Val Pro Gly Tyr
 190                 195                 200                 205

 aat aat gat aca ggg aaa att tca agc aag gtg gag ttg gaa aag aac      792
 Asn Asn Asp Thr Gly Lys Ile Ser Ser Lys Val Glu Leu Glu Lys Asn
                 210                 215                 220

 tca ggc atg aga acc aaa tat cga aca aag aag ggc cac gtg aca cgt      840
 Ser Gly Met Arg Thr Lys Tyr Arg Thr Lys Lys Gly His Val Thr Arg
             225                 230                 235

 aaa ctt acg tgt ttg tgc att gcc tac tct tct acc att ggt gga ctg      888
 Lys Leu Thr Cys Leu Cys Ile Ala Tyr Ser Ser Thr Ile Gly Gly Leu
         240                 245                 250

 aca aca atc act ggt acc tcc acc aac ttg atc ttt gca gag tat ttc      936
 Thr Thr Ile Thr Gly Thr Ser Thr Asn Leu Ile Phe Ala Glu Tyr Phe
     255                 260                 265

 aat aca cgc tat cct gac tgt cgt tgc ctc aac ttt gga tca tgg ttt      984
 Asn Thr Arg Tyr Pro Asp Cys Arg Cys Leu Asn Phe Gly Ser Trp Phe
 270                 275                 280                 285

 acg ttt tcc ttc cca gct gcc ctt atc att cta ctc tta tcc tgg atc     1032
 Thr Phe Ser Phe Pro Ala Ala Leu Ile Ile Leu Leu Leu Ser Trp Ile
                 290                 295                 300

 tgg ctt cag tgg ctt ttc cta gga ttc aat ttt aag gag atg ttc aaa     1080
 Trp Leu Gln Trp Leu Phe Leu Gly Phe Asn Phe Lys Glu Met Phe Lys
             305                 310                 315

 tgt ggc aaa acc aaa aca gtc caa caa aaa gct tgt gct gag gtg att     1128
 Cys Gly Lys Thr Lys Thr Val Gln Gln Lys Ala Cys Ala Glu Val Ile
         320                 325                 330

 aag caa gaa tac caa aag ctt ggg cca ata agg tat caa gaa att gtg     1176
 Lys Gln Glu Tyr Gln Lys Leu Gly Pro Ile Arg Tyr Gln Glu Ile Val
     335                 340                 345

 acc ttg gtc ctc ttc att ata atg gct ctg cta tgg ttt agt cga gac     1224
 Thr Leu Val Leu Phe Ile Ile Met Ala Leu Leu Trp Phe Ser Arg Asp
 350                 355                 360                 365

 ccc gga ttt gtt cct ggt tgg tct gca ctt ttt tca gag tac cct ggt     1272
 Pro Gly Phe Val Pro Gly Trp Ser Ala Leu Phe Ser Glu Tyr Pro Gly
                 370                 375                 380

 ttt gct aca gat tca act gtt gct tta ctt ata ggg ctg cta ttc ttt     1320
 Phe Ala Thr Asp Ser Thr Val Ala Leu Leu Ile Gly Leu Leu Phe Phe
             385                 390                 395

 ctt atc cca gct aag aca ctg act aaa act aca cct aca gga gaa att     1368
 Leu Ile Pro Ala Lys Thr Leu Thr Lys Thr Thr Pro Thr Gly Glu Ile
         400                 405                 410

 gtt gct ttt gat tac tct cca ctg att act tgg aaa gaa ttc cag tca     1416
 Val Ala Phe Asp Tyr Ser Pro Leu Ile Thr Trp Lys Glu Phe Gln Ser
     415                 420                 425

 ttc atg ccc tgg gat ata gcc att ctt gtt ggt gga ggg ttt gcc ctg     1464
 Phe Met Pro Trp Asp Ile Ala Ile Leu Val Gly Gly Gly Phe Ala Leu
 430                 435                 440                 445

 gca gat ggt tgt gag gag tct gga tta tct aag tgg ata gga aat aaa     1512
 Ala Asp Gly Cys Glu Glu Ser Gly Leu Ser Lys Trp Ile Gly Asn Lys
                 450                 455                 460

 tta tct cct ctg ggt tca tta cca gca tgg cta ata att ctg ata tct     1560
 Leu Ser Pro Leu Gly Ser Leu Pro Ala Trp Leu Ile Ile Leu Ile Ser
             465                 470                 475

 tct ttg atg gtg aca tct tta act gag gta gcc agc aat cca gct acc     1608
 Ser Leu Met Val Thr Ser Leu Thr Glu Val Ala Ser Asn Pro Ala Thr
         480                 485                 490

 att aca ctc ttt ctc cca ata tta tct cca ttg gcc gaa gcc att cat     1656
 Ile Thr Leu Phe Leu Pro Ile Leu Ser Pro Leu Ala Glu Ala Ile His
     495                 500                 505

 gtg aac cct ctt tat att ctg ata cct tct act ctg tgt act tca ttt     1704
 Val Asn Pro Leu Tyr Ile Leu Ile Pro Ser Thr Leu Cys Thr Ser Phe
 510                 515                 520                 525

 gca ttc ctc cta cca gta gca aat cca ccc aat gct att gtc ttt tca     1752
 Ala Phe Leu Leu Pro Val Ala Asn Pro Pro Asn Ala Ile Val Phe Ser
                 530                 535                 540

 tat ggt cat ctg aaa gtc att gac atg gtt aaa gct gga ctt ggt gtc     1800
 Tyr Gly His Leu Lys Val Ile Asp Met Val Lys Ala Gly Leu Gly Val
             545                 550                 555

 aac att gtt ggt gtt gct gtg gtt atg ctt ggc ata tgt act tgg att     1848
 Asn Ile Val Gly Val Ala Val Val Met Leu Gly Ile Cys Thr Trp Ile
         560                 565                 570

 gta ccc atg ttt gac ctc tac act tac cct tcg tgg gct cct gct atg     1896
 Val Pro Met Phe Asp Leu Tyr Thr Tyr Pro Ser Trp Ala Pro Ala Met
     575                 580                 585

 agt aat gag acc atg cca taa ta agcacaaaat ttctgactat cttgcggtaa     1949
 Ser Asn Glu Thr Met Pro 
 590                 595

 tttctggaag acattaatga ttgactgtaa aatgtggctc taaataacta atgacacaca   2009

 tttaaatcag ttatggtgta gctgctgcaa ttcccgtgaa tacccgaaac ctgctgttat   2069

 aactcagagt ccatatttgt tattgcagtg caactaaaga gcatctatgt gccttcatca   2129

 agaagcccat gttttgagat tttgctcatg aaccatctgc aacttgcttc atcataagaa   2189

 taatttataa cttgaccttc aaagagatta gagcatttgt ttcatcttac agttggagtt   2249

 caatgtaaca ttttaaatgc aatttattat ttcagaaatt tcccatgaaa ctaaaaatag   2309

 aaaataagat atacaagtta attcggtact tggataaatc atttctgcat tgttgttcca   2369

 gagaatttgc tgagaaatca aagccatggt catctggtga tgaagagaaa agtttaatct   2429

 aaatgatatg tgcatttcct catttaaaaa atccaattgg attattctta atatatacat   2489

 gtaatatgaa aattgagatt gaagcactaa ttccaaaatt atggctgaat atactaaata   2549

 acagaaaagt tacagataag aatttatttc tactgaactc tatagttagt gtaatataat   2609

 tcatattttt atgatattgg cacactgaga aattcatttt gtagagctat ggataaggct   2669

 tgctatgatt tgcactatta gtacagtata gttagaaagg aaagctgaac actataaaac   2729

 tattaacata ttttcgtata tgagtaacaa ctttgcttaa gtgtttatct tagttcagaa   2789

 atacataatg tcatatgtta aaaataaaga gatgtagaaa tctaaatgaa ttatcactgt   2849

 gtatacagac agaaaaatca cataactctg gtgtgttaac attgcaatga aaaaatgaaa   2909

 aaaa                                                                2913




      <210> 21
      <211> 1421
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (182)..(1090)

      <400> 21
 ggcttgagga gaagcgccaa gtgcgcatgg ggacgctata gcaattcgtt tgctgtcctt     60

 cctctccttc gaagatgaca aggcctacca tcgtttcttc ctgcctttgg gccgtcaggc    120

 agttggttgg gacccgctcc aaccctcggt tcttcctgca atacagtgga tacaatttgt    180

 c    atg gct act ctg agt gtt ata ggt tca agt tca ctt att gcc tat     226
      Met Ala Thr Leu Ser Val Ile Gly Ser Ser Ser Leu Ile Ala Tyr
        1               5                  10                  15

 gct gta ttc cat aat ata cag aaa tct cca gag ata aga cca ctt ttt      274
 Ala Val Phe His Asn Ile Gln Lys Ser Pro Glu Ile Arg Pro Leu Phe
                  20                  25                  30

 tat ctg agc ttc tgt gac ctg ctc ctg gga ctt tgc tgg ctc acg gag      322
 Tyr Leu Ser Phe Cys Asp Leu Leu Leu Gly Leu Cys Trp Leu Thr Glu
              35                  40                  45

 aca ctt ctc tat gga gct tca gta gca aat aag gac atc atc tgc tat      370
 Thr Leu Leu Tyr Gly Ala Ser Val Ala Asn Lys Asp Ile Ile Cys Tyr
          50                  55                  60

 aac cta caa gca gtt gga cag gtg ata gat tat act tgt cga gtt ggt      418
 Asn Leu Gln Ala Val Gly Gln Val Ile Asp Tyr Thr Cys Arg Val Gly
      65                  70                  75

 caa atg gcc ttt gtt ttc tca agc ctg ata cct ctg cta ttg atg aca      466
 Gln Met Ala Phe Val Phe Ser Ser Leu Ile Pro Leu Leu Leu Met Thr
  80                  85                  90                  95

 cct gta ttc tgt ctg gga aat act agt gaa tgt ttc caa aac ttc agt      514
 Pro Val Phe Cys Leu Gly Asn Thr Ser Glu Cys Phe Gln Asn Phe Ser
                 100                 105                 110

 cag agc cac aag tgt atc ttg atg cac tca cca cca tca gcc atg gct      562
 Gln Ser His Lys Cys Ile Leu Met His Ser Pro Pro Ser Ala Met Ala
             115                 120                 125

 gaa ctt cca cct tct gcc aac aca tct gtc tgt agc aca ctt tat ttt      610
 Glu Leu Pro Pro Ser Ala Asn Thr Ser Val Cys Ser Thr Leu Tyr Phe
         130                 135                 140

 tat ggt atc gcc att ttc ctg ggc agc ttt gta ctc agc ctc ctt acc      658
 Tyr Gly Ile Ala Ile Phe Leu Gly Ser Phe Val Leu Ser Leu Leu Thr
     145                 150                 155

 att atg gtc tta ctt atc cga gcc cag aca ttg tat aag aag ttt gtg      706
 Ile Met Val Leu Leu Ile Arg Ala Gln Thr Leu Tyr Lys Lys Phe Val
 160                 165                 170                 175

 aag tca act ggc ttt ctg ggg agt gaa cag tgg gca gtg att cac att      754
 Lys Ser Thr Gly Phe Leu Gly Ser Glu Gln Trp Ala Val Ile His Ile
                 180                 185                 190

 gtg gac caa cgg gtg cgc ttc tac cca gtg gcc ttc ttt tgc tgc tgg      802
 Val Asp Gln Arg Val Arg Phe Tyr Pro Val Ala Phe Phe Cys Cys Trp
             195                 200                 205

 ggc cca gct gtc att cta atg atc ata aag ctg act aag cca cag gac      850
 Gly Pro Ala Val Ile Leu Met Ile Ile Lys Leu Thr Lys Pro Gln Asp
         210                 215                 220

 acc aag ctt cac atg gcc ctt tat gtt ctc cag gct cta acg gca aca      898
 Thr Lys Leu His Met Ala Leu Tyr Val Leu Gln Ala Leu Thr Ala Thr
     225                 230                 235

 tct cag ggt cta ctc aac tgt gga gta tat ggc tgg acg cag cac aaa      946
 Ser Gln Gly Leu Leu Asn Cys Gly Val Tyr Gly Trp Thr Gln His Lys
 240                 245                 250                 255

 ttc cac caa cta aag cag gag gct cgg cgt gat gca gat acc cag aca      994
 Phe His Gln Leu Lys Gln Glu Ala Arg Arg Asp Ala Asp Thr Gln Thr
                 260                 265                 270

 cca tta tta tgc tca cag aag aga ttc tat agc agg ggc tta aat tca     1042
 Pro Leu Leu Cys Ser Gln Lys Arg Phe Tyr Ser Arg Gly Leu Asn Ser
             275                 280                 285

 ctg gaa tcc acc ctg act ttt cct gcc agt act tct acc att ttt tga     1090
 Leu Glu Ser Thr Leu Thr Phe Pro Ala Ser Thr Ser Thr Ile Phe 
         290                 295                 300

 aactacaata ctggaacatc caggaactgg agttattcta cgctaatgga ttggaaagaa   1150

 tgttgggaaa ggacatctta aatcttttct aactatgccc taaactgcag aactcaaagg   1210

 aaatatagtg ccattgttag tagtcattct agatgaattg ggagtatctc tccagttatt   1270

 cccagattca ctagtgatcc ttaaagtctc tattcaggga gaggaagaca ctttccatct   1330

 cagagataga ctcgtgttac cttgatggat attggatttg tctaagtctc ttctagaaaa   1390

 aataaattct agattattat ttaaaaaaaa a                                  1421




      <210> 22
      <211> 3323
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (299)..(2410)

      <400> 22
 cgcccgggca ggtcagcctg tctcaaggca cgccagtctc agctccgacc ttgcagcggc     60

 gcagcgcggg tgggaggcgg ggaggagcag cgggaagagc ggagcgagga cccggtccgg    120

 cgcagtcttc aatgagcagc gcggaaactg caccccagac ccgagcctgc tgcgcgcccc    180

 ctcccagagc tcacctggtg ccaggtaaca ggcctggcct cgccctgtgg atgatgatgg    240

 ccttgccccc gtgagctaca acctggcctt cagcacccgc ccacctccaa ccagcagg      298                                                                 
 atg cgg ctg tgg aag gcg gtg gtg gtg act ttg gcc ttc atg agt gtg      346
 Met Arg Leu Trp Lys Ala Val Val Val Thr Leu Ala Phe Met Ser Val
   1               5                  10                  15

 gac atc tgc gtg acc acg gcc atc tat gtc ttc agc cac ctg gac cgc      394
 Asp Ile Cys Val Thr Thr Ala Ile Tyr Val Phe Ser His Leu Asp Arg
              20                  25                  30

 agc ctc ctg gag gac atc cgc cac ttc aac atc ttt gac tcg gtg ctg      442
 Ser Leu Leu Glu Asp Ile Arg His Phe Asn Ile Phe Asp Ser Val Leu
          35                  40                  45

 gat ctc tgg gca gcc tgc ctg tac cgc agc tgc ctg ctg ctg gga gcc      490
 Asp Leu Trp Ala Ala Cys Leu Tyr Arg Ser Cys Leu Leu Leu Gly Ala
      50                  55                  60

 acc att ggt gtg gcc aag aac agt gcg ctg ggg ccc cgg cgg ctg cgg      538
 Thr Ile Gly Val Ala Lys Asn Ser Ala Leu Gly Pro Arg Arg Leu Arg
  65                  70                  75                  80

 gcc tcg tgg ctg gtc atc acc ctc gtg tgc ctc ttc gtg ggc atc tat      586
 Ala Ser Trp Leu Val Ile Thr Leu Val Cys Leu Phe Val Gly Ile Tyr
                  85                  90                  95

 gcc atg gtg aag ctg ctg ctc ttc tca gag gtg cgc agg ccc atc cgg      634
 Ala Met Val Lys Leu Leu Leu Phe Ser Glu Val Arg Arg Pro Ile Arg
             100                 105                 110

 gac ccc tgg ttt tgg gcc ctg ttc gtg tgg acg tac att tca ctc ggc      682
 Asp Pro Trp Phe Trp Ala Leu Phe Val Trp Thr Tyr Ile Ser Leu Gly
         115                 120                 125

 gca tcc ttc ctg ctc tgg tgg ctg ctg tcc acc gtg cgg cca ggc acc      730
 Ala Ser Phe Leu Leu Trp Trp Leu Leu Ser Thr Val Arg Pro Gly Thr
     130                 135                 140

 cag gcc ctg gag cca ggg gcg gcc acc gag gct gag ggc ttc cct ggg      778
 Gln Ala Leu Glu Pro Gly Ala Ala Thr Glu Ala Glu Gly Phe Pro Gly
 145                 150                 155                 160

 agc ggc cgg cca ccg ccc gag cag gcg tct ggg gcc acg ctg cag aag      826
 Ser Gly Arg Pro Pro Pro Glu Gln Ala Ser Gly Ala Thr Leu Gln Lys
                 165                 170                 175

 ctg ctc tcc tac acc aag ccc gac gtg gcc ttc ctc gtg gcc gcc tcc      874
 Leu Leu Ser Tyr Thr Lys Pro Asp Val Ala Phe Leu Val Ala Ala Ser
             180                 185                 190

 ttc ttc ctc atc gtg gca gct ctg gga gag acc ttc ctg ccc tac tac      922
 Phe Phe Leu Ile Val Ala Ala Leu Gly Glu Thr Phe Leu Pro Tyr Tyr
         195                 200                 205

 acg ggc cgc gcc att gat ggc atc gtc atc cag aaa agc atg gat cag      970
 Thr Gly Arg Ala Ile Asp Gly Ile Val Ile Gln Lys Ser Met Asp Gln
     210                 215                 220

 ttc agc acg gct gtc gtc atc gtg tgc ctg ctg gcc att ggc agc tca     1018
 Phe Ser Thr Ala Val Val Ile Val Cys Leu Leu Ala Ile Gly Ser Ser
 225                 230                 235                 240

 ttt gcc gca ggt att cgg ggc ggc att ttt acc ctc ata ttt gcc aga     1066
 Phe Ala Ala Gly Ile Arg Gly Gly Ile Phe Thr Leu Ile Phe Ala Arg
                 245                 250                 255

 ctg aac att cgc ctt cga aac tgt ctc ttc cgc tca ctg gtg tcc cag     1114
 Leu Asn Ile Arg Leu Arg Asn Cys Leu Phe Arg Ser Leu Val Ser Gln
             260                 265                 270

 gag aca agc ttc ttt gat gag aac cgc aca ggg gac ctc atc tcc cgc     1162
 Glu Thr Ser Phe Phe Asp Glu Asn Arg Thr Gly Asp Leu Ile Ser Arg
         275                 280                 285

 ctg acc tcg gac acc acc atg gtc agc gac ctg gtc tcc cag aac atc     1210
 Leu Thr Ser Asp Thr Thr Met Val Ser Asp Leu Val Ser Gln Asn Ile
     290                 295                 300

 aat gtc ttc ctg cgg aac aca gtc aag gtc acg ggc gtg gtg gtc ttc     1258
 Asn Val Phe Leu Arg Asn Thr Val Lys Val Thr Gly Val Val Val Phe
 305                 310                 315                 320

 atg ttc agc ctc tca tgg cag ctc tcc ttg gtc acc ttc atg ggc ttc     1306
 Met Phe Ser Leu Ser Trp Gln Leu Ser Leu Val Thr Phe Met Gly Phe
                 325                 330                 335

 ccc atc atc atg atg gtg tcc aac atc tac ggc aag tac tac aag agg     1354
 Pro Ile Ile Met Met Val Ser Asn Ile Tyr Gly Lys Tyr Tyr Lys Arg
             340                 345                 350

 ctc tcc aaa gag gtc cag aat gcc ctg gcc aga gcg agc aac acg gcg     1402
 Leu Ser Lys Glu Val Gln Asn Ala Leu Ala Arg Ala Ser Asn Thr Ala
         355                 360                 365

 gag gag acc atc agt gcc atg aag act gtc cgg agc ttc gcc aat gag     1450
 Glu Glu Thr Ile Ser Ala Met Lys Thr Val Arg Ser Phe Ala Asn Glu
     370                 375                 380

 gag gag gag gca gag gtg tac ctg cgg aag ctg cag cag gtg tac aag     1498
 Glu Glu Glu Ala Glu Val Tyr Leu Arg Lys Leu Gln Gln Val Tyr Lys
 385                 390                 395                 400

 ctg aac agg aag gag gca gct gcc tac atg tac tac gtc tgg ggc agc     1546
 Leu Asn Arg Lys Glu Ala Ala Ala Tyr Met Tyr Tyr Val Trp Gly Ser
                 405                 410                 415

 ggg ctc aca ctg ctg gtg gtc cag gtc agc atc ctc tac tac ggg ggc     1594
 Gly Leu Thr Leu Leu Val Val Gln Val Ser Ile Leu Tyr Tyr Gly Gly
             420                 425                 430

 cac ctt gtc atc tca ggc cag atg acc agc ggc aac ctc atc gcc ttc     1642
 His Leu Val Ile Ser Gly Gln Met Thr Ser Gly Asn Leu Ile Ala Phe
         435                 440                 445

 atc atc tac gag ttt gtc ctg gga gat tgt atg gag aat gtc tcc ttc     1690
 Ile Ile Tyr Glu Phe Val Leu Gly Asp Cys Met Glu Asn Val Ser Phe
     450                 455                 460

 agc ctg tcc ccc ggc aag gtg acg gcc ctg gtg ggg ccc tcg ggc agt     1738
 Ser Leu Ser Pro Gly Lys Val Thr Ala Leu Val Gly Pro Ser Gly Ser
 465                 470                 475                 480

 ggg aag agc tcc tgt gtc aac atc ctg gag aac ttc tac ccc ctg gag     1786
 Gly Lys Ser Ser Cys Val Asn Ile Leu Glu Asn Phe Tyr Pro Leu Glu
                 485                 490                 495

 ggg ggc cgg gtg ctg ctg gac ggc aag ccc atc agc gcc tac gac cac     1834
 Gly Gly Arg Val Leu Leu Asp Gly Lys Pro Ile Ser Ala Tyr Asp His
             500                 505                 510

 aag tac ttg cac cgt gtg atc tcc ctg gtg agc cag gag ccc gtg ctg     1882
 Lys Tyr Leu His Arg Val Ile Ser Leu Val Ser Gln Glu Pro Val Leu
         515                 520                 525

 ttc gcc cgc tcc atc acg gat aac atc tcc tac ggc ctg ccc act gtg     1930
 Phe Ala Arg Ser Ile Thr Asp Asn Ile Ser Tyr Gly Leu Pro Thr Val
     530                 535                 540

 cct ttc gag atg gtg gtg gag gcc gca cag aag gcc aat gcc cac ggc     1978
 Pro Phe Glu Met Val Val Glu Ala Ala Gln Lys Ala Asn Ala His Gly
 545                 550                 555                 560

 ttc atc atg gaa ctc cag gac ggc tac agc aca gag aca ggg gag aag     2026
 Phe Ile Met Glu Leu Gln Asp Gly Tyr Ser Thr Glu Thr Gly Glu Lys
                 565                 570                 575

 ggc gcc cag ctg tca ggt ggc cag aag cag cgg gtg gcc atg gcc cgg     2074
 Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Met Ala Arg
             580                 585                 590

 gct ctg gtg cgg aac ccc cca gtc ctc atc ctg gat gaa gcc acc agc     2122
 Ala Leu Val Arg Asn Pro Pro Val Leu Ile Leu Asp Glu Ala Thr Ser
         595                 600                 605

 gct ttg gat gcc gag agc gag tat ctg atc cag cag gcc atc cat ggc     2170
 Ala Leu Asp Ala Glu Ser Glu Tyr Leu Ile Gln Gln Ala Ile His Gly
     610                 615                 620

 aac ctg cag aag cac acg gta ctc atc atc gcg cac cgg ctg agc acc     2218
 Asn Leu Gln Lys His Thr Val Leu Ile Ile Ala His Arg Leu Ser Thr
 625                 630                 635                 640

 gtg gag cac gcg cac ctc att gtg gtg ctg gac aag ggc cgc gta gtg     2266
 Val Glu His Ala His Leu Ile Val Val Leu Asp Lys Gly Arg Val Val
                 645                 650                 655

 cag cag ggc acc cac cag cag ctg ctg gcc cag ggc ggc ctc tac gcc     2314
 Gln Gln Gly Thr His Gln Gln Leu Leu Ala Gln Gly Gly Leu Tyr Ala
             660                 665                 670

 aag ctg gtg cag cgg cag atg ctg ggg ctt cag ccc gcc gca gac ttc     2362
 Lys Leu Val Gln Arg Gln Met Leu Gly Leu Gln Pro Ala Ala Asp Phe
         675                 680                 685

 aca gct ggc cac aac gag cct gta gcc aac ggc agt cac aag gcc tga     2410
 Thr Ala Gly His Asn Glu Pro Val Ala Asn Gly Ser His Lys Ala 
     690                 695                 700

 tggggggccc ctgcttctcc cggtggggca gaggacccgg tgcctgcctg gcagatgtgc   2470

 ccacggaggc ccccagctgc cctccgagcc caggcctgca gcactgaaag acgacctgcc   2530

 atgtcccatg gatcaccgct tcctgcatct tgcccctggt ccctgcccca ttcccagggc   2590

 actccttacc cctgctgccc tgagccaacg ccttcacgga cctccctagc ctcctaagca   2650

 aaggtagagc tgccttttta aacctaggtc ttaccagggt ttttactgtt tggtttgagg   2710

 caccccagtc aactcctaga tttcaaaaac ctttttctaa ttgggagtaa tggcgggcac   2770

 tttcaccaag atgttctaga aacttctgag ccaggagtga atggcccttc cttagtagcc   2830

 tgggggatgt ccagagacta ggcctctccc ctttacccct ccagagaagg ggcttccctg   2890

 tcccggaggg acacggggaa cgggattttc cgtctctccc tcttgccagc tctgtgagtc   2950

 tggccagggc gggtagggag cgtggagggc atctgtctgc catcgcccgc tgccaatcta   3010

 agccagtctc actgtgaacc acacgaaacc tcaactgggg gagtgagggg ctggccaggt   3070

 ctggaggggc ctcaggggtg cccagcccgg cacccagcgc tttcgcccct cgtccaccca   3130

 cccctggctg gcagcctccc tccccacacc cgcccctgtg ctctgctgtc tggaggccac   3190

 gtggatgttc atgagatgca ttctcttctg tctttggtgg atgggatggt ggcaaagccc   3250

 aggatctggc tttgccagag gttgcaacat gttgagagaa cccggtcaat aaagtgtact   3310

 acctcttacc cct                                                      3323




      <210> 23
      <211> 2108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(901)

      <220>
      <221> misc_feature
      <222> (1)...(2108)
      <223> n = a,t,c or g

      <400> 23
 ctgagatgtt ggagacatgg agtgaggccc catggagagg gcagatgagg agggtggatt     60

 agggctgatc ttgggagctg ttgcccccat atccctttga cattcgcctt ggcaaacttt    120

 gtaggcccgg aggagagttc tcaaaacaca gtgagtgtga cctttcacat gcacaaangg    180

 tgttgatcca accgaagcaa tattgattct tgttatattg ctttattgtg gggtcagtgt    240

 cagagtacca cgagttttca tcacgcaccg ttctttcccc agctgcagtg tgtttccgcc    300

 ggccgccccc   atg gcc cgg ctg ggc gcg ctg ctc ctg gcc gcc gcc ctg     349
              Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu
                1               5                  10

 ggt gca ctg ctc agc ttc gcg ctc ctg gcc gcc gcg gtc gcc agc gac      397
 Gly Ala Leu Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp
      15                  20                  25

 tac tgg tac atc ctg gag gtg gcg gac gcc ggc aat ggc agc gcc tgg      445
 Tyr Trp Tyr Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp
  30                  35                  40                  45

 ccc ggg cgc gca gag ctg ctc tcc tcg cac tcg ggg ctc tgg cgc atc      493
 Pro Gly Arg Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile
                  50                  55                  60

 tgc gaa gtg ctg cac cgt gca gtc att gtg gtc ctg ccc ctg agc ctg      541
 Cys Glu Val Leu His Arg Ala Val Ile Val Val Leu Pro Leu Ser Leu
              65                  70                  75

 gtc ctt ctc gtg tgt ggc tgg atc tgc ggc ctg ctc agc tcc ctg gcc      589
 Val Leu Leu Val Cys Gly Trp Ile Cys Gly Leu Leu Ser Ser Leu Ala
          80                  85                  90

 cag agc gtg tct ctg ctg ctt ttc acc ggc tgc tac ttc ctg ctg ggg      637
 Gln Ser Val Ser Leu Leu Leu Phe Thr Gly Cys Tyr Phe Leu Leu Gly
      95                 100                 105

 agt gtc ctg aca ctg gcg ggg gtc agc atc tac atc agc tac tcg cac      685
 Ser Val Leu Thr Leu Ala Gly Val Ser Ile Tyr Ile Ser Tyr Ser His
 110                 115                 120                 125

 ctg gcc ttt gcg gag acg gtg cag cag tat ggc ccg cag cac atg cag      733
 Leu Ala Phe Ala Glu Thr Val Gln Gln Tyr Gly Pro Gln His Met Gln
                 130                 135                 140

 ggc gtc cgc gtc agc ttc ggc tgg tcc atg gcc ctg gcc tgg ggc tcc      781
 Gly Val Arg Val Ser Phe Gly Trp Ser Met Ala Leu Ala Trp Gly Ser
             145                 150                 155

 tgt gcc ttg gag gca ttc agc gga acc ctc ctg ctc tca gct gcc tgg      829
 Cys Ala Leu Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala Ala Trp
         160                 165                 170

 acc ctc agc ctg agc ccc cca atc tgt ggt cat ctg agt ccc cag cag      877
 Thr Leu Ser Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro Gln Gln
     175                 180                 185

 gtg gga ggg aga ggg gga gac tga ggcccagagc ggcagaggga cccacccaga     931
 Val Gly Gly Arg Gly Gly Asp 
 190                 195

 tcgcctggcg ccagagagat gccgtctcag gccaaggcct ccctggcctc tgttctgtcc    991

 actctccccg aagggcaggc ttggtggaga agaggctgat gagagggccc gagagcccct   1051

 ccgatttgca ggggtggggg gcaaggagct gagcgatcca gatgtacccc tctgccccct   1111

 cccttgttct caagcctgct aggtactttt cactgagcac ttccgggaag agcaggcacc   1171

 cagatctctg tccttgtcct ggcacaggct gctgctgctt ccggcccccg acccttcctc   1231

 tctgcagcaa cccgggggag gtatgccact gtgagtgccc tggtgggcac actgagctgg   1291

 cagagatgga agtcccagaa gggtggggtg ggggtgtcat gccatggtgg aggagtttgg   1351

 ggccactcct tgcctgcctc aaagggggcc tggctgaggg tgcttcttga ccacaggggc   1411

 cagggctgcc tagggtggcg cagggctggg cctggagttt gggatgcagg cttgttaaac   1471

 acagggcaga accccaggtt gggaggggct cagtttgcag gcccaggccc gcaggcccac   1531

 tgctggtccc agggtgagac aggtgagaag agggatggcc agcacacact tgagtcccct   1591

 tgggccacaa aggctggggc acgcccaccg ttatgcagat ggacagttga ggtggctgca   1651

 ggagaagggt tcccagggcc tgtacaacac gtggaagcac taaacggccc cgtttggggt   1711

 ttgggggccc ttcccgagtc ttgagaggtc ttgagaggtg tgctggggaa ggtggcagcc   1771

 tcttgtagct tgatcttcct ccaccctgcc ccacccctag gtctctttat tgattcaaag   1831

 gttaaggaag ctcctggggg cttgaggggg tggcacagtt ttggtggggc ccagtgagga   1891

 caaatctggg gggtgagcag ggcctcctct tcctcctggt gtttgaacgt ttaccattcc   1951

 atgtgggacc attgtgccaa tttgtcctta cgtaaatcac ttgtgctgtg tgcagtataa   2011

 gccttttatt tttcttagaa cttttcaaaa taggtaacac atgcctgtct gtcataaaca   2071

 gtacaaacgg gagcaaacac tgtcaaaaaa aaaaaaa                            2108




      <210> 24
      <211> 1496
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (570)..(1280)

      <400> 24
 agagggctgg tgaccaggcc tcaccttcag cctacatgtc cagggatgct tgggagcttt     60

 taataggctc aaaatagatc tcagggcact gggagagaga ggggaaaatg gaagtcacct    120

 ggaagagcag atgggcctgt ccttgagtat ctcagtggtc tctctgagtt gactttggaa    180

 aactctcagc cccaggaaag ctgtccttaa atttctgagg cctcattggc atttatcacc    240

 cacacgagga gtcctgggga ccgggggacc ccaatcataa agggtggggc tctccagtgt    300

 ctggagaagg gtgtgcagca gctgatccat tcactcttct ctctcatcct cttcttcaga    360

 cgtccttcta tggccgcttc aggcacttct tggatatcat cgaccctcgc acactctttg    420

 tcactgagag acgtctcaga gaggctgtgc agctgctgga ggactataag catgggaccc    480

 tgcgcccggg ggtcaccaat gaacagctct ggagtgcaca gaaaatcaag caggctattc    540

 tacatccgga caccaatgag aagatcttc  atg cca ttt aga atg tca ggt tat     593
                                  Met Pro Phe Arg Met Ser Gly Tyr
                                    1               5

 att cct ttt ggg acg cca att gta gtc ggt ctt ctc ttg ccc aac cag      641
 Ile Pro Phe Gly Thr Pro Ile Val Val Gly Leu Leu Leu Pro Asn Gln
      10                  15                  20

 aca ctg gca tcc act gtc ttc tgg cag tgg ctg aac cag agc cac aat      689
 Thr Leu Ala Ser Thr Val Phe Trp Gln Trp Leu Asn Gln Ser His Asn
  25                  30                  35                  40

 gcc tgt gtc aac tat gca aac cgc aat gcg acc aag cct tca cct gca      737
 Ala Cys Val Asn Tyr Ala Asn Arg Asn Ala Thr Lys Pro Ser Pro Ala
                  45                  50                  55

 tcc aag ttc atc cag gga tac ctg gga gct gtc atc agc gcc gtc tcc      785
 Ser Lys Phe Ile Gln Gly Tyr Leu Gly Ala Val Ile Ser Ala Val Ser
              60                  65                  70

 att gct gtg ggc ctt aat gtc ctg gtt cag aaa gcc aac aag ttc acc      833
 Ile Ala Val Gly Leu Asn Val Leu Val Gln Lys Ala Asn Lys Phe Thr
          75                  80                  85

 cca gcc acc cgc ctt ctc atc cag agg ttt gtg ccg ttc cct gct gta      881
 Pro Ala Thr Arg Leu Leu Ile Gln Arg Phe Val Pro Phe Pro Ala Val
      90                  95                 100

 gcc agt gcc aat atc tgc aat gtg gtc ctg atg cgg tac ggg gag ctg      929
 Ala Ser Ala Asn Ile Cys Asn Val Val Leu Met Arg Tyr Gly Glu Leu
 105                 110                 115                 120

 gag gaa ggg att gat gtc ctg gac agc gat ggc aac ctc gtg ggc tcc      977
 Glu Glu Gly Ile Asp Val Leu Asp Ser Asp Gly Asn Leu Val Gly Ser
                 125                 130                 135

 tcc aag atc gca gcc cga cac gcc ctg ctg gag acg gcg ctg acg cga     1025
 Ser Lys Ile Ala Ala Arg His Ala Leu Leu Glu Thr Ala Leu Thr Arg
             140                 145                 150

 gtg gtc ctg ccc atg ccc atc ctg gtg cta ccc ccg atc gtc atg tcc     1073
 Val Val Leu Pro Met Pro Ile Leu Val Leu Pro Pro Ile Val Met Ser
         155                 160                 165

 atg ctg gag aag acg gct ctc ctg cag gca cgc ccc cgg ctg ctc ctc     1121
 Met Leu Glu Lys Thr Ala Leu Leu Gln Ala Arg Pro Arg Leu Leu Leu
     170                 175                 180

 cct gtg caa agc ctc gtg tgc ctg gca gcc ttc ggc ctg gcc ctg ccg     1169
 Pro Val Gln Ser Leu Val Cys Leu Ala Ala Phe Gly Leu Ala Leu Pro
 185                 190                 195                 200

 ctg gcc atc agc ctc ttc ccg caa atg tca gag att gaa aca tcc caa     1217
 Leu Ala Ile Ser Leu Phe Pro Gln Met Ser Glu Ile Glu Thr Ser Gln
                 205                 210                 215

 tta gag ccg gag ata gcc cag gcc acg agc agc cgg aca gtg gtg tac     1265
 Leu Glu Pro Glu Ile Ala Gln Ala Thr Ser Ser Arg Thr Val Val Tyr
             220                 225                 230

 aac aag ggg ttg tga gtgtggtcag cggcctgggg acggagcact gtgcagccgg     1320
 Asn Lys Gly Leu 
         235

 ggagctgagg ggcagggccg tagactcacg gctgcacctg cagggagcag cacgccaacc   1380

 ccagcagtcc tgggccccct gggagagtgc tcaacctaca gtggagggag actgacccat   1440

 tcacatttta acataggcaa gaggagttct aacacatttc gtacaaaaaa aaaaaa       1496




      <210> 25
      <211> 1867
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (201)..(1844)

      <400> 25
 gcccaccgcg ctcagccaga cgttcaacgc tcggacaagc atggtctata acccaggaaa     60

 ggggagcagg gccactcccg cgggcggccc cagcgatgaa ccggacgccc ccaccctgcc    120

 gggaaaaaag cagtggcggt caggccgcgc tgtctcttta agatcgtgtt cctactaaca    180

 ctgacgatgc agaggcctcc    atg gct gtg ata agc ctg ctg ttc ttg gca     230
                          Met Ala Val Ile Ser Leu Leu Phe Leu Ala
                            1               5                  10

 gtg atg tat gtt gtt cac cac cct ctg atg gtc agt gat cgg atg gac      278
 Val Met Tyr Val Val His His Pro Leu Met Val Ser Asp Arg Met Asp
                  15                  20                  25

 ctg gac aca tta gcc agg agt cgg cag ctg gag aag cga atg agt gag      326
 Leu Asp Thr Leu Ala Arg Ser Arg Gln Leu Glu Lys Arg Met Ser Glu
              30                  35                  40

 gag atg cgc ctg cta gag atg gag ttt gaa gag aga aag cga gcc gct      374
 Glu Met Arg Leu Leu Glu Met Glu Phe Glu Glu Arg Lys Arg Ala Ala
          45                  50                  55

 gag cag agg cag aag gca gag aac ttc tgg aca gga gac aca tcc agt      422
 Glu Gln Arg Gln Lys Ala Glu Asn Phe Trp Thr Gly Asp Thr Ser Ser
      60                  65                  70

 gac cag tta gtg ctg ggg aag aaa gac atg ggg tgg ccg ttc cag gcc      470
 Asp Gln Leu Val Leu Gly Lys Lys Asp Met Gly Trp Pro Phe Gln Ala
  75                  80                  85                  90

 gat ggc cag gaa ggg cct ctg ggc tgg atg ctg gga aac ctg tgg aac      518
 Asp Gly Gln Glu Gly Pro Leu Gly Trp Met Leu Gly Asn Leu Trp Asn
                  95                 100                 105

 act ggc ctc ttt tgc ctt ttt ctc gtc ttt gag ctc ctg cga cag aac      566
 Thr Gly Leu Phe Cys Leu Phe Leu Val Phe Glu Leu Leu Arg Gln Asn
             110                 115                 120

 atg cag cat gaa ccg gcc ttt gat tcc agc agt gag gag gag gag gag      614
 Met Gln His Glu Pro Ala Phe Asp Ser Ser Ser Glu Glu Glu Glu Glu
         125                 130                 135

 gaa gtc cgt gtt gtc cct gtc acc tct tac aac tgg ctt act gac ttc      662
 Glu Val Arg Val Val Pro Val Thr Ser Tyr Asn Trp Leu Thr Asp Phe
     140                 145                 150

 ccc tcc cag gag gcc ctg gac tcc ttt tac aaa cac tat gtc caa aat      710
 Pro Ser Gln Glu Ala Leu Asp Ser Phe Tyr Lys His Tyr Val Gln Asn
 155                 160                 165                 170

 gcc atc cgt gac ctg ccc tgc acc tgt gag ttt gtg gag agt ttt gtg      758
 Ala Ile Arg Asp Leu Pro Cys Thr Cys Glu Phe Val Glu Ser Phe Val
                 175                 180                 185

 gat gat ctc att gag gcc tgt cgg gtg ctc agc cgc caa gag gct cac      806
 Asp Asp Leu Ile Glu Ala Cys Arg Val Leu Ser Arg Gln Glu Ala His
             190                 195                 200

 cca caa ttg gaa gac tgc ctg ggc atc ggg gct gcc ttt gag aaa tgg      854
 Pro Gln Leu Glu Asp Cys Leu Gly Ile Gly Ala Ala Phe Glu Lys Trp
         205                 210                 215

 gga acc ctc cat gag acc cag aaa ttt gat atc ctg gtg ccc att gtc      902
 Gly Thr Leu His Glu Thr Gln Lys Phe Asp Ile Leu Val Pro Ile Val
     220                 225                 230

 ccc cca cag ggc acc atg ttt gtc ctg gag atg agg gac cca gcc ctg      950
 Pro Pro Gln Gly Thr Met Phe Val Leu Glu Met Arg Asp Pro Ala Leu
 235                 240                 245                 250

 ggc cgc cgc tgt ggc tgt gtg ctg gtg gag tca gaa tgt gtg tgc aag      998
 Gly Arg Arg Cys Gly Cys Val Leu Val Glu Ser Glu Cys Val Cys Lys
                 255                 260                 265

 cgt gag aaa ctc cta ggg gac gtg ctg tgc ctg gtg cac cac cac agg     1046
 Arg Glu Lys Leu Leu Gly Asp Val Leu Cys Leu Val His His His Arg
             270                 275                 280

 gac ccc tcg gca gtc ttg ggg aag tgt agt agc tcc atc aag gca gct     1094
 Asp Pro Ser Ala Val Leu Gly Lys Cys Ser Ser Ser Ile Lys Ala Ala
         285                 290                 295

 ctc tgc acc ggc ttc cac cta gac gtg tgc aag act gtg cag tgg ttc     1142
 Leu Cys Thr Gly Phe His Leu Asp Val Cys Lys Thr Val Gln Trp Phe
     300                 305                 310

 cgg aac atg atg ggc aat gcc tgg gcc ctt gtg gcc cac aag tat gac     1190
 Arg Asn Met Met Gly Asn Ala Trp Ala Leu Val Ala His Lys Tyr Asp
 315                 320                 325                 330

 ttt aaa ctc agt ctc cca ccg tct acc acc tcc tgc aag ctc cgg ctg     1238
 Phe Lys Leu Ser Leu Pro Pro Ser Thr Thr Ser Cys Lys Leu Arg Leu
                 335                 340                 345

 gac tat cgc tca ggc cgc ttt ctc tca atc cac ttg gtc ctg ggg gtg     1286
 Asp Tyr Arg Ser Gly Arg Phe Leu Ser Ile His Leu Val Leu Gly Val
             350                 355                 360

 caa cga gaa gac acc ttg gtc tac ctg gtg agt cag gct cct gac cag     1334
 Gln Arg Glu Asp Thr Leu Val Tyr Leu Val Ser Gln Ala Pro Asp Gln
         365                 370                 375

 gag cag ctc acc agt gtg gac tgg cct gag tcc ttt gtg gcc tgt gag     1382
 Glu Gln Leu Thr Ser Val Asp Trp Pro Glu Ser Phe Val Ala Cys Glu
     380                 385                 390

 cac ctg ttc ctg aag ctg gtg ggg cgc ttt gcc ccc gag aac acc tgt     1430
 His Leu Phe Leu Lys Leu Val Gly Arg Phe Ala Pro Glu Asn Thr Cys
 395                 400                 405                 410

 cac ctc aag tgc ctc cag atc att tta agt ctc cgg cag cat cag agc     1478
 His Leu Lys Cys Leu Gln Ile Ile Leu Ser Leu Arg Gln His Gln Ser
                 415                 420                 425

 tta ccc cat gga gca tcc cgc ccc atc ctc act tct tac cat ttt aaa     1526
 Leu Pro His Gly Ala Ser Arg Pro Ile Leu Thr Ser Tyr His Phe Lys
             430                 435                 440

 aca gct ctc atg cac ctc ttg cta cgg ctg ccc ctc acg gac tgg gcc     1574
 Thr Ala Leu Met His Leu Leu Leu Arg Leu Pro Leu Thr Asp Trp Ala
         445                 450                 455

 cac aac atg ctc tct cag cgg ctc cag gac att ctc tgg ttc ttg ggc     1622
 His Asn Met Leu Ser Gln Arg Leu Gln Asp Ile Leu Trp Phe Leu Gly
     460                 465                 470

 cgt ggc ctc cag caa agg tcc ctc cat cat ttc ctc att ggt aac aat     1670
 Arg Gly Leu Gln Gln Arg Ser Leu His His Phe Leu Ile Gly Asn Asn
 475                 480                 485                 490

 ttt ctg ccc ctg acc atc cca atc cct aag aca ttt agg aat gct gag     1718
 Phe Leu Pro Leu Thr Ile Pro Ile Pro Lys Thr Phe Arg Asn Ala Glu
                 495                 500                 505

 ccg gtc aat ctc ttc caa cac ctg gtg ctc aac ccc aag gca cat tca     1766
 Pro Val Asn Leu Phe Gln His Leu Val Leu Asn Pro Lys Ala His Ser
             510                 515                 520

 cag gca gtg gaa gag ttc caa aac ctt ctg acc cag gtg aaa act ctg     1814
 Gln Ala Val Glu Glu Phe Gln Asn Leu Leu Thr Gln Val Lys Thr Leu
         525                 530                 535

 cct cat gcc cca ctg gct gca gca cct tga t gtaaagacca ttaaaaaaaa     1865
 Pro His Ala Pro Leu Ala Ala Ala Pro 
     540                 545

 aa                                                                  1867




      <210> 26
      <211> 1108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(858)

      <400> 26
 gtcggttggg aagccgtgtc tcgcagtcgt ggactcgtgc agctggggcg tccgcagccg     60

 ctcgtcaccc gcgtg atg ctg ttt ctg gcg ttg ggc agc ccg tgg gcg gtc     111
                  Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val
                    1               5                  10

 gaa ctg cct ctc tgc gga agg agg act gca ttg tgt gcg gcc gcc gcg      159
 Glu Leu Pro Leu Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala
          15                  20                  25

 ctc cga ggt ccc cgg gcc tct gtc tcc cgg gcg tcc tcc agc agc ggg      207
 Leu Arg Gly Pro Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly
      30                  35                  40

 cct tcg ggg ccg gta gcc ggc tgg agt acg ggg cct tcg gga gcc gcg      255
 Pro Ser Gly Pro Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala
  45                  50                  55                  60

 cgc ctt ctc cgg cgt ccg ggt cga gcg cag atc cct gtt tat tgg gaa      303
 Arg Leu Leu Arg Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu
                  65                  70                  75

 gga tat gtt cga ttc tta aat acg cca tct gac aaa tca gaa gat gga      351
 Gly Tyr Val Arg Phe Leu Asn Thr Pro Ser Asp Lys Ser Glu Asp Gly
              80                  85                  90

 agg cta att tat act ggc aat atg gcc cga gca gtg ttt ggt gtg aaa      399
 Arg Leu Ile Tyr Thr Gly Asn Met Ala Arg Ala Val Phe Gly Val Lys
          95                 100                 105

 tgt ttc tct tat tct acg agt ctg att ggc ctt aca ttt ctg cca tac      447
 Cys Phe Ser Tyr Ser Thr Ser Leu Ile Gly Leu Thr Phe Leu Pro Tyr
     110                 115                 120

 att ttt aca caa aat aat gct att tct gaa agt gtg cct ctg cct att      495
 Ile Phe Thr Gln Asn Asn Ala Ile Ser Glu Ser Val Pro Leu Pro Ile
 125                 130                 135                 140

 caa atc ata ttc tat ggc atc atg gga agc ttt acg gtg atc acc cca      543
 Gln Ile Ile Phe Tyr Gly Ile Met Gly Ser Phe Thr Val Ile Thr Pro
                 145                 150                 155

 gtg ctg ctt cac ttt att aca aaa ggc tat gtc att cga ttg tac cat      591
 Val Leu Leu His Phe Ile Thr Lys Gly Tyr Val Ile Arg Leu Tyr His
             160                 165                 170

 gag gcc aca aca gac act tat aaa gcc att acc tac aat gct atg ctt      639
 Glu Ala Thr Thr Asp Thr Tyr Lys Ala Ile Thr Tyr Asn Ala Met Leu
         175                 180                 185

 gca gaa acg agt aca gtg ttt cac cag aat gat gtg aag att cca gat      687
 Ala Glu Thr Ser Thr Val Phe His Gln Asn Asp Val Lys Ile Pro Asp
     190                 195                 200

 gct aaa cat gta ttt acc aca ttt tat gct aaa aca aaa tca ctg tta      735
 Ala Lys His Val Phe Thr Thr Phe Tyr Ala Lys Thr Lys Ser Leu Leu
 205                 210                 215                 220

 gtt aat cca gtg ctc ttt cca aac cgt gaa gac tat atc cat cta atg      783
 Val Asn Pro Val Leu Phe Pro Asn Arg Glu Asp Tyr Ile His Leu Met
                 225                 230                 235

 ggt tat gac aaa gaa gaa ttt att ttg tat atg gaa gaa acc agt gaa      831
 Gly Tyr Asp Lys Glu Glu Phe Ile Leu Tyr Met Glu Glu Thr Ser Glu
             240                 245                 250

 gag aaa cgg cat aaa gat gac aaa tga gccta tttgttagtg ttcgtgctca      883
 Glu Lys Arg His Lys Asp Asp Lys 
         255                 260

 aatgtgattt acgttttaat gtataataat aaaattgcct tttgcattcc gttagtgact    943

 gattgttaaa aataatttga aattatcaaa gcttttaatt tccagagaat gatgtttgtt   1003

 tataataaaa caagctatgt ttgaaaacca aaatgtagta tctaccattc gtgttttaga   1063

 aaggtatgtg aataaatatg ttcatgctag tataagaaaa aaaaa                   1108




      <210> 27
      <211> 1835
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (475)..(1410)

      <400> 27
 agctaaccta cttctgtaga acttctgttt cagcctctca cacaccacaa ggaccattgt     60

 cgtctcatca tcctcagggc taagttgcag accattgtcc accactctgt ggagggtgct    120

 atagtgttgc tggctttggt ggaaagaatg cagctctgaa gcagcctccc aggcagcaaa    180

 cgtaggcatg ggaaaaggat ctggcctctt gttttcaaaa aaacatttca ggttcctctc    240

 gctcagcttg ttggcatagt ccagaaatgt attttccaac tgctccttct ccttttgtgc    300

 atatgtcttc caaaaactca gctgaaggta gctaacttta gatcggcagc gagcataaca    360

 tgtggtgagc agagagaaga aagacgcact tgttttgctt ttgggaatgc aattcttact    420

 acctataaat gggaagttag tccttcctaa ggctgtacat ctggatttgt gttc  atg     477
                                                              Met
                                                                1

 tgc atg gat gct ttt cag ggc att tta aaa ttc ttc ctt aat cag aaa      525
 Cys Met Asp Ala Phe Gln Gly Ile Leu Lys Phe Phe Leu Asn Gln Lys
               5                  10                  15

 act gtt att ggc tac agc ttc atg gct ctg ctg acc gtg gga agt gag      573
 Thr Val Ile Gly Tyr Ser Phe Met Ala Leu Leu Thr Val Gly Ser Glu
          20                  25                  30

 cgt ctc ttt tct gtt gtg gct ttt aag tgc ccc tgc agc act gag aat      621
 Arg Leu Phe Ser Val Val Ala Phe Lys Cys Pro Cys Ser Thr Glu Asn
      35                  40                  45

 atg acc tat ggg ctg gtt ttc ctc ttt gct cct gcc tgg gtg tta ctg      669
 Met Thr Tyr Gly Leu Val Phe Leu Phe Ala Pro Ala Trp Val Leu Leu
  50                  55                  60                  65

 atc ctg gga ttc ttt ctg aac aat agg tcg tgg aga ctc ttc aca ggc      717
 Ile Leu Gly Phe Phe Leu Asn Asn Arg Ser Trp Arg Leu Phe Thr Gly
                  70                  75                  80

 tgc tgt gtg aat ccc agg aaa atc ttt ccc aga ggc cac agc tgc cgt      765
 Cys Cys Val Asn Pro Arg Lys Ile Phe Pro Arg Gly His Ser Cys Arg
              85                  90                  95

 ttc ttc tac gtc ctc ggc cag atc act ctg agc tca ttg gtg gct cca      813
 Phe Phe Tyr Val Leu Gly Gln Ile Thr Leu Ser Ser Leu Val Ala Pro
         100                 105                 110

 gtg atg tgg ctt tct gtg gct ctg ctc aat gga act ttc tat gaa tgt      861
 Val Met Trp Leu Ser Val Ala Leu Leu Asn Gly Thr Phe Tyr Glu Cys
     115                 120                 125

 gcc atg agc ggg acg aga agt tca gga ctc ctg gaa ctg att tgc aag      909
 Ala Met Ser Gly Thr Arg Ser Ser Gly Leu Leu Glu Leu Ile Cys Lys
 130                 135                 140                 145

 ggt aag ccc aaa gag tgc tgg gaa gaa ctt cac aaa gta tct tgt ggc      957
 Gly Lys Pro Lys Glu Cys Trp Glu Glu Leu His Lys Val Ser Cys Gly
                 150                 155                 160

 aaa act agc atg cta cct acc gtc aat gaa gaa ctg aaa ctc tcc ctt     1005
 Lys Thr Ser Met Leu Pro Thr Val Asn Glu Glu Leu Lys Leu Ser Leu
             165                 170                 175

 cag gcc cag tct cag att cta gga tgg tgc ctg att tgt tca gcg tct     1053
 Gln Ala Gln Ser Gln Ile Leu Gly Trp Cys Leu Ile Cys Ser Ala Ser
         180                 185                 190

 ttc ttc tct ctg ctc acc aca tgt tat gct cgc tgc cga tct aaa gtt     1101
 Phe Phe Ser Leu Leu Thr Thr Cys Tyr Ala Arg Cys Arg Ser Lys Val
     195                 200                 205

 agc tac ctt cag ctg agt ttt tgg aag aca tat gca caa aag gag aag     1149
 Ser Tyr Leu Gln Leu Ser Phe Trp Lys Thr Tyr Ala Gln Lys Glu Lys
 210                 215                 220                 225

 gag cag ttg gaa aat aca ttt ctg gac tat gcc aac aag ctg agc gag     1197
 Glu Gln Leu Glu Asn Thr Phe Leu Asp Tyr Ala Asn Lys Leu Ser Glu
                 230                 235                 240

 agg aac ctg aaa tgt ttt ttt gaa aac aag agg cca gat cct ttt ccc     1245
 Arg Asn Leu Lys Cys Phe Phe Glu Asn Lys Arg Pro Asp Pro Phe Pro
             245                 250                 255

 atg cct acg ttt gct gcc tgg gag gct gct tca gag ctg cat tct ttc     1293
 Met Pro Thr Phe Ala Ala Trp Glu Ala Ala Ser Glu Leu His Ser Phe
         260                 265                 270

 cac caa agc cag caa cac tat agc acc ctc cac aga gtg gtg gac aat     1341
 His Gln Ser Gln Gln His Tyr Ser Thr Leu His Arg Val Val Asp Asn
     275                 280                 285

 ggt ctg caa ctt agc cct gag gat gat gag acg aca atg gtc ctt gtg     1389
 Gly Leu Gln Leu Ser Pro Glu Asp Asp Glu Thr Thr Met Val Leu Val
 290                 295                 300                 305

 ggt act gcc cac aat atg tag ct catccaccat caatgactca tggtgttgag     1442
 Gly Thr Ala His Asn Met 
                 310

 tggcatgctc attctgtgat cctcctaacg tatcaccaga caacctgtgt tgtctctgta   1502

 ttttcttaca tttggagtat gttacaagac ataaccccaa ggaacggctt ggaagctctc   1562

 agtagaactt caggaggtgc tccaatgatg ccgagggtgg ccagggtgcc cggctggggg   1622

 gaggggggcc aaggccaaag tgggtcccga atcaatttct tcacgagcaa ccttgagagg   1682

 gccagttcga aatgtgcgga atggggcggc agcgtgggtg ggcgacctca atgggccaga   1742

 ggccgggaga ggagtccaca actcagggta gagagcccgc ctacacaaag agtgttcagt   1802

 cgggtgtcgt tttacactct atatcgatcg tcc                                1835




      <210> 28
      <211> 463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(423)

      <400> 28
 cccacgcgtc cgcccacgcg tccgggccac acgcctcagc cagccccggc aagggcctat     60

 caggggtggg tcggggcatc cgagcgggtt tgacggaagg agcggcggcg acggaggagg    120

 agg  atg gag gcg gtg gtg ttc gtc ttc tct ctc ctc gat tgt tgc gcg     168
      Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala
        1               5                  10                  15

 ctc atc ttc ctc tcg gtc tac ttc ata att aca ttg tct gat tta gaa      216
 Leu Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu
                  20                  25                  30

 tgt gat tac att aat gct aga tca tgt tgc tca aaa tta aac aag tgg      264
 Cys Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp
              35                  40                  45

 gta att cca gaa ttg att ggc cat acc att gtc act gta tta ctg ctc      312
 Val Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu
          50                  55                  60

 atg tca ttg cac tgg ttc atc ttc ctt ctc aac tta cct gtt gcc act      360
 Met Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr
      65                  70                  75

 tgg aat ata tat cga tac att atg gtg ccg agt ggt aac aaa tac aca      408
 Trp Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Lys Tyr Thr
  80                  85                  90                  95

 atc gag ggc agc tga agtcacacat gaaagaagcc atgatcaagc ttggtttcca      463
 Ile Glu Gly Ser 






      <210> 29
      <211> 4706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (258)..(914)

      <400> 29
 ctaaaggagg cagatcagat ttttcccctc ttcaatttct tcctgtactt tgtcactaga     60

 ggttgcaatt tctgcttgtg cagagaagac agcacagatg aaagtgagga ctgtgccccc    120

 aatggcggta taaaaggccc agcccaagga gcagtctcca ggtttgtagg cagatgcata    180

 atgtccacag tagtctatgg ccttctggca accccagcca gcagggtaga gtatcaaacc    240

 gaggataagg aatagac   atg ctc tgg acc ttg ctg agt att gtg gtg gct     290
                      Met Leu Trp Thr Leu Leu Ser Ile Val Val Ala
                        1               5                  10

 ttt gcc gag ctc att gcc ttc atg agt gca gac tgg ctg atc ggg aaa      338
 Phe Ala Glu Leu Ile Ala Phe Met Ser Ala Asp Trp Leu Ile Gly Lys
              15                  20                  25

 gcg agg agc cgc ggc ggc gtg gag ccg gcg ggc ccg ggc ggg ggc tcc      386
 Ala Arg Ser Arg Gly Gly Val Glu Pro Ala Gly Pro Gly Gly Gly Ser
          30                  35                  40

 ccg gag ccc tac cac ccc acc ctg ggc atc tac gcc cgc tgc atc cgg      434
 Pro Glu Pro Tyr His Pro Thr Leu Gly Ile Tyr Ala Arg Cys Ile Arg
      45                  50                  55

 aac cca ggg gtg cag cac ttc cag cgg gac acg ctg tgc ggg ccc tac      482
 Asn Pro Gly Val Gln His Phe Gln Arg Asp Thr Leu Cys Gly Pro Tyr
  60                  65                  70                  75

 gcc gag agc ttc ggc gag atc gcc agc ggc ttc tgg cag gcc aca gct      530
 Ala Glu Ser Phe Gly Glu Ile Ala Ser Gly Phe Trp Gln Ala Thr Ala
                  80                  85                  90

 att ttc ctg gct gtg gga atc ttt att ctc tgc atg gtg gcc ttg gtg      578
 Ile Phe Leu Ala Val Gly Ile Phe Ile Leu Cys Met Val Ala Leu Val
              95                 100                 105

 tcc gtc ttc acc atg tgt gta cag agc atc atg aag aaa agc atc ttc      626
 Ser Val Phe Thr Met Cys Val Gln Ser Ile Met Lys Lys Ser Ile Phe
         110                 115                 120

 aat gtc tgt ggg ctg ttg caa gga att gca ggt cta ttc ctt atc ctc      674
 Asn Val Cys Gly Leu Leu Gln Gly Ile Ala Gly Leu Phe Leu Ile Leu
     125                 130                 135

 ggt ttg ata ctc tac cct gct ggc tgg ggt tgc cag aag gcc ata gac      722
 Gly Leu Ile Leu Tyr Pro Ala Gly Trp Gly Cys Gln Lys Ala Ile Asp
 140                 145                 150                 155

 tac tgt gga cat tat gca tct gcc tac aaa cct gga gac tgc tcc ttg      770
 Tyr Cys Gly His Tyr Ala Ser Ala Tyr Lys Pro Gly Asp Cys Ser Leu
                 160                 165                 170

 ggc tgg gcc ttt tat acc gcc att ggg ggc aca gtc ctc act ttc atc      818
 Gly Trp Ala Phe Tyr Thr Ala Ile Gly Gly Thr Val Leu Thr Phe Ile
             175                 180                 185

 tgt gct gtc ttc tct gca caa gca gaa att gca acc tct agt gac aaa      866
 Cys Ala Val Phe Ser Ala Gln Ala Glu Ile Ala Thr Ser Ser Asp Lys
         190                 195                 200

 gta cag gaa gaa att gaa gag ggg aaa aat ctg atc tgc ctc ctt tag      914
 Val Gln Glu Glu Ile Glu Glu Gly Lys Asn Leu Ile Cys Leu Leu 
     205                 210                 215

 tttggaagag acaatgccat tttctccctt gagtaatctt gtgaaacagt ccacagtttc    974

 atcatttgag tcaagtggag aactaacctt tacctaccaa agccacgttc cacggcccga   1034

 ggcttaaaca ggaccaatga gaggccacat ccagctacgc aaagttactg gacatgcggt   1094

 ctgcagtgca cattataagg aatggaacat gaaaatagta tataatacct agacctggag   1154

 ttgccaagta tctgtcagac tccatctcac cccaggtaca atgatggatg ataatctaaa   1214

 tcattagggc agcagtaatc tctggctaac ggaagagacc gtccgccaga tctgcaggct   1274

 gtttctgctc caacactgct agctttgtag agcatctctg cctcagcaat ggggatcaga   1334

 ggttagagta ccgcaaaccc tctgtacata caaggtcgtc tccaacgaac cagcaaatat   1394

 aaaattaaca gggacaggat gtgtgctaaa gggcacagca agacactgtc ttttgcttag   1454

 ctgaccaaag gggtcagcag ggatggcgtg gagtcatgct gtggaactta ttctaggctg   1514

 aatcctaggg taaggtggat caactgaact gtcactccag agattttaga aatttgagta   1574

 aagaaacaat aaggacctat acaatcatat gagaacaaaa atatgaaatc ttgctagtga   1634

 agacgtattt tttcttcttc ccagcagcca ggctagcacc agttctggcc cagtctcctc   1694

 ttcttctgga gatcacatgt ttttcttcta aggttaggat tgtgctttga ctgcgaaagg   1754

 aaacctcact gtttcctcct tccagggact gagggtctcc aagctagctg tggcttatgc   1814

 agatgttcac tgggaggacc tgccagaatc tcggcacttg gggggagacc tttactccca   1874

 gtttggtgac catgctgtag tcagctctat ttccaatccc gacagtagca gaatggcatt   1934

 ctacaacaaa aagaagctag ttatgggagt taagtttttg tagttactgg tgttgatcct   1994

 gaaagcagac tgagataaca ttaaattgct gcaactgaag aactgcagcc aagaccttaa   2054

 ttccaggaaa gcacagagga caaagttaat tcaaaaagag gcgctagatc aaggtcacag   2114

 cactgcctac acctgtttac aaaaagaatc aaataccact atgaataagg attcaggggt   2174

 ttttaatcta ctttccataa attaccaata tcactgattc aggaagatag tatctcagaa   2234

 tgaccagagc agcacagaaa caagctactc tgacattatg ggagcttcaa aattgtatca   2294

 tgatacagaa acactcctta gcactttaag aaagtgagat ggaactgcca gatttctgga   2354

 aggagaaaaa gtgtaggtat ttgggttcat taatctgctc acttgaggac tttgttttga   2414

 aaaagtacct tctgtggaca aggtattgtg ctaccagcta tacaaccctg acttcagagt   2474

 ttgcaacctt gccctgagtg aatcatgtta aagctgtctg agtctaaagc accgtatctt   2534

 ggtgcagaac agataattat acagagatgg aatgggacaa ccgcagtttt actacattct   2594

 ggtgtttggc ctatatgaga aaccatcttc tcacagatta agggctaagg gcaaaagggg   2654

 tgggaggtgt ggaactagcc ttaatgagtt tcccattcct gaaccaaaat tcaaagtgag   2714

 tgagatgtaa atcctgtgat tttggtgaag aaaaaaacgg gtatcttcat agcagcctag   2774

 gaaaccttaa ccatatctct aacaccacac agaaagaggc tggaggagcc actggacaaa   2834

 gcttctgtct ctgtgtgtac atttataatg ttctaaccaa gtctcaaacc ttgatgaaaa   2894

 acacaaaatt tttccataaa cttatcagaa gactcacttt tctttctttc ttggatagag   2954

 aaaccatttt ctgacactag gtttacaatc tcagtgtcct tacaagttaa gtcctaagct   3014

 cacaggatcc tccgagcatg tccatcacct gctctttggc taaggtggca gtgtacctct   3074

 agatcaacct gggaacagtc acaagggagt gtgacttctt ggccataata aactcactcg   3134

 atagtgttta tgttattaat ctgaatgcaa cagaagacaa aagcacaggc atgcacacac   3194

 acagaacccc aaaccactaa aaactaccta aacactgact tagtaaatag taaaaaggta   3254

 atgttgggac ttttaaacct tgaatccatt agccaggctt gggatgaaag gaccatctaa   3314

 aatcatgcta gtctaaacca tgctcttcca cacagctgtt taaaaaccac tgggtatgag   3374

 gaatatgcta gaaagaaatg ttaaaaatag attgttggct cacacttatt tttctaataa   3434

 ataggaccat tattactacc aggaaagtct tatttatttt gcctgaaatt ggcttaaaga   3494

 aagtctcatg acgggatggg atgggctgcg cttctcaatg aactctgagg cagaaatatt   3554

 tgccttggat tctgtggatt ctttaaacct gtgtgctaat aattcaaaca atgttgcatt   3614

 aattgtataa gggtttttgt atagttttca aacatctgtg gtgtaatgat ctttgttaaa   3674

 catatattct gtaaagtgcc atagtctttt tttatgtgta gcatatttaa aaatatatat   3734

 gtatattata catacacaag tttgtgtgaa agatgtgcaa taacaaaggt gtatgtatgt   3794

 tttgttgttt tgttttggaa actggacagg agtcaaaaca gggatgtttg tttctgtttt   3854

 ggcaaaggag agttccacat ttttgccttc atggcttatt cagtaaccca taattttaat   3914

 gctacacaaa tcttatgtga agaaaagact ggtatgaaat cattttttcc tgggtctaaa   3974

 ataatcgcta gtgttatgtc aaagttaagc ccgcacgcca ggcccagtta atgctagtct   4034

 ttcatgtgaa atgtgaagct gccatgttgc cttttctctt agtaggataa ctagtagctg   4094

 gtacataatc actgaggagc tatttcttaa catgctttta tagaccatgc taatgctaga   4154

 ccagtattta agggctaatc tcacacctcc ttagctgtaa gagtctggct tagaacagac   4214

 ctctctgtgc aataacttgt ggccactgga aatccctggg ccggcatttg tattggggtt   4274

 gcaatgactc ccaagggcca aaagagttaa aggcacgact gggatttctt ctgagactgt   4334

 ggtgaaactc cttccaaggc tgagggggtc agtaggtgct ctggagggac tcggcaccac   4394

 ttgatattca acagccactt gagccaaata taaaattgta tttacagctg atggactcaa   4454

 tttgagcctt caaacttgta gttatcctat tatattgtaa actaatacat tgtctagcat   4514

 tgatttggtt cctgtgcata tgtatttaca gctgatggac tcaatttgag ccttcaaact   4574

 tgtagttatc ctattatatt gtaaactaat acattgtcta gcattgattt ggttcctgtg   4634

 catatgtatt ttcactatgt gctcccctcc ccagatctta attaaaccag attttgcaat   4694

 tcaaaaaaaa aa                                                       4706




      <210> 30
      <211> 868
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(794)

      <400> 30
 cggcgggttc cgcacggagg ttgtgacccc tacggagccc cagcttgccc acgcacccca     60

 ctcggcgtcg cgcggcgtgc cctgcttgtc acagaatc    atg gtg tca tgg aaa     113
                                              Met Val Ser Trp Lys
                                                1               5

 ggg att tac ttt ata ctg act ctg ttt tgg gga agc ttt ttt gga agc      161
 Gly Ile Tyr Phe Ile Leu Thr Leu Phe Trp Gly Ser Phe Phe Gly Ser
                  10                  15                  20

 att ttc atg ctg agt ccc ttt tta cct ttg atg ttt gta aac cca tct      209
 Ile Phe Met Leu Ser Pro Phe Leu Pro Leu Met Phe Val Asn Pro Ser
              25                  30                  35

 tgg tat cgc tgg atc aac aac cgc ctt gtg gca aca tgg ctc acc cta      257
 Trp Tyr Arg Trp Ile Asn Asn Arg Leu Val Ala Thr Trp Leu Thr Leu
          40                  45                  50

 cct gtg gca tta ttg gag acc atg ttt ggt gta aaa gtg att ata act      305
 Pro Val Ala Leu Leu Glu Thr Met Phe Gly Val Lys Val Ile Ile Thr
      55                  60                  65

 ggg gat gca ttt gtt cct gga gaa aga agt gtc att atc atg aac cat      353
 Gly Asp Ala Phe Val Pro Gly Glu Arg Ser Val Ile Ile Met Asn His
  70                  75                  80                  85

 cgg aca aga atg gac tgg atg ttc ctg tgg aat tgc ctg atg cga tat      401
 Arg Thr Arg Met Asp Trp Met Phe Leu Trp Asn Cys Leu Met Arg Tyr
                  90                  95                 100

 agc tac ctc aga ttg gag aaa att tgc ctc aaa gcg agt ctc aaa ggt      449
 Ser Tyr Leu Arg Leu Glu Lys Ile Cys Leu Lys Ala Ser Leu Lys Gly
             105                 110                 115

 gtt cct gga tgg gcc atg cag gct gct gcc tat atc ttc att cat agg      497
 Val Pro Gly Trp Ala Met Gln Ala Ala Ala Tyr Ile Phe Ile His Arg
         120                 125                 130

 aaa tgg aag gat gac aag agc cat ttc gaa gac atg att gat tac ttt      545
 Lys Trp Lys Asp Asp Lys Ser His Phe Glu Asp Met Ile Asp Tyr Phe
     135                 140                 145

 tgt gat att cac gaa cca ctt caa ctc ctc ata ttc cca gaa ggg act      593
 Cys Asp Ile His Glu Pro Leu Gln Leu Leu Ile Phe Pro Glu Gly Thr
 150                 155                 160                 165

 gat ctc aca gaa aac agc aag tct cga agt aat gca ttt gct gaa aaa      641
 Asp Leu Thr Glu Asn Ser Lys Ser Arg Ser Asn Ala Phe Ala Glu Lys
                 170                 175                 180

 aat gga ctt cag aaa tat gaa tat gtt tta cat cca aga act aca ggc      689
 Asn Gly Leu Gln Lys Tyr Glu Tyr Val Leu His Pro Arg Thr Thr Gly
             185                 190                 195

 ttt act ttt gtg gta gac cgt cta aga gaa ggt aag cac cca ttt caa      737
 Phe Thr Phe Val Val Asp Arg Leu Arg Glu Gly Lys His Pro Phe Gln
         200                 205                 210

 aat gta ctt ttt aat aaa agt ggc aaa agt cga cgc ggc cct ttc tgt      785
 Asn Val Leu Phe Asn Lys Ser Gly Lys Ser Arg Arg Gly Pro Phe Cys
     215                 220                 225

 aaa aga tga gctcata ctttgcccta gatgccagaa ccttaataaa taccctcttc      841
 Lys Arg 
 230

 aatcaactta taccaagatt gccattg                                        868




      <210> 31
      <211> 922
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (335)..(922)

      <400> 31
 atgcccgagg gcgcggcggc gctgccaggc tgccgctgct gcccctgcgg gccccgggcg     60

 cgcctccgca ggcggcactg cccgcggcgc ggcgtgtgca ccgagcgagt gaaggtatgt    120

 gtggcgggcg cggctggagc tgccgccgcc gccgccgccg cgccagcagg tcctaatgcc    180

 tgtcacttcc caggacgctg gcagcagcag cagcccggag cccccgagcc ctcggcaggt    240

 ttgcgtgtcc ttccccgcga tctgattgga taaagtgggg gctcgacggt ggccgacgtg    300

 ggacagtctg gctgtggcag gggtctcgga aacc    atg ggt tat tgc agt ggc     352
                                          Met Gly Tyr Cys Ser Gly
                                            1               5

 agg tgc acg ctt atc ttt atc tgt ggc atg caa ctg gtt tgt gtg ctg      400
 Arg Cys Thr Leu Ile Phe Ile Cys Gly Met Gln Leu Val Cys Val Leu
              10                  15                  20

 gag agg caa ata ttt gac ttc ctt gga tat cag tgg gca cct atc ctg      448
 Glu Arg Gln Ile Phe Asp Phe Leu Gly Tyr Gln Trp Ala Pro Ile Leu
          25                  30                  35

 gca aat ttt gta cat att att atc gtc att ctt ggt ttg ttt gga act      496
 Ala Asn Phe Val His Ile Ile Ile Val Ile Leu Gly Leu Phe Gly Thr
      40                  45                  50

 att caa tat aga cct cgt tac ata aca gga tat gct gtc tgg cta gtc      544
 Ile Gln Tyr Arg Pro Arg Tyr Ile Thr Gly Tyr Ala Val Trp Leu Val
  55                  60                  65                  70

 ctc tgg gtt acg tgg aat gtg ttt gtt atc tgc ttc tat ttg gag gct      592
 Leu Trp Val Thr Trp Asn Val Phe Val Ile Cys Phe Tyr Leu Glu Ala
                  75                  80                  85

 ggg gac ctc tca aag gaa aca gac ctt atc ctg act ttt aat ata tca      640
 Gly Asp Leu Ser Lys Glu Thr Asp Leu Ile Leu Thr Phe Asn Ile Ser
              90                  95                 100

 atg cac cga tct tgg tgg atg gag aat gga cca gga tgt acg gtg acg      688
 Met His Arg Ser Trp Trp Met Glu Asn Gly Pro Gly Cys Thr Val Thr
         105                 110                 115

 tca gtg aca cct gcc cca gac tgg gcc cca gaa gac cat cgc tac atc      736
 Ser Val Thr Pro Ala Pro Asp Trp Ala Pro Glu Asp His Arg Tyr Ile
     120                 125                 130

 acg gtc tca ggg tgt ttg ctg gag tac cag tac ata gaa gtg gct cat      784
 Thr Val Ser Gly Cys Leu Leu Glu Tyr Gln Tyr Ile Glu Val Ala His
 135                 140                 145                 150

 agt tcc ctc cag att gtc ctc gca gcc ctg aga gtc att tcc ttt ctg      832
 Ser Ser Leu Gln Ile Val Leu Ala Ala Leu Arg Val Ile Ser Phe Leu
                 155                 160                 165

 aga ctg cag gat caa gcc ttt cac aca act agc ctt tta tca gat aat      880
 Arg Leu Gln Asp Gln Ala Phe His Thr Thr Ser Leu Leu Ser Asp Asn
             170                 175                 180

 gag tct gtg tat cta tac tgt gcg tac cgt act tct cag taa              922
 Glu Ser Val Tyr Leu Tyr Cys Ala Tyr Arg Thr Ser Gln 
         185                 190                 195





      <210> 32
      <211> 2732
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(1618)

      <400> 32
 agtacccact gttgtggaat tcaaaccccg ctgacagcca gtccagcccg ggacacgcgc     60

 ccagctttgt agcctcctcc gtcgactcag ccttaggtac cggtcaggca aa    atg     115
                                                              Met
                                                                1

 cgg tcc tcc ctg gct ccg gga gtc tgg ttc ttc cgg gcc ttc tcc agg      163
 Arg Ser Ser Leu Ala Pro Gly Val Trp Phe Phe Arg Ala Phe Ser Arg
               5                  10                  15

 gac agc tgg ttc cga ggc ctc atc ctg ctg ctg acc ttc cta att tac      211
 Asp Ser Trp Phe Arg Gly Leu Ile Leu Leu Leu Thr Phe Leu Ile Tyr
          20                  25                  30

 gcc tgc tat cac atg tcc agg aag cct atc agt atc gtc aag agc cgt      259
 Ala Cys Tyr His Met Ser Arg Lys Pro Ile Ser Ile Val Lys Ser Arg
      35                  40                  45

 ctg cac cag aac tgc tcg gag cag atc aaa ccc atc aat gat act cac      307
 Leu His Gln Asn Cys Ser Glu Gln Ile Lys Pro Ile Asn Asp Thr His
  50                  55                  60                  65

 agt ctc aat gac acc atg tgg tgc agc tgg gcc cca ttt gac aag gac      355
 Ser Leu Asn Asp Thr Met Trp Cys Ser Trp Ala Pro Phe Asp Lys Asp
                  70                  75                  80

 aac tat aag gag tta cta ggg ggc gtg gac aac gcc ttc ctc atc gcc      403
 Asn Tyr Lys Glu Leu Leu Gly Gly Val Asp Asn Ala Phe Leu Ile Ala
              85                  90                  95

 tat gcc atc ggc atg ttc atc agt ggg gtt ttt ggg gag cgg ctt ccg      451
 Tyr Ala Ile Gly Met Phe Ile Ser Gly Val Phe Gly Glu Arg Leu Pro
         100                 105                 110

 ctc cgt tac tac ctc tca gct gga atg ctg ctc agt ggc ctt ttc acc      499
 Leu Arg Tyr Tyr Leu Ser Ala Gly Met Leu Leu Ser Gly Leu Phe Thr
     115                 120                 125

 tcg ctc ttt ggc ctg gga tat ttc tgg aac atc cac gag ctc tgg tac      547
 Ser Leu Phe Gly Leu Gly Tyr Phe Trp Asn Ile His Glu Leu Trp Tyr
 130                 135                 140                 145

 ttt gtg gtc atc cag gtc tgt aat gga ctc gtc cag acc aca ggc tgg      595
 Phe Val Val Ile Gln Val Cys Asn Gly Leu Val Gln Thr Thr Gly Trp
                 150                 155                 160

 ccc tct gtg gtg acc tgt gtt ggc aac tgg ttc ggg aag ggg aag cgg      643
 Pro Ser Val Val Thr Cys Val Gly Asn Trp Phe Gly Lys Gly Lys Arg
             165                 170                 175

 ggg ttc atc atg ggc atc tgg aat tcc cac aca tct gtg ggc aac atc      691
 Gly Phe Ile Met Gly Ile Trp Asn Ser His Thr Ser Val Gly Asn Ile
         180                 185                 190

 ctg ggc tcc ctg atc gcc ggc atc tgg gtg aac ggg cag tgg ggc ctg      739
 Leu Gly Ser Leu Ile Ala Gly Ile Trp Val Asn Gly Gln Trp Gly Leu
     195                 200                 205

 tcg ttc atc gtg cct ggc atc att act gcc gtc atg ggc gtc atc acc      787
 Ser Phe Ile Val Pro Gly Ile Ile Thr Ala Val Met Gly Val Ile Thr
 210                 215                 220                 225

 ttc ctc ttc ctc atc gaa cac cca gaa gat gtg gac tgc gcc cct cct      835
 Phe Leu Phe Leu Ile Glu His Pro Glu Asp Val Asp Cys Ala Pro Pro
                 230                 235                 240

 cag cac cac ggt gag cca gct gag aac cag gac aac cct gag gac cct      883
 Gln His His Gly Glu Pro Ala Glu Asn Gln Asp Asn Pro Glu Asp Pro
             245                 250                 255

 ggg aac agt ccc tgc tct atc agg gag agc ggc ctt gag act gtg gcc      931
 Gly Asn Ser Pro Cys Ser Ile Arg Glu Ser Gly Leu Glu Thr Val Ala
         260                 265                 270

 aaa tgc tcc aag ggg cca tgc gaa gag cct gct gcc atc agc ttc ttt      979
 Lys Cys Ser Lys Gly Pro Cys Glu Glu Pro Ala Ala Ile Ser Phe Phe
     275                 280                 285

 ggg gcg ctc cgg atc cca ggc gtg gtc gag ttc tct ctg tgt ctg ctg     1027
 Gly Ala Leu Arg Ile Pro Gly Val Val Glu Phe Ser Leu Cys Leu Leu
 290                 295                 300                 305

 ttt gcc aag ctg gtc agt tac acc ttc ctc tac tgg ctg ccc ctc tac     1075
 Phe Ala Lys Leu Val Ser Tyr Thr Phe Leu Tyr Trp Leu Pro Leu Tyr
                 310                 315                 320

 atc gcc aat gtg gct cac ttt agt gcc aag gag gct ggg gac ctg tct     1123
 Ile Ala Asn Val Ala His Phe Ser Ala Lys Glu Ala Gly Asp Leu Ser
             325                 330                 335

 aca ctc ttc gat gtt ggt ggc atc ata ggc ggc atc gtg gca ggg ctc     1171
 Thr Leu Phe Asp Val Gly Gly Ile Ile Gly Gly Ile Val Ala Gly Leu
         340                 345                 350

 gtc tct gac tac acc aat ggc agg gcc acc act tgc tgt gtc atg ctc     1219
 Val Ser Asp Tyr Thr Asn Gly Arg Ala Thr Thr Cys Cys Val Met Leu
     355                 360                 365

 atc ttg gct gcc ccc atg atg ttc ctg tac aac tac att ggc cag gac     1267
 Ile Leu Ala Ala Pro Met Met Phe Leu Tyr Asn Tyr Ile Gly Gln Asp
 370                 375                 380                 385

 ggg att gcc agc tcc ata gtg atg ctg atc atc tgt ggg ggc ctg gtc     1315
 Gly Ile Ala Ser Ser Ile Val Met Leu Ile Ile Cys Gly Gly Leu Val
                 390                 395                 400

 aat ggc cca tac gcg ctc atc acc act gct gtc tct gct gat ctg ggg     1363
 Asn Gly Pro Tyr Ala Leu Ile Thr Thr Ala Val Ser Ala Asp Leu Gly
             405                 410                 415

 act cac aag agc ctg aag ggc aac gcc aaa gcc ctg tcc acg gtc acg     1411
 Thr His Lys Ser Leu Lys Gly Asn Ala Lys Ala Leu Ser Thr Val Thr
         420                 425                 430

 gcc atc att gac ggc acc ggc tcc ata ggt gcg gct ctg ggg cct ctg     1459
 Ala Ile Ile Asp Gly Thr Gly Ser Ile Gly Ala Ala Leu Gly Pro Leu
     435                 440                 445

 ctg gct ggg ctc atc tcc ccc acg ggc tgg aac aat gtc ttc tac atg     1507
 Leu Ala Gly Leu Ile Ser Pro Thr Gly Trp Asn Asn Val Phe Tyr Met
 450                 455                 460                 465

 ctc atc tct gcc gac gtc cta gcc tgc ttg ctc ctt tgc cgg tta gta     1555
 Leu Ile Ser Ala Asp Val Leu Ala Cys Leu Leu Leu Cys Arg Leu Val
                 470                 475                 480

 tac aaa gag atc ttg gcc tgg aag gtg tcc ctg agc aga ggc agc ggg     1603
 Tyr Lys Glu Ile Leu Ala Trp Lys Val Ser Leu Ser Arg Gly Ser Gly
             485                 490                 495

 tat aaa gaa ata tga ggccccaatt ggaacagcag catggagggt cccagttggg     1658
 Tyr Lys Glu Ile 
         500

 tccccaacgt gctccccatg ggcaagacaa tggaaacttc cacaagcagg gaaggcaaac   1718

 cctctttatt gaacattagc cagcccagcc cagaccccag ggctgcctaa ggacacagag   1778

 attctccatg ggaaggggac tgccaagcat gaggaaatag aagattcagg ggcctgagct   1838

 ctggaagctg caagcaaaag ggatgggact agggctgagt tgtgtctcca ttttgataag   1898

 gaaaggatat gctcagactc ttgcttgttc agattccaag acagaaggct tcacaaggcc   1958

 aacgcctgga aaatgggcat ctctccttcc catgttaagc tttaacctct gtaatctgcc   2018

 tgtatctata ggtgggcatc tcactccacc aaaggagccc agcctctctt tgtccctcta   2078

 tccatgcaac agtcttctct gtgcatttcc ccaagctggg ccctcttcta ctctccattt   2138

 aggcctgttg ataactccat tacccgccca tcactgctgt tcctccaggg ccagcactcg   2198

 ggcgaggcag gggagctgcc ttcggtacat aatttgaagg ggcactccct cttggggcac   2258

 atgccggccc tgagtgcctc ccttgcctca ctctgatcct ggccccataa tgtcctcagt   2318

 ggaaggtgat gggggccggt gctgtgggga gagtagaaag aggggttggc atgactaaaa   2378

 ataccagtat gtgtattaag tattttgaga atgaaatgcc aaggagtgcc tactatatgc   2438

 cagctctagg aatggagtag acagtggaca caagaaggac ttacgccctg agcacaggtg   2498

 ccaatggtga caagactggc aagacgtgag ggcatgaatg gttcattcag gcagctgctg   2558

 cagatgtggt cacctggtgc catctgctgc tcccttttcc acttttctat gtcctccttc   2618

 caccccaagt cccggatcac tcgctgtttt ctggctagct cttggcatct ccatctgagc   2678

 ctaaagttgc ccactggcac caatagattc tgtttgacct gcaaaaaaaa aaaa         2732




      <210> 33
      <211> 1169
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(822)

      <400> 33
 atgaatgcag ctcaaagcca ttatcctaag cgaactaatg caggaacagg aaaccaaata     60

 tcacatgttc ttacttgtaa acaggcaaaa atatca  atg gga gaa gaa aac caa     114
                                          Met Gly Glu Glu Asn Gln
                                            1               5

 acc ttt gtg tcc aag ttt atc ttc ctg ggt ctt tca cag gac ttg cag      162
 Thr Phe Val Ser Lys Phe Ile Phe Leu Gly Leu Ser Gln Asp Leu Gln
              10                  15                  20

 acc cag atc ctg cta ttt atc ctt ttc ctc atc att tat ctg ctg acc      210
 Thr Gln Ile Leu Leu Phe Ile Leu Phe Leu Ile Ile Tyr Leu Leu Thr
          25                  30                  35

 gtg ctt gga aac cag ctc atc atc att ctc atc ttc ctg gat tct cgc      258
 Val Leu Gly Asn Gln Leu Ile Ile Ile Leu Ile Phe Leu Asp Ser Arg
      40                  45                  50

 ctt cac act ccc atg tat ttt ttt ctt aga aat ctc tcc ttt gca gat      306
 Leu His Thr Pro Met Tyr Phe Phe Leu Arg Asn Leu Ser Phe Ala Asp
  55                  60                  65                  70

 ctc tgt ttc tct act agc att gtc cct caa gtg ttg gtt cac ttc ttg      354
 Leu Cys Phe Ser Thr Ser Ile Val Pro Gln Val Leu Val His Phe Leu
                  75                  80                  85

 gta aag agg aaa acc att tct ttt tat ggg tgt atg aca cag ata att      402
 Val Lys Arg Lys Thr Ile Ser Phe Tyr Gly Cys Met Thr Gln Ile Ile
              90                  95                 100

 gtc ttt ctt ctg gtt ggg tgt aca gag tgt gcg ctg ctg gca gtg atg      450
 Val Phe Leu Leu Val Gly Cys Thr Glu Cys Ala Leu Leu Ala Val Met
         105                 110                 115

 tcc tat gac cgg tat gtg gct gtc tgc aag ccc ctg tac tac tct acc      498
 Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys Pro Leu Tyr Tyr Ser Thr
     120                 125                 130

 atc atg aca caa cgg gtg tgt ctc tgg ctg tcc ttc agg tcc tgc caa      546
 Ile Met Thr Gln Arg Val Cys Leu Trp Leu Ser Phe Arg Ser Cys Gln
 135                 140                 145                 150

 cac cat cag cac agg aca ctg ctg ccg gag ctg ctg att ctg gaa act      594
 His His Gln His Arg Thr Leu Leu Pro Glu Leu Leu Ile Leu Glu Thr
                 155                 160                 165

 gaa tat tgc tgc atc cat tgc cac gtg agt cca ttc aca ggg cca gag      642
 Glu Tyr Cys Cys Ile His Cys His Val Ser Pro Phe Thr Gly Pro Glu
             170                 175                 180

 ttc caa gtg tgc ggc gtg ggc ggg gcc tgc aga aag gga cgg ggc tgg      690
 Phe Gln Val Cys Gly Val Gly Gly Ala Cys Arg Lys Gly Arg Gly Trp
         185                 190                 195

 caa agg cct ggt cta cct cac cga tcc ggg tcg cgg ggg ctc cta ggg      738
 Gln Arg Pro Gly Leu Pro His Arg Ser Gly Ser Arg Gly Leu Leu Gly
     200                 205                 210

 ggt tcc ttc cac agc tgg tgc gcg tgc gca aga gtg cga cga ggt tgt      786
 Gly Ser Phe His Ser Trp Cys Ala Cys Ala Arg Val Arg Arg Gly Cys
 215                 220                 225                 230

 tcc gcg gca att tat gaa act cgg agc cgg cag tga gttg agggttcggc      836
 Ser Ala Ala Ile Tyr Glu Thr Arg Ser Arg Gln 
                 235                 240

 gaggtcaggg attcctagtt gcagcgtgat taccaacgcc agctcccttc actgtccaag    896

 acagcgattc cgcggctcct ctgagaactg gcgcttgtga gtgactgaac gggccactgg    956

 agaggagcgg tgctcacggg tatcattctc gtcagcgggc ggtggggacg cggggtcttg   1016

 gaattgggaa tcacgcttga gggcgtccat gcggaacgtg cagctcacct cagcttgctt   1076

 gcagttaccc agtttccacg ctgccctcca aggtctgtgc cggaaaacct ggaggagggc   1136

 gcgagatgcc ttcactgtat gtcataagtt ttg                                1169




      <210> 34
      <211> 773
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (172)..(387)

      <400> 34
 ggcgcggagc cgagcgggcg tccgtcgccg gagctgcaat gagcggcgcc cggaggctgt     60

 gacctgcgcg cggcggcccg accggggccc ctgaatggcg gctcgctgag gcggcggcgg    120

 cggcggcggc ggctcaggct cctcggggcg tggcgtggcg gtgaaggggt g atg ctg     177
                                                          Met Leu
                                                            1

 ttc aag ctc ctg cag aga cag acc tat acc tgc ctg tcc cac agg tat      225
 Phe Lys Leu Leu Gln Arg Gln Thr Tyr Thr Cys Leu Ser His Arg Tyr
           5                  10                  15

 ggg ctc tac gtg tgc ttc ttg ggc gtc gtt gtc acc atc gtc tcc gcc      273
 Gly Leu Tyr Val Cys Phe Leu Gly Val Val Val Thr Ile Val Ser Ala
      20                  25                  30

 ttc cag ttc gga gag gtg gtt ctg gaa tgg agc cga gat caa tac cat      321
 Phe Gln Phe Gly Glu Val Val Leu Glu Trp Ser Arg Asp Gln Tyr His
  35                  40                  45                  50

 gtt ttg ttt gat tcc tat aga gac aat att gct gga aag tcc ttt cag      369
 Val Leu Phe Asp Ser Tyr Arg Asp Asn Ile Ala Gly Lys Ser Phe Gln
                  55                  60                  65

 aat cgg tct gtg agg taa agggaa tttcatcccc ctgtaggatg aggaaaccag      423
 Asn Arg Ser Val Arg 
              70

 gtggctacta cacagcggtt tctgagccct ggccggaatt ctgttgacag cgtcctgtga    483

 aatgggacca ctccccagta aaccactggg gctgaacccc actccattgg tcactcttgc    543

 tgcttaccta tgagggagga gcaaacagcc tcatacctca ttagtgtggg tctttccctt    603

 ggaaggccaa gcttcttagt gccgccattc tggaacgcag tcttcaccat ttcttgtctt    663

 tggggatttt ttttttcctc ttcacaagac agacctcaga atggaaacaa tttttttcaa    723

 caccctcctt ccctttttgc agataaaatg aatcacacaa aaaaaaaaaa               773




      <210> 35
      <211> 1956
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1425)

      <400> 35
 taattttgcc ctaggtctgg ccaggaggcc tcacatccag agacctgccc ccgctcttgc     60

 agtgccaggg cc    atg ggg ctc cgg agc cac cac ctc agc ctg ggc ctt     108
                  Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu
                    1               5                  10

 ctg ctt ctg ttt cta ctc cct gca gag tgc ctg gga gct gag ggc cgg      156
 Leu Leu Leu Phe Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg
          15                  20                  25

 ctg gct ctc aag ctg ttc cgt gac ctc ttt gcc aac tac aca agt gcc      204
 Leu Ala Leu Lys Leu Phe Arg Asp Leu Phe Ala Asn Tyr Thr Ser Ala
      30                  35                  40

 ctg aga cct gtg gca gac aca gac cag act ctg aat gtg acc ctg gag      252
 Leu Arg Pro Val Ala Asp Thr Asp Gln Thr Leu Asn Val Thr Leu Glu
  45                  50                  55                  60

 gtg aca ctg tcc cag atc atc gac atg gat gaa cgg aac cag gtg ctg      300
 Val Thr Leu Ser Gln Ile Ile Asp Met Asp Glu Arg Asn Gln Val Leu
                  65                  70                  75

 acc ctg tat ctg tgg ata cgg cag gag tgg aca gat gcc tac cta cga      348
 Thr Leu Tyr Leu Trp Ile Arg Gln Glu Trp Thr Asp Ala Tyr Leu Arg
              80                  85                  90

 tgg gac ccc aat gcc tat ggt ggc ctg gat gcc atc cgc atc ccc agc      396
 Trp Asp Pro Asn Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro Ser
          95                 100                 105

 agt ctt gtg tgg cgg cca gac atc gta ctc tat aac aaa gcc gac gcg      444
 Ser Leu Val Trp Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Ala
     110                 115                 120

 cag cct cca ggt tcc gcc agc acc aac gtg gtc ctg cgc cac gat ggc      492
 Gln Pro Pro Gly Ser Ala Ser Thr Asn Val Val Leu Arg His Asp Gly
 125                 130                 135                 140

 gcc gtg cgc tgg gac gcg ccg gcc atc acg cgc agc tcg tgc cgc gtg      540
 Ala Val Arg Trp Asp Ala Pro Ala Ile Thr Arg Ser Ser Cys Arg Val
                 145                 150                 155

 gat gta gca gcc ttc ccg ttc gac gcc cag cac tgc ggc ctg acg ttc      588
 Asp Val Ala Ala Phe Pro Phe Asp Ala Gln His Cys Gly Leu Thr Phe
             160                 165                 170

 ggc tcc tgg act cac ggc ggg cac caa ctg gat gtg cgg ccg cgc ggc      636
 Gly Ser Trp Thr His Gly Gly His Gln Leu Asp Val Arg Pro Arg Gly
         175                 180                 185

 gct gca gcc agc ctg gcg gac ttc gtg gag aac gtg gag tgg cgc gtg      684
 Ala Ala Ala Ser Leu Ala Asp Phe Val Glu Asn Val Glu Trp Arg Val
     190                 195                 200

 ctg ggc atg ccg gcg cgg cgg cgc gtg ctc acc tac ggc tgc tgc tcc      732
 Leu Gly Met Pro Ala Arg Arg Arg Val Leu Thr Tyr Gly Cys Cys Ser
 205                 210                 215                 220

 gag ccc tac ccc gac gtc acc ttc acg ctg ctg ctg cgc cgc cgc gcc      780
 Glu Pro Tyr Pro Asp Val Thr Phe Thr Leu Leu Leu Arg Arg Arg Ala
                 225                 230                 235

 gcc gcc tac gtg tgc aac ctg ctg ctg ccc tgc gtg ctc atc tcg ctg      828
 Ala Ala Tyr Val Cys Asn Leu Leu Leu Pro Cys Val Leu Ile Ser Leu
             240                 245                 250

 ctt gcg ccg ctc gcc ttc cac ctg cct gcc gac tca ggc gag aag gtg      876
 Leu Ala Pro Leu Ala Phe His Leu Pro Ala Asp Ser Gly Glu Lys Val
         255                 260                 265

 tcg ctg ggc gtc acc gtg ctg ctg gcg ctc acc gtc ttc cag ttg ctg      924
 Ser Leu Gly Val Thr Val Leu Leu Ala Leu Thr Val Phe Gln Leu Leu
     270                 275                 280

 ctg gcc gag agc atg cca ccg gcc gag agc gtg ccg ctc atc ggg aag      972
 Leu Ala Glu Ser Met Pro Pro Ala Glu Ser Val Pro Leu Ile Gly Lys
 285                 290                 295                 300

 tac tac atg gcc act atg acc atg gtc aca ttc tca aca gca ctc acc     1020
 Tyr Tyr Met Ala Thr Met Thr Met Val Thr Phe Ser Thr Ala Leu Thr
                 305                 310                 315

 atc ctt atc atg aac ctg cat tac tgt ggt ccc agt gtc cgc cca gtg     1068
 Ile Leu Ile Met Asn Leu His Tyr Cys Gly Pro Ser Val Arg Pro Val
             320                 325                 330

 cca gcc tgg gct agg gcc ctc ctg ctg gga cac ctg gca cgg ggc ctg     1116
 Pro Ala Trp Ala Arg Ala Leu Leu Leu Gly His Leu Ala Arg Gly Leu
         335                 340                 345

 tgc gtg cgg gaa aga ggg gag ccc tgt ggg cag tcc agg cca cct gag     1164
 Cys Val Arg Glu Arg Gly Glu Pro Cys Gly Gln Ser Arg Pro Pro Glu
     350                 355                 360

 tta tct cct agc ccc cag tcg cct gaa gga ggg gct ggc ccc cca gcg     1212
 Leu Ser Pro Ser Pro Gln Ser Pro Glu Gly Gly Ala Gly Pro Pro Ala
 365                 370                 375                 380

 ggc cct tgc cac gag cca cga tgt ctg tgc cgc cag gaa gcc cta ctg     1260
 Gly Pro Cys His Glu Pro Arg Cys Leu Cys Arg Gln Glu Ala Leu Leu
                 385                 390                 395

 cac cac gta gcc acc att gcc aat acc ttc cgc agc cac cga gct gcc     1308
 His His Val Ala Thr Ile Ala Asn Thr Phe Arg Ser His Arg Ala Ala
             400                 405                 410

 cag cgc tgc cat gag gac tgg aag cgc ctg gcc cgt gtg atg gac cgc     1356
 Gln Arg Cys His Glu Asp Trp Lys Arg Leu Ala Arg Val Met Asp Arg
         415                 420                 425

 ttc ttc ctg gcc atc ttc ttc tcc atg gcc ctg gtc atg agc ctc ctg     1404
 Phe Phe Leu Ala Ile Phe Phe Ser Met Ala Leu Val Met Ser Leu Leu
     430                 435                 440

 gtg ctg gtg cag gcc ctg tga gg gctgggacta agtcacaggg atctgctgca     1457
 Val Leu Val Gln Ala Leu 
 445                 450

 gccacagctc ctccagaaag ggacagccac ggccaagtgg ttgctggtct ttgggccagc   1517

 cagtctctcc ccactgctcc taagatcctg agacacttga cttcacaatc cacaagggag   1577

 cactcattgt ctacacaccc taactaaagg aagtccagag cctgccactc ccctaattcc   1637

 aaaaaaaaga ggaactctac aaaggccaag atcacagagt acagtcttgg agggacagaa   1697

 ttgtttgtgc tgggtattgg agctctcagt ggggagcaca tgggttataa tgagaaactg   1757

 aactgtactg ctgcatttcc tgtcttcctt cctaggtggc tgctttgcag ggctttggct   1817

 gttacctttc cctgctgagg ggctcaggga aaagggtcgg ggattctcag tcgagtttcc   1877

 agagcaggag gccctacaga catttggccc caaatccctg actcaataaa gtaagcgtgt   1937

 acctagcaaa aaaaaaaaa                                                1956




      <210> 36
      <211> 1255
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1188)

      <400> 36
  atg ggc cgg gcc cgg cgc ttc cag tgg ccg ctg ctg ctg ctg tgg gcg      48
  Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala
    1               5                  10                  15

 gcc gcg gcg ggg cca ggg gca gga cag gaa gta cag aca gag aac gtg       96
 Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val
              20                  25                  30

 aca gtg gct gag ggt ggg gtg gct gag atc acc tgc cgt ctg cac cag      144
 Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln
          35                  40                  45

 tat gat ggg tcc ata gtt gtc atc cag aac cca gcc cgg cag acc ctc      192
 Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu
      50                  55                  60

 ttc ttc aat ggc acc cgt gcc ttg aag gat gag cgt ttc cag ctt gag      240
 Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu
  65                  70                  75                  80

 gag ttc tcc cca cgc cgg gtg cgg atc cgg ctc tca gat gcc cgc ctg      288
 Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu
                  85                  90                  95

 gag gac gag ggg ggc tat ttc tgc cag ctc tac aca gaa gac acc cac      336
 Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His
             100                 105                 110

 cac cag att gcc acg ctc acg gta cta gtg gcc cca gag aat cct gtg      384
 His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val
         115                 120                 125

 gtg gag gtc cgg gag cag gcg gta gag ggc ggc gag gtg gag ctc agc      432
 Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser
     130                 135                 140

 tgc ctc gtt ccg cgg tcc cgt ccg gct gcc acc ctg cgc tgg tac cgg      480
 Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg
 145                 150                 155                 160

 gac cgc aag gag ctg aaa gtg tct gac cgg ggt gtg gca gga gtg agc      528
 Asp Arg Lys Glu Leu Lys Val Ser Asp Arg Gly Val Ala Gly Val Ser
                 165                 170                 175

 agc agc cag gaa aat ggc aag gtc tgg agc gtg gca agc aca gta cgg      576
 Ser Ser Gln Glu Asn Gly Lys Val Trp Ser Val Ala Ser Thr Val Arg
             180                 185                 190

 ttt cgt gtg gac cgt aag gac gac ggt ggt atc atc atc tgt gag gcg      624
 Phe Arg Val Asp Arg Lys Asp Asp Gly Gly Ile Ile Ile Cys Glu Ala
         195                 200                 205

 cag aac cag gcg ctg ccc tcc gga cac agc aag cag acg cag tac gtg      672
 Gln Asn Gln Ala Leu Pro Ser Gly His Ser Lys Gln Thr Gln Tyr Val
     210                 215                 220

 ctg gat gtg cag tac tcc ccc acg gcc cgg att cat gcc tcc caa gct      720
 Leu Asp Val Gln Tyr Ser Pro Thr Ala Arg Ile His Ala Ser Gln Ala
 225                 230                 235                 240

 gtg gtg agg gag gga gac acg ctg gtg ttg acg tgt gct gtc acg ggg      768
 Val Val Arg Glu Gly Asp Thr Leu Val Leu Thr Cys Ala Val Thr Gly
                 245                 250                 255

 aac ccc agg cca aac cag atc cgc tgg aac cgc ggg aat gag tct ttg      816
 Asn Pro Arg Pro Asn Gln Ile Arg Trp Asn Arg Gly Asn Glu Ser Leu
             260                 265                 270

 ccg gag agg gcg gag gcc gtg gga gag acg ctc acg ctg ccg ggt ctg      864
 Pro Glu Arg Ala Glu Ala Val Gly Glu Thr Leu Thr Leu Pro Gly Leu
         275                 280                 285

 gta tcc gcg gat aac ggc acc tac act tgc gag gcg tcc aat aag cac      912
 Val Ser Ala Asp Asn Gly Thr Tyr Thr Cys Glu Ala Ser Asn Lys His
     290                 295                 300

 ggc cat gcg agg gcg ctc tac gta ctt gtg gtc tac gac cct ggt gcg      960
 Gly His Ala Arg Ala Leu Tyr Val Leu Val Val Tyr Asp Pro Gly Ala
 305                 310                 315                 320

 gtg gta gag gct cag acg tcg gtt ccc tat gcc att gtg ggc ggt atc     1008
 Val Val Glu Ala Gln Thr Ser Val Pro Tyr Ala Ile Val Gly Gly Ile
                 325                 330                 335

 ctg gcg ctg ctg gtg ttt ctg atc ata tgt gtg cta gtg ggc atg gtc     1056
 Leu Ala Leu Leu Val Phe Leu Ile Ile Cys Val Leu Val Gly Met Val
             340                 345                 350

 tgg tgc tcg gta cgg cag aag ggt tcc tat ctg acc cac gaa gcc agt     1104
 Trp Cys Ser Val Arg Gln Lys Gly Ser Tyr Leu Thr His Glu Ala Ser
         355                 360                 365

 ggc ttg gat gaa cag gga gaa gta aga gaa gcc ttc ctc aat ggc agc     1152
 Gly Leu Asp Glu Gln Gly Glu Val Arg Glu Ala Phe Leu Asn Gly Ser
     370                 375                 380

 gac gga cac aag agg aaa gag gaa ttc ttc atc tga ccct atccccaccc     1202
 Asp Gly His Lys Arg Lys Glu Glu Phe Phe Ile 
 385                 390                 395

 caggcctagg cctgggcctg ggctggggtc ccccccactg ccagctgcaa gcc          1255




      <210> 37
      <211> 4042
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (911)..(3226)

      <400> 37
 tcacacggta ctctccagca tccactcggt gctggtgaaa gccaggcacg ccctggcgga     60

 gcccagcccc aggtctccat cctccccggc cgcgccccct ccagccccgt ccaggtgcgg    120

 cgtggaccgg tggcgctttg tccgccgggc gcggcgcggg taactgtggc tctggaatag    180

 tgccccgtag tccccgtcga acgaatagcg ctgctgcggc ctcggccggg ccgcggctcc    240

 cccaggaact agagctagag tagggggcgc cgaggttggt ggctccaggg cgccggatcg    300

 gctccttcga gggcccaccg cggcccgaga ctcctccccg gaagtttcct cggatggcag    360

 caggcacagc gaggtggccg agccgcccag agaacgtcca aggaccacct ccggctccgc    420

 ggatgccgtc tcggcctcca tggccttggc ctcgacggcg acggcggggg cagcctggga    480

 ctccacctcg cgcagcgcct cgtagtggtc ctgggccggc agggccgggg cctgtgccgc    540

 gcctgtgcct gcgccgttgg tctgcgagca cacgtggctg acccgcggga gcgacctgga    600

 gcccttgacg cggcggctgt ccccgtcgcc atacacctta tagcggatca tgagcagaac    660

 gatgaagacg aggaccgagg cgacgatgac gcccccgatg gcgatgatca tggtgccgcc    720

 caagaaatgg gccctcagcg ggcggcaggg cgccggatcc ccagcggtgg tgaactgtac    780

 acagcccacc actcgcgttg ccggcagcgc tgtggccccg tcgtcgtaga ccgccagcac    840

 gcacaagtcg taggcacggc ccgccgccag gtcattcacc aggaaggtct gactggtgga    900

 cgggatcatc   atg gct cca gga ccc ttc tcc tcg gcc ctc ctc tcg ccg     949
              Met Ala Pro Gly Pro Phe Ser Ser Ala Leu Leu Ser Pro
                1               5                  10

 ccg ccc gct gcc ctg ccc ttt ctg ctg ctg ctc tgg gcg ggg gca tct      997
 Pro Pro Ala Ala Leu Pro Phe Leu Leu Leu Leu Trp Ala Gly Ala Ser
      15                  20                  25

 cgt ggc cag ccc tgc ccc ggc cgc tgc atc tgc cag aac gtg gcg ccc     1045
 Arg Gly Gln Pro Cys Pro Gly Arg Cys Ile Cys Gln Asn Val Ala Pro
  30                  35                  40                  45

 aca ctg aca atg ctg tgc gcc aag acc ggc ttg ctc ttt gtg ccg ccc     1093
 Thr Leu Thr Met Leu Cys Ala Lys Thr Gly Leu Leu Phe Val Pro Pro
                  50                  55                  60

 gcc atc gac cgg cgc gtg gtg gag ctg cgg ctc acc gac aac ttc atc     1141
 Ala Ile Asp Arg Arg Val Val Glu Leu Arg Leu Thr Asp Asn Phe Ile
              65                  70                  75

 gcc gcc gtg cgc cgc cga gac ttc gcc aac atg acc agc ctg gtg cac     1189
 Ala Ala Val Arg Arg Arg Asp Phe Ala Asn Met Thr Ser Leu Val His
          80                  85                  90

 ctc act ctc tcc cgg aac acc atc ggc cag gtg gca gct ggc gcc ttc     1237
 Leu Thr Leu Ser Arg Asn Thr Ile Gly Gln Val Ala Ala Gly Ala Phe
      95                 100                 105

 gcc gac ctg cgt gcc ctc cgg gcc ctg cac ctg gac agc aac cgc ctg     1285
 Ala Asp Leu Arg Ala Leu Arg Ala Leu His Leu Asp Ser Asn Arg Leu
 110                 115                 120                 125

 gcg gag gtg cgc ggc gac cag ctc cgc ggc ctg ggc aac ctc cgc cac     1333
 Ala Glu Val Arg Gly Asp Gln Leu Arg Gly Leu Gly Asn Leu Arg His
                 130                 135                 140

 ctg atc ctt gga aac aac cag atc cgc cgg gtg gag tcg gcg gcc ttt     1381
 Leu Ile Leu Gly Asn Asn Gln Ile Arg Arg Val Glu Ser Ala Ala Phe
             145                 150                 155

 gac gcc ttc ctg tcc acc gtg gag gac ctg gat ctg tcc tac aac aac     1429
 Asp Ala Phe Leu Ser Thr Val Glu Asp Leu Asp Leu Ser Tyr Asn Asn
         160                 165                 170

 ctg gag gcc ctg ccg tgg gag gcg gtg ggc cag atg gtg aac cta aac     1477
 Leu Glu Ala Leu Pro Trp Glu Ala Val Gly Gln Met Val Asn Leu Asn
     175                 180                 185

 acc ctc acg ctg gac cac aac ctc atc gac cac atc gcg gag ggg acc     1525
 Thr Leu Thr Leu Asp His Asn Leu Ile Asp His Ile Ala Glu Gly Thr
 190                 195                 200                 205

 ttc gtg cag ctt cac aag ctg gtc cgt ctg gac atg acc tcc aac cgc     1573
 Phe Val Gln Leu His Lys Leu Val Arg Leu Asp Met Thr Ser Asn Arg
                 210                 215                 220

 ctg cat aaa ctc ccg ccc gac ggg ctc ttc ctg agg tcg cag ggc acc     1621
 Leu His Lys Leu Pro Pro Asp Gly Leu Phe Leu Arg Ser Gln Gly Thr
             225                 230                 235

 ggg ccc aag ccg ccc acc ccg ctg acc gtc agc ttc ggc ggc aac ccc     1669
 Gly Pro Lys Pro Pro Thr Pro Leu Thr Val Ser Phe Gly Gly Asn Pro
         240                 245                 250

 ctg cac tgc aac tgc gag ctg ctc tgg ctg cgg cgg ctg acc cgc gag     1717
 Leu His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Thr Arg Glu
     255                 260                 265

 gac gac tta gag acc tgc gcc acg ccc gaa cac ctc acc gac cgc tac     1765
 Asp Asp Leu Glu Thr Cys Ala Thr Pro Glu His Leu Thr Asp Arg Tyr
 270                 275                 280                 285

 ttc tgg tcc atc ccc gag gag gag ttc ctg tgt gag ccc ccg ctg atc     1813
 Phe Trp Ser Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu Ile
                 290                 295                 300

 aca cgg cag gcg ggg ggc cgg gcc ctg gtg gtg gaa ggc cag gcg gtg     1861
 Thr Arg Gln Ala Gly Gly Arg Ala Leu Val Val Glu Gly Gln Ala Val
             305                 310                 315

 agc ctg cgc tgc cga gcg gtg ggt gac ccc gag ccg gtg gtg cac tgg     1909
 Ser Leu Arg Cys Arg Ala Val Gly Asp Pro Glu Pro Val Val His Trp
         320                 325                 330

 gtg gca cct gat ggg cgg ctg ctg ggg aac tcc agc cgg acc cgg gtc     1957
 Val Ala Pro Asp Gly Arg Leu Leu Gly Asn Ser Ser Arg Thr Arg Val
     335                 340                 345

 cgg ggg gac ggg acg ctg gat gtg acc atc acc acc ttg agg gac agt     2005
 Arg Gly Asp Gly Thr Leu Asp Val Thr Ile Thr Thr Leu Arg Asp Ser
 350                 355                 360                 365

 ggc acc ttc act tgt atc gcc tcc aat gct gct ggg gaa gcg acg gcg     2053
 Gly Thr Phe Thr Cys Ile Ala Ser Asn Ala Ala Gly Glu Ala Thr Ala
                 370                 375                 380

 ccc gtg gag gtg tgc gtg gta cct ctg cct ctg atg gca ccc ccg ccg     2101
 Pro Val Glu Val Cys Val Val Pro Leu Pro Leu Met Ala Pro Pro Pro
             385                 390                 395

 gct gcc ccg ccg cct ctc acc gag ccc ggc tcc tct gac atc gcc acg     2149
 Ala Ala Pro Pro Pro Leu Thr Glu Pro Gly Ser Ser Asp Ile Ala Thr
         400                 405                 410

 ccg ggc aga cca ggt gcc aac gat tct gcg gct gag cgt cgg ctc gtg     2197
 Pro Gly Arg Pro Gly Ala Asn Asp Ser Ala Ala Glu Arg Arg Leu Val
     415                 420                 425

 gca gcc gag ctc acc tcg aac tcc gtg ctc atc cgc tgg cca gcc cag     2245
 Ala Ala Glu Leu Thr Ser Asn Ser Val Leu Ile Arg Trp Pro Ala Gln
 430                 435                 440                 445

 agg cct gtg ccc gga ata cgc atg tac cag gtt cag tac aac agt tcc     2293
 Arg Pro Val Pro Gly Ile Arg Met Tyr Gln Val Gln Tyr Asn Ser Ser
                 450                 455                 460

 gtt gat gac tcc ctc gtc tac agg atg atc ccg tcc acc agt cag acc     2341
 Val Asp Asp Ser Leu Val Tyr Arg Met Ile Pro Ser Thr Ser Gln Thr
             465                 470                 475

 ttc ctg gtg aat gac ctg gcg gcg ggc cgt gcc tac gac ttg tgc gtg     2389
 Phe Leu Val Asn Asp Leu Ala Ala Gly Arg Ala Tyr Asp Leu Cys Val
         480                 485                 490

 ctg gcg gtc tac gac gac ggg gcc aca gcg ctg ccg gca acg cga gtg     2437
 Leu Ala Val Tyr Asp Asp Gly Ala Thr Ala Leu Pro Ala Thr Arg Val
     495                 500                 505

 gtg ggc tgt gta cag ttc acc acc gct ggg gat ccg gcg ccc tgc cgc     2485
 Val Gly Cys Val Gln Phe Thr Thr Ala Gly Asp Pro Ala Pro Cys Arg
 510                 515                 520                 525

 ccg ctg agg gcc cat ttc ttg ggc ggc acc atg atc atc gcc atc ggg     2533
 Pro Leu Arg Ala His Phe Leu Gly Gly Thr Met Ile Ile Ala Ile Gly
                 530                 535                 540

 ggc gtc atc gtc gcc tcg gtc ctc gtc ttc atc gtt ctg ctc atg atc     2581
 Gly Val Ile Val Ala Ser Val Leu Val Phe Ile Val Leu Leu Met Ile
             545                 550                 555

 cgc tat aag gtg tat ggc gac ggg gac agc cgc cgc gtc aag ggc tcc     2629
 Arg Tyr Lys Val Tyr Gly Asp Gly Asp Ser Arg Arg Val Lys Gly Ser
         560                 565                 570

 agg tcg ctc ccg cgg gtc agc cac gtg tgc tcg cag acc aac ggc gca     2677
 Arg Ser Leu Pro Arg Val Ser His Val Cys Ser Gln Thr Asn Gly Ala
     575                 580                 585

 ggc aca ggc gcg gca cag gcc ccg gcc ctg ccg gcc cag gac cac tac     2725
 Gly Thr Gly Ala Ala Gln Ala Pro Ala Leu Pro Ala Gln Asp His Tyr
 590                 595                 600                 605

 gag gcg ctg cgc gag gtg gag tcc cag gct gcc ccc gcc gtc gcc gtc     2773
 Glu Ala Leu Arg Glu Val Glu Ser Gln Ala Ala Pro Ala Val Ala Val
                 610                 615                 620

 gag gcc aag gcc atg gag gcc gag acg gca tcc gcg gag ccg gag gtg     2821
 Glu Ala Lys Ala Met Glu Ala Glu Thr Ala Ser Ala Glu Pro Glu Val
             625                 630                 635

 gtc ctt gga cgt tct ctg ggc ggc tcg gcc acc tcg ctg tgc ctg ctg     2869
 Val Leu Gly Arg Ser Leu Gly Gly Ser Ala Thr Ser Leu Cys Leu Leu
         640                 645                 650

 cca tcc gag gaa act tcc ggg gag gag tct cgg gcc gcg gtg ggc cct     2917
 Pro Ser Glu Glu Thr Ser Gly Glu Glu Ser Arg Ala Ala Val Gly Pro
     655                 660                 665

 cga agg agc cga tcc ggc gcc ctg gag cca cca acc tcg gcg ccc cct     2965
 Arg Arg Ser Arg Ser Gly Ala Leu Glu Pro Pro Thr Ser Ala Pro Pro
 670                 675                 680                 685

 act cta gct cta gtt cct ggg gga gcc gcg gcc cgg ccg agg ccg cag     3013
 Thr Leu Ala Leu Val Pro Gly Gly Ala Ala Ala Arg Pro Arg Pro Gln
                 690                 695                 700

 cag cgc tat tcg ttc gac ggg gac tac ggg gca cta ttc cag agc cac     3061
 Gln Arg Tyr Ser Phe Asp Gly Asp Tyr Gly Ala Leu Phe Gln Ser His
             705                 710                 715

 agt tac ccg cgc cgc gcc cgg cgg aca aag cgc cac cgg tcc acg ccg     3109
 Ser Tyr Pro Arg Arg Ala Arg Arg Thr Lys Arg His Arg Ser Thr Pro
         720                 725                 730

 cac ctg gac ggg gct gga ggg ggc gcg gcc ggg gag gat gga gac ctg     3157
 His Leu Asp Gly Ala Gly Gly Gly Ala Ala Gly Glu Asp Gly Asp Leu
     735                 740                 745

 ggg ctg ggc tcc gcc agg gcg tgc ctg gct ttc acc agc acc gag tgg     3205
 Gly Leu Gly Ser Ala Arg Ala Cys Leu Ala Phe Thr Ser Thr Glu Trp
 750                 755                 760                 765

 atg ctg gag agt acc gtg tga gc ggcgggcggg cgccgggacg cctgggtgcc     3258
 Met Leu Glu Ser Thr Val 
                 770

 gcagaccaaa cgcccagccg cacggacgct ggggcgggac tgggagaaag cgcagcgcca   3318

 agacattgga ccagagtgga gacgcgccct tgtccccggg agggggcggg gcagcctcgg   3378

 gctgcggctc gaggccacgc ccccgtgccc agggcggggt tcggggaccg gctgccggcc   3438

 tcccttcccc tatggactcc tcgacccccc tcctacccct cccctcgcgc gctcgcggac   3498

 ctcgctggag ccggtgcctt acacagcgaa gcgcggggag gggcagggcc ccctgacact   3558

 gcagcactga gacacgagcc ccctccccca gcccgtcacc cggggccggg gcgaggggcc   3618

 catttcttgt atctggctgg actagatcct attctgtccc gcggcggcct ccaaagcctc   3678

 ccaccccacc ccacgcacat tcctggtccg gtcgggtctg gcttggggtc cccctttctc   3738

 tgtttccctc gtttgtctct atcccgccct cttgtcgtct ctctgtagtg cctgtctttc   3798

 cctatttgcc tctcctttct ctctgtcctg tcgtctcttg tccctcggcc ctccctggtt   3858

 ttgtctagtc tccctgtctc tcctgatttc ttctctttac tcattctccc gggcaggtcc   3918

 cactggaagg accagactct cccaaataaa tccccacacg aacaaaatcc aaaaccaaat   3978

 ccccctccct accggagccg ggaccctccg ccgcagcaga attaaacttt tttctgtgtc   4038

 tgag                                                                4042




      <210> 38
      <211> 2241
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(1523)

      <400> 38
 ggcaggtccg ggcacccacc    atg cga ggc gag ctc tgg ctc ctg gtg ctg      50
                          Met Arg Gly Glu Leu Trp Leu Leu Val Leu
                            1               5                  10

 gtg ctc agg gag gct gcc cgg gcg ctg agc ccc cag ccc gga gca ggt       98
 Val Leu Arg Glu Ala Ala Arg Ala Leu Ser Pro Gln Pro Gly Ala Gly
                  15                  20                  25

 cac gat gag ggc cca ggc tct gga tgg gct gcc aaa ggg acc gtg cgg      146
 His Asp Glu Gly Pro Gly Ser Gly Trp Ala Ala Lys Gly Thr Val Arg
              30                  35                  40

 ggc tgg aac cgg aga gcc cga gag agc cct ggg cat gtg tca gag ccg      194
 Gly Trp Asn Arg Arg Ala Arg Glu Ser Pro Gly His Val Ser Glu Pro
          45                  50                  55

 gac agg acc cag ctg agc cag gac ctg ggt ggg ggc acc ctg gcc atg      242
 Asp Arg Thr Gln Leu Ser Gln Asp Leu Gly Gly Gly Thr Leu Ala Met
      60                  65                  70

 gac acg ctg cca gat aac agg acc agg gtg gtg gag gac aac cac agc      290
 Asp Thr Leu Pro Asp Asn Arg Thr Arg Val Val Glu Asp Asn His Ser
  75                  80                  85                  90

 tat tat gtg tcc cgt ctc tat ggc ccc agc gag ccc cac agc cgg gaa      338
 Tyr Tyr Val Ser Arg Leu Tyr Gly Pro Ser Glu Pro His Ser Arg Glu
                  95                 100                 105

 ctg tgg gta gat gtg gcc gag gcc aac cgg agc caa gtg aag atc cac      386
 Leu Trp Val Asp Val Ala Glu Ala Asn Arg Ser Gln Val Lys Ile His
             110                 115                 120

 aca ata ctc tcc aac acc cac cgg cag gct tcg aga gtg gtc ttg tcc      434
 Thr Ile Leu Ser Asn Thr His Arg Gln Ala Ser Arg Val Val Leu Ser
         125                 130                 135

 ttt gat ttc cct ttc tac ggg cat cct ctg cgg cag atc acc ata gca      482
 Phe Asp Phe Pro Phe Tyr Gly His Pro Leu Arg Gln Ile Thr Ile Ala
     140                 145                 150

 act gga ggc ttc atc ttc atg ggg gac gtg atc cat cgg atg ctc aca      530
 Thr Gly Gly Phe Ile Phe Met Gly Asp Val Ile His Arg Met Leu Thr
 155                 160                 165                 170

 gct act cag tat gtg gcg ccc ctg atg gcc aac ttc aac cct ggc tac      578
 Ala Thr Gln Tyr Val Ala Pro Leu Met Ala Asn Phe Asn Pro Gly Tyr
                 175                 180                 185

 tcc gac aac tcc aca gtt gtt tac ttt gac aat ggg aca gtc ttt gtg      626
 Ser Asp Asn Ser Thr Val Val Tyr Phe Asp Asn Gly Thr Val Phe Val
             190                 195                 200

 gtt cag tgg gac cac gtt tat ctc caa ggc tgg gaa gac aag ggc agt      674
 Val Gln Trp Asp His Val Tyr Leu Gln Gly Trp Glu Asp Lys Gly Ser
         205                 210                 215

 ttc acc ttc cag gca gct ctg cac cat gac ggc cgc att gtc ttt gcc      722
 Phe Thr Phe Gln Ala Ala Leu His His Asp Gly Arg Ile Val Phe Ala
     220                 225                 230

 tat aaa gag atc cct atg tct gtc ccg gaa atc agc tcc tcc cag cat      770
 Tyr Lys Glu Ile Pro Met Ser Val Pro Glu Ile Ser Ser Ser Gln His
 235                 240                 245                 250

 cct gtc aaa acc ggc cta tcg gat gcc ttc atg att ctc aat cca tcc      818
 Pro Val Lys Thr Gly Leu Ser Asp Ala Phe Met Ile Leu Asn Pro Ser
                 255                 260                 265

 ccg gat gtg cca gaa tct cgg cga agg agc atc ttt gaa tat cac cgc      866
 Pro Asp Val Pro Glu Ser Arg Arg Arg Ser Ile Phe Glu Tyr His Arg
             270                 275                 280

 ata gag ctg gac ccc agc aag gtc acc agc atg tcg gcc gtg gag ttc      914
 Ile Glu Leu Asp Pro Ser Lys Val Thr Ser Met Ser Ala Val Glu Phe
         285                 290                 295

 acc cca ttg ccg acc tgc ctg cag cat agg agc tgt gac gcc tgc atg      962
 Thr Pro Leu Pro Thr Cys Leu Gln His Arg Ser Cys Asp Ala Cys Met
     300                 305                 310

 tcc tca gac ctg acc ttc aac tgc agc tgg tgc cat gtc ctc cag aga     1010
 Ser Ser Asp Leu Thr Phe Asn Cys Ser Trp Cys His Val Leu Gln Arg
 315                 320                 325                 330

 tgc tcc agt ggc ttt gac cgc tat cgc cag gag tgg atg gac tat ggc     1058
 Cys Ser Ser Gly Phe Asp Arg Tyr Arg Gln Glu Trp Met Asp Tyr Gly
                 335                 340                 345

 tgt gca cag gag gca gag ggc agg atg tgc gag gac ttc cag gat gag     1106
 Cys Ala Gln Glu Ala Glu Gly Arg Met Cys Glu Asp Phe Gln Asp Glu
             350                 355                 360

 gac cac gac tca gcc tcc cct gac act tcc ttc agc ccc tat gat gga     1154
 Asp His Asp Ser Ala Ser Pro Asp Thr Ser Phe Ser Pro Tyr Asp Gly
         365                 370                 375

 gac ctc acc act acc tcc tcc tcc ctc ttc atc gac agc ctc acc aca     1202
 Asp Leu Thr Thr Thr Ser Ser Ser Leu Phe Ile Asp Ser Leu Thr Thr
     380                 385                 390

 gaa gat gac acc aag ttg aat ccc tat gca gga gga gac ggc ctt cag     1250
 Glu Asp Asp Thr Lys Leu Asn Pro Tyr Ala Gly Gly Asp Gly Leu Gln
 395                 400                 405                 410

 aac aac ctg tcc ccc aag aca aag ggc act cct gtg cac ctg ggc acc     1298
 Asn Asn Leu Ser Pro Lys Thr Lys Gly Thr Pro Val His Leu Gly Thr
                 415                 420                 425

 atc gtg ggc atc gtg ctg gca gtc ctc ctc gtg gcg gcc atc atc ctg     1346
 Ile Val Gly Ile Val Leu Ala Val Leu Leu Val Ala Ala Ile Ile Leu
             430                 435                 440

 gct gga att tac atc aat ggc cac ccc aca tcc aat gct gcg ctc ttc     1394
 Ala Gly Ile Tyr Ile Asn Gly His Pro Thr Ser Asn Ala Ala Leu Phe
         445                 450                 455

 ttc atc gag cgt aga cct cac cac tgg cca gcc atg aag ttt cgc agc     1442
 Phe Ile Glu Arg Arg Pro His His Trp Pro Ala Met Lys Phe Arg Ser
     460                 465                 470

 cac cct gac cat tcc acc tat gcg gag gtg gag ccc tcg ggc cat gag     1490
 His Pro Asp His Ser Thr Tyr Ala Glu Val Glu Pro Ser Gly His Glu
 475                 480                 485                 490

 aag gag ggc ttc atg gag gct gag cag tgc tga gaacacca agtctcccct     1541
 Lys Glu Gly Phe Met Glu Ala Glu Gln Cys 
                 495                 500

 ttgaagactt tgaggccaca gaaaagacag ttaaagcaaa gaagagaagt gacttttcct   1601

 ggcctctccc agcatgccct gggctgagat gagatggtgg tttatggctc cagagctgct   1661

 gctcgcttcg tcagcacacc ccgaatattg aagagggggc caaaaaacaa ccacatggat   1721

 tttttatagg aacaacaacc taatctcatc ctgttttgat gcaagggttc tcttctgtgt   1781

 cttgtaacca tgaaacagca gaagaactaa cataactaac tccattttta tttaaggggc   1841

 ctttacctat tcctgcacct aggctaggat aactttagag cactgacata aaacgcaaaa   1901

 acaggaatca tgccgtttgc aaaactaact ctgggattaa aggggaagca tgtaaacagc   1961

 taactgtttt tgttaaagat ttataggaat gaggaggttt ggctattgtc acatgacaga   2021

 ctgttagcca aggacaaaga agttctgcaa acctcccctg gacccttgct ggtgtccaga   2081

 tgtctgcggt tgtcagcccc ttcctttccc ccgacctaaa cataaaagac aaggcaaagc   2141

 ccgcataatt ttaagacggt tctttaggac attagtccac catcttcttg gtttgctggc   2201

 tctccgaaat aaagtccctt tccttgctcc aaaaaaaaaa                         2241




      <210> 39
      <211> 2205
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(1487)

      <400> 39
 ggcaggtccg ggcacccacc    atg cga ggc gag ctc tgg ctc ctg gtg ctg      50
                          Met Arg Gly Glu Leu Trp Leu Leu Val Leu
                            1               5                  10

 gtg ctc agg gag gct gcc cgg gcg ctg agc ccc cag ccc gga gca ggt       98
 Val Leu Arg Glu Ala Ala Arg Ala Leu Ser Pro Gln Pro Gly Ala Gly
                  15                  20                  25

 cac gat gag ggc cca ggc tct gga tgg gct gcc aaa ggg acc gtg cgg      146
 His Asp Glu Gly Pro Gly Ser Gly Trp Ala Ala Lys Gly Thr Val Arg
              30                  35                  40

 ggc tgg aac cgg aga gcc cga gag agc cct ggg cat gtg tca gag ccg      194
 Gly Trp Asn Arg Arg Ala Arg Glu Ser Pro Gly His Val Ser Glu Pro
          45                  50                  55

 gac agg acc cag ctg agc cag gac ctg ggt ggg ggc acc ctg gcc atg      242
 Asp Arg Thr Gln Leu Ser Gln Asp Leu Gly Gly Gly Thr Leu Ala Met
      60                  65                  70

 gac acg ctg cca gat aac agg acc agg gtg gtg gag gac aac cac agc      290
 Asp Thr Leu Pro Asp Asn Arg Thr Arg Val Val Glu Asp Asn His Ser
  75                  80                  85                  90

 tat tat gtg tcc cgt ctc tat ggc ccc agc gag ccc cac agc cgg gaa      338
 Tyr Tyr Val Ser Arg Leu Tyr Gly Pro Ser Glu Pro His Ser Arg Glu
                  95                 100                 105

 ctg tgg gta gat gtg gcc gag gcc aac cgg agc caa gtg aag atc cac      386
 Leu Trp Val Asp Val Ala Glu Ala Asn Arg Ser Gln Val Lys Ile His
             110                 115                 120

 aca ata ctc tcc aac acc cac cgg cag gct tcg aga gtg gtc ttg tcc      434
 Thr Ile Leu Ser Asn Thr His Arg Gln Ala Ser Arg Val Val Leu Ser
         125                 130                 135

 ttt gat ttc cct ttc tac ggg cat cct ctg cgg cag atc acc ata gca      482
 Phe Asp Phe Pro Phe Tyr Gly His Pro Leu Arg Gln Ile Thr Ile Ala
     140                 145                 150

 act gga ggc ttc atc ttc atg ggg gac gtg atc cat cgg atg ctc aca      530
 Thr Gly Gly Phe Ile Phe Met Gly Asp Val Ile His Arg Met Leu Thr
 155                 160                 165                 170

 gct act cag tat gtg gcg ccc ctg atg gcc aac ttc aac cct ggc tac      578
 Ala Thr Gln Tyr Val Ala Pro Leu Met Ala Asn Phe Asn Pro Gly Tyr
                 175                 180                 185

 tcc gac aac tcc aca gtt gtt tac ttt gac aat ggg aca gtc ttt gtg      626
 Ser Asp Asn Ser Thr Val Val Tyr Phe Asp Asn Gly Thr Val Phe Val
             190                 195                 200

 gtt cag tgg gac cac gtt tat ctc caa ggc tgg gaa gac aag ggc agt      674
 Val Gln Trp Asp His Val Tyr Leu Gln Gly Trp Glu Asp Lys Gly Ser
         205                 210                 215

 ttc acc ttc cag gca gct ctg cac cat gac ggc cgc att gtc ttt gcc      722
 Phe Thr Phe Gln Ala Ala Leu His His Asp Gly Arg Ile Val Phe Ala
     220                 225                 230

 tat aaa gag atc cct atg tct gtc ccg gaa atc agc tcc tcc cag cat      770
 Tyr Lys Glu Ile Pro Met Ser Val Pro Glu Ile Ser Ser Ser Gln His
 235                 240                 245                 250

 cct gtc aaa acc ggc cta tcg gat gcc ttc atg att ctc aat cca tcc      818
 Pro Val Lys Thr Gly Leu Ser Asp Ala Phe Met Ile Leu Asn Pro Ser
                 255                 260                 265

 ccg gat gtg cca gaa tct cgg cga agg agc atc ttt gaa tat cac cgc      866
 Pro Asp Val Pro Glu Ser Arg Arg Arg Ser Ile Phe Glu Tyr His Arg
             270                 275                 280

 ata gag ctg gac ccc agc aag gtc acc agc atg tcg gcc gtg gag ttc      914
 Ile Glu Leu Asp Pro Ser Lys Val Thr Ser Met Ser Ala Val Glu Phe
         285                 290                 295

 acc cca ttg ccg acc tgc ctg cag cat agg agc tgt gac gcc tgc atg      962
 Thr Pro Leu Pro Thr Cys Leu Gln His Arg Ser Cys Asp Ala Cys Met
     300                 305                 310

 tcc tca gac ctg acc ttc aac tgc agc tgg tgc cat gtc ctc cag aga     1010
 Ser Ser Asp Leu Thr Phe Asn Cys Ser Trp Cys His Val Leu Gln Arg
 315                 320                 325                 330

 tgc tcc agt ggc ttt gac cgc tat cgc cag gag tgg atg gac tat ggc     1058
 Cys Ser Ser Gly Phe Asp Arg Tyr Arg Gln Glu Trp Met Asp Tyr Gly
                 335                 340                 345

 tgt gca cag gag gca gag ggc agg atg tgc gag gac ttc cag gat gag     1106
 Cys Ala Gln Glu Ala Glu Gly Arg Met Cys Glu Asp Phe Gln Asp Glu
             350                 355                 360

 gac cac gac tca gcc tcc cct gac act tcc ttc agc ccc tat gat gga     1154
 Asp His Asp Ser Ala Ser Pro Asp Thr Ser Phe Ser Pro Tyr Asp Gly
         365                 370                 375

 gac ctc acc act acc tcc tcc tcc ctc ttc atc gac agc ctc acc aca     1202
 Asp Leu Thr Thr Thr Ser Ser Ser Leu Phe Ile Asp Ser Leu Thr Thr
     380                 385                 390

 gaa ggc ctt cag aac aac ctg tcc ccc aag aca aag ggc act cct gtg     1250
 Glu Gly Leu Gln Asn Asn Leu Ser Pro Lys Thr Lys Gly Thr Pro Val
 395                 400                 405                 410

 cac ctg ggc acc atc gtg ggc atc gtg ctg gca gtc ctc ctc gtg gcg     1298
 His Leu Gly Thr Ile Val Gly Ile Val Leu Ala Val Leu Leu Val Ala
                 415                 420                 425

 gcc atc atc ctg gct gga att tac atc aat ggc cac ccc aca tcc aat     1346
 Ala Ile Ile Leu Ala Gly Ile Tyr Ile Asn Gly His Pro Thr Ser Asn
             430                 435                 440

 gct gcg ctc ttc ttc atc gag cgt aga cct cac cac tgg cca gcc atg     1394
 Ala Ala Leu Phe Phe Ile Glu Arg Arg Pro His His Trp Pro Ala Met
         445                 450                 455

 aag ttt cgc agc cac cct gac cat tcc acc tat gcg gag gtg gag ccc     1442
 Lys Phe Arg Ser His Pro Asp His Ser Thr Tyr Ala Glu Val Glu Pro
     460                 465                 470

 tcg ggc cat gag aag gag ggc ttc atg gag gct gag cag tgc tga gaa     1490
 Ser Gly His Glu Lys Glu Gly Phe Met Glu Ala Glu Gln Cys 
 475                 480                 485

 caccaagtct cccctttgaa gactttgagg ccacagaaaa gacagttaaa gcaaagaaga   1550

 gaagtgactt ttcctggcct ctcccagcat gccctgggct gagatgagat ggtggtttat   1610

 ggctccagag ctgctgctcg cttcgtcagc acaccccgaa tattgaagag ggggccaaaa   1670

 aacaaccaca tggatttttt ataggaacaa caacctaatc tcatcctgtt ttgatgcaag   1730

 ggttctcttc tgtgtcttgt aaccatgaaa cagcagaaga actaacataa ctaactccat   1790

 ttttatttaa ggggccttta cctattcctg cacctaggct aggataactt tagagcactg   1850

 acataaaacg caaaaacagg aatcatgccg tttgcaaaac taactctggg attaaagggg   1910

 aagcatgtaa acagctaact gtttttgtta aagatttata ggaatgagga ggtttggcta   1970

 ttgtcacatg acagactgtt agccaaggac aaagaagttc tgcaaacctc ccctggaccc   2030

 ttgctggtgt ccagatgtct gcggttgtca gccccttcct ttcccccgac ctaaacataa   2090

 aagacaaggc aaagcccgca taattttaag acggttcttt aggacattag tccaccatct   2150

 tcttggtttg ctggctctcc gaaataaagt ccctttcctt gctccaaaaa aaaaa        2205




      <210> 40
      <211> 861
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(861)

      <400> 40
  atg ggg gcc atc aag ctc agc cac aac ctt cac act cct atg tac ttt      48
  Met Gly Ala Ile Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe
    1               5                  10                  15

 ttc ctc tgt ggc ctg tcc ttt tca gaa act tgt acc act gtg gta gta       96
 Phe Leu Cys Gly Leu Ser Phe Ser Glu Thr Cys Thr Thr Val Val Val
              20                  25                  30

 atc cct cgc atg ttg gtg gac ttt cta tca gag agc aag acc att tct      144
 Ile Pro Arg Met Leu Val Asp Phe Leu Ser Glu Ser Lys Thr Ile Ser
          35                  40                  45

 ctt cct gag tgt gcc aca cag atg ttt ttc ttt ctg ggc ttt gca tcc      192
 Leu Pro Glu Cys Ala Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Ser
      50                  55                  60

 aac aac tgt ttc atc atg gcc gct atg tcc tac gac cgc tac acg gcc      240
 Asn Asn Cys Phe Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala
  65                  70                  75                  80

 atc cac aac cca ctg cag tac cac acc ctt atg aca aga aag atc tgc      288
 Ile His Asn Pro Leu Gln Tyr His Thr Leu Met Thr Arg Lys Ile Cys
                  85                  90                  95

 ttg cag atg atg atg gct tct tgg atg gtt ggg ttc ctg ttt tct ctg      336
 Leu Gln Met Met Met Ala Ser Trp Met Val Gly Phe Leu Phe Ser Leu
             100                 105                 110

 tgc atc atc gtc act gta ttc aac ttg tct ctt tgc gac ttg aac act      384
 Cys Ile Ile Val Thr Val Phe Asn Leu Ser Leu Cys Asp Leu Asn Thr
         115                 120                 125

 atc cag cac tat ttc tgt gat atc tca cca gtg gtc tcc ctt gct tgt      432
 Ile Gln His Tyr Phe Cys Asp Ile Ser Pro Val Val Ser Leu Ala Cys
     130                 135                 140

 aat tac act ttc tat cat gaa atg gct att ttt gtg ctc tct gcc ttt      480
 Asn Tyr Thr Phe Tyr His Glu Met Ala Ile Phe Val Leu Ser Ala Phe
 145                 150                 155                 160

 gtg ttg gtg ggc agc tgt att tta att atg att tcc tat gtc ttc att      528
 Val Leu Val Gly Ser Cys Ile Leu Ile Met Ile Ser Tyr Val Phe Ile
                 165                 170                 175

 gtg ttc ata gtc ata aag atg ccc tct gca aag ggg agg tct aag gcc      576
 Val Phe Ile Val Ile Lys Met Pro Ser Ala Lys Gly Arg Ser Lys Ala
             180                 185                 190

 ttc tca act tgc tcc tcc cac ctc act gtt gtg tcc ata cac tat gga      624
 Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ser Ile His Tyr Gly
         195                 200                 205

 ttt gct tgc ttt gtc tat ttg agg ccc aag aac agc aac tcc ttc gat      672
 Phe Ala Cys Phe Val Tyr Leu Arg Pro Lys Asn Ser Asn Ser Phe Asp
     210                 215                 220

 gaa gac atg ctg acg gcc atg ata tat aca ata ctg atg cct ctg ctt      720
 Glu Asp Met Leu Thr Ala Met Ile Tyr Thr Ile Leu Met Pro Leu Leu
 225                 230                 235                 240

 aac ccc atc gtg tac agt ctg aga aac aaa gaa atg cag ata gcc cta      768
 Asn Pro Ile Val Tyr Ser Leu Arg Asn Lys Glu Met Gln Ile Ala Leu
                 245                 250                 255

 aga aaa aca cta ggc agt gta ttt ggg gtt ttc cct cag aag aca aaa      816
 Arg Lys Thr Leu Gly Ser Val Phe Gly Val Phe Pro Gln Lys Thr Lys
             260                 265                 270

 aaa gag cct gaa cat tta aaa aaa tta cac agc att gat aaa taa          861
 Lys Glu Pro Glu His Leu Lys Lys Leu His Ser Ile Asp Lys 
         275                 280                 285





      <210> 41
      <211> 1916
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(1873)

      <400> 41
 tttctttgaa gaaaaatgtg cttcttgaat caactgcagt ctctcctctg cataagagct     60

 cttaagggta ctagcaggat agaagcaaat gaaactgaaa gctcatctgc agctcagaaa    120

 agcaaagaca tggaatttta aagagtgaag gtagcatggt gtcggccatg ggtgaacaag    180

 acacagccag aca   atg tgg acc aat ttc ttc aaa cta cgg ctt ttc tgc     229
                  Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys
                    1               5                  10

 tgt ctg ctt gca gtg ttg atg gtg gtg gtg ctg gtc atc aat gtt act      277
 Cys Leu Leu Ala Val Leu Met Val Val Val Leu Val Ile Asn Val Thr
          15                  20                  25

 cag gta gag tac ttg gac cat gag act gtt tca gcc act ttc atc gac      325
 Gln Val Glu Tyr Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp
      30                  35                  40

 agc agt gga cag ttt gtt tcc tcc cag gtg aca gga att agc cga aat      373
 Ser Ser Gly Gln Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn
  45                  50                  55                  60

 ccc tac tgt ggc tat gat cag cag acc ctg tcc agc cag gag cgc atg      421
 Pro Tyr Cys Gly Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met
                  65                  70                  75

 gag gag gac tcc ttg ctg gct gcc ttg cac cgg cag gtt cct gat gtg      469
 Glu Glu Asp Ser Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val
              80                  85                  90

 ggc cca gtc ccc ttt gtg aag agc act gac cct tct tcc agc tac ttt      517
 Gly Pro Val Pro Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe
          95                 100                 105

 gtc atc ttg aac tct gct gcc ttc ttt aag gtg gga agc cag ctt gag      565
 Val Ile Leu Asn Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu
     110                 115                 120

 gtg ctg gtt cat gtg cag gat ttt caa aga aag ccc aag aag tat ggt      613
 Val Leu Val His Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly
 125                 130                 135                 140

 gga gac tac ctg cag gcc aga att cac tcc ctc aag ctg cag gct ggg      661
 Gly Asp Tyr Leu Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly
                 145                 150                 155

 gct gtg ggc agg gtg gtg gat tac cag aat ggg ttt tac aag gtt ttc      709
 Ala Val Gly Arg Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe
             160                 165                 170

 ttt act ttg cta tgg cca ggc aaa gtt aaa gta tcc gta tct ctg gtc      757
 Phe Thr Leu Leu Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val
         175                 180                 185

 cac ccc agt gaa ggg atc aga gtt ctt cag cgc tta cag gaa gat aaa      805
 His Pro Ser Glu Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys
     190                 195                 200

 cca gac agg gtc tat ttc aag agt ctc ttc cgt tca gga aga att tct      853
 Pro Asp Arg Val Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser
 205                 210                 215                 220

 gaa act act gag tgc aac gtg tgt ctt cct ggg aat ctg ccc ctg tgt      901
 Glu Thr Thr Glu Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys
                 225                 230                 235

 aac ttt aca gac ctc tac act ggg gag ccc tgg ttc tgc ttc aaa cca      949
 Asn Phe Thr Asp Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro
             240                 245                 250

 aag aag ctc cct tgc agc agc aga att acc cat ttc aaa ggt gga tac      997
 Lys Lys Leu Pro Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr
         255                 260                 265

 ctg aaa ggt ctc cta acc gct gca gag agt gct ttc ttc cag agt ggt     1045
 Leu Lys Gly Leu Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly
     270                 275                 280

 gtc aat atc aaa atg cca gtc aac tcc agt gga cct gat tgg gta act     1093
 Val Asn Ile Lys Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr
 285                 290                 295                 300

 gtg att ccc agg aga ata aaa gaa act aac agt cta gaa cta tct caa     1141
 Val Ile Pro Arg Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln
                 305                 310                 315

 ggc tca gga act ttt cct tct ggg tat tat tat aaa gac cag tgg agg     1189
 Gly Ser Gly Thr Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg
             320                 325                 330

 ccc aga aag ttt aag atg cgt cag ttt aat gac cct gac aac att aca     1237
 Pro Arg Lys Phe Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr
         335                 340                 345

 gag tgc tta caa aga aaa gtg gtg cat tta ttt ggt gac tca aca atc     1285
 Glu Cys Leu Gln Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile
     350                 355                 360

 agg caa tgg ttt gaa tac ctt act aca ttt gtt cca gat tta gtg gag     1333
 Arg Gln Trp Phe Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu
 365                 370                 375                 380

 ttt aac ttg ggt agt ccc aag aat gtg ggt ccc ttc ctt gca gtg gac     1381
 Phe Asn Leu Gly Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp
                 385                 390                 395

 cag aag cac aac atc ctg ctc aaa tac cgc tgc cat ggt cca ccc atc     1429
 Gln Lys His Asn Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile
             400                 405                 410

 cgc ttc acg act gtc ttt agc aat gag ctc cat tat gtg gcg aat gag     1477
 Arg Phe Thr Thr Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu
         415                 420                 425

 ctg aat ggc att gtg gga ggg aag aac aca gtg gtt gcc ata gct gta     1525
 Leu Asn Gly Ile Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val
     430                 435                 440

 tgg tct cac ttc agc acc ttc cct ttg gaa gtg tac atc cgg cgg ctc     1573
 Trp Ser His Phe Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu
 445                 450                 455                 460

 agg aac atc cgt cga gca gtg gtt cgg ctc ctc gat cga agc cca aag     1621
 Arg Asn Ile Arg Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys
                 465                 470                 475

 acc gtg gtg gtc atc cgg acg gcc aac gcc caa gag ctg gga cct gag     1669
 Thr Val Val Val Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu
             480                 485                 490

 gtg agc ctt ttc aac agc gac tgg tac aac ttt cag ctg gac acc atc     1717
 Val Ser Leu Phe Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile
         495                 500                 505

 ctt cgg agg atg ttc tca ggg gtt gga gta tat ctc gtc gat gcc tgg     1765
 Leu Arg Arg Met Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp
     510                 515                 520

 gag atg acc ctg gcc cat tat cta ccg cac aag ctg cat cca gat gaa     1813
 Glu Met Thr Leu Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu
 525                 530                 535                 540

 gtt att gtg aag aac cag ctg gac atg ttc ttg tcc ttt gtg tgc ccc     1861
 Val Ile Val Lys Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro
                 545                 550                 555

 ttg gaa acc tag cct gtcttggaag ggactggagg aatcatattc aatgaccttc     1916
 Leu Glu Thr 






      <210> 42
      <211> 1643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1308)

      <400> 42
  atg gcg gct ccc ttg gtc ctg gtg ctg gtg gtg gct gtg aca gtg cgg      48
  Met Ala Ala Pro Leu Val Leu Val Leu Val Val Ala Val Thr Val Arg
    1               5                  10                  15

 gcg gcc ttg ttc cgc tcc agt ctg gcc gag ttc att tcc gag cgg gtg       96
 Ala Ala Leu Phe Arg Ser Ser Leu Ala Glu Phe Ile Ser Glu Arg Val
              20                  25                  30

 gag gtg gtg tcc cca ctg agc tct tgg aag aga gtg gtt gaa ggc ctt      144
 Glu Val Val Ser Pro Leu Ser Ser Trp Lys Arg Val Val Glu Gly Leu
          35                  40                  45

 tca ctg ttg gac ttg gga gta tct ccg tat tct gga gca gta ttt cat      192
 Ser Leu Leu Asp Leu Gly Val Ser Pro Tyr Ser Gly Ala Val Phe His
      50                  55                  60

 gaa act cca tta ata ata tac ctc ttt cat ttc cta att gac tat gct      240
 Glu Thr Pro Leu Ile Ile Tyr Leu Phe His Phe Leu Ile Asp Tyr Ala
  65                  70                  75                  80

 gaa ttg gtg ttt atg ata act gat gca ctc act gct att gcc ctg tat      288
 Glu Leu Val Phe Met Ile Thr Asp Ala Leu Thr Ala Ile Ala Leu Tyr
                  85                  90                  95

 ttt gca atc cag gac ttc aat aaa gtt gtg ttt aaa aag cag aaa ctc      336
 Phe Ala Ile Gln Asp Phe Asn Lys Val Val Phe Lys Lys Gln Lys Leu
             100                 105                 110

 ctc cta gaa ctg gac cag tat gcc cca gat gtg gcc gaa ctc atc cgg      384
 Leu Leu Glu Leu Asp Gln Tyr Ala Pro Asp Val Ala Glu Leu Ile Arg
         115                 120                 125

 acc cct atg gaa atg cgt tac atc cct ttg aaa gtg gcc ctg ttc tat      432
 Thr Pro Met Glu Met Arg Tyr Ile Pro Leu Lys Val Ala Leu Phe Tyr
     130                 135                 140

 ctc tta aat cct tac acg att ttg tct tgt gtt gcc aag tct acc tgt      480
 Leu Leu Asn Pro Tyr Thr Ile Leu Ser Cys Val Ala Lys Ser Thr Cys
 145                 150                 155                 160

 gcc atc aac aac acc ctc att gct ttc ttc att ttg act acg ata aaa      528
 Ala Ile Asn Asn Thr Leu Ile Ala Phe Phe Ile Leu Thr Thr Ile Lys
                 165                 170                 175

 ggc agt gct ttc ctc agt gct att ttt ctt gcc tta gcg aca tac cag      576
 Gly Ser Ala Phe Leu Ser Ala Ile Phe Leu Ala Leu Ala Thr Tyr Gln
             180                 185                 190

 tct ctg tac cca ctc acc ttg ttt gtc cca gga ctc ctc tat ctc ctc      624
 Ser Leu Tyr Pro Leu Thr Leu Phe Val Pro Gly Leu Leu Tyr Leu Leu
         195                 200                 205

 cag cgg cag tac ata cct gtg aaa atg aag agc aaa gcc ttc tgg atc      672
 Gln Arg Gln Tyr Ile Pro Val Lys Met Lys Ser Lys Ala Phe Trp Ile
     210                 215                 220

 ttt tct tgg gag tat gcc atg atg tat gtg gga agc cta gtg gta atc      720
 Phe Ser Trp Glu Tyr Ala Met Met Tyr Val Gly Ser Leu Val Val Ile
 225                 230                 235                 240

 att tgc ctc tcc ttc ttc ctt ctc agc tct tgg gat ttc atc ccc gca      768
 Ile Cys Leu Ser Phe Phe Leu Leu Ser Ser Trp Asp Phe Ile Pro Ala
                 245                 250                 255

 gtc tat ggc ttt ata ctt tct gtt cca gat ctc act cca aac att ggt      816
 Val Tyr Gly Phe Ile Leu Ser Val Pro Asp Leu Thr Pro Asn Ile Gly
             260                 265                 270

 ctt ttc tgg tac ttc ttt gca gag atg ttt gag cac ttc agc ctc ttc      864
 Leu Phe Trp Tyr Phe Phe Ala Glu Met Phe Glu His Phe Ser Leu Phe
         275                 280                 285

 ttt gta tgt gtg ttt cag atc aac gtc ttc ttc tac acc atc ccc tta      912
 Phe Val Cys Val Phe Gln Ile Asn Val Phe Phe Tyr Thr Ile Pro Leu
     290                 295                 300

 gcc ata aag cta aag gag cac ccc atc ttc ttc atg ttt atc cag atc      960
 Ala Ile Lys Leu Lys Glu His Pro Ile Phe Phe Met Phe Ile Gln Ile
 305                 310                 315                 320

 gct gtc atc gcc atc ttt aag tcc tac ccg aca gtg ggg gac gtg gcg     1008
 Ala Val Ile Ala Ile Phe Lys Ser Tyr Pro Thr Val Gly Asp Val Ala
                 325                 330                 335

 ctc tac atg gcc ttc ttc ccc gtg tgg aac cat ctc tac aga ttc ctg     1056
 Leu Tyr Met Ala Phe Phe Pro Val Trp Asn His Leu Tyr Arg Phe Leu
             340                 345                 350

 aga aac atc ttt gtc ctc acc tgc atc atc atc gtc tgt tcc ctg ctc     1104
 Arg Asn Ile Phe Val Leu Thr Cys Ile Ile Ile Val Cys Ser Leu Leu
         355                 360                 365

 ttc cct gtc ctg tgg cac ctc tgg att tat gca gga agt gcc aac tct     1152
 Phe Pro Val Leu Trp His Leu Trp Ile Tyr Ala Gly Ser Ala Asn Ser
     370                 375                 380

 aat ttc ttt tat gcc atc aca ctg acc ttc aac gtt ggg cag atc ctg     1200
 Asn Phe Phe Tyr Ala Ile Thr Leu Thr Phe Asn Val Gly Gln Ile Leu
 385                 390                 395                 400

 ctc atc tct gat tac ttc tat gcc ttc ctg cgg cgg gag tac tac ctc     1248
 Leu Ile Ser Asp Tyr Phe Tyr Ala Phe Leu Arg Arg Glu Tyr Tyr Leu
                 405                 410                 415

 aca cat ggc ctc tac ttg acc gcc aag gat ggc aca gag gcc atg ctc     1296
 Thr His Gly Leu Tyr Leu Thr Ala Lys Asp Gly Thr Glu Ala Met Leu
             420                 425                 430

 gtg ctc aag tag gcc tggctggcac agggctgcat ggacctcagg gggctgtggg     1351
 Val Leu Lys 
         435

 gccagaagct gggccaagcc ctccagccag agttgccagc aggcgagtgc ttgggcagaa   1411

 gaggttcgag tccagggtca caagtctctg gtaccaaaag ggacccatgg ctgactgaca   1471

 gcaaggccta tggggaagaa ctgggagctc cccaacttgg acccccacct tgtggctctg   1531

 cacaccaagg agccccctcc cagacaggaa ggagaagagg caggtgagca gggcttgtta   1591

 gattgtggct acttaataaa tgttttttgt tatgaagtct aaaaaaaaaa aa           1643




      <210> 43
      <211> 2001
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (849)..(1514)

      <400> 43
 ttaggcgatg aagggcaggt gaagaaatcc cgttccatct tcctgcagtc ctcccttggg     60

 gagtccacat cctatccttc tctggaccgg ggcggctctc cctctgcgat attgcgaata    120

 atattgtcgt ctccctttct ggatattagg agcaatatca gaaggaggat accctgcaat    180

 attggaagta atatcatcct ctaccaccct ggatgtgtgt acaccttttg caaaactggg    240

 agtaatattg tctccccccc caatattaaa aacaatatca cagggtgggt gtacactccc    300

 tgcgatattg gggttaacat catcctctct ttccctgata ttaaccacaa tgtcaaagta    360

 ggggtgtaca ccccctgcgc tattgggagt aatgtcatcc tttctccccc ccctccgata    420

 ttgggagtaa tatcctctcc ccttctggat attaaaagca atatcatagt gagggtgtac    480

 accctctgcg atattgggaa taatgtcatt ctctccacct cttgctttac agggagtaat    540

 atcctcctct ccacccacga tattaggagc aatatcatgg gggggggtgt tgtacatttc    600

 ctgcggtatt aggagtaata ttctctcctc cccctgggtc aatgtgcagt ccaagttgcc    660

 acaaatgacc ggaggaaaca gtgggaaggg aaggtctctt ttcccaattc caaaccagga    720

 tgcccttcag gtcgcccact tccttcatcc ccagagcagc tgccgacttt cctgttaagt    780

 gccagggcct gggaggagaa tttgggtcgg tgtcccacct ccacgatcac ttttctctta    840

 cacaggtg atg ctg acg tta gag gac aag gac atg aag gga ttc tcc tgg     890
          Met Leu Thr Leu Glu Asp Lys Asp Met Lys Gly Phe Ser Trp
            1               5                  10

 gcc ata gtc cca gcc tta acc tcc cta ggc tac ctg att ata ctg gtg      938
 Ala Ile Val Pro Ala Leu Thr Ser Leu Gly Tyr Leu Ile Ile Leu Val
  15                  20                  25                  30

 gtc tcc atc ttt ccc ttc tgg gtg cga ctg aca aac gag gag tcc cac      986
 Val Ser Ile Phe Pro Phe Trp Val Arg Leu Thr Asn Glu Glu Ser His
                  35                  40                  45

 gaa gtc ttt ttc agt ggc cta ttt gag aac tgc ttc aat gcc aaa tgc     1034
 Glu Val Phe Phe Ser Gly Leu Phe Glu Asn Cys Phe Asn Ala Lys Cys
              50                  55                  60

 tgg aag cct cga ccc tta tcc att tac atc atc ctc ggc cgg gtt ttc     1082
 Trp Lys Pro Arg Pro Leu Ser Ile Tyr Ile Ile Leu Gly Arg Val Phe
          65                  70                  75

 ctg ctc tct gca gtt ttc ttg gct ttc gtc acc acc ttc atc atg atg     1130
 Leu Leu Ser Ala Val Phe Leu Ala Phe Val Thr Thr Phe Ile Met Met
      80                  85                  90

 ccc ttt gca tcc gag ttc ttc ccg agg acc tgg aag caa aac ttt gtg     1178
 Pro Phe Ala Ser Glu Phe Phe Pro Arg Thr Trp Lys Gln Asn Phe Val
  95                 100                 105                 110

 tta gcc tgc atc agc ttc ttc aca ggg gcc tgt gcc ttc ctg gct ttg     1226
 Leu Ala Cys Ile Ser Phe Phe Thr Gly Ala Cys Ala Phe Leu Ala Leu
                 115                 120                 125

 gtg ctg cat gcc ctg gag atc aag gct ctg agg atg aag ctc ggc ccc     1274
 Val Leu His Ala Leu Glu Ile Lys Ala Leu Arg Met Lys Leu Gly Pro
             130                 135                 140

 ctg cag ttc tcc gtg ctg tgg cct tac tac gtg ctg ggc ttc ggc atc     1322
 Leu Gln Phe Ser Val Leu Trp Pro Tyr Tyr Val Leu Gly Phe Gly Ile
         145                 150                 155

 ttt ctg ttc ata gtg gct ggt acc atc tgc ctc att caa gaa atg gtt     1370
 Phe Leu Phe Ile Val Ala Gly Thr Ile Cys Leu Ile Gln Glu Met Val
     160                 165                 170

 tgc cct tgc tgg cac ttg ttg tcc act tcc cag agt atg gag gag gac     1418
 Cys Pro Cys Trp His Leu Leu Ser Thr Ser Gln Ser Met Glu Glu Asp
 175                 180                 185                 190

 cac ggg agc ctg tac ctg gac aat ctg gag agt ttg gga gga gaa ccg     1466
 His Gly Ser Leu Tyr Leu Asp Asn Leu Glu Ser Leu Gly Gly Glu Pro
                 195                 200                 205

 agc tca gta caa aag gag aca cag gtg aca gca gaa aca gtc atc tag     1514
 Ser Ser Val Gln Lys Glu Thr Gln Val Thr Ala Glu Thr Val Ile 
             210                 215                 220

 cccaggacat ggcttcttta cccttcttca agccatgtga gtgtacacat gtagctgttt   1574

 gtagtcctcc ccaccctctc tgccagtatc tgtgcctttg aggagcttct tgcgtgtcag   1634

 atcaactctc cacctcccca tactcacagt gattctatct tgcttgtatg tgaaatttgc   1694

 taaaagtcct ttcaactctt ctgagcttcc taagtgacgt ttttgcaggt attttcaata   1754

 aaaagaaggg ctactttgtt catccatatc tcaaaaacca agtccgcagg gcaggagggg   1814

 agggaggaat attacaagat aaccaagtga aatgggattt tgtgaaacag aaaccgtaca   1874

 gaatacagaa tatactcggg ggaatgacaa ctatttgggc tggtggcaca ggggtaaaag   1934

 aatttaccaa gacggttgta gataaagaaa ggcagattta ttaaaggaag tataaaagta   1994

 aaaaaaa                                                             2001




      <210> 44
      <211> 1224
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(1170)

      <400> 44
 ctgtgaattc cccttggccc tgctggtgcc gcatcagctg gacatgtggc cagggctttg     60

 agctgagggg taggtgcttg tacagtg    atg aca gac agc agg gtg gtc tgg     111
                                  Met Thr Asp Ser Arg Val Val Trp
                                    1               5

 gcc acc tct tgt gga gct ggc ttg cac cct cca gct ctg ctc tgc acc      159
 Ala Thr Ser Cys Gly Ala Gly Leu His Pro Pro Ala Leu Leu Cys Thr
      10                  15                  20

 act tct gtt tta tgc tgt ttt gct gct gag ccc acc caa tct tgt agg      207
 Thr Ser Val Leu Cys Cys Phe Ala Ala Glu Pro Thr Gln Ser Cys Arg
  25                  30                  35                  40

 tgg gtc ttg ctg ggc ttt ctg gtg gcg gcg acg ttc gcc tgg aac ctg      255
 Trp Val Leu Leu Gly Phe Leu Val Ala Ala Thr Phe Ala Trp Asn Leu
                  45                  50                  55

 ctg gtg ctg gcg acc atc ctc cgt gta cgc acc ttc cac cgc gtg ccc      303
 Leu Val Leu Ala Thr Ile Leu Arg Val Arg Thr Phe His Arg Val Pro
              60                  65                  70

 cac aac ctg gtg gca tcc atg gcc gtc tcg gat gtc ctg gtg gcc gcg      351
 His Asn Leu Val Ala Ser Met Ala Val Ser Asp Val Leu Val Ala Ala
          75                  80                  85

 ctg gtc atg ccg ctg agc ctg gtg cac gag ctg tcc ggg cgc cgc tgg      399
 Leu Val Met Pro Leu Ser Leu Val His Glu Leu Ser Gly Arg Arg Trp
      90                  95                 100

 cag cta ggt cgg agg ctg tgc cag ctt tgg atc gcg tgc gac gtg ctt      447
 Gln Leu Gly Arg Arg Leu Cys Gln Leu Trp Ile Ala Cys Asp Val Leu
 105                 110                 115                 120

 tgc tgc acg gcc agc atc tgg aac gtg acg gcc ata gcc ctg gac cgc      495
 Cys Cys Thr Ala Ser Ile Trp Asn Val Thr Ala Ile Ala Leu Asp Arg
                 125                 130                 135

 tac tgg tcc atc acg cgc cac atg gaa tac acg ctc cgc acc cgc aag      543
 Tyr Trp Ser Ile Thr Arg His Met Glu Tyr Thr Leu Arg Thr Arg Lys
             140                 145                 150

 tgc gtc tcc aac gtc atg atc gcg ctc acc tgg gca ctc tcc gct gtc      591
 Cys Val Ser Asn Val Met Ile Ala Leu Thr Trp Ala Leu Ser Ala Val
         155                 160                 165

 atc tct ctg gcc ccg ctg ctt ttt ggc tgg gga gag acg tac tct gag      639
 Ile Ser Leu Ala Pro Leu Leu Phe Gly Trp Gly Glu Thr Tyr Ser Glu
     170                 175                 180

 ggc agc gag gag tgc cag gta agc cgc gag cct tcc tac gcc gtg ttc      687
 Gly Ser Glu Glu Cys Gln Val Ser Arg Glu Pro Ser Tyr Ala Val Phe
 185                 190                 195                 200

 tcc acc gta ggc gcc ttc tac ctg ccg ctc tgt gtg gtg ctc ttc gtg      735
 Ser Thr Val Gly Ala Phe Tyr Leu Pro Leu Cys Val Val Leu Phe Val
                 205                 210                 215

 tac tgg aag atc tac aag gct gcc aag ttc cgc gtg ggc tcc agg aag      783
 Tyr Trp Lys Ile Tyr Lys Ala Ala Lys Phe Arg Val Gly Ser Arg Lys
             220                 225                 230

 acc aat agc gtc tca ccc ata tcc gaa gct gtg gag gtg aag gac tct      831
 Thr Asn Ser Val Ser Pro Ile Ser Glu Ala Val Glu Val Lys Asp Ser
         235                 240                 245

 gcc aaa cag ccc cag atg gtg ttc acg gtc cgc cac gcc acc gtc acc      879
 Ala Lys Gln Pro Gln Met Val Phe Thr Val Arg His Ala Thr Val Thr
     250                 255                 260

 ttc cag cca gaa ggg gac acg tgg cgg gag cag aag gag cag cgg gcc      927
 Phe Gln Pro Glu Gly Asp Thr Trp Arg Glu Gln Lys Glu Gln Arg Ala
 265                 270                 275                 280

 gcc ctc atg gtg ggc atc ctc att ggc gtg ttc gtg ctc tgc tgg atc      975
 Ala Leu Met Val Gly Ile Leu Ile Gly Val Phe Val Leu Cys Trp Ile
                 285                 290                 295

 ccc ttc ttt ctc acc gag ctc atc agt ccc ctc tgc tcc tgt gac atc     1023
 Pro Phe Phe Leu Thr Glu Leu Ile Ser Pro Leu Cys Ser Cys Asp Ile
             300                 305                 310

 ccc gcc atc tgg aaa agc atc ttc ctg tgg ctt ggc tac tcc aac tcc     1071
 Pro Ala Ile Trp Lys Ser Ile Phe Leu Trp Leu Gly Tyr Ser Asn Ser
         315                 320                 325

 ttc ttt aac ccc ctg atc tat acg gct ttc aac aag aac tac aac agc     1119
 Phe Phe Asn Pro Leu Ile Tyr Thr Ala Phe Asn Lys Asn Tyr Asn Ser
     330                 335                 340

 gcc ttc aag aac ttc ttt tct agg caa cac ttt att aga tgg tgc acc     1167
 Ala Phe Lys Asn Phe Phe Ser Arg Gln His Phe Ile Arg Trp Cys Thr
 345                 350                 355                 360

 tag agaa ggctggaggg tttcctgcaa gccctctctg tagggtgact gaggtgaacc     1224
 






      <210> 45
      <211> 1558
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (212)..(1222)

      <400> 45
 cccacgcgtc cgattggaag agtgaagagc agagaatttt aagtctgaaa tttggcatca     60

 ctgccctgaa caatataacc ttagttggca taaactactc atacagacaa aggcattatc    120

 catcacaata agtaactttt tgtctttatt tcaaccggac aatcgtgatt agaaaagctc    180

 ctgtgacaaa attcaagaaa acctgacata a   atg aac aac aat aca aca tgt     232
                                      Met Asn Asn Asn Thr Thr Cys
                                        1               5

 att caa cca tct atg atc tct tcc atg gct tta cca atc att tac atc      280
 Ile Gln Pro Ser Met Ile Ser Ser Met Ala Leu Pro Ile Ile Tyr Ile
          10                  15                  20

 ctc ctt tgt att gtt ggt gtt ttt gga aac act ctc tct caa tgg ata      328
 Leu Leu Cys Ile Val Gly Val Phe Gly Asn Thr Leu Ser Gln Trp Ile
      25                  30                  35

 ttt tta aca aaa ata ggt aaa aaa aca tca acg cac atc tac ctg tca      376
 Phe Leu Thr Lys Ile Gly Lys Lys Thr Ser Thr His Ile Tyr Leu Ser
  40                  45                  50                  55

 cac ctt gtg act gca aac tta ctt gtg tgc agt gcc atg cct ttc atg      424
 His Leu Val Thr Ala Asn Leu Leu Val Cys Ser Ala Met Pro Phe Met
                  60                  65                  70

 agt atc tat ttc ctg aaa ggt ttc caa tgg gaa tat caa tct gct caa      472
 Ser Ile Tyr Phe Leu Lys Gly Phe Gln Trp Glu Tyr Gln Ser Ala Gln
              75                  80                  85

 tgc aga gtg gtc aat ttt ctg gga act cta tcc atg cat gca agt atg      520
 Cys Arg Val Val Asn Phe Leu Gly Thr Leu Ser Met His Ala Ser Met
          90                  95                 100

 ttt gtc agt ctc tta att tta agt tgg att gcc ata agc cgc tat gct      568
 Phe Val Ser Leu Leu Ile Leu Ser Trp Ile Ala Ile Ser Arg Tyr Ala
     105                 110                 115

 acc tta atg caa aag gat tcc tcg caa gag act act tca tgc tat gag      616
 Thr Leu Met Gln Lys Asp Ser Ser Gln Glu Thr Thr Ser Cys Tyr Glu
 120                 125                 130                 135

 aaa ata ttt tat ggc cat tta ctg aaa aaa ttt cgc cag ccc aac ttt      664
 Lys Ile Phe Tyr Gly His Leu Leu Lys Lys Phe Arg Gln Pro Asn Phe
                 140                 145                 150

 gct aga aaa cta tgc att tac ata tgg gga gtt gta ctg ggc ata atc      712
 Ala Arg Lys Leu Cys Ile Tyr Ile Trp Gly Val Val Leu Gly Ile Ile
             155                 160                 165

 att cca gtt acc gta tac tac tca gtc ata gag gct aca gaa gga gaa      760
 Ile Pro Val Thr Val Tyr Tyr Ser Val Ile Glu Ala Thr Glu Gly Glu
         170                 175                 180

 gag agc cta tgc tac aat cgg cag atg gaa cta gga gcc atg atc tct      808
 Glu Ser Leu Cys Tyr Asn Arg Gln Met Glu Leu Gly Ala Met Ile Ser
     185                 190                 195

 cag att gca ggt ctc att gga acc aca ttt att gga ttt tcc ttt tta      856
 Gln Ile Ala Gly Leu Ile Gly Thr Thr Phe Ile Gly Phe Ser Phe Leu
 200                 205                 210                 215

 gta gta cta aca tca tac tac tct ttt gta agc cat ctg aga aaa ata      904
 Val Val Leu Thr Ser Tyr Tyr Ser Phe Val Ser His Leu Arg Lys Ile
                 220                 225                 230

 aga acc tgt acg tcc att atg gag aaa gat ttg act tac agt tct gtg      952
 Arg Thr Cys Thr Ser Ile Met Glu Lys Asp Leu Thr Tyr Ser Ser Val
             235                 240                 245

 aaa aga cat ctt ttg gtc atc cag att cta cta ata gtt tgc ttc ctt     1000
 Lys Arg His Leu Leu Val Ile Gln Ile Leu Leu Ile Val Cys Phe Leu
         250                 255                 260

 cct tat agt att ttt aaa ccc att ttt tat gtt cta cac caa aga gat     1048
 Pro Tyr Ser Ile Phe Lys Pro Ile Phe Tyr Val Leu His Gln Arg Asp
     265                 270                 275

 aac tgt cag caa ttg aat tat tta ata gaa aca aaa aac att ctc acc     1096
 Asn Cys Gln Gln Leu Asn Tyr Leu Ile Glu Thr Lys Asn Ile Leu Thr
 280                 285                 290                 295

 tgt ctt gct tcg gcc aga agt agc aca gac ccc att ata ttt ctt tta     1144
 Cys Leu Ala Ser Ala Arg Ser Ser Thr Asp Pro Ile Ile Phe Leu Leu
                 300                 305                 310

 tta gat aaa aca ttc aag aag aca cta tat aat ctc ttt aca aag tct     1192
 Leu Asp Lys Thr Phe Lys Lys Thr Leu Tyr Asn Leu Phe Thr Lys Ser
             315                 320                 325

 aat tca gca cat atg caa tca tat ggt tga c ttttgaatgg aaaaccccac     1243
 Asn Ser Ala His Met Gln Ser Tyr Gly 
         330                 335

 aatattaaga aaagcattca tgtgacttta ttagggacac taaactacat cattaacatg   1303

 tcacagcttg gttgacaata atcaccaaga aaatctcttt ggtttttaaa aataaataaa   1363

 catatattca taaaactcaa aaaacagtta tactgaacgt tgagatggca gaaactttca   1423

 gaagcaaaaa ttaagcatat tgaaaggatc ccactcatat gaaactaaca ggctgttttc   1483

 tgtttaaact caactgtcag tgcttctgtt cagaacacgt tatttcatga ctaggataaa   1543

 gaagcaaatg gttta                                                    1558




      <210> 46
      <211> 2315
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (213)..(2126)

      <400> 46
 gctggggctg gggctggggc tgggagggag ctaataaaca ttgaatgtgc agcagctgcc     60

 ttggcgggcg gagtccgccc gagcgacacc ggagcagtgc gcccgggagg cggcgagaga    120

 aggcggcgga aggtggagat tgatgcttct gttttttgtt gccgctgctg ccctcgcgct    180

 gggagccgag ccggagggaa ggcggtggag ag  atg att gca gag ttg gtg agc     233
                                      Met Ile Ala Glu Leu Val Ser
                                        1               5

 agc gct ctg ggg ctc gcc ttg tat ctc aac acc ctg agt gcg gat ttc      281
 Ser Ala Leu Gly Leu Ala Leu Tyr Leu Asn Thr Leu Ser Ala Asp Phe
          10                  15                  20

 tgc tat gat gac agc cgt gct atc aag act aat cag gac ctt ctc cca      329
 Cys Tyr Asp Asp Ser Arg Ala Ile Lys Thr Asn Gln Asp Leu Leu Pro
      25                  30                  35

 gaa act cca tgg acg cac att ttc tac aat gat ttt tgg ggg act ctt      377
 Glu Thr Pro Trp Thr His Ile Phe Tyr Asn Asp Phe Trp Gly Thr Leu
  40                  45                  50                  55

 cta acc cac agt ggc agc cac aag tcc tac cgg cca ctc tgc act ctt      425
 Leu Thr His Ser Gly Ser His Lys Ser Tyr Arg Pro Leu Cys Thr Leu
                  60                  65                  70

 tct ttt cgc ctg aac cat gcc att gga ggg ttg aat ccc tgg agc tac      473
 Ser Phe Arg Leu Asn His Ala Ile Gly Gly Leu Asn Pro Trp Ser Tyr
              75                  80                  85

 cat ctt gtc aat gtc ctg ttg cat gca gca gtc act ggt ctc ttc aca      521
 His Leu Val Asn Val Leu Leu His Ala Ala Val Thr Gly Leu Phe Thr
          90                  95                 100

 agc ttc tcc aag atc ctc ctt ggt gat gga tac tgg aca ttc atg gct      569
 Ser Phe Ser Lys Ile Leu Leu Gly Asp Gly Tyr Trp Thr Phe Met Ala
     105                 110                 115

 ggc ttg atg ttt gct tct cac ccc att cac acg gag gca gtg gca gga      617
 Gly Leu Met Phe Ala Ser His Pro Ile His Thr Glu Ala Val Ala Gly
 120                 125                 130                 135

 atc gtg gga cga gcc gat gtc ggg gcc agt ctc ttc ttt ctc ctc tcc      665
 Ile Val Gly Arg Ala Asp Val Gly Ala Ser Leu Phe Phe Leu Leu Ser
                 140                 145                 150

 ttg ctc tgc tac att aaa cac tgt tct aca aga ggc tac tca gcc aga      713
 Leu Leu Cys Tyr Ile Lys His Cys Ser Thr Arg Gly Tyr Ser Ala Arg
             155                 160                 165

 acc tgg ggc tgg ttc ctg ggg tca gga ctg tgc gca gga tgc agc atg      761
 Thr Trp Gly Trp Phe Leu Gly Ser Gly Leu Cys Ala Gly Cys Ser Met
         170                 175                 180

 ttg tgg aag gaa caa gga gtg act gtt ctc gca gtt tca gca gtt tat      809
 Leu Trp Lys Glu Gln Gly Val Thr Val Leu Ala Val Ser Ala Val Tyr
     185                 190                 195

 gat gtc ttt gtc ttt cac agg ctg aaa ata aaa cag ata tta cct acc      857
 Asp Val Phe Val Phe His Arg Leu Lys Ile Lys Gln Ile Leu Pro Thr
 200                 205                 210                 215

 att tac aaa agg aag aac ttg tcg ctt ttc cta agc att agt ttg tta      905
 Ile Tyr Lys Arg Lys Asn Leu Ser Leu Phe Leu Ser Ile Ser Leu Leu
                 220                 225                 230

 att ttc tgg ggt tcc tcc ctt ttg ggt gcc cgg tta tac tgg atg gga      953
 Ile Phe Trp Gly Ser Ser Leu Leu Gly Ala Arg Leu Tyr Trp Met Gly
             235                 240                 245

 aac aaa cca cca agc ttt tcc aac tcg gac aac ccc gct ggt gat tcg     1001
 Asn Lys Pro Pro Ser Phe Ser Asn Ser Asp Asn Pro Ala Gly Asp Ser
         250                 255                 260

 gac agc ctc ctc acc cgc act ctc acc ttg ttc tac ttg cca acc aag     1049
 Asp Ser Leu Leu Thr Arg Thr Leu Thr Leu Phe Tyr Leu Pro Thr Lys
     265                 270                 275

 aac ctc tgg ctg ttg cta tgt cca gat acc ctc agt ttt gat tgg tca     1097
 Asn Leu Trp Leu Leu Leu Cys Pro Asp Thr Leu Ser Phe Asp Trp Ser
 280                 285                 290                 295

 atg gat gct gtg cct ctg ctc aaa aca gtt tgt gac tgg aga aac cta     1145
 Met Asp Ala Val Pro Leu Leu Lys Thr Val Cys Asp Trp Arg Asn Leu
                 300                 305                 310

 cac act gtg gcc ttc tat act gga ctc ctt ctc ctt gcc tac tat ggt     1193
 His Thr Val Ala Phe Tyr Thr Gly Leu Leu Leu Leu Ala Tyr Tyr Gly
             315                 320                 325

 ttg aag agc ccg agc gta gac aga gaa tgc aat ggg aaa act gta aca     1241
 Leu Lys Ser Pro Ser Val Asp Arg Glu Cys Asn Gly Lys Thr Val Thr
         330                 335                 340

 aat ggc aag cag aat gca aat gga cat agc tgc ctt tca gat gtg gag     1289
 Asn Gly Lys Gln Asn Ala Asn Gly His Ser Cys Leu Ser Asp Val Glu
     345                 350                 355

 tac cag aac tca gag act aag tcc agc ttt gca tcc aaa gta gaa aat     1337
 Tyr Gln Asn Ser Glu Thr Lys Ser Ser Phe Ala Ser Lys Val Glu Asn
 360                 365                 370                 375

 ggc att aaa aac gat gta tca cag aga acc cag ctt cct tct acg gag     1385
 Gly Ile Lys Asn Asp Val Ser Gln Arg Thr Gln Leu Pro Ser Thr Glu
                 380                 385                 390

 aac att gtt gtt ctg tct tta tct ttg tta atc ata ccc ttt gtt cct     1433
 Asn Ile Val Val Leu Ser Leu Ser Leu Leu Ile Ile Pro Phe Val Pro
             395                 400                 405

 gcc acg aac ctg ttt ttc tat gtc ggc ttt gta att gca gag cga gta     1481
 Ala Thr Asn Leu Phe Phe Tyr Val Gly Phe Val Ile Ala Glu Arg Val
         410                 415                 420

 tta tat att cct agt atg ggc ttc tgc cta ctg att aca gtg ggt gct     1529
 Leu Tyr Ile Pro Ser Met Gly Phe Cys Leu Leu Ile Thr Val Gly Ala
     425                 430                 435

 aga gcc ctt tat gtc aaa gtc caa aag cgg ttc ctc aag agc ttg att     1577
 Arg Ala Leu Tyr Val Lys Val Gln Lys Arg Phe Leu Lys Ser Leu Ile
 440                 445                 450                 455

 ttt tat gct aca gct aca cta att gtt ttt tat gga ctc aag act gcg     1625
 Phe Tyr Ala Thr Ala Thr Leu Ile Val Phe Tyr Gly Leu Lys Thr Ala
                 460                 465                 470

 atc agg aat gga gac tgg cag aat gag gaa atg ctt tat aga tca ggg     1673
 Ile Arg Asn Gly Asp Trp Gln Asn Glu Glu Met Leu Tyr Arg Ser Gly
             475                 480                 485

 ata aaa gta aac cca gct aaa gca tgg ggt aac ctt gga aat gtt ctg     1721
 Ile Lys Val Asn Pro Ala Lys Ala Trp Gly Asn Leu Gly Asn Val Leu
         490                 495                 500

 aag agt cag agc aaa att tct gaa gct gaa agc gcc tat aga aat gct     1769
 Lys Ser Gln Ser Lys Ile Ser Glu Ala Glu Ser Ala Tyr Arg Asn Ala
     505                 510                 515

 ttg tac tac cgc agc aac atg gct gac atg ctt tat aat tta ggg cta     1817
 Leu Tyr Tyr Arg Ser Asn Met Ala Asp Met Leu Tyr Asn Leu Gly Leu
 520                 525                 530                 535

 ctt ctc cag gag aac agc agg ttt gca gaa gca cta cat tat tat aaa     1865
 Leu Leu Gln Glu Asn Ser Arg Phe Ala Glu Ala Leu His Tyr Tyr Lys
                 540                 545                 550

 ttg gcc att ggg agc agg cct acc ctg gct tct gca tat tta aat acc     1913
 Leu Ala Ile Gly Ser Arg Pro Thr Leu Ala Ser Ala Tyr Leu Asn Thr
             555                 560                 565

 ggt att att cta atg aac caa gga agg acg gaa gaa gcc cga cgg aca     1961
 Gly Ile Ile Leu Met Asn Gln Gly Arg Thr Glu Glu Ala Arg Arg Thr
         570                 575                 580

 ttc tta aag tgt tcg gag atc cca gat gaa aac cta aag gac cct cat     2009
 Phe Leu Lys Cys Ser Glu Ile Pro Asp Glu Asn Leu Lys Asp Pro His
     585                 590                 595

 gca cac aag agc tct gtt acc agt tgt ttg tac aac cta gga aag ctg     2057
 Ala His Lys Ser Ser Val Thr Ser Cys Leu Tyr Asn Leu Gly Lys Leu
 600                 605                 610                 615

 tat cat gag cag gga cac tat gag gtc tgg cca atg cct ctc tgt cct     2105
 Tyr His Glu Gln Gly His Tyr Glu Val Trp Pro Met Pro Leu Cys Pro
                 620                 625                 630

 ttt ccc tcc ccc ttg ttc tga tc cagtctcagt ggtttgtaac ctacagcctc     2158
 Phe Pro Ser Pro Leu Phe 
             635

 ctttgagcct atgtcctttg aacaactaat atgtatacac gttaaactat tgtcctttga   2218

 gaaactaata catgatgaca ttggaatggt tttttgatca aatttgttta gaaaaagctt   2278

 ctgctaaata aaaatttaat agatttaaaa aaaaaaa                            2315




      <210> 47
      <211> 2476
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (564)..(2117)

      <400> 47
 gccctggtgg ctgtttccca ccttcagccc tggctcctgt ggctagagcc ctggtgccca     60

 cagctcaacc tggacctgtc cacccttgaa gggctcatga tgcagcatca gggagtccca    120

 gatcgagccg ctgacacctc caagtcggct gcagctgtgc atccgctcag accacaagac    180

 tcaatggagg atgctgacct ctctttgttc tcccaacgag tactaggcaa ggagggaagg    240

 aagaagagga agctaaggcc tgggttgggt aactgcctga cgttttactg taagtgcatt    300

 gtgtgcccaa gctcagggtt gtcccgtcta gaccattaaa gtcacacagt gcaatttaag    360

 aagacaatca ggcaatctca gctcggtggg agcccgaggc tctctgtttc ctcgagtcac    420

 tcccagatta gtggtgtcta gctcagcact gtttctgtta tacttcattc ataattccca    480

 gcgctgttgg acgaggatgg gaagaccgcc tgtggccatg agccctcccc ggtgctcctg    540

 gggctaaggc tggggctgca gcc    atg ggg ctg ggt cag ccc cag gcc tgg     590
                              Met Gly Leu Gly Gln Pro Gln Ala Trp
                                1               5

 ttg ctg ggt ctg ccc aca gct gtg gtc tat ggc tcc ctg gct ctc ttc      638
 Leu Leu Gly Leu Pro Thr Ala Val Val Tyr Gly Ser Leu Ala Leu Phe
  10                  15                  20                  25

 acc acc atc ctg cac aat gtc ttc ctg ctc tac tat gtg gac acc ttt      686
 Thr Thr Ile Leu His Asn Val Phe Leu Leu Tyr Tyr Val Asp Thr Phe
                  30                  35                  40

 gtc tca gtg tac aag atc aac aaa atg gcc ttc tgg gtc gga gag aca      734
 Val Ser Val Tyr Lys Ile Asn Lys Met Ala Phe Trp Val Gly Glu Thr
              45                  50                  55

 gtg ttt ctc ctc tgg aac agc ctc aat gac ccc ctc ttc ggt tgg ctc      782
 Val Phe Leu Leu Trp Asn Ser Leu Asn Asp Pro Leu Phe Gly Trp Leu
          60                  65                  70

 agt gac cgg cag ttc ctc agc tcc cag ccc cgg tca ggc gcc ggg ctc      830
 Ser Asp Arg Gln Phe Leu Ser Ser Gln Pro Arg Ser Gly Ala Gly Leu
      75                  80                  85

 tcc tca agg gct gtg gtg ctg gcc cgg gtg cag gcc ctg ggc tgg cat      878
 Ser Ser Arg Ala Val Val Leu Ala Arg Val Gln Ala Leu Gly Trp His
  90                  95                 100                 105

 ggg ccg ctg ctg gcg ctg tcg ttc ctg gcg ttc tgg gtg ccc tgg gcc      926
 Gly Pro Leu Leu Ala Leu Ser Phe Leu Ala Phe Trp Val Pro Trp Ala
                 110                 115                 120

 cca gct ggc ctg cag ttc ttg ctg tgc ctg tgc ctc tat gat ggc ttc      974
 Pro Ala Gly Leu Gln Phe Leu Leu Cys Leu Cys Leu Tyr Asp Gly Phe
             125                 130                 135

 ctg acg ctc gtg gac ctg cac cac cat gcc ttg ctg gcc gac ctg gcc     1022
 Leu Thr Leu Val Asp Leu His His His Ala Leu Leu Ala Asp Leu Ala
         140                 145                 150

 ctc tca gcc cac gac cgc acc cac ctc aac ttc tac tgc tcc ctc ttc     1070
 Leu Ser Ala His Asp Arg Thr His Leu Asn Phe Tyr Cys Ser Leu Phe
     155                 160                 165

 agc gcg gcc ggc tcc ctc tct gtc ttt gca tcc tat gcc ttt tgg aac     1118
 Ser Ala Ala Gly Ser Leu Ser Val Phe Ala Ser Tyr Ala Phe Trp Asn
 170                 175                 180                 185

 aag gag gat ttc tcc tcc ttc cgc gct ttc tgc gtg aca ctg gct gtc     1166
 Lys Glu Asp Phe Ser Ser Phe Arg Ala Phe Cys Val Thr Leu Ala Val
                 190                 195                 200

 agc tct ggg ctg ggc ttt ctg ggg gcc aca cag ctg ctg agg cgg cgg     1214
 Ser Ser Gly Leu Gly Phe Leu Gly Ala Thr Gln Leu Leu Arg Arg Arg
             205                 210                 215

 gtt gag gcg gcc cga aag gac cca ggg tgc tca ggc ctg gtt gtg gat     1262
 Val Glu Ala Ala Arg Lys Asp Pro Gly Cys Ser Gly Leu Val Val Asp
         220                 225                 230

 agc ggc ctg tgt gga gag gag ctg ctt gta ggc agt gag gag gcg gac     1310
 Ser Gly Leu Cys Gly Glu Glu Leu Leu Val Gly Ser Glu Glu Ala Asp
     235                 240                 245

 agc atc acc ttg ggc cgg tat ctc cgg cag ctg gca cgc cat cgg aac     1358
 Ser Ile Thr Leu Gly Arg Tyr Leu Arg Gln Leu Ala Arg His Arg Asn
 250                 255                 260                 265

 ttc ctg tgg ttc gtg agc atg gac ctg gtg cag gtc ttc cac tgc cac     1406
 Phe Leu Trp Phe Val Ser Met Asp Leu Val Gln Val Phe His Cys His
                 270                 275                 280

 ttc aac agc aac ttc ttc cct ctc ttc ctg gag cat ctg ttg tcc gac     1454
 Phe Asn Ser Asn Phe Phe Pro Leu Phe Leu Glu His Leu Leu Ser Asp
             285                 290                 295

 cat atc tcc ctt tcc acg ggc tcc atc ctg ttg ggc ctc tcc tat gtc     1502
 His Ile Ser Leu Ser Thr Gly Ser Ile Leu Leu Gly Leu Ser Tyr Val
         300                 305                 310

 gct ccc cat ctc aac aac ctc tac ttc ctg tcc ctg tgc cgg cgc tgg     1550
 Ala Pro His Leu Asn Asn Leu Tyr Phe Leu Ser Leu Cys Arg Arg Trp
     315                 320                 325

 ggc gtc tac gcg gtg gtg cgg ggg ctc ttc ctg ctc aag ctg gga ctt     1598
 Gly Val Tyr Ala Val Val Arg Gly Leu Phe Leu Leu Lys Leu Gly Leu
 330                 335                 340                 345

 agc ctg ctc atg ttg ttg gcc ggc ccg gac cac ctc agc ctg ctg tgc     1646
 Ser Leu Leu Met Leu Leu Ala Gly Pro Asp His Leu Ser Leu Leu Cys
                 350                 355                 360

 ctc ttc att gcc agc aac cgc gtc ttc act gag ggc acc tgt aag ctg     1694
 Leu Phe Ile Ala Ser Asn Arg Val Phe Thr Glu Gly Thr Cys Lys Leu
             365                 370                 375

 ctg acc ttg gtg gtc act gac ctg gta gac gag gac ctg gtg ctg aac     1742
 Leu Thr Leu Val Val Thr Asp Leu Val Asp Glu Asp Leu Val Leu Asn
         380                 385                 390

 cac cgc aag cag gca gcc tcg gca ctc ctc ttt ggc atg gtt gcc ttg     1790
 His Arg Lys Gln Ala Ala Ser Ala Leu Leu Phe Gly Met Val Ala Leu
     395                 400                 405

 gtg acc aag cca ggc cag acc ttt gcc ccg ctg ctg ggc acc tgg ctg     1838
 Val Thr Lys Pro Gly Gln Thr Phe Ala Pro Leu Leu Gly Thr Trp Leu
 410                 415                 420                 425

 ctc tgt ttc tac aca ggt cat gac ctc ttc cag cag tcc ctc ata acc     1886
 Leu Cys Phe Tyr Thr Gly His Asp Leu Phe Gln Gln Ser Leu Ile Thr
                 430                 435                 440

 cct gtg ggg agt gcc cat ccc tgg cca gag ccc cca gct cca gcc cct     1934
 Pro Val Gly Ser Ala His Pro Trp Pro Glu Pro Pro Ala Pro Ala Pro
             445                 450                 455

 gca cag gcc ccg acg ctc cgc cag ggc tgc ttc tac ctg ctg gtg ctg     1982
 Ala Gln Ala Pro Thr Leu Arg Gln Gly Cys Phe Tyr Leu Leu Val Leu
         460                 465                 470

 gtg ccc atc acc tgt gct ctg ctg cag ctc ttc acc tgg tcc cag ttc     2030
 Val Pro Ile Thr Cys Ala Leu Leu Gln Leu Phe Thr Trp Ser Gln Phe
     475                 480                 485

 acg ctg cat ggg aga cgc ctg cac atg gtc aag gcc cag cgc cag aac     2078
 Thr Leu His Gly Arg Arg Leu His Met Val Lys Ala Gln Arg Gln Asn
 490                 495                 500                 505

 ctg tca cag gcc caa acc ctg gat gtt aag atg gtg tga gagctgtggc      2127
 Leu Ser Gln Ala Gln Thr Leu Asp Val Lys Met Val 
                 510                 515

 aaggtcaccc cactgaggat gctgctggca gcctggggaa ggagccagtt tttttttggt   2187

 ttttttttta aggatttcat agtttttttt tttttttttg ggaaaggtgc ccaaaaaaaa   2247

 gggatttgtg gaagggggga atttgggtct cattgaaccc cccccccggg ttaaagcatt   2307

 ttccctggtt aaccttccga agtgggggga attataggag cggtccattt ggccgggttt   2367

 ttttttcttt tttaagtaaa aacggggtct aacattgtgg cccgggcttt tttatacccc   2427

 tcttttttgt tttacaatcc cccttgccct ctccataact ggttttttc               2476




      <210> 48
      <211> 761
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (177)..(401)

      <400> 48
 gatggtaggg tgggggcagt ttagttccca atggatattt ctggtttttg cagaaaaagt     60

 aggaaaggga agtgggatgg tttacctctt tgtcaggaaa gttaggtaac tattagtaaa    120

 aaacaattat acactttaaa atcctgcaat tattttacag aaagcactaa aactgc        176                                                                 
 atg cat ggg aag atc act cca ttt cag atg tat ttg tta cac agt atc      224
 Met His Gly Lys Ile Thr Pro Phe Gln Met Tyr Leu Leu His Ser Ile
   1               5                  10                  15

 ttg ttt atg ctg tgc tta gta ggc atg gtt gaa ttc aat aaa agc aca      272
 Leu Phe Met Leu Cys Leu Val Gly Met Val Glu Phe Asn Lys Ser Thr
              20                  25                  30

 cgt gaa tgc att tta ttt aag aca cta tgg cta ata cca ctg ttt aca      320
 Arg Glu Cys Ile Leu Phe Lys Thr Leu Trp Leu Ile Pro Leu Phe Thr
          35                  40                  45

 tat aaa ctg gcg tat cta tgt gag aaa ctc aag ttt gtg aaa ttc tgt      368
 Tyr Lys Leu Ala Tyr Leu Cys Glu Lys Leu Lys Phe Val Lys Phe Cys
      50                  55                  60

 gca tct ttg cta att gct gtg ttt gat cat tga catttctg acatgccaca      419
 Ala Ser Leu Leu Ile Ala Val Phe Asp His 
  65                  70

 tgggcctgcg gggctgtcat cccctgggct gacaactggt actcggcccg tccttgtaat    479

 ccagcagtat tttttcatac atttgaaaca tttagaggaa aattcagtaa ttgaataatt    539

 gtttgtaaat attctgatcg aaaatgaaaa aattcccctt aatgaaacct gaactctgct    599

 tctgattagc ttatatgact taaagcttca cttcagttcc cttgaaacca ttacatcttt    659

 tataaaatga aagcactaag cagtccctaa ggtttttctc aacatgttgg gaagccaatt    719

 ttattttata gcataatgtg tttattctta cttgatcata tc                       761




      <210> 49
      <211> 435
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (167)..(334)

      <400> 49
 ctgaaatgta cataagagaa ccaatttagt aataaaactt tccttttcta cttaggctca     60

 atctaaagaa acagaataaa gctattaata ttttatggcc acaaatatga gaatggctat    120

 aatagtatac ttaaatatgc tggttactaa aaaaatgtaa gctgaa   atg atg acg     175
                                                      Met Met Thr
                                                        1

 tgt tct ttt aga agg ttt atc ata gca act act ata ggc agt gat tct      223
 Cys Ser Phe Arg Arg Phe Ile Ile Ala Thr Thr Ile Gly Ser Asp Ser
       5                  10                  15

 aag aag atg cta ttc ttt ttt tcc att gct ttg tct agt ttt ttt ttt      271
 Lys Lys Met Leu Phe Phe Phe Ser Ile Ala Leu Ser Ser Phe Phe Phe
  20                  25                  30                  35

 tta aat ctg ttt ttg tgc ctt tgt aat tct agg gtt att ggt ata gtt      319
 Leu Asn Leu Phe Leu Cys Leu Cys Asn Ser Arg Val Ile Gly Ile Val
                  40                  45                  50

 ctc acc ata tct tga atacagatgc tttttccttt ggaaataatt tctcataaag      374
 Leu Thr Ile Ser 
              55

 cacattgctt atagctgctt cccttttccc agagtagtaa aagttgtgat acaagacagt    434

 g                                                                    435




      <210> 50
      <211> 1528
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(895)

      <400> 50
 gtcctccaaa aggaaggtga cttttaagaa gcaatccaga agaggtcccc gcccaacctt     60

 caaaattctg tccaaaagca gacaagagga tcgccccgcg ctgagccggc tggtgggcag    120

 caggaggcgc ctgatcgccg ccggggcgct gggggtggtg  atg gtg ctg ctg ctg     175
                                              Met Val Leu Leu Leu
                                                1               5

 gtg atc ctc atc ccg gtg ctg atg ctg ggc acc tgc cgc atg gtc tgc      223
 Val Ile Leu Ile Pro Val Leu Met Leu Gly Thr Cys Arg Met Val Cys
                  10                  15                  20

 gac ccc tac ggg ggc acc aag gcg ccc agc acc gct gcc acg ccc gac      271
 Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala Thr Pro Asp
              25                  30                  35

 cgc ggc ctc atg cag tcc ctg ccc acc ttc atc cag ggc ccc aaa ggc      319
 Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly Pro Lys Gly
          40                  45                  50

 gag gcc ggc agg ccc ggg aag gcg ggt ccg cgc ggg ccc ccc gga gag      367
 Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro Pro Gly Glu
      55                  60                  65

 ccc ggg cca ccc ggc ccc atg ggg ccc ccg ggc gag aag ggc gag ccg      415
 Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys Gly Glu Pro
  70                  75                  80                  85

 ggc cgc caa ggc ctg ccg ggc ccg ccc ggg gcg ccc ggc ctg aac gcg      463
 Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly Leu Asn Ala
                  90                  95                 100

 gcc ggg gcc atc agc gcc gcc acc tac agc acg ggg ccc aag atc gcc      511
 Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Gly Pro Lys Ile Ala
             105                 110                 115

 ttc tac gcc ggc ctc aag cgg cag cat gaa ggc tac gag gtg ctc aag      559
 Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu Val Leu Lys
         120                 125                 130

 ttc gac gac gtg gtc acc aac ctc gga aac cac tac gac ccc acc acc      607
 Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp Pro Thr Thr
     135                 140                 145

 ggc aag ttc acc tgc tcc atc ccg ggc atc tac ttc ttc acc tac cac      655
 Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe Thr Tyr His
 150                 155                 160                 165

 gtc ctg atg cgc gga ggg gac ggc acc agc atg tgg gct gat ctc tgc      703
 Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala Asp Leu Cys
                 170                 175                 180

 aaa aac aac cag gtg cgt gct agt gca att gcc caa gat gct gat cag      751
 Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp Ala Asp Gln
             185                 190                 195

 aat tac gac tat gcc agt aac agt gtg gtt ctt cat ttg gag ccg gga      799
 Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu Glu Pro Gly
         200                 205                 210

 gat gaa gtc tat atc aaa tta gat ggc ggg aaa gcc cat gga gga aac      847
 Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His Gly Gly Asn
     215                 220                 225

 aac aac aaa tac agc acg ttt tct gga ttt att att tat gct gac tga      895
 Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr Ala Asp 
 230                 235                 240

 taatgcagaa actaagctta ttattctgag tttgaacact ggattcgtat ggctaacgtc    955

 agtgaatcaa ggatcccagg ggatgccaat ggcagggcac ctcagttgtg tatatgtggg   1015

 gaaatcaaat gctacctgac tcacatctgt atcactcaga aacattatgt aaaaaatatc   1075

 aaagcaagat aagcagatgt gtgatccact accgccaaag caaatactcc ttatcgttag   1135

 tgtccatgtg aatgaagtcc tatatagatc acaaattttt atagacaaat ctaagacatt   1195

 gaattatttc ttctatatat atgatacttt ggtgtactgt gatcttgctg cttttatcca   1255

 tatgtcagct ttggttcttg tgagtttacc tgcttattat gatacttgga gtccattcat   1315

 agtgtgggga agaatgattt ttgccctgca ggagaaggtc taattgaaat aatgctgctt   1375

 gtccccaaag aaattgtttg ccttgtactc ttgttaacct tagagctaga cctgggaatg   1435

 attcaacttc aagccttaac ctggaatttt ctggatttga gggaattccc aagcctatga   1495

 tctttttcac attttctttt tcttatatga aat                                1528




      <210> 51
      <211> 2121
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(1947)

      <400> 51
 gaattcggca cgaggttagc aataaggctg gagaaggaaa agccggcgcg cccgcggccc     60

 gcgcgatttc ccgccgagcc cgcgtccccg gcggcgggcg ggctccgggg gcgcccgggc    120

 cgcggcggcg cggcggcgcg agctgcgcct ccgggccggt gaatcatccc ggcagacacc    180

 aagagccgcg gcagcagaga ggagcgctga aac atg gct gaa gcg gcc acg ggc     234
                                      Met Ala Glu Ala Ala Thr Gly
                                        1               5

 ttt ctg gag cag ctc aag tcc tgc ata gtt tgg tct tgg acg tat ctg      282
 Phe Leu Glu Gln Leu Lys Ser Cys Ile Val Trp Ser Trp Thr Tyr Leu
          10                  15                  20

 tgg acc gtg tgg ttc ttc atc gtg cta ttc ctg gtc tac atc ctg cgg      330
 Trp Thr Val Trp Phe Phe Ile Val Leu Phe Leu Val Tyr Ile Leu Arg
      25                  30                  35

 gtg cct ttg aaa atc aac gac aac ttg agc aca gtg agc atg ttt ttg      378
 Val Pro Leu Lys Ile Asn Asp Asn Leu Ser Thr Val Ser Met Phe Leu
  40                  45                  50                  55

 aac aca tta aca ccg aag ttc tac gtg gcc cta aca ggc act tcc tca      426
 Asn Thr Leu Thr Pro Lys Phe Tyr Val Ala Leu Thr Gly Thr Ser Ser
                  60                  65                  70

 cta ata tca ggg ctt att ttg ata ttt gaa tgg tgg cat ttt cgc aaa      474
 Leu Ile Ser Gly Leu Ile Leu Ile Phe Glu Trp Trp His Phe Arg Lys
              75                  80                  85

 tac gga act tca ttc att gaa caa gtc tca gta agc cac ttg cgc ccc      522
 Tyr Gly Thr Ser Phe Ile Glu Gln Val Ser Val Ser His Leu Arg Pro
          90                  95                 100

 ctt ctg gga ggg gtt gac aac aac tct tcc aac aat tct aat tcc agt      570
 Leu Leu Gly Gly Val Asp Asn Asn Ser Ser Asn Asn Ser Asn Ser Ser
     105                 110                 115

 aac ggg gac tca gat tcc aat agg caa agt gtc tca gaa tgc aaa gta      618
 Asn Gly Asp Ser Asp Ser Asn Arg Gln Ser Val Ser Glu Cys Lys Val
 120                 125                 130                 135

 tgg cga aat cca cta aat tta ttt agg ggt gct gaa tac aat cgg tat      666
 Trp Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu Tyr Asn Arg Tyr
                 140                 145                 150

 act tgg gtg aca gga cga gag cct ctt act tac tat gac atg aat ctc      714
 Thr Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr Asp Met Asn Leu
             155                 160                 165

 tct gcc caa gac cac cag aca ttc ttt act tgt gac tcg gac cat ctg      762
 Ser Ala Gln Asp His Gln Thr Phe Phe Thr Cys Asp Ser Asp His Leu
         170                 175                 180

 cgt ccc gca gat gca ata atg cag aaa gcc tgg aga gag aga aac ccc      810
 Arg Pro Ala Asp Ala Ile Met Gln Lys Ala Trp Arg Glu Arg Asn Pro
     185                 190                 195

 caa gct agg att tct gca gct cat gaa gcc ttg gag ata aat gag att      858
 Gln Ala Arg Ile Ser Ala Ala His Glu Ala Leu Glu Ile Asn Glu Ile
 200                 205                 210                 215

 agg tcc aga gtt gaa gtt ccc cta att gct tcc tct acc atc tgg gag      906
 Arg Ser Arg Val Glu Val Pro Leu Ile Ala Ser Ser Thr Ile Trp Glu
                 220                 225                 230

 ata aaa ttg tta cca aag tgt gca act gct tat att ctc ttg gct gaa      954
 Ile Lys Leu Leu Pro Lys Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu
             235                 240                 245

 gag gaa gca aca acc att gct gaa gca gaa aaa tta ttt aag cag gcc     1002
 Glu Glu Ala Thr Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala
         250                 255                 260

 ctg aag gct gga gat ggc tgt tac cga cgc tct cag cag cta caa cat     1050
 Leu Lys Ala Gly Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His
     265                 270                 275

 cat gga tcc cag tat gaa gcc caa cat aga cga gac acc aat gtc ttg     1098
 His Gly Ser Gln Tyr Glu Ala Gln His Arg Arg Asp Thr Asn Val Leu
 280                 285                 290                 295

 gtg tac atc aaa aga agg cta gca atg tgt gcc aga aga ctc ggg agg     1146
 Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg Arg Leu Gly Arg
                 300                 305                 310

 acc agg gaa gca gtg aaa atg atg aga gat tta atg aag gag ttc ccc     1194
 Thr Arg Glu Ala Val Lys Met Met Arg Asp Leu Met Lys Glu Phe Pro
             315                 320                 325

 ctt ctg agt atg ttc aat atc cat gaa aac ctt tta gaa gcc ctt ctg     1242
 Leu Leu Ser Met Phe Asn Ile His Glu Asn Leu Leu Glu Ala Leu Leu
         330                 335                 340

 gaa cta caa gca tat gct gat gtt cag gca gtc tta gca aag tat gat     1290
 Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala Lys Tyr Asp
     345                 350                 355

 gat ata agc tta cca aag tca gca aca ata tgc tac aca gct gct ttg     1338
 Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr Ala Ala Leu
 360                 365                 370                 375

 ctc aaa gca aga gct gtc tct gac aaa ttc tct cct gag gct gca tct     1386
 Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu Ala Ala Ser
                 380                 385                 390

 cgg cgg ggg ctg agc aca gca gag atg aat gca gta gag gcc att cat     1434
 Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu Ala Ile His
             395                 400                 405

 aga gct gtg gaa ttc aat cct cat gtg cca aaa tac cta cta gaa atg     1482
 Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu Leu Glu Met
         410                 415                 420

 aaa agc tta atc cta ccc cca gaa cat atc ctg aag aga gga gac agt     1530
 Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg Gly Asp Ser
     425                 430                 435

 gaa gca ata gca tat gca ttc ttt cat ctt gca cac tgg aag aga gtg     1578
 Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp Lys Arg Val
 440                 445                 450                 455

 gaa ggg gct ttg aat ctt ttg cat tgt acg tgg gaa ggc act ttt cgg     1626
 Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly Thr Phe Arg
                 460                 465                 470

 atg atc cct tat ccc ttg gaa aag ggg cac cta ttt tat cct tac cca     1674
 Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr Pro Tyr Pro
             475                 480                 485

 atc tgt aca gaa aca gca gac cga gag ctg ctt cca tct ttc cat gaa     1722
 Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser Phe His Glu
         490                 495                 500

 gtc tca gtt tac cca aag aag gag ctt ccc ttc ttt att ctc ttt act     1770
 Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile Leu Phe Thr
     505                 510                 515

 gct gga tta tgt tcc ttc aca gcc atg ctg gcc ctc ctg aca cat cag     1818
 Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu Thr His Gln
 520                 525                 530                 535

 ttc ccg gaa ctt atg ggg gtc ttc gca aaa gct ttc ctc agc act ttg     1866
 Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Phe Leu Ser Thr Leu
                 540                 545                 550

 ttt gcc ccc tta aac ttt gtc atg gag aaa gtg gag agc atc ctc cca     1914
 Phe Ala Pro Leu Asn Phe Val Met Glu Lys Val Glu Ser Ile Leu Pro
             555                 560                 565

 tcc agt ctg tgg cac cag cta aca cgg atc tga gagaagcc ctgtcctcca     1965
 Ser Ser Leu Trp His Gln Leu Thr Arg Ile 
         570                 575

 ctcacctcac ccgccgctgc caccatctcc tctgtgccaa ctccttgtgg accgcaagaa   2025

 agcatgactt tgaaaaaggg aagccattcc gagattttaa aatgttcatg gactattcca   2085

 tattaaaagc tgtttttgtt gtacaaaaaa aaaaaa                             2121




      <210> 52
      <211> 1970
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (214)..(1797)

      <400> 52
 gaattcggca cgaggttagc aataaggctg gagaaggaaa agccggcgcg cccgcggccc     60

 gcgcgatttc ccgccgagcc cgcgtccccg gcggcgggcg ggctccgggg gcgcccgggc    120

 cgcggcggcg cggcggcgcg agctgcgcct ccgggccggt gaatcatccc ggcagacacc    180

 aagagccgcg gcagcagaga ggagcgctga aac atg gct gaa gcg gcc acg ggc     234
                                      Met Ala Glu Ala Ala Thr Gly
                                        1               5

 ttt ctg gag cag ctc aag tcc tgc ata gtt tgg tct tgg acg tat ctg      282
 Phe Leu Glu Gln Leu Lys Ser Cys Ile Val Trp Ser Trp Thr Tyr Leu
          10                  15                  20

 tgg acc gtg tgg ttc ttc atc gtg cta ttc ctg gtc tac atc ctg cgg      330
 Trp Thr Val Trp Phe Phe Ile Val Leu Phe Leu Val Tyr Ile Leu Arg
      25                  30                  35

 gtg cct ttg aaa atc aac gac aac ttg agc aca gtg agc atg ttt ttg      378
 Val Pro Leu Lys Ile Asn Asp Asn Leu Ser Thr Val Ser Met Phe Leu
  40                  45                  50                  55

 aac aca tta aca ccg aag ttc tac gtg gcc cta aca ggc act tcc tca      426
 Asn Thr Leu Thr Pro Lys Phe Tyr Val Ala Leu Thr Gly Thr Ser Ser
                  60                  65                  70

 cta ata tca ggg ctt att ttg ata ttt gaa tgg tgg cat ttt cgc aaa      474
 Leu Ile Ser Gly Leu Ile Leu Ile Phe Glu Trp Trp His Phe Arg Lys
              75                  80                  85

 tac gga act tca ttc att gaa caa gtc tca gta agc cac ttg cgc ccc      522
 Tyr Gly Thr Ser Phe Ile Glu Gln Val Ser Val Ser His Leu Arg Pro
          90                  95                 100

 ctt ctg gga ggg gtt gac aac aac tct tcc aac aat tct aat tcc agt      570
 Leu Leu Gly Gly Val Asp Asn Asn Ser Ser Asn Asn Ser Asn Ser Ser
     105                 110                 115

 aac ggg gac tca gat tcc aat agg caa agt gtc tca gaa tgc aaa gta      618
 Asn Gly Asp Ser Asp Ser Asn Arg Gln Ser Val Ser Glu Cys Lys Val
 120                 125                 130                 135

 tgg cga aat cca cta aat tta ttt agg ggt gct gaa tac aat cgg tat      666
 Trp Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu Tyr Asn Arg Tyr
                 140                 145                 150

 act tgg gtg aca gga cga gag cct ctt act tac tat gac atg aat ctc      714
 Thr Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr Asp Met Asn Leu
             155                 160                 165

 tct gcc caa gac cac cag aca ttc ttt act tgt gac tcg gac cat ctg      762
 Ser Ala Gln Asp His Gln Thr Phe Phe Thr Cys Asp Ser Asp His Leu
         170                 175                 180

 cgt ccc gca gat gca ata atg cag aaa gcc tgg aga gag aga aac ccc      810
 Arg Pro Ala Asp Ala Ile Met Gln Lys Ala Trp Arg Glu Arg Asn Pro
     185                 190                 195

 caa gct agg att tct gca gct cat gaa gcc ttg gag ata aat gag tgt      858
 Gln Ala Arg Ile Ser Ala Ala His Glu Ala Leu Glu Ile Asn Glu Cys
 200                 205                 210                 215

 gca act gct tat att ctc ttg gct gaa gag gaa gca aca acc att gct      906
 Ala Thr Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Ala
                 220                 225                 230

 gaa gca gaa aaa tta ttt aag cag gcc ctg aag gct gga gat ggc tgt      954
 Glu Ala Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly Asp Gly Cys
             235                 240                 245

 tac cga cgc tct cag cag cta caa cat cat gga tcc cag tat gaa gcc     1002
 Tyr Arg Arg Ser Gln Gln Leu Gln His His Gly Ser Gln Tyr Glu Ala
         250                 255                 260

 caa cat aga cga gac acc aat gtc ttg gtg tac atc aaa aga agg cta     1050
 Gln His Arg Arg Asp Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu
     265                 270                 275

 gca atg tgt gcc aga aga ctc ggg agg acc agg gaa gca gtg aaa atg     1098
 Ala Met Cys Ala Arg Arg Leu Gly Arg Thr Arg Glu Ala Val Lys Met
 280                 285                 290                 295

 atg aga gat tta atg aag gag ttc ccc ctt ctg agt atg ttc aat atc     1146
 Met Arg Asp Leu Met Lys Glu Phe Pro Leu Leu Ser Met Phe Asn Ile
                 300                 305                 310

 cat gaa aac ctt tta gaa gcc ctt ctg gaa cta caa gca tat gct gat     1194
 His Glu Asn Leu Leu Glu Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp
             315                 320                 325

 gtt cag gca gtc tta gca aag tat gat gat ata agc tta cca aag tca     1242
 Val Gln Ala Val Leu Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser
         330                 335                 340

 gca aca ata tgc tac aca gct gct ttg ctc aaa gca aga gct gtc tct     1290
 Ala Thr Ile Cys Tyr Thr Ala Ala Leu Leu Lys Ala Arg Ala Val Ser
     345                 350                 355

 gac aaa ttc tct cct gag gct gca tct cgg cgg ggg ctg agc aca gca     1338
 Asp Lys Phe Ser Pro Glu Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala
 360                 365                 370                 375

 gag atg aat gca gta gag gcc att cat aga gct gtg gaa ttc aat cct     1386
 Glu Met Asn Ala Val Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro
                 380                 385                 390

 cat gtg cca aaa tac cta cta gaa atg aaa agc tta atc cta ccc cca     1434
 His Val Pro Lys Tyr Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro
             395                 400                 405

 gaa cat atc ctg aag aga gga gac agt gaa gca ata gca tat gca ttc     1482
 Glu His Ile Leu Lys Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe
         410                 415                 420

 ttt cat ctt gca cac tgg aag aga gtg gaa ggg gct ttg aat ctt ttg     1530
 Phe His Leu Ala His Trp Lys Arg Val Glu Gly Ala Leu Asn Leu Leu
     425                 430                 435

 cat tgt acg tgg gaa ggc act ttt cgg atg atc cct tat ccc ttg gaa     1578
 His Cys Thr Trp Glu Gly Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu
 440                 445                 450                 455

 aag ggg cac cta ttt tat cct tac cca atc tgt aca gaa aca gca gac     1626
 Lys Gly His Leu Phe Tyr Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp
                 460                 465                 470

 cga gag ctg ctt cca tct atg ctg gcc ctc ctg aca cat cag ttc ccg     1674
 Arg Glu Leu Leu Pro Ser Met Leu Ala Leu Leu Thr His Gln Phe Pro
             475                 480                 485

 gaa ctt atg ggg gtc ttc gca aaa gct ttc ctc agc act ttg ttt gcc     1722
 Glu Leu Met Gly Val Phe Ala Lys Ala Phe Leu Ser Thr Leu Phe Ala
         490                 495                 500

 ccc tta aac ttt gtc atg gag aaa gtg gag agc atc ctc cca tcc agt     1770
 Pro Leu Asn Phe Val Met Glu Lys Val Glu Ser Ile Leu Pro Ser Ser
     505                 510                 515

 ctg tgg cac cag cta aca cgg atc tga gagaa gccctgtcct ccactcacct     1822
 Leu Trp His Gln Leu Thr Arg Ile 
 520                 525

 cacccgccgc tgccaccatc tcctctgtgc caactccttg tggaccgcaa gaaagcatga   1882

 ctttgaaaaa gggaagccat tccgagattt taaaatgttc atggactatt ccatattaaa   1942

 agctgttttt gttgtacaaa aaaaaaaa                                      1970




      <210> 53
      <211> 2568
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (808)..(2514)

      <400> 53
 tgagaatagt ttgacctctg atcaccaaaa aacctggagg ataaacattc atctgtcaag     60

 atttctctgg aaaatccctg cgctgcttca aagagacaga acaaaggtaa atagcatctg    120

 ccacccaaat cttgctgaat agagtgattt atcttcaggc ctactagccg gcgacaggag    180

 cgcacctcct cccttctcct agctgtcccg ggtttattca ttccctgagc ctgaatcctg    240

 ataagggagc agagtagggt ttaagacctc ggaccccaga atacaccact gcaattgaat    300

 tttggttcca ccttaaggta aactacgcag ctgctgtgag cctcagtttc cctacctata    360

 gaaagaggat cgtagtgggg aattgttgca ggggttaaat gagattgtac ggatcgtgga    420

 gcagcgcctg gcgtgtggta aacgctcaac ttaagcgggt tgtaactgcc tgaggcgttt    480

 ccttcggcgc gccacttggc cttctctttc taaatattag cataataaat ataaatggac    540

 ccagaacgcg agggggcagg ggccacgtga tcgctccacg aaagccactt gtagggacct    600

 ttagagagtt agcaataagg ctggagaagg aaaagccggc gcgcccgcgg cccgcgcgat    660

 ttcccgccga gcccgcgtcc ccggcggcgg gcgggctccg ggggcgcccg ggccgcggcg    720

 gcgcggcggc gcgagctgcg cctcccgggc cggtgaatca tcccggcaga caccaagagc    780

 cgcggcagca gagaggagcg ctgaaac    atg gct gaa gcg gcc acg ggc ttt     831
                                  Met Ala Glu Ala Ala Thr Gly Phe
                                    1               5

 ctg gag cag ctc aag tcc tgc ata gtt tgg tct tgg acg tat ctg tgg      879
 Leu Glu Gln Leu Lys Ser Cys Ile Val Trp Ser Trp Thr Tyr Leu Trp
      10                  15                  20

 acc gtg tgg ttc ttc atc gtg cta ttc ctg gtc tac atc ctg cgg gtg      927
 Thr Val Trp Phe Phe Ile Val Leu Phe Leu Val Tyr Ile Leu Arg Val
  25                  30                  35                  40

 cct ttg aaa atc aac gac aac ttg agc aca gtg agc atg ttt ttg aac      975
 Pro Leu Lys Ile Asn Asp Asn Leu Ser Thr Val Ser Met Phe Leu Asn
                  45                  50                  55

 aca tta aca ccg aag ttc tac gtg gcc cta aca ggc act tcc tca cta     1023
 Thr Leu Thr Pro Lys Phe Tyr Val Ala Leu Thr Gly Thr Ser Ser Leu
              60                  65                  70

 ata tca ggg ctt att ttg ata ttt gaa tgg tgg tat ttt cgc aaa tac     1071
 Ile Ser Gly Leu Ile Leu Ile Phe Glu Trp Trp Tyr Phe Arg Lys Tyr
          75                  80                  85

 gga act tca ttc att gaa caa gtc tca gta agc cac ttg cgc ccc ctt     1119
 Gly Thr Ser Phe Ile Glu Gln Val Ser Val Ser His Leu Arg Pro Leu
      90                  95                 100

 ctg gga ggg gtt gac aac aac tct tcc aac aat tct aat tcc agt aac     1167
 Leu Gly Gly Val Asp Asn Asn Ser Ser Asn Asn Ser Asn Ser Ser Asn
 105                 110                 115                 120

 ggg gac tca gat tcc aat agg caa agt gtc tca gaa tgc aaa gta tgg     1215
 Gly Asp Ser Asp Ser Asn Arg Gln Ser Val Ser Glu Cys Lys Val Trp
                 125                 130                 135

 cga aat cca cta aat tta ttt agg ggt gct gaa tac aat cgg tat act     1263
 Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu Tyr Asn Arg Tyr Thr
             140                 145                 150

 tgg gtg aca gga cga gag cct ctt act tac tat gac atg aat ctc tct     1311
 Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr Asp Met Asn Leu Ser
         155                 160                 165

 gcc caa gac cac cag aca ttc ttt act tgt gac tcg gac cat ctg cgt     1359
 Ala Gln Asp His Gln Thr Phe Phe Thr Cys Asp Ser Asp His Leu Arg
     170                 175                 180

 ccc gca gat gca ata atg cag aaa gcc tgg aga gag aga aac ccc caa     1407
 Pro Ala Asp Ala Ile Met Gln Lys Ala Trp Arg Glu Arg Asn Pro Gln
 185                 190                 195                 200

 gct agg att tct gca gct cat gaa gcc ttg gag ata aat gaa att agg     1455
 Ala Arg Ile Ser Ala Ala His Glu Ala Leu Glu Ile Asn Glu Ile Arg
                 205                 210                 215

 tcc aga gtt gaa gtt ccc cta att gct tcc tct acc atc tgg gag ata     1503
 Ser Arg Val Glu Val Pro Leu Ile Ala Ser Ser Thr Ile Trp Glu Ile
             220                 225                 230

 aaa ttg tta cca aag tgt gca act gct tat att ctc ttg gct gaa gag     1551
 Lys Leu Leu Pro Lys Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu Glu
         235                 240                 245

 gaa gca aca acc att gct gaa gca gaa aaa tta ttt aag cag gcc ctg     1599
 Glu Ala Thr Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala Leu
     250                 255                 260

 aag gct gga gat ggc tgt tac cga cgc tct cag cag cta caa cat cat     1647
 Lys Ala Gly Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His His
 265                 270                 275                 280

 gga tcc cag tat gaa gcc caa cat aga cga gac acc aat gtc ttg gtg     1695
 Gly Ser Gln Tyr Glu Ala Gln His Arg Arg Asp Thr Asn Val Leu Val
                 285                 290                 295

 tac atc aaa aga agg cta gca atg tgt gcc aga aga ctc ggg agg acc     1743
 Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg Arg Leu Gly Arg Thr
             300                 305                 310

 agg gaa gca gtg aaa atg atg aga gat tta atg aag gag ttc ccc ctt     1791
 Arg Glu Ala Val Lys Met Met Arg Asp Leu Met Lys Glu Phe Pro Leu
         315                 320                 325

 ctg agt atg ttc aat atc cat gaa aac ctt tta gaa gcc ctt ctg gaa     1839
 Leu Ser Met Phe Asn Ile His Glu Asn Leu Leu Glu Ala Leu Leu Glu
     330                 335                 340

 cta caa gca tat gct gat gtt cag gca gtc tta gca aag tat gat gat     1887
 Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala Lys Tyr Asp Asp
 345                 350                 355                 360

 ata agc tta cca aag tca gca aca ata tgc tac aca gct gct ttg ctc     1935
 Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr Ala Ala Leu Leu
                 365                 370                 375

 aaa gca aga gct gtc tct gac aaa ttc tct cct gag gct gca tct cgg     1983
 Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu Ala Ala Ser Arg
             380                 385                 390

 cgg ggg ctg agc aca gca gag atg aat gca gta gag gcc att cat aga     2031
 Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu Ala Ile His Arg
         395                 400                 405

 gct gtg gaa ttc aat cct cat gtg cca aaa tac cta cta gaa atg aaa     2079
 Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu Leu Glu Met Lys
     410                 415                 420

 agc tta atc cta ccc cca gaa cat atc ctg aag aga gga gac agt gaa     2127
 Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg Gly Asp Ser Glu
 425                 430                 435                 440

 gca ata gca tat gca ttc ttt cat ctt gca cac tgg aag aga gtg gaa     2175
 Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp Lys Arg Val Glu
                 445                 450                 455

 ggg gct ttg aat ctt ttg cat tgt acg tgg gaa ggc act ttt cgg atg     2223
 Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly Thr Phe Arg Met
             460                 465                 470

 atc cct tat ccc ttg gaa aag ggg cac cta ttt tat cct tac cca atc     2271
 Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr Pro Tyr Pro Ile
         475                 480                 485

 tgt aca gaa aca gca gac cga gag ctg ctt cca tct ttc cat gaa gtc     2319
 Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser Phe His Glu Val
     490                 495                 500

 tca gtt tac cca aag aag gag ctt ccc ttc ttt att ctc ttt act gct     2367
 Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile Leu Phe Thr Ala
 505                 510                 515                 520

 gga tta tgt tcc ttc aca gcc atg ctg gcc ctc ctg aca cat cag ttc     2415
 Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu Thr His Gln Phe
                 525                 530                 535

 ccg gaa ctt atg ggg gtc ttc gca aaa gct gtg agt gtt tgc cta gag     2463
 Pro Glu Leu Met Gly Val Phe Ala Lys Ala Val Ser Val Cys Leu Glu
             540                 545                 550

 gga ggc ctt ggg gaa tgg atg ggg aaa gcc aag ggc ata aaa gca gcg     2511
 Gly Gly Leu Gly Glu Trp Met Gly Lys Ala Lys Gly Ile Lys Ala Ala
         555                 560                 565

 tga gatg aactggaaat ccctccggca cctcaatctc aacatttcca aaactgaact     2568
 






      <210> 54
      <211> 1231
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (596)..(1189)

      <400> 54
 gcggggagaa tggtggctgc ttttgaattt cctgactctg gtggcttcac tgtcacatct     60

 atggggtgta aagggaggaa gagtgtcgag ttttgtgcca tgaacagatt ccgtttctgc    120

 agaggacagc gtgcagggga cacccttcga ggctttggag ccacctagga agcaggctgg    180

 ctgctgcaca ggcctctgct ggcctccttg cacatgtcct tggtgggtga ggcagccacg    240

 tgagatggct tccggcactg ctggcgtgag tagccttcct ggcaatgcca gctcttgccg    300

 tcctcacctc ctggccccag tggcccgcat gacgctctct gttctacaca gccctcctgg    360

 tcttcagtgc cctgggaaac atccttgccc tttgccttac ctgtcaaaag agcaggaaga    420

 tcaactgcac aggcatctac ctggtgcacc tggctgtgtc tgacctgctg ttcaccgtgg    480

 ccttaccggg aagggtggtg tgttatgtgc tgggctccag ctggcctttc ggcaaggggc    540

 tctgcaggct gacggcgttt gtgctctaca ccgacaccta cggggggtct acctc atg     598
                                                              Met
                                                                1

 gcc tgt gtg agc gtg gac cat tac cca gct gtg gtc tgt gcc cac tgg      646
 Ala Cys Val Ser Val Asp His Tyr Pro Ala Val Val Cys Ala His Trp
               5                  10                  15

 ggc ccg tgc ctc cgc acg gct ggc cgc gcc agg ctg gtc tgc gtg gcc      694
 Gly Pro Cys Leu Arg Thr Ala Gly Arg Ala Arg Leu Val Cys Val Ala
          20                  25                  30

 atc tgg acc ttg gtg ctg ctg cag acg atg ccc ttg ctc ttg atg ccc      742
 Ile Trp Thr Leu Val Leu Leu Gln Thr Met Pro Leu Leu Leu Met Pro
      35                  40                  45

 atg acc aag ccg ctg gtg ggc aag ctg gcc tgc atg gag tac agc agc      790
 Met Thr Lys Pro Leu Val Gly Lys Leu Ala Cys Met Glu Tyr Ser Ser
  50                  55                  60                  65

 atg gag tca gtc ctc ggg ctg ccc ctc atg gtc ctg gtg gcc ttt gcc      838
 Met Glu Ser Val Leu Gly Leu Pro Leu Met Val Leu Val Ala Phe Ala
                  70                  75                  80

 att ggc ttc tgt ggg cca gtg ggg atc atc ctg tcc tgc tat atg aag      886
 Ile Gly Phe Cys Gly Pro Val Gly Ile Ile Leu Ser Cys Tyr Met Lys
              85                  90                  95

 atc acc tgg aag ctg tgc agc aca gct gac cca gtg acc agc agg aaa      934
 Ile Thr Trp Lys Leu Cys Ser Thr Ala Asp Pro Val Thr Ser Arg Lys
         100                 105                 110

 gga cgc cac tgg cga ggc tgc ctg ctt acg ctg ctg atg ctg gtg gcc      982
 Gly Arg His Trp Arg Gly Cys Leu Leu Thr Leu Leu Met Leu Val Ala
     115                 120                 125

 gtg gtg gtc tgc ttc agc ccc tac cac ctc aac atc aag cag ttc atg     1030
 Val Val Val Cys Phe Ser Pro Tyr His Leu Asn Ile Lys Gln Phe Met
 130                 135                 140                 145

 gcg aga ggg atg ctc cac ctg cca tcc tgt gcc gag cgg agg gct ttc     1078
 Ala Arg Gly Met Leu His Leu Pro Ser Cys Ala Glu Arg Arg Ala Phe
                 150                 155                 160

 tta ctg tcc ctt cag gcc acc gtg gcc ctc atg aac atg aac tgt ggc     1126
 Leu Leu Ser Leu Gln Ala Thr Val Ala Leu Met Asn Met Asn Cys Gly
             165                 170                 175

 att acc cca tca ttt act tct ttg cat cca ccc att aca gga aat ggc     1174
 Ile Thr Pro Ser Phe Thr Ser Leu His Pro Pro Ile Thr Gly Asn Gly
         180                 185                 190

 tcc tgg gca ttt taa agctcaaagg gtcttcctcc tcctcctcct cctcctccac     1229
 Ser Trp Ala Phe 
     195

 ct                                                                  1231




      <210> 55
      <211> 3846
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (191)..(3340)

      <400> 55
 gcgagaggta gctgtccggg tggggagccc gcactacctt cttcctcttc ctcctcctcc     60

 tccgggtgag gggagcgaag gttgggggtc cccgagccca tggaccagga ggaggcggag    120

 gccgccgaga gccggggccc cgctatgtgg ccctgagccc cgtgtactgg ttctgcctgt    180

 ctggagggcc   atg gag aag agg ctg gga gtc aag cca aat cct gct tcc     229
              Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser
                1               5                  10

 tgg att tta tca gga tat tat tgg cag aca tct gcg aag tgg ttg aga      277
 Trp Ile Leu Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg
      15                  20                  25

 agc ctg tac ctg ttt tat act tgc ttt tgc ttc agc gtt ctg tgg ttg      325
 Ser Leu Tyr Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu
  30                  35                  40                  45

 tca aca gat gcc agt gag agc agg tgc cag cag ggg aag aca caa ttt      373
 Ser Thr Asp Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe
                  50                  55                  60

 gga gtt ggc ctg aga tct ggg gga gaa aat cac ctc tgg ctt ctt gaa      421
 Gly Val Gly Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu
              65                  70                  75

 gga acc ccc tct ctc cag tca tgt tgg gct gcc tgc tgc cag gac tct      469
 Gly Thr Pro Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser
          80                  85                  90

 gcc tgc cat gtc ttt tgg tgg cta gaa ggg atg tgc att cag gca gac      517
 Ala Cys His Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp
      95                 100                 105

 tgc agc agg ccc cag agc tgc cgg gct ttt agg aca cac tcc tcc aat      565
 Cys Ser Arg Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn
 110                 115                 120                 125

 tcc atg ctg gtg ttt tta aaa aaa ttc caa act gca gat gat ttg ggc      613
 Ser Met Leu Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly
                 130                 135                 140

 ttt cta cct gaa gat gat gta cca cat ctt ctg ggg cta ggt tgg aac      661
 Phe Leu Pro Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn
             145                 150                 155

 tgg gca tct tgg agg cag agc cca ccc aga gct gca ctc aga cct gct      709
 Trp Ala Ser Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala
         160                 165                 170

 gta tct tcc agt gac cag cag agc tta atc agg aag ctt cag aag aga      757
 Val Ser Ser Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg
     175                 180                 185

 ggt agt ccc agt gac gta gtt aca cct ata gtg aca cag cat tct aaa      805
 Gly Ser Pro Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys
 190                 195                 200                 205

 gtg aat gac tcc aac gaa tta ggt ggt ctg act acc agt ggc tct gca      853
 Val Asn Asp Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala
                 210                 215                 220

 gag gtc cac aag gcg att aca att tcc agt ccc cta acc aca gac ctg      901
 Glu Val His Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu
             225                 230                 235

 act gca gag ctg tct ggt ggg cca aag aat gta tca gtg caa cct gaa      949
 Thr Ala Glu Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu
         240                 245                 250

 ata tca gag ggt ctt gct act acg ccc agc act caa caa gta aaa agt      997
 Ile Ser Glu Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser
     255                 260                 265

 tct gag aaa acc cag att gct gtc ccc cag cca gtg gct ccc tcc tac     1045
 Ser Glu Lys Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr
 270                 275                 280                 285

 agt tat gct acc cct acc ccc cag gcc tct ttc cag agc acc tca gca     1093
 Ser Tyr Ala Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala
                 290                 295                 300

 cca tac cca gtt ata aag gaa ctg gtg gta tct gct gga gag agt gtc     1141
 Pro Tyr Pro Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val
             305                 310                 315

 cag ata acc ctg cct aag aat gaa gtt caa tta aat gca tat gtt ctc     1189
 Gln Ile Thr Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu
         320                 325                 330

 caa gaa cca cct aaa gga gaa acc tac acc tac gac tgg cag ctg att     1237
 Gln Glu Pro Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile
     335                 340                 345

 act cat cct aga gac tac agt gga gaa atg gaa ggg aaa cat tcc cag     1285
 Thr His Pro Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln
 350                 355                 360                 365

 atc ctc aaa cta tcg aag ctc act cca ggc ctg tat gaa ttc aaa gtg     1333
 Ile Leu Lys Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val
                 370                 375                 380

 att gta gag ggt caa aat gcc cat ggg gaa ggc tat gtg aac gtg aca     1381
 Ile Val Glu Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr
             385                 390                 395

 gtc aag cca gag ccc cgt aag aat cgg ccc ccc att gct att gtg tca     1429
 Val Lys Pro Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser
         400                 405                 410

 cct cag ttc cag gag atc tct ttg cca acc act tct aca gtc att gat     1477
 Pro Gln Phe Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp
     415                 420                 425

 ggc agt caa agc act gat gat gat aaa atc gtt cag tac cat tgg gaa     1525
 Gly Ser Gln Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu
 430                 435                 440                 445

 gaa ctt aag ggg cct cta aga gaa gag aag att tct gaa gat aca gcc     1573
 Glu Leu Lys Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala
                 450                 455                 460

 ata tta aaa cta agt aaa ctc gtc cct ggg aac tac act ttc agc ttg     1621
 Ile Leu Lys Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu
             465                 470                 475

 act gta gta gac tct gat gga gct acc aac tct act act gca aac ctg     1669
 Thr Val Val Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu
         480                 485                 490

 aca gtg aac aaa gct gtg gat tac ccc cct gtg gcc aac gca ggc ccc     1717
 Thr Val Asn Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro
     495                 500                 505

 aac caa gtg atc acc ctg ccc caa aac tcc atc acc ctc ttt ggg aac     1765
 Asn Gln Val Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn
 510                 515                 520                 525

 cag agc act gat gat cat ggc atc acc agc tat gag tgg tca ctc agc     1813
 Gln Ser Thr Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser
                 530                 535                 540

 cca agc agc aaa ggg aaa gtg gtg gag atg cag ggt gtt aga aca cca     1861
 Pro Ser Ser Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro
             545                 550                 555

 acc tta cag ctc tct gcg atg caa gaa gga gac tac act tac cag ctc     1909
 Thr Leu Gln Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu
         560                 565                 570

 aca gtg act gac aca ata gga cag cag gcc act gct caa gtg act gtt     1957
 Thr Val Thr Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val
     575                 580                 585

 att gtg caa cct gaa aac aat aag cct cct cag gca gat gca ggc cca     2005
 Ile Val Gln Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro
 590                 595                 600                 605

 gat aaa gag ctg acc ctt cct gtg gat agc aca acc ctg gat ggc agc     2053
 Asp Lys Glu Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser
                 610                 615                 620

 aag agc tca gat gat cag aaa att atc tca tat ctc tgg gaa aaa aca     2101
 Lys Ser Ser Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr
             625                 630                 635

 cag gga cct gat ggg gtg cag ctc gag aat gct aac agc agt gtt gct     2149
 Gln Gly Pro Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala
         640                 645                 650

 act gtg act ggg ctg caa gtg ggg acc tat gtg ttc acc ttg act gtc     2197
 Thr Val Thr Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val
     655                 660                 665

 aaa gat gag agg aac ctg caa agc cag agc tct gtg aat gtc att gtc     2245
 Lys Asp Glu Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val
 670                 675                 680                 685

 aaa gaa gaa ata aac aaa cca cct ata gcc aag ata act ggg aat gtg     2293
 Lys Glu Glu Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val
                 690                 695                 700

 gtg att acc cta ccc acg agc aca gca gag ctg gat ggc tct aag tcc     2341
 Val Ile Thr Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser
             705                 710                 715

 tca gat gac aag gga ata gtc agc tac ctc tgg act cga gat gag ggg     2389
 Ser Asp Asp Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly
         720                 725                 730

 agc cca gca gca ggg gag gtg tta aat cac tct gac cat cac cct atc     2437
 Ser Pro Ala Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile
     735                 740                 745

 ctt ttt ctt tca aac ctg gtt gag gga acc tac act ttt cac ctg aaa     2485
 Leu Phe Leu Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys
 750                 755                 760                 765

 gtg acc gat gca aag ggt gag agt gac aca gac cgg acc act gtg gag     2533
 Val Thr Asp Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu
                 770                 775                 780

 gtg aaa cct gat ccc agg aaa aac aac ctg gtg gag atc atc ttg gat     2581
 Val Lys Pro Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp
             785                 790                 795

 atc aac gtc agt cag cta act gag agg ctg aag ggg atg ttc atc cgc     2629
 Ile Asn Val Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg
         800                 805                 810

 cag att ggg gtc ctc ctg ggg gtg ctg gat tcc gac atc att gtg caa     2677
 Gln Ile Gly Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln
     815                 820                 825

 aag att cag ccg tac acg gag cag agc acc aaa atg gta ttt ttt gtt     2725
 Lys Ile Gln Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val
 830                 835                 840                 845

 caa aac gag cct ccc cac cag atc ttc aaa ggc cat gag gtg gca gcg     2773
 Gln Asn Glu Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala
                 850                 855                 860

 atg ctc aag agt gag ctg cgg aag caa aag gca gac ttt ttg ata ttc     2821
 Met Leu Lys Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe
             865                 870                 875

 aga gcc ttg gaa gtc aac act gtc aca tgt cag ctg aac tgt tcc gac     2869
 Arg Ala Leu Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp
         880                 885                 890

 cat ggc cac tgt gac tcg ttc acc aaa cgc tgt atc tgt gac cct ttt     2917
 His Gly His Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe
     895                 900                 905

 tgg atg gag aat ttc atc aag gtg cag ctg agg gat gga gac agc aac     2965
 Trp Met Glu Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn
 910                 915                 920                 925

 tgt gag tgg agc gtg tta tat gtt atc att gct acc ttt gtc att gtt     3013
 Cys Glu Trp Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val
                 930                 935                 940

 gtt gcc ttg gga atc ctg tct tgg act gtg atc tgt tgt tgt aag agg     3061
 Val Ala Leu Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg
             945                 950                 955

 caa aaa gga aaa ccc aag agg aaa agc aag tac aag atc ctg gat gcc     3109
 Gln Lys Gly Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala
         960                 965                 970

 acg gat cag gaa agc ctg gag ctg aag cca acc tcc cga gca ggc atc     3157
 Thr Asp Gln Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile
     975                 980                 985

 aaa cag aaa ggc ctt ttg cta agt agc agc ctg atg cac tcc gag tca     3205
 Lys Gln Lys Gly Leu Leu Leu Ser Ser Ser Leu Met His Ser Glu Ser
 990                 995                1000                1005

 gag ctg gac agc gat gat gcc atc ttt aca tgg cca gac cga gag aag     3253
 Glu Leu Asp Ser Asp Asp Ala Ile Phe Thr Trp Pro Asp Arg Glu Lys
                1010                1015                1020

 ggc aaa ctc ctg cat ggt cag aat ggc tct gta ccc aac ggg cag acc     3301
 Gly Lys Leu Leu His Gly Gln Asn Gly Ser Val Pro Asn Gly Gln Thr
            1025                1030                1035

 cct ctg aag gcc agg agc ccg cgg gag gag atc ctg tag ccacctggtc      3350
 Pro Leu Lys Ala Arg Ser Pro Arg Glu Glu Ile Leu 
        1040                1045

 tgtctcctca gggcagggcc cagcacactg cccggccagt cctcctacct cccgagtctg   3410

 cgggcagctg ctgtcccagc atctgctggt catttcgccc tgacagtccc aaccagaacc   3470

 cctgggactt gaatccagag acgtcctcca ggaacccctc aacgaagctg tgaatgaaga   3530

 ggtttcctct ttaaacctgt ctggtgggcc cccagatatc ctcacctcag ggcctccttt   3590

 ttttgcaaac tcctcccctc ccccgagggc agacccagcc agctgctaag ctctgcagct   3650

 ccccagtgga cagtgtcatt gtgcccagag tgctgcaagg tgaggcctgc tgtgctgccc   3710

 gcacacctga gtgcaaaacc aagcactgtg ggcatggtgt ttccctctct ggggtagagt   3770

 acgccctctc gctgggcaaa gaggaagtgg cacccctccc ctcaccacag atgctgagat   3830

 ggtagcatag aaatga                                                   3846




      <210> 56
      <211> 1136
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(671)

      <400> 56
 ggctgcatag gagctgcagc gcggtgcggc cagcacacac cccggcccgc gaggccccgg     60

 gctcgccc atg agg cct ctg ccc agc ggg agg agg aag acc cga ggc atc     110
          Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile
            1               5                  10

 tcc cta gga ctc ttc gcc ctc tgc ctg gcc gca gcc cgc tgt ctg cag      158
 Ser Leu Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln
  15                  20                  25                  30

 agt cag ggt gtg tcc cta tac att cct cag gcc acc atc aat gcc act      206
 Ser Gln Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr
                  35                  40                  45

 gtc aaa gaa gac atc ctg ctc tca gtt gag tac tcc tgt cat gga gtg      254
 Val Lys Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val
              50                  55                  60

 ccc acc atc gaa tgg aca tat tca tcc aat tgg gga acg cag aag atc      302
 Pro Thr Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile
          65                  70                  75

 gtg gag tgg aaa cca ggg act cag gcc aac atc tct caa agc cac aag      350
 Val Glu Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys
      80                  85                  90

 gac aga gtc tgc acc ttt gac aac ggc tcc atc cag ctc ttc agc gtg      398
 Asp Arg Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val
  95                 100                 105                 110

 gga gtg agg gat tcc ggc tac tat gtc atc acc gtg acg gag cgc ctg      446
 Gly Val Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu
                 115                 120                 125

 ggg agc agc cag ttt ggc acc atc gtg ctg cac gtc tct gag atc ctc      494
 Gly Ser Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu
             130                 135                 140

 tat gaa gac ctg cac ttt gtc gct gtc atc ctt gct ttt ctc gct gct      542
 Tyr Glu Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala
         145                 150                 155

 gtg gcc gca gta tta atc agc ctc atg tgg gtt tgt aat aag tgt gca      590
 Val Ala Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala
     160                 165                 170

 tat aaa ttt cag agg aag aga aga cac aaa ctc aaa gaa agc aca act      638
 Tyr Lys Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser Thr Thr
 175                 180                 185                 190

 gag gag att gag ctg gaa gat gtt gag tgt tag ccaaggct gggcctgact      689
 Glu Glu Ile Glu Leu Glu Asp Val Glu Cys 
                 195                 200

 gcattcctac ctcaagagga aaccattctc caacaaaaag agcaagcaca gctattatac    749

 ccattgtgtg tggtcctgtt gcagcccgct cctaacagga cagtgggaga ttaacaacat    809

 tgactgcatg gagttgagga ctgtggatgg gacaaagcta gtattaggac tcgcgctaag    869

 ttcaaggaga agagtgattg aggctttgaa ccaggagctc cgcttggctg cagcatcagg    929

 gccgtgctga cacataacca atgggtgagt gcaggcgttg gctgcttgct cacgacactt    989

 gctctggtgt gcaggatggc ctgttgtcag agtccctgta tcagaggcca gaggatttcc   1049

 agatggatgt gcagccagca ttagaacatg ctttctgtgc tcctgtctgc tctgcaactg   1109

 ctgtgccaac cagcccccca tctggta                                       1136




      <210> 57
      <211> 1537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(1154)

      <400> 57
 ggacgtcaat ccgagctcgt cccggcctca ccagcgcc    atg ctg ggc tcg cga      53
                                              Met Leu Gly Ser Arg
                                                1               5

 gcc gcg ggg ttc gcg cgg ggc ctg cgg gct gtg gca ctg gcg tgg ctg      101
 Ala Ala Gly Phe Ala Arg Gly Leu Arg Ala Val Ala Leu Ala Trp Leu
                  10                  15                  20

 ccg ggc tgg cgg ggc cgc tcc ttc gcc ctg gcg cgt gcg gca ggc gcg      149
 Pro Gly Trp Arg Gly Arg Ser Phe Ala Leu Ala Arg Ala Ala Gly Ala
              25                  30                  35

 ccc cac ggt ggt gac ttg cag ccc ccc gcc tgt ccc gag ccg cgc ggg      197
 Pro His Gly Gly Asp Leu Gln Pro Pro Ala Cys Pro Glu Pro Arg Gly
          40                  45                  50

 cgc cag ctc agt ttg tcc gcg gcg gcg gtg gtg gac tct gcg ccc cgc      245
 Arg Gln Leu Ser Leu Ser Ala Ala Ala Val Val Asp Ser Ala Pro Arg
      55                  60                  65

 ccc ctg cag ccg tac ttg cgc ctc atg cgg ttg gac aag ccc att gga      293
 Pro Leu Gln Pro Tyr Leu Arg Leu Met Arg Leu Asp Lys Pro Ile Gly
  70                  75                  80                  85

 acc tgg ctt ctg tat tta cca tgt acc tgg agc att ggt ttg gca gct      341
 Thr Trp Leu Leu Tyr Leu Pro Cys Thr Trp Ser Ile Gly Leu Ala Ala
                  90                  95                 100

 gaa cca ggt tgt ttt cca gat tgg tac atg ctc tcc ctc ttt ggc act      389
 Glu Pro Gly Cys Phe Pro Asp Trp Tyr Met Leu Ser Leu Phe Gly Thr
             105                 110                 115

 gga gct att ctg atg cgt gga gca ggc tgt act att aat gac atg tgg      437
 Gly Ala Ile Leu Met Arg Gly Ala Gly Cys Thr Ile Asn Asp Met Trp
         120                 125                 130

 gac cag gac tat gat aaa aag gtt aca aga aca gcc aat cgt cca ata      485
 Asp Gln Asp Tyr Asp Lys Lys Val Thr Arg Thr Ala Asn Arg Pro Ile
     135                 140                 145

 gcc gct gga gac att tca act ttt cag tcc ttt gtt ttt ctt ggg gga      533
 Ala Ala Gly Asp Ile Ser Thr Phe Gln Ser Phe Val Phe Leu Gly Gly
 150                 155                 160                 165

 cag cta acc ctg gca ctg ggt gtt ctt ctg tgt cta aat tac tac agt      581
 Gln Leu Thr Leu Ala Leu Gly Val Leu Leu Cys Leu Asn Tyr Tyr Ser
                 170                 175                 180

 ata gct ctg gga gca gga tcc tta ctt ctt gtc atc acc tac cca cta      629
 Ile Ala Leu Gly Ala Gly Ser Leu Leu Leu Val Ile Thr Tyr Pro Leu
             185                 190                 195

 atg aaa aga att tca tac tgg cct caa cta gcc ttg ggc ttg aca ttt      677
 Met Lys Arg Ile Ser Tyr Trp Pro Gln Leu Ala Leu Gly Leu Thr Phe
         200                 205                 210

 aat tgg gga gcg tta ctt gga tgg tct gct atc aag ggt tcc tgt gat      725
 Asn Trp Gly Ala Leu Leu Gly Trp Ser Ala Ile Lys Gly Ser Cys Asp
     215                 220                 225

 cca tct gtt tgc ctg cct ctt tat ttt tct gga gtt atg tgg aca cta      773
 Pro Ser Val Cys Leu Pro Leu Tyr Phe Ser Gly Val Met Trp Thr Leu
 230                 235                 240                 245

 ata tat gac act att tat gcc cat cag gac aaa aga gat gat gtt ttg      821
 Ile Tyr Asp Thr Ile Tyr Ala His Gln Asp Lys Arg Asp Asp Val Leu
                 250                 255                 260

 att ggt ctt aag tca acg gct ctg cgg ttc gga gaa aat acc aag ccg      869
 Ile Gly Leu Lys Ser Thr Ala Leu Arg Phe Gly Glu Asn Thr Lys Pro
             265                 270                 275

 tgg ctc agc ggc ttc agt gtt gca atg ctg ggg gca ctg agc cta gtg      917
 Trp Leu Ser Gly Phe Ser Val Ala Met Leu Gly Ala Leu Ser Leu Val
         280                 285                 290

 ggt gtg aac agt gga cag act gct ccc tac tac gct gcc ctg ggt gct      965
 Gly Val Asn Ser Gly Gln Thr Ala Pro Tyr Tyr Ala Ala Leu Gly Ala
     295                 300                 305

 gta gga gcc cat ctg act cac cag att tac act cta gac atc cac aga     1013
 Val Gly Ala His Leu Thr His Gln Ile Tyr Thr Leu Asp Ile His Arg
 310                 315                 320                 325

 cct gag gat tgt tgg aat aaa ttt atc tcc aac cga aca ctg gga cta     1061
 Pro Glu Asp Cys Trp Asn Lys Phe Ile Ser Asn Arg Thr Leu Gly Leu
                 330                 335                 340

 ata gtt ttt tta ggg att gtc ctt ggg aat ttg tgg aaa gaa aag aag     1109
 Ile Val Phe Leu Gly Ile Val Leu Gly Asn Leu Trp Lys Glu Lys Lys
             345                 350                 355

 aca gac aaa aca aag aag ggt ata gag aat aaa ata gaa aat taa tga     1157
 Thr Asp Lys Thr Lys Lys Gly Ile Glu Asn Lys Ile Glu Asn 
         360                 365                 370

 atgaaattta tctaggaatt tttaaaacat tttttacaaa atataattag atttgaatac   1217

 aaaatctgat acaatatgtt aaagaattaa gaacctgaag atgaagattt agagcatatt   1277

 tacctggatt ttacttattt gctagcaaaa ttcccccttg tcacagaaac cagggactct   1337

 tcaggatttg agatggcctt gagtatttta gttgatacat tcttctgccc attataattc   1397

 tcacctgaag ttatggggat tgcacgggtt ttggcacttt agaaaaagcc tgatgtgggt   1457

 cttacataaa tgaatgtctg tataagaaaa tggactcttt tttttaggga aaaataaaag   1517

 caactatggg aaaaaaaaaa                                               1537




      <210> 58
      <211> 1572
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (189)..(743)

      <400> 58
 gagttttttt tttgagaagc tgaagcaact ccaaggacac agttcacaga aatttggttc     60

 tcagccccaa aatactgatt gaattggaga caattacaag gactctctgg ccaaaaaccc    120

 ttgaagaggc cccgtgaagg aggcagtgag gagcttttga ttgctgacct gtgtcgtacc    180

 accccaga atg tgc act ggg ggc tgt gcc aga tgc ctg ggg ggg acc ctc     230
          Met Cys Thr Gly Gly Cys Ala Arg Cys Leu Gly Gly Thr Leu
            1               5                  10

 att ccc ctt gct ttt ttt ggc ttc ctg gct aac atc ctg tta ttt ttt      278
 Ile Pro Leu Ala Phe Phe Gly Phe Leu Ala Asn Ile Leu Leu Phe Phe
  15                  20                  25                  30

 cct gga gga ata tta gga agc ggt gtc ttg atg atc ttc cct gcg ctg      326
 Pro Gly Gly Ile Leu Gly Ser Gly Val Leu Met Ile Phe Pro Ala Leu
                  35                  40                  45

 gtg ttc ttg ggc ctg aag aac aat gac tgc tgt ggg tgc tgc ggc aac      374
 Val Phe Leu Gly Leu Lys Asn Asn Asp Cys Cys Gly Cys Cys Gly Asn
              50                  55                  60

 gag ggc tgt ggg aag cga ttt gcg atg ttc acc tcc acg ata ttt gct      422
 Glu Gly Cys Gly Lys Arg Phe Ala Met Phe Thr Ser Thr Ile Phe Ala
          65                  70                  75

 gtg gtt gga ttc ttg gga gct gga tac tcg ttt atc atc tca gcc att      470
 Val Val Gly Phe Leu Gly Ala Gly Tyr Ser Phe Ile Ile Ser Ala Ile
      80                  85                  90

 tca atc aac aag ggt cct aaa tgc ctc atg gcc aat agt aca tgg ggc      518
 Ser Ile Asn Lys Gly Pro Lys Cys Leu Met Ala Asn Ser Thr Trp Gly
  95                 100                 105                 110

 tac ccc ttc cac gac ggg gat tat ctc aat gat gag gcc tta tgg aac      566
 Tyr Pro Phe His Asp Gly Asp Tyr Leu Asn Asp Glu Ala Leu Trp Asn
                 115                 120                 125

 aag tgc cga gag cct ctc aat gtg gtt ccc tgg aat ctg acc ctc ttc      614
 Lys Cys Arg Glu Pro Leu Asn Val Val Pro Trp Asn Leu Thr Leu Phe
             130                 135                 140

 tcc atc ctg ctg gtc gta gga gga atc cag atg gtt ctc tgc gcc atc      662
 Ser Ile Leu Leu Val Val Gly Gly Ile Gln Met Val Leu Cys Ala Ile
         145                 150                 155

 cag gtg gtc aat ggc ctc ctg ggg acc ctc tgt ggg gac tgc cag tgt      710
 Gln Val Val Asn Gly Leu Leu Gly Thr Leu Cys Gly Asp Cys Gln Cys
     160                 165                 170

 tgt ggc tgc tgt ggg gga gat gga ccc gtt taa acctccga gatgagctgc      761
 Cys Gly Cys Cys Gly Gly Asp Gly Pro Val 
 175                 180

 tcagactcta cagcatgacg actacaattt cttttcataa aacttcttct cttcttggaa    821

 ttattaattc ctatctgctt cctagctgat aaagcttaga aaaggcagtt attccttctt    881

 tccaaccagc tttgctcgag ttagaatttt gttattttca aataaaaaat agtttggcca    941

 cttaacaaat ttgatttata aatctttcaa attagttcct ttttagaatt taccaacagg   1001

 ttcaaagcat acttttcatg atttttttat tacaaatgta aaatgtataa agtcacatgt   1061

 actgccatac tacttctttg tatataaaga tgtttatatc tttggaagtt ttacataaat   1121

 caaaggaaga aagcacattt aaaatgagaa actaagacca atttctgttt ttaagaggaa   1181

 aaagaatgat tgatgtatcc taagtattgt tatttgttgt ctttttttgc tgccttgctt   1241

 gagttgcttg tgactgatct tttgaggctg tcatcatggc tagggtttgg ctctcctaca   1301

 gtcttttgtt tgccatttcc cttgtctttg aaccaaaaca cagctctttc caagcttgga   1361

 gcgttgagag ggccctcttc tcccattggt gaaggcaaca ggttcaccac cgatccactc   1421

 ccagtggcca gcatgcactt ggtcgttcaa acctatccaa aaggactttc tcccaccaat   1481

 gtcccagagc caccgcatgt gctgcctgga gaatacagtt acaaggttgc ccaggtattg   1541

 ttccctgcaa gcttgggcag ccgcattcca g                                  1572




      <210> 59
      <211> 2329
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (322)..(2013)

      <400> 59
 tcaaaataaa attcctgaat ttgtacaagc cacaggaagc tagattgaga tcattatatg     60

 acaactggaa ggccaaggct atgggttacc tcaaattgag gaattttggc acctactcac    120

 aggctccatg agcagatgaa gtagacagct ttactcagta tctcagacca agaacttcat    180

 ctccatctcc aactagctga aacatcttcc ctcctcaacc tggaaaattc tctgacttag    240

 aaatttaaac aaaaccctcc cctttcattg aatctccatt gtctggagtt tgcttgtttt    300

 aatctagcct gttcctccac t  atg ggc tcc ctt tca aac tat gcc ctg ctt     351
                          Met Gly Ser Leu Ser Asn Tyr Ala Leu Leu
                            1               5                  10

 caa cta acc ctt act gct ttt ttg aca att cta gta caa cct cag cac      399
 Gln Leu Thr Leu Thr Ala Phe Leu Thr Ile Leu Val Gln Pro Gln His
                  15                  20                  25

 ctg ctt gct cca gtt ttc cgg aca cta tct atc ttg act aat cag tct      447
 Leu Leu Ala Pro Val Phe Arg Thr Leu Ser Ile Leu Thr Asn Gln Ser
              30                  35                  40

 aat tgc tgg tta tgt gaa cat cta gat aat gca gaa caa ccc gaa cta      495
 Asn Cys Trp Leu Cys Glu His Leu Asp Asn Ala Glu Gln Pro Glu Leu
          45                  50                  55

 gtt ttt gtt cct gcc agt gca agc acc tgg tgg acc tat tct gga caa      543
 Val Phe Val Pro Ala Ser Ala Ser Thr Trp Trp Thr Tyr Ser Gly Gln
      60                  65                  70

 tgg atg tat gaa agg gtg tgg tat cca caa gca gaa gta cag aat cac      591
 Trp Met Tyr Glu Arg Val Trp Tyr Pro Gln Ala Glu Val Gln Asn His
  75                  80                  85                  90

 tct act tcc tcc tat cgt aaa gtg act tgg cac tgg gaa gcc tcc atg      639
 Ser Thr Ser Ser Tyr Arg Lys Val Thr Trp His Trp Glu Ala Ser Met
                  95                 100                 105

 gaa gct caa ggt cta tcc ttt gct caa gta agg tta ttg gag gga aat      687
 Glu Ala Gln Gly Leu Ser Phe Ala Gln Val Arg Leu Leu Glu Gly Asn
             110                 115                 120

 ttt tct ctt tgc gta gaa aat aaa aat ggc agt gga ccc ttc cta ggt      735
 Phe Ser Leu Cys Val Glu Asn Lys Asn Gly Ser Gly Pro Phe Leu Gly
         125                 130                 135

 aat ata cct aaa caa tac tgt aat caa ata cta tgg ttt gat tct aca      783
 Asn Ile Pro Lys Gln Tyr Cys Asn Gln Ile Leu Trp Phe Asp Ser Thr
     140                 145                 150

 gat ggc acc ttc atg ccc tct ata gat gtt aca aat gaa tcc agg aac      831
 Asp Gly Thr Phe Met Pro Ser Ile Asp Val Thr Asn Glu Ser Arg Asn
 155                 160                 165                 170

 gat gat gat gat aca agt gtt tgc cta ggc act aga caa tgt tcc tgg      879
 Asp Asp Asp Asp Thr Ser Val Cys Leu Gly Thr Arg Gln Cys Ser Trp
                 175                 180                 185

 ttt gca ggt tgc aca aac cgg acc tgg aac agc tca gct gtt ccc ttg      927
 Phe Ala Gly Cys Thr Asn Arg Thr Trp Asn Ser Ser Ala Val Pro Leu
             190                 195                 200

 att ggt ctg ccc aat acc caa gac tac aaa tgg gta gat cga aat tct      975
 Ile Gly Leu Pro Asn Thr Gln Asp Tyr Lys Trp Val Asp Arg Asn Ser
         205                 210                 215

 gga ttg acc tgg tca ggt aat gac acc tgt ctc tat agc ttc caa aac     1023
 Gly Leu Thr Trp Ser Gly Asn Asp Thr Cys Leu Tyr Ser Phe Gln Asn
     220                 225                 230

 caa acc aaa ggc ctt ctg tac cag cta ttt cgc aac cta ttt tgc tct     1071
 Gln Thr Lys Gly Leu Leu Tyr Gln Leu Phe Arg Asn Leu Phe Cys Ser
 235                 240                 245                 250

 tat ggc ctg aca gag gca cat ggg aaa tgg aga tgt gca gat gcc agc     1119
 Tyr Gly Leu Thr Glu Ala His Gly Lys Trp Arg Cys Ala Asp Ala Ser
                 255                 260                 265

 ata act aat gac aaa ggt cat gat gga cac cgg acc ccc acc tgg tgg     1167
 Ile Thr Asn Asp Lys Gly His Asp Gly His Arg Thr Pro Thr Trp Trp
             270                 275                 280

 ctc aca ggt tcc aat ctg acc ttg tct gtg aac aac tct ggc ctc ttt     1215
 Leu Thr Gly Ser Asn Leu Thr Leu Ser Val Asn Asn Ser Gly Leu Phe
         285                 290                 295

 ttt ttg tgc ggc aat ggg gtg tac aaa ggg ttt cca cct aaa tgg tct     1263
 Phe Leu Cys Gly Asn Gly Val Tyr Lys Gly Phe Pro Pro Lys Trp Ser
     300                 305                 310

 ggg cga tgt gga ctt ggg tat ctt gta cct tcc ctc acc aga tac ctc     1311
 Gly Arg Cys Gly Leu Gly Tyr Leu Val Pro Ser Leu Thr Arg Tyr Leu
 315                 320                 325                 330

 acc tta aat gct agc caa att aca aac ctg aga tcc ttc att cat aaa     1359
 Thr Leu Asn Ala Ser Gln Ile Thr Asn Leu Arg Ser Phe Ile His Lys
                 335                 340                 345

 gta aca ccg cat aga tgc acc caa gga gac aca gac aat cca cct ctg     1407
 Val Thr Pro His Arg Cys Thr Gln Gly Asp Thr Asp Asn Pro Pro Leu
             350                 355                 360

 tat tgc aac ccc aag gac aat tca aca ata agg gcc ctt ttt cca agt     1455
 Tyr Cys Asn Pro Lys Asp Asn Ser Thr Ile Arg Ala Leu Phe Pro Ser
         365                 370                 375

 ttg gga act tat gat tta gaa aag gca att cta aac att tcc aaa gca     1503
 Leu Gly Thr Tyr Asp Leu Glu Lys Ala Ile Leu Asn Ile Ser Lys Ala
     380                 385                 390

 atg gaa cag gaa ttc agt gcc act aag cag acc ttg gaa gca cac caa     1551
 Met Glu Gln Glu Phe Ser Ala Thr Lys Gln Thr Leu Glu Ala His Gln
 395                 400                 405                 410

 tca aaa gtt agc agt tta gcc tct gca tcc cga aag gat cat gtc ttg     1599
 Ser Lys Val Ser Ser Leu Ala Ser Ala Ser Arg Lys Asp His Val Leu
                 415                 420                 425

 gat ata ccg acc acc caa cga caa acg gct tgt gga act gtt ggc aaa     1647
 Asp Ile Pro Thr Thr Gln Arg Gln Thr Ala Cys Gly Thr Val Gly Lys
             430                 435                 440

 cag tgt tgc ctc tat ata aat tat tcg gaa gaa ata aag tct aat ata     1695
 Gln Cys Cys Leu Tyr Ile Asn Tyr Ser Glu Glu Ile Lys Ser Asn Ile
         445                 450                 455

 cag cgt ctc cac gaa gca tcc gag aac ctg aag aat gta ccg tta ctt     1743
 Gln Arg Leu His Glu Ala Ser Glu Asn Leu Lys Asn Val Pro Leu Leu
     460                 465                 470

 gat tgg caa ggc ata ttt gca aaa gtg gga gac tgg ttc aga tca tgg     1791
 Asp Trp Gln Gly Ile Phe Ala Lys Val Gly Asp Trp Phe Arg Ser Trp
 475                 480                 485                 490

 ggc tat gtg ctt tta att gtt ctt ttc tgc tta ttc atc ttt gtt tta     1839
 Gly Tyr Val Leu Leu Ile Val Leu Phe Cys Leu Phe Ile Phe Val Leu
                 495                 500                 505

 atc tat gtt cgt gtc ttt cgc aaa tct cgc aga tcc ctt aac tcc caa     1887
 Ile Tyr Val Arg Val Phe Arg Lys Ser Arg Arg Ser Leu Asn Ser Gln
             510                 515                 520

 cct ctg aac cta gcc tta tct cca cag caa tca gca cag ctc ctt gtc     1935
 Pro Leu Asn Leu Ala Leu Ser Pro Gln Gln Ser Ala Gln Leu Leu Val
         525                 530                 535

 agt gaa act tca tgt caa gtt tca aat agg gca atg aag gga cta aca     1983
 Ser Glu Thr Ser Cys Gln Val Ser Asn Arg Ala Met Lys Gly Leu Thr
     540                 545                 550

 acc cat caa tat gac aca agt cta ctt tga g aatatctgaa caaacagcag     2034
 Thr His Gln Tyr Asp Thr Ser Leu Leu 
 555                 560

 ctgcagacaa aaagccttag ctaaactttg atgagtaaag caggtcttac cgagaattca   2094

 gctgccaaaa ccctcctctg agtgttcctc ttataagggc acttagcact aggacctccc   2154

 aaggtattgt aaataagcct tatcagaact ttttgtagtt tcattctgaa gccttaagac   2214

 acacaccata aagctgatct gtaaaccctt accccttgct gttcagagag ctactctttg   2274

 tagtgttctt gcatgcatat ataataaatg ttttttctat tgaaaaaaaa aaaaa        2329




      <210> 60
      <211> 2539
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (87)..(2402)

      <400> 60
 gcggaggcgg cagaggctgc ccgggcggcg gcgggggccg gcggcgcggg acgcgggccg     60

 ggtagcgccg ggccgagcgc ggagcc atg ggc cgg gct ggc acc ggg acc ggg     113
                              Met Gly Arg Ala Gly Thr Gly Thr Gly
                                1               5

 ggc gag gcg gtg gcc gcg gtg gtg gcg ggg ccg ctg ctg ctg ctg ctg      161
 Gly Glu Ala Val Ala Ala Val Val Ala Gly Pro Leu Leu Leu Leu Leu
  10                  15                  20                  25

 ctt gcc cgg ccc ccg cct gcc tcc gcc ggc tac agc ggg aag agc gag      209
 Leu Ala Arg Pro Pro Pro Ala Ser Ala Gly Tyr Ser Gly Lys Ser Glu
                  30                  35                  40

 gtg ggg ctg gtg tcc gag cac ttc tca cag gcc ccg cag agg ctg tcc      257
 Val Gly Leu Val Ser Glu His Phe Ser Gln Ala Pro Gln Arg Leu Ser
              45                  50                  55

 ttc tac agc tgg tat ggc agt gcc agg ctc ttc cgc ttc cgc gtg ccc      305
 Phe Tyr Ser Trp Tyr Gly Ser Ala Arg Leu Phe Arg Phe Arg Val Pro
          60                  65                  70

 cca gat gct gtg ctt cta cgc tgg ctc ctg cag gtc tcc cgg gag agc      353
 Pro Asp Ala Val Leu Leu Arg Trp Leu Leu Gln Val Ser Arg Glu Ser
      75                  80                  85

 ggc gct gcc tgc acc gac gcg gag atc acc gtg cac ttc cgt tcc ggc      401
 Gly Ala Ala Cys Thr Asp Ala Glu Ile Thr Val His Phe Arg Ser Gly
  90                  95                 100                 105

 gcc cct ccg gtc atc aac ccg ctg ggc acc agc ttc ccg gac gac acc      449
 Ala Pro Pro Val Ile Asn Pro Leu Gly Thr Ser Phe Pro Asp Asp Thr
                 110                 115                 120

 gcg gtg cag ccc tcc ttc cag gtc ggg gtg ccg ctg agc acc aca ccg      497
 Ala Val Gln Pro Ser Phe Gln Val Gly Val Pro Leu Ser Thr Thr Pro
             125                 130                 135

 aga agc aat gcc tcc gtc aac gtt tcc cac ccg gcc ccc ggg gac tgg      545
 Arg Ser Asn Ala Ser Val Asn Val Ser His Pro Ala Pro Gly Asp Trp
         140                 145                 150

 ttc gtg gcc gcc cac ctg ccc ccc tca tcc cag aag atc gag ttg aag      593
 Phe Val Ala Ala His Leu Pro Pro Ser Ser Gln Lys Ile Glu Leu Lys
     155                 160                 165

 ggc ttg gct ccc acc tgt gcc tac gtc ttc cag cct gaa ctg ctg gtc      641
 Gly Leu Ala Pro Thr Cys Ala Tyr Val Phe Gln Pro Glu Leu Leu Val
 170                 175                 180                 185

 acg cgg gtg gtc gag att tcc atc atg gag ccg gac gtg ccc ctt cct      689
 Thr Arg Val Val Glu Ile Ser Ile Met Glu Pro Asp Val Pro Leu Pro
                 190                 195                 200

 cag acc ctc ctc tcc cat ccc agc tac ctc aag gtc ttt gtc ccc gat      737
 Gln Thr Leu Leu Ser His Pro Ser Tyr Leu Lys Val Phe Val Pro Asp
             205                 210                 215

 tac acg cgg gag ctt ctg ctg gag ctg cgg gac tgc gtg tcc aat ggg      785
 Tyr Thr Arg Glu Leu Leu Leu Glu Leu Arg Asp Cys Val Ser Asn Gly
         220                 225                 230

 agc ctg ggc tgc ccc gtg cgt ctc acc gtg ggc ccg gtc acc ctg cct      833
 Ser Leu Gly Cys Pro Val Arg Leu Thr Val Gly Pro Val Thr Leu Pro
     235                 240                 245

 agc aac ttc cag aag gtg ctc acc tgc acc ggt gcc ccc tgg ccc tgc      881
 Ser Asn Phe Gln Lys Val Leu Thr Cys Thr Gly Ala Pro Trp Pro Cys
 250                 255                 260                 265

 cgc ctg ctg ctg ccc tca ccg ccc tgg gac cgg tgg ctg caa gtg aca      929
 Arg Leu Leu Leu Pro Ser Pro Pro Trp Asp Arg Trp Leu Gln Val Thr
                 270                 275                 280

 gct gag agc ctg gtg ggg ccc ctc ggg aca gtg gct ttc agt gct gta      977
 Ala Glu Ser Leu Val Gly Pro Leu Gly Thr Val Ala Phe Ser Ala Val
             285                 290                 295

 gct gcc ctc aca gct tgc agg cca cgg agc gtg acc gtc cag ccc ctt     1025
 Ala Ala Leu Thr Ala Cys Arg Pro Arg Ser Val Thr Val Gln Pro Leu
         300                 305                 310

 ctg cag agc agc caa aac cag agc ttc aat gcc tcc tct ggt ctg ctg     1073
 Leu Gln Ser Ser Gln Asn Gln Ser Phe Asn Ala Ser Ser Gly Leu Leu
     315                 320                 325

 tcc ccg agc ccc gac cac cag gac ctg ggc agg agt ggc agg gtg gac     1121
 Ser Pro Ser Pro Asp His Gln Asp Leu Gly Arg Ser Gly Arg Val Asp
 330                 335                 340                 345

 cgc agc ccc ttc tgc ctc aca aac tac cca gtc acg cgg gag gac atg     1169
 Arg Ser Pro Phe Cys Leu Thr Asn Tyr Pro Val Thr Arg Glu Asp Met
                 350                 355                 360

 gac gtg gtg tcg gtg cac ttc cag ccc ctg gac agg gtc tcg gtg agg     1217
 Asp Val Val Ser Val His Phe Gln Pro Leu Asp Arg Val Ser Val Arg
             365                 370                 375

 gtg tgt tcg gac acg ccc tcc gtg atg cgg ctg cgc ctg aac acc ggc     1265
 Val Cys Ser Asp Thr Pro Ser Val Met Arg Leu Arg Leu Asn Thr Gly
         380                 385                 390

 atg gac agc ggg ggt tcc ctc acc atc tcc ctg cgg gcc aac aag aca     1313
 Met Asp Ser Gly Gly Ser Leu Thr Ile Ser Leu Arg Ala Asn Lys Thr
     395                 400                 405

 gag atg cgg aac gag acc gtc gta gtg gcc tgc gtg aat gct gcc tcg     1361
 Glu Met Arg Asn Glu Thr Val Val Val Ala Cys Val Asn Ala Ala Ser
 410                 415                 420                 425

 ccc ttc ctt ggc ttc aat act tcg ctc aac tgc acc aca gcc ttc ttc     1409
 Pro Phe Leu Gly Phe Asn Thr Ser Leu Asn Cys Thr Thr Ala Phe Phe
                 430                 435                 440

 cag ggc tac cct ttg tct ctg agc gcc tgg tct cgc agg gcc aac ctc     1457
 Gln Gly Tyr Pro Leu Ser Leu Ser Ala Trp Ser Arg Arg Ala Asn Leu
             445                 450                 455

 atc atc ccc tac cca gag aca gac aac tgg tac ctc tcc ctg cag ctc     1505
 Ile Ile Pro Tyr Pro Glu Thr Asp Asn Trp Tyr Leu Ser Leu Gln Leu
         460                 465                 470

 atg tgc cct gag aat gct gag gac tgt gag cag gct gtg gtc cac gtg     1553
 Met Cys Pro Glu Asn Ala Glu Asp Cys Glu Gln Ala Val Val His Val
     475                 480                 485

 gag acc acc ttg tac ctg gtg ccc tgt ttg aac gat tgt gga ccc tat     1601
 Glu Thr Thr Leu Tyr Leu Val Pro Cys Leu Asn Asp Cys Gly Pro Tyr
 490                 495                 500                 505

 ggc cag tgc ctc ctg ctc cgc aga cac agc tac ctg tat gcc agc tgc     1649
 Gly Gln Cys Leu Leu Leu Arg Arg His Ser Tyr Leu Tyr Ala Ser Cys
                 510                 515                 520

 agc tgc aag gca ggc tgg cgt ggg tgg agc tgc acg gac aac agc aca     1697
 Ser Cys Lys Ala Gly Trp Arg Gly Trp Ser Cys Thr Asp Asn Ser Thr
             525                 530                 535

 gcc cag acg gtg gcc cag cag agg gcg gcc aca ctg ctg ctc acg ctc     1745
 Ala Gln Thr Val Ala Gln Gln Arg Ala Ala Thr Leu Leu Leu Thr Leu
         540                 545                 550

 agc aac ctc atg ttc ctg gcc ccc atc gcc gtc tca gtg cgg cga ttc     1793
 Ser Asn Leu Met Phe Leu Ala Pro Ile Ala Val Ser Val Arg Arg Phe
     555                 560                 565

 ttc ctg gtg gag gcc tcc gtc tac gcc tac acc atg ttc ttc tcc acg     1841
 Phe Leu Val Glu Ala Ser Val Tyr Ala Tyr Thr Met Phe Phe Ser Thr
 570                 575                 580                 585

 ttc tac cac gcc tgc gac cag ccc ggg gag gcg gtg ctg tgc atc ctc     1889
 Phe Tyr His Ala Cys Asp Gln Pro Gly Glu Ala Val Leu Cys Ile Leu
                 590                 595                 600

 agc tac gac acg ctg cag tac tgc gac ttc ttg ggc tcc ggg gcg gcc     1937
 Ser Tyr Asp Thr Leu Gln Tyr Cys Asp Phe Leu Gly Ser Gly Ala Ala
             605                 610                 615

 atc tgg gtc acc atc ctg tgc atg gca cgg ctc aag aca gtc ctg aaa     1985
 Ile Trp Val Thr Ile Leu Cys Met Ala Arg Leu Lys Thr Val Leu Lys
         620                 625                 630

 tac gtg ctg ttt ctt ctg ggt aca ctg gtc atc gcc atg tcc ttg cag     2033
 Tyr Val Leu Phe Leu Leu Gly Thr Leu Val Ile Ala Met Ser Leu Gln
     635                 640                 645

 ctg gac cgc agg ggc atg tgg aac atg ctg ggg ccc tgc ctc ttt gcc     2081
 Leu Asp Arg Arg Gly Met Trp Asn Met Leu Gly Pro Cys Leu Phe Ala
 650                 655                 660                 665

 ttc gtg atc atg gcc tcc atg tgg gct tac cgc tgc ggg cac cgg cgc     2129
 Phe Val Ile Met Ala Ser Met Trp Ala Tyr Arg Cys Gly His Arg Arg
                 670                 675                 680

 cag tgc tac ccc acc tcg tgg cag cgc tgg gcc ttc tac ctc ctg ccc     2177
 Gln Cys Tyr Pro Thr Ser Trp Gln Arg Trp Ala Phe Tyr Leu Leu Pro
             685                 690                 695

 ggc gtc tct atg gcc tct gtg ggc atc gcc atc tac acc tcc atg atg     2225
 Gly Val Ser Met Ala Ser Val Gly Ile Ala Ile Tyr Thr Ser Met Met
         700                 705                 710

 act agc gac aac tac tac tac acc cac agc atc tgg cac atc ctg ctg     2273
 Thr Ser Asp Asn Tyr Tyr Tyr Thr His Ser Ile Trp His Ile Leu Leu
     715                 720                 725

 gcc ggg agc gca gcc ttg ctg ctg ccg cca cct gac cag ccc gcc gag     2321
 Ala Gly Ser Ala Ala Leu Leu Leu Pro Pro Pro Asp Gln Pro Ala Glu
 730                 735                 740                 745

 ccc tgg gcc tgc tcg cag aaa ttc ccc tgc cac tat cag atc tgc aag     2369
 Pro Trp Ala Cys Ser Gln Lys Phe Pro Cys His Tyr Gln Ile Cys Lys
                 750                 755                 760

 aac gat cgg gag gaa ctg tac gca gtg acg tga cactggcc tggggacagc     2420
 Asn Asp Arg Glu Glu Leu Tyr Ala Val Thr 
             765                 770

 tgctgctctg atgacctctt cagccaggag ctgtatcgag ggggaggcgc ctggtccagc   2480

 cctggacaga ttgatttcca gctgaataaa ttggcctaga taccctcaaa aaaaaaaaa    2539




      <210> 61
      <211> 1188
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1188)

      <400> 61
  atg tgg ctg ccg cgc gtc tcc agc aca gca gtg acc gcg ctc ctc ctg      48
  Met Trp Leu Pro Arg Val Ser Ser Thr Ala Val Thr Ala Leu Leu Leu
    1               5                  10                  15

 gcg cag acc ttc ctc ctc ctc ttt ctg gtt tcc cgg cca ggg ccc tcg       96
 Ala Gln Thr Phe Leu Leu Leu Phe Leu Val Ser Arg Pro Gly Pro Ser
              20                  25                  30

 tcc cca gca ggc ggc gag gcg cgc gtg cat gtg ctg gtg ctg tcc tcg      144
 Ser Pro Ala Gly Gly Glu Ala Arg Val His Val Leu Val Leu Ser Ser
          35                  40                  45

 tgg cgc tcg ggc tcg tcc ttc gtg ggc caa ctc ttc aac cag cac ccc      192
 Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Asn Gln His Pro
      50                  55                  60

 gac gtc ttc tac cta atg gag ccc gcg tgg cac gtg tgg acc acc ctg      240
 Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Thr Thr Leu
  65                  70                  75                  80

 tcg cag ggc agc gcc gca acg ctg cac atg gct gtg cgc gac ctg gtg      288
 Ser Gln Gly Ser Ala Ala Thr Leu His Met Ala Val Arg Asp Leu Val
                  85                  90                  95

 cgc tcc gtc ttc ctg tgc gac atg gac gtg ttt gat gcc tat ctg cct      336
 Arg Ser Val Phe Leu Cys Asp Met Asp Val Phe Asp Ala Tyr Leu Pro
             100                 105                 110

 tgg cgc cgc aac ctg tcc gac ctc ttc cag tgg gcc gtg agc cgt gca      384
 Trp Arg Arg Asn Leu Ser Asp Leu Phe Gln Trp Ala Val Ser Arg Ala
         115                 120                 125

 ctg tgc tcg cca ccc gcc tgc agt gcc ttt ccc cga ggc gcc atc agc      432
 Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe Pro Arg Gly Ala Ile Ser
     130                 135                 140

 agc gag gcc gtg tgc aag cca ctg tgc gcg cgg cag tcc ttc acc ctg      480
 Ser Glu Ala Val Cys Lys Pro Leu Cys Ala Arg Gln Ser Phe Thr Leu
 145                 150                 155                 160

 gcc cgg gag gcc tgc cgc tcc tac agc cac gtg gtg ctc aag gag gtg      528
 Ala Arg Glu Ala Cys Arg Ser Tyr Ser His Val Val Leu Lys Glu Val
                 165                 170                 175

 cgc ttc ttc aac ctg cag gtg ctc tac ccg ctg ctc agc gac ccc gcg      576
 Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro Leu Leu Ser Asp Pro Ala
             180                 185                 190

 ctc aac cta cgc atc gtg cac ctg gtg cgc gac ccg cgg gcc gtg ctg      624
 Leu Asn Leu Arg Ile Val His Leu Val Arg Asp Pro Arg Ala Val Leu
         195                 200                 205

 cgc tcc cgg gag cag aca gcc aag gct ctg gcg cgt gac aac ggc atc      672
 Arg Ser Arg Glu Gln Thr Ala Lys Ala Leu Ala Arg Asp Asn Gly Ile
     210                 215                 220

 gtg ctg ggc acc aac ggc acg tgg gtg gag gcc gac ccc ggc ctg cgc      720
 Val Leu Gly Thr Asn Gly Thr Trp Val Glu Ala Asp Pro Gly Leu Arg
 225                 230                 235                 240

 gtg gtg cgc gag gtg tgc cgt agc cac gta cgc atc gcc gag gcc gcc      768
 Val Val Arg Glu Val Cys Arg Ser His Val Arg Ile Ala Glu Ala Ala
                 245                 250                 255

 aca ctc aag ccg cca ccc ttt ctg cgc ggc cgc tac cgc ctg gtg cgc      816
 Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly Arg Tyr Arg Leu Val Arg
             260                 265                 270

 ttc gag gac ctg gcg cgg gag ccg ctg gca gaa atc cgt gcg ctc tac      864
 Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala Glu Ile Arg Ala Leu Tyr
         275                 280                 285

 gcc ttc act ggg ctc agt ctc acg cca cag ctc gag gcc tgg atc cat      912
 Ala Phe Thr Gly Leu Ser Leu Thr Pro Gln Leu Glu Ala Trp Ile His
     290                 295                 300

 aac atc acc cac gga tct gga cct ggt gcg cgc cgc gaa gcc ttc aag      960
 Asn Ile Thr His Gly Ser Gly Pro Gly Ala Arg Arg Glu Ala Phe Lys
 305                 310                 315                 320

 act tcg tcc agg aat gcg ctc aac gtc tcc cag gcc tgg cgc cat gcg     1008
 Thr Ser Ser Arg Asn Ala Leu Asn Val Ser Gln Ala Trp Arg His Ala
                 325                 330                 335

 ctg ccc ttt gcc aag atc cgc cgc gtg cag gaa ctg tgc gct ggt gcg     1056
 Leu Pro Phe Ala Lys Ile Arg Arg Val Gln Glu Leu Cys Ala Gly Ala
             340                 345                 350

 ctg cag ctg ctg ggc tac cgg cct gtg tac tct gag gac gag cag cgc     1104
 Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr Ser Glu Asp Glu Gln Arg
         355                 360                 365

 aac ctc gcc ctt gat ctg gtg ctg cca cga ggc ctg aac ggc ttc act     1152
 Asn Leu Ala Leu Asp Leu Val Leu Pro Arg Gly Leu Asn Gly Phe Thr
     370                 375                 380

 tgg gca tca tcc acc gcc tcg cac ccc cga aat tag                     1188
 Trp Ala Ser Ser Thr Ala Ser His Pro Arg Asn 
 385                 390                 395





      <210> 62
      <211> 2027
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (502)..(1440)

      <400> 62
 cgcgctgctg cgagaccagc cgcggcgtct ttggcagtag tgggcgtcct tgcgggtcca     60

 ggagggcccc tctcccgcga ccgccgacca cgatgagagc gtgaagaccc tctcgaaagg    120

 aagggctctg ctctacacac tggtgtctcc tgcggaaggg cagctgggca cgccttccag    180

 accgaggtta cttgccacag aagtgtttct gggctgcagc cctcaacctt ggcccaaata    240

 aactttctgt attaattttg ccttagtgtc gttctttaag tcaacaagga tggccaaggc    300

 agtcactaat ctcacactca cctgatagcc acaggaacaa cattttccca gctataagca    360

 aaagttgaaa aatcagtaac ccaagatgac taaccaaatc aatatgctgg gcaggatgag    420

 acatcagtgt ctgcctcaga cagaagagca cacacaaaac atgacctctc accccaagcc    480

 cagttacagc agaaagtttt c  atg gag aaa tgg aat cac act tca aat gat     531
                          Met Glu Lys Trp Asn His Thr Ser Asn Asp
                            1               5                  10

 ttc att ttg ttg ggt ctg ctt ccc cca aat caa act gga ata ttt ctc      579
 Phe Ile Leu Leu Gly Leu Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu
                  15                  20                  25

 ttg tgc ctt atc atc ctc ata ttc ttt ctg gcc tcg gtg ggt aac tcg      627
 Leu Cys Leu Ile Ile Leu Ile Phe Phe Leu Ala Ser Val Gly Asn Ser
              30                  35                  40

 gcc atg att cac ctc atc cac gtg gat cct cgt ctc cac aca ccg atg      675
 Ala Met Ile His Leu Ile His Val Asp Pro Arg Leu His Thr Pro Met
          45                  50                  55

 tac ttt ctt ctc agc cag ctc tcc ctt atg gac ctg atg tac atc tcc      723
 Tyr Phe Leu Leu Ser Gln Leu Ser Leu Met Asp Leu Met Tyr Ile Ser
      60                  65                  70

 acc acc gtc ccc aag atg gcg tac aac ttc ctg tcc ggc cag aaa ggc      771
 Thr Thr Val Pro Lys Met Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly
  75                  80                  85                  90

 atc tcc ttc ctg gga tgt ggt gtg caa agc ttc ttc ttc ctg acc atg      819
 Ile Ser Phe Leu Gly Cys Gly Val Gln Ser Phe Phe Phe Leu Thr Met
                  95                 100                 105

 gcg tgt tct gaa ggc tta ctc ctg acc tcc atg gcc tac gac cgt tat      867
 Ala Cys Ser Glu Gly Leu Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr
             110                 115                 120

 ttg gcc atc tgc cac tct ctc tat tat cct atc cgc atg agt aaa atg      915
 Leu Ala Ile Cys His Ser Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met
         125                 130                 135

 atg tgt gtg aag atg att gga ggc tct tgg aca ctg ggg tcc atc aac      963
 Met Cys Val Lys Met Ile Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn
     140                 145                 150

 tcc ttg gca cac aca gtc ttt gcc ctt cat att ccc tac tgc agg tct     1011
 Ser Leu Ala His Thr Val Phe Ala Leu His Ile Pro Tyr Cys Arg Ser
 155                 160                 165                 170

 agg gct att gac cat ttc ttc tgc gat gtc cca gcc atg ttg ctt ctt     1059
 Arg Ala Ile Asp His Phe Phe Cys Asp Val Pro Ala Met Leu Leu Leu
                 175                 180                 185

 gcc tgt aca gat act tgg gtc tat gaa tat atg gtt ttt gta agt aca     1107
 Ala Cys Thr Asp Thr Trp Val Tyr Glu Tyr Met Val Phe Val Ser Thr
             190                 195                 200

 agc ctc ttt ctc ctt ttc cct ttc att ggc atc act tct tcc tgt ggc     1155
 Ser Leu Phe Leu Leu Phe Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly
         205                 210                 215

 cga gtc cta ttt gct gtc tat cat atg cac tca aag gag ggg aga aaa     1203
 Arg Val Leu Phe Ala Val Tyr His Met His Ser Lys Glu Gly Arg Lys
     220                 225                 230

 aag gcc ttc acc acc att tca aca cat tta act gta gtg atc tct tac     1251
 Lys Ala Phe Thr Thr Ile Ser Thr His Leu Thr Val Val Ile Ser Tyr
 235                 240                 245                 250

 tat gca cct ttt gtc tac acc tat ctt cgg ccc agg aat ctc cgc tca     1299
 Tyr Ala Pro Phe Val Tyr Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser
                 255                 260                 265

 cca gct gaa gac aag atc ctg gca gtc ttc tac acc atc ctt acc ccc     1347
 Pro Ala Glu Asp Lys Ile Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro
             270                 275                 280

 atg ctc aat ccc att atc tac agc ctg agg aat aag gaa gtc ctg ggg     1395
 Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly
         285                 290                 295

 gct atg agg aga gtg ttt ggg ata ttc tct ttc ctg aaa gaa taa tca     1443
 Ala Met Arg Arg Val Phe Gly Ile Phe Ser Phe Leu Lys Glu 
     300                 305                 310

 tggccatccc cactcccttt gtatttcctc tttccaagtt gattccaaca cgctagagca   1503

 gggttgtcca atagaaatac aacataattt aaaattttct aataggtaca tttaagcagt   1563

 caaataaatt taaataatat atttaattca aaacaatgtt ataattaata ttaatattaa   1623

 caatattgat gttaattaca tagcatacta tttcaataaa ttatatgcaa tatattatag   1683

 tacatgtttg tacatatatt actattaacg tgataatgtt tattcttgta tattgacata   1743

 gaatttcttc atgtaataac acaaatttgt taatgttgcc ttttactctg tttgcattct   1803

 aagtcttcaa agtcttgtgt ttgttttata gagtgcagcg cagcttggac aaaacacatt   1863

 tcaagtgccc agtagtcagt gtctatagtg ttggacagca cattcttaga gcatccccaa   1923

 tcaatagttt cagaagttat atatgcatgt gtatgtgcat gtatggtgta tacaaacata   1983

 tttttgttat atacaatatt gctgatgaac tgaaaattaa caag                    2027




      <210> 63
      <211> 2107
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1146)..(2045)

      <400> 63
 tcatttgcag gttgtgggtt ccaggtattt ctgtccctca ccctcctggg tggtgagtgc     60

 cttctcctgg ctgcaatgtc ctgtgatcgc tatgtggcta tctgtcaccc gctgcgctat    120

 ccgattctta tgaaggagta tgccagcgct ctcatggctg gaggctcctg gctcattggg    180

 gttttcaact ccacagtcca cacagcttat gcactgcagt ttcccttctg tggctctagg    240

 gcaattgatc acttcttctg tgaagtccct gccatgttga agttgtcctg tgcagacaca    300

 acacgctggt ggtaggggct ggagaatggg gattgggcag cccagttccg ctctcctcat    360

 gcagtgtcct gcgtctgtca tctgcttggg ttgtggcttg tgtggaagga ccacgactga    420

 ggttgccagg ccagcaaaga cggggtgcag aagagtctca gccagagtga tgtgctgggc    480

 agcgtccaat tttaccaccc tccgcatcag gtcaaacagc tgcacgtgct ccagagagtc    540

 ttggagcatg tcactcttca gacgtttgca gttcttcaca tatgggctgt cagagctgtt    600

 ctcatcccaa actaggcccc atttgtagaa atatttctgc ttcttggtac aggagatcac    660

 gcgtaatggg atgagccgta gggtcttcaa catcaccagg cgctcttggt tttcacaggt    720

 catggcgatg tggtgcccac ggtcagaggt ggcattgggg aagtcagcca ctcggacgct    780

 ggtgctcctc actgacttct catcgctcct gtgctcgctg tagacggtgt ttaactcaga    840

 atccacatgc aggatgttct cggttttcag gtgtgcgtgg gtcagccggt tctcgtgcag    900

 aaatccgagc cccgggctca ctcgctgggg ctgccggagg acgcgctgct gcgagaccag    960

 ccgcggcgtc tttggcagta gtgggcgtgc ttgcgggtcc aggagggccc ctctcccgcg   1020

 accgccgacc acgatgagag cgtgaagacc ctctcgaaag gaagggctct gctctacaca   1080

 ctggtgtctc ctgcggaagg gcagctgggc acgccttcca gaccgaggta cagcagaaag   1140

 ttttc    atg gag aaa tgg aat cac act tca aat gat ttc att ttg ttg    1187
          Met Glu Lys Trp Asn His Thr Ser Asn Asp Phe Ile Leu Leu
            1               5                  10

 ggt ctg ctt ccc cca aat caa act gga ata ttt ctc ttg tgc ctt atc     1235
 Gly Leu Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu Leu Cys Leu Ile
  15                  20                  25                  30

 atc ctc ata ttc ttt ctg gcc tcg gtg ggt aac tcg gcc atg att cac     1283
 Ile Leu Ile Phe Phe Leu Ala Ser Val Gly Asn Ser Ala Met Ile His
                  35                  40                  45

 ctc atc cac gtg gat cct cgt ctc cac aca ccg atg tac ttt ctt ctc     1331
 Leu Ile His Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu
              50                  55                  60

 agc cag ctc tcc ctt atg gac ctg atg tac atc tcc acc acc gtc ccc     1379
 Ser Gln Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro
          65                  70                  75

 aag atg gcg tac aac ttc ctg tcc ggc cag aaa ggc atc tcc ttc ctg     1427
 Lys Met Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu
      80                  85                  90

 gga tgt ggt gtg caa agc ttc ttc ttc ctg acc atg gcg tgt tct gaa     1475
 Gly Cys Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu
  95                 100                 105                 110

 ggc tta ctc ctg acc tcc atg gcc tac gac cgt tat ttg gcc atc tgc     1523
 Gly Leu Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys
                 115                 120                 125

 cac tct ctc tat tat cct atc cgc atg agt aaa atg atg tgt gtg aag     1571
 His Ser Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met Met Cys Val Lys
             130                 135                 140

 atg att gga ggc tct tgg aca ctg ggg tcc atc aac tcc ttg gca cac     1619
 Met Ile Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn Ser Leu Ala His
         145                 150                 155

 aca gtc ttt gcc ctt cat att ccc tac tgc agg tct agg gct att gac     1667
 Thr Val Phe Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asp
     160                 165                 170

 cat ttc ttc tgc gat gtc cca gcc atg ttg ctt ctt gcc tgt aca gat     1715
 His Phe Phe Cys Asp Val Pro Ala Met Leu Leu Leu Ala Cys Thr Asp
 175                 180                 185                 190

 act tgg gtc tat gaa tat atg gtt ttt gta agt aca agc ctc ttt ctc     1763
 Thr Trp Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu
                 195                 200                 205

 ctt ttc cct ttc att ggc atc act tct tcc tgt ggc cga gtc cta ttt     1811
 Leu Phe Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly Arg Val Leu Phe
             210                 215                 220

 gct gtc tat cat atg cac tca aag gag ggg aga aaa aag gcc ttc acc     1859
 Ala Val Tyr His Met His Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr
         225                 230                 235

 acc att tca aca cat tta act gta gtg atc tct tac tat gca cct ttt     1907
 Thr Ile Ser Thr His Leu Thr Val Val Ile Ser Tyr Tyr Ala Pro Phe
     240                 245                 250

 gtc tac acc tat ctt cgg ccc agg aat ctc cgc tca cca gct gaa gac     1955
 Val Tyr Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp
 255                 260                 265                 270

 aag atc ctg gca gtc ttc tac acc atc ctt acc ccc atg ctc aat ccc     2003
 Lys Ile Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro
                 275                 280                 285

 att atc tac agc ctg agg aat aag gaa gtc ctg ggg cta tga ggagagt     2052
 Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Leu 
             290                 295

 gtttgggata ttctctttcc tgaaagaata atcatggcca tccccactcc acaag        2107




      <210> 64
      <211> 2547
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2547)

      <400> 64
  atg tgg ctg cgg ctt ggc ccg ccc tcg ctg tcc ctg agc ccc aag ccc      48
  Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro
    1               5                  10                  15

 acg gtt ggc agg agc ctg tgc ctc acc ctg tgg ttc ctc agt ttg gcg       96
 Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala
              20                  25                  30

 ctg agg gcc agt acc cag gcc cca gca ccc aca gtc aac act cac ttt      144
 Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe
          35                  40                  45

 ggg aag cta agg ggt gcc cga gta cca ctg ccc agt gag atc ctg ggg      192
 Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly
      50                  55                  60

 cct gtg gac caa tac ctg ggg gtg ccc tac gca gct ccc ccg atc ggc      240
 Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly
  65                  70                  75                  80

 gag aaa cgt ttc ctg ccc cct gaa cca ccc cca tcc tgg tcg ggc atc      288
 Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile
                  85                  90                  95

 cgg aac gcc aca cac ttt ccc cca gtg tgc ccc cag aac atc cac aca      336
 Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr
             100                 105                 110

 gct gtg ccc gaa gtc atg ctg ccg gtc tgg ttc act gcc aac ttg gat      384
 Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp
         115                 120                 125

 atc gtc gct act tac atc cag gag ccc aac gaa gac tgt ctc tac ctg      432
 Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu
     130                 135                 140

 aac gtc tat gtg ccg acg gag gat gta aag cgg att tcc aag gaa tgc      480
 Asn Val Tyr Val Pro Thr Glu Asp Val Lys Arg Ile Ser Lys Glu Cys
 145                 150                 155                 160

 gcc cga aag ccc aac aag aaa att tgt agg aaa gga gga tcc ggc gct      528
 Ala Arg Lys Pro Asn Lys Lys Ile Cys Arg Lys Gly Gly Ser Gly Ala
                 165                 170                 175

 aag aaa cag ggc gag gac tta gcg gat aat gac ggg gat gaa gat gaa      576
 Lys Lys Gln Gly Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu
             180                 185                 190

 gac atc cgg gac agt ggt gct aaa ccc gtc atg gtc tac atc cac gga      624
 Asp Ile Arg Asp Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly
         195                 200                 205

 ggc tct tac atg gaa ggg aca ggc aac atg att gat ggc agc atc ctc      672
 Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu
     210                 215                 220

 gcc agt tat ggc aat gtc atc gtc atc acc ctc aac tat cgg gtt gga      720
 Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly
 225                 230                 235                 240

 gtg cta ggt ttc ctg agt act gga gat cag gct gcc aag ggc aac tat      768
 Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr
                 245                 250                 255

 ggg ctc ctt gac cag atc cag gcc ctc cgc tgg gtg agc gag aat att      816
 Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile
             260                 265                 270

 gcc ttc ttc ggg gga gac ccc cgc cgg atc act gtc ttt ggc tcg ggc      864
 Ala Phe Phe Gly Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly
         275                 280                 285

 att ggt gca tcc tgc gtc agc ctc ctc acg ttg tca cat cac tca gag      912
 Ile Gly Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu
     290                 295                 300

 gga ctt ttc cag aga gcc atc atc caa agt ggc tct gct ctg tcc agc      960
 Gly Leu Phe Gln Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser
 305                 310                 315                 320

 tgg gct gtg aac tac caa cca gtg aag tac acc agc ctg ctg gca gac     1008
 Trp Ala Val Asn Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp
                 325                 330                 335

 aaa gtg ggc tgt aat gtg ctg gac acc gtg gat atg gtg gac tgt ctt     1056
 Lys Val Gly Cys Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu
             340                 345                 350

 cgg caa aag agt gcc aag gag ctg gta gag cag gac atc cag cca gcc     1104
 Arg Gln Lys Ser Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala
         355                 360                 365

 cgc tac cac gtg gcc ttt ggc cct gtg att gat ggt gat gtc att cct     1152
 Arg Tyr His Val Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro
     370                 375                 380

 gat gac cct gag atc ctc atg gag cag ggc gag ttc ctc aac tat gac     1200
 Asp Asp Pro Glu Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp
 385                 390                 395                 400

 atc atg cta ggt gtc aac cag ggc gag ggt ctc aag ttt gtg gaa ggg     1248
 Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly
                 405                 410                 415

 gtg gtg gac cct gag gat ggt gtc tct ggc act gac ttt gac tat tcc     1296
 Val Val Asp Pro Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser
             420                 425                 430

 gtc tcc aat ttt gtg gac aat ctg tat ggc tat cct gag ggt aag gac     1344
 Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp
         435                 440                 445

 acc ctg cga gag acc atc aag ttc atg tat aca gac tgg gca gac cgt     1392
 Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg
     450                 455                 460

 gac aac cct gag acc cgc cgt aaa aca ctg gtg gca ctc ttc act gac     1440
 Asp Asn Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp
 465                 470                 475                 480

 cac cag tgg gtg gag ccc tca gtg gtg aca gcc gat ctg cat gcc cgc     1488
 His Gln Trp Val Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg
                 485                 490                 495

 tac ggc tcg cct acc tac ttc tac gcc ttc tat cat cac tgc cag agc     1536
 Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser
             500                 505                 510

 ctc atg aag cct gct tgg tca gat gca gct cat ggg gat gaa gta ccc     1584
 Leu Met Lys Pro Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro
         515                 520                 525

 tat gtt ttt ggg gtt cct atg gta ggc ccc act gac ctt ttc ccc tgc     1632
 Tyr Val Phe Gly Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys
     530                 535                 540

 aac ttc tcc aag aat gat gtt atg ctc agt gct gtc gtc atg acc tat     1680
 Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr
 545                 550                 555                 560

 tgg acc aac ttt gcc aag act ggg gat ccc aac aag ccg gtc ccc cag     1728
 Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln
                 565                 570                 575

 gac acc aag ttc att cac acc aag gcc aac cgc ttt gag gaa gtg gcc     1776
 Asp Thr Lys Phe Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala
             580                 585                 590

 tgg tcc aaa tac aat ccc cga gac cag ctc tac ctt cac atc ggg ctg     1824
 Trp Ser Lys Tyr Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu
         595                 600                 605

 aaa cca agg gtc cga gat cat tac cgg gcc act aag gtg gcc ttt tgg     1872
 Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp
     610                 615                 620

 aaa cat ctg gtg ccc cac cta tac aac ctg cat gac atg ttc cac tat     1920
 Lys His Leu Val Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr
 625                 630                 635                 640

 acg tcc acc acc acc aaa gtg ccg cct ccg gat acc acc cac agc tcc     1968
 Thr Ser Thr Thr Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser
                 645                 650                 655

 cac atc acc cgc agg ccc aat ggc aag acc tgg agc acc aag cgg cca     2016
 His Ile Thr Arg Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro
             660                 665                 670

 gcc atc tca cct gcc tac agc aac gag aat gcc cag ggg tcc tgg aac     2064
 Ala Ile Ser Pro Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn
         675                 680                 685

 ggg gac cag gat gca ggg cca ctc ctg gtg gag aac cct cgt gac tac     2112
 Gly Asp Gln Asp Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr
     690                 695                 700

 tcc act gaa tta agt gtc acc atc gcc gtg ggg gcc tcc ctc ctg ttc     2160
 Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe
 705                 710                 715                 720

 ctt aac gtt ctg gcc ttc gct gcc ctc tac tac cgt aag gac aaa cgg     2208
 Leu Asn Val Leu Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg
                 725                 730                 735

 cgc cag gag ccc ctg cgg cag cct agc cct cag cgg gga gcc ggg gcc     2256
 Arg Gln Glu Pro Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala
             740                 745                 750

 ccg gag ttg gga gct gct cca gag gag gag ctg gca gca tta caa ctg     2304
 Pro Glu Leu Gly Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu
         755                 760                 765

 ggc ccc acc cac cac gag tgt gag gcc ggt ccc ccc cat gac acg ctg     2352
 Gly Pro Thr His His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu
     770                 775                 780

 cgc ctc act gca ttg ccc gac tac acc ctg acc ctg cgg cgc tcc ccg     2400
 Arg Leu Thr Ala Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro
 785                 790                 795                 800

 gat gac atc cca ctc atg acc ccc aac acc atc act atg atc ccc aac     2448
 Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn
                 805                 810                 815

 tcc ctg gta ggg ctg cag aca ttg cac ccc tat aac acc ttt gcc gca     2496
 Ser Leu Val Gly Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala
             820                 825                 830

 ggg ttc aac agt acc ggg ctg ccc cac tca cac tcc act acc cgg gta     2544
 Gly Phe Asn Ser Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val
         835                 840                 845

 tag                                                                 2547
 






      <210> 65
      <211> 3059
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2811)

      <400> 65
  atg gtc tgt tcg gct gcc cca ctg ctg ctc ctg gcc aca act ctt ccc      48
  Met Val Cys Ser Ala Ala Pro Leu Leu Leu Leu Ala Thr Thr Leu Pro
    1               5                  10                  15

 ctg ctg ggg tca cca gtt gcc caa gca tcc caa cct gta agt gag act       96
 Leu Leu Gly Ser Pro Val Ala Gln Ala Ser Gln Pro Val Ser Glu Thr
              20                  25                  30

 ggg gtg aga ccc agg gaa ggt ctg cag agg cga caa tgg gga ccc ctg      144
 Gly Val Arg Pro Arg Glu Gly Leu Gln Arg Arg Gln Trp Gly Pro Leu
          35                  40                  45

 att ggg aga gac aaa gca tgg aat gaa agg ata gac aga ccc ttc cct      192
 Ile Gly Arg Asp Lys Ala Trp Asn Glu Arg Ile Asp Arg Pro Phe Pro
      50                  55                  60

 gcc tgc ccc atc ccc cta tct tct agc ttt ggc cga tgg ccc aag ggc      240
 Ala Cys Pro Ile Pro Leu Ser Ser Ser Phe Gly Arg Trp Pro Lys Gly
  65                  70                  75                  80

 cag aca atg tgg gcc cag acc tcc acc ctc acc ctg aca gag gag gag      288
 Gln Thr Met Trp Ala Gln Thr Ser Thr Leu Thr Leu Thr Glu Glu Glu
                  85                  90                  95

 ttg gga cag agt cag gct gga ggg gaa tct gga tct ggg cag ctc ctg      336
 Leu Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly Ser Gly Gln Leu Leu
             100                 105                 110

 gac caa gag aat gga gca ggg gag tgt aat gtc aac cac aag ggg aat      384
 Asp Gln Glu Asn Gly Ala Gly Glu Cys Asn Val Asn His Lys Gly Asn
         115                 120                 125

 ttc tat tgt gct tgc ctc tct ggc tac cag tgg aac acc agc atc tgc      432
 Phe Tyr Cys Ala Cys Leu Ser Gly Tyr Gln Trp Asn Thr Ser Ile Cys
     130                 135                 140

 ctc cat tac cct cct tgt caa agc ctc cac aac cac cag cct tgt ggc      480
 Leu His Tyr Pro Pro Cys Gln Ser Leu His Asn His Gln Pro Cys Gly
 145                 150                 155                 160

 tgc ctt gtc ttc agc cat ccc gaa ccc ggg tac tgc cag ttg ctg cca      528
 Cys Leu Val Phe Ser His Pro Glu Pro Gly Tyr Cys Gln Leu Leu Pro
                 165                 170                 175

 cct ggt gag tac atg agc tgc ttc gag gcc cag ggc ttc aag tgg aac      576
 Pro Gly Glu Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn
             180                 185                 190

 ctg tat gag gtg gtg agg gtg ccc ttg aag gcg aca gat gtg gct cga      624
 Leu Tyr Glu Val Val Arg Val Pro Leu Lys Ala Thr Asp Val Ala Arg
         195                 200                 205

 ctt cca tac cag ctg tcc atc tcc tgt gcc acc tcc cct ggc ttc cag      672
 Leu Pro Tyr Gln Leu Ser Ile Ser Cys Ala Thr Ser Pro Gly Phe Gln
     210                 215                 220

 ctg agc tgc tgc atc ccc agc aca aac ctg gcc tac acc gcg gcc tgg      720
 Leu Ser Cys Cys Ile Pro Ser Thr Asn Leu Ala Tyr Thr Ala Ala Trp
 225                 230                 235                 240

 agc cct gga gag ggc agc aaa gct tcc tcc ttc aac gag tca ggc tct      768
 Ser Pro Gly Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser
                 245                 250                 255

 cag tgc ttt gtg ctg gct gtt cag cgc tgc ccg atg gct gac acc acg      816
 Gln Cys Phe Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp Thr Thr
             260                 265                 270

 tac gct tgt gac ctg cag agc ctg ggc ctg gct cca ctc agg gtc ccc      864
 Tyr Ala Cys Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro
         275                 280                 285

 atc tcc atc acc atc atc cag gat gga gac atc acc tgc cct gag gac      912
 Ile Ser Ile Thr Ile Ile Gln Asp Gly Asp Ile Thr Cys Pro Glu Asp
     290                 295                 300

 gcc tcg gtg ctc acc tgg aat gtc acc aag gct ggc cac gtg gca cag      960
 Ala Ser Val Leu Thr Trp Asn Val Thr Lys Ala Gly His Val Ala Gln
 305                 310                 315                 320

 gcc cca tgt cct gag agc aag agg ggc ata gtg agg agg ctc tgt ggg     1008
 Ala Pro Cys Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly
                 325                 330                 335

 gct gac gga gtc tgg ggg ccg gtc cac agc agc tgc aca gat gcg agg     1056
 Ala Asp Gly Val Trp Gly Pro Val His Ser Ser Cys Thr Asp Ala Arg
             340                 345                 350

 ctc ctg gcc ttg ttc act aga acc aag ctg ctg cag gca ggc cag ggc     1104
 Leu Leu Ala Leu Phe Thr Arg Thr Lys Leu Leu Gln Ala Gly Gln Gly
         355                 360                 365

 agt cct gct gag gag gtg cca cag atc ctg gca cag ctg cca ggg cag     1152
 Ser Pro Ala Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln
     370                 375                 380

 gcg gca gag gca agt tca ccc tcc gac tta ctg acc ctg ctg agc acc     1200
 Ala Ala Glu Ala Ser Ser Pro Ser Asp Leu Leu Thr Leu Leu Ser Thr
 385                 390                 395                 400

 atg aaa tac gtg gcc aag gtg gtg gca gag gcc aga ata cag ctt gac     1248
 Met Lys Tyr Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp
                 405                 410                 415

 cgc aga gcc ctg aag aat ctc ctg att gcc aca gac aag gtc cta gat     1296
 Arg Arg Ala Leu Lys Asn Leu Leu Ile Ala Thr Asp Lys Val Leu Asp
             420                 425                 430

 atg gac acc agg tct ctg tgg acc ctg gcc caa gcc cgg aag ccc tgg     1344
 Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp
         435                 440                 445

 gca ggc tcg act ctc ctg ctg gct gtg gag acc ctg gca tgc agc ctg     1392
 Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu
     450                 455                 460

 tgc cca cag gac cac ccc ttc gcc ttc agc tta ccc aat gtg ctg ctg     1440
 Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu
 465                 470                 475                 480

 cag agc cag ctg ttt gga ccc acg ttt cct gct gac tac agc atc tcc     1488
 Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser
                 485                 490                 495

 ttc cct act cgg ccc cca ctg cag gct cag att ccc agg cac tca ctg     1536
 Phe Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu
             500                 505                 510

 gcc cca ttg gtc cgt aat gga act gaa ata agt att act agc ctg gtg     1584
 Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val
         515                 520                 525

 ctg cga aaa ctg gac cac ctt ctg ccc tca aac tat gga caa ggg ctg     1632
 Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu
     530                 535                 540

 ggg gat tcc ctc tat gcc act cct ggc ctg gtc ctt gtc att tcc atc     1680
 Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile
 545                 550                 555                 560

 atg gca ggt gac cgg gcc ttc agc cag gga gag gtc atc atg gac ttt     1728
 Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe
                 565                 570                 575

 ggg aac aca gat ggt tcc cct cac tgt gtc ttc tgg gat cac agt ctc     1776
 Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu
             580                 585                 590

 ttc cag ggc agg ggg ggt tgg tcc aaa gaa ggg tgc cag gca cag gtg     1824
 Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val
         595                 600                 605

 gcc agt gcc agc ccc act gct cag tgc ctc tgc cag cac ctc act gcc     1872
 Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala
     610                 615                 620

 ttc tcc gtc ctc atg tcc cca cac act gtt ccg gaa gaa ccc gct ctg     1920
 Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu
 625                 630                 635                 640

 gcg ctg ctg act caa gtg ggc ttg gga gct tcc ata ctg gcg ctg ctt     1968
 Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu
                 645                 650                 655

 gtg tgc ctg ggt gtg tac tgg ctg gtg tgg aga gtc gtg gtg cgg aac     2016
 Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn
             660                 665                 670

 aag atc tcc tat ttc cgc cac gcc gcc ctg ctc aac atg gtg ttc tgc     2064
 Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys
         675                 680                 685

 ttg ctg gcc gca gac act tgc ttc ctg ggc gcc cca ttc ctc tct cca     2112
 Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro
     690                 695                 700

 ggg ccc cga agc ccg ctc tgc ctt gct gcc gcc ttc ctc tgt cat ttc     2160
 Gly Pro Arg Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe
 705                 710                 715                 720

 ctc tac ctg gcc acc ttt ttc tgg atg ctg gcg cag gcc ctg gtg ttg     2208
 Leu Tyr Leu Ala Thr Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu
                 725                 730                 735

 gcc cac cag ctg ctc ttt gtc ttt cac cag ctg gca aag cac cga gtt     2256
 Ala His Gln Leu Leu Phe Val Phe His Gln Leu Ala Lys His Arg Val
             740                 745                 750

 ctc ccc ctc atg gtg ctc ctg ggc tac ctg tgc cca ctg ggg ttg gca     2304
 Leu Pro Leu Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala
         755                 760                 765

 ggt gtc acc ctg ggg ctc tac cta cct caa ggg caa tac ctg agg gag     2352
 Gly Val Thr Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu
     770                 775                 780

 ggg gaa tgc tgg ttg gat ggg aag gga ggg gcg tta tac acc ttc gtg     2400
 Gly Glu Cys Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Thr Phe Val
 785                 790                 795                 800

 ggg cca gtg ctg gcc atc ata ggc gtg aat ggg ctg gta cta gcc atg     2448
 Gly Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met
                 805                 810                 815

 gcc atg ctg aag ttg ctg aga cct tcg ctg tca gag gga ccc cca gca     2496
 Ala Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala
             820                 825                 830

 gag aag cgc caa gct ctg ctg ggg gtg atc aaa gcc ctg ctc att ctt     2544
 Glu Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu
         835                 840                 845

 aca ccc atc ttt ggc ctc acc tgg ggg ctg ggc ctg gcc act ctg tta     2592
 Thr Pro Ile Phe Gly Leu Thr Trp Gly Leu Gly Leu Ala Thr Leu Leu
     850                 855                 860

 gag gaa gtc tcc acg gtc cct cat tac atc ttc acc att ctc aac acc     2640
 Glu Glu Val Ser Thr Val Pro His Tyr Ile Phe Thr Ile Leu Asn Thr
 865                 870                 875                 880

 ctc cag ggc gtc ttc atc cta ttg ttt ggt tgc ctc atg gac agg aag     2688
 Leu Gln Gly Val Phe Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys
                 885                 890                 895

 ata caa gaa gct ttg cgc aaa cgc ttc tgc cgc gcc caa gcc ccc agc     2736
 Ile Gln Glu Ala Leu Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser
             900                 905                 910

 tcc acc atc tcc ctg gcc aca aat gaa ggc tgc atc ttg gaa cac agc     2784
 Ser Thr Ile Ser Leu Ala Thr Asn Glu Gly Cys Ile Leu Glu His Ser
         915                 920                 925

 aaa gga gga agc gac act gcc agg tga gaact aggctttctc aggggcagcg     2836
 Lys Gly Gly Ser Asp Thr Ala Arg 
     930                 935

 taagcagggt ggattgagga cggtgtggca aagggcctcc tggcaaagtg ctggagagaa   2896

 gcctcctctt tctataccca gcccacacca aagggtagga aacaggtttt tctagggtag   2956

 ccattgctag atggctggga gacggtggaa catgtcagag agcagaaaac atagcccctt   3016

 atcttaaatt ccaagaaagc aagaagtttc accaccacct gta                     3059




      <210> 66
      <211> 1105
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(812)

      <220>
      <221> misc_feature
      <222> (1)...(1105)
      <223> n = a,t,c or g

      <400> 66
 atcaaaaatt caaattttcc tgtctcatgt tcttttctaa actctgcaga tgacatgaac     60

 ac   atg gag aca aca aat cac tct gcc gtg act gaa ttc ttt ctg gtg     107
      Met Glu Thr Thr Asn His Ser Ala Val Thr Glu Phe Phe Leu Val
        1               5                  10                  15

 ggg ctt tcc caa tat cca gag ctc cag ctt ttt ctg ttc ctg ctc tgc      155
 Gly Leu Ser Gln Tyr Pro Glu Leu Gln Leu Phe Leu Phe Leu Leu Cys
                  20                  25                  30

 ctc atc atg tac atg ata atc ctc ctg gga aat agc ttc ctc att atc      203
 Leu Ile Met Tyr Met Ile Ile Leu Leu Gly Asn Ser Phe Leu Ile Ile
              35                  40                  45

 atc acc atc ttg gat tct cgc ctc cat acc ccc atg tat ttc ttt ctt      251
 Ile Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu
          50                  55                  60

 gga aac ctc tca ttc ttg ggc atc tgt tac aca tca tca tcc att cct      299
 Gly Asn Leu Ser Phe Leu Gly Ile Cys Tyr Thr Ser Ser Ser Ile Pro
      65                  70                  75

 cca atg ctt att ata ttt gta tct gag aga aaa tcc atc tcc ttc att      347
 Pro Met Leu Ile Ile Phe Val Ser Glu Arg Lys Ser Ile Ser Phe Ile
  80                  85                  90                  95

 ggc tgt gct ctg cag atg gtt gtg tcc ctt ggc ttg ggc tcc att gag      395
 Gly Cys Ala Leu Gln Met Val Val Ser Leu Gly Leu Gly Ser Ile Glu
                 100                 105                 110

 tgt atc ctc ctg gct gtg atg gcc tat gac cgc tat gtg gcc atc tgc      443
 Cys Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys
             115                 120                 125

 aac cca ctg agg tac tcc atc atc atg aac aga gtg ctg tat gtg caa      491
 Asn Pro Leu Arg Tyr Ser Ile Ile Met Asn Arg Val Leu Tyr Val Gln
         130                 135                 140

 atg gct gca tgg tcc tgg atc ata ggc tgt ctg acc tcc cta ttg cga      539
 Met Ala Ala Trp Ser Trp Ile Ile Gly Cys Leu Thr Ser Leu Leu Arg
     145                 150                 155

 aca gtt ctg aca atg atg ttg cct ttc tgt ggg aat aat atc att gat      587
 Thr Val Leu Thr Met Met Leu Pro Phe Cys Gly Asn Asn Ile Ile Asp
 160                 165                 170                 175

 cat ctt acc tcg cac ttg act gtg gtc atc tta ttc tat ggt tca gtt      635
 His Leu Thr Ser His Leu Thr Val Val Ile Leu Phe Tyr Gly Ser Val
                 180                 185                 190

 ctt ttc atg cac atg aag ccc aaa tca aag ttc aca aca gca tct gat      683
 Leu Phe Met His Met Lys Pro Lys Ser Lys Phe Thr Thr Ala Ser Asp
             195                 200                 205

 gaa atc att gga ttg tct tat gaa gtg atc acc cca atg aac ccc atc      731
 Glu Ile Ile Gly Leu Ser Tyr Glu Val Ile Thr Pro Met Asn Pro Ile
         210                 215                 220

 atc tac agc ctg agg aat aag gag ata aaa gaa gct gtg aag aaa atc      779
 Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Glu Ala Val Lys Lys Ile
     225                 230                 235

 ctc agc aga cac gtg cat cta tgg aaa ata tga aaggcctt gaggcatgtg      830
 Leu Ser Arg His Val His Leu Trp Lys Ile 
 240                 245

 acgttctcaa caagggatca gatcaggtgt tttgtattca cagataaagt cacagaatct    890

 ggtatcaaga gagtgtgtat gtttgtaaag acaactttgg gattcccatt cttctcatca    950

 cagaatgctc atgtacacct tctgaataat gtctcgtgtg cagagtttca agctgtaggt   1010

 atctgtgctc actgatccca tatagggata aggtttttca tcaagataaa tctcactctt   1070

 ctctactctn tatctctttc tctttcttac tcact                              1105




      <210> 67
      <211> 2237
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(1028)

      <400> 67
 atgcatgtgt gcctgtgtgt gtgtgcctgt gtgtgtgggt gcacatttgt gtgtgtgtgt     60

 gtgcctgtgt gtgtgtgtgc acgtatgtat gtgtgcacac ttgt atg cat gtg tgc     116
                                                  Met His Val Cys
                                                    1

 ctg tgt gtg tgg gtg cac att tgt gtg tgt gtg cct gtg tgt gtg ggt      164
 Leu Cys Val Trp Val His Ile Cys Val Cys Val Pro Val Cys Val Gly
   5                  10                  15                  20

 gca cat ttg tgt gtg tgg gtg cac att tgt gtg tgt gtg cgc ctg tgt      212
 Ala His Leu Cys Val Trp Val His Ile Cys Val Cys Val Arg Leu Cys
                  25                  30                  35

 gtg tgg gtg cac att tgt gtg tgt gtg tgc ctg tgt gtg tgc ctg tgt      260
 Val Trp Val His Ile Cys Val Cys Val Cys Leu Cys Val Cys Leu Cys
              40                  45                  50

 gtg tgg gtg cct gtg tgt gtg ggg cac att tgt gtg tgt gtg tgc ctg      308
 Val Trp Val Pro Val Cys Val Gly His Ile Cys Val Cys Val Cys Leu
          55                  60                  65

 tgt gtg ggt gca cat ttg tgt gtg tgc ctc tgt gtg tgt gcc tgt gtg      356
 Cys Val Gly Ala His Leu Cys Val Cys Leu Cys Val Cys Ala Cys Val
      70                  75                  80

 tgg ggg tgc aca ttt gtg tgt gcg cct gtg tgt ggg ggt gca cat ttg      404
 Trp Gly Cys Thr Phe Val Cys Ala Pro Val Cys Gly Gly Ala His Leu
  85                  90                  95                 100

 tgt gtg cgc ctg tgt gtg tgg gtg cac att tgt gtg tgt gtg cgc ctg      452
 Cys Val Arg Leu Cys Val Trp Val His Ile Cys Val Cys Val Arg Leu
                 105                 110                 115

 tgt ggg tgc ctg tgt gtg tgt ggg gca cat ttg tgt gtg tgt gtg tgc      500
 Cys Gly Cys Leu Cys Val Cys Gly Ala His Leu Cys Val Cys Val Cys
             120                 125                 130

 ctg tgt gtg ggt gca cat ttg tgt gtg tgc ctg tgt gtg tgt gcc tgt      548
 Leu Cys Val Gly Ala His Leu Cys Val Cys Leu Cys Val Cys Ala Cys
         135                 140                 145

 gtg tgg ggg tgc aca ttt gtg tgt gtg tgt gcc tgt gtg tgg ggg tgc      596
 Val Trp Gly Cys Thr Phe Val Cys Val Cys Ala Cys Val Trp Gly Cys
     150                 155                 160

 aca ttt gtg tgt gtg tgt gcc tgt gtg tgt ggg tgc aca ttt gtg tgt      644
 Thr Phe Val Cys Val Cys Ala Cys Val Cys Gly Cys Thr Phe Val Cys
 165                 170                 175                 180

 gtg tgt gcc tgt gtg tgt ggg tgc aca ttt gtg tgt gtg tgc ctg tgt      692
 Val Cys Ala Cys Val Cys Gly Cys Thr Phe Val Cys Val Cys Leu Cys
                 185                 190                 195

 gtg tgg gtg cac att tgt gtg tgt gtg tgc ctg tgt gtg tgg gtg cac      740
 Val Trp Val His Ile Cys Val Cys Val Cys Leu Cys Val Trp Val His
             200                 205                 210

 att tgt gtg tgt gcc tgt gtg tgg gtg cac att tgt gtg tgt gtg cct      788
 Ile Cys Val Cys Ala Cys Val Trp Val His Ile Cys Val Cys Val Pro
         215                 220                 225

 gtg tgt gtg tgc ctg tgt gtg tgg gtg cac att tgt gtg tgt gtg tgc      836
 Val Cys Val Cys Leu Cys Val Trp Val His Ile Cys Val Cys Val Cys
     230                 235                 240

 ctg tgt gtg tgg gtg cac att tgt gtg tgt gtg tgt gcc tgt gtg tgt      884
 Leu Cys Val Trp Val His Ile Cys Val Cys Val Cys Ala Cys Val Cys
 245                 250                 255                 260

 gtt gca ggc cct gga tgc cag aca ctg aat aaa cgc agg aag acg tct      932
 Val Ala Gly Pro Gly Cys Gln Thr Leu Asn Lys Arg Arg Lys Thr Ser
                 265                 270                 275

 gtc ttc att ctc ctc gtg ggt cgc tgg tcc aga aac acc tgg atg gaa      980
 Val Phe Ile Leu Leu Val Gly Arg Trp Ser Arg Asn Thr Trp Met Glu
             280                 285                 290

 agt gct ctg cag gaa cgg tgc ctc tgc ctg tgg cgg gga ccc tgg tga     1028
 Ser Ala Leu Gln Glu Arg Cys Leu Cys Leu Trp Arg Gly Pro Trp 
         295                 300                 305

 gcggatgggc cagccccacg tgtcttccgg ccactcagca tgcagtgttt ccaggggcac   1088

 taagagacca aaatcgagat atgattagct gtaggatgtc atctaatcac agatcatccc   1148

 gaggctaatt tatctccccc atgaccataa cacatcaaaa agttgacttt ttgcagctcg   1208

 gctgtgcctc atcttcccac gaagccccga caggcacatc cagtgaggaa ccacagtggg   1268

 agtcctgtgg cagggtcacc ccacttccga tgccctccag ctgcatcttg gcacgaaaaa   1328

 ggctgcccag ttctcatgcc ctttcaagtc ccgggctggg gggtagcagt ggaggctggg   1388

 gttaaccgcc gtccgtctca aaggcctcat tgtggagctg caaacacgaa cgtccttgaa   1448

 atgtgagggg acagtgctct ggggcagggg ctgctcactg gttcatggcc agaggtgagc   1508

 gggctctggg tctgggtctg tgaggtgctg tggacgtcgg gggtgctcct ggggcaggga   1568

 cacagccacg gccctcacac cagtggagcc gtcttccttc ccgaggcaga ggcttggcct   1628

 tctcacacct tgggaccctt ctctcccctg tgctcatgct ggaagcacag cgtgaggggg   1688

 caaaggtcat gggaggcaaa aggctgggct gaggccgagg ctctgtggct gtggccggat   1748

 accaggtcct gtggtggtgt gggcagggcg cgctctctcc tctgagcagc ctggggctgc   1808

 gtgtgtgaac agaaacaggc ctgccgattt gaagatggtt tgaccaagtc tcccaaagct   1868

 gaagagaggt ccctgcccat gtcccccggg tggcaatcca cagacgcacc tgtgtccatc   1928

 agacggtatc gttgataggg agtctgaagc cacccagacg tggtctgttc acgccgtgga   1988

 caccacggtc tgaggcagac ggttacagcc accggcatag gcgaatctca gccagagaga   2048

 gtgaactggg acaccattca cgtgatgggc cagatgggct ggcagcggct cgctggagcc   2108

 gtccgggtgg gaacgctgtg tctgttggtc tggtgctgct tatgtggctg gttcaggtct   2168

 gtcatccgtc aacctgcata tttatcactg gtgcattttc atgtatgttg tacctcaatt   2228

 aaaacattt                                                           2237




      <210> 68
      <211> 1125
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(1125)

      <400> 68
 agagagagac tgagattgag actgagaaag agaaagagag tctttgcata aagctgtaac     60

 ctgtaatcct ctgccctccc tctcaagcat tttgtagtta tttgctaata ccacctataa    120

 tgtggactgt cattactatc ccaggtctgc atcttgtcct tgtggtccac gggaagc       177                                                                 
 atg tcc ata acc aaa gcc tgg aac agc tca tca gtg acc atg ttc atc      225
 Met Ser Ile Thr Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile
   1               5                  10                  15

 ctc ctg gga ttc aca gac cat cca gaa ctc cag gcc ctc ctc ttt gtg      273
 Leu Leu Gly Phe Thr Asp His Pro Glu Leu Gln Ala Leu Leu Phe Val
              20                  25                  30

 acc ttc ctg ggc atc tat ctt acc acc ctg gcc tgg aac ctg gcc ctc      321
 Thr Phe Leu Gly Ile Tyr Leu Thr Thr Leu Ala Trp Asn Leu Ala Leu
          35                  40                  45

 att ttt ctg atc aga ggt gac acc cat ctg cac aca ccc atg tac ttc      369
 Ile Phe Leu Ile Arg Gly Asp Thr His Leu His Thr Pro Met Tyr Phe
      50                  55                  60

 ttc cta agc aac tta tct ttc att gac atc tgc tac tct tct gct gtg      417
 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Ala Val
  65                  70                  75                  80

 gct ccc aat atg ctc act gac ttc ttc tgg gag cag aag acc ata tca      465
 Ala Pro Asn Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser
                  85                  90                  95

 ttt gtg ggc tgt gct gct cag ttt ttt ttc ttt gtc ggc atg ggt ctg      513
 Phe Val Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Gly Met Gly Leu
             100                 105                 110

 tct gag tgc ctc ctc ctg act gct atg gca tac gac cga tat gca gcc      561
 Ser Glu Cys Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala
         115                 120                 125

 atc tcc agc ccc ctt ctc tac ccc act atc atg acc cag ggc ctc tgt      609
 Ile Ser Ser Pro Leu Leu Tyr Pro Thr Ile Met Thr Gln Gly Leu Cys
     130                 135                 140

 aca cgc atg gtg gtt ggg gca tat gtt ggt ggc ttc ctg agc tcc ctg      657
 Thr Arg Met Val Val Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu
 145                 150                 155                 160

 atc cag gcc agc tcc ata ttt agg ctt cac ttt tgc gga ccc aac atc      705
 Ile Gln Ala Ser Ser Ile Phe Arg Leu His Phe Cys Gly Pro Asn Ile
                 165                 170                 175

 atc aac cac ttc ttc tgc gac ctc cca cca gtc ctg gct ctg tct tgc      753
 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys
             180                 185                 190

 tct gac acc ttc ctc agt caa gtg gtg aat ttc ctc gtg gtg gtc act      801
 Ser Asp Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Val Thr
         195                 200                 205

 gtc gga gga aca tcg ttc ctc caa ctc ctt atc tcc tat ggt tac ata      849
 Val Gly Gly Thr Ser Phe Leu Gln Leu Leu Ile Ser Tyr Gly Tyr Ile
     210                 215                 220

 gtg tct gcg gtc ctg aag atc cct tca gca gag ggc cga tgg aaa gcc      897
 Val Ser Ala Val Leu Lys Ile Pro Ser Ala Glu Gly Arg Trp Lys Ala
 225                 230                 235                 240

 tgc aac acg tgt gcc tcg cat ctg atg gtg gtg act ctg ctg ttt ggg      945
 Cys Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly
                 245                 250                 255

 aca gcc ctt ttc gtg tac ttg cga ccc agc tcc agc tac ttg cta ggc      993
 Thr Ala Leu Phe Val Tyr Leu Arg Pro Ser Ser Ser Tyr Leu Leu Gly
             260                 265                 270

 agg gac aag gtg gtg tct gtt ttc tat tca ttg gtg atc ccc atg ctg     1041
 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu
         275                 280                 285

 aac cct ctc att tac agt ttg agg aac aaa gag atc aag gat gcc ctg     1089
 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu
     290                 295                 300

 tgg aag gtg ttg gaa agg aag aaa gtg ttt tct tag                     1125
 Trp Lys Val Leu Glu Arg Lys Lys Val Phe Ser 
 305                 310                 315





      <210> 69
      <211> 2400
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(2400)

      <400> 69
 gct  atg ggg agc agg ttc ctc ctg gtc ctg ctc tca ggt ctc act gtc      48
      Met Gly Ser Arg Phe Leu Leu Val Leu Leu Ser Gly Leu Thr Val
        1               5                  10                  15

 tta ctg gct ctg cca gga tca gaa gcc aag aat tct gga gct tcc tgt       96
 Leu Leu Ala Leu Pro Gly Ser Glu Ala Lys Asn Ser Gly Ala Ser Cys
                  20                  25                  30

 cct cca tgc cct aaa tat gcc agc tgc cac aac agc acc cac tgt act      144
 Pro Pro Cys Pro Lys Tyr Ala Ser Cys His Asn Ser Thr His Cys Thr
              35                  40                  45

 tgt gaa gat ggc ttt cgg gcc agg tct ggc agg aca tac ttt cat gat      192
 Cys Glu Asp Gly Phe Arg Ala Arg Ser Gly Arg Thr Tyr Phe His Asp
          50                  55                  60

 tcc tct gag aag tgt gaa gat att aat gaa tgt gaa acc ggg ctg gca      240
 Ser Ser Glu Lys Cys Glu Asp Ile Asn Glu Cys Glu Thr Gly Leu Ala
      65                  70                  75

 aag tgc aag tat aaa gca tat tgt agg aat aaa gtt gga ggt tac atc      288
 Lys Cys Lys Tyr Lys Ala Tyr Cys Arg Asn Lys Val Gly Gly Tyr Ile
  80                  85                  90                  95

 tgt agc tgt ttg gta aaa tat act tta ttc aac ttt ctg gct ggt att      336
 Cys Ser Cys Leu Val Lys Tyr Thr Leu Phe Asn Phe Leu Ala Gly Ile
                 100                 105                 110

 ata gat tat gat cat ccg gat tgt tac gag aat tct gga gag aac aat      384
 Ile Asp Tyr Asp His Pro Asp Cys Tyr Glu Asn Ser Gly Glu Asn Asn
             115                 120                 125

 agt caa ggg acg aca cag tca aac gtg gat att tgg gtg agt ggg gtg      432
 Ser Gln Gly Thr Thr Gln Ser Asn Val Asp Ile Trp Val Ser Gly Val
         130                 135                 140

 aag cct gga ttt ggg aaa cag ctg gaa aat ctg aga aga aat gga agc      480
 Lys Pro Gly Phe Gly Lys Gln Leu Glu Asn Leu Arg Arg Asn Gly Ser
     145                 150                 155

 aga gag gac ttt gca aga agg gct act caa cta att caa agc gtg gag      528
 Arg Glu Asp Phe Ala Arg Arg Ala Thr Gln Leu Ile Gln Ser Val Glu
 160                 165                 170                 175

 ttg agc atc tgg aat gcg agt ttt gct tct cca gga aag ggt caa att      576
 Leu Ser Ile Trp Asn Ala Ser Phe Ala Ser Pro Gly Lys Gly Gln Ile
                 180                 185                 190

 tct gaa ttt gat ata gtc tat gaa acc aag agg tgc aat gag aca agg      624
 Ser Glu Phe Asp Ile Val Tyr Glu Thr Lys Arg Cys Asn Glu Thr Arg
             195                 200                 205

 gag aat gct ttt ctg gaa gct gga aat aac acc atg gat atc aac tgt      672
 Glu Asn Ala Phe Leu Glu Ala Gly Asn Asn Thr Met Asp Ile Asn Cys
         210                 215                 220

 gct gat gct tta aaa gga aac cta aga gat tgg aaa aca aat gtt ctc      720
 Ala Asp Ala Leu Lys Gly Asn Leu Arg Asp Trp Lys Thr Asn Val Leu
     225                 230                 235

 tac aag gtc cag aga gta aat atg tta ggc ctt ttg ttc cag atg acc      768
 Tyr Lys Val Gln Arg Val Asn Met Leu Gly Leu Leu Phe Gln Met Thr
 240                 245                 250                 255

 ttt gtc ata act act cag ctc tgc cat cag agt gtg aaa gca gcc att      816
 Phe Val Ile Thr Thr Gln Leu Cys His Gln Ser Val Lys Ala Ala Ile
                 260                 265                 270

 gat gat gtg tca gtg aag gaa gag cac tgc agt tgc cct atc act tat      864
 Asp Asp Val Ser Val Lys Glu Glu His Cys Ser Cys Pro Ile Thr Tyr
             275                 280                 285

 caa tct ctt ggg gat att ctg aat gca tcc ttt ttt agt aaa cga aaa      912
 Gln Ser Leu Gly Asp Ile Leu Asn Ala Ser Phe Phe Ser Lys Arg Lys
         290                 295                 300

 ggg atg cag gaa gta aaa ctg aac tct tac gtt gtg agc ggc acc gtc      960
 Gly Met Gln Glu Val Lys Leu Asn Ser Tyr Val Val Ser Gly Thr Val
     305                 310                 315

 ggt ttg aag gaa aaa att tcc ctc tct gaa cct gtg ttc ctg act ttt     1008
 Gly Leu Lys Glu Lys Ile Ser Leu Ser Glu Pro Val Phe Leu Thr Phe
 320                 325                 330                 335

 cgc cat aat cag cct ggt gac aag aga aca aaa cat atc tgt gtc tac     1056
 Arg His Asn Gln Pro Gly Asp Lys Arg Thr Lys His Ile Cys Val Tyr
                 340                 345                 350

 tgg gag gga tca gag gga ggc cgc tgg tcc acg gag ggc tgc tct cat     1104
 Trp Glu Gly Ser Glu Gly Gly Arg Trp Ser Thr Glu Gly Cys Ser His
             355                 360                 365

 gtg cac agc aac ggt tct tac acc aaa tgc aag tgc ttc cat ctg tcc     1152
 Val His Ser Asn Gly Ser Tyr Thr Lys Cys Lys Cys Phe His Leu Ser
         370                 375                 380

 agc ttt gcc gtc ctc gtg gct ctt gcc ccc aag gag gac cct gtg ctg     1200
 Ser Phe Ala Val Leu Val Ala Leu Ala Pro Lys Glu Asp Pro Val Leu
     385                 390                 395

 acc gtg atc acc cag gtg ggg ctg acc atc tct ctg ctg tgc ctc ttc     1248
 Thr Val Ile Thr Gln Val Gly Leu Thr Ile Ser Leu Leu Cys Leu Phe
 400                 405                 410                 415

 ctg gcc atc ctc acc ttc ctc ctg tgc cgg ccc atc cag aac acc agc     1296
 Leu Ala Ile Leu Thr Phe Leu Leu Cys Arg Pro Ile Gln Asn Thr Ser
                 420                 425                 430

 acc tcc ctc cat cta gag ctc tcc ctc tgc ctc ttc ctg gcc cac ctc     1344
 Thr Ser Leu His Leu Glu Leu Ser Leu Cys Leu Phe Leu Ala His Leu
             435                 440                 445

 ctg ttc ctg acg ggc atc aac aga act gag cct gag gtg ctg tgc tcc     1392
 Leu Phe Leu Thr Gly Ile Asn Arg Thr Glu Pro Glu Val Leu Cys Ser
         450                 455                 460

 atc att gca ggg ctg ctg cac ttc ctc tac ctg gct tgc ttc acc tgg     1440
 Ile Ile Ala Gly Leu Leu His Phe Leu Tyr Leu Ala Cys Phe Thr Trp
     465                 470                 475

 atg ctc ctg gaa ggg ctg cac ctc ttc ctc acc gtc agg aac ctc aag     1488
 Met Leu Leu Glu Gly Leu His Leu Phe Leu Thr Val Arg Asn Leu Lys
 480                 485                 490                 495

 gtg gcc aac tac acc agc acg ggc aga ttc aag aag agg ttc atg tac     1536
 Val Ala Asn Tyr Thr Ser Thr Gly Arg Phe Lys Lys Arg Phe Met Tyr
                 500                 505                 510

 cct gta ggc tac ggg atc cca gct gtg att att gct gtg tca gca ata     1584
 Pro Val Gly Tyr Gly Ile Pro Ala Val Ile Ile Ala Val Ser Ala Ile
             515                 520                 525

 gtt gga ccc cag aat tat gga aca ttt act cac tgt tgg ctc aag ctt     1632
 Val Gly Pro Gln Asn Tyr Gly Thr Phe Thr His Cys Trp Leu Lys Leu
         530                 535                 540

 gat aaa gga ttc atc tgg agc ttc atg ggg cca gta gca gtc att atc     1680
 Asp Lys Gly Phe Ile Trp Ser Phe Met Gly Pro Val Ala Val Ile Ile
     545                 550                 555

 ttg ata aac ctg gtg ttc tac ttc caa gtt ctg tgg att ttg aga agc     1728
 Leu Ile Asn Leu Val Phe Tyr Phe Gln Val Leu Trp Ile Leu Arg Ser
 560                 565                 570                 575

 aaa ctt tcc tcc ctc aat aaa gaa gtt tcc acc att cag gac acc aga     1776
 Lys Leu Ser Ser Leu Asn Lys Glu Val Ser Thr Ile Gln Asp Thr Arg
                 580                 585                 590

 gtc atg aca ttt aaa gcc att tct cag cta ttt atc ctg ggc tgt tct     1824
 Val Met Thr Phe Lys Ala Ile Ser Gln Leu Phe Ile Leu Gly Cys Ser
             595                 600                 605

 tgg ggc ctt ggt ttt ttt atg gtt gaa gaa gta ggg aag acg att gga     1872
 Trp Gly Leu Gly Phe Phe Met Val Glu Glu Val Gly Lys Thr Ile Gly
         610                 615                 620

 tca atc att gca tac tca ttc acc atc atc aac acc ctt cag gga gtg     1920
 Ser Ile Ile Ala Tyr Ser Phe Thr Ile Ile Asn Thr Leu Gln Gly Val
     625                 630                 635

 ttg ctc ttt gtg gta cac tgt ctc ctt aat cgc cag atc aac tcc ctt     1968
 Leu Leu Phe Val Val His Cys Leu Leu Asn Arg Gln Ile Asn Ser Leu
 640                 645                 650                 655

 ctc ctg acc tgg acc ttg tgg atc ctg agg cag agg ctt tcc agt gtt     2016
 Leu Leu Thr Trp Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val
                 660                 665                 670

 aat gcc gaa gtc tca acg cta aaa gac acc agg tta ctg acc ttc aag     2064
 Asn Ala Glu Val Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys
             675                 680                 685

 gcc ttt gcc cag ctc ttc atc ctg ggc tgc tcc tgg gtg ctg ggc att     2112
 Ala Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile
         690                 695                 700

 ttt cag att gga cct gtg gca ggt gtc atg gct tac ctg ttc acc atc     2160
 Phe Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile
     705                 710                 715

 atc aac agc ctg cag ggg gcc ttc atc ttc ctc atc cac tgt ctg ctc     2208
 Ile Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu
 720                 725                 730                 735

 aac ggc cag gta cga gaa gaa tac aag agg tgg atc act ggg aag acg     2256
 Asn Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr
                 740                 745                 750

 aag ccc agc tcc cag tcc cag acc tca agg atc ttg ctg tcc tcc atg     2304
 Lys Pro Ser Ser Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met
             755                 760                 765

 cca tcc gct tcc aag acg tca att att ggc tac att gcc ccg aca atg     2352
 Pro Ser Ala Ser Lys Thr Ser Ile Ile Gly Tyr Ile Ala Pro Thr Met
         770                 775                 780

 gta ggg cag tgc gtc acc ttc cag atg gag cac ttc ctg ttc agc tga     2400
 Val Gly Gln Cys Val Thr Phe Gln Met Glu His Phe Leu Phe Ser 
     785                 790                 795





      <210> 70
      <211> 2112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(2112)

      <400> 70
 gct  atg ggg agc agg ttc ctc ctg gtc ctg ctc tca ggt ctc act gtc      48
      Met Gly Ser Arg Phe Leu Leu Val Leu Leu Ser Gly Leu Thr Val
        1               5                  10                  15

 tta ctg gct ctg cca gga tca gaa gcc aag aat tct gga gag aac aat       96
 Leu Leu Ala Leu Pro Gly Ser Glu Ala Lys Asn Ser Gly Glu Asn Asn
                  20                  25                  30

 agt caa ggg acg aca cag tca aac gtg gat att tgg gtg agt ggg gtg      144
 Ser Gln Gly Thr Thr Gln Ser Asn Val Asp Ile Trp Val Ser Gly Val
              35                  40                  45

 aag cct gga ttt ggg aaa cag ctg gaa aat ctg aga aga aat gga agc      192
 Lys Pro Gly Phe Gly Lys Gln Leu Glu Asn Leu Arg Arg Asn Gly Ser
          50                  55                  60

 aga gag gac ttt gca aga agg gct act caa cta att caa agc gtg gag      240
 Arg Glu Asp Phe Ala Arg Arg Ala Thr Gln Leu Ile Gln Ser Val Glu
      65                  70                  75

 ttg agc atc tgg aat gcg agt ttt gct tct cca gga aag ggt caa att      288
 Leu Ser Ile Trp Asn Ala Ser Phe Ala Ser Pro Gly Lys Gly Gln Ile
  80                  85                  90                  95

 tct gaa ttt gat ata gtc tat gaa acc aag agg tgc aat gag aca agg      336
 Ser Glu Phe Asp Ile Val Tyr Glu Thr Lys Arg Cys Asn Glu Thr Arg
                 100                 105                 110

 gag aat gct ttt ctg gaa gct gga aat aac acc atg gat atc aac tgt      384
 Glu Asn Ala Phe Leu Glu Ala Gly Asn Asn Thr Met Asp Ile Asn Cys
             115                 120                 125

 gct gat gct tta aaa gga aac cta aga gat tgg aaa aca aat gtt ctc      432
 Ala Asp Ala Leu Lys Gly Asn Leu Arg Asp Trp Lys Thr Asn Val Leu
         130                 135                 140

 tac aag gtc cag aga gta aat atg tta ggc ctt ttg ttc cag atg acc      480
 Tyr Lys Val Gln Arg Val Asn Met Leu Gly Leu Leu Phe Gln Met Thr
     145                 150                 155

 ttt gtc ata act act cag ctc tgc cat cag agt gtg aaa gca gcc att      528
 Phe Val Ile Thr Thr Gln Leu Cys His Gln Ser Val Lys Ala Ala Ile
 160                 165                 170                 175

 gat gat gtg tca gtg aag gaa gag cac tgc agt tgc cct atc act tat      576
 Asp Asp Val Ser Val Lys Glu Glu His Cys Ser Cys Pro Ile Thr Tyr
                 180                 185                 190

 caa tct ctt ggg gat att ctg aat gca tcc ttt ttt agt aaa cga aaa      624
 Gln Ser Leu Gly Asp Ile Leu Asn Ala Ser Phe Phe Ser Lys Arg Lys
             195                 200                 205

 ggg atg cag gaa gta aaa ctg aac tct tac gtt gtg agc ggc acc gtc      672
 Gly Met Gln Glu Val Lys Leu Asn Ser Tyr Val Val Ser Gly Thr Val
         210                 215                 220

 ggt ttg aag gaa aaa att tcc ctc tct gaa cct gtg ttc ctg act ttt      720
 Gly Leu Lys Glu Lys Ile Ser Leu Ser Glu Pro Val Phe Leu Thr Phe
     225                 230                 235

 cgc cat aat cag cct ggt gac aag aga aca aaa cat atc tgt gtc tac      768
 Arg His Asn Gln Pro Gly Asp Lys Arg Thr Lys His Ile Cys Val Tyr
 240                 245                 250                 255

 tgg gag gga tca gag gga ggc cgc tgg tcc acg gag ggc tgc tct cat      816
 Trp Glu Gly Ser Glu Gly Gly Arg Trp Ser Thr Glu Gly Cys Ser His
                 260                 265                 270

 gtg cac agc aac ggt tct tac acc aaa tgc aag tgc ttc cat ctg tcc      864
 Val His Ser Asn Gly Ser Tyr Thr Lys Cys Lys Cys Phe His Leu Ser
             275                 280                 285

 agc ttt gcc gtc ctc gtg gct ctt gcc ccc aag gag gac cct gtg ctg      912
 Ser Phe Ala Val Leu Val Ala Leu Ala Pro Lys Glu Asp Pro Val Leu
         290                 295                 300

 acc gtg atc acc cag gtg ggg ctg acc atc tct ctg ctg tgc ctc ttc      960
 Thr Val Ile Thr Gln Val Gly Leu Thr Ile Ser Leu Leu Cys Leu Phe
     305                 310                 315

 ctg gcc atc ctc acc ttc ctc ctg tgc cgg ccc atc cag aac acc agc     1008
 Leu Ala Ile Leu Thr Phe Leu Leu Cys Arg Pro Ile Gln Asn Thr Ser
 320                 325                 330                 335

 acc tcc ctc cat cta gag ctc tcc ctc tgc ctc ttc ctg gcc cac ctc     1056
 Thr Ser Leu His Leu Glu Leu Ser Leu Cys Leu Phe Leu Ala His Leu
                 340                 345                 350

 ctg ttc ctg acg ggc atc aac aga act gag cct gag gtg ctg tgc tcc     1104
 Leu Phe Leu Thr Gly Ile Asn Arg Thr Glu Pro Glu Val Leu Cys Ser
             355                 360                 365

 atc att gca ggg ctg ctg cac ttc ctc tac ctg gct tgc ttc acc tgg     1152
 Ile Ile Ala Gly Leu Leu His Phe Leu Tyr Leu Ala Cys Phe Thr Trp
         370                 375                 380

 atg ctc ctg gaa ggg ctg cac ctc ttc ctc acc gtc agg aac ctc aag     1200
 Met Leu Leu Glu Gly Leu His Leu Phe Leu Thr Val Arg Asn Leu Lys
     385                 390                 395

 gtg gcc aac tac acc agc acg ggc aga ttc aag aag agg ttc atg tac     1248
 Val Ala Asn Tyr Thr Ser Thr Gly Arg Phe Lys Lys Arg Phe Met Tyr
 400                 405                 410                 415

 cct gta ggc tac ggg atc cca gct gtg att att gct gtg tca gca ata     1296
 Pro Val Gly Tyr Gly Ile Pro Ala Val Ile Ile Ala Val Ser Ala Ile
                 420                 425                 430

 gtt gga ccc cag aat tat gga aca ttt act cac tgt tgg ctc aag ctt     1344
 Val Gly Pro Gln Asn Tyr Gly Thr Phe Thr His Cys Trp Leu Lys Leu
             435                 440                 445

 gat aaa gga ttc atc tgg agc ttc atg ggg cca gta gca gtc att atc     1392
 Asp Lys Gly Phe Ile Trp Ser Phe Met Gly Pro Val Ala Val Ile Ile
         450                 455                 460

 ttg ata aac ctg gtg ttc tac ttc caa gtt ctg tgg att ttg aga agc     1440
 Leu Ile Asn Leu Val Phe Tyr Phe Gln Val Leu Trp Ile Leu Arg Ser
     465                 470                 475

 aaa ctt tcc tcc ctc aat aaa gaa gtt tcc acc att cag gac acc aga     1488
 Lys Leu Ser Ser Leu Asn Lys Glu Val Ser Thr Ile Gln Asp Thr Arg
 480                 485                 490                 495

 gtc atg aca ttt aaa gcc att tct cag cta ttt atc ctg ggc tgt tct     1536
 Val Met Thr Phe Lys Ala Ile Ser Gln Leu Phe Ile Leu Gly Cys Ser
                 500                 505                 510

 tgg ggc ctt ggt ttt ttt atg gtt gaa gaa gta ggg aag acg att gga     1584
 Trp Gly Leu Gly Phe Phe Met Val Glu Glu Val Gly Lys Thr Ile Gly
             515                 520                 525

 tca atc att gca tac tca ttc acc atc atc aac acc ctt cag gga gtg     1632
 Ser Ile Ile Ala Tyr Ser Phe Thr Ile Ile Asn Thr Leu Gln Gly Val
         530                 535                 540

 ttg ctc ttt gtg gta cac tgt ctc ctt aat cgc cag atc aac tcc ctt     1680
 Leu Leu Phe Val Val His Cys Leu Leu Asn Arg Gln Ile Asn Ser Leu
     545                 550                 555

 ctc ctg acc tgg acc ttg tgg atc ctg agg cag agg ctt tcc agt gtt     1728
 Leu Leu Thr Trp Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val
 560                 565                 570                 575

 aat gcc gaa gtc tca acg cta aaa gac acc agg tta ctg acc ttc aag     1776
 Asn Ala Glu Val Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys
                 580                 585                 590

 gcc ttt gcc cag ctc ttc atc ctg ggc tgc tcc tgg gtg ctg ggc att     1824
 Ala Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile
             595                 600                 605

 ttt cag att gga cct gtg gca ggt gtc atg gct tac ctg ttc acc atc     1872
 Phe Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile
         610                 615                 620

 atc aac agc ctg cag ggg gcc ttc atc ttc ctc atc cac tgt ctg ctc     1920
 Ile Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu
     625                 630                 635

 aac ggc cag gta cga gaa gaa tac aag agg tgg atc act ggg aag acg     1968
 Asn Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr
 640                 645                 650                 655

 aag ccc agc tcc cag tcc cag acc tca agg atc ttg ctg tcc tcc atg     2016
 Lys Pro Ser Ser Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met
                 660                 665                 670

 cca tcc gct tcc aag acg tca att att ggc tac att gcc ccg aca atg     2064
 Pro Ser Ala Ser Lys Thr Ser Ile Ile Gly Tyr Ile Ala Pro Thr Met
             675                 680                 685

 gta ggg cag tgc gtc acc ttc cag atg gag cac ttc ctg ttc agc tga     2112
 Val Gly Gln Cys Val Thr Phe Gln Met Glu His Phe Leu Phe Ser 
         690                 695                 700





      <210> 71
      <211> 1389
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (283)..(1389)

      <400> 71
 cctggagaca gggcagcgca gccccagact ccctggaaaa cccagcagtc tggaaaagct     60

 gggtttggac tcacccctct ttgaagagtt ctcaggaagt ttgggggagg ggcgagccgc    120

 gcaccagttc taccggcatc gggcgctgag ggtgagaagg gaccacaagc agcagcaggt    180

 ctcagtgctt gtcatattcc tgctcaccgg tgggctccgg gcacgcccgg cagggtcctg    240

 ggggcgcagg caaggggacg taggcagagt gctccggcca gc   atg gag gga ctg     294
                                                  Met Glu Gly Leu
                                                    1

 gtc ttc ctt aac gcc ctg gcc act cgg ttg ctg ttc ctg ctg cac tcg      342
 Val Phe Leu Asn Ala Leu Ala Thr Arg Leu Leu Phe Leu Leu His Ser
   5                  10                  15                  20

 ctg gtc ggg gtc tgg cga gtg acc gag gtg aag aag gag ccg cgg tac      390
 Leu Val Gly Val Trp Arg Val Thr Glu Val Lys Lys Glu Pro Arg Tyr
                  25                  30                  35

 tgg ctg ctt gcg ctg ctc aac ctc ttg ctc ttc ctg gag act gcg ctc      438
 Trp Leu Leu Ala Leu Leu Asn Leu Leu Leu Phe Leu Glu Thr Ala Leu
              40                  45                  50

 acc ctc aag ttc aag cgc ggc aga ggc tac aaa tgg ttt tca cca gcc      486
 Thr Leu Lys Phe Lys Arg Gly Arg Gly Tyr Lys Trp Phe Ser Pro Ala
          55                  60                  65

 ata ttt tta tat ctg att agc atc gtt cca tca tta tgg ctt ctt gaa      534
 Ile Phe Leu Tyr Leu Ile Ser Ile Val Pro Ser Leu Trp Leu Leu Glu
      70                  75                  80

 ttg cac cat gag acc cag tat tgc agt atc cag gct gaa gga aca tca      582
 Leu His His Glu Thr Gln Tyr Cys Ser Ile Gln Ala Glu Gly Thr Ser
  85                  90                  95                 100

 cag aat acc agc aga aaa gaa gac ttc aat caa aca ttg aca tcc aat      630
 Gln Asn Thr Ser Arg Lys Glu Asp Phe Asn Gln Thr Leu Thr Ser Asn
                 105                 110                 115

 gaa caa acc agt aga gct gat gat ctc att gag acg gcc aaa gtt ttt      678
 Glu Gln Thr Ser Arg Ala Asp Asp Leu Ile Glu Thr Ala Lys Val Phe
             120                 125                 130

 gtg aat aac tta tct aca gta tgt gag aaa gtt tgg aca ttg gga ctc      726
 Val Asn Asn Leu Ser Thr Val Cys Glu Lys Val Trp Thr Leu Gly Leu
         135                 140                 145

 cat cag aca ttc ctg tta atg cta ata att gga aga tgg ctt cta ccc      774
 His Gln Thr Phe Leu Leu Met Leu Ile Ile Gly Arg Trp Leu Leu Pro
     150                 155                 160

 att gga ggc ggg atc act cga gat caa ctc tct caa ctt ctt ctt atg      822
 Ile Gly Gly Gly Ile Thr Arg Asp Gln Leu Ser Gln Leu Leu Leu Met
 165                 170                 175                 180

 ttt gtg ggg aca gcg gct gac ata ctg gaa ttc aca agt gag acc cta      870
 Phe Val Gly Thr Ala Ala Asp Ile Leu Glu Phe Thr Ser Glu Thr Leu
                 185                 190                 195

 gaa gaa caa aat gtg agg aat agt cct gca cta gtc tat gcc atc ctt      918
 Glu Glu Gln Asn Val Arg Asn Ser Pro Ala Leu Val Tyr Ala Ile Leu
             200                 205                 210

 gtt ata tgg act tgg agc atg ctg cag ttt cca ctt gac ctg gca gta      966
 Val Ile Trp Thr Trp Ser Met Leu Gln Phe Pro Leu Asp Leu Ala Val
         215                 220                 225

 cag aac gtt gtg tgc cct gtg tct gtg aca gag agg gga ttc ccc agc     1014
 Gln Asn Val Val Cys Pro Val Ser Val Thr Glu Arg Gly Phe Pro Ser
     230                 235                 240

 ctg ttc ttt tgc cag tac agt gcc gat ctg tgg aac atc gga atc agc     1062
 Leu Phe Phe Cys Gln Tyr Ser Ala Asp Leu Trp Asn Ile Gly Ile Ser
 245                 250                 255                 260

 gcc ttc ata caa gat ggc ccc ttc ctt gtc gtg cgt ctc ata ctg atg     1110
 Ala Phe Ile Gln Asp Gly Pro Phe Leu Val Val Arg Leu Ile Leu Met
                 265                 270                 275

 acc tat ttc aaa gtg atc aat cag atg ctg gtg ttc ttt gcc gcg aag     1158
 Thr Tyr Phe Lys Val Ile Asn Gln Met Leu Val Phe Phe Ala Ala Lys
             280                 285                 290

 aac ttc ctc gtg gtg gtg ttg caa ctc tac cgc ttg gtg gtg ctg gca     1206
 Asn Phe Leu Val Val Val Leu Gln Leu Tyr Arg Leu Val Val Leu Ala
         295                 300                 305

 ttg gca gtc cgt gct tcg ttg aga agt cag tca gaa ggc ctg aaa gga     1254
 Leu Ala Val Arg Ala Ser Leu Arg Ser Gln Ser Glu Gly Leu Lys Gly
     310                 315                 320

 gaa cat ggt tgc cgg gca cag acc tct gag agt ggg ccc tct cag cgg     1302
 Glu His Gly Cys Arg Ala Gln Thr Ser Glu Ser Gly Pro Ser Gln Arg
 325                 330                 335                 340

 gac tgg cag aac gag tct aag gag ggc ctg gct att cct ttg cgg ggc     1350
 Asp Trp Gln Asn Glu Ser Lys Glu Gly Leu Ala Ile Pro Leu Arg Gly
                 345                 350                 355

 tcc cca gtc acc tcc gac gac tcc cac cac acc cct tag                 1389
 Ser Pro Val Thr Ser Asp Asp Ser His His Thr Pro 
             360                 365





      <210> 72
      <211> 1133
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (833)..(1096)

      <400> 72
 ctgggtgaag gcctggtgca gactgtggag gcccgaagtg agaggtggac tgtgtgatcc     60

 cagctctgga gcaagctgta gacggacagc aggacattgg acctctagag caagatgtca    120

 gtaggatgac ctccaccctc cttggacatg aatcctccat ggagggcctg ctggctgaac    180

 atgctgaatc atctccaaca aaacccagcc ccaactttct ctctgatgct ccagcattgg    240

 ggcaggggca tggtggccca tgtagtctcc tgggcctcac catcccagaa gaggagtggg    300

 agccagctca gagaaggaac tgaacccagg agatccatcc acctattagc cctgggcctg    360

 gacctccctg cgatttccca ctcctttctt agtcttcttc cagaaacaga gaaggggatg    420

 tgtgcctggg agaggctctg tctccttcct gctgccagga cctgtgccta gacttagcat    480

 gcccttcact gcagtgtcag gcctttagat gggacccagc gaaaatgtgg cccttctgag    540

 tcacatcacc gacactgagc agtggaaagg ggctatatgt gtatgaatag accacattga    600

 aggagcacaa tgccctcctg tgttgatgcc acttcccagg gtggagacag tggaaaagaa    660

 ccgaggacag gaaaggattg ggtaggtgaa ggggtcaggg gactggtagt cacccaatct    720

 tggagaggtg caaaaagcac tgggggctac ccgttagctg catctgccct ggctgtttgc    780

 ccgttcatgt cacaaactgc cactactatg tacctgcagt ggggttgcag ag    atg     835
                                                              Met
                                                                1

 ggg gag act caa gtc tta ctc ccc agg agc tcc cag ggc cca agg agg      883
 Gly Glu Thr Gln Val Leu Leu Pro Arg Ser Ser Gln Gly Pro Arg Arg
               5                  10                  15

 aga atg ctg cct cct ttc agt ctg gtc tac acc cac ttt ctg gta gcc      931
 Arg Met Leu Pro Pro Phe Ser Leu Val Tyr Thr His Phe Leu Val Ala
          20                  25                  30

 tct ctg ctt cct gta att ctg gct gtt ttt cca gac tca gct caa ata      979
 Ser Leu Leu Pro Val Ile Leu Ala Val Phe Pro Asp Ser Ala Gln Ile
      35                  40                  45

 gtg ccc ctc ctt aag ccc atc cct cgc ccc cag cct gag gtg atc ttt     1027
 Val Pro Leu Leu Lys Pro Ile Pro Arg Pro Gln Pro Glu Val Ile Phe
  50                  55                  60                  65

 ccc tcc tct gaa cta tta gag cag tta ctg tct gtt cag ttc gtt tgg     1075
 Pro Ser Ser Glu Leu Leu Glu Gln Leu Leu Ser Val Gln Phe Val Trp
                  70                  75                  80

 cag gca cac aca gtg gca taa at tctattgttt tgaactctga tttaaaatta     1128
 Gln Ala His Thr Val Ala 
              85

 aattg                                                               1133




      <210> 73
      <211> 587
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(533)

      <400> 73
 tctggtaaaa cttgtataaa    atg aat gtc agg atg ttc tcc ctc atg gtg      50
                          Met Asn Val Arg Met Phe Ser Leu Met Val
                            1               5                  10

 ggc atc ttc tct gtc ctt aat acc acc cag ttc ttc atc ttt gac ctg       98
 Gly Ile Phe Ser Val Leu Asn Thr Thr Gln Phe Phe Ile Phe Asp Leu
                  15                  20                  25

 aac cag aag aca cac att tgc tat gag gcc aag ttc agc atc tac gtg      146
 Asn Gln Lys Thr His Ile Cys Tyr Glu Ala Lys Phe Ser Ile Tyr Val
              30                  35                  40

 gac tca aag tcg gag cta gtc act tgg acc ctg ttc cac agg gct aat      194
 Asp Ser Lys Ser Glu Leu Val Thr Trp Thr Leu Phe His Arg Ala Asn
          45                  50                  55

 atc agc act ggc ctc tcc ctc acc acc atc atc atc ggc tgc ttc ctc      242
 Ile Ser Thr Gly Leu Ser Leu Thr Thr Ile Ile Ile Gly Cys Phe Leu
      60                  65                  70

 ctt tat tgt atc cac aag aat atc tac atg ggg ctg ctg atc tat gcc      290
 Leu Tyr Cys Ile His Lys Asn Ile Tyr Met Gly Leu Leu Ile Tyr Ala
  75                  80                  85                  90

 atg tgg atc atc act tac gag ctc atc aac ttc tcc ata gtc ctg ctc      338
 Met Trp Ile Ile Thr Tyr Glu Leu Ile Asn Phe Ser Ile Val Leu Leu
                  95                 100                 105

 ctc aac ggg atc atc aaa gat cac ttc aag atg ctg agt tat ttg cac      386
 Leu Asn Gly Ile Ile Lys Asp His Phe Lys Met Leu Ser Tyr Leu His
             110                 115                 120

 tgg atc ttc caa atc tca cac atg ctc ctg cac ttt ttc tgt ctg ccc      434
 Trp Ile Phe Gln Ile Ser His Met Leu Leu His Phe Phe Cys Leu Pro
         125                 130                 135

 ttc atc gtc aag cat gca tac aac ctt tac aag gaa tcc cag act gtg      482
 Phe Ile Val Lys His Ala Tyr Asn Leu Tyr Lys Glu Ser Gln Thr Val
     140                 145                 150

 ggc agg aaa cgc cgc cac agg ctc tgc tcc acc att gca gtg aac tta      530
 Gly Arg Lys Arg Arg His Arg Leu Cys Ser Thr Ile Ala Val Asn Leu
 155                 160                 165                 170

 tga ctac ctgtccgtct gggaatgttg taccggaagt taaactgaac catgccagat      587
 






      <210> 74
      <211> 1218
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(888)

      <400> 74
 gctccggagc ggctctgcct tcccgagcgc gggacgcggc gccctggggg aggagggcga     60

 agcgacgcgg cg    atg gct ccg cgg gca ctc ccg ggg tcc gcc gtc cta     108
                  Met Ala Pro Arg Ala Leu Pro Gly Ser Ala Val Leu
                    1               5                  10

 gcc gct gct gtc ttc gtg gga ggc gcc gtg agt tcg ccg ctg gtg gct      156
 Ala Ala Ala Val Phe Val Gly Gly Ala Val Ser Ser Pro Leu Val Ala
          15                  20                  25

 ccg gac aat ggg agc agc cgc aca ttg cac tcc aga aca gag acg acc      204
 Pro Asp Asn Gly Ser Ser Arg Thr Leu His Ser Arg Thr Glu Thr Thr
      30                  35                  40

 ccg tcg ccc agc aac gat act ggg aat gga cac cca gaa tat att gca      252
 Pro Ser Pro Ser Asn Asp Thr Gly Asn Gly His Pro Glu Tyr Ile Ala
  45                  50                  55                  60

 tac gcg ctt gtc cct gtg ttc ttt atc atg ggt ctc ttt ggc gtc ctc      300
 Tyr Ala Leu Val Pro Val Phe Phe Ile Met Gly Leu Phe Gly Val Leu
                  65                  70                  75

 att tgc cac ctg ctt aag aag aaa ggc tat cgt tgt aca aca gaa gca      348
 Ile Cys His Leu Leu Lys Lys Lys Gly Tyr Arg Cys Thr Thr Glu Ala
              80                  85                  90

 gag caa gat atc gaa gag gaa aag gtt gaa aag ata gaa ttg aat gac      396
 Glu Gln Asp Ile Glu Glu Glu Lys Val Glu Lys Ile Glu Leu Asn Asp
          95                 100                 105

 agt gtg aat gaa aac agt gac act gtt ggg caa atc gtc cac tac atc      444
 Ser Val Asn Glu Asn Ser Asp Thr Val Gly Gln Ile Val His Tyr Ile
     110                 115                 120

 atg aaa aat gaa gcg aat gct gat gtc tta aag gcg atg gta gca gat      492
 Met Lys Asn Glu Ala Asn Ala Asp Val Leu Lys Ala Met Val Ala Asp
 125                 130                 135                 140

 aac agc ctg tat gat cct gaa agc ccc gtg acc ccc agc aca cca ggg      540
 Asn Ser Leu Tyr Asp Pro Glu Ser Pro Val Thr Pro Ser Thr Pro Gly
                 145                 150                 155

 agc ccg cca gtg agt cct ggg cct ttg tca cca ggg ggg acg cca ggg      588
 Ser Pro Pro Val Ser Pro Gly Pro Leu Ser Pro Gly Gly Thr Pro Gly
             160                 165                 170

 aag cac gtc tgt ggc cat cat ctg cat acg gtg ggc ggt gtt gtc gag      636
 Lys His Val Cys Gly His His Leu His Thr Val Gly Gly Val Val Glu
         175                 180                 185

 agg gat gtg tgt cat cgg tgt agg cac aag cgg tgg cac ttt ata aag      684
 Arg Asp Val Cys His Arg Cys Arg His Lys Arg Trp His Phe Ile Lys
     190                 195                 200

 ccc act aac aag tcc aga gag agc aga cca cgg cgc caa ggc gag gtc      732
 Pro Thr Asn Lys Ser Arg Glu Ser Arg Pro Arg Arg Gln Gly Glu Val
 205                 210                 215                 220

 acg gtc ctt tct gtt ggc aga ttt aga gtt aca aaa gtg gag cac aag      780
 Thr Val Leu Ser Val Gly Arg Phe Arg Val Thr Lys Val Glu His Lys
                 225                 230                 235

 tca aac cag aag gaa cgg aga agc ctg atg tct gtt agt ggg gct gaa      828
 Ser Asn Gln Lys Glu Arg Arg Ser Leu Met Ser Val Ser Gly Ala Glu
             240                 245                 250

 acc gtc aat ggg gag gtg ccg gca aca cct gtg aag aga gaa cgc agt      876
 Thr Val Asn Gly Glu Val Pro Ala Thr Pro Val Lys Arg Glu Arg Ser
         255                 260                 265

 ggc aca gag tag cag tgtcctgaat gacagctcat ctacacagag tgaaactcca      931
 Gly Thr Glu 
     270

 gatatgtgac aagcagcatg ggacagatgc tgacaatcag aacagatgct ggatgtaaac    991

 aactgcacct gcaccccatc tggattgttt tctgttacca cctggaaaag aaagcgtaaa   1051

 agaggacaca ggaacctcac cagggcacgg cccactgcac gcagcagcag gaggggaagg   1111

 agattctgac ggattccttg ccagggcatt tgctcctcaa gagttaaagg atgccggaat   1171

 aagctggcgg atccattgtg tcccatgatt caggccctga ggagcgt                 1218




      <210> 75
      <211> 630
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(630)

      <400> 75
 gcggtggaat tcgtctcctg gcagcag    atg cgc cct gag cac aaa aga aaa      51
                                  Met Arg Pro Glu His Lys Arg Lys
                                    1               5

 atc ctt gtc ctg ggc ttg cca acc agc aga tcc aag ctt tgt ttt gtt       99
 Ile Leu Val Leu Gly Leu Pro Thr Ser Arg Ser Lys Leu Cys Phe Val
      10                  15                  20

 ttg ttt tgt ttt gtt ttg ttt tgt ttt gtt ttg ttt gtt aag ctc ttt      147
 Leu Phe Cys Phe Val Leu Phe Cys Phe Val Leu Phe Val Lys Leu Phe
  25                  30                  35                  40

 cct gga ctc ttt cta cag cat ctg ttt ctt tct ctt aca gac tct ttt      195
 Pro Gly Leu Phe Leu Gln His Leu Phe Leu Ser Leu Thr Asp Ser Phe
                  45                  50                  55

 cat gcc aaa gtc aca cag act cca gga cat ttg gtc aaa gga aaa gga      243
 His Ala Lys Val Thr Gln Thr Pro Gly His Leu Val Lys Gly Lys Gly
              60                  65                  70

 cag aaa aca aag atg gat tgt acc ccc gaa aaa gga cat act ttt gtt      291
 Gln Lys Thr Lys Met Asp Cys Thr Pro Glu Lys Gly His Thr Phe Val
          75                  80                  85

 tat tgg tat caa cag aat cag aat aaa gag ttt atg ctt ttg att tcc      339
 Tyr Trp Tyr Gln Gln Asn Gln Asn Lys Glu Phe Met Leu Leu Ile Ser
      90                  95                 100

 ttt cag aat gaa caa gtt ctt caa gaa acg gag atg cac aag aag cga      387
 Phe Gln Asn Glu Gln Val Leu Gln Glu Thr Glu Met His Lys Lys Arg
 105                 110                 115                 120

 ttc tca tct caa tgc ccc aag aac cca ccc tgc agc ctg gca atc ctg      435
 Phe Ser Ser Gln Cys Pro Lys Asn Pro Pro Cys Ser Leu Ala Ile Leu
                 125                 130                 135

 tcc tcg gaa ccg gga gac acc gca ctg tat ctc tgt gcc acc agt ccg      483
 Ser Ser Glu Pro Gly Asp Thr Ala Leu Tyr Leu Cys Ala Thr Ser Pro
             140                 145                 150

 tcc aca gca ctg aaa tgt cag ttc ctg tta gca cac aaa ctt gcc aca      531
 Ser Thr Ala Leu Lys Cys Gln Phe Leu Leu Ala His Lys Leu Ala Thr
         155                 160                 165

 gac cca gct cag gaa gca ggt gat gta tta ggt tgg aag gga gta aca      579
 Asp Pro Ala Gln Glu Ala Gly Asp Val Leu Gly Trp Lys Gly Val Thr
     170                 175                 180

 gaa aat aac tgg agc cag ctt aag cca cag tgg aat tta aca caa gga      627
 Glu Asn Asn Trp Ser Gln Leu Lys Pro Gln Trp Asn Leu Thr Gln Gly
 185                 190                 195                 200

 taa                                                                  630
 






      <210> 76
      <211> 2884
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2626)..(2772)

      <400> 76
 aggaagttga ccgaggcggc tgccgcagga tcccgagctc cacttcccat ctgctattgt     60

 ttccgattgt tttccggtgg cgagcccggc tccgaaactt acaaagtgtt ggatgtcccc    120

 cgttcgaact gagggactgc agaccgcctc tgggtagctg gatgaagccc accccgtccc    180

 cttctggtac caaagtgctt actcctctcc aaagtgccgt gtctgaactg ccgctgggaa    240

 gaagcggctc ctgagacgcg cccacacctt tcacctgccg cgcgcttccc cctcctcggc    300

 caccttcccg gcggaagcag cgaggaggga gccccctttg gccgtcctcc gtggaaccgg    360

 ttttccgagg ctggcaaaag ccgaggctgg atttggggga ggaatattag actcggagga    420

 gtctgcgcgc ttttctcctc cccgcgcctc ccggtcgccg cgggttcacc gctcagtccc    480

 cgcgctcgct ccgcacccca cccacttcct gtgctcgccc ggggggcgtg tgccgtgcgg    540

 ctgccggagt tcggggaagt tgtggctgtc gagaatgggg gtctgtgggt acctgttcct    600

 gccctggaag tgcctcgtgg tcgtgtctct caggctgctg ttccttgtac ccacaggagt    660

 gcccgtgcgc agcggagatg ccaccttccc caaagctatg gacaacgtga cggtccggca    720

 gggggagagc gccaccctca ggtgcactat tgacaaccgg gtcacccggg tggcctggct    780

 aaaccgcagc accatcctct atgctgggaa tgacaagtgg tgcctggatc ctcgcgtggt    840

 ccttctgagc aacacccaaa cgcagtacag catcgagatc cagaacgtgg atgtgtatga    900

 cgagggccct tacacctgct cggtgcagac agacaaccac ccaaagacct ctagggtcca    960

 cctcattgtg caagtatctc ccaaaattgt agagatttct tcagatatct ccattaatga   1020

 agggaacaat attagcctca cctgcatagc aactggtaga ccagagccta cggttacttg   1080

 gagacacatc tctcccaaag cggttggctt tgtgagtgaa gacgaatact tggaaattca   1140

 gggcatcacc cgggagcagt caggggacta cgagtgcagt gcctccaatg acgtggccgc   1200

 gcccgtggta cggagagtaa aggtcaccgt gaactatcca ccatacattt cagaagccaa   1260

 gggtacaggt gtccccgtgg gacaaaaggg gacactgcag tgtgaagcct cagcagtccc   1320

 ctcagcagaa ttccagtggt acaaggatga caaaagactg attgaaggaa agaaaggggt   1380

 gaaagtggaa aacagacctt tcctctcaaa actcatcttc ttcaatgtct ctgaacatga   1440

 ctatgggaac tacacttgcg tggcctccaa caagctgggc cacaccaatg ccagcatcat   1500

 gctatttggt ccaggcgccg tcagcgaggt gagcaacggc acgtcgagga gggcaggctg   1560

 cgtctggctg ctgcctcttc tggtcttgca cctgcttctc aaattttgat gtgagtgcca   1620

 cttccccacc cgggaaaggc tgccgccacc accaccacca acacaacagc aatggcaaca   1680

 ccgacagcaa ccaatcagat atatacaaat gaaattagaa gaaacacagc ctcatgggac   1740

 agaaatttga gggaggggaa caaagaatac tttgggggga aaagagtttt aaaaaagaaa   1800

 ttgaaaattg ccttgcagat atttaggtac aatggagttt tcttttccca aacgggaaga   1860

 acacagcaca cccggcttgg acccactgca agctgcatcg tgcaacctct ttggtgccag   1920

 tgtgggcaag ggctcagcct ctctgcccac agagtgcccc cacgtggaac attctggagc   1980

 tggccatccc aaattcaatc agtccataga gacgaacaga atgagacctt ccggcccaag   2040

 cgtggcgctt ccggcccaag cgtggcgctg cgggcacttt ggtagactgt gccaccacgg   2100

 cgtgtgttgt gaaacgtgaa ataaaaagag caagaaagaa aaaggaaaca aaataagacc   2160

 gtctgacagc aacaacggtc ccacaaacaa gtcacaaaag ataccgttaa actttttttt   2220

 tttttatcat tttactacat gaacatcatg gataacaagg gattctgatt cattattaat   2280

 ttcattaatt atattttctg atatgagtct agaacttact gcaaaaacaa gacaaaacta   2340

 aaaaaataca actgagaagg gtgaagagaa gtatgtttgt taaacagtaa aaatgaatag   2400

 tatacttctt aactaggttt acaactggtg gaccacacac caggcactaa tcacctggtg   2460

 aggatttggc atatccacca aaaaaatgca tccgatttaa ccaacatctc caccagcgct   2520

 acggactcct cccaattctg acatctcttg cagacaatac tatgctctct acacactgtt   2580

 tagaaatgga aaggtgatct gcactgtatc ttgggtttgt tggct    atg ctt cct    2634
                                                      Met Leu Pro
                                                        1

 ttg atg aca tat att ata cag tat ata tat aca tat att ttt ttt gtt     2682
 Leu Met Thr Tyr Ile Ile Gln Tyr Ile Tyr Thr Tyr Ile Phe Phe Val
       5                  10                  15

 aga gtt cta gcc att tta ttt ctc cgc agg gtc ctt tct cag aca tta     2730
 Arg Val Leu Ala Ile Leu Phe Leu Arg Arg Val Leu Ser Gln Thr Leu
  20                  25                  30                  35

 ctg cat gct gta tat ggc gtt agc tgt gtg ttg atc ttc taa aagatga     2779
 Leu His Ala Val Tyr Gly Val Ser Cys Val Leu Ile Phe 
                  40                  45

 tagagtttac tggtaattgt gtaatcagct cctgcctttt tattttcttg ggttatttac   2839

 atgtcagaga catttataaa aagtgaaagg ataaaaaaaa aaaaa                   2884




      <210> 77
      <211> 520
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (161)..(466)

      <400> 77
 cttcgggcct aaccccccac cctatattca ctcattccaa acctctggcc tccccagcaa     60

 ctctacatcc tcatctccat ctgttccctc tctcgatgct gtgggtgacg ttcggagagg    120

 gaagcccgga ggcctgacct agtccggcgt ggagagagga  atg gaa agc agt gtc     175
                                              Met Glu Ser Ser Val
                                                1               5

 cct ttt gag aag gca aat tta cag ctg gct ttt gta atc cta gct att      223
 Pro Phe Glu Lys Ala Asn Leu Gln Leu Ala Phe Val Ile Leu Ala Ile
                  10                  15                  20

 ttt tgt ttg ttt gct aag tct ttg ata gtc ccc agt gtg gtt tgt ctg      271
 Phe Cys Leu Phe Ala Lys Ser Leu Ile Val Pro Ser Val Val Cys Leu
              25                  30                  35

 cca gtg atc tca gca cca cca gag agc ttg tta gaa atg cgg cat ccc      319
 Pro Val Ile Ser Ala Pro Pro Glu Ser Leu Leu Glu Met Arg His Pro
          40                  45                  50

 aac ccc acc aca gcc ctc cca agt cag ata ctg cca cct cac gag gcc      367
 Asn Pro Thr Thr Ala Leu Pro Ser Gln Ile Leu Pro Pro His Glu Ala
      55                  60                  65

 ccc cag gga tcc aca agt tca tta aag ttt cag gaa tcc aat tct act      415
 Pro Gln Gly Ser Thr Ser Ser Leu Lys Phe Gln Glu Ser Asn Ser Thr
  70                  75                  80                  85

 aca aaa tat aca ttt ata att agg aaa agg ata gtt tct ttt aaa tgg      463
 Thr Lys Tyr Thr Phe Ile Ile Arg Lys Arg Ile Val Ser Phe Lys Trp
                  90                  95                 100

 tag aact tccccaatga gtcagctacc tgtatttctg gcctgtcagg ctagacactg      520
 






      <210> 78
      <211> 1860
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1614)..(1838)

      <400> 78
 tggatcggat attataatac ccacttctta tgatgaaaag gaactgaatg agtgtggaat     60

 ccctaggacc ccgctggaat ataatgggcc ctcggggttt agtttctttc cctcttgccg    120

 gtggtggcta ctgagactgc agtgccccag gagcggtaag agggccacca gcagggaagg    180

 ctgctcctgt cgggctagag gacgaggaca tgggagagct acttgcccca cgttgggggc    240

 tggggcctgt gacatggcac ctcgccttgc tgcagttggt ggcagccaca gagacggcag    300

 cgcagctgaa gtggtaagca agggatcttg tgtgttggaa aaagaattac tttggtgcag    360

 ccgcccaaga ggagcttggg gaggacgctg gcccgcgagg ctcgtcgcag acaacgcggc    420

 ggcgatgtcc gcgagccagg cgagtgccgc ggcggcagcg gcggggcctt gcgcgcggca    480

 gggcggcctg ggcttcggcc tccctccggt tccctggaag cgggcccgcg accagcgcgg    540

 gagcagcagc agaggcggag gctccagcgc gtctctctcc tccccctcag cctgagccgg    600

 gggaagccag gcggcccggg tgtctggagg ggggggggtc cgctgcccga gaatgggaat    660

 tctcttcact agaatatgga gactgttcaa tcaccaggag cacaaagtta tcattgttgg    720

 gctggataat gcagggaaaa ctaccattct ttaccaattt tctatgaatg aagttgtaca    780

 tacatctcct acaataggaa gtaatgtaga agagatagtg attaataata cacgtttcct    840

 aatgtgggat attggtggcc aagaatctct tcgttcttcc tggaacactt actatactaa    900

 cacagagttt gtaatagttg ttgtggacag tacagacaga gagaggattt ctgtaactag    960

 agaagaactc tataaaatgt tagcgcatga ggacctaaga aaagctggat tgctgatttt   1020

 tgctaataaa caagatgtta aagaatgcat gactgtagca gaaatctccc agtttttgaa   1080

 gctaacttct attaaagatc accagtggca tatccaggca tgctgtgctc taactggcga   1140

 gggattgtgc caaggacttg aatggatgat gtcacgactt aagattagat gatctctact   1200

 gacctcttct catagatttt gtataaatga agtgctggac tttacctgaa agctgcaaaa   1260

 attaatggtt tagatatatt tataataaac tgatttaaac tttttctata agaagaaaaa   1320

 ttaagaccac ttatttgaaa acaaagatga agtctcacct tccagtttgc tttctcatta   1380

 gttttttcca aagtaagtta ttgaagctgt gattgacatt tttctcataa tgaatcctct   1440

 caggacattg tgtagcctat ggtaagtaca aagggagagg aagacatttt gaattttaag   1500

 agctttatta tcagtttaac cctccctagt tgaatgttat tttcttcttg ttccattaag   1560

 tcagaataca aatcagcaca gatattcgaa tgtttccaat attttaaaat gta   atg    1616
                                                              Met
                                                                1

 tta ctt atg aaa agt att ttg ctt aag gtt gtg tgt gta ttg tgt ata     1664
 Leu Leu Met Lys Ser Ile Leu Leu Lys Val Val Cys Val Leu Cys Ile
               5                  10                  15

 tac ctc aag ttc aag tta atg gca ttg att tat gtt cca gac aaa aat     1712
 Tyr Leu Lys Phe Lys Leu Met Ala Leu Ile Tyr Val Pro Asp Lys Asn
          20                  25                  30

 aac aca aat aat aat atc ctt cgt tat aac cac aat gag ata agt att     1760
 Asn Thr Asn Asn Asn Ile Leu Arg Tyr Asn His Asn Glu Ile Ser Ile
      35                  40                  45

 ggc att agt gtt cag tgc cat ttt ata ctt tct ctc tgt gtt ctc tgt     1808
 Gly Ile Ser Val Gln Cys His Phe Ile Leu Ser Leu Cys Val Leu Cys
  50                  55                  60                  65

 att gta cta acc aac ctc cca aat cgc tga g ctgcttgttt aaaaaaaaaa     1859
 Ile Val Leu Thr Asn Leu Pro Asn Arg 
                  70

 a                                                                   1860




      <210> 79
      <211> 2885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (737)..(2593)

      <400> 79
 agaactgagc ccttctcggc ccttacctaa agcagccacc ctctttacaa gtgggtgagc     60

 tgggttggct ggcctggcat gaggccaagg ggtaggcttg agcgccagag tcgcccaggt    120

 tagcccacag gattcctttg tgtgccatgg aatgctgaaa gatgggtgac tggggaccct    180

 tcttaaaact ttggcaaagg tgccatcggc agggcttggc ctcatgaagt ctcaggtccg    240

 tgttcccgca gggcgcacat gcttggagag tcctcagcag ggtagccgag gccaggccac    300

 ttctgctgag gatggggcag gctggggtgt gggtgtggcc tggggtggct cagggctgga    360

 actgctgcct gattcctgtg tggggagaag ctcagtggcc gtttgctgcc actgacaagg    420

 atttcacatg cagaagagaa aaggcccccc tccacccccc gcattccctg ccgagtgaga    480

 gccagtgttt gctgcccttg ctgggggcgg gtaggaaacc ctgagcttcc tgatgcggag    540

 tcatgaagca gagtcctcgg gaaggcatct ccccaacctt ccctcatctc tggcggccct    600

 cttgggcctc tgacccagcc cctccccggg ccaggctcac agaagctggc ttctgggact    660

 gtcctgggcc caagtgggca cctgcgccag ccccacctgt gcctgggctg tggccccttc    720

 ctacagggcg ctcacc    atg gcc ccg ccg ctc ctg ctg ctg ctg ctg gcc     769
                      Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala
                        1               5                  10

 agt gga gcg gcc gcc tgc ccg ctg ccc tgc gtc tgc cag aac ctg tcc      817
 Ser Gly Ala Ala Ala Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser
              15                  20                  25

 gag tcg ctc agc acc ctc tgt gcc cac cga ggc ctg ctg ttt gtg ccg      865
 Glu Ser Leu Ser Thr Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro
          30                  35                  40

 ccc aac gtg gac cgg cgc aca gtg gag ctg cgg ctg gct gac aac ttc      913
 Pro Asn Val Asp Arg Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe
      45                  50                  55

 atc cag gcc ctg ggg ccc cct gac ttc cgc aac atg acg gga ctg gtg      961
 Ile Gln Ala Leu Gly Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val
  60                  65                  70                  75

 gac ctg aca ctg tct cgc aat gcc atc acc cgc att ggg gcc cgc gcc     1009
 Asp Leu Thr Leu Ser Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala
                  80                  85                  90

 ttt ggg gac ctc gag agc ctg cgt tcc ctc cac ctt gac ggc aac agg     1057
 Phe Gly Asp Leu Glu Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg
              95                 100                 105

 ctg gtg gag ctg ggc acc ggg agc ctc cgg ggc ccc gtc aat ctg cag     1105
 Leu Val Glu Leu Gly Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln
         110                 115                 120

 cac ctc atc ctc agc ggc aac cag ctg ggc cgc atc gcg ccg gga gcc     1153
 His Leu Ile Leu Ser Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala
     125                 130                 135

 ttc gac gac ttc cta gag agc ctg gag gac ctg gac ctg tcc tac aac     1201
 Phe Asp Asp Phe Leu Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn
 140                 145                 150                 155

 aac ctc cgg cag gtg ccc tgg gcc ggc atc ggc gcc atg cct gcc ctg     1249
 Asn Leu Arg Gln Val Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu
                 160                 165                 170

 cac acc ctc aac ctg gac cat aac ctt att gac gca ctg ccc cca ggc     1297
 His Thr Leu Asn Leu Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly
             175                 180                 185

 gcc ttc gcc cag ctc ggt cag ctc tcc cgc ctg gac ctc acc tcc aac     1345
 Ala Phe Ala Gln Leu Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn
         190                 195                 200

 cgc ctg gcc acg ctg gct ccg gac ccg ctt ttc tct ccg gga acc ctg     1393
 Arg Leu Ala Thr Leu Ala Pro Asp Pro Leu Phe Ser Pro Gly Thr Leu
     205                 210                 215

 cac tgc aac tgt gag ctg ctg tgg ctg cgg cgg ctg gcg cgg ccg gac     1441
 His Cys Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp
 220                 225                 230                 235

 gac ctg gaa acg tgc gcc tcc ccg ccc ggc ctg gcc ggc cgc tac ttc     1489
 Asp Leu Glu Thr Cys Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe
                 240                 245                 250

 tgg gca gtg ccc gag ggc gag ttc tcc tgt gag ccg ccc ctc att gcc     1537
 Trp Ala Val Pro Glu Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala
             255                 260                 265

 cgc cac acg cag cgc ctc tgg gtg ctg gaa ggc cag cgg gcc acg ctg     1585
 Arg His Thr Gln Arg Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu
         270                 275                 280

 cgg tgc cgg gcc ctg ggt gac ccc gcg cct acc atg cac tgg gtc ggt     1633
 Arg Cys Arg Ala Leu Gly Asp Pro Ala Pro Thr Met His Trp Val Gly
     285                 290                 295

 cct gac gac cgg ttg gtt ggc aac tcc tcc cga gcc cgg gct ttc ccc     1681
 Pro Asp Asp Arg Leu Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro
 300                 305                 310                 315

 aac ggg acc tta gag att ggg gtg acc ggc gct ggg gac gct ggg ggc     1729
 Asn Gly Thr Leu Glu Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly
                 320                 325                 330

 tac acc tgc atc gcc acc aac cct gct ggt gag gcc aca gcc cga gta     1777
 Tyr Thr Cys Ile Ala Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val
             335                 340                 345

 gaa ctg cgg gtg ctg gcc ttg ccc cat ggt ggg aac agc agt gcc gag     1825
 Glu Leu Arg Val Leu Ala Leu Pro His Gly Gly Asn Ser Ser Ala Glu
         350                 355                 360

 ggg ggc cgc ccc ggg ccc tcg gac atc gcc gcc tcc gct cgc act gct     1873
 Gly Gly Arg Pro Gly Pro Ser Asp Ile Ala Ala Ser Ala Arg Thr Ala
     365                 370                 375

 gcc gag ggt gag ggg acg ctg gag tct gag cca gcc gtg cag gtg acg     1921
 Ala Glu Gly Glu Gly Thr Leu Glu Ser Glu Pro Ala Val Gln Val Thr
 380                 385                 390                 395

 gag gtg acc gcc acc tca ggg ctg gtg agc tgg ggt ccc ggg cgg cca     1969
 Glu Val Thr Ala Thr Ser Gly Leu Val Ser Trp Gly Pro Gly Arg Pro
                 400                 405                 410

 gcc gac cca gtg tgg atg ttc caa atc cag tac aac agc agc gaa gat     2017
 Ala Asp Pro Val Trp Met Phe Gln Ile Gln Tyr Asn Ser Ser Glu Asp
             415                 420                 425

 gag acc ctc atc tac cgg att gtc cca gcc tcc agc cac cac ttc ctg     2065
 Glu Thr Leu Ile Tyr Arg Ile Val Pro Ala Ser Ser His His Phe Leu
         430                 435                 440

 ctg aag cac ctc gtc ccc ggc gct gac tat gac ctc tgc ctg ctg gcc     2113
 Leu Lys His Leu Val Pro Gly Ala Asp Tyr Asp Leu Cys Leu Leu Ala
     445                 450                 455

 ttg tca ccg gcc gct ggg ccc tct gac ctc acg gcc acc agg ctg ctg     2161
 Leu Ser Pro Ala Ala Gly Pro Ser Asp Leu Thr Ala Thr Arg Leu Leu
 460                 465                 470                 475

 ggc tgt gcc cat ttc tcc acg ctg ccg gcc tcg ccc ctg tgc cac gcc     2209
 Gly Cys Ala His Phe Ser Thr Leu Pro Ala Ser Pro Leu Cys His Ala
                 480                 485                 490

 ctg cag gcc cac gtg ctg ggc ggg acc ctg acc gtg gcc gtg ggg ggt     2257
 Leu Gln Ala His Val Leu Gly Gly Thr Leu Thr Val Ala Val Gly Gly
             495                 500                 505

 gtg ctg gtg gct gcc tta ctg gtc ttc act gtg gcc ttg ctg gtt cgg     2305
 Val Leu Val Ala Ala Leu Leu Val Phe Thr Val Ala Leu Leu Val Arg
         510                 515                 520

 ggc cgg ggg gcc gga aat ggc cgc ctc ccc ctc aag ctc agc cac gtc     2353
 Gly Arg Gly Ala Gly Asn Gly Arg Leu Pro Leu Lys Leu Ser His Val
     525                 530                 535

 cag tcc cag acc aat gga ggc ccc agc ccc aca ccc aag gcc cac ccg     2401
 Gln Ser Gln Thr Asn Gly Gly Pro Ser Pro Thr Pro Lys Ala His Pro
 540                 545                 550                 555

 ccg cgg agc ccc ccg ccc cgg ccg cag cgc agc tgc tct ctg gac ctg     2449
 Pro Arg Ser Pro Pro Pro Arg Pro Gln Arg Ser Cys Ser Leu Asp Leu
                 560                 565                 570

 gga gat gcc ggg tgc tac ggt tat gcc agg cgc ctg gga gga gct tgg     2497
 Gly Asp Ala Gly Cys Tyr Gly Tyr Ala Arg Arg Leu Gly Gly Ala Trp
             575                 580                 585

 gcc cga cgg agc cac tct gtg cat ggg ggg ctg ctc ggg gca ggg tgc     2545
 Ala Arg Arg Ser His Ser Val His Gly Gly Leu Leu Gly Ala Gly Cys
         590                 595                 600

 cgg ggg gta gga ggc agc gcc gag cgg ctg gaa gag agt gtg gtg tga     2593
 Arg Gly Val Gly Gly Ser Ala Glu Arg Leu Glu Glu Ser Val Val 
     605                 610                 615

 tggacgggca gcttcctgtg tgctccaagg gatgagcctc gtggggcaga gggcccgggg   2653

 ccgccgcctg gcctgggagt ccctccctgg tttttattct cagtacctca ggctcccctg   2713

 tgtacttgga ggggcaggga gccctttcct cggttctggc ctccagacca gggtaagggc   2773

 aggcccctcc aacaggtgct cacagccacc gaggcagggg ctgcagccac ccactgggag   2833

 tcttgttttt atttataata aaattgttgg ggacacctca aaaaaaaaaa aa           2885




      <210> 80
      <211> 1387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(1144)

      <400> 80
 aagatggcgg cgcggggccg cgcccgcgct cccaggctct cctcccccag ccttcctccg     60

 gctggcagca cgactcgcgt agccgtgcgc cgattgcctc tcggcctggg ca    atg     115
                                                              Met
                                                                1

 gtc ccg gct gcc ggt cga cga ccg ccc cgc gtc atg cgg ctc ctc ggc      163
 Val Pro Ala Ala Gly Arg Arg Pro Pro Arg Val Met Arg Leu Leu Gly
               5                  10                  15

 tgg tgg caa gta ttg ctg tgg gtg ctg gga ctt ccc gtc cgc ggc gtg      211
 Trp Trp Gln Val Leu Leu Trp Val Leu Gly Leu Pro Val Arg Gly Val
          20                  25                  30

 gag gtt gca gag gaa agt ggt cgc tta tgg tca gag gag ctc ctg cat      259
 Glu Val Ala Glu Glu Ser Gly Arg Leu Trp Ser Glu Glu Leu Leu His
      35                  40                  45

 gac ccg atg ggc cgg gac agg gca gca gaa gag gcc aat gcg gtg ctg      307
 Asp Pro Met Gly Arg Asp Arg Ala Ala Glu Glu Ala Asn Ala Val Leu
  50                  55                  60                  65

 ggg ctg gac acc caa ggc gat cac atg gtg atg ctg tct gtg att cct      355
 Gly Leu Asp Thr Gln Gly Asp His Met Val Met Leu Ser Val Ile Pro
                  70                  75                  80

 ggg gaa gct gag gac aag gtg agt tca gag cct agc ggc gtc acc tgt      403
 Gly Glu Ala Glu Asp Lys Val Ser Ser Glu Pro Ser Gly Val Thr Cys
              85                  90                  95

 ggt gct gga gga gcg gag gac tca agg tgc aac gtc cga gag agc ctt      451
 Gly Ala Gly Gly Ala Glu Asp Ser Arg Cys Asn Val Arg Glu Ser Leu
         100                 105                 110

 ttc tct ctg gat ggc gct gga gca cac ttc cct gac aga gag gag gag      499
 Phe Ser Leu Asp Gly Ala Gly Ala His Phe Pro Asp Arg Glu Glu Glu
     115                 120                 125

 tat tac aca gag cca gaa gtg gcg gaa tct gac gca gcc ccg aca gag      547
 Tyr Tyr Thr Glu Pro Glu Val Ala Glu Ser Asp Ala Ala Pro Thr Glu
 130                 135                 140                 145

 gac tcc aat aac act gaa agt ctg aaa tcc cca aag gtg aac tgt gag      595
 Asp Ser Asn Asn Thr Glu Ser Leu Lys Ser Pro Lys Val Asn Cys Glu
                 150                 155                 160

 gag aga aac att aca gga tta gaa aat ttc act ctg aaa att tta aat      643
 Glu Arg Asn Ile Thr Gly Leu Glu Asn Phe Thr Leu Lys Ile Leu Asn
             165                 170                 175

 atg tca cag gac ctt atg gat ttt ctg aac cca aac ggt agt gac tgt      691
 Met Ser Gln Asp Leu Met Asp Phe Leu Asn Pro Asn Gly Ser Asp Cys
         180                 185                 190

 act cta gtc ctg ttt tac acc ccg tgg tgc cgc ttt tct gcc agt ttg      739
 Thr Leu Val Leu Phe Tyr Thr Pro Trp Cys Arg Phe Ser Ala Ser Leu
     195                 200                 205

 gcc cct cac ttt aac tct ctg ccc cgg gca ttt cca gct ctt cac ttt      787
 Ala Pro His Phe Asn Ser Leu Pro Arg Ala Phe Pro Ala Leu His Phe
 210                 215                 220                 225

 ttg gca ctg gat gca tct cag cac agc agc ctt tct acc agg ttt ggc      835
 Leu Ala Leu Asp Ala Ser Gln His Ser Ser Leu Ser Thr Arg Phe Gly
                 230                 235                 240

 acc gta gct gtt cct aat att tta tta ttt caa gga gct aaa cca atg      883
 Thr Val Ala Val Pro Asn Ile Leu Leu Phe Gln Gly Ala Lys Pro Met
             245                 250                 255

 gcc aga ttt aat cat aca gat cga aca ctg gaa aca ctg aaa atc ttc      931
 Ala Arg Phe Asn His Thr Asp Arg Thr Leu Glu Thr Leu Lys Ile Phe
         260                 265                 270

 att ttt aat cag aca ggt ata gaa gcc aag aag aat gtg gtg gta act      979
 Ile Phe Asn Gln Thr Gly Ile Glu Ala Lys Lys Asn Val Val Val Thr
     275                 280                 285

 caa gcc gac caa ata ggc cct ctt ccc agc act ttg ata aaa agt gtg     1027
 Gln Ala Asp Gln Ile Gly Pro Leu Pro Ser Thr Leu Ile Lys Ser Val
 290                 295                 300                 305

 gac tgg ttg ctt gta ttt tcc tta ttc ttt tta att agt ttt att atg     1075
 Asp Trp Leu Leu Val Phe Ser Leu Phe Phe Leu Ile Ser Phe Ile Met
                 310                 315                 320

 tat gct acc att cga act gag agt att cgg tgg cta att cca gga caa     1123
 Tyr Ala Thr Ile Arg Thr Glu Ser Ile Arg Trp Leu Ile Pro Gly Gln
             325                 330                 335

 gag cag gaa cat gtg gag tag tg atggtctgaa agaagttgga aagaggaact     1176
 Glu Gln Glu His Val Glu 
         340

 tcaatccttc gtttcagaaa ttagtgctac agtttcatac attttctcca gtgacgtgtt   1236

 gacttgaaac ttcaggcaga ttaaaagaat catttgttga acaactgaat gtataaaaaa   1296

 attataaact ggtgttttaa ctagtattgc aataagcaaa tgcaaaaata ttcaatagat   1356

 gcactattct tgtttttact gcaaaaaaaa a                                  1387




      <210> 81
      <211> 3311
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(2916)

      <220>
      <221> misc_feature
      <222> (1)...(3311)
      <223> n = a,t,c or g

      <400> 81
 tggctgaggg cgtgtgagcg ccgagcgcta agggccgccg ccacc    atg cca ggg      54
                                                      Met Pro Gly
                                                        1

 ggc gca ggc gcc gcc agg ctc tgc ttg ctg gcg ttt gcc ctg cag ccc      102
 Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala Leu Gln Pro
       5                  10                  15

 ctc cgg ccg cgg gcg gcg cgg gag cct gga tgg aca agt aaa gga agt      150
 Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Ser Lys Gly Ser
  20                  25                  30                  35

 gag gaa ggc agc ccc aag ctg cag cat gaa ctt atc ata cct cag tgg      198
 Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile Pro Gln Trp
                  40                  45                  50

 aag act tca gaa agc ccc gtg aga gaa aag cat cca ctc aaa gct gag      246
 Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu Lys Ala Glu
              55                  60                  65

 ctc agg gta atg gct gag ggg cga gaa ctg atc ctg gac ctg gag aag      294
 Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp Leu Glu Lys
          70                  75                  80

 aat gag caa ctt ttt gct cct tcc tac aca gaa acc cat tat act tca      342
 Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His Tyr Thr Ser
      85                  90                  95

 agt ggt aac cct caa acc acc aca cgg aaa ttg gag gat cac tgc ttt      390
 Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp His Cys Phe
 100                 105                 110                 115

 tac cac ggc acg gtg agg gag aca gaa ctg tcc agc gtc acg ctc agc      438
 Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val Thr Leu Ser
                 120                 125                 130

 act tgc cga gga att aga gga ctg att acg gtg agc agc aac ctc agc      486
 Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser Asn Leu Ser
             135                 140                 145

 tac gtc atc gag ccc ctc cct gac agc aag ggc caa cac ctt att tac      534
 Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His Leu Ile Tyr
         150                 155                 160

 aga tct gaa cat ctc aag ccg ccc ccg gga aac tgt ggg ttc gag cac      582
 Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly Phe Glu His
     165                 170                 175

 tcc aag ccc acc acc agg gac tgg gct ctt cag ttt aca caa cag acc      630
 Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr Gln Gln Thr
 180                 185                 190                 195

 aag aag cga cct cgc agg atg aaa agg gaa gat tta aac tcc atg aag      678
 Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn Ser Met Lys
                 200                 205                 210

 tat gtg gag ctt tac ctc gtg gct gat tat tta gag ttt cag aag aat      726
 Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe Gln Lys Asn
             215                 220                 225

 cga cga gac cag gac gcc acc aaa cac aag ctc ata gag atc gcc aac      774
 Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu Ile Ala Asn
         230                 235                 240

 tat gtt gat aag ttt tac cga tcc ttg aac atc cgg att gct ctc gtg      822
 Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile Ala Leu Val
     245                 250                 255

 ggc ttg gaa gtg tgg acc cac ggg aac atg tgt gaa gtt tca gag aat      870
 Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val Ser Glu Asn
 260                 265                 270                 275

 cca tat tct acc ctc tgg tcc ttt ctc agt tgg agg cgc aag ctg ctt      918
 Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg Lys Leu Leu
                 280                 285                 290

 gcc cag aag tac cat gac aac gcc caa tta atc acg ggc atg tcc ttc      966
 Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly Met Ser Phe
             295                 300                 305

 cac ggc acc acc atc ggc ctg gcc ccc ctc atg gcc atg tgc tct gtg     1014
 His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met Cys Ser Val
         310                 315                 320

 tac cag tct gga gga gtc aac atg gac cac tcc gag aat gcc att ggc     1062
 Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn Ala Ile Gly
     325                 330                 335

 gtg gct gcc acc atg gcc cac gag atg ggc cac aac ttt ggc atg acc     1110
 Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe Gly Met Thr
 340                 345                 350                 355

 cat gat tct gca gat tgc tgc tcg gcc agt gcg gct gat ggt ggg tgc     1158
 His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp Gly Gly Cys
                 360                 365                 370

 atc atg gca gct gcc act ggg cac ccc ttt ccc aaa gtg ttc aat gga     1206
 Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val Phe Asn Gly
             375                 380                 385

 tgc aac agg agg gag ctg gac agg tat ctg cag tca ggt ggt gga atg     1254
 Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly Gly Gly Met
         390                 395                 400

 tgt ctc tcc aac atg cca gac acc agg atg ttg tat gga ggc cgg agg     1302
 Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly Gly Arg Arg
     405                 410                 415

 tgt ggg aac ggg tat ctg gaa gat ggg gaa gag tgt gac tgt gga gaa     1350
 Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp Cys Gly Glu
 420                 425                 430                 435

 gaa gag gaa tgt aac aac ccc tgc tgc aat gcc tct aat tgt acc ctg     1398
 Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn Cys Thr Leu
                 440                 445                 450

 agg ccg ggg gcg gag tgt gct cac ggc tcc tgc tgc cac cag tgt aag     1446
 Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His Gln Cys Lys
             455                 460                 465

 ctg ttg gct cct ggg acc ctg tgc cgc gag cag gcc agg cag tgt gac     1494
 Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg Gln Cys Asp
         470                 475                 480

 ctc ccg gag ttc tgt acg ggc aag tct ccc cac tgc cct acc aac ttc     1542
 Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro Thr Asn Phe
     485                 490                 495

 tac cag atg gat ggt acc ccc tgt gag ggc ggc cag gcc tac tgc tac     1590
 Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala Tyr Cys Tyr
 500                 505                 510                 515

 aac ggc atg tgc ctc acc tac cag gag cag tgc cag cag ctg tgg gga     1638
 Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln Leu Trp Gly
                 520                 525                 530

 ccc gga gcc cga cct gcc cct gac ctc tgc ttc gag aag gtg aat gtg     1686
 Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys Val Asn Val
             535                 540                 545

 gca gga gac acc ttt gga aac tgt gga aag gac atg aat ggt gaa cac     1734
 Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn Gly Glu His
         550                 555                 560

 agg aag tgc aac atg aga gat gcg aag tgt ggg aag atc cag tgt cag     1782
 Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile Gln Cys Gln
     565                 570                 575

 agc tct gag gcc cgg ccc ctg gag tcc aac gcg gtg ccc att gac acc     1830
 Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro Ile Asp Thr
 580                 585                 590                 595

 act atc atc atg aat ggg agg cag atc cag tgc cgg ggc acc cac gtc     1878
 Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly Thr His Val
                 600                 605                 610

 tac cga ggt cct gag gag gag ggt gac atg ctg gac cca ggg ctg gtg     1926
 Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro Gly Leu Val
             615                 620                 625

 atg act gga acc aag tgt ggc tac aac cat att tgc ttt gag ggg cag     1974
 Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe Glu Gly Gln
         630                 635                 640

 tgc agg aac acc tcc ttc ttt gaa act gaa ggc tgt ggg aag aag tgc     2022
 Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys Lys Cys
     645                 650                 655

 aat ggc cat ggg gtc tgt aac aac aac cag aac tgc cac tgc ctg ccg     2070
 Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His Cys Leu Pro
 660                 665                 670                 675

 ggc tgg gcc ccg ccc ttc tgc aac aca ccg ggc cac ggg ggc agt atc     2118
 Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly Gly Ser Ile
                 680                 685                 690

 gac agt ggg cct atg ccc cct gag agt gtg ggt cct gtg gta gct gga     2166
 Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val Val Ala Gly
             695                 700                 705

 gtg ttg gtg gcc atc ttg gtg ctg gcg gtc ctc atg ctg atg tac tac     2214
 Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu Met Tyr Tyr
         710                 715                 720

 tgc tgc aga cag aac aac aaa cta ggc caa ctc aag ccc tca gct ctc     2262
 Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser Ala Leu
     725                 730                 735

 cct tcc aag ctg agg caa cag ttc agt tgt ccc ttc agg gtt tct cag     2310
 Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg Val Ser Gln
 740                 745                 750                 755

 aac agc ggg act ggt cat gcc aac cca act ttc aag ctg cag acg ccc     2358
 Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu Gln Thr Pro
                 760                 765                 770

 cag ggc aag cga aag gtg atc aac act ccg gaa atc ctg cgg aag ccc     2406
 Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu Arg Lys Pro
             775                 780                 785

 tcc cag cct cct ccc cgg ccc cct cca gat tat ctg cgt ggt ggg tcc     2454
 Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly Gly Ser
         790                 795                 800

 cca cct gca cca ctg cca gct cac ctg agc agg gct gct agg aac tcc     2502
 Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala Arg Asn Ser
     805                 810                 815

 cca ggg ccc ggg tct caa ata gag agg acg gag tcg tcc agg agg cct     2550
 Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg Arg Pro
 820                 825                 830                 835

 cct cca agc cgg cca att ccc ccc gca cca aat tgc atc gtt tcc cag     2598
 Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile Val Ser Gln
                 840                 845                 850

 gac ttc tcc agg cct cgg ccg ccc cag aag gca ctc ccg gca aac cca     2646
 Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro Ala Asn Pro
             855                 860                 865

 gtg cca ggc cgc agg agc ctc ccc agg cca gga ggt gca tcc cca ctg     2694
 Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala Ser Pro Leu
         870                 875                 880

 cgg ccc cct ggt gct ggc cct cag cag tcc cgg cct ctg gca gca ctt     2742
 Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu Ala Ala Leu
     885                 890                 895

 gcc cca aag gtg agt cca cgg gaa gcc ctc aag gtg aaa gct ggt acc     2790
 Ala Pro Lys Val Ser Pro Arg Glu Ala Leu Lys Val Lys Ala Gly Thr
 900                 905                 910                 915

 aga ggg ctc cag ggg ggc agg tgt aga gtt gag aaa aca aag caa ttc     2838
 Arg Gly Leu Gln Gly Gly Arg Cys Arg Val Glu Lys Thr Lys Gln Phe
                 920                 925                 930

 atg ctt ctt gtg gtc tgg act gaa ctt cca gaa caa aag cca agg gca     2886
 Met Leu Leu Val Val Trp Thr Glu Leu Pro Glu Gln Lys Pro Arg Ala
             935                 940                 945

 aaa cat tca tgt ttc ttg gtg ccc gct tga c tgtggagttt tggcttcatg     2937
 Lys His Ser Cys Phe Leu Val Pro Ala 
         950                 955

 tgaaaggtga ttcttagaat cctgagctgt ggtggcttca gtcctgcccc tgcacctgac   2997

 ctggggaggg accctgagca agtccctctt gagtctgttt cctcatttgt acagaggcta   3057

 tgatgagcag tagtaccagc cccatcaggt tgttgtgaag agcaaggaag tgcattagta   3117

 gaaccacctg gcctgcggga ggctgtgtac acttggcccc ttctcgtact tcttctgtgt   3177

 ggctgacagt ctcagtttgc cagtcttgca atcangtcag aaagggatna gtgaanaanc   3237

 tggcttgaca tgctgtattc cacgaggcat tgagaaaact atggactgng ctgctgcctt   3297

 aacagggaag ggaa                                                     3311




      <210> 82
      <211> 1330
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(1280)

      <400> 82
 ggatgctgaa agcgtgttgg ccaaatctga acgatgaaag ccaattacaa actagaaaat     60

 gaaaacagac cccagatgca aggagatgag acagttagat ttacttcctc ttttctaatc    120

 tgagaggttt c atg ttg aag aaa atc agt gtt ggg gtt gca gga gac cta     170
              Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu
                1               5                  10

 aac aca gtc acc atg aag ctg ggc tgt gtc ctc atg gcc tgg gcc ctc      218
 Asn Thr Val Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu
      15                  20                  25

 tac ctt tcc ctt ggt gtg ctc tgg gtg gcc cag atg cta ctg gca gct      266
 Tyr Leu Ser Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala
  30                  35                  40                  45

 gga tgt cat gcc gct gcc agt ttt gag acg ctg cag tgt gag gga cct      314
 Gly Cys His Ala Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro
                  50                  55                  60

 gtc tgc act gag gag agc agc tgc cac acg gag gat gac ttg act gat      362
 Val Cys Thr Glu Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp
              65                  70                  75

 gca agg gaa gct ggc ttc cag gtc aag gcc tac act ttc agt gaa ccc      410
 Ala Arg Glu Ala Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro
          80                  85                  90

 ttc cac ctg att gtg tcc tat gac tgg ctg atc ctc caa ggt cca gcc      458
 Phe His Leu Ile Val Ser Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala
      95                 100                 105

 aag cca gtt ttt gaa ggg gac ctg ctg gtt ctg cgc tgc cag gcc tgg      506
 Lys Pro Val Phe Glu Gly Asp Leu Leu Val Leu Arg Cys Gln Ala Trp
 110                 115                 120                 125

 caa gac tgg cca ctg act cag gtg acc ttc tac cga gat ggc tca gct      554
 Gln Asp Trp Pro Leu Thr Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala
                 130                 135                 140

 ctg ggt ccc ccc ggg cct aac agg gaa ttc tcc atc acc gtg gta caa      602
 Leu Gly Pro Pro Gly Pro Asn Arg Glu Phe Ser Ile Thr Val Val Gln
             145                 150                 155

 aag gca gac agc ggg cac tac cac tgc agt ggc atc ttc cag agc cct      650
 Lys Ala Asp Ser Gly His Tyr His Cys Ser Gly Ile Phe Gln Ser Pro
         160                 165                 170

 ggt cct ggg atc cca gaa aca gca tct gtt gtg gct atc aca gtc caa      698
 Gly Pro Gly Ile Pro Glu Thr Ala Ser Val Val Ala Ile Thr Val Gln
     175                 180                 185

 gaa ctg ttt cca gcg cca att ctc aga gct gta ccc tca gct gaa ccc      746
 Glu Leu Phe Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro
 190                 195                 200                 205

 caa gca gga agc ccc atg acc ctg agt tgt cag aca aag ttg ccc ctg      794
 Gln Ala Gly Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu
                 210                 215                 220

 cag agg tca gct gcc cgc ctc ctc ttc tcc ttc tac aag gat gga agg      842
 Gln Arg Ser Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg
             225                 230                 235

 ata gtg caa agc agg ggg ctc tcc tca gaa ttc cag atc ccc aca gct      890
 Ile Val Gln Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala
         240                 245                 250

 tca gaa gat cac tcc ggg tca tac tgg tgt gag gca gcc act gag gac      938
 Ser Glu Asp His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp
     255                 260                 265

 aac caa gtt tgg aaa cag agc ccc cag cta gag atc aga gtg cag ggt      986
 Asn Gln Val Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly
 270                 275                 280                 285

 gct tcc agc tct gct gca cct ccc aca ttg aat cca gct cct cag aaa     1034
 Ala Ser Ser Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys
                 290                 295                 300

 tca gct gct cca gga act gct cct gag gag gcc cct ggg cct ctg cct     1082
 Ser Ala Ala Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro
             305                 310                 315

 ccg ccg cca acc cca tct tct gag gat cca ggc ttt tct tct cct ctg     1130
 Pro Pro Pro Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu
         320                 325                 330

 ggg atg cca gat cct cat ctg tat cac cag atg ggc ctt ctt ctc aaa     1178
 Gly Met Pro Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys
     335                 340                 345

 cac atg cag gat gtg aga gtc ctc ctc ggt cac ctg ctc atg gag ttg     1226
 His Met Gln Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu
 350                 355                 360                 365

 agg gaa tta tct ggc cac cgg aag cct ggg acc aca aag gct act gct     1274
 Arg Glu Leu Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala
                 370                 375                 380

 gaa tag aagtaaacag ttcatccatg atctcactta accaccccaa taaatctgat      1330
 Glu 






      <210> 83
      <211> 1438
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(1262)

      <400> 83
 ggatgctgaa agcgtgttgg ccaaatctga acgatgaaag ccaattacaa actagaaaat     60

 gaaaacagac cccagatgca aggagatgag acagttagat ttacttcctc ttttctaatc    120

 tgagaggttt c atg ttg aag aaa atc agt gtt ggg gtt gca gga gac cta     170
              Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu
                1               5                  10

 aac aca gtc acc atg aag ctg ggc tgt gtc ctc atg gcc tgg gcc ctc      218
 Asn Thr Val Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu
      15                  20                  25

 tac ctt tcc ctt ggt gtg ctc tgg gtg gcc cag atg cta ctg gct gcc      266
 Tyr Leu Ser Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala
  30                  35                  40                  45

 agt ttt gag acg ctg cag tgt gag gga cct gtc tgc act gag gag agc      314
 Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser
                  50                  55                  60

 agc tgc cac acg gag gat gac ttg act gat gca agg gaa gct ggc ttc      362
 Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe
              65                  70                  75

 cag gtc aag gcc tac act ttc agt gaa ccc ttc cac ctg att gtg tcc      410
 Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser
          80                  85                  90

 tat gac tgg ctg atc ctc caa ggt cca gcc aag cca gtt ttt gaa ggg      458
 Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala Lys Pro Val Phe Glu Gly
      95                 100                 105

 gac ctg ctg gtt ctg cgc tgc cag gcc tgg caa gac tgg cca ctg act      506
 Asp Leu Leu Val Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro Leu Thr
 110                 115                 120                 125

 cag gtg acc ttc tac cga gat ggc tca gct ctg ggt ccc ccc ggg cct      554
 Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro Gly Pro
                 130                 135                 140

 aac agg gaa ttc tcc atc acc gtg gta caa aag gca gac agc ggg cac      602
 Asn Arg Glu Phe Ser Ile Thr Val Val Gln Lys Ala Asp Ser Gly His
             145                 150                 155

 tac cac tgc agt ggc atc ttc cag agc cct ggt cct ggg atc cca gaa      650
 Tyr His Cys Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly Ile Pro Glu
         160                 165                 170

 aca gca tct gtt gtg gct atc aca gtc caa gaa ctg ttt cca gcg cca      698
 Thr Ala Ser Val Val Ala Ile Thr Val Gln Glu Leu Phe Pro Ala Pro
     175                 180                 185

 att ctc aga gct gta ccc tca gct gaa ccc caa gca gga agc ccc atg      746
 Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala Gly Ser Pro Met
 190                 195                 200                 205

 acc ctg agt tgt cag aca aag ttg ccc ctg cag agg tca gct gcc cgc      794
 Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser Ala Ala Arg
                 210                 215                 220

 ctc ctc ttc tcc ttc tac aag gat gga agg ata gtg caa agc agg ggg      842
 Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln Ser Arg Gly
             225                 230                 235

 ctc tcc tca gaa ttc cag atc ccc aca gct tca gaa gat cac tcc ggg      890
 Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp His Ser Gly
         240                 245                 250

 tca tac tgg tgt gag gca gcc act gag gac aac caa gtt tgg aaa cag      938
 Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln Val Trp Lys Gln
     255                 260                 265

 agc ccc cag cta gag atc aga gtg cag ggt gct tcc agc tct gct gca      986
 Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser Ser Ser Ala Ala
 270                 275                 280                 285

 cct ccc aca ttg aat cca gct cct cag aaa tca gct gct cca gga act     1034
 Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro Gly Thr
                 290                 295                 300

 gct cct gag gag gcc cct ggg cct ctg cct ccg ccg cca acc cca tct     1082
 Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr Pro Ser
             305                 310                 315

 tct gag gat cca ggc ttt tct tct cct ctg ggg atg cca gat cct cat     1130
 Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp Pro His
         320                 325                 330

 ctg tat cac cag atg ggc ctt ctt ctc aaa cac atg cag gat gtg aga     1178
 Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln Asp Val Arg
     335                 340                 345

 gtc ctc ctc ggt cac ctg ctc atg gag ttg agg gaa tta tct ggc cac     1226
 Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser Gly His
 350                 355                 360                 365

 cgg aag cct ggg acc aca aag gct act gct gaa tag aagt aaacagttca     1276
 Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu 
                 370                 375

 tccatgatct cacttaacca ccccaataaa tctgattctt tattttctct tcctgtcctg   1336

 cacatatgca taagtacttt tacaagttgt cccagtgttt tgttagaata atgtagttag   1396

 gtgagtgtaa ataaatttat ataaagtgag aaaaaaaaaa aa                      1438




      <210> 84
      <211> 1286
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (680)..(847)

      <400> 84
 aaggtaccat acacttgtta aaaattgctg tggatggaag agggccattg agcttacctc     60

 cctatatggg agagagcaaa ggtgcggcac cctttacact ctggccatga cggctggcag    120

 ggtcagggta gtatctgggc ctgcttcccg gcaagccgag ctagggtgaa aactgggggc    180

 gcaccacgat gtgacacatg aaaagcagaa gatgagactc tgttcattca cttttcctag    240

 gcccatcctg tggtcatctt tccccctccc atcatacctc ctccttcctg gagcctctgc    300

 cggcttggct gtaatggtgg cacttacctg gatatttcag tgggaggatg aaaggcgaga    360

 ctcaccctac gcggtgggac agatggggag aggaaaaagg cagagatggc caggagaggg    420

 gtgcaggaca aaccagagag gttgggtcag gggaaaaggg tggggagaaa gaggggtgca    480

 ggccctgcag gccggttagc cagcagctgc ggcctccccg ggcccttggc atccaacttc    540

 gcagacaggg taccagcctc ctggtgtgta tcataggatt tgttcacata gtgttatgca    600

 tgatcttcgt aaggttaaga agccgtggtg gtgcaccatg acatccaacc cgtatatata    660

 aagataaata tatatatat atg tat gta aat tat agc act gag ggc cct gct     712
                      Met Tyr Val Asn Tyr Ser Thr Glu Gly Pro Ala
                        1               5                  10

 gcc ctg ctg gac caa gca aaa cta agc ctt ttg gtt tgg gta tta tgt      760
 Ala Leu Leu Asp Gln Ala Lys Leu Ser Leu Leu Val Trp Val Leu Cys
              15                  20                  25

 ttc gtt ttg tta ttt gtt tgt ttt tgt ggc ttg tct tat gtc gtg ata      808
 Phe Val Leu Leu Phe Val Cys Phe Cys Gly Leu Ser Tyr Val Val Ile
          30                  35                  40

 gca caa gtg cca gtc gga ttg ctc tgt att aca gaa tag tgtttttaat       857
 Ala Gln Val Pro Val Gly Leu Leu Cys Ile Thr Glu 
      45                  50                  55

 tcatcaatgt tctagttaat gtctacctca gcacctcctc ttagcctaat tttaggaggt    917

 tgcccaattt tgtttcttca attttactgg ttactttttt gtacaaatca atctctttct    977

 ctctctcctc cccacctctc acccttgccc tctccatctc cctctcccgc cctcccctcc   1037

 tccctctggc tccccgtctc atttctgtcc actccattct ctctccctct ctcctgcctc   1097

 ctgctgcccc ctccccagcc cacttccccg agttgtgctt gccgctcctt atctgttcta   1157

 gttccgaagc agtttcactc gaagttgtgc agtcctggtt gcagctttcc gcatctgcct   1217

 tcgtttcgtg tagattgacg cgtttctttg taatttcagt gtttctgaca agatttaaaa   1277

 aaaaaaaaa                                                           1286




      <210> 85
      <211> 1463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(876)

      <400> 85
  atg gga gtg gcg gcg cgg ccc cca gcc ctg cgg cac tgg ttc agc cac      48
  Met Gly Val Ala Ala Arg Pro Pro Ala Leu Arg His Trp Phe Ser His
    1               5                  10                  15

 tca att cct ctc gct atc ttc gcg ctg ctg ctg ctt tat ctc agt gtt       96
 Ser Ile Pro Leu Ala Ile Phe Ala Leu Leu Leu Leu Tyr Leu Ser Val
              20                  25                  30

 cgg agc cta ggc gcc cgc tcg ggc tgc gga ccc agg gcg cag ccc tgc      144
 Arg Ser Leu Gly Ala Arg Ser Gly Cys Gly Pro Arg Ala Gln Pro Cys
          35                  40                  45

 gtt cca ggg gaa acg gcg ccc ttc cag gtc cgg cag gag tcg gga acc      192
 Val Pro Gly Glu Thr Ala Pro Phe Gln Val Arg Gln Glu Ser Gly Thr
      50                  55                  60

 ctg gag gcc ccg gag agg aaa cag cct ccg tgt ctg ggc cct cgg ggg      240
 Leu Glu Ala Pro Glu Arg Lys Gln Pro Pro Cys Leu Gly Pro Arg Gly
  65                  70                  75                  80

 atg ctg ggc cgc atg atg agg cgg ttc cac gcc agt ctg aaa ccc gaa      288
 Met Leu Gly Arg Met Met Arg Arg Phe His Ala Ser Leu Lys Pro Glu
                  85                  90                  95

 ggg gat gtg ggg ctg tcg ccg tac ctg gcg gga tgg agg gca ctc gtc      336
 Gly Asp Val Gly Leu Ser Pro Tyr Leu Ala Gly Trp Arg Ala Leu Val
             100                 105                 110

 gag ttc ctg act ccc ctc ggc tcc gtc ttc gcc ttc gcc act agg gag      384
 Glu Phe Leu Thr Pro Leu Gly Ser Val Phe Ala Phe Ala Thr Arg Glu
         115                 120                 125

 gcc ttc acc aag gtg aca gac ctg gag gct cgg gtg cac ggc ccg gac      432
 Ala Phe Thr Lys Val Thr Asp Leu Glu Ala Arg Val His Gly Pro Asp
     130                 135                 140

 gcg gag cac tac tgg tcg ctg gcg gcc atg gcg gcg tgg gag cgg agg      480
 Ala Glu His Tyr Trp Ser Leu Ala Ala Met Ala Ala Trp Glu Arg Arg
 145                 150                 155                 160

 gcg gga ctg ctg gag cag ccg ggg gcg gcc ccc cgg gac ccg acc cgg      528
 Ala Gly Leu Leu Glu Gln Pro Gly Ala Ala Pro Arg Asp Pro Thr Arg
                 165                 170                 175

 agc tcg ggc tct cgc acg ctg ctc ctg ctg cac cgc gcg ctg cgc tgg      576
 Ser Ser Gly Ser Arg Thr Leu Leu Leu Leu His Arg Ala Leu Arg Trp
             180                 185                 190

 tcc cag ctc tgc ctc cac cgg gtg gcg acc ggc gcg ctg gga ggc ccg      624
 Ser Gln Leu Cys Leu His Arg Val Ala Thr Gly Ala Leu Gly Gly Pro
         195                 200                 205

 gaa gcg ggc gtg cag tgc agc gac gcc tac cgt gcg gcc ctg ggt ccg      672
 Glu Ala Gly Val Gln Cys Ser Asp Ala Tyr Arg Ala Ala Leu Gly Pro
     210                 215                 220

 cat cac ccc tgg ctg gtc cga cag acc gcc cgc ctc gcc ttc ctc gcc      720
 His His Pro Trp Leu Val Arg Gln Thr Ala Arg Leu Ala Phe Leu Ala
 225                 230                 235                 240

 ttc ccg ggt cgc cgc cgc ctg ctg gag ctg gcg tgt ccc gga gcc acc      768
 Phe Pro Gly Arg Arg Arg Leu Leu Glu Leu Ala Cys Pro Gly Ala Thr
                 245                 250                 255

 gag gcg gag gcg cgg gcc gcg ctg ctc cgg gcc gcc ggc acc ttg gag      816
 Glu Ala Glu Ala Arg Ala Ala Leu Leu Arg Ala Ala Gly Thr Leu Glu
             260                 265                 270

 gat gtc tac aac cgc acc cag agc ctg ctg gcc gag cgc ggc ctg ctc      864
 Asp Val Tyr Asn Arg Thr Gln Ser Leu Leu Ala Glu Arg Gly Leu Leu
         275                 280                 285

 cag ctg gcc taa gac ggcggctgcg gggaccggcg ggaacggagc ggaccgcccg      919
 Gln Leu Ala 
     290

 gggtggggcc gcgcagcccg gggtcagtcc tgcagcccgc gccgcggccg cctccgtatc    979

 ccgcctcttc cgtgacgtcg ccgcggcgag ggccgccccc ggcagggaat ggcgttgagc   1039

 tccctctgtc cgcagtctcg gaaagacggg aggagctgtg aggaataaaa aagcaatatt   1099

 tggcagcgtc gacgtagggc gttttgtgtg atgacgacag gcgcttaagg gaaataaaaa   1159

 acgaaggtga gaagatgtgt catctctgtt ctcggcagcc gagagactca cgctcccccg   1219

 gcctatcgta gtcactcccg tggcttcggt tgccaaacac acgctgagtc tccagcccag   1279

 acttgtccct gagcttcacc cctgtgcagc caagtataca gcaagcatcc tgcacactcc   1339

 acagacgctg caaatgcaac gcgtccaaca cgggtcccac caccatcccc ctaagaacta   1399

 cacctcctcc tgtgttccct gtctctgtga ataaatggca ccctcaccct tcaaaaaaaa   1459

 aaaa                                                                1463




      <210> 86
      <211> 2316
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(1392)

      <400> 86
 ggctgttttt ctggagagag acttagagcc gagtgggaca aagcctgggg ctgggcgggg     60

 gcc  atg gcg ctg cca tcc cga atc ctg ctt tgg aaa ctt gtg ctt ctg     108
      Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu
        1               5                  10                  15

 cag agc tct gct gtt ctc ctg cac tca ggg tcc tcg gta ccc gcc gct      156
 Gln Ser Ser Ala Val Leu Leu His Ser Gly Ser Ser Val Pro Ala Ala
                  20                  25                  30

 gct ggc agc tcc gtg gtg tcc gag tcc gcg gtg agc tgg gag gcg ggc      204
 Ala Gly Ser Ser Val Val Ser Glu Ser Ala Val Ser Trp Glu Ala Gly
              35                  40                  45

 gcc cgg gcg gtg ctg cgc tgc cag agc ccg cgc atg gtg tgg acc cag      252
 Ala Arg Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln
          50                  55                  60

 gac cgg ctg cac gac cgc cag cgc gtg ctc cac tgg gac ctg cgc ggc      300
 Asp Arg Leu His Asp Arg Gln Arg Val Leu His Trp Asp Leu Arg Gly
      65                  70                  75

 ccc ggg ggt ggc ccc gcg cgg cgc ctg ctg gac ttg tac tcg gcg ggc      348
 Pro Gly Gly Gly Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser Ala Gly
  80                  85                  90                  95

 gag cag cgc gtg tac gag gcg cgg gac cgc ggc cgc ctg gag ctc tcg      396
 Glu Gln Arg Val Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu Leu Ser
                 100                 105                 110

 gcc tcg gcc ttc gac gac ggc aac ttc tcg ctg ctc atc cgc gcg gtg      444
 Ala Ser Ala Phe Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val
             115                 120                 125

 gag gag acg gac gcg ggg ctg tac acc tgc aac ctg cac cat cac tac      492
 Glu Glu Thr Asp Ala Gly Leu Tyr Thr Cys Asn Leu His His His Tyr
         130                 135                 140

 tgc cac ctc tac gag agc ctg gcc gtc cgc ctg gag gtc acc gac ggc      540
 Cys His Leu Tyr Glu Ser Leu Ala Val Arg Leu Glu Val Thr Asp Gly
     145                 150                 155

 ccc ccg gcc acc ccc gcc tac tgg gac ggc gag aag gag gtg ctg gcg      588
 Pro Pro Ala Thr Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala
 160                 165                 170                 175

 gtg gcg cgc ggc gca ccc gcg ctt ctg acc tgc gtg aac cgc ggg cac      636
 Val Ala Arg Gly Ala Pro Ala Leu Leu Thr Cys Val Asn Arg Gly His
                 180                 185                 190

 gtg tgg acc gac cgg cac gtg gag gag gct caa cag gtg gtg cac tgg      684
 Val Trp Thr Asp Arg His Val Glu Glu Ala Gln Gln Val Val His Trp
             195                 200                 205

 gac cgg cag ccg ccc ggg gtc ccg cac gac cgc gcg gac cgc ctg ctg      732
 Asp Arg Gln Pro Pro Gly Val Pro His Asp Arg Ala Asp Arg Leu Leu
         210                 215                 220

 gac ctc tac gcg tcg ggc gag cgc cgc gcc tac ggg ccc ctt ttt ctg      780
 Asp Leu Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu
     225                 230                 235

 cgc gac cgc gtg gct gtg ggc gcg gat gcc ttt gag cgc ggt gac ttc      828
 Arg Asp Arg Val Ala Val Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe
 240                 245                 250                 255

 tca ctg cgt atc gag ccg ctg gag gtc gcc gac gag ggc acc tac tcc      876
 Ser Leu Arg Ile Glu Pro Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser
                 260                 265                 270

 tgc cac ctg cac cac cat tac tgt ggc ctg cac gaa cgc cgc gtc ttc      924
 Cys His Leu His His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe
             275                 280                 285

 cac ctg acg gtc gcc gaa ccc cac gcg gag ccg ccc ccc cgg ggc tct      972
 His Leu Thr Val Ala Glu Pro His Ala Glu Pro Pro Pro Arg Gly Ser
         290                 295                 300

 ccg ggc aac ggc tcc agc cac agc ggc gcc cca ggc cca gac ccc aca     1020
 Pro Gly Asn Gly Ser Ser His Ser Gly Ala Pro Gly Pro Asp Pro Thr
     305                 310                 315

 ctg gcg cgc ggc cac aac gtc atc aat gtc atc gtc ccc gag agc cga     1068
 Leu Ala Arg Gly His Asn Val Ile Asn Val Ile Val Pro Glu Ser Arg
 320                 325                 330                 335

 gcc cac ttc ttc cag cag ctg ggc tac gtg ctg gcc acg ctg ctg ctc     1116
 Ala His Phe Phe Gln Gln Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu
                 340                 345                 350

 ttc atc ctg cta ctg gtc act gtc ctc ctg gcc gcc cgc agg cgc cgc     1164
 Phe Ile Leu Leu Leu Val Thr Val Leu Leu Ala Ala Arg Arg Arg Arg
             355                 360                 365

 gga ggc tac gaa tac tcg gac cag aag tcg gga aag tca aag ggg aag     1212
 Gly Gly Tyr Glu Tyr Ser Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys
         370                 375                 380

 gat gtt aac ttg gcg gag ttc gct gtg gct gca ggg gac cag atg ctt     1260
 Asp Val Asn Leu Ala Glu Phe Ala Val Ala Ala Gly Asp Gln Met Leu
     385                 390                 395

 tac agg agt gag gac atc cag cta gat tac aaa aac aac atc ctg aag     1308
 Tyr Arg Ser Glu Asp Ile Gln Leu Asp Tyr Lys Asn Asn Ile Leu Lys
 400                 405                 410                 415

 gag agg gcg gag ctg gcc cac agc ccc ctg cct gcc aag tac atc gac     1356
 Glu Arg Ala Glu Leu Ala His Ser Pro Leu Pro Ala Lys Tyr Ile Asp
                 420                 425                 430

 cta gac aaa ggg ttc cgg aag gag aac tgc aaa tag ggag gccctgggct     1406
 Leu Asp Lys Gly Phe Arg Lys Glu Asn Cys Lys 
             435                 440

 cctggctggg ccagcagctg cacctctcct gtctgtgctc ctcggggcat ctcctgatgc   1466

 tccggggctc accccccttc cagcggctgg tcccgctttc ctggaatttg gcctgggcgt   1526

 atgcagaggc cgcctccaca cccctccccc aggggcttgg tggcagcata gcccccaccc   1586

 ctgcggcctt tgctcacggg tggccctgcc cacccctggc acaaccaaaa tcccactgat   1646

 gcccatcatg ccctcagacc cttctgggct ctgcccgctg ggggcctgaa gacattcctg   1706

 gaggacactc ccatcagaac ctggcagccc caaaactggg gtcagcctca gggcaggagt   1766

 cccactcctc cagggctctg ctcgtccggg gctgggagat gttcctggag gaggacactc   1826

 ccatcagaac ttggcagcct tgaagttggg gtcagcctcg gcaggagtcc cactcctcct   1886

 ggggtgctgc ctgccaccaa gagctccccc acctgtacca ccatgtggga ctccaggcac   1946

 catctgttct ccccagggac ctgctgactt gaatgccagc ccttgctcct ctgtgttgct   2006

 ttgggccacc tggggctgca ccccctgccc tttctctgcc ccatccctac cctagccttg   2066

 ctctcagcca ccttgatagt cactgggctc cctgtgactt ctgaccctga cacccctccc   2126

 ttggactctg cctgggctgg agtctagggc tggggctaca tttggcttct gtactggctg   2186

 aggacagggg agggagtgaa gttggtttgg ggtggcctgt gttgccactc tcagcacccc   2246

 acatttgcat ctgctggtgg acctgccacc atcacaataa agtccccatc tgatttttaa   2306

 aaaaaaaaaa                                                          2316




      <210> 87
      <211> 2709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (50)..(1000)

      <400> 87
 gaagccaaac ttggtccccc ggctcgcgga gtgcctgcga gcggtgctc    atg gcg      55
                                                          Met Ala
                                                            1

 ctc tat gag ctc ttc tct cac ccg gtc gag cgc agt tac cgc gcg ggg      103
 Leu Tyr Glu Leu Phe Ser His Pro Val Glu Arg Ser Tyr Arg Ala Gly
           5                  10                  15

 ctc tgc tcc aaa gcc gcg ctg ttc ctg ctg ctg gcc gct gcg ctc acg      151
 Leu Cys Ser Lys Ala Ala Leu Phe Leu Leu Leu Ala Ala Ala Leu Thr
      20                  25                  30

 tac atc ccg ccg ctg ctg gtg gcc ttc cgg agc cac ggg ttt tgg ctg      199
 Tyr Ile Pro Pro Leu Leu Val Ala Phe Arg Ser His Gly Phe Trp Leu
  35                  40                  45                  50

 aag cgg agc agc tac gag gag cag ccg acc gtg cgc ttc caa cac cag      247
 Lys Arg Ser Ser Tyr Glu Glu Gln Pro Thr Val Arg Phe Gln His Gln
                  55                  60                  65

 gtg ctg ctc gtg gcc ctg ctc gga ccc gaa agc gac ggg ttc ctc gcc      295
 Val Leu Leu Val Ala Leu Leu Gly Pro Glu Ser Asp Gly Phe Leu Ala
              70                  75                  80

 tgg agc acg ttc ccc gcc ttc aac cgg ctg caa ggg gat cgc ctg cgc      343
 Trp Ser Thr Phe Pro Ala Phe Asn Arg Leu Gln Gly Asp Arg Leu Arg
          85                  90                  95

 gtc ccg ctc gtt tcg act aga gaa gaa gac agg aac cag gat ggg aag      391
 Val Pro Leu Val Ser Thr Arg Glu Glu Asp Arg Asn Gln Asp Gly Lys
     100                 105                 110

 acg gac atg tta cat ttt aag ctg gag ctt ccc ctg cag tcc acg gag      439
 Thr Asp Met Leu His Phe Lys Leu Glu Leu Pro Leu Gln Ser Thr Glu
 115                 120                 125                 130

 cac gtt ctc ggt gtg cag ctc atc ctg act ttc tcc tat cga tta cac      487
 His Val Leu Gly Val Gln Leu Ile Leu Thr Phe Ser Tyr Arg Leu His
                 135                 140                 145

 agg atg gcg acc ctc gtg atg cag agc atg gcg ttt ctc cag tcc tcc      535
 Arg Met Ala Thr Leu Val Met Gln Ser Met Ala Phe Leu Gln Ser Ser
             150                 155                 160

 ttt cct gtc ccg gga tcc cag tta tac gtg aac gga gac ctg agg ctg      583
 Phe Pro Val Pro Gly Ser Gln Leu Tyr Val Asn Gly Asp Leu Arg Leu
         165                 170                 175

 cag cag aag cag ccg ctg agc tgt ggt ggc cta gat gcc cga tac aac      631
 Gln Gln Lys Gln Pro Leu Ser Cys Gly Gly Leu Asp Ala Arg Tyr Asn
     180                 185                 190

 ata tcc gtg atc aac ggg acc agc ccc ttt gcc tat gac tac gac ctc      679
 Ile Ser Val Ile Asn Gly Thr Ser Pro Phe Ala Tyr Asp Tyr Asp Leu
 195                 200                 205                 210

 acc cat att gtt gct gcc tac cag gag agg aac gtt acc acc gtc ctg      727
 Thr His Ile Val Ala Ala Tyr Gln Glu Arg Asn Val Thr Thr Val Leu
                 215                 220                 225

 aat gat ccc aac ccc atc tgg ctg gtg ggc agg gcc gca gat gct cca      775
 Asn Asp Pro Asn Pro Ile Trp Leu Val Gly Arg Ala Ala Asp Ala Pro
             230                 235                 240

 ttt gtg att aat gct atc atc cga tac cct gtg gaa gtc att tct tat      823
 Phe Val Ile Asn Ala Ile Ile Arg Tyr Pro Val Glu Val Ile Ser Tyr
         245                 250                 255

 cag cca gga ttc tgg gag atg gta aag ttc gcc tgg gtg cag tat gtc      871
 Gln Pro Gly Phe Trp Glu Met Val Lys Phe Ala Trp Val Gln Tyr Val
     260                 265                 270

 agc atc ctg ctt atc ttc ctc tgg gtg ttt gaa aga atc aag atc ttc      919
 Ser Ile Leu Leu Ile Phe Leu Trp Val Phe Glu Arg Ile Lys Ile Phe
 275                 280                 285                 290

 gtg ttt cag aat cag gtg gtg acc acc att cct gtg aca gtg acg ccc      967
 Val Phe Gln Asn Gln Val Val Thr Thr Ile Pro Val Thr Val Thr Pro
                 295                 300                 305

 cgg gga gac ttg tgt aag gag cac tta tcc tag aaaggcca tttctgaaga     1018
 Arg Gly Asp Leu Cys Lys Glu His Leu Ser 
             310                 315

 ctcagcagga ccgtggctgc ctcattgtca tcttctggga acatcttagg accttttgaa   1078

 agagcccagc ggacacctgc gggcttgtgt gcttttccct cagagacaac ggttctttcc   1138

 ggttttgctc tacacagttc cgtatcttca gagctcctgc agaattgtca gggactagtt   1198

 tgtggaaagg tctgagagtt cctggaggct ataattagct ttttgggttt tccttctttg   1258

 ccttagcgtt gaatttcagg agaaaattgc agtcagttca gacatcttgg aaagagtccc   1318

 atctctggtc aagcagagac ttttcctctg ttgaactgag gaacacactg tgcatttcta   1378

 ccttctgttg tgagccactc ttactctttt cagggctctc ttgtgacaaa catgccaatc   1438

 actagcactt tgcacccctg ggcttctcca tttcccattc acagctttga tttccagagc   1498

 tgaggccttt aactggagac ctggaggggc agggcccaag ggcaagggcc gcattagcac   1558

 aggcaatcag ggagggccgc tgaaggacac ttggaccgtc cacctgcccc agcccaacag   1618

 tcagtcatct gtcatcagct cagctgagca gccctggatc tttgccgtac tgtgactggg   1678

 ctctttgccc tatttttccc tctgtctgtg cccctggatg gcaggctgaa gtcagagggg   1738

 ctgtttcatt ctcagccccc tcagcagcac tgggggaaga aagcattgtc acaacaggtt   1798

 ctttctggcc ctcacccaac agcctgggca cttggccctc ctcctccttg acagccctcc   1858

 cccttcctgc aaaggacagg ggcgacaggg gttggtgttg ggattggctc ccgctgcctg   1918

 acaaccacaa gtttatttgg aaggctagcg ggaagcccag cggctggcgt ttcccttgac   1978

 taaggaacag ggtgcccatc agagtggggc gggcagcttt gggaaggaca caagaagcag   2038

 taagagtgta aagaggatgc tggcctgggc aggccagtcc agcctggcca ctagcagaat   2098

 accaagcagt ccagtggatt accctcgtgg ctaagcaagt gtctgcagga gcagagatgg   2158

 ctggaagggg cctctgcaca cggaagatgg cttgttcagc ccattcacct cctgaggatg   2218

 tgggcagtct cctccaagaa cacatggagc tgcttcctga tcccaagcag gtcattgcca   2278

 ctggaaggac atggccccgg tgatccatgc ttcatgccca cccagaaaca cacccctcag   2338

 tgtgtgcctc agtttacttt ggagatcagt tgtcgttttt agtgctcctt taggcttact   2398

 aaaacagttt tggaaacaaa gctattttga agtattcaag cagaggaatt ccctaacact   2458

 gacccccttg tcttttttta atattcaggc tgttttatat gcctaaattt ttttcttaag   2518

 atctaaacga aaaatagttt cttgtttaaa ttcacataag gcaatgagat atggaaagat   2578

 gacaagatac gtataaacat tggtttgcat tttattaaat tattctaatg caaatcttgt   2638

 ataaagaacc catgatgttt tgtaactttc taattaaaat gttcaaaatg aaaaaaaaaa   2698

 aaaaaaaaaa a                                                        2709




      <210> 88
      <211> 1761
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1017)

      <400> 88
 ccctcccgac tccccagttt catcggactc cctggcccca tcccgtcccc gccctggccc     60

 ctttgtgccc cttctcatcg ttttctccct ccttcccggg cttggcgtcc cttctccacc    120

 cctaactcct tccactcggc ctccctgccc cttcacggcc cgcctgcctc cctgcccaag    180

 tcctgagcca cc    atg ctg acc ccg atg gtg gcc ggg ggg gtg gtg ttc     228
                  Met Leu Thr Pro Met Val Ala Gly Gly Val Val Phe
                    1               5                  10

 ccc gga ctc ttc ctc ctc tcc aag aac acg ctc cag cgg ctg ccc cag      276
 Pro Gly Leu Phe Leu Leu Ser Lys Asn Thr Leu Gln Arg Leu Pro Gln
          15                  20                  25

 cta cgc tgg gag gag gcc gac gca gtc att gtc tca gcc agg ctg gtg      324
 Leu Arg Trp Glu Glu Ala Asp Ala Val Ile Val Ser Ala Arg Leu Val
      30                  35                  40

 tcc tct gtc cag gcc atc atg gcc tcc act gcc ggc tac atc gtc tcc      372
 Ser Ser Val Gln Ala Ile Met Ala Ser Thr Ala Gly Tyr Ile Val Ser
  45                  50                  55                  60

 acc tcc tgc aag cac atc att gat gac caa cac tgg ctg tcc tct gcc      420
 Thr Ser Cys Lys His Ile Ile Asp Asp Gln His Trp Leu Ser Ser Ala
                  65                  70                  75

 tac acg caa ttt gct gtg ccc tac ttc atc tac gac atc tac gcc atg      468
 Tyr Thr Gln Phe Ala Val Pro Tyr Phe Ile Tyr Asp Ile Tyr Ala Met
              80                  85                  90

 ttc ctc tgt cac tgg cac aag cac cag gtc aaa ggg cat gga ggg gac      516
 Phe Leu Cys His Trp His Lys His Gln Val Lys Gly His Gly Gly Asp
          95                 100                 105

 gac gga gcg gcc aga gcc ccg ggc agc acg tgg gcc ata gcg cgt ggc      564
 Asp Gly Ala Ala Arg Ala Pro Gly Ser Thr Trp Ala Ile Ala Arg Gly
     110                 115                 120

 tac ctg cac aag gag ttc ctc atg gtg ctc cac cat gcc gcc atg gtg      612
 Tyr Leu His Lys Glu Phe Leu Met Val Leu His His Ala Ala Met Val
 125                 130                 135                 140

 ctg gtg tgc ttc cca ctc tca gtg gtg tgg cga cag ggt aag gga gac      660
 Leu Val Cys Phe Pro Leu Ser Val Val Trp Arg Gln Gly Lys Gly Asp
                 145                 150                 155

 ttc ttt ctg ggt tgc atg ttg atg gca gag gtc agc acg ccc ttc gtc      708
 Phe Phe Leu Gly Cys Met Leu Met Ala Glu Val Ser Thr Pro Phe Val
             160                 165                 170

 tgc ctt ggc aag atc ctc atc cag tac aag cag cag cac aca ctg ctg      756
 Cys Leu Gly Lys Ile Leu Ile Gln Tyr Lys Gln Gln His Thr Leu Leu
         175                 180                 185

 cac aag gtg aac ggg gcc ctg atg ctg ctc agc ttc ctc tgc tgc cgg      804
 His Lys Val Asn Gly Ala Leu Met Leu Leu Ser Phe Leu Cys Cys Arg
     190                 195                 200

 gtg ctg ctc ttt ccc tac ctg tac tgg gcc tac ggg cgc cat gcc ggc      852
 Val Leu Leu Phe Pro Tyr Leu Tyr Trp Ala Tyr Gly Arg His Ala Gly
 205                 210                 215                 220

 ctg ccc ctg ctg gcc gtg ccc ctg gcc atc cct gcc cac gtc aac ctg      900
 Leu Pro Leu Leu Ala Val Pro Leu Ala Ile Pro Ala His Val Asn Leu
                 225                 230                 235

 ggc gct gcg ctg ctc ctg gcc cct cag ctc tac tgg ttc ttc ctc atc      948
 Gly Ala Ala Leu Leu Leu Ala Pro Gln Leu Tyr Trp Phe Phe Leu Ile
             240                 245                 250

 tgc cgt ggg gcc tgc cgc ctc ttc tgg ccc cgc tcc cgg ccg ccc ccg      996
 Cys Arg Gly Ala Cys Arg Leu Phe Trp Pro Arg Ser Arg Pro Pro Pro
         255                 260                 265

 gcc tgc cag gcc cag gac tga gg ccgggggccg ggaccctccc cctccccacc     1049
 Ala Cys Gln Ala Gln Asp 
     270

 cccacccccg tggagacagg gctctggggc tgatggctgg ggttgggagc cagggtcctc   1109

 ttgcccggac aaccccagga ctgacgatga ccccgaaagg gaagaggccc catctctcgg   1169

 ggactgaggg ggtggagaga ggggacctct tccccctact ctgccccctt cctgcacacc   1229

 cttgcgctgg aggaggggag ggggcaccgc ctcccaccca ctgagggcag gagggcttgt   1289

 ggggagggac accaacaggg tttcaagggg accaggagtc agaatgtggg gagacgcctc   1349

 tgccaaggcc atcccagccc ctatgctgcc atcccccagg gctccccatc acccgagagg   1409

 agaggacgcc ccaactaacc cccgctggcc ctcgggcctc ccgagtggcc ggctgcaacc   1469

 acggctcctc tccagggtag gccagcttga ggaatcttat ttattttatt tatttaccca   1529

 aatttgaact agtctgttgg gttgggggaa ggaggtggct gctaccccca agccttccca   1589

 gtgctgacaa ccccgggggc aggcgagggc gcccagtccc tcaccatcgg ctgcacatcg   1649

 cgccctcggg ccctgccatg tccctggtgc tactgacctc tcaaggcttc ctccaatctg   1709

 gggtcggggg accctgggag gtgctttaca gaccgctaat aaaagacgat at           1761




      <210> 89
      <211> 1684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1561)

      <400> 89
 gccacagccg cgggtgcgtg gtcgtgcggc aagtgagcga tttggtgaac agacactccc     60

 ttctgtagcc   atg gat tgt tac aga act tca cta agc agt tcc tgg att     109
              Met Asp Cys Tyr Arg Thr Ser Leu Ser Ser Ser Trp Ile
                1               5                  10

 tac ccc act gtg atc ctc tgc tta ttt ggt ttt ttc tcc atg atg aga      157
 Tyr Pro Thr Val Ile Leu Cys Leu Phe Gly Phe Phe Ser Met Met Arg
      15                  20                  25

 ccc tca gaa cca ttc ctt atc cca tat tta tct gga cca gat aaa aac      205
 Pro Ser Glu Pro Phe Leu Ile Pro Tyr Leu Ser Gly Pro Asp Lys Asn
  30                  35                  40                  45

 ctg acc agt gca gag ata aca aat gag atc ttc ccc gtt tgg aca tac      253
 Leu Thr Ser Ala Glu Ile Thr Asn Glu Ile Phe Pro Val Trp Thr Tyr
                  50                  55                  60

 tcc tac ctg gtg ctg ctg ctg cct gtg ttt gtc ctc acc gat tat gtc      301
 Ser Tyr Leu Val Leu Leu Leu Pro Val Phe Val Leu Thr Asp Tyr Val
              65                  70                  75

 cgc tac aag cca gtc atc atc ttg caa ggt atc agt ttc atc att acc      349
 Arg Tyr Lys Pro Val Ile Ile Leu Gln Gly Ile Ser Phe Ile Ile Thr
          80                  85                  90

 tgg ctg ctg ctg ttg ttt ggc caa gga gtg aag acc atg cag gtt gta      397
 Trp Leu Leu Leu Leu Phe Gly Gln Gly Val Lys Thr Met Gln Val Val
      95                 100                 105

 gag ttc ttc tat ggg atg gtc acc gcc gcc gag gtg gcc tac tac gcc      445
 Glu Phe Phe Tyr Gly Met Val Thr Ala Ala Glu Val Ala Tyr Tyr Ala
 110                 115                 120                 125

 tac ata tac agc gtg gtc agc ccc gag cac tac cag aga gtg agc ggc      493
 Tyr Ile Tyr Ser Val Val Ser Pro Glu His Tyr Gln Arg Val Ser Gly
                 130                 135                 140

 tac tgc agg agc gtc acg ctg gcc gcc tac aca gca ggg tcg gtg ctg      541
 Tyr Cys Arg Ser Val Thr Leu Ala Ala Tyr Thr Ala Gly Ser Val Leu
             145                 150                 155

 gct caa ctc ttg gta tcc ctg gcg aac atg tcg tac ttt tac ctc aac      589
 Ala Gln Leu Leu Val Ser Leu Ala Asn Met Ser Tyr Phe Tyr Leu Asn
         160                 165                 170

 gtc ata tcc ttg gcc tct gtc tcc gtg gct ttc ctt ttc tca ctt ttc      637
 Val Ile Ser Leu Ala Ser Val Ser Val Ala Phe Leu Phe Ser Leu Phe
     175                 180                 185

 cta cca atg ccc aag aaa agc atg ttt ttt cat gca aaa ccc agc aga      685
 Leu Pro Met Pro Lys Lys Ser Met Phe Phe His Ala Lys Pro Ser Arg
 190                 195                 200                 205

 gaa ata aag aag tca tca agc gtg aat cca gta tta gag gaa act cac      733
 Glu Ile Lys Lys Ser Ser Ser Val Asn Pro Val Leu Glu Glu Thr His
                 210                 215                 220

 gaa ggt gaa gca cca ggc tgt gaa gag cag aaa ccc aca tca gaa ata      781
 Glu Gly Glu Ala Pro Gly Cys Glu Glu Gln Lys Pro Thr Ser Glu Ile
             225                 230                 235

 ctc agc act tca ggg aag ctg aat aag ggc cag ctg aac agc ctg aaa      829
 Leu Ser Thr Ser Gly Lys Leu Asn Lys Gly Gln Leu Asn Ser Leu Lys
         240                 245                 250

 cca agc aat gtg act gtg gac gtt ttt gtg cag tgg ttc caa gat ttg      877
 Pro Ser Asn Val Thr Val Asp Val Phe Val Gln Trp Phe Gln Asp Leu
     255                 260                 265

 aag gag tgc tac tcc tca aaa cgt ctt ttc tac tgg tct cta tgg tgg      925
 Lys Glu Cys Tyr Ser Ser Lys Arg Leu Phe Tyr Trp Ser Leu Trp Trp
 270                 275                 280                 285

 gct ttc gcc aca gca ggt ttt aac cag gtt ttg aac tat gtt caa atc      973
 Ala Phe Ala Thr Ala Gly Phe Asn Gln Val Leu Asn Tyr Val Gln Ile
                 290                 295                 300

 ctg tgg gat tac aag gcg cca tcc caa gat tct tcc atc tat aat ggg     1021
 Leu Trp Asp Tyr Lys Ala Pro Ser Gln Asp Ser Ser Ile Tyr Asn Gly
             305                 310                 315

 gcc gta gaa gct att gca acc ttt gga ggg gct gtg gct gcc ttt gca     1069
 Ala Val Glu Ala Ile Ala Thr Phe Gly Gly Ala Val Ala Ala Phe Ala
         320                 325                 330

 gtg ggt tat gtg aaa gtc aac tgg gac ctt ctg gga gag ctg gct ctg     1117
 Val Gly Tyr Val Lys Val Asn Trp Asp Leu Leu Gly Glu Leu Ala Leu
     335                 340                 345

 gtg gtc ttc tca gtt gtc aat gcc ggt tct tta ttt ctc atg cat tac     1165
 Val Val Phe Ser Val Val Asn Ala Gly Ser Leu Phe Leu Met His Tyr
 350                 355                 360                 365

 aca gcc aat atc tgg gcg tgc tat gct ggc tat ttg ata ttc aag tcc     1213
 Thr Ala Asn Ile Trp Ala Cys Tyr Ala Gly Tyr Leu Ile Phe Lys Ser
                 370                 375                 380

 agc tat atg ctt ctt ata acc ata gca gta ttt cag att gca gtt aat     1261
 Ser Tyr Met Leu Leu Ile Thr Ile Ala Val Phe Gln Ile Ala Val Asn
             385                 390                 395

 ctg aat gtg gaa cgc tat gcc ttg gta ttt gga atc aac acc ttt att     1309
 Leu Asn Val Glu Arg Tyr Ala Leu Val Phe Gly Ile Asn Thr Phe Ile
         400                 405                 410

 gcc ttg gtg att cag acc atc atg act gtg att gta gta gat cag aga     1357
 Ala Leu Val Ile Gln Thr Ile Met Thr Val Ile Val Val Asp Gln Arg
     415                 420                 425

 ggg ctc aac ttg cca gtc agc att cag ttt tta gtt tat ggg agc tat     1405
 Gly Leu Asn Leu Pro Val Ser Ile Gln Phe Leu Val Tyr Gly Ser Tyr
 430                 435                 440                 445

 ttt gca gta att gct gga att ttc cta atg aga agc atg tat att acc     1453
 Phe Ala Val Ile Ala Gly Ile Phe Leu Met Arg Ser Met Tyr Ile Thr
                 450                 455                 460

 tac tca acc aaa tcc cag aag gat gta cag agc cct gct cca agt gag     1501
 Tyr Ser Thr Lys Ser Gln Lys Asp Val Gln Ser Pro Ala Pro Ser Glu
             465                 470                 475

 aat cca gat gtg tct cac cca gag gaa gag agt aat atc atc atg tca     1549
 Asn Pro Asp Val Ser His Pro Glu Glu Glu Ser Asn Ile Ile Met Ser
         480                 485                 490

 aca aaa ctc taa cct catcgcaaca aacgcaacag tggctttcaa agttatgcaa     1604
 Thr Lys Leu 
     495

 taataaggaa agattttgag atgggtggca tatgttttgc cataacttga catgctttgc   1664

 aaatcctcag aacaacgaca                                               1684




      <210> 90
      <211> 548
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(498)

      <400> 90
 gtcctctggg ccacgctcca cttgcccgct tccacccgga aagcccccca ggctgagtgc     60

 ggc  atg atc tcc atc acc gaa tgg cag aag att ggt gtg ggg atc act     108
      Met Ile Ser Ile Thr Glu Trp Gln Lys Ile Gly Val Gly Ile Thr
        1               5                  10                  15

 ggt ttc ggc atc ttc ttc atc ctc ttt gga aca ctg ctg tac ttt gat      156
 Gly Phe Gly Ile Phe Phe Ile Leu Phe Gly Thr Leu Leu Tyr Phe Asp
                  20                  25                  30

 tcc gtg ctc ctg gcc ttt gga aac ctg ctg ttc ctg acg ggc ctg tcc      204
 Ser Val Leu Leu Ala Phe Gly Asn Leu Leu Phe Leu Thr Gly Leu Ser
              35                  40                  45

 ctc atc att ggc ctg agg aag acc ttt tgg ttc ttc ttc caa cgg cac      252
 Leu Ile Ile Gly Leu Arg Lys Thr Phe Trp Phe Phe Phe Gln Arg His
          50                  55                  60

 aaa ctc aag gga acc agc ttc ctc ctg ggg ggt gtg gtt atc gtg ctc      300
 Lys Leu Lys Gly Thr Ser Phe Leu Leu Gly Gly Val Val Ile Val Leu
      65                  70                  75

 cta cgc tgg ccc ctc ctc ggc atg ttc ctg gaa acc tac gga ttc ttc      348
 Leu Arg Trp Pro Leu Leu Gly Met Phe Leu Glu Thr Tyr Gly Phe Phe
  80                  85                  90                  95

 agc ctc ttt aag ggc ttt ttc cct gtc gcc ttc ggc ttc ctg ggc aat      396
 Ser Leu Phe Lys Gly Phe Phe Pro Val Ala Phe Gly Phe Leu Gly Asn
                 100                 105                 110

 gtc tgc aac atc ccc ttc ctg ggt gcg gta agc agt atg atg cct gca      444
 Val Cys Asn Ile Pro Phe Leu Gly Ala Val Ser Ser Met Met Pro Ala
             115                 120                 125

 gcc ctg cgg tca tcc ctg ggg agt gaa gcg gag tac acg gag ggg agc      492
 Ala Leu Arg Ser Ser Leu Gly Ser Glu Ala Glu Tyr Thr Glu Gly Ser
         130                 135                 140

 tgg taa aactgctgcc ccaggggata gggcctctcc cctgtctccc ctcagacccc       548
 Trp 






      <210> 91
      <211> 2908
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (575)..(2062)

      <400> 91
 ggggatgttt taagaatgtc tctcagaggt agagtgtgtc tatggaaggg gttgtcatgg     60

 taacagcttc tgttggcttc tagccctacc ttttctggac acattcatgc tagagggatg    120

 gttataggtt gctataataa ctgacatccc tcccattcac cccaccccac tcctgagaca    180

 ccccaggtgg tgcccgagat tataggactt caagagaaag gattccctga cctttctctt    240

 gccacttttg tggataagat gaaattgtgc tctattgtac ggaaatggct gatttgggat    300

 tttctggttc tcctcctctc aggagcgcag ctcagctggg ctggaactgc cctcctggaa    360

 ctcccccagc ctacaaccta ggaggtgcag ggactgaggc tcaggccaaa tcgcaactca    420

 gacccagtga acccaaggcc tgaagagaat ttggattcat ttaccttgtt ttgtggggac    480

 tggagagaca agtaaactct cagagtaact gtcccctctg actaccattt ctaaggatgc    540

 cccggaggcc cagctagccc cagacttcgg cccc    atg cgg ctc acc cgc tgc     592
                                          Met Arg Leu Thr Arg Cys
                                            1               5

 cag gct gcc ctg gcg gcc gcc atc acc ctc aac ctt ctg gtc ctc ttc      640
 Gln Ala Ala Leu Ala Ala Ala Ile Thr Leu Asn Leu Leu Val Leu Phe
              10                  15                  20

 tat gtc tcg tgg ctg cag cac cag cct agg aat tcc cgg gcc cgg ggg      688
 Tyr Val Ser Trp Leu Gln His Gln Pro Arg Asn Ser Arg Ala Arg Gly
          25                  30                  35

 ccc cgt cgt gcc tct gct gcc ggc ccc cgt gtc acc gtc ctg gtg cgg      736
 Pro Arg Arg Ala Ser Ala Ala Gly Pro Arg Val Thr Val Leu Val Arg
      40                  45                  50

 gag ttc gag gca ttt gac aac gcg gtg ccc gag ctg gta gac tcc ttc      784
 Glu Phe Glu Ala Phe Asp Asn Ala Val Pro Glu Leu Val Asp Ser Phe
  55                  60                  65                  70

 ctg cag caa gac cca gcc cag ccc gtg gtg gtg gca gcc gac acg ctc      832
 Leu Gln Gln Asp Pro Ala Gln Pro Val Val Val Ala Ala Asp Thr Leu
                  75                  80                  85

 ccc tac ccg ccc ctg gcc ctg ccc cgc atc ccc aac gtg cgt ctg gcg      880
 Pro Tyr Pro Pro Leu Ala Leu Pro Arg Ile Pro Asn Val Arg Leu Ala
              90                  95                 100

 ctg ctc cag ccc gcc ctg gac cgg cca gcc gca gcc tcg cgc ccg gag      928
 Leu Leu Gln Pro Ala Leu Asp Arg Pro Ala Ala Ala Ser Arg Pro Glu
         105                 110                 115

 acc tac gtg gcc acc gag ttt gtg gcc cta gta cct gat ggg gcg cgg      976
 Thr Tyr Val Ala Thr Glu Phe Val Ala Leu Val Pro Asp Gly Ala Arg
     120                 125                 130

 gct gag gca cct ggc ctg ctg gag cgc atg gtg gag gcg ctc cgc gca     1024
 Ala Glu Ala Pro Gly Leu Leu Glu Arg Met Val Glu Ala Leu Arg Ala
 135                 140                 145                 150

 gga agc gca cgt ctg gtg gcc gcc ccg gtt gcc acg gcc aac cct gcc     1072
 Gly Ser Ala Arg Leu Val Ala Ala Pro Val Ala Thr Ala Asn Pro Ala
                 155                 160                 165

 agg tgc ctg gcc ctg aac gtc agc ctg cga gag tgg acc gcc cgc tat     1120
 Arg Cys Leu Ala Leu Asn Val Ser Leu Arg Glu Trp Thr Ala Arg Tyr
             170                 175                 180

 ggc gca gcc ccc gcc gcg ccc cgc tgc gac gcc ctg gac gga gat gct     1168
 Gly Ala Ala Pro Ala Ala Pro Arg Cys Asp Ala Leu Asp Gly Asp Ala
         185                 190                 195

 gtg gtg ctc ctg cgc gcc cgc gac ctc ttc aac ctc tcg gcg ccc ctg     1216
 Val Val Leu Leu Arg Ala Arg Asp Leu Phe Asn Leu Ser Ala Pro Leu
     200                 205                 210

 gcc cgg ccg gtg ggc acc agc ctc ttt ctg cag acc gcc ctt cgc ggc     1264
 Ala Arg Pro Val Gly Thr Ser Leu Phe Leu Gln Thr Ala Leu Arg Gly
 215                 220                 225                 230

 tgg gcg gtg cag ctg ctg gac ttg acc ttc gcc gcg gcg cgc cag ccc     1312
 Trp Ala Val Gln Leu Leu Asp Leu Thr Phe Ala Ala Ala Arg Gln Pro
                 235                 240                 245

 ccg ctg gcc acg gcc cac gcg cgc tgg aag gct gag cgc gag gga cgc     1360
 Pro Leu Ala Thr Ala His Ala Arg Trp Lys Ala Glu Arg Glu Gly Arg
             250                 255                 260

 gct cgg cgg gcg gcg ctg ctc cgc gcg ctg ggc atc cgc cta gtg agc     1408
 Ala Arg Arg Ala Ala Leu Leu Arg Ala Leu Gly Ile Arg Leu Val Ser
         265                 270                 275

 tgg gaa ggc ggg cgg ctg gag tgg ttc ggc tgc aac aag gag acc acg     1456
 Trp Glu Gly Gly Arg Leu Glu Trp Phe Gly Cys Asn Lys Glu Thr Thr
     280                 285                 290

 cgc tgc ttc gga acc gtg gtg ggc gac acg ccc gcc tac ctc tac gag     1504
 Arg Cys Phe Gly Thr Val Val Gly Asp Thr Pro Ala Tyr Leu Tyr Glu
 295                 300                 305                 310

 gag cgc tgg acg ccc ccc tgc tgc ctg cgc gcg ctg cgc gag acc gcc     1552
 Glu Arg Trp Thr Pro Pro Cys Cys Leu Arg Ala Leu Arg Glu Thr Ala
                 315                 320                 325

 cgc tat gtg gtg ggc gtg ctg gag gct gcg ggc gtg cgc tac tgg ctc     1600
 Arg Tyr Val Val Gly Val Leu Glu Ala Ala Gly Val Arg Tyr Trp Leu
             330                 335                 340

 gag ggc ggc tca ctg ctg ggg gcc gcc cgc cac ggg gac atc atc cca     1648
 Glu Gly Gly Ser Leu Leu Gly Ala Ala Arg His Gly Asp Ile Ile Pro
         345                 350                 355

 tgg gac tac gac gtg gac ctg ggc atc tac ttg gag gac gtg ggc aac     1696
 Trp Asp Tyr Asp Val Asp Leu Gly Ile Tyr Leu Glu Asp Val Gly Asn
     360                 365                 370

 tgc gag cag ctg cgg ggg gca gag gcc ggc tcg gtg gtg gat gag cgc     1744
 Cys Glu Gln Leu Arg Gly Ala Glu Ala Gly Ser Val Val Asp Glu Arg
 375                 380                 385                 390

 ggc ttc gta tgg gag aag gcg gtc gag ggc gac ttt ttc cgc gtg cag     1792
 Gly Phe Val Trp Glu Lys Ala Val Glu Gly Asp Phe Phe Arg Val Gln
                 395                 400                 405

 tac agc gaa agc aac cac ttg cac gtg gac ctg tgg ccc ttc tac ccc     1840
 Tyr Ser Glu Ser Asn His Leu His Val Asp Leu Trp Pro Phe Tyr Pro
             410                 415                 420

 cgc aat ggc gtc atg acc aag gac acg tgg ctg gac cac cgg cag gat     1888
 Arg Asn Gly Val Met Thr Lys Asp Thr Trp Leu Asp His Arg Gln Asp
         425                 430                 435

 gtg gag ttt ccc gag cac ttc ctg cag ccg ctg gtg ccc ctg ccc ttt     1936
 Val Glu Phe Pro Glu His Phe Leu Gln Pro Leu Val Pro Leu Pro Phe
     440                 445                 450

 gcc ggc ttc gtg gcg cag gcg cct aac aac tac cgc cgc ttc ctg gag     1984
 Ala Gly Phe Val Ala Gln Ala Pro Asn Asn Tyr Arg Arg Phe Leu Glu
 455                 460                 465                 470

 ctc aag ttc ggg ccc ggg gtc atc gag aac ccc cag tac ccc aac ccg     2032
 Leu Lys Phe Gly Pro Gly Val Ile Glu Asn Pro Gln Tyr Pro Asn Pro
                 475                 480                 485

 gca ctg ctg agt ctg acg gga agc ggc tga a gccctgataa cctcgccttt     2083
 Ala Leu Leu Ser Leu Thr Gly Ser Gly 
             490                 495

 gtttttcggg ggtctgtctg gatgtggaga agctctgtgt gagcggtgag gggtggaggg   2143

 atgtcgcgga gaggggaagg gggaaactga ccaagaaaga aattctaagg agagcatgag   2203

 agaaggctgg cattggcagg aggagagcac caggacgagg atgggaagcg acctccagat   2263

 ttatcaaatg gtcatgccca ctgggagccg tggatatgcg tggggacatc ctgggtcatc   2323

 tcagtcatgg agggagacgg ggatgtcacg ccgtcccgca gggcccagca cagccccaga   2383

 cccgaaaaaa gtgttctgcc caagattccg agagccctgc gctctagggc aggggcagag   2443

 ttttggaaac agtgcaggct ctggagccag actggcgaga ttcaaatcct ggctctatcg   2503

 cttcggagcc aggtgggcct gggggggcgt cgcagtctct ctgtgcctca gttgcttcca   2563

 ggatgcggga cccttggctg caggggttgc ttccgccact agagggcgcg ccggtcccgc   2623

 tcctggtggc ccactgtggc tgcccgggcg acagtacgcc cagggcctgt gttccatagc   2683

 catctactct cttgagcctt tggacttctc tccaagcccc tgtgggaggc ggacagcagt   2743

 gaccacctcc ccttcttttg gactgcgacc tccttccctc ctgggagagc cctgtgacct   2803

 gcatgctact cttaactgtt ctattcaaga ctgaatagaa gtatttcagt cttgcagagg   2863

 aggaaatgct cagagctccg aggtgcggct gtggtcgaga accgg                   2908




      <210> 92
      <211> 1806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (309)..(1448)

      <400> 92
 ggaaactgag ggccagagag aagaagcctt tgcctgtgga tacccagtgc ccagtgggag     60

 agctgggatt tgaaaaaaca agccctgttt gaccccaaag cctcagtcca ctttccgatg    120

 tccccggcat caccaaatgg cccagcttgg gtttctgaac agtaacatta actctggcct    180

 ggtgtctggc ggtgacccag gagctggccc taaagcaagg acctgagtgc aagtaatttt    240

 tttgggaagt aataacagaa aataccagca aggaagaaga cagtgaaccc aaaagaattg    300

 aaaacagg atg ctg ccc atc aca gac cgc ctg ctg cac ctc ctg ggg ctg     350
          Met Leu Pro Ile Thr Asp Arg Leu Leu His Leu Leu Gly Leu
            1               5                  10

 gag aag acg gcg ttc cgc ata tac gcg gtg tcc acc ctt ctc ctc ttc      398
 Glu Lys Thr Ala Phe Arg Ile Tyr Ala Val Ser Thr Leu Leu Leu Phe
  15                  20                  25                  30

 ctg ctc ttc ttc ctg ttc cgc ctg ctg ctg cgg ttc ctg agg ctc tgc      446
 Leu Leu Phe Phe Leu Phe Arg Leu Leu Leu Arg Phe Leu Arg Leu Cys
                  35                  40                  45

 agg agc ttc tac atc acc tgc cgc cgg ctg cgc tgc ttc ccc cag cct      494
 Arg Ser Phe Tyr Ile Thr Cys Arg Arg Leu Arg Cys Phe Pro Gln Pro
              50                  55                  60

 ccc cgg cgc aac tgg ctg ctg ggc cac ctg ggc atg tac ctt cca aat      542
 Pro Arg Arg Asn Trp Leu Leu Gly His Leu Gly Met Tyr Leu Pro Asn
          65                  70                  75

 gag gcg ggc ctt caa gat gag aag aag gta ctg gac aac atg cac cat      590
 Glu Ala Gly Leu Gln Asp Glu Lys Lys Val Leu Asp Asn Met His His
      80                  85                  90

 gta ctc ttg gta tgg atg gga cct gtc ctg ccg ctg ttg gtt ctg gtg      638
 Val Leu Leu Val Trp Met Gly Pro Val Leu Pro Leu Leu Val Leu Val
  95                 100                 105                 110

 cac cct gat tac atc aaa ccc ctt ttg gga gcc tca gct gcc atc gcc      686
 His Pro Asp Tyr Ile Lys Pro Leu Leu Gly Ala Ser Ala Ala Ile Ala
                 115                 120                 125

 ccc aag gat gac ctc ttc tat ggc ttc cta aaa cct tgg cta ggg gat      734
 Pro Lys Asp Asp Leu Phe Tyr Gly Phe Leu Lys Pro Trp Leu Gly Asp
             130                 135                 140

 ggg ctg ctg ctc agc aaa ggt gac aag tgg agc cgg cac cgt cgc ctg      782
 Gly Leu Leu Leu Ser Lys Gly Asp Lys Trp Ser Arg His Arg Arg Leu
         145                 150                 155

 ctg aca ccc gcc ttc cac ttt gac atc ctg aag cct tac atg aag atc      830
 Leu Thr Pro Ala Phe His Phe Asp Ile Leu Lys Pro Tyr Met Lys Ile
     160                 165                 170

 ttc aac cag agc gct gac att atg cat gct aaa tgg cgg cat ctg gca      878
 Phe Asn Gln Ser Ala Asp Ile Met His Ala Lys Trp Arg His Leu Ala
 175                 180                 185                 190

 gag ggc tca gcg gtc tcc ctt gat atg ttt gag cat atc agc ctc atg      926
 Glu Gly Ser Ala Val Ser Leu Asp Met Phe Glu His Ile Ser Leu Met
                 195                 200                 205

 acc ctg gac agt ctt cag aaa tgt gtc ttc agc tac aac agc aac tgc      974
 Thr Leu Asp Ser Leu Gln Lys Cys Val Phe Ser Tyr Asn Ser Asn Cys
             210                 215                 220

 caa gag aag atg agt gat tat atc tcc gct atc att gaa ctg agc gct     1022
 Gln Glu Lys Met Ser Asp Tyr Ile Ser Ala Ile Ile Glu Leu Ser Ala
         225                 230                 235

 ctg tct gtc cgg cgc cag tat cgc ttg cac cac tac ctc gac ttc att     1070
 Leu Ser Val Arg Arg Gln Tyr Arg Leu His His Tyr Leu Asp Phe Ile
     240                 245                 250

 tac tac cgc tcg gcg gat ggg cgg agg ttc cgg cag gcc tgt gac atg     1118
 Tyr Tyr Arg Ser Ala Asp Gly Arg Arg Phe Arg Gln Ala Cys Asp Met
 255                 260                 265                 270

 gtg cac cac ttc acc act gaa gtc atc cag gaa cgg cgg cgg gca ctg     1166
 Val His His Phe Thr Thr Glu Val Ile Gln Glu Arg Arg Arg Ala Leu
                 275                 280                 285

 cgt cag cag ggg gcc gag gcc tgg ctt aag gcc aag cag ggg aag acc     1214
 Arg Gln Gln Gly Ala Glu Ala Trp Leu Lys Ala Lys Gln Gly Lys Thr
             290                 295                 300

 ttg gac ttt att gat gtg ctg ctc ctg gcc agg gat gaa gat gga aag     1262
 Leu Asp Phe Ile Asp Val Leu Leu Leu Ala Arg Asp Glu Asp Gly Lys
         305                 310                 315

 gaa ctg tca gac gag gat atc cga gcc gaa gca gac acc ttc atg ttt     1310
 Glu Leu Ser Asp Glu Asp Ile Arg Ala Glu Ala Asp Thr Phe Met Phe
     320                 325                 330

 gag ggt cac gac aca aca tcc agt ggg atc tct tgg atg ctg ttc aat     1358
 Glu Gly His Asp Thr Thr Ser Ser Gly Ile Ser Trp Met Leu Phe Asn
 335                 340                 345                 350

 ttg gca aag tat ccg gaa tac cag gag aaa tgc cga gaa gag att cag     1406
 Leu Ala Lys Tyr Pro Glu Tyr Gln Glu Lys Cys Arg Glu Glu Ile Gln
                 355                 360                 365

 gaa gtc atg aaa ggc cgg gag ctg gag gag ctg gag tgg tga gtgtggg     1455
 Glu Val Met Lys Gly Arg Glu Leu Glu Glu Leu Glu Trp 
             370                 375

 gtcaggggaa tggagggggc aggttgaggc cagagccttg ggtgtaagcc tctgctctcc   1515

 cacttattga ttgtgtgacc tcagacaagc cactttagct tcctgaattg caatttcttc   1575

 agctacaaaa tgggggtggg tatagtgcct atgcccacct cataatgcag aagttctcaa   1635

 agtgtcctag tcagcaatta ttgcaatggt gctgcataat gaacagctcc caaacttagt   1695

 ggtttacagc aagcatttgg ttcttgcttt tgtatgcaca catttcttgc tcttgtctgc   1755

 tcattactct aattgctgct ggacttggct gagtggagtg gaaatgcttt c            1806




      <210> 93
      <211> 3180
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (188)..(2986)

      <400> 93
 gcgctccgga attcccgggc atcattcagc ggcgccacgg agtcacacgt gctgcagatc     60

 ctgcagccag gtggagagtg cctcgttcac cgatggcagt gtcctcgacc cgacccagag    120

 cagattgtcc aactgctggc gcctctatgc ctggatccct ctgctcatat ttcccttctt    180

 actgtac  atg gtc ctg cct ccc agc ttg atg gtg gcc ggc gtg tac tgc     229
          Met Val Leu Pro Pro Ser Leu Met Val Ala Gly Val Tyr Cys
            1               5                  10

 ctc gtg gtg gct gtc atc ttt gct act atc aag act gtc aat tat cgg      277
 Leu Val Val Ala Val Ile Phe Ala Thr Ile Lys Thr Val Asn Tyr Arg
  15                  20                  25                  30

 ctt cat gcc atg ttt gac cag ggc gag atc gtg gag aag cgc agc tct      325
 Leu His Ala Met Phe Asp Gln Gly Glu Ile Val Glu Lys Arg Ser Ser
                  35                  40                  45

 acc atg ggg gag ctg gag gaa gag cct gcc cag ggg gac agc aat cca      373
 Thr Met Gly Glu Leu Glu Glu Glu Pro Ala Gln Gly Asp Ser Asn Pro
              50                  55                  60

 ccc agg gac ccc gga gtg gag atg aca gtg ttc cgg aaa gtc agt tcc      421
 Pro Arg Asp Pro Gly Val Glu Met Thr Val Phe Arg Lys Val Ser Ser
          65                  70                  75

 aca ccc ccg gtg cgc tgc agc tcc cag cac tct gtg ttt ggc ttc aac      469
 Thr Pro Pro Val Arg Cys Ser Ser Gln His Ser Val Phe Gly Phe Asn
      80                  85                  90

 cag gtc tcg gag ctg ctg ccc cga atg gag gac tct ggg ccc ctt aga      517
 Gln Val Ser Glu Leu Leu Pro Arg Met Glu Asp Ser Gly Pro Leu Arg
  95                 100                 105                 110

 gac atc aag gag ctg gtg cgg gag cag ggc agc aac aat gtg atc gtg      565
 Asp Ile Lys Glu Leu Val Arg Glu Gln Gly Ser Asn Asn Val Ile Val
                 115                 120                 125

 act tct gcc gac cga gag atg ctg aag ctc agc tcg cag gag aaa ctg      613
 Thr Ser Ala Asp Arg Glu Met Leu Lys Leu Ser Ser Gln Glu Lys Leu
             130                 135                 140

 att gga gac ctt ccc cag acg cct cca ggg gct gtc cca gac ccc tct      661
 Ile Gly Asp Leu Pro Gln Thr Pro Pro Gly Ala Val Pro Asp Pro Ser
         145                 150                 155

 ctt gcc agt aca gac tct tca gag cct tct ccc ctg gct gga gat gga      709
 Leu Ala Ser Thr Asp Ser Ser Glu Pro Ser Pro Leu Ala Gly Asp Gly
     160                 165                 170

 gcg ccc tgg agt ggg agc agc atg gct gac act ccc atg agc ccc ctg      757
 Ala Pro Trp Ser Gly Ser Ser Met Ala Asp Thr Pro Met Ser Pro Leu
 175                 180                 185                 190

 ctg aag ggg agc ctc agc cag gag ctg agc aag agc ttc ctg acc ctg      805
 Leu Lys Gly Ser Leu Ser Gln Glu Leu Ser Lys Ser Phe Leu Thr Leu
                 195                 200                 205

 acc cgg cct gac cgg gcc ctg gtg agg acc agc agt cga cgg gaa caa      853
 Thr Arg Pro Asp Arg Ala Leu Val Arg Thr Ser Ser Arg Arg Glu Gln
             210                 215                 220

 cgc agg ggg gca ggt ggc tat cag ccc ctt gac cgg cgg ggc tca ggg      901
 Arg Arg Gly Ala Gly Gly Tyr Gln Pro Leu Asp Arg Arg Gly Ser Gly
         225                 230                 235

 gag ccc acg ccc cag aaa gcc ggc tcc tca gac tcc tgc ttc agc ggc      949
 Glu Pro Thr Pro Gln Lys Ala Gly Ser Ser Asp Ser Cys Phe Ser Gly
     240                 245                 250

 act gac agg gag aca ttg agc agc ttc aag agt gag aag acc aac tcc      997
 Thr Asp Arg Glu Thr Leu Ser Ser Phe Lys Ser Glu Lys Thr Asn Ser
 255                 260                 265                 270

 acc cat ctg gac agc ccc cca ggg ggg cca gcc cct gag ggc agc gac     1045
 Thr His Leu Asp Ser Pro Pro Gly Gly Pro Ala Pro Glu Gly Ser Asp
                 275                 280                 285

 aca gac cca ccc tct gag gct gag ctg cct gcc tca cca gac gcc ggg     1093
 Thr Asp Pro Pro Ser Glu Ala Glu Leu Pro Ala Ser Pro Asp Ala Gly
             290                 295                 300

 gtc ccc tca gat gac acg ctg cgt tcc ttt gac acg gtc att gga gca     1141
 Val Pro Ser Asp Asp Thr Leu Arg Ser Phe Asp Thr Val Ile Gly Ala
         305                 310                 315

 ggg acg cca ccg ggc ctg gct gag ccg ctc ctg gtc gtg cgg ccc aag     1189
 Gly Thr Pro Pro Gly Leu Ala Glu Pro Leu Leu Val Val Arg Pro Lys
     320                 325                 330

 gac ttg gcc ctg cta cgg cct agc aaa cgg cag cca ccc ctg cga aga     1237
 Asp Leu Ala Leu Leu Arg Pro Ser Lys Arg Gln Pro Pro Leu Arg Arg
 335                 340                 345                 350

 cac tct cca cct ggc cgt gcc cct cga cgg ccc ctg ctt gaa ggt ggg     1285
 His Ser Pro Pro Gly Arg Ala Pro Arg Arg Pro Leu Leu Glu Gly Gly
                 355                 360                 365

 ggc ttc ttt gag gat gaa gac act agt gag ggc agt gaa ctg agc ccg     1333
 Gly Phe Phe Glu Asp Glu Asp Thr Ser Glu Gly Ser Glu Leu Ser Pro
             370                 375                 380

 gcc tcc agt ctc cga tcg cag cgc cgc tac agt act gac agc tcc tct     1381
 Ala Ser Ser Leu Arg Ser Gln Arg Arg Tyr Ser Thr Asp Ser Ser Ser
         385                 390                 395

 tct act tcc tgc tac tcc cct gag agc tcc cgg ggt gca gca ggg gga     1429
 Ser Thr Ser Cys Tyr Ser Pro Glu Ser Ser Arg Gly Ala Ala Gly Gly
     400                 405                 410

 ccc cgg aag cgg agg gcc ccc cat ggg gct gag gag gga act gct gtg     1477
 Pro Arg Lys Arg Arg Ala Pro His Gly Ala Glu Glu Gly Thr Ala Val
 415                 420                 425                 430

 ccc ccc aag cgg cca tat ggg acc cag cgg acg cct agt acc gcc agc     1525
 Pro Pro Lys Arg Pro Tyr Gly Thr Gln Arg Thr Pro Ser Thr Ala Ser
                 435                 440                 445

 gct aaa aca cat gcc cgt gtg ctg agc atg gat ggg gct ggg ggt gat     1573
 Ala Lys Thr His Ala Arg Val Leu Ser Met Asp Gly Ala Gly Gly Asp
             450                 455                 460

 gtt ctg agg ccc cca ctg gct ggc tgc aag gca gag ctg gag gcc cag     1621
 Val Leu Arg Pro Pro Leu Ala Gly Cys Lys Ala Glu Leu Glu Ala Gln
         465                 470                 475

 gtt ggg gtg gag cag gct gct agt gag cct gtt gtg ctg cct gct gag     1669
 Val Gly Val Glu Gln Ala Ala Ser Glu Pro Val Val Leu Pro Ala Glu
     480                 485                 490

 gcg cga agg gga ccc gct gcc aac cag ccc ggc tgg cgg ggg gag ctg     1717
 Ala Arg Arg Gly Pro Ala Ala Asn Gln Pro Gly Trp Arg Gly Glu Leu
 495                 500                 505                 510

 cag gag gaa ggt gct gtg ggg gga gcg gcc gag gag act ggc agg cgg     1765
 Gln Glu Glu Gly Ala Val Gly Gly Ala Ala Glu Glu Thr Gly Arg Arg
                 515                 520                 525

 gac cgc tca agc agt gtg agg cgg acc cag gcc att cgg aga cgc cac     1813
 Asp Arg Ser Ser Ser Val Arg Arg Thr Gln Ala Ile Arg Arg Arg His
             530                 535                 540

 aat gca ggc agc aac ccc acc cct cca gcc tct gtc atg ggc tcg ccg     1861
 Asn Ala Gly Ser Asn Pro Thr Pro Pro Ala Ser Val Met Gly Ser Pro
         545                 550                 555

 ccc agc agc ctg cag gaa gct cag cgg ggc cgg gct gcc tcc cac tcc     1909
 Pro Ser Ser Leu Gln Glu Ala Gln Arg Gly Arg Ala Ala Ser His Ser
     560                 565                 570

 cgg gcg ctg acg ctg ccc tct gcg ctg cat ttc gcc tct tca ctg ttg     1957
 Arg Ala Leu Thr Leu Pro Ser Ala Leu His Phe Ala Ser Ser Leu Leu
 575                 580                 585                 590

 ctc acc cgg gcc ggt gcc aat gtg cat gag gcc tgc acc ttt gat gac     2005
 Leu Thr Arg Ala Gly Ala Asn Val His Glu Ala Cys Thr Phe Asp Asp
                 595                 600                 605

 act tct gag ggt gca gtg cac tat ttc tac gat gag agc ggt gtg cgg     2053
 Thr Ser Glu Gly Ala Val His Tyr Phe Tyr Asp Glu Ser Gly Val Arg
             610                 615                 620

 cgt tcc tac acc ttt ggc ctg gct gga ggc ggc tac gag aac cct gta     2101
 Arg Ser Tyr Thr Phe Gly Leu Ala Gly Gly Gly Tyr Glu Asn Pro Val
         625                 630                 635

 ggg cag caa ggg gag cag aca gct aat gga gcc tgg gac cga cac tcg     2149
 Gly Gln Gln Gly Glu Gln Thr Ala Asn Gly Ala Trp Asp Arg His Ser
     640                 645                 650

 cat tcc tcc agc ttc cac tcg gct gat gtc cct gag gct aca ggc ggc     2197
 His Ser Ser Ser Phe His Ser Ala Asp Val Pro Glu Ala Thr Gly Gly
 655                 660                 665                 670

 ctg aac ctg ctg cag ccg agg cct gtg gtt ctg cag ggc atg cag gtg     2245
 Leu Asn Leu Leu Gln Pro Arg Pro Val Val Leu Gln Gly Met Gln Val
                 675                 680                 685

 cgc cgg gtg ccc ctg gag atc ccg gag gag cag aca ctg atg gaa gaa     2293
 Arg Arg Val Pro Leu Glu Ile Pro Glu Glu Gln Thr Leu Met Glu Glu
             690                 695                 700

 gcg cca ccc cgg gcc cag cat agt tac aag tac tgg ctt ctc cct ggc     2341
 Ala Pro Pro Arg Ala Gln His Ser Tyr Lys Tyr Trp Leu Leu Pro Gly
         705                 710                 715

 cgc tgg acc tct gtg cgc tat gag cgg ctt gcc ctg ctg gct ctg ctg     2389
 Arg Trp Thr Ser Val Arg Tyr Glu Arg Leu Ala Leu Leu Ala Leu Leu
     720                 725                 730

 gac cgg acg cgg gga gtg ctg gag aac atc ttc ggc gtg ggc ctg agc     2437
 Asp Arg Thr Arg Gly Val Leu Glu Asn Ile Phe Gly Val Gly Leu Ser
 735                 740                 745                 750

 agc ctt gtg gcc ttc ctg ggc tac ctg ctg ctg ctc aag ggc ttc ttc     2485
 Ser Leu Val Ala Phe Leu Gly Tyr Leu Leu Leu Leu Lys Gly Phe Phe
                 755                 760                 765

 act gac atc tgg gtc ttc cag ttc tgc ctg gtc atc gcc tcc tgc cag     2533
 Thr Asp Ile Trp Val Phe Gln Phe Cys Leu Val Ile Ala Ser Cys Gln
             770                 775                 780

 tac tcc ttg ctg aag agc gtg cag cct gat gcg gcg tcc ccc atg cac     2581
 Tyr Ser Leu Leu Lys Ser Val Gln Pro Asp Ala Ala Ser Pro Met His
         785                 790                 795

 ggc cac aac tgg gtg atc gcg tac agc cgt cct gtc tac ttc tgc atc     2629
 Gly His Asn Trp Val Ile Ala Tyr Ser Arg Pro Val Tyr Phe Cys Ile
     800                 805                 810

 tgc tgt ctg ctc atc tgg ctg ctg gac gcc ctg ggc tca gct cag ccc     2677
 Cys Cys Leu Leu Ile Trp Leu Leu Asp Ala Leu Gly Ser Ala Gln Pro
 815                 820                 825                 830

 ttc cca cct gtc tcc ctc tac ggc ctc acg ctc ttc tct gcc tcc ttc     2725
 Phe Pro Pro Val Ser Leu Tyr Gly Leu Thr Leu Phe Ser Ala Ser Phe
                 835                 840                 845

 ttc ttc tgt gcc cga gac gtg gcc act gtg ttc acc ctg tgc ttc ccc     2773
 Phe Phe Cys Ala Arg Asp Val Ala Thr Val Phe Thr Leu Cys Phe Pro
             850                 855                 860

 ttc gtc ttc ctc ctg ggc ctc ctg ccc cag gtc aac acc tgc ccc aga     2821
 Phe Val Phe Leu Leu Gly Leu Leu Pro Gln Val Asn Thr Cys Pro Arg
         865                 870                 875

 ccc agg agc ccc cct gag gct ttg cct tgc ctg cat att tgt ttc gct     2869
 Pro Arg Ser Pro Pro Glu Ala Leu Pro Cys Leu His Ile Cys Phe Ala
     880                 885                 890

 ctt act cag ttt ggg aat tca aat tgt cct gca gag gtt cat tcc cct     2917
 Leu Thr Gln Phe Gly Asn Ser Asn Cys Pro Ala Glu Val His Ser Pro
 895                 900                 905                 910

 gac cct ttc ccc aca ttg gta aga gta gct ggg ttt tct aag cca ctc     2965
 Asp Pro Phe Pro Thr Leu Val Arg Val Ala Gly Phe Ser Lys Pro Leu
                 915                 920                 925

 tct gga atc tct ttg tgt tag gg tctcgatttg aggacattca tttcttcagc     3018
 Ser Gly Ile Ser Leu Cys 
             930

 agcccattag caactgagag cccagggatg tcctacagga tagtttcata gtgacaggtg   3078

 gcacttggct aatagaatat ggctgatatt gtcattaatc attttgtacc ttgacatggg   3138

 ttgtctaata aaactcggac ccttcttgtg aaatcagtta aa                      3180




      <210> 94
      <211> 962
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (241)..(921)

      <400> 94
 aggacctcac cccgcgcgtg ttccccgggc gcccctctgc gaaccccagg cccttcccag     60

 gtttgcgcgc gggggccatc cagaccctgc ggagagcgag gcccggagcg tcgccgaggt    120

 ttgagggcgc cggagaccga gggcctggcg gccgaaggaa ccgccccaag aagagcctct    180

 ggcccggggg ctgctggaac atgtgcgggg ggacacagtt tgtttgacag ttgccagact    240
                                                                 
 atg ttt acg ctt ctg gtt cta ctc agc caa ctg ccc aca gtt acc ctg      288
 Met Phe Thr Leu Leu Val Leu Leu Ser Gln Leu Pro Thr Val Thr Leu
   1               5                  10                  15

 ggg ttt cct cat tgc gca aga ggt cca aag gct tct aag cat gcg gga      336
 Gly Phe Pro His Cys Ala Arg Gly Pro Lys Ala Ser Lys His Ala Gly
              20                  25                  30

 gaa gaa gtg ttt aca tca aaa gaa gaa gca aac ttt ttc ata cat aga      384
 Glu Glu Val Phe Thr Ser Lys Glu Glu Ala Asn Phe Phe Ile His Arg
          35                  40                  45

 cgc ctt ctg tat aat aga ttt gat ctg gag ctc ttc act ccc ggc aac      432
 Arg Leu Leu Tyr Asn Arg Phe Asp Leu Glu Leu Phe Thr Pro Gly Asn
      50                  55                  60

 cta gaa aga gag tgc aat gaa gaa ctt tgc aat tat gag gaa gcc aga      480
 Leu Glu Arg Glu Cys Asn Glu Glu Leu Cys Asn Tyr Glu Glu Ala Arg
  65                  70                  75                  80

 gag att ttt gtg gat gaa gat aaa acg att gca ttt tgg cag gaa tat      528
 Glu Ile Phe Val Asp Glu Asp Lys Thr Ile Ala Phe Trp Gln Glu Tyr
                  85                  90                  95

 tca gct aaa gga cca acc aca aaa tca gat ggc aac aga gag aaa ata      576
 Ser Ala Lys Gly Pro Thr Thr Lys Ser Asp Gly Asn Arg Glu Lys Ile
             100                 105                 110

 gat gtt atg ggc ctt ctg act gga tta att gct gct gga gta ttt ttg      624
 Asp Val Met Gly Leu Leu Thr Gly Leu Ile Ala Ala Gly Val Phe Leu
         115                 120                 125

 gtt att ttt gga tta ctt ggc tac tat ctt tgt atc act aag tgt aat      672
 Val Ile Phe Gly Leu Leu Gly Tyr Tyr Leu Cys Ile Thr Lys Cys Asn
     130                 135                 140

 agg cta caa cat cca tgc tct tca gcc gtc tat gaa agg ggg agg cac      720
 Arg Leu Gln His Pro Cys Ser Ser Ala Val Tyr Glu Arg Gly Arg His
 145                 150                 155                 160

 act ccc tcc atc att ttc aga aga cct gag gag gct gcc ttg tct cca      768
 Thr Pro Ser Ile Ile Phe Arg Arg Pro Glu Glu Ala Ala Leu Ser Pro
                 165                 170                 175

 ttg ccg cct tct gtg gag gat gca gga tta cct tct tat gaa cag gca      816
 Leu Pro Pro Ser Val Glu Asp Ala Gly Leu Pro Ser Tyr Glu Gln Ala
             180                 185                 190

 gtg gcg ctg acc aga aaa cac agt gtt tca cca cca cca cca tat cct      864
 Val Ala Leu Thr Arg Lys His Ser Val Ser Pro Pro Pro Pro Tyr Pro
         195                 200                 205

 ggg cac aca aaa gga ttt agg gta ttt aaa aaa tct atg tct ctc cca      912
 Gly His Thr Lys Gly Phe Arg Val Phe Lys Lys Ser Met Ser Leu Pro
     210                 215                 220

 tct cac tga ctaccttgtc attttggtat aagaaatttg tgttatttga t            962
 Ser His 
 225





      <210> 95
      <211> 1375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (126)..(1325)

      <400> 95
 agcggcgcgc gaggccccca ccgtcgccga cgcccgagcg ccggagcccc ggccccgccc     60

 cgcgagcgcc gagacttgtt ggccgcggag actgcgaccc tcttctctca gtctgcctta    120

 ctacc    atg ccg ctc tac gag ggc ctg ggg agc ggc ggg gag aag acg     167
          Met Pro Leu Tyr Glu Gly Leu Gly Ser Gly Gly Glu Lys Thr
            1               5                  10

 gcg gtc gtg atc gac ctg gga gag gcc ttt acc aag tgt gga ttt gct      215
 Ala Val Val Ile Asp Leu Gly Glu Ala Phe Thr Lys Cys Gly Phe Ala
  15                  20                  25                  30

 gga gaa act ggt cca aga tgt ata att cct agt gtg ata gaa gaa tta      263
 Gly Glu Thr Gly Pro Arg Cys Ile Ile Pro Ser Val Ile Glu Glu Leu
                  35                  40                  45

 tat tcc tac cta aag gaa ttc atc cac ata cta tat ttc agg cat cta      311
 Tyr Ser Tyr Leu Lys Glu Phe Ile His Ile Leu Tyr Phe Arg His Leu
              50                  55                  60

 ttg gtg aat ccc aga gac cgc cga gtt gtg att atc gaa tcg gta tta      359
 Leu Val Asn Pro Arg Asp Arg Arg Val Val Ile Ile Glu Ser Val Leu
          65                  70                  75

 tgt cct tct cac ttc aga gag aca ctc act cgt gtt ctt ttc aaa tat      407
 Cys Pro Ser His Phe Arg Glu Thr Leu Thr Arg Val Leu Phe Lys Tyr
      80                  85                  90

 ttt gag gtt cca tct gtc ttg ctt gct cca agt cat cta atg gct ctt      455
 Phe Glu Val Pro Ser Val Leu Leu Ala Pro Ser His Leu Met Ala Leu
  95                 100                 105                 110

 ctg acg ctt gga att aat tct gcc atg gtc cta gat tgt gga tat agg      503
 Leu Thr Leu Gly Ile Asn Ser Ala Met Val Leu Asp Cys Gly Tyr Arg
                 115                 120                 125

 gaa agc ctg gtg tta ccc ata tat gaa gga atc cca gtt cta aat tgt      551
 Glu Ser Leu Val Leu Pro Ile Tyr Glu Gly Ile Pro Val Leu Asn Cys
             130                 135                 140

 tgg gga gca cta ccc cta gga gga aaa gct ctt cac aaa gag ttg gaa      599
 Trp Gly Ala Leu Pro Leu Gly Gly Lys Ala Leu His Lys Glu Leu Glu
         145                 150                 155

 act caa cta ttg gaa caa tgt act gtt gac aca agt gtt gct aaa gaa      647
 Thr Gln Leu Leu Glu Gln Cys Thr Val Asp Thr Ser Val Ala Lys Glu
     160                 165                 170

 cag agc ctt ccc tca gtg atg ggt tca gtt ccg gaa ggt gtc tta gag      695
 Gln Ser Leu Pro Ser Val Met Gly Ser Val Pro Glu Gly Val Leu Glu
 175                 180                 185                 190

 gac att aaa gcg cgt act tgc ttt gta agt gat ctg aag cga gga cta      743
 Asp Ile Lys Ala Arg Thr Cys Phe Val Ser Asp Leu Lys Arg Gly Leu
                 195                 200                 205

 aaa atc caa gca gca aaa ttt aat att gat ggg aat aat gag cgt ccc      791
 Lys Ile Gln Ala Ala Lys Phe Asn Ile Asp Gly Asn Asn Glu Arg Pro
             210                 215                 220

 tcc cca ccc cca aat gtt gac tat cca tta gat gga gag aag att tta      839
 Ser Pro Pro Pro Asn Val Asp Tyr Pro Leu Asp Gly Glu Lys Ile Leu
         225                 230                 235

 cat atc ctt gga tca atc aga gat tca gtt gtg gaa att ctt ttt gaa      887
 His Ile Leu Gly Ser Ile Arg Asp Ser Val Val Glu Ile Leu Phe Glu
     240                 245                 250

 caa gat aat gaa gag caa tca gtt gcc act tta ata ttg gat tcc ctt      935
 Gln Asp Asn Glu Glu Gln Ser Val Ala Thr Leu Ile Leu Asp Ser Leu
 255                 260                 265                 270

 ata cag tgt ccg ata gac acc agg aag caa cta gca gag aat ttg gta      983
 Ile Gln Cys Pro Ile Asp Thr Arg Lys Gln Leu Ala Glu Asn Leu Val
                 275                 280                 285

 gtc ata ggt ggc act tct atg ttg cca gga ttt ctc cac aga ttg ctt     1031
 Val Ile Gly Gly Thr Ser Met Leu Pro Gly Phe Leu His Arg Leu Leu
             290                 295                 300

 gca gaa ata agg tat ttg gta gaa aaa cca aaa tat aaa aaa gca ctt     1079
 Ala Glu Ile Arg Tyr Leu Val Glu Lys Pro Lys Tyr Lys Lys Ala Leu
         305                 310                 315

 ggc act aag aca ttt cga att cat act cca cct gca aaa gct aat tgt     1127
 Gly Thr Lys Thr Phe Arg Ile His Thr Pro Pro Ala Lys Ala Asn Cys
     320                 325                 330

 gtg gcc tgg ttg gga ggg gct att ttt gga gca tta caa gat ata ctt     1175
 Val Ala Trp Leu Gly Gly Ala Ile Phe Gly Ala Leu Gln Asp Ile Leu
 335                 340                 345                 350

 ggg agc cgt tct gtt tca aag gaa tat tat aat cag acg ggc cgt ata     1223
 Gly Ser Arg Ser Val Ser Lys Glu Tyr Tyr Asn Gln Thr Gly Arg Ile
                 355                 360                 365

 cct gat tgg tgt tct ctc aat aac cca cct ttg gaa atg atg ttt gat     1271
 Pro Asp Trp Cys Ser Leu Asn Asn Pro Pro Leu Glu Met Met Phe Asp
             370                 375                 380

 gtc ggg aaa act caa cca cct ctg atg aag aga gca ttt tcc act gag     1319
 Val Gly Lys Thr Gln Pro Pro Leu Met Lys Arg Ala Phe Ser Thr Glu
         385                 390                 395

 aaa tag aagtttgatt aaaaatcaac cttgcttcat atcaaatatt taaccaatta      1375
 Lys 






      <210> 96
      <211> 2641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (334)..(1968)

      <400> 96
 tgccatggct tatgggatga agatgacatg actgaaagtg gcatggccag ggaggaatca     60

 gatgatgagc tctccctcgg tcatggcagg agggactcct ccgattctct caagtccatc    120

 aacctggccg cgtctgtgga gtcagtgcat gtgaccttcc cggagcagca gacagctgtc    180

 cggaggaagc gctccggcag cagctccgag ccatcccaga gatccagctt ttcttcaaac    240

 agatcccaaa gaggcagcac aagcacccga aacagcagtc aaaaaggaag cagtgttttg    300

 agtattaagc aaaaaggcaa aagggaactt tat atg gaa aag ctt caa gaa cat     354
                                      Met Glu Lys Leu Gln Glu His
                                        1               5

 tta atc aaa gca aaa gcc ttt acc ata aag aag acg ctg gag atc tat      402
 Leu Ile Lys Ala Lys Ala Phe Thr Ile Lys Lys Thr Leu Glu Ile Tyr
          10                  15                  20

 gtg ccc atc aaa cag ttc ttt tac aac ctc atc cac ccg gag tat agc      450
 Val Pro Ile Lys Gln Phe Phe Tyr Asn Leu Ile His Pro Glu Tyr Ser
      25                  30                  35

 gcc gtg act gac gtg tat gta ctc atg ttc ctg gct gac act gtg gac      498
 Ala Val Thr Asp Val Tyr Val Leu Met Phe Leu Ala Asp Thr Val Asp
  40                  45                  50                  55

 ttc atc atc att gtc ttc ggc ttt tgg gcc ttt ggg aaa cac tca gca      546
 Phe Ile Ile Ile Val Phe Gly Phe Trp Ala Phe Gly Lys His Ser Ala
                  60                  65                  70

 gct gca gac atc acc tct tca ctg tca gag gac cag gtc ccg ggg ccg      594
 Ala Ala Asp Ile Thr Ser Ser Leu Ser Glu Asp Gln Val Pro Gly Pro
              75                  80                  85

 ttt ttg gtg atg gtc ctc att cag ttt gga acc atg gtg gtg gac cga      642
 Phe Leu Val Met Val Leu Ile Gln Phe Gly Thr Met Val Val Asp Arg
          90                  95                 100

 gcc ctc tac ctc agg aag act gta ctg gga aag gtc atc ttc cag gtc      690
 Ala Leu Tyr Leu Arg Lys Thr Val Leu Gly Lys Val Ile Phe Gln Val
     105                 110                 115

 att ctt gtg ttc gga att cac ttc tgg atg ttc ttc atc tta cct ggt      738
 Ile Leu Val Phe Gly Ile His Phe Trp Met Phe Phe Ile Leu Pro Gly
 120                 125                 130                 135

 gtg act gag agg aaa ttc agc cag aac ctg gtt gcc cag ctt tgg tac      786
 Val Thr Glu Arg Lys Phe Ser Gln Asn Leu Val Ala Gln Leu Trp Tyr
                 140                 145                 150

 ttt gtg aaa tgt gtt tac ttc ggg ttg tct gct tac cag atc cgt tgt      834
 Phe Val Lys Cys Val Tyr Phe Gly Leu Ser Ala Tyr Gln Ile Arg Cys
             155                 160                 165

 ggc tac cca acg cga gtc ctg ggg aac ttc ctc acc aag agc tac aat      882
 Gly Tyr Pro Thr Arg Val Leu Gly Asn Phe Leu Thr Lys Ser Tyr Asn
         170                 175                 180

 tac gtc aac ctc ttc tta ttc caa ggg ttt cgc ctc gtg ccc ttt ttg      930
 Tyr Val Asn Leu Phe Leu Phe Gln Gly Phe Arg Leu Val Pro Phe Leu
     185                 190                 195

 act gag ctg agg gca gtg atg gac tgg gtg tgg acg gac aca act ttg      978
 Thr Glu Leu Arg Ala Val Met Asp Trp Val Trp Thr Asp Thr Thr Leu
 200                 205                 210                 215

 agc ctg tcc agc tgg atc tgt gtg gag gac atc tat gct cac ata ttc     1026
 Ser Leu Ser Ser Trp Ile Cys Val Glu Asp Ile Tyr Ala His Ile Phe
                 220                 225                 230

 atc ctg aag tgt tgg cgg gag tcg gag aag cct att ttc aca atg agt     1074
 Ile Leu Lys Cys Trp Arg Glu Ser Glu Lys Pro Ile Phe Thr Met Ser
             235                 240                 245

 gcc caa caa agc cag ttg aaa gtt atg gac cag cag agc ttt aac aaa     1122
 Ala Gln Gln Ser Gln Leu Lys Val Met Asp Gln Gln Ser Phe Asn Lys
         250                 255                 260

 ttt ata caa gct ttt tct agg gac acc ggt gct atg caa ttt ctg gaa     1170
 Phe Ile Gln Ala Phe Ser Arg Asp Thr Gly Ala Met Gln Phe Leu Glu
     265                 270                 275

 aat tat gaa aaa gaa gac ata aca gta gca gaa ctg gaa gga aac tca     1218
 Asn Tyr Glu Lys Glu Asp Ile Thr Val Ala Glu Leu Glu Gly Asn Ser
 280                 285                 290                 295

 aat tct ttg tgg acc atc agc cca ccc agt aag cag aaa atg ata cac     1266
 Asn Ser Leu Trp Thr Ile Ser Pro Pro Ser Lys Gln Lys Met Ile His
                 300                 305                 310

 gaa ctc ctg gac ccc aat agt agc ttc tct gtt gtt ttt tca tgg agt     1314
 Glu Leu Leu Asp Pro Asn Ser Ser Phe Ser Val Val Phe Ser Trp Ser
             315                 320                 325

 att cag aga aac tta agt ctg ggt gca aaa tcg gaa ata gca aca gat     1362
 Ile Gln Arg Asn Leu Ser Leu Gly Ala Lys Ser Glu Ile Ala Thr Asp
         330                 335                 340

 aag ctt tct ttt cct ctt aaa aat att act cga aag aat atc gct aaa     1410
 Lys Leu Ser Phe Pro Leu Lys Asn Ile Thr Arg Lys Asn Ile Ala Lys
     345                 350                 355

 atg ata gca ggc aac agc aca gaa agt tca aaa aca cca gtg acc ata     1458
 Met Ile Ala Gly Asn Ser Thr Glu Ser Ser Lys Thr Pro Val Thr Ile
 360                 365                 370                 375

 gaa aag att tat cca tat tat gtg aaa gca cct agt gat tct aac tca     1506
 Glu Lys Ile Tyr Pro Tyr Tyr Val Lys Ala Pro Ser Asp Ser Asn Ser
                 380                 385                 390

 aaa cct ata aag caa ctt tta tct gaa aat aat ttc atg gat att acc     1554
 Lys Pro Ile Lys Gln Leu Leu Ser Glu Asn Asn Phe Met Asp Ile Thr
             395                 400                 405

 atc att ttg tcc aga gac aat aca act aaa tat aac agt gag tgg tgg     1602
 Ile Ile Leu Ser Arg Asp Asn Thr Thr Lys Tyr Asn Ser Glu Trp Trp
         410                 415                 420

 gtt ctc aac ctg act gga aac aga ata tac aat ccg aac tct cag gcc     1650
 Val Leu Asn Leu Thr Gly Asn Arg Ile Tyr Asn Pro Asn Ser Gln Ala
     425                 430                 435

 ctg gaa ctg gtg gtc ttc aat gac aaa gtc agt ccc cca agt ctg ggg     1698
 Leu Glu Leu Val Val Phe Asn Asp Lys Val Ser Pro Pro Ser Leu Gly
 440                 445                 450                 455

 ttc ctg gct ggc tat ggt att atg gga tta tat gct tca gtt gtc ctt     1746
 Phe Leu Ala Gly Tyr Gly Ile Met Gly Leu Tyr Ala Ser Val Val Leu
                 460                 465                 470

 gtg att ggg aaa ttt gtc cgt gaa ttc ttc agt ggg att tct cac tcc     1794
 Val Ile Gly Lys Phe Val Arg Glu Phe Phe Ser Gly Ile Ser His Ser
             475                 480                 485

 atc atg ttt gaa gag ctt cca aat gtg gat cga att ttg aag ttg tgc     1842
 Ile Met Phe Glu Glu Leu Pro Asn Val Asp Arg Ile Leu Lys Leu Cys
         490                 495                 500

 aca gat att ttt tta gtt cga gag aca gga gaa ctg gag cta gaa gaa     1890
 Thr Asp Ile Phe Leu Val Arg Glu Thr Gly Glu Leu Glu Leu Glu Glu
     505                 510                 515

 gat ctc tat gcc aaa tta ata ttc cta tat cgc tca cca gag aca atg     1938
 Asp Leu Tyr Ala Lys Leu Ile Phe Leu Tyr Arg Ser Pro Glu Thr Met
 520                 525                 530                 535

 atc aaa tgg act aga gaa aaa aca aat tga a accttagaac acagactgca     1989
 Ile Lys Trp Thr Arg Glu Lys Thr Asn 
                 540

 aataatgtta acatttgaat tttttttaaa agcacaatat tctcataaga gctaagcatt   2049

 tctagttcga cggaaatggt ttgtttctct tctgataggt agacaaaagg agctgatatc   2109

 cttctgcagt aaaagctacc ttgcaagtta aggcactgtt gaaaatgtta tttgtaactc   2169

 catttctctg aaatcagggc tacttgcttt atgttttagt caacagtgtc tcgcattctg   2229

 attgatcatg tgaaggaatc atttatgggc cccgtcccta agagaaacag aagaggagtc   2289

 agaaagaaag atgcctgtgt tttcctctgt ggggcccgtg cacttcctgg agagatgcta   2349

 caatgcaata tacagcgctc catccccact ggggaagctg ctgtgatgag actagatgag   2409

 ccttcaacac actcagaaaa tgcaacagca atagggggca gacagctcct acctgtgttt   2469

 ctaggagcaa aagagaggga actaattgcc cgtgaagacg ccagtggaag gatcagcctc   2529

 attctaagca aaaacatagt attagtgata ctcttactgc cttatcttaa ccaaggacta   2589

 ataggatacc tttccattaa acaccagtga cttctcagga aaaaaaaaaa aa           2641




      <210> 97
      <211> 1329
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(800)

      <400> 97
 caggaactca aatacacagg aaacagttgt ttcacgtgtc ggactccttt ccattgctct     60

 ttccaatgtg gtaatgcagc taaactaaga gaaaagcc    atg gag act tca gca     113
                                              Met Glu Thr Ser Ala
                                                1               5

 tcc tcc tcc cag cct cag gac aac agt caa gtc cac aga gaa aca gaa      161
 Ser Ser Ser Gln Pro Gln Asp Asn Ser Gln Val His Arg Glu Thr Glu
                  10                  15                  20

 gat gta gac tat gga gag aca gat ttc cac aag caa gat ggg aag gct      209
 Asp Val Asp Tyr Gly Glu Thr Asp Phe His Lys Gln Asp Gly Lys Ala
              25                  30                  35

 gga ctc ttt tcc caa gaa caa tat gag aga aac aag tct tct tcc tcc      257
 Gly Leu Phe Ser Gln Glu Gln Tyr Glu Arg Asn Lys Ser Ser Ser Ser
          40                  45                  50

 tcc ttc tct tcc tcc tca tcc tcc tca tct tct tca tcc tcc tcc tcc      305
 Ser Phe Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
      55                  60                  65

 tca gag agc aat gat gag gac cag caa ccc aga gca acc gga aaa cat      353
 Ser Glu Ser Asn Asp Glu Asp Gln Gln Pro Arg Ala Thr Gly Lys His
  70                  75                  80                  85

 cga cgg agc ctg ggg gct gga tac ccc cac ggg aac ggc tca ccc ggt      401
 Arg Arg Ser Leu Gly Ala Gly Tyr Pro His Gly Asn Gly Ser Pro Gly
                  90                  95                 100

 cct ggg cat ggg gag cct gac gtt ttg aag gat gag ctt caa ctc tat      449
 Pro Gly His Gly Glu Pro Asp Val Leu Lys Asp Glu Leu Gln Leu Tyr
             105                 110                 115

 gga gat gct cct gga gag gtg gta ccc tct ggg gaa tca gga ctc cga      497
 Gly Asp Ala Pro Gly Glu Val Val Pro Ser Gly Glu Ser Gly Leu Arg
         120                 125                 130

 agg aga ggc tct gac cca gca agt gga gaa gtg gag gcc tct cag tta      545
 Arg Arg Gly Ser Asp Pro Ala Ser Gly Glu Val Glu Ala Ser Gln Leu
     135                 140                 145

 aga aga ctg aat ata aag aaa gat gat gag ttt ttc cat ttc gtc ctc      593
 Arg Arg Leu Asn Ile Lys Lys Asp Asp Glu Phe Phe His Phe Val Leu
 150                 155                 160                 165

 ctg tgc ttt gcc atc ggg gcc ttg ctg gtg tgt tat cac tat tac gca      641
 Leu Cys Phe Ala Ile Gly Ala Leu Leu Val Cys Tyr His Tyr Tyr Ala
                 170                 175                 180

 gac tgg ttc atg tct ctt ggg gtc ggc ctg ctc acc ttc gcc tcc ctg      689
 Asp Trp Phe Met Ser Leu Gly Val Gly Leu Leu Thr Phe Ala Ser Leu
             185                 190                 195

 gaa acc gtt ggc atc tac ttc gga cta gtg tac cgt atc cac agc gtc      737
 Glu Thr Val Gly Ile Tyr Phe Gly Leu Val Tyr Arg Ile His Ser Val
         200                 205                 210

 ctc caa ggc ttc atc ccc ctc ttc cag aag ttt agg ctg aca ggg ttc      785
 Leu Gln Gly Phe Ile Pro Leu Phe Gln Lys Phe Arg Leu Thr Gly Phe
     215                 220                 225

 agg aag act gac tga ggccacttcc aggtgggcag cagaggcagg ccccagtgtg      840
 Arg Lys Thr Asp 
 230

 accaccactg cgacccctga gcccacaagg gcagagcagc attctgagag acgcacagga    900

 gaccaagcca gaccaataaa cagaacactt ttccttccat gtggtctgaa tgttggcacc    960

 agcccgggca ggggcatctc atttgggcag tactgctgtg caacccagct gcaaggatgg   1020

 aaggcagagg gtgggtgtgg ggcctgaggc ttcacagtac ctggaccagc aggaagattc   1080

 tgggaggtca ctgctctcag aggacagcaa gggaccctga gctctgcaag ctgtgatctg   1140

 tctgggttca tggtttttct caaatcccag gctatctgca tgcgctctca ggtgctaccg   1200

 agccatcctg ggagagatgg atggtccact gctttgaggc agggagccat cgggctgggg   1260

 ccccttggtg aacctgatgc aggtaagatg ctgaggacta aaaccatttt ttttgcaccc   1320

 aaaaaaaaa                                                           1329




      <210> 98
      <211> 674
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (250)..(558)

      <400> 98
 atggagcaga aaatgtgctc ccttatttct gggaaccaac tacaaggaac acatgttcag     60

 tatgtaattg tgtatggcct ccagttcagg ggagcacacg gcagaattcc taccccaact    120

 ttgggagctg tgatacacag agccatgaac agacagggca gacggggtgg ggagcttatg    180

 ataagggatc caagaggaat agagggtgaa ggaaatggcc atgaaggatt caggcggctc    240

 gggatcgag    atg acc aca gcc acc cct ctg ggg gat acc acc ttc ttc     288
              Met Thr Thr Ala Thr Pro Leu Gly Asp Thr Thr Phe Phe
                1               5                  10

 tca ctg aac atg acc acc agg gga gaa gac ttc ctg tat aag agt tct      336
 Ser Leu Asn Met Thr Thr Arg Gly Glu Asp Phe Leu Tyr Lys Ser Ser
      15                  20                  25

 gga gcc att gtt gct gcc gtt gtg gtg gtt gtc atc atc atc ttc acc      384
 Gly Ala Ile Val Ala Ala Val Val Val Val Val Ile Ile Ile Phe Thr
  30                  35                  40                  45

 gtg gtt ctg atc ctg ctg aag atg tac aac agg aaa atg agg acg agg      432
 Val Val Leu Ile Leu Leu Lys Met Tyr Asn Arg Lys Met Arg Thr Arg
                  50                  55                  60

 cgg gaa cta gag ccc aag ggc ccc aag cca acc gcc cct tct gcc gtg      480
 Arg Glu Leu Glu Pro Lys Gly Pro Lys Pro Thr Ala Pro Ser Ala Val
              65                  70                  75

 ggc cca aac agc aac ggc agc caa cac cca gca act gtg acc ttc agt      528
 Gly Pro Asn Ser Asn Gly Ser Gln His Pro Ala Thr Val Thr Phe Ser
          80                  85                  90

 cct gtt gac gtc cac gtg gag aca cga tga c ctctaccctg gtgctatctc      579
 Pro Val Asp Val His Val Glu Thr Arg 
      95                 100

 caccactgtc caaagagcct ctccagagtc aagacccaga ggcacactct ctggcagctt    639

 cacaacgagc ttcttctggt caggtcgaca gagac                               674




      <210> 99
      <211> 2586
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1763)

      <400> 99
 tctgcggtcg ttccctcggc tgtggaccgg gcggcacgca cgcggtgcag ggtaac         56                                                                 
 atg gcg gat gcg gaa gta att att ttg cca aag aaa cat aag aag aaa      104
 Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys
   1               5                  10                  15

 aag gag cgg aag tca ttg cca gaa gaa gat gta gcc gaa ata caa cac      152
 Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Glu Ile Gln His
              20                  25                  30

 gct gaa gaa ttt ctt atc aaa cct gaa tcc aaa gtt gct aag ttg gtc      200
 Ala Glu Glu Phe Leu Ile Lys Pro Glu Ser Lys Val Ala Lys Leu Val
          35                  40                  45

 acg tct cag tgg ccc ctt ttg cta aag aat ttt gat aag ctg aat gta      248
 Thr Ser Gln Trp Pro Leu Leu Leu Lys Asn Phe Asp Lys Leu Asn Val
      50                  55                  60

 agg aca aca cac tat aca cct ctt gca tgt ggt tca aat cct ctg aag      296
 Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn Pro Leu Lys
  65                  70                  75                  80

 aga gag att ggg gac tat atc agg aca ggt ttc att aat ctt gac aag      344
 Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn Leu Asp Lys
                  85                  90                  95

 ccc tct aac ccc tct tcc cat gag gtg gta gcc tgg att cga cgg ata      392
 Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile Arg Arg Ile
             100                 105                 110

 ctt cgg gtg gag aag aca ggg cac agt ggt act ctg gat ccc aag gtg      440
 Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp Pro Lys Val
         115                 120                 125

 act ggt tgt tta atc gtg tgc ata gaa cga gcc act cgc ttg gtg aag      488
 Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg Leu Val Lys
     130                 135                 140

 tca caa cag agt gca ggc aaa gag tat gtg ggg att gtc cgg ctg cac      536
 Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val Arg Leu His
 145                 150                 155                 160

 aat gct att gaa ggg ggg acc cag ctt tct agg gcc cta gaa act ctg      584
 Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu Glu Thr Leu
                 165                 170                 175

 aca ggt gcc tta ttc cag cga ccc cca ctt att gct gca gta aag agg      632
 Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala Val Lys Arg
             180                 185                 190

 cag ctc cga gtg agg acc atc tac gag agc aaa atg att gaa tac gat      680
 Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile Glu Tyr Asp
         195                 200                 205

 cct gaa aga aga tta gga atc ttt tgg gtg agt tgt gag gct ggc acc      728
 Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu Ala Gly Thr
     210                 215                 220

 tac att cgg aca tta tgt gtg cac ctt ggt ttg tta ttg gga gtt ggt      776
 Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu Gly Val Gly
 225                 230                 235                 240

 ggt cag atg cag gag ctt cgg agg gtt cgt tct gga gtc atg agt gaa      824
 Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val Met Ser Glu
                 245                 250                 255

 aag gac cac atg gtg aca atg cat gat gtg ctt gat gct cag tgg ctg      872
 Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala Gln Trp Leu
             260                 265                 270

 tat gat aac cac aag gat gag agt tac ctg cgg cga gtt gtt tac cct      920
 Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val Val Tyr Pro
         275                 280                 285

 ttg gaa aag ctg ttg aca tct cat aaa cgg ctg gtt atg aaa gac agt      968
 Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met Lys Asp Ser
     290                 295                 300

 gca gta agt tcc ggg tta gga gtt tat att tgg aaa gaa cgt act cca     1016
 Ala Val Ser Ser Gly Leu Gly Val Tyr Ile Trp Lys Glu Arg Thr Pro
 305                 310                 315                 320

 aag atg agg ctt gct ctt ttt att gct ttc ctt ggg ttt tgt gga ggg     1064
 Lys Met Arg Leu Ala Leu Phe Ile Ala Phe Leu Gly Phe Cys Gly Gly
                 325                 330                 335

 cag cag ctg ggc ccc tta cac ttg gtg cca tct ctg cag gta aat gcc     1112
 Gln Gln Leu Gly Pro Leu His Leu Val Pro Ser Leu Gln Val Asn Ala
             340                 345                 350

 atc tgc tat ggg gcc aag att atg ctt cca ggt gtt ctt cga tat gag     1160
 Ile Cys Tyr Gly Ala Lys Ile Met Leu Pro Gly Val Leu Arg Tyr Glu
         355                 360                 365

 gac ggc att gag gtc aat cag gag att gtg gtt atc acc acc aaa gga     1208
 Asp Gly Ile Glu Val Asn Gln Glu Ile Val Val Ile Thr Thr Lys Gly
     370                 375                 380

 gaa gca atc tgc atg gct att gca tta atg acc aca gcg gtc atc tct     1256
 Glu Ala Ile Cys Met Ala Ile Ala Leu Met Thr Thr Ala Val Ile Ser
 385                 390                 395                 400

 acc tgc gac cat ggt ata gta gcc aag atc aag aga gtg atc atg gag     1304
 Thr Cys Asp His Gly Ile Val Ala Lys Ile Lys Arg Val Ile Met Glu
                 405                 410                 415

 aga gac act tac cct cgg aag tgg ggt tta ggt cca aag gca agt cag     1352
 Arg Asp Thr Tyr Pro Arg Lys Trp Gly Leu Gly Pro Lys Ala Ser Gln
             420                 425                 430

 aag aag ctg atg atc aag cag ggc ctt ctg gac aag cat ggg aag ccc     1400
 Lys Lys Leu Met Ile Lys Gln Gly Leu Leu Asp Lys His Gly Lys Pro
         435                 440                 445

 aca gac agc aca cct gcc acc tgg aag cag gag tat gtt gac tac agt     1448
 Thr Asp Ser Thr Pro Ala Thr Trp Lys Gln Glu Tyr Val Asp Tyr Ser
     450                 455                 460

 gag tct gcc aaa aaa gag gtg gtt gct gaa gtg gta aaa gcc ccg cag     1496
 Glu Ser Ala Lys Lys Glu Val Val Ala Glu Val Val Lys Ala Pro Gln
 465                 470                 475                 480

 gta gtt gcc gaa gca gca aaa act gcg aag gtg agt ggc atg ctg tcc     1544
 Val Val Ala Glu Ala Ala Lys Thr Ala Lys Val Ser Gly Met Leu Ser
                 485                 490                 495

 tca gtt tgg aag cgg aag cga gag agt gag agt gaa agt gac gag act     1592
 Ser Val Trp Lys Arg Lys Arg Glu Ser Glu Ser Glu Ser Asp Glu Thr
             500                 505                 510

 cct cca gca gct cct cag ttg atc aag aag gaa aag aag aag agt aag     1640
 Pro Pro Ala Ala Pro Gln Leu Ile Lys Lys Glu Lys Lys Lys Ser Lys
         515                 520                 525

 aag gac aag aag gcc aaa gct ggt ctg gag agc ggg gcc gag cct gga     1688
 Lys Asp Lys Lys Ala Lys Ala Gly Leu Glu Ser Gly Ala Glu Pro Gly
     530                 535                 540

 gat ggg gac agt gat acc acc aag aag aag aag aag aag aag aaa gca     1736
 Asp Gly Asp Ser Asp Thr Thr Lys Lys Lys Lys Lys Lys Lys Lys Ala
 545                 550                 555                 560

 aaa gag gta gaa ttg gtt tct gag tag tgaag gccacttgaa gctggaggag     1788
 Lys Glu Val Glu Leu Val Ser Glu 
                 565

 aaactaaagc cttattgaga aaacatgtta tagatccttt tgttgctgag agagtggaac   1848

 ataggtccta gacagggtga agagttctgg cacattttag ctgctacttt gagacctcgg   1908

 tgatgttacc tggtgtggtc atcccatctt gtcctgtttt aaggatatgg gtggtgaaag   1968

 atgaaagagg cagagtttat cccaatgact tctctgtttg agttgggaag cctcaccttc   2028

 agacccagta actgtccgca gctgtctgct agtggttgtc ttaacatcgt agtcctagtt   2088

 tgcatttttt aaatcccctc tgtttaaaag gtttgtaaaa caaaaacaaa aaactaagtc   2148

 tgctcagtga aatgctgtag aaccctaaat aagtggtaga agagtgtcac tgaattttgt   2208

 ctctgaattc agtataactg agttttgtcc atgctggtgt ctgggttata ggcctgatgg   2268

 gcctggtagt tttccatctt gttctggcct agaggtcagt cctttgcact tcctcaaagc   2328

 ttgtgtacag tgctcaccta aatccatctg actacttgtt cctgtgccct cttgttttag   2388

 gcctcgttta cttttaaaaa atgaaattgt tcattgctgg gagaagaatg ttgtaatttt   2448

 tacttattaa agtcaacttg ttaagttttt tatgtattcc tgttgggttt tcttgttgat   2508

 ctcatgctag cagagcaaaa attgtaaaat attttgatta aaaatctagg gacctttatg   2568

 tcctatttga aaaaaaaa                                                 2586




      <210> 100
      <211> 2367
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1544)

      <400> 100
 tctgcggtcg ttccctcggc tgtggaccgg gcggcacgca cgcggtgcag ggtaac         56                                                                 
 atg gcg gat gcg gaa gta att att ttg cca aag aaa cat aag aag aaa      104
 Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys
   1               5                  10                  15

 aag gag cgg aag tca ttg cca gaa gaa gat gta gcc aat ttt gat aag      152
 Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Asn Phe Asp Lys
              20                  25                  30

 ctg aat gta agg aca aca cac tat aca cct ctt gca tgt ggt tca aat      200
 Leu Asn Val Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn
          35                  40                  45

 cct ctg aag aga gag att ggg gac tat atc agg aca ggt ttc att aat      248
 Pro Leu Lys Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn
      50                  55                  60

 ctt gac aag ccc tct aac ccc tct tcc cat gag gtg gta gcc tgg att      296
 Leu Asp Lys Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile
  65                  70                  75                  80

 cga cgg ata ctt cgg gtg gag aag aca ggg cac agt ggt act ctg gat      344
 Arg Arg Ile Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp
                  85                  90                  95

 ccc aag gtg act ggt tgt tta atc gtg tgc ata gaa cga gcc act cgc      392
 Pro Lys Val Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg
             100                 105                 110

 ttg gtg aag tca caa cag agt gca ggc aaa gag tat gtg ggg att gtc      440
 Leu Val Lys Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val
         115                 120                 125

 cgg ctg cac aat gct att gaa ggg ggg acc cag ctt tct agg gcc cta      488
 Arg Leu His Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu
     130                 135                 140

 gaa act ctg aca ggt gcc tta ttc cag cga ccc cca ctt att gct gca      536
 Glu Thr Leu Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala
 145                 150                 155                 160

 gta aag agg cag ctc cga gtg agg acc atc tac gag agc aaa atg att      584
 Val Lys Arg Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile
                 165                 170                 175

 gaa tac gat cct gaa aga aga tta gga atc ttt tgg gtg agt tgt gag      632
 Glu Tyr Asp Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu
             180                 185                 190

 gct ggc acc tac att cgg aca tta tgt gtg cac ctt ggt ttg tta ttg      680
 Ala Gly Thr Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu
         195                 200                 205

 gga gtt ggt ggt cag atg cag gag ctt cgg agg gtt cgt tct gga gtc      728
 Gly Val Gly Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val
     210                 215                 220

 atg agt gaa aag gac cac atg gtg aca atg cat gat gtg ctt gat gct      776
 Met Ser Glu Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala
 225                 230                 235                 240

 cag tgg ctg tat gat aac cac aag gat gag agt tac ctg cgg cga gtt      824
 Gln Trp Leu Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val
                 245                 250                 255

 gtt tac cct ttg gaa aag ctg ttg aca tct cat aaa cgg ctg gtt atg      872
 Val Tyr Pro Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met
             260                 265                 270

 aaa gac agt gca gta aat gcc atc tgc tat ggg gcc aag att atg ctt      920
 Lys Asp Ser Ala Val Asn Ala Ile Cys Tyr Gly Ala Lys Ile Met Leu
         275                 280                 285

 cca ggt gtt ctt cga tat gag gac ggc att gag gtc aat cag gag att      968
 Pro Gly Val Leu Arg Tyr Glu Asp Gly Ile Glu Val Asn Gln Glu Ile
     290                 295                 300

 gtg gtt atc acc acc aaa gga gaa gca atc tgc atg gct att gca tta     1016
 Val Val Ile Thr Thr Lys Gly Glu Ala Ile Cys Met Ala Ile Ala Leu
 305                 310                 315                 320

 atg acc aca gcg gtc atc tct acc tgc gac cat ggt ata gta gcc aag     1064
 Met Thr Thr Ala Val Ile Ser Thr Cys Asp His Gly Ile Val Ala Lys
                 325                 330                 335

 atc aag aga gtg atc atg gag aga gac act tac cct cgg aag tgg ggt     1112
 Ile Lys Arg Val Ile Met Glu Arg Asp Thr Tyr Pro Arg Lys Trp Gly
             340                 345                 350

 tta ggt cca aag gca agt cag aag aag ctg atg atc aag cag ggc ctt     1160
 Leu Gly Pro Lys Ala Ser Gln Lys Lys Leu Met Ile Lys Gln Gly Leu
         355                 360                 365

 ctg gac aag cat ggg aag ccc aca gac agc aca cct gcc acc tgg aag     1208
 Leu Asp Lys His Gly Lys Pro Thr Asp Ser Thr Pro Ala Thr Trp Lys
     370                 375                 380

 cag gag tat gtt gac tac agt gag tct gcc aaa aaa gag gtg gtt gct     1256
 Gln Glu Tyr Val Asp Tyr Ser Glu Ser Ala Lys Lys Glu Val Val Ala
 385                 390                 395                 400

 gaa gtg gta aaa gcc ccg cag gta gtt gcc gaa gca gca aaa act gcg     1304
 Glu Val Val Lys Ala Pro Gln Val Val Ala Glu Ala Ala Lys Thr Ala
                 405                 410                 415

 aag gtg agt ggc atg ctg tcc tca gtt tgg aag cgg aag cga gag agt     1352
 Lys Val Ser Gly Met Leu Ser Ser Val Trp Lys Arg Lys Arg Glu Ser
             420                 425                 430

 gag agt gaa agt gac gag act cct cca gca gct cct cag ttg atc aag     1400
 Glu Ser Glu Ser Asp Glu Thr Pro Pro Ala Ala Pro Gln Leu Ile Lys
         435                 440                 445

 aag gaa aag aag aag agt aag aag gac aag aag gcc aaa gct ggt ctg     1448
 Lys Glu Lys Lys Lys Ser Lys Lys Asp Lys Lys Ala Lys Ala Gly Leu
     450                 455                 460

 gag agc ggg gcc gag cct gga gat ggg gac agt gat acc acc aag aag     1496
 Glu Ser Gly Ala Glu Pro Gly Asp Gly Asp Ser Asp Thr Thr Lys Lys
 465                 470                 475                 480

 aag aag aag aag aag aaa gca aaa gag gta gaa ttg gtt tct gag tag     1544
 Lys Lys Lys Lys Lys Lys Ala Lys Glu Val Glu Leu Val Ser Glu 
                 485                 490                 495

 tgaaggccac ttgaagctgg aggagaaact aaagccttat tgagaaaaca tgttatagat   1604

 ccttttgttg ctgagagagt ggaacatagg tcctagacag ggtgaagagt tctggcacat   1664

 tttagctgct actttgagac ctcggtgatg ttacctggtg tggtcatccc atcttgtcct   1724

 gttttaagga tatgggtggt gaaagatgaa agaggcagag tttatcccaa tgacttctct   1784

 gtttgagttg ggaagcctca ccttcagacc cagtaactgt ccgcagctgt ctgctagtgg   1844

 ttgtcttaac atcgtagtcc tagtttgcat tttttaaatc ccctctgttt aaaaggtttg   1904

 taaaacaaaa acaaaaaact aagtctgctc agtgaaatgc tgtagaaccc taaataagtg   1964

 gtagaagagt gtcactgaat tttgtctctg aattcagtat aactgagttt tgtccatgct   2024

 ggtgtctggg ttataggcct gatgggcctg gtagttttcc atcttgttct ggcctagagg   2084

 tcagtccttt gcacttcctc aaagcttgtg tacagtgctc acctaaatcc atctgactac   2144

 ttgttcctgt gccctcttgt tttaggcctc gtttactttt aaaaaatgaa attgttcatt   2204

 gctgggagaa gaatgttgta atttttactt attaaagtca acttgttaag ttttttatgt   2264

 attcctgttg ggttttcttg ttgatctcat gctagcagag caaaaattgt aaaatatttt   2324

 gattaaaaat ctagggacct ttatgtccta tttgaaaaaa aaa                     2367




      <210> 101
      <211> 1403
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (502)..(1353)

      <400> 101
 ccggcgaagc ccacccggtt ttcccagcgg catttccgat gacagcttcg gggctacgtg     60

 tcctgtgctg tcggagacgc acaggaagca aagtttgtga gaagccttgg gggcgacttt    120

 gccttgggca cccgcatttg tgcgtctgcg aggtgcctcg gtgtgcgcgg agctagtttc    180

 ccagtttccc gggcccctcc cttctccgag cccctctagc gatttgttta ggaaaagtga    240

 tgacatgaac tagtagtgga gaatcgcagc gccgctcccc gccctgggga gggaggggag    300

 ccccggagag cctgccggtg ggagctggaa gcaggctccc ggctgagcgc cccagcccga    360

 aaggcagggt ctgggtgcgg gaagagggct cggagctgcc ttcctgctgc cttggggccg    420

 cccagatgag ggaacagccc gatttgcctg gttctgattc tccaggctgt cgtggttgtg    480

 gaatgcaaac gccagcacat a  atg gaa aca gga cct gaa gac cct tcc agc     531
                          Met Glu Thr Gly Pro Glu Asp Pro Ser Ser
                            1               5                  10

 atg cca gag gaa agt tcc ccc agg cgg acc ccg cag agc att ccc tac      579
 Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr
                  15                  20                  25

 cag gac ctc cct cac ctg gtc aat gca gac gga cag tac ctc ttc tgc      627
 Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys
              30                  35                  40

 agg tac tgg aaa ccc aca ggc aca ccc aag gcc ctc atc ttt gtg tcc      675
 Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser
          45                  50                  55

 cat gga gcc gga gag cac agt ggc cgc tat gaa gag ctg gct cgg atg      723
 His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met
      60                  65                  70

 ctg atg ggg ctg gac ctg ctg gtg ttc gcc cac gac cat gtt ggc cac      771
 Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His
  75                  80                  85                  90

 gga cag agc gaa ggg gag agg atg gta gtg tct gac ttc cac gtt ttc      819
 Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe
                  95                 100                 105

 gtc agg gat gtg ttg cag cat gtg gat tcc atg cag aaa gac tac cct      867
 Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro
             110                 115                 120

 ggg ctt cct gtc ttc ctt ctg ggc cac tcc atg gga ggc gcc atc gcc      915
 Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala
         125                 130                 135

 atc ctc acg gcc gca gag agg ccg ggc cac ttc gcc ggc atg gta ctc      963
 Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu
     140                 145                 150

 att tcg cct ctg gtt ctt gcc aat cct gaa tct gca aca act ttc aag     1011
 Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys
 155                 160                 165                 170

 gtc gac att tat aac tca gac ccc ctg atc tgc cgg gca ggg ctg aag     1059
 Val Asp Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys
                 175                 180                 185

 gtg tgc ttc ggc atc caa ctg ctg aat gcc gtc tca cgg gtg gag cgc     1107
 Val Cys Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val Glu Arg
             190                 195                 200

 gcc ctc ccc aag ctg act gtg ccc ttc ctg ctg ctc cag ggc tct gcc     1155
 Ala Leu Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly Ser Ala
         205                 210                 215

 gat cgc cta tgt gac agc aaa ggg gcc tac ctg ctc atg gag tta gcc     1203
 Asp Arg Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala
     220                 225                 230

 aag agc cag gac aag act ctc aag att tat gaa ggt gcc tac cat gtt     1251
 Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr His Val
 235                 240                 245                 250

 ctc cac aag gag ctt cct gaa gtc acc aac tcc gtc ttc cat gaa ata     1299
 Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His Glu Ile
                 255                 260                 265

 aac atg tgg gtc tct caa agg aca gcc acg gca gga act gcg tcc cca     1347
 Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro
             270                 275                 280

 ccc tga atgcattggc cggtgcccgg ctcatggtct gggggatgca ggcaggggaa      1403
 Pro 






      <210> 102
      <211> 1613
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (502)..(1521)

      <400> 102
 ccggcgaagc ccacccggtt ttcccagcgg catttccgat gacagcttcg gggctacgtg     60

 tcctgtgctg tcggagacgc acaggaagca aagtttgtga gaagccttgg gggcgacttt    120

 gccttgggca cccgcatttg tgcgtctgcg aggtgcctcg gtgtgcgcgg agctagtttc    180

 ccagtttccc gggcccctcc cttctccgag cccctctagc gatttgttta ggaaaagtga    240

 tgacatgaac tagtagtgga gaatcgcagc gccgctcccc gccctgggga gggaggggag    300

 ccccggagag cctgccggtg ggagctggaa gcaggctccc ggctgagcgc cccagcccga    360

 aaggcagggt ctgggtgcgg gaagagggct cggagctgcc ttcctgctgc cttggggccg    420

 cccagatgag ggaacagccc gatttgcctg gttctgattc tccaggctgt cgtggttgtg    480

 gaatgcaaac gccagcacat a  atg gaa aca gga cct gaa gac cct tcc agc     531
                          Met Glu Thr Gly Pro Glu Asp Pro Ser Ser
                            1               5                  10

 atg cca gag gaa agt tcc ccc agg cgg acc ccg cag agc att ccc tac      579
 Met Pro Glu Glu Ser Ser Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr
                  15                  20                  25

 cag gac ctc cct cac ctg gtc aat gca gac gga cag tac ctc ttc tgc      627
 Gln Asp Leu Pro His Leu Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys
              30                  35                  40

 agg tac tgg aaa ccc aca ggc aca ccc aag gcc ctc atc ttt gtg tcc      675
 Arg Tyr Trp Lys Pro Thr Gly Thr Pro Lys Ala Leu Ile Phe Val Ser
          45                  50                  55

 cat gga gcc gga gag cac agt ggc cgc tat gaa gag ctg gct cgg atg      723
 His Gly Ala Gly Glu His Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met
      60                  65                  70

 ctg atg ggg ctg gac ctg ctg gtg ttc gcc cac gac cat gtt ggc cac      771
 Leu Met Gly Leu Asp Leu Leu Val Phe Ala His Asp His Val Gly His
  75                  80                  85                  90

 gga cag agc gaa ggg gag agg atg gta gtg tct gac ttc cac gtt ttc      819
 Gly Gln Ser Glu Gly Glu Arg Met Val Val Ser Asp Phe His Val Phe
                  95                 100                 105

 gtc agg gat gtg ttg cag cat gtg gat tcc atg cag aaa gac tac cct      867
 Val Arg Asp Val Leu Gln His Val Asp Ser Met Gln Lys Asp Tyr Pro
             110                 115                 120

 ggg ctt cct gtc ttc ctt ctg ggc cac tcc atg gga ggc gcc atc gcc      915
 Gly Leu Pro Val Phe Leu Leu Gly His Ser Met Gly Gly Ala Ile Ala
         125                 130                 135

 atc ctc acg gcc gca gag agg ccg ggc cac ttc gcc ggc atg gta ctc      963
 Ile Leu Thr Ala Ala Glu Arg Pro Gly His Phe Ala Gly Met Val Leu
     140                 145                 150

 att tcg cct ctg gtt ctt gcc aat cct gaa tct gca aca act ttc aag     1011
 Ile Ser Pro Leu Val Leu Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys
 155                 160                 165                 170

 gac tat tcg agg att ttg aaa cac ttg atg gaa aag gca tca aga atg     1059
 Asp Tyr Ser Arg Ile Leu Lys His Leu Met Glu Lys Ala Ser Arg Met
                 175                 180                 185

 tta aag ttt tgg att cca cgt cct ttt tgg gtc ctt gct gcg aaa gtg     1107
 Leu Lys Phe Trp Ile Pro Arg Pro Phe Trp Val Leu Ala Ala Lys Val
             190                 195                 200

 ctc aac ctt gtg ctg cca aac ttg tcc ctc ggg ccc atc gac tcc agc     1155
 Leu Asn Leu Val Leu Pro Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser
         205                 210                 215

 gtg ctc tct cgg aat aag aca gag gtc gac att tat aac tca gac ccc     1203
 Val Leu Ser Arg Asn Lys Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro
     220                 225                 230

 ctg atc tgc cgg gca ggg ctg aag gtg tgc ttc ggc atc caa ctg ctg     1251
 Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln Leu Leu
 235                 240                 245                 250

 aat gcc gtc tca cgg gtg gag cgc gcc ctc ccc aag ctg act gtg ccc     1299
 Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr Val Pro
                 255                 260                 265

 ttc ctg ctg ctc cag ggc tct gcc gat cgc cta tgt gac agc aaa ggg     1347
 Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly
             270                 275                 280

 gcc tac ctg ctc atg gag tta gcc aag agc cag gac aag act ctc aag     1395
 Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys
         285                 290                 295

 att tat gaa ggt gcc tac cat gtt ctc cac aag gag ctt cct gaa gtc     1443
 Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro Glu Val
     300                 305                 310

 acc aac tcc gtc ttc cat gaa ata aac atg tgg gtc tct caa agg aca     1491
 Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln Arg Thr
 315                 320                 325                 330

 gcc acg gca gga act gcg tcc cca ccc tga a tgcattggcc ggtgcccggc     1542
 Ala Thr Ala Gly Thr Ala Ser Pro Pro 
                 335

 tcatggtctg ggggatgcag gcaggggaag ggcagagatg gcttctcaga tatggcttgc   1602

 aaaaaaaaaa a                                                        1613




      <210> 103
      <211> 746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (139)..(735)

      <400> 103
 cgtaccaaaa gcttcagtta cccattgctc tcgtccacag gtgatcagtt tgaaattcag     60

 ctaacccagc agctacagtc ccttatcccc aacaacaatg tgagaaggct cattgctcat    120

 gttatccgga ccttgaag  atg gac tgc tct ggg gcc cat gtg caa gtg acc     171
                      Met Asp Cys Ser Gly Ala His Val Gln Val Thr
                        1               5                  10

 tgt gcc aag ctc atc tcc agg aca ggc cac ctg atg aag ctt ctc agt      219
 Cys Ala Lys Leu Ile Ser Arg Thr Gly His Leu Met Lys Leu Leu Ser
              15                  20                  25

 ggg cag cag gaa gta aag gca tcc aag ata gaa tgg gat acg gac caa      267
 Gly Gln Gln Glu Val Lys Ala Ser Lys Ile Glu Trp Asp Thr Asp Gln
          30                  35                  40

 tgg aag att gag aac tac att aat gag agc aca gaa gcc cag agt gaa      315
 Trp Lys Ile Glu Asn Tyr Ile Asn Glu Ser Thr Glu Ala Gln Ser Glu
      45                  50                  55

 cag aaa gag aag tcg ctt gag ctc aaa aaa gaa gtt cca gga tat ggc      363
 Gln Lys Glu Lys Ser Leu Glu Leu Lys Lys Glu Val Pro Gly Tyr Gly
  60                  65                  70                  75

 tat act gac aaa ctc atc ttg gca tta att gtt act gga ata cta acg      411
 Tyr Thr Asp Lys Leu Ile Leu Ala Leu Ile Val Thr Gly Ile Leu Thr
                  80                  85                  90

 att ttg att ata ctt ttc tgc ctt att gtg ata tgt tgt cac cga agg      459
 Ile Leu Ile Ile Leu Phe Cys Leu Ile Val Ile Cys Cys His Arg Arg
              95                 100                 105

 tca tta caa gaa gat gaa gaa gga ttc tca agg ggc att ttc aga ttt      507
 Ser Leu Gln Glu Asp Glu Glu Gly Phe Ser Arg Gly Ile Phe Arg Phe
         110                 115                 120

 ctg cca cgg agg gga tgc tct tcg cga agg gag agt cag gat gga ctt      555
 Leu Pro Arg Arg Gly Cys Ser Ser Arg Arg Glu Ser Gln Asp Gly Leu
     125                 130                 135

 tcc tca ttt gga cag ccg ctc tgg ttt aaa gat atg tac aaa cct ctc      603
 Ser Ser Phe Gly Gln Pro Leu Trp Phe Lys Asp Met Tyr Lys Pro Leu
 140                 145                 150                 155

 agt gcc aca aga ata aat aat cat gca tgg aag ctg cac aag aag tca      651
 Ser Ala Thr Arg Ile Asn Asn His Ala Trp Lys Leu His Lys Lys Ser
                 160                 165                 170

 tct aat gag gac aag atc ctc aac agg gac cct ggg gac agc gaa gcc      699
 Ser Asn Glu Asp Lys Ile Leu Asn Arg Asp Pro Gly Asp Ser Glu Ala
             175                 180                 185

 cca acg gag gag gag gag agt gaa gcc ctg cca tag gaggagaaca c         746
 Pro Thr Glu Glu Glu Glu Ser Glu Ala Leu Pro 
         190                 195





      <210> 104
      <211> 1057
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (129)..(791)

      <400> 104
 aaatcgactc gctcggtgtt cgcccgccga cgccgcacgg cttgctgggg ctgggctctt     60

 cctcgcggaa gtggggagga ggcggttgcg gttagtggac cgggaccggt aggggtgctg    120

 ttgccatc atg gct gac ccc gac ccc cgg tac cct cgc tcc tcg atc gag     170
          Met Ala Asp Pro Asp Pro Arg Tyr Pro Arg Ser Ser Ile Glu
            1               5                  10

 gac gac ttc aac tat ggc agc agc gtg gcc tcc gcc acc gtg cac atc      218
 Asp Asp Phe Asn Tyr Gly Ser Ser Val Ala Ser Ala Thr Val His Ile
  15                  20                  25                  30

 cga atg gcc ttt ctg aga gtt ttt tta tac ttt gag tct gta cgg aca      266
 Arg Met Ala Phe Leu Arg Val Phe Leu Tyr Phe Glu Ser Val Arg Thr
                  35                  40                  45

 ttt gta cat gag agt cct gcc tta att ttg ctg ttt gcc ctc gga tct      314
 Phe Val His Glu Ser Pro Ala Leu Ile Leu Leu Phe Ala Leu Gly Ser
              50                  55                  60

 ctg ggt ttg att ttt gcg ttg act tta aac aga cat aag tat ccc ctt      362
 Leu Gly Leu Ile Phe Ala Leu Thr Leu Asn Arg His Lys Tyr Pro Leu
          65                  70                  75

 aac ctg tac cta ctt ttt gga ttt acg ctg ttg gaa gct ctg act gtg      410
 Asn Leu Tyr Leu Leu Phe Gly Phe Thr Leu Leu Glu Ala Leu Thr Val
      80                  85                  90

 gca gtt gtt gtt act ttc tat gat gta tat att att ctg caa gct ttc      458
 Ala Val Val Val Thr Phe Tyr Asp Val Tyr Ile Ile Leu Gln Ala Phe
  95                 100                 105                 110

 ata ctg act act aca gta ttt ttt ggt ttg act gtg tat act cta caa      506
 Ile Leu Thr Thr Thr Val Phe Phe Gly Leu Thr Val Tyr Thr Leu Gln
                 115                 120                 125

 tct aag aag gat ttc agc aaa ttt gga gca ggg ctg ttt gct ctt ttg      554
 Ser Lys Lys Asp Phe Ser Lys Phe Gly Ala Gly Leu Phe Ala Leu Leu
             130                 135                 140

 tgg ata ttg tgc ctg tca gga ttc ttg aag ttt ttt ttt tat agt gag      602
 Trp Ile Leu Cys Leu Ser Gly Phe Leu Lys Phe Phe Phe Tyr Ser Glu
         145                 150                 155

 ata atg gag ttg gtc tta gcc gct gca gga gcc ctt ctt ttc tgt gga      650
 Ile Met Glu Leu Val Leu Ala Ala Ala Gly Ala Leu Leu Phe Cys Gly
     160                 165                 170

 ttc atc atc tat gac aca cac tca ctg atg cat aaa ctg tca cct gaa      698
 Phe Ile Ile Tyr Asp Thr His Ser Leu Met His Lys Leu Ser Pro Glu
 175                 180                 185                 190

 gag tac gta tta gct gcc atc agc ctc tac ttg gat atc atc aat cta      746
 Glu Tyr Val Leu Ala Ala Ile Ser Leu Tyr Leu Asp Ile Ile Asn Leu
                 195                 200                 205

 ttc ctg cac ctg tta cgg ttt ctg gaa gca gtt aat aaa aag taa tta      794
 Phe Leu His Leu Leu Arg Phe Leu Glu Ala Val Asn Lys Lys 
             210                 215                 220

 aaagtatctc agctcaactg aagaacaaca aaaaaaattt aacgagaaaa aaggattaaa    854

 gtaattggaa gcagtatata gaaactgttt cattaagtaa taaagtttga aacaatgatt    914

 aaatactgtt acaatcttta tttgtatcat atgtaatttt gagagcttta aaatcttact    974

 attctttatg atacctcatt tctaaatcct tgatttagga tctcagttaa gagctatcaa   1034

 aattctatta aaaatgcttt tct                                           1057




      <210> 105
      <211> 2458
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (302)..(859)

      <400> 105
 attacaactg ggtccgtaca accgccggca agtccagccc tttccgaaaa gggtgaagat     60

 ctcccccccc atgtctgtca ctgcctctgc catcggctga tccttttcca gccatagaac    120

 tcccacaggc atcccatctg acaccaccct gccacgtgga tggagatgca ctcacgcatg    180

 actagaactt gaagggtctt cgcggtgaag gagcgaagga cgcacaccag gatctccggt    240

 ttcggttgga ggactcgttg gggaggtggc ctgcgcttgt agagactgca tccccgagac    300

 g    atg gcg gag gga gat aat cgc agc acc aac ctg ctg gct gca gag     346
      Met Ala Glu Gly Asp Asn Arg Ser Thr Asn Leu Leu Ala Ala Glu
        1               5                  10                  15

 act gca agt ctg gaa gaa cag ctg caa gga tgg gga gaa gtg atg ctg      394
 Thr Ala Ser Leu Glu Glu Gln Leu Gln Gly Trp Gly Glu Val Met Leu
                  20                  25                  30

 atg gct gat aaa gtc ctc cga tgg gaa aga gcc tgg ttt cca cct gcc      442
 Met Ala Asp Lys Val Leu Arg Trp Glu Arg Ala Trp Phe Pro Pro Ala
              35                  40                  45

 atc atg ggt gtg gtt tct ttg gtg ttt ctg att atc tac tat cta gat      490
 Ile Met Gly Val Val Ser Leu Val Phe Leu Ile Ile Tyr Tyr Leu Asp
          50                  55                  60

 cca tct gtt ctg tcc ggc gtt tcc tgt ttt gtt atg ttt ttg tgc ttg      538
 Pro Ser Val Leu Ser Gly Val Ser Cys Phe Val Met Phe Leu Cys Leu
      65                  70                  75

 gct gac tac ctt gtt ccc att cta gcg cct aga att ttt ggc tcc aat      586
 Ala Asp Tyr Leu Val Pro Ile Leu Ala Pro Arg Ile Phe Gly Ser Asn
  80                  85                  90                  95

 aaa tgg acc act gaa caa cag caa aga ttc cat gaa att tgc agc aat      634
 Lys Trp Thr Thr Glu Gln Gln Gln Arg Phe His Glu Ile Cys Ser Asn
                 100                 105                 110

 cta gta aaa act cga cgc aga gct gtg ggt tgg tgg aaa cgc ctc ttc      682
 Leu Val Lys Thr Arg Arg Arg Ala Val Gly Trp Trp Lys Arg Leu Phe
             115                 120                 125

 aca cta aag gaa gag gtg gga caa caa gtc cac aac ctg ctt ctc acc      730
 Thr Leu Lys Glu Glu Val Gly Gln Gln Val His Asn Leu Leu Leu Thr
         130                 135                 140

 tac ctg ata gtg act tcc tta cta ttg ctt cct gga cta aac caa cat      778
 Tyr Leu Ile Val Thr Ser Leu Leu Leu Leu Pro Gly Leu Asn Gln His
     145                 150                 155

 gga atc att ttg aag tac att gga atg gcc aag agg gag ata aac aaa      826
 Gly Ile Ile Leu Lys Tyr Ile Gly Met Ala Lys Arg Glu Ile Asn Lys
 160                 165                 170                 175

 ctt ctc aaa caa aaa gaa aag aaa aac gaa tga ttcatctg ctttaatcag      877
 Leu Leu Lys Gln Lys Glu Lys Lys Asn Glu 
                 180                 185

 tgtgattaat gcagcaccca ttgccccggg aaccgtttct gctgtactat ctggatacta    937

 aaatgttacg gaagtagctc tttgttctcc ctcactctgc ccttagttaa tagaaattca    997

 gactcgccaa gtaaggcttc gtgcatagtg tcttcatgtc gcgtatagtt gagcgcgttc   1057

 ttagcagttg gcttcatgga caactcatta gtgttttgac ttttcttacc cagcgttaat   1117

 tgaattcttg cttttagaca acttcctttt tgtagtggtg aaccttgccc tttagtacag   1177

 ttcaagtgaa tctggataat tgttcatctt tgctttagct tagataccat gtagtggtct   1237

 gtggctacag gaagctggtt ctgtctgctt ccacagtctg cttaaaaaac tgtctgactt   1297

 cgtgaatata gagaccaagt ttaccacttc tgatgaagag accaattaag attcattcct   1357

 cattctgttt ctttccagtg ggagaagagt ccccatgaaa taagatgaaa ctgattccat   1417

 gcactagtac atgtaggctt ctcccttgtg caaagcttag caatttgtag gaaactttga   1477

 tctttttgtc caagaaaagg aatgtctgac aggcttaagc tttcgtcccc ttgcacttag   1537

 actcgaagtt agtaaatcct taaaggcttt ttaatagcag acttccaaaa gattgcattt   1597

 aggatttcta gcatgctttt aatttcagat tttcagctga cattagctat agtatacagt   1657

 aggttaagac tcatgtctat gactttcact ctaagactgg caaaaggaca gcagtcttct   1717

 atgtttagtc aatattcatt tcagtagaag ataatcttat ctaatttttg agaccagaat   1777

 aagcctttta aggtaaacct caaaattatc attttatggt aatactgacc attttagtcc   1837

 cctaggtttg acatgggaga tagtgactac actggtgtct gacttttttc ctagagattt   1897

 ctccctgaaa aatacaaggg ctgttggtga gagcagactt gaggtgatga tagttggcct   1957

 ctggtctaca aagatttcat aactccttgg aaagcttctt ataatcattc ttaacttctt   2017

 ggtagctaga aatttagagt agttgaaatc tttaggaatg aacttctgag ggccaaaaaa   2077

 tgtgactgac gggaacaatt cttaaactga ttaactagct gtaatatagt tttgtgaatt   2137

 tattgcactg atgttgtacc ttgtggtata tctgtcccta ttaaataagt gttgttttct   2197

 cctctttaat attgctgtga acagtggtgc ccattgtagc atatgtttga ttttttttta   2257

 ttatttcata agaaaactac gttaatttta ccttactttc attgtaaata agcctgtctt   2317

 cctatctgga tttttttgtg tgcatacata ttctactgat taactacttt tgcagtttta   2377

 atcctgtatt atttcttcta ctttgttttg tgtaaaaggg gaaaaaataa aaaaagctgg   2437

 aatcttaaaa aaaaaaaaaa a                                             2458




      <210> 106
      <211> 4704
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (578)..(2878)

      <220>
      <221> misc_feature
      <222> (1)...(4704)
      <223> n = a,t,c or g

      <400> 106
 gttttctgtg ttggctgtct tgtaagtttg ctgcttcctt cttcttgcgt atcttgggtc     60

 ggttcgtgcg ctgcttcgag atagtgtgct tttctcttgc ggggttttgc tctgtctgct    120

 ctttgttgcg tctcttttct gtcttgtatt ggttcgtgct gtcttctttg ggttgttctc    180

 gttgtggttc tctcttccac gtgtctcatc tcggttgtcc cgcttgaact tgcgcacggg    240

 tagaccaccc cgggttattt caggcgagtt cgcgtgttcc cccgatgctc tgttgtgctg    300

 cgcggcgctc ggttgtcaga tctagtccac attccgtgcg cccaaggcag caccagtcac    360

 ttccgtatca ggggccgtct ctccgtaggc caaagtctcg gtcaccttcc tccccagtgt    420

 ccagctccct caagggccac aagcagcgtg taggccacct gctgcggcat gtagaagaaa    480

 gggtgccgtg gcgaacgctg ggcacgtccg cgtgctggat ccgcgaaccg tactcgtcca    540

 tgatatacca caccggcatc ttctcctcag ctgtccc atg ggc cag ctg gta ggt     595
                                          Met Gly Gln Leu Val Gly
                                            1               5

 ctg gtt gaa ctt cca cat ctc ctc cag cac cag ggc cac agc ctc tgt      643
 Leu Val Glu Leu Pro His Leu Leu Gln His Gln Gly His Ser Leu Cys
              10                  15                  20

 act ggg cag ctc acc gtg gaa ctc aat gcc cat cag gtt ggc cat gcg      691
 Thr Gly Gln Leu Thr Val Glu Leu Asn Ala His Gln Val Gly His Ala
          25                  30                  35

 gtg cag cag ccc ggg cac ctg ctg cag ctg ctg gcg cgc gtg ctc cac      739
 Val Gln Gln Pro Gly His Leu Leu Gln Leu Leu Ala Arg Val Leu His
      40                  45                  50

 acg gca cgt cca ggc gtg gtc gat gag gaa gat gct gtt ggg gtg ggc      787
 Thr Ala Arg Pro Gly Val Val Asp Glu Glu Asp Ala Val Gly Val Gly
  55                  60                  65                  70

 tgc ctg gag ccc gct ctc cct ggt cac gat gac ctt gta gca cag ctc      835
 Cys Leu Glu Pro Ala Leu Pro Gly His Asp Asp Leu Val Ala Gln Leu
                  75                  80                  85

 gtt ccc cgg gtt ggg ctg ctg ctt ccg cac ctc ccg ggc tgc ctc gtc      883
 Val Pro Arg Val Gly Leu Leu Leu Pro His Leu Pro Gly Cys Leu Val
              90                  95                 100

 ctc ctc ctc ttc tac ctc ctc cac ttg cat gat ccc aaa cac ttc ccc      931
 Leu Leu Leu Phe Tyr Leu Leu His Leu His Asp Pro Lys His Phe Pro
         105                 110                 115

 agc gtc gaa aac atg gag gcc gag cgg ggt ccc gag cgc cgg cct gcg      979
 Ser Val Glu Asn Met Glu Ala Glu Arg Gly Pro Glu Arg Arg Pro Ala
     120                 125                 130

 gag cgt agc agc ccg ggc cag acg ccg gag gag ggc gcg cag gcc ttg     1027
 Glu Arg Ser Ser Pro Gly Gln Thr Pro Glu Glu Gly Ala Gln Ala Leu
 135                 140                 145                 150

 gcc gag ttc gcg gcg ctg cac ggc ccg gcg ctg cgc gct tcg ggg gtc     1075
 Ala Glu Phe Ala Ala Leu His Gly Pro Ala Leu Arg Ala Ser Gly Val
                 155                 160                 165

 ccc gaa cgt tac tgg ggc cgc ctc ctg cac aag ctg gag cac gag gtt     1123
 Pro Glu Arg Tyr Trp Gly Arg Leu Leu His Lys Leu Glu His Glu Val
             170                 175                 180

 ttc gac gct ggg gaa gtg ttt ggg atc atg caa gtg gag gag gta gaa     1171
 Phe Asp Ala Gly Glu Val Phe Gly Ile Met Gln Val Glu Glu Val Glu
         185                 190                 195

 gag gag gag gac gag gca gcc cgg gag gtg cgg aag cag cag ccc aac     1219
 Glu Glu Glu Asp Glu Ala Ala Arg Glu Val Arg Lys Gln Gln Pro Asn
     200                 205                 210

 ccg ggg aac gag ctg tgc tac aag gtc atc gtg acc agg gag agc ggg     1267
 Pro Gly Asn Glu Leu Cys Tyr Lys Val Ile Val Thr Arg Glu Ser Gly
 215                 220                 225                 230

 ctc cag gca gcc cac ccc aac agc atc ttc ctc atc gac cac gcc tgg     1315
 Leu Gln Ala Ala His Pro Asn Ser Ile Phe Leu Ile Asp His Ala Trp
                 235                 240                 245

 acg tgc cgt gtg gag cac gcg cgc cag cag ctg cag cag gtg ccc ggg     1363
 Thr Cys Arg Val Glu His Ala Arg Gln Gln Leu Gln Gln Val Pro Gly
             250                 255                 260

 ctg ctg cac cgc atg gcc aac ctg atg ggc att gag ttc cac ggt gag     1411
 Leu Leu His Arg Met Ala Asn Leu Met Gly Ile Glu Phe His Gly Glu
         265                 270                 275

 ctg ccc agt aca gag gct gtg gcc ctg gtg ctg gag gag atg tgg aag     1459
 Leu Pro Ser Thr Glu Ala Val Ala Leu Val Leu Glu Glu Met Trp Lys
     280                 285                 290

 ttc aac cag acc tac cag ctg gcc cat ggg aca gct gag gag aag atg     1507
 Phe Asn Gln Thr Tyr Gln Leu Ala His Gly Thr Ala Glu Glu Lys Met
 295                 300                 305                 310

 ccg gtg tgg tat atc atg gac gag ttc ggt tcg cgg atc cag cac gcg     1555
 Pro Val Trp Tyr Ile Met Asp Glu Phe Gly Ser Arg Ile Gln His Ala
                 315                 320                 325

 gac gtg ccc agc ttc gcc acg gca ccc ttc ttc tac atg ccg cag cag     1603
 Asp Val Pro Ser Phe Ala Thr Ala Pro Phe Phe Tyr Met Pro Gln Gln
             330                 335                 340

 gtg gcc tac acg ctg ctg tgg ccc ctg agg gac ctg gac act ggc gag     1651
 Val Ala Tyr Thr Leu Leu Trp Pro Leu Arg Asp Leu Asp Thr Gly Glu
         345                 350                 355

 gag gtg acc cga gac ttt gcc tac gga gag acg gac ccc ctg atc cgg     1699
 Glu Val Thr Arg Asp Phe Ala Tyr Gly Glu Thr Asp Pro Leu Ile Arg
     360                 365                 370

 aag tgc atg ctg ctg ccc tgg gcc ccc acc gac atg ctg gac ctc agc     1747
 Lys Cys Met Leu Leu Pro Trp Ala Pro Thr Asp Met Leu Asp Leu Ser
 375                 380                 385                 390

 tct tgc aca ccc gag ccg ccc gcc gag cac tac cag gcc att ctg gag     1795
 Ser Cys Thr Pro Glu Pro Pro Ala Glu His Tyr Gln Ala Ile Leu Glu
                 395                 400                 405

 gaa aac aag gag aag ctg cca ctt gac atc aac ccc gtg gtg cac ccc     1843
 Glu Asn Lys Glu Lys Leu Pro Leu Asp Ile Asn Pro Val Val His Pro
             410                 415                 420

 cac ggc cac atc ttc aag gtc tac acg gac gtg cag cag gtg gcc agc     1891
 His Gly His Ile Phe Lys Val Tyr Thr Asp Val Gln Gln Val Ala Ser
         425                 430                 435

 agc ctc acc cac ccg cgc ttc acc ctc acc cag agt gag gcg gac gcc     1939
 Ser Leu Thr His Pro Arg Phe Thr Leu Thr Gln Ser Glu Ala Asp Ala
     440                 445                 450

 gac atc ctc ttc aac ttc tca cac ttc aag gac tac agg aaa ctc agc     1987
 Asp Ile Leu Phe Asn Phe Ser His Phe Lys Asp Tyr Arg Lys Leu Ser
 455                 460                 465                 470

 cag gag agg cca ggc gtg ctg ctg aac cag ttc ccc tgc gag aac ctg     2035
 Gln Glu Arg Pro Gly Val Leu Leu Asn Gln Phe Pro Cys Glu Asn Leu
                 475                 480                 485

 ctg act gtc aag gac tgc ctg gcc tcc atc gcg cgc cgg gca ggt ggc     2083
 Leu Thr Val Lys Asp Cys Leu Ala Ser Ile Ala Arg Arg Ala Gly Gly
             490                 495                 500

 ccc gag ggc cca ccc tgg ctg ccc cga acc ttc aac ctg cgc act gag     2131
 Pro Glu Gly Pro Pro Trp Leu Pro Arg Thr Phe Asn Leu Arg Thr Glu
         505                 510                 515

 ctg ccc cag ttt gtc agc tac ttc cag cag cgg gaa agg tgg ggc gag     2179
 Leu Pro Gln Phe Val Ser Tyr Phe Gln Gln Arg Glu Arg Trp Gly Glu
     520                 525                 530

 gac aac cac tgg atc tgc aag ccc tgg aac ctg gcg cgc agc ctg gac     2227
 Asp Asn His Trp Ile Cys Lys Pro Trp Asn Leu Ala Arg Ser Leu Asp
 535                 540                 545                 550

 acc cac gtc acc aag agc ctg cac agc atc atc cgg cac cga gag agc     2275
 Thr His Val Thr Lys Ser Leu His Ser Ile Ile Arg His Arg Glu Ser
                 555                 560                 565

 acc ccc aag gtt gtg tcc aag tac atc gaa agt ccc gtg ttg ttc ctt     2323
 Thr Pro Lys Val Val Ser Lys Tyr Ile Glu Ser Pro Val Leu Phe Leu
             570                 575                 580

 cga gaa gac gtg gga aag gtc aag ttc gac atc cgc tac atc gtg ctg     2371
 Arg Glu Asp Val Gly Lys Val Lys Phe Asp Ile Arg Tyr Ile Val Leu
         585                 590                 595

 ctg cgg tca gtg agg ccc cta cgg ttg ttc gtg tat gat gtg ttc tgg     2419
 Leu Arg Ser Val Arg Pro Leu Arg Leu Phe Val Tyr Asp Val Phe Trp
     600                 605                 610

 ctg cgg ttc tcc aac cgg gcc ttt gca ctc aac gac ctg gat gac tac     2467
 Leu Arg Phe Ser Asn Arg Ala Phe Ala Leu Asn Asp Leu Asp Asp Tyr
 615                 620                 625                 630

 gag aag cac ttc acg gtc atg aac tat gac ccg gat gtg gtg ctg aag     2515
 Glu Lys His Phe Thr Val Met Asn Tyr Asp Pro Asp Val Val Leu Lys
                 635                 640                 645

 cag gtg cac tgt gaa gag ttc atc ccc gag ttt gag aag caa tac cca     2563
 Gln Val His Cys Glu Glu Phe Ile Pro Glu Phe Glu Lys Gln Tyr Pro
             650                 655                 660

 gaa ttt ccc tgg acg gac gtc cag gct gag atc ttc cgg gcc ttc acg     2611
 Glu Phe Pro Trp Thr Asp Val Gln Ala Glu Ile Phe Arg Ala Phe Thr
         665                 670                 675

 gag ctg ttc cag gtg gcc tgt gcc aag cca cca ccc ctg ggc ctc tgc     2659
 Glu Leu Phe Gln Val Ala Cys Ala Lys Pro Pro Pro Leu Gly Leu Cys
     680                 685                 690

 gac tac ccc tca tcc cgg gcc atg tat gcc gtc gac ctc atg ctg aag     2707
 Asp Tyr Pro Ser Ser Arg Ala Met Tyr Ala Val Asp Leu Met Leu Lys
 695                 700                 705                 710

 tgg gac aac ggc cca gat gga agg cgg gtg atg cag ccg cag atc ctg     2755
 Trp Asp Asn Gly Pro Asp Gly Arg Arg Val Met Gln Pro Gln Ile Leu
                 715                 720                 725

 gag gtg aac ttc aac ccc gac tgt gag cga gcc tgc agg tac cac ccc     2803
 Glu Val Asn Phe Asn Pro Asp Cys Glu Arg Ala Cys Arg Tyr His Pro
             730                 735                 740

 acc ttc ttc aac gac gtc ttc agc acc ttg ttt ctg gac cag ccc ggt     2851
 Thr Phe Phe Asn Asp Val Phe Ser Thr Leu Phe Leu Asp Gln Pro Gly
         745                 750                 755

 ggc tgc cac gtt acc tgc ctt gtc tag gcact cgctgtcccc aaaacctgtg     2903
 Gly Cys His Val Thr Cys Leu Val 
     760                 765

 cttggggcag gattccaacc tcagttctct gagctgcttc tgcaaaggcc cccatgtccc   2963

 tccccacacc ggccctgggc atagcctcag ccccaggcct ctgtcctgcc gagccatcct   3023

 cccggcgcca cactccggga gcacagcatc ctcctctcac ctgtgggtca gagcaggaca   3083

 gtgatggtgt ccccagggct gagcaccacc ccacgccctg ccctcacccc tcaccaccat   3143

 ctgtgcactg atgagtctcc agtttagcca agggctttgt tcctggcatg gagaatttgt   3203

 tcctggctgc tgtgtttcca gggggtgctg ggggaagggt tccgtggagc gagacaaggt   3263

 gtcctcggga gcagggttcc accgggaagc gtttgggagc cctgtatcac acggggcagg   3323

 cgggtttctc ttccggggtc tctgctctta tgcatcagga cgaccccggg acggctgtgg   3383

 ggccccacac tgcacccaca gggctctatg cgacaggggc ccaggaacag cctgaggcca   3443

 ccacccagca agcccgcctt atcacccatt ccagctcacc cagaaccttc accagcaaac   3503

 ctcctgctga ggtcctggca ggaggccacc gtcttgttac cgtttccttt tcgtttgctg   3563

 agggtcacag accccaacag ggaaatcagt atctgtcttc ccagtggttg ccctgctcgc   3623

 cgggcactcc acggggtccc gcccttgtgt gagatgggcc aggatccttc ggcaaggggc   3683

 gcctggggct ggggctgatt gtgggcggtg gagcgccaga cagaaaagga ttccaatgag   3743

 aacttcaggt taaagtcaga tgccacctac cagggtctac agtcaaaatg ttggcttttt   3803

 cttatttttt aatgtatggg agaaaaatgt aaaattccag ttcttttcta attgtgtttc   3863

 tgaaattagg agtcagctgc cagcgttttt gtgtggctgc agtgtgcctg ggcccagctc   3923

 acgggcagtg ggtggaccta actgcccagg caggcgagag ctacttccag agccttccag   3983

 tgcatgggag ggcagggcta ggtgtagcgg tgtctcctct ttgaaattaa gaactatctt   4043

 tcttgtagca aagctgcaca tgatgatgct gcctctcctc tctgtgttgt ctgggccctt   4103

 gtttacaagc acgcgttacc cttcctgagg ggagccatgc tctagcccct ggagggcctg   4163

 ttgcaggggc agggcgggcc cgttgccttt ggcagctcct ggagagctgt ggacatgcag   4223

 tccccctcag ttcgtgctgc aataaaggcc atcttctctt atttctgccc tcctttctct   4283

 ttggaccctg gagccacagg ctcagcctgg cctgtcgccc cggctgtcac tgaaaagccc   4343

 cggataccaa gaagtcaccc acaaaaagtg ggagaagaaa taagatggcc tttatatcgc   4403

 aggcctccac cccacagtct gatttccatg tgctggatct gtttccaagt cggccgggag   4463

 cctcggtcct cgagtggccc cgcagctcta gtggccctgg agatagtggc ctccccacac   4523

 ttgcctcctt gtcctggggt ggggacggtg agaaaccctg gctgctgggg cgtctgcagg   4583

 gcccctcggg ccactgttga gcaggtgcat ggacaccgtc agtgggtgga agcagcgcca   4643

 catggtgacc aaggatnnta agactcagaa ggcaggccag acgaaattgt cgacccggga   4703

 a                                                                   4704




      <210> 107
      <211> 1357
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(1307)

      <400> 107
 tcccggcccg ccggccccgg agcggagcgg agcggagg    atg cag cag ccg cag      53
                                              Met Gln Gln Pro Gln
                                                1               5

 ccg cag ggg cag cag cag ccg ggg ccg ggg cag cag ctg ggg ggc cag      101
 Pro Gln Gly Gln Gln Gln Pro Gly Pro Gly Gln Gln Leu Gly Gly Gln
                  10                  15                  20

 ggg gcg gcg ccg ggg gcc ggg ggc ggc cca ggg ggg ggc ccg ggg ccg      149
 Gly Ala Ala Pro Gly Ala Gly Gly Gly Pro Gly Gly Gly Pro Gly Pro
              25                  30                  35

 ggg ccc tgc ctg agg cga gag ctg aag ctg ctc gag tcc atc ttc cac      197
 Gly Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu Glu Ser Ile Phe His
          40                  45                  50

 cgc ggc cac gag cgc ttc cgc att gcc agc gcc tgc ctg gac gag ctg      245
 Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala Cys Leu Asp Glu Leu
      55                  60                  65

 agc tgc gag ttc ctg ctg gct ggg gcc gga ggg gcc ggg gcg ggg gcc      293
 Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly Ala Gly Ala Gly Ala
  70                  75                  80                  85

 gcg ccc gga ccg cat ctc ccc cca cgg ggg tcg gtg cct ggg gat cct      341
 Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser Val Pro Gly Asp Pro
                  90                  95                 100

 gtc cgc atc cac tgc aac atc acg gag tca tac cct gct gtg ccc ccc      389
 Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr Pro Ala Val Pro Pro
             105                 110                 115

 atc tgg tcg gtg gag tct gat gac cct aac ttg gct gct gtc ttg gag      437
 Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu Ala Ala Val Leu Glu
         120                 125                 130

 agg ctg gtg gac ata aag aaa ggg aat act ctg cta ttg cag cat ctg      485
 Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu Leu Leu Gln His Leu
     135                 140                 145

 aag agg atc atc tcc gac ctg tgt aaa ctc tat aac ctc cct cag cat      533
 Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr Asn Leu Pro Gln His
 150                 155                 160                 165

 cca gat gtg gag atg ctg gat caa ccc ttg cca gca gag cag tgc aca      581
 Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro Ala Glu Gln Cys Thr
                 170                 175                 180

 cag gaa gac gtg tct tca gaa gat gaa gat gag gag atg cct gag gac      629
 Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu Glu Met Pro Glu Asp
             185                 190                 195

 aca gaa gac tta gat cac tat gaa atg aaa gag gaa gag cca gct gag      677
 Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu Glu Glu Pro Ala Glu
         200                 205                 210

 ggc aag aaa tct gaa gat gat ggc att gga aaa gaa aac ttg gcc atc      725
 Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys Glu Asn Leu Ala Ile
     215                 220                 225

 cta gag aaa att aaa aag aac cag agg caa gat tac tta aat ggt gca      773
 Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp Tyr Leu Asn Gly Ala
 230                 235                 240                 245

 gtg tct ggc tcg gtg cag gcc act gac cgg ctg atg aag gag ctc agg      821
 Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu Met Lys Glu Leu Arg
                 250                 255                 260

 gat ata tac cga tca cag agt ttc aaa ggc gga aac tat gca gtc gaa      869
 Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly Asn Tyr Ala Val Glu
             265                 270                 275

 ctc gtg aat gac agt ctg tat gat tgg aat gtc aaa ctc ctc aaa gtt      917
 Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val Lys Leu Leu Lys Val
         280                 285                 290

 gac cag gac agc gct ttg cac aac gat ctc cag atc ctc aaa gag aaa      965
 Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln Ile Leu Lys Glu Lys
     295                 300                 305

 gaa gga gcc gac ttc att cta ctt aac ttt tcc ttt aaa gat aac ttt     1013
 Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser Phe Lys Asp Asn Phe
 310                 315                 320                 325

 ccc ttt gac cca cca ttt gtc agg gtt gtg tct cca gtc ctc tct gga     1061
 Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser Pro Val Leu Ser Gly
                 330                 335                 340

 ggg tat gtt ctg ggc gga ggg gcc atc tgc atg gaa ctt ctc acc aaa     1109
 Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met Glu Leu Leu Thr Lys
             345                 350                 355

 cag ggc tgg agc agt gcc tac tcc ata gag tca gtg atc atg cag atc     1157
 Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser Val Ile Met Gln Ile
         360                 365                 370

 agt gcc aca ctg gtg aag ggg aaa gca cga gtg cag ttt gga gcc aac     1205
 Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val Gln Phe Gly Ala Asn
     375                 380                 385

 aaa tct caa tac agt ctg aca aga gca cag cag tcc tac aag tcc ttg     1253
 Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln Ser Tyr Lys Ser Leu
 390                 395                 400                 405

 gtg cag atc cac gaa aaa aac ggc tgg tac aca ccc cca aaa gaa gac     1301
 Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr Pro Pro Lys Glu Asp
                 410                 415                 420

 ggc taa ccctggagta tcacccttcc tccctcccca ggcaccactg gaccaattac      1357
 Gly 






      <210> 108
      <211> 2217
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (734)..(2170)

      <400> 108
 caactttact ggacatacct ttattgctcg cctattggca ggcgaaatgg gtaaagttta     60

 catatatatg aatgaaattg gctagtttgg aatctcctct ttggatatgt aagacaaaaa    120

 agtaacaaaa ataggtagta cttattgcac gtaagaaatg atttttatga gataatcccc    180

 tgggaccaac tacgcttaaa ctttatcctt cgcctataat ttctgaagtt actaactcaa    240

 caaaaatgag aataagccca aaatagaagc aagcatcagg ttaactgacg tcatttaaca    300

 ggtccactga agttgtttta ttaggcacaa gatttaactt ggacacttcc tccaaacacc    360

 tcagggttcc ttgcccaacc tcctcgaata cagcctctct gggagtttcc ctctccccga    420

 ctcagccgcg ctggtccctg ccttttcagc gctacctgcc ctccgtctgg gacctggctc    480

 ctttcctctc gccggtgttt cctcgccacc cgcggaggtg gagggcggac cccagcctcc    540

 ttgccgcctg ccccgcctcc ccgcctcccc gccggcccgg ctctgggccg cgcaggcgca    600

 ccaggcgcgg tccggaggcc gagggcgacc acagcagcct ccgcctcctg ctgctccgga    660

 ctattctgcg ctgggctagt cggcggtgac ccggactgcg cccggccagt ggcttcgcgg    720

 gcgacgcgtc gcc   atg ggc tct cgc tgg agc agc gaa gag gag agg cag     769
                  Met Gly Ser Arg Trp Ser Ser Glu Glu Glu Arg Gln
                    1               5                  10

 ccg ctg ctg ggg ccc ggg ctc ggg cct ggg ctg ggg gcc tcc tgg aga      817
 Pro Leu Leu Gly Pro Gly Leu Gly Pro Gly Leu Gly Ala Ser Trp Arg
          15                  20                  25

 agc cgg gag gcg gcg gcg gcg gcg ctg ccc gcg gcg gtc ccg ggt ccc      865
 Ser Arg Glu Ala Ala Ala Ala Ala Leu Pro Ala Ala Val Pro Gly Pro
      30                  35                  40

 ggg cgg gta tac ggg cgc cgc tgg ctg gtg ctg ctg ctc ttc tcg ctg      913
 Gly Arg Val Tyr Gly Arg Arg Trp Leu Val Leu Leu Leu Phe Ser Leu
  45                  50                  55                  60

 ctg gcg ttc gtt cag ggc ctg gtc tgg aac acc tgg ggt ccc atc cag      961
 Leu Ala Phe Val Gln Gly Leu Val Trp Asn Thr Trp Gly Pro Ile Gln
                  65                  70                  75

 aac tcg gcg cgc cag gcc tac ggc ttc tcc agc tgg gac atc gcg ctg     1009
 Asn Ser Ala Arg Gln Ala Tyr Gly Phe Ser Ser Trp Asp Ile Ala Leu
              80                  85                  90

 ctc gtg ctg tgg ggg ccc atc ggc ttc ctg ccc tgc ttc gcg ttc atg     1057
 Leu Val Leu Trp Gly Pro Ile Gly Phe Leu Pro Cys Phe Ala Phe Met
          95                 100                 105

 tgg ctc ctg gac aag aga ggt ctc cgg ata act gtg ctc ctg aca tcc     1105
 Trp Leu Leu Asp Lys Arg Gly Leu Arg Ile Thr Val Leu Leu Thr Ser
     110                 115                 120

 ttc ctt atg gtt ttg gga act ggt cta aga tgc ata cct ata tca gac     1153
 Phe Leu Met Val Leu Gly Thr Gly Leu Arg Cys Ile Pro Ile Ser Asp
 125                 130                 135                 140

 tta atc ctt aaa aga aga tta att cat gga gga cag atg tta aat gga     1201
 Leu Ile Leu Lys Arg Arg Leu Ile His Gly Gly Gln Met Leu Asn Gly
                 145                 150                 155

 ttg gca ggt cca act gta atg aat gca gca cca ttt ctc tct acg acg     1249
 Leu Ala Gly Pro Thr Val Met Asn Ala Ala Pro Phe Leu Ser Thr Thr
             160                 165                 170

 tgg ttt tct gca gat gaa agg gcc aca gcc aca gct att gca tca atg     1297
 Trp Phe Ser Ala Asp Glu Arg Ala Thr Ala Thr Ala Ile Ala Ser Met
         175                 180                 185

 ctc agt tat ctt ggg gga gca tgt gca ttt tta gtt gga cca ctt gtt     1345
 Leu Ser Tyr Leu Gly Gly Ala Cys Ala Phe Leu Val Gly Pro Leu Val
     190                 195                 200

 gtt cca gct ccc aat ggg aca tca cct ctt ctt gct gca gag agc agc     1393
 Val Pro Ala Pro Asn Gly Thr Ser Pro Leu Leu Ala Ala Glu Ser Ser
 205                 210                 215                 220

 agg gcg cat att aaa gat cgc ata gag gct gtg tta tat gca gaa ttt     1441
 Arg Ala His Ile Lys Asp Arg Ile Glu Ala Val Leu Tyr Ala Glu Phe
                 225                 230                 235

 gga gtt gtc tgc tta ata ttt tct gca aca cta gct tat ttc cca ccc     1489
 Gly Val Val Cys Leu Ile Phe Ser Ala Thr Leu Ala Tyr Phe Pro Pro
             240                 245                 250

 cga cct cct ctt cct ccc agt gtt gct gca gct agc cag cgg ctg agt     1537
 Arg Pro Pro Leu Pro Pro Ser Val Ala Ala Ala Ser Gln Arg Leu Ser
         255                 260                 265

 tat cgg aga agc gtt tgt aga tta tta agc aat ttt cga ttt ttg atg     1585
 Tyr Arg Arg Ser Val Cys Arg Leu Leu Ser Asn Phe Arg Phe Leu Met
     270                 275                 280

 att gct tta gca tat gcc ata cca ctt ggt gta ttt gct ggc tgg tct     1633
 Ile Ala Leu Ala Tyr Ala Ile Pro Leu Gly Val Phe Ala Gly Trp Ser
 285                 290                 295                 300

 gga gtt ctg gac tta att tta aca cca gcg cat gtc agc caa gta gat     1681
 Gly Val Leu Asp Leu Ile Leu Thr Pro Ala His Val Ser Gln Val Asp
                 305                 310                 315

 gct ggc tgg att gga ttt tgg tcc ata gtt gga ggc tgt gtt gtt gga     1729
 Ala Gly Trp Ile Gly Phe Trp Ser Ile Val Gly Gly Cys Val Val Gly
             320                 325                 330

 ata gct atg gca agg ttt gca gat ttt atc agg ggt atg ctg aaa cta     1777
 Ile Ala Met Ala Arg Phe Ala Asp Phe Ile Arg Gly Met Leu Lys Leu
         335                 340                 345

 att ctt ctc ctc ctg ttt tcg gga gct aca ctg tca tcc acg tgg ttc     1825
 Ile Leu Leu Leu Leu Phe Ser Gly Ala Thr Leu Ser Ser Thr Trp Phe
     350                 355                 360

 acc ctg acc tgt ttg aac agc atc aca cac cta cct tta acc aca gtg     1873
 Thr Leu Thr Cys Leu Asn Ser Ile Thr His Leu Pro Leu Thr Thr Val
 365                 370                 375                 380

 aca ttg tat gcc tcc tgt att ctc ctg gga gtg ttc ttg aat agc agc     1921
 Thr Leu Tyr Ala Ser Cys Ile Leu Leu Gly Val Phe Leu Asn Ser Ser
                 385                 390                 395

 gtg cct ata ttt ttt gag ctt ttt gtg gaa act gtc tac cca gtt cca     1969
 Val Pro Ile Phe Phe Glu Leu Phe Val Glu Thr Val Tyr Pro Val Pro
             400                 405                 410

 gaa gga att act tgt gga gtt gtc act ttt tta agt aat atg ttt atg     2017
 Glu Gly Ile Thr Cys Gly Val Val Thr Phe Leu Ser Asn Met Phe Met
         415                 420                 425

 gga gta ctt tta ttt ttt ctc aca ttt tat cat aca gag ttg tct tgg     2065
 Gly Val Leu Leu Phe Phe Leu Thr Phe Tyr His Thr Glu Leu Ser Trp
     430                 435                 440

 ttc aac tgg tgc ctt ccc ggg tcg tgt ttg ctc agt ctc ctc ctc att     2113
 Phe Asn Trp Cys Leu Pro Gly Ser Cys Leu Leu Ser Leu Leu Leu Ile
 445                 450                 455                 460

 ctg tgc ttc agg gaa tcc tat gac aga ctc tat ctt gat gtg gtt gtc     2161
 Leu Cys Phe Arg Glu Ser Tyr Asp Arg Leu Tyr Leu Asp Val Val Val
                 465                 470                 475

 tcc gtt taa tagcaca gacttgaagg agtttaaaag gaggctggaa atcaatactg     2217
 Ser Val 






      <210> 109
      <211> 2923
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (163)..(1821)

      <400> 109
 tgagaggccg cggcggcagg tccacctggg cttgcgaagg cacagattcc ccgtccacag     60

 ctcacgacca gatgcaccag caggagtcca catcgaggac gtcctccggg cactcccacg    120

 accaggtagt gaccaggagt taaactttgg gatgtgcccg tg   atg ttg gac cac     174
                                                  Met Leu Asp His
                                                    1

 aag gac tta gag gcc gaa atc cac ccc ttg aaa aat gaa gaa aga aaa      222
 Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn Glu Glu Arg Lys
   5                  10                  15                  20

 tcg cag gaa aat ctg gga aat cca tca aaa aat gag gat aac gtg aaa      270
 Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu Asp Asn Val Lys
                  25                  30                  35

 agc gcg cct cca cag tcc cgg ctc tcc cgg tgc cga gcg gcg gcg ttt      318
 Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg Ala Ala Ala Phe
              40                  45                  50

 ttt ctt tca ttg ttt ctc tgc ctt ttt gtg gtg ttc gtc gtc tca ttc      366
 Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe Val Val Ser Phe
          55                  60                  65

 gtc atc ccg tgt cca gac cgg ccg gcg tca cag cga atg tgg agg ata      414
 Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg Met Trp Arg Ile
      70                  75                  80

 gac tac agt gcc gct gtt atc tat gac ttt ctg gct gtg gat gat ata      462
 Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala Val Asp Asp Ile
  85                  90                  95                 100

 aac ggg gac agg atc caa gat gtt ctt ttt ctt tat aaa aac acc aac      510
 Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr Lys Asn Thr Asn
                 105                 110                 115

 agc agc aac aat ttc agc cga tcc tgt gtg gac gaa ggc ttt tcc tct      558
 Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu Gly Phe Ser Ser
             120                 125                 130

 ccc tgc acc ttt gca gct gct gtg tcg ggg gcc aac ggc agc acg ctc      606
 Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn Gly Ser Thr Leu
         135                 140                 145

 tgg gag aga cct gtg gcc caa gac gtg gcc ctc gtg gag tgt gct gtg      654
 Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val Glu Cys Ala Val
     150                 155                 160

 ccc cag cca aga ggc agt gag gca cct tct gcc tgc atc ctg gtg ggc      702
 Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys Ile Leu Val Gly
 165                 170                 175                 180

 aga ccc agt tct ttc att gca gtc aac ttg ttc aca ggg gaa acc ctg      750
 Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr Gly Glu Thr Leu
                 185                 190                 195

 tgg aac cac agc agc agc ttc agc ggg aat gcg tcc atc ctg agc cct      798
 Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser Ile Leu Ser Pro
             200                 205                 210

 ctg ctg cag gtg cct gat gtg gac ggc gat ggg gcc cca gac ctg ctg      846
 Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala Pro Asp Leu Leu
         215                 220                 225

 gtt ctc acc cag gag cgg gag gag gtt agt ggc cac ctc tac tcc ggc      894
 Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His Leu Tyr Ser Gly
     230                 235                 240

 agc acc ggg cac cag att ggc ctc aga ggc agc ctt ggt gtg gac ggg      942
 Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu Gly Val Asp Gly
 245                 250                 255                 260

 gaa agt ggc ttc ctc ctt cac gtc acc agg aca ggt gcc cac tac atc      990
 Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly Ala His Tyr Ile
                 265                 270                 275

 ctc ttt ccc tgc gca agc tcc ctc tgc ggc tgc tct gtg aag ggt ctc     1038
 Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser Val Lys Gly Leu
             280                 285                 290

 tac gag aag gtg acc ggg agc ggc ggc ccg ttc aag agt gac ccg cac     1086
 Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys Ser Asp Pro His
         295                 300                 305

 tgg gag agc atg ctc aat gcc acc acc cgc agg atg ctt tcc cac agc     1134
 Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met Leu Ser His Ser
     310                 315                 320

 tct gga gca gtg cgc tac ctg atg cat gtc cca ggg aac gcc ggt gca     1182
 Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly Asn Ala Gly Ala
 325                 330                 335                 340

 gat gtg ctt ctt gtg ggc tca gag gcc ttc gtg ctg ctg gac ggg cag     1230
 Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu Leu Asp Gly Gln
                 345                 350                 355

 gag ctg acg cct cgc tgg aca ccc aag gca gcc cat gtc ctg aga aaa     1278
 Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His Val Leu Arg Lys
             360                 365                 370

 ccc atc ttc ggc cgc tac aaa cca gac acc ttg gct gta gcc gtt gaa     1326
 Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala Val Ala Val Glu
         375                 380                 385

 aac gga act ggc acc gac aga cag atc ctg ttt ctg gac ctt ggc act     1374
 Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu Asp Leu Gly Thr
     390                 395                 400

 gga gcc gtc ctg tgt agc cta gcc ctc ccg agc ctc cct ggg ggt cca     1422
 Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu Pro Gly Gly Pro
 405                 410                 415                 420

 ctg tcc gcc agc ctg ccg acc gca gac cac cgc tca gcc ttc ttc ttc     1470
 Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser Ala Phe Phe Phe
                 425                 430                 435

 tgg ggc ctc cac gag ctg ggg agc acc agc gag acg gag acc ggg gag     1518
 Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr Glu Thr Gly Glu
             440                 445                 450

 gcc cgg cac agc ctg tac atg ttc cac ccc acc ctg ccg cgc gtg ctg     1566
 Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu Pro Arg Val Leu
         455                 460                 465

 ctg gag ctg gcc aat gtc tct acc cac att gtc gcc ttt gac gcc gtc     1614
 Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala Phe Asp Ala Val
     470                 475                 480

 ctg ttt gag cca agc cgc cac gcc gcc tac atc ctt ctg aca ggc ccg     1662
 Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu Leu Thr Gly Pro
 485                 490                 495                 500

 gca gac tca gag gca ccc ggc ctg gtc tct gtg atc aag cac aag gtg     1710
 Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile Lys His Lys Val
                 505                 510                 515

 cgg gac ctt gtc cca agc agc agg gtg gtc cgc ctg ggt gag ggt ggg     1758
 Arg Asp Leu Val Pro Ser Ser Arg Val Val Arg Leu Gly Glu Gly Gly
             520                 525                 530

 cca gac agt gac caa gcc atc agg gac cgg ttc tcc cgg ctg cgg tac     1806
 Pro Asp Ser Asp Gln Ala Ile Arg Asp Arg Phe Ser Arg Leu Arg Tyr
         535                 540                 545

 cag agt gag gcg tag aggcacgcca gccagagcct gtggagagac tccgcctgct     1861
 Gln Ser Glu Ala 
     550

 gacactaaac gtcctgggaa gtgggccctt ccctgggtct ctgcactgac tcccccactc   1921

 ctgaccctgg tgatggtcgc cactgggcag cagcagcctt accagtcctc catgatcaca   1981

 cccagggacc tgcatgggtg aggggacacc ctgggcctct ctcccgccca gcatcctccc   2041

 tgagtcccca cacagggcct cactctgcac cccaccaggg tcccgctcac accaggcagc   2101

 cttcatagtg gtctccctgg ccaccttggg cagagctggg tcatgcagca ccccatcctt   2161

 acccggtgcc ctctccttgc cagcttctcc ccaggccaga gcggccatcg cgtagaaaga   2221

 accagggtgt ccccgggaca ggccgtcccc caccccatcc tgtagaagtc cattcccctt   2281

 ttccctcctg tgctctgtcc cccaaggagt catggaactc agggtactgg gcctcaacgg   2341

 gaacctgaga cagctccagc ttcgcagccc ttcccggagc tacaggggga tcctctagca   2401

 tggggggtgt gacttggttc ctttgaccag gtcctgtgag gaagcctgga gcaagggtct   2461

 cccccagcag gatgggtggg gcctgctctg gagctgagcc cgtggccgct cacaggtgtc   2521

 cttagtggtg ttgcagctgt ctactggctg catgtgctgt gaatatccca aggaactggc   2581

 tgtggaatgc gtgtttgggt cagtctgtgc cctctcagta gacactggag ctgctctgtc   2641

 cctgaagagg ccccgtgccc caggcatggc aagcgcctgc ctctcccctt ccggtgctca   2701

 cacgcccacg ccgtgccacc cgatgcagga ctcacctctg tgccttgctg ctcctgaggc   2761

 ccaagggcag ccatggtgct ctgtactgct cgggccgccc aggtcacaga gcctgagctt   2821

 cgtagccaaa gcagcctgat gacccaccca ccaaggaaga aagcagaata aacatttttg   2881

 cactgcctga aaaaccccgg tggtcaggcg tgaaaaaaaa aa                      2923




      <210> 110
      <211> 2896
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (163)..(1794)

      <400> 110
 tgagaggccg cggcggcagg tccacctggg cttgcgaagg cacagattcc ccgtccacag     60

 ctcacgacca gatgcaccag caggagtcca catcgaggac gtcctccggg cactcccacg    120

 accaggtagt gaccaggagt taaactttgg gatgtgcccg tg   atg ttg gac cac     174
                                                  Met Leu Asp His
                                                    1

 aag gac tta gag gcc gaa atc cac ccc ttg aaa aat gaa gaa aga aaa      222
 Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn Glu Glu Arg Lys
   5                  10                  15                  20

 tcg cag gaa aat ctg gga aat cca tca aaa aat gag gat aac gtg aaa      270
 Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu Asp Asn Val Lys
                  25                  30                  35

 agc gcg cct cca cag tcc cgg ctc tcc cgg tgc cga gcg gcg gcg ttt      318
 Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg Ala Ala Ala Phe
              40                  45                  50

 ttt ctt tca ttg ttt ctc tgc ctt ttt gtg gtg ttc gtc gtc tca ttc      366
 Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe Val Val Ser Phe
          55                  60                  65

 gtc atc ccg tgt cca gac cgg ccg gcg tca cag cga atg tgg agg ata      414
 Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg Met Trp Arg Ile
      70                  75                  80

 gac tac agt gcc gct gtt atc tat gac ttt ctg gct gtg gat gat ata      462
 Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala Val Asp Asp Ile
  85                  90                  95                 100

 aac ggg gac agg atc caa gat gtt ctt ttt ctt tat aaa aac acc aac      510
 Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr Lys Asn Thr Asn
                 105                 110                 115

 agc agc aac aat ttc agc cga tcc tgt gtg gac gaa gct gct gtg tcg      558
 Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu Ala Ala Val Ser
             120                 125                 130

 ggg gcc aac ggc agc acg ctc tgg gag aga cct gtg gcc caa gac gtg      606
 Gly Ala Asn Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val
         135                 140                 145

 gcc ctc gtg gag tgt gct gtg ccc cag cca aga ggc agt gag gca cct      654
 Ala Leu Val Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro
     150                 155                 160

 tct gcc tgc atc ctg gtg ggc aga ccc agt tct ttc att gca gtc aac      702
 Ser Ala Cys Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn
 165                 170                 175                 180

 ttg ttc aca ggg gaa acc ctg tgg aac cac agc agc agc ttc agc ggg      750
 Leu Phe Thr Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly
                 185                 190                 195

 aat gcg tcc atc ctg agc cct ctg ctg cag gtg cct gat gtg gac ggc      798
 Asn Ala Ser Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly
             200                 205                 210

 gat ggg gcc cca gac ctg ctg gtt ctc acc cag gag cgg gag gag gtt      846
 Asp Gly Ala Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val
         215                 220                 225

 agt ggc cac ctc tac tcc ggc agc acc ggg cac cag att ggc ctc aga      894
 Ser Gly His Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg
     230                 235                 240

 ggc agc ctt ggt gtg gac ggg gaa agt ggc ttc ctc ctt cac gtc acc      942
 Gly Ser Leu Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr
 245                 250                 255                 260

 agg aca ggt gcc cac tac atc ctc ttt ccc tgc gca agc tcc ctc tgc      990
 Arg Thr Gly Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys
                 265                 270                 275

 ggc tgc tct gtg aag ggt ctc tac gag aag gtg acc ggg agc ggc ggc     1038
 Gly Cys Ser Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly
             280                 285                 290

 ccg ttc aag agt gac ccg cac tgg gag agc atg ctc aat gcc acc acc     1086
 Pro Phe Lys Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr
         295                 300                 305

 cgc agg atg ctt tcc cac agc tct gga gca gtg cgc tac ctg atg cat     1134
 Arg Arg Met Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His
     310                 315                 320

 gtc cca ggg aac gcc ggt gca gat gtg ctt ctt gtg ggc tca gag gcc     1182
 Val Pro Gly Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala
 325                 330                 335                 340

 ttc gtg ctg ctg gac ggg cag gag ctg acg cct cgc tgg aca ccc aag     1230
 Phe Val Leu Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys
                 345                 350                 355

 gca gcc cat gtc ctg aga aaa ccc atc ttc ggc cgc tac aaa cca gac     1278
 Ala Ala His Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp
             360                 365                 370

 acc ttg gct gta gcc gtt gaa aac gga act ggc acc gac aga cag atc     1326
 Thr Leu Ala Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile
         375                 380                 385

 ctg ttt ctg gac ctt ggc act gga gcc gtc ctg tgt agc cta gcc ctc     1374
 Leu Phe Leu Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu
     390                 395                 400

 ccg agc ctc cct ggg ggt cca ctg tcc gcc agc ctg ccg acc gca gac     1422
 Pro Ser Leu Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp
 405                 410                 415                 420

 cac cgc tca gcc ttc ttc ttc tgg ggc ctc cac gag ctg ggg agc acc     1470
 His Arg Ser Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr
                 425                 430                 435

 agc gag acg gag acc ggg gag gcc cgg cac agc ctg tac atg ttc cac     1518
 Ser Glu Thr Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His
             440                 445                 450

 ccc acc ctg ccg cgc gtg ctg ctg gag ctg gcc aat gtc tct acc cac     1566
 Pro Thr Leu Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His
         455                 460                 465

 att gtc gcc ttt gac gcc gtc ctg ttt gag cca agc cgc cac gcc gcc     1614
 Ile Val Ala Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala
     470                 475                 480

 tac atc ctt ctg aca ggc ccg gca gac tca gag gca ccc ggc ctg gtc     1662
 Tyr Ile Leu Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val
 485                 490                 495                 500

 tct gtg atc aag cac aag gtg cgg gac ctt gtc cca agc agc agg gtg     1710
 Ser Val Ile Lys His Lys Val Arg Asp Leu Val Pro Ser Ser Arg Val
                 505                 510                 515

 gtc cgc ctg ggt gag ggt ggg cca gac agt gac caa gcc atc agg gac     1758
 Val Arg Leu Gly Glu Gly Gly Pro Asp Ser Asp Gln Ala Ile Arg Asp
             520                 525                 530

 cgg ttc tcc cgg ctg cgg tac cag agt gag gcg tag aggc acgccagcca     1808
 Arg Phe Ser Arg Leu Arg Tyr Gln Ser Glu Ala 
         535                 540

 gagcctgtgg agagactccg cctgctgaca ctaaacgtcc tgggaagtgg gcccttccct   1868

 gggtctctgc actgactccc ccactcctga ccctggtgat ggtcgccact gggcagcagc   1928

 agccttacca gtcctccatg atcacaccca gggacctgca tgggtgaggg gacaccctgg   1988

 gcctctctcc cgcccagcat cctccctgag tccccacaca gggcctcact ctgcacccca   2048

 ccagggtccc gctcacacca ggcagccttc atagtggtct ccctggccac cttgggcaga   2108

 gctgggtcat gcagcacccc atccttaccc ggtgccctct ccttgccagc ttctccccag   2168

 gccagagcgg ccatcgcgta gaaagaacca gggtgtcccc gggacaggcc gtcccccacc   2228

 ccatcctgta gaagtccatt ccccttttcc ctcctgtgct ctgtccccca aggagtcatg   2288

 gaactcaggg tactgggcct caacgggaac ctgagacagc tccagcttcg cagcccttcc   2348

 cggagctaca gggggatcct ctagcatggg gggtgtgact tggttccttt gaccaggtcc   2408

 tgtgaggaag cctggagcaa gggtctcccc cagcaggatg ggtggggcct gctctggagc   2468

 tgagcccgtg gccgctcaca ggtgtcctta gtggtgttgc agctgtctac tggctgcatg   2528

 tgctgtgaat atcccaagga actggctgtg gaatgcgtgt ttgggtcagt ctgtgccctc   2588

 tcagtagaca ctggagctgc tctgtccctg aagaggcccc gtgccccagg catggcaagc   2648

 gcctgcctct ccccttccgg tgctcacacg cccacgccgt gccacccgat gcaggactca   2708

 cctctgtgcc ttgctgctcc tgaggcccaa gggcagccat ggtgctctgt actgctcggg   2768

 ccgcccaggt cacagagcct gagcttcgta gccaaagcag cctgatgacc cacccaccaa   2828

 ggaagaaagc agaataaaca tttttgcact gcctgaaaaa ccccggtggt caggcgtgaa   2888

 aaaaaaaa                                                            2896




      <210> 111
      <211> 2446
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (452)..(775)

      <400> 111
 gggtattgag gcagaagaaa actttgaaga agactcacac aggccattaa ttaatggtgg     60

 tgaaaatgaa gacgaatatg agccgaatta ttcaatccaa gatgatagtt ctgttgccca    120

 agtcaaggcg ataagcttct accaggcatg ttgccttcct ggagtcatac cgtactcact    180

 ggcctacgcc tgcttgaagt tagtgaatta ctccttcttc ttctggctcc ccttttatct    240

 gagtaacaac ttcggctgga aggaggcgga agccgacaag ctgtccattt ggtacgacgt    300

 tggagggatc ataggtggaa ctttgcaagg cttcatctct gatgtactac agaagagagc    360

 gccggttctt gccctgagtc tgcttctggc agttgggtcc ctcatcgggt atagtcgttc    420

 tccaaatgat aagtccatca atgcccttct g   atg act gtt aca gga ttt ttt     472
                                      Met Thr Val Thr Gly Phe Phe
                                        1               5

 att ggt gga cct tct aat atg att agt tct gct att tct gcg gac ttg      520
 Ile Gly Gly Pro Ser Asn Met Ile Ser Ser Ala Ile Ser Ala Asp Leu
          10                  15                  20

 ggt cgc cag gag ctc atc caa agg agc agt gaa gct ttg gcc act gtc      568
 Gly Arg Gln Glu Leu Ile Gln Arg Ser Ser Glu Ala Leu Ala Thr Val
      25                  30                  35

 aca gga att gtg gat ggt tcg ggg agc att gga gct gca gtg ggc cag      616
 Thr Gly Ile Val Asp Gly Ser Gly Ser Ile Gly Ala Ala Val Gly Gln
  40                  45                  50                  55

 tat tta gtg tct ctg atc cgg gac aag cta gga tgg atg tgg gtt ttc      664
 Tyr Leu Val Ser Leu Ile Arg Asp Lys Leu Gly Trp Met Trp Val Phe
                  60                  65                  70

 tac ttt ttc att ctc atg aca agt tgt aca att gtg ttt atc tcg cca      712
 Tyr Phe Phe Ile Leu Met Thr Ser Cys Thr Ile Val Phe Ile Ser Pro
              75                  80                  85

 tta ata gtg agg gaa ata ttc tct ctc gtg cta agg aga cag gct cac      760
 Leu Ile Val Arg Glu Ile Phe Ser Leu Val Leu Arg Arg Gln Ala His
          90                  95                 100

 ata ttg agg gag tga ccggtgcccg cgagacagaa agaacaatgt cagccacatc      815
 Ile Leu Arg Glu 
     105

 aggaccgctg gggcttcgag tctgccctaa tttgggtttg tctaggagct ccagcctgat    875

 cttggattgt caggcgtctc tcaacactgc cagccacctg agatgctgac cagcagtgaa    935

 ggctgcacta gttttctaca ctacaggaat tactgttgat gatttttgct gttgtttcat    995

 gaatgtgccg agtgacttct gactctgcca gcatctttga cctctgactc tgcccgcgtc   1055

 tttgtttggc ctattgaggt ttagcgtttt aaccttaact gttgttttgg acttgaactt   1115

 tctctagcct tgaaaatgga gtgaacagga ggcaaagcca cgcgtggttt gtgttggtgg   1175

 tatgttccac aaatggaaga gatcattgca ttttgctttg gtaatgagtt tacagagagt   1235

 gggtcatctt tgaagcatca aatcctgatc aaatgctcaa gctggaccga gctgcaagcc   1295

 tgccttggac aaagaatccc tctgttcact gtggtgggaa agatcacact acatgcctgt   1355

 tgattggctc agtcactctg tgtctgatct aaacgtcatt cagccctaga agcatgaatt   1415

 gcttcaaatt attgtcaact tgttctcttc cattttcatt caaattaact ttgactcctg   1475

 gaagtattga gtcttccttt caaggaccat aaggtacatc agttatcttg aacattctga   1535

 cgtgtaaagg accataaggt acatcattta tcttgaacat tccgacgtgt aactcacagc   1595

 cgaagcactc catcccagat ttgttgtctg ggaactttag gatcctctag gaagctaatc   1655

 tgcttagtct atttttagag gattgatctc tggcacaacc agcttcctgg agttacctca   1715

 gcagaagact agaattagag aaaagggaaa gaccttttct tctagtaagt gtcaagtaca   1775

 gatgctcttt gacttatgat ggggttatgt cccagtaaac ccattggaag tcaaatgcat   1835

 ttaatacccc tgactggaca ccacagctta gcctcgtcca ccctaaatgt actcagaaca   1895

 cttagaattg cccacagttg ggcagaatca tctaacacaa actctatttt ataatcgagt   1955

 gttgaatata tcatgtaatt tattgaatat tgtacattat gttgaaattg caaccatttc   2015

 acaccattgt aaagtccaaa aatcagaagc tgaggactgt ctgtacatga cattgaatca   2075

 catgaatgga ttactagggc ctgaggggtg tccgttcttt agaaaaatgt agagtatata   2135

 tatcttcagg gctgtgaatt ccatactagt tatcaatatt ttaagatcat tctgtatata   2195

 catattttaa attatgcaag caaactagga ggagaatgtg caattttgag ggatacctaa   2255

 tttgcattcg gttaggggat atttttcaac ctcttgcttt atactctgat atggggtgtg   2315

 tttatgaact tgttaatgtt atttaatcat gcagatttcc agtcagtgta ttgctcattt   2375

 actgacaaaa agggaaaata cgaaacacag aaagggaaaa taaactgact tttataatga   2435

 aaaaaaaaaa a                                                        2446




      <210> 112
      <211> 1652
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(1602)

      <400> 112
 tcgcgatcta gaactagtcc agacctcccg gctactcaga agccctcgga ctgcccggac     60

 cgcgcg   atg gag tcg acc ggc agc gtc ggg gag gcc ccg ggc gga ccc     108
          Met Glu Ser Thr Gly Ser Val Gly Glu Ala Pro Gly Gly Pro
            1               5                  10

 cgg gtg ctg gtg gtg ggc ggc ggc atc gcg ggg ctg ggc gcg gcg cag      156
 Arg Val Leu Val Val Gly Gly Gly Ile Ala Gly Leu Gly Ala Ala Gln
  15                  20                  25                  30

 agg ctc tgc ggc cac tcc gcc ttc ccg cac ctg cgg gtc ctg gag gcc      204
 Arg Leu Cys Gly His Ser Ala Phe Pro His Leu Arg Val Leu Glu Ala
                  35                  40                  45

 acg gcc cgc gcc ggg ggc cgc atc cgc tcg gag cgc tgc ttc ggt ggc      252
 Thr Ala Arg Ala Gly Gly Arg Ile Arg Ser Glu Arg Cys Phe Gly Gly
              50                  55                  60

 gtg gtg gag gtg ggc gcg cac tgg atc cat ggg ccc tcc cgg ggt aac      300
 Val Val Glu Val Gly Ala His Trp Ile His Gly Pro Ser Arg Gly Asn
          65                  70                  75

 ccc gtc ttc cag ctg gct gct gag tac ggg ctg ctg ggg gag aag gag      348
 Pro Val Phe Gln Leu Ala Ala Glu Tyr Gly Leu Leu Gly Glu Lys Glu
      80                  85                  90

 ctg tcc cag gag aac cag ctg gtg gag acc ggg ggt cac gtg ggc ctg      396
 Leu Ser Gln Glu Asn Gln Leu Val Glu Thr Gly Gly His Val Gly Leu
  95                 100                 105                 110

 ccc tcc gtg agc tac gcc agc tcc ggg gcc agc gtg agc ctc cag ctg      444
 Pro Ser Val Ser Tyr Ala Ser Ser Gly Ala Ser Val Ser Leu Gln Leu
                 115                 120                 125

 gtg gcg gag atg gcg act ctg ttc tac ggc ctg ata gac cag acc cgg      492
 Val Ala Glu Met Ala Thr Leu Phe Tyr Gly Leu Ile Asp Gln Thr Arg
             130                 135                 140

 gag ttc ctg cac gct gca gag acc ccg gtg ccc agc gtc ggg gag tac      540
 Glu Phe Leu His Ala Ala Glu Thr Pro Val Pro Ser Val Gly Glu Tyr
         145                 150                 155

 ctc aag aag gag att ggc cag cac gtg gcc ggc tgg aca gag gat gag      588
 Leu Lys Lys Glu Ile Gly Gln His Val Ala Gly Trp Thr Glu Asp Glu
     160                 165                 170

 gag acc agg aag ctg aag ctg gcc gtc ctg aac tcc ttc ttc aac ctg      636
 Glu Thr Arg Lys Leu Lys Leu Ala Val Leu Asn Ser Phe Phe Asn Leu
 175                 180                 185                 190

 gaa tgc tgt gtg agc ggc acc cac agc atg gac ctg gtg gcc ctg gca      684
 Glu Cys Cys Val Ser Gly Thr His Ser Met Asp Leu Val Ala Leu Ala
                 195                 200                 205

 ccc ttt ggg gag tat acc gtg ctg ccg ggg ctg gac tgc acc ttt tct      732
 Pro Phe Gly Glu Tyr Thr Val Leu Pro Gly Leu Asp Cys Thr Phe Ser
             210                 215                 220

 aag ggc tat caa gga ctc aca aac tgc atg atg gcc gcc ctg ccg gag      780
 Lys Gly Tyr Gln Gly Leu Thr Asn Cys Met Met Ala Ala Leu Pro Glu
         225                 230                 235

 gac act gta gtt ttt gag aag cct gtg aag acc atc cac tgg aac ggg      828
 Asp Thr Val Val Phe Glu Lys Pro Val Lys Thr Ile His Trp Asn Gly
     240                 245                 250

 tcc ttc cag gag gca gcc ttt ccc ggg gag acc ttt cca gtg tcg gta      876
 Ser Phe Gln Glu Ala Ala Phe Pro Gly Glu Thr Phe Pro Val Ser Val
 255                 260                 265                 270

 gag tgt gag gat gga gac cgg ttc ccg gcg cac cat gtc atc gtc acc      924
 Glu Cys Glu Asp Gly Asp Arg Phe Pro Ala His His Val Ile Val Thr
                 275                 280                 285

 gtg ccc tta ggt ttt ctt agg gaa cat ttg gac acc ttc ttt gac cct      972
 Val Pro Leu Gly Phe Leu Arg Glu His Leu Asp Thr Phe Phe Asp Pro
             290                 295                 300

 ccc ctg ccg gct gag aag gca gaa gca atc agg aag ata ggc ttt ggg     1020
 Pro Leu Pro Ala Glu Lys Ala Glu Ala Ile Arg Lys Ile Gly Phe Gly
         305                 310                 315

 acc aac aac aaa atc ttc ctg gag ttt gag gag ccc ttc tgg gag cca     1068
 Thr Asn Asn Lys Ile Phe Leu Glu Phe Glu Glu Pro Phe Trp Glu Pro
     320                 325                 330

 gac tgc cag ctg atc cag ctg gtg tgg gag gac acg tcg ccc ctg gag     1116
 Asp Cys Gln Leu Ile Gln Leu Val Trp Glu Asp Thr Ser Pro Leu Glu
 335                 340                 345                 350

 gat gct gcc cct gag cta cag gac gcc tgg ttc cgg aag ctc att ggc     1164
 Asp Ala Ala Pro Glu Leu Gln Asp Ala Trp Phe Arg Lys Leu Ile Gly
                 355                 360                 365

 ttt gtg gtc ctg cct gcc ttt gcg tct gtc cac gtt ctc tgt ggg ttc     1212
 Phe Val Val Leu Pro Ala Phe Ala Ser Val His Val Leu Cys Gly Phe
             370                 375                 380

 att gcc gga ctt gag tct gag ttc atg gag act ctg tcg gat gaa gaa     1260
 Ile Ala Gly Leu Glu Ser Glu Phe Met Glu Thr Leu Ser Asp Glu Glu
         385                 390                 395

 gta ctt ctg tgt ctc acc caa gtg ctc cgg aga gtg aca gga aac cca     1308
 Val Leu Leu Cys Leu Thr Gln Val Leu Arg Arg Val Thr Gly Asn Pro
     400                 405                 410

 cgg ctc ccc gcg ccc aag agc gtc ctg cgg tct cgc tgg cac agc gcc     1356
 Arg Leu Pro Ala Pro Lys Ser Val Leu Arg Ser Arg Trp His Ser Ala
 415                 420                 425                 430

 ccg tac act agg ggg tcc tac agc tac gtg gcc gtg ggc agt act ggg     1404
 Pro Tyr Thr Arg Gly Ser Tyr Ser Tyr Val Ala Val Gly Ser Thr Gly
                 435                 440                 445

 ggc gac ctg gac ctg ctg gct cag ccc ctc cct gca gac ggc gcc ggc     1452
 Gly Asp Leu Asp Leu Leu Ala Gln Pro Leu Pro Ala Asp Gly Ala Gly
             450                 455                 460

 gcc cag ctc cag atc ctg ttt gcg ggg gaa gcc aca cat cgc acg ttt     1500
 Ala Gln Leu Gln Ile Leu Phe Ala Gly Glu Ala Thr His Arg Thr Phe
         465                 470                 475

 tac tcc acg acg cac ggg gct ctg ctg tcg gga tgg agg gag gcc gac     1548
 Tyr Ser Thr Thr His Gly Ala Leu Leu Ser Gly Trp Arg Glu Ala Asp
     480                 485                 490

 cgc ctc ctc agt ctg tgg gcc ccg cag gtg cag cag ccc agg ccg agg     1596
 Arg Leu Leu Ser Leu Trp Ala Pro Gln Val Gln Gln Pro Arg Pro Arg
 495                 500                 505                 510

 ctc tag ctgggcccag cctactctgt tccacccgtg tcgggggtag gctgggaccg      1652
 Leu 






      <210> 113
      <211> 5387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (615)..(4538)

      <400> 113
 ttcctagttg ttacaacagg tggtgtccct tgttacttca ccgtggttcg aagcagaaga     60

 ctctttagct attacagaga agtggatatg ctcttcgtca tcttaaatat tcaggccctc    120

 cctaaaggag tctcaatccc gggggagtgg cagttgcggg cgaccaagca gtcaccggct    180

 gcgctgcggc gacctcccgg gaagctgcgg ccggcggggt ccgaagagca tcacgtcatc    240

 ctttccccca ggagcccgcc ccctcccata cagcgcctgc gcatgcgcgg taggaggagg    300

 gtcacggtgg gggctgtcca cgcgctctcc gcccttctcc aggctcgctc gggccgcggc    360

 gctctcggct agctgcagcg gcggcggcgc ggaggggaag gcatccagga tgcggtgcgg    420

 ggcggcccgg tgcccccccg ccccgtcacg gcagccgcgg cggccgaggg gaccgggcca    480

 gggccggggg cggcggcccg agccgcggta gcggcggcgg cgggaggggc ggcctgaggg    540

 cggacgggcg ggcgcccggg ttgcgggggc tcggtgccgc tccgcactgc ccggccggtc    600

 tcggccccgg cgcc  atg agt ggc ggc ggc ggc gga ggg ggc tcg gcg ccc     650
                  Met Ser Gly Gly Gly Gly Gly Gly Gly Ser Ala Pro
                    1               5                  10

 agt cgc ttc gcc gac tac ttt gtc atc tgc gga ctg gac acg gag acc      698
 Ser Arg Phe Ala Asp Tyr Phe Val Ile Cys Gly Leu Asp Thr Glu Thr
          15                  20                  25

 ggg ctg gag ccg gac gag ctg tcg gca tta tgc cag tac ata cag gct      746
 Gly Leu Glu Pro Asp Glu Leu Ser Ala Leu Cys Gln Tyr Ile Gln Ala
      30                  35                  40

 tct aaa gcc agg gat ggt gcc agc cct ttc att tca agt acg act gaa      794
 Ser Lys Ala Arg Asp Gly Ala Ser Pro Phe Ile Ser Ser Thr Thr Glu
  45                  50                  55                  60

 gga gaa aat ttt gag cag aca cca ttg aga aga aca ttc aaa tct aag      842
 Gly Glu Asn Phe Glu Gln Thr Pro Leu Arg Arg Thr Phe Lys Ser Lys
                  65                  70                  75

 gtc ctt gca cga tat cct gag aac gta gaa tgg aat ccc ttt gac caa      890
 Val Leu Ala Arg Tyr Pro Glu Asn Val Glu Trp Asn Pro Phe Asp Gln
              80                  85                  90

 gat gca gta gga atg cta tgt atg ccg aaa ggg ctg gca ttc aag acc      938
 Asp Ala Val Gly Met Leu Cys Met Pro Lys Gly Leu Ala Phe Lys Thr
          95                 100                 105

 cag gct gat ccc agg gag ccc caa ttc cat gcc ttt att atc aca agg      986
 Gln Ala Asp Pro Arg Glu Pro Gln Phe His Ala Phe Ile Ile Thr Arg
     110                 115                 120

 gag gat ggc tct cgg aca ttt ggg ttt gcc ctc aca ttt tat gaa gag     1034
 Glu Asp Gly Ser Arg Thr Phe Gly Phe Ala Leu Thr Phe Tyr Glu Glu
 125                 130                 135                 140

 gtg act agc aag cag atc tgc agt gca atg cag acc ctc tac cac atg     1082
 Val Thr Ser Lys Gln Ile Cys Ser Ala Met Gln Thr Leu Tyr His Met
                 145                 150                 155

 cac aat gct gag tat gat gtc cta cat gct ccc cct gct gat gac aga     1130
 His Asn Ala Glu Tyr Asp Val Leu His Ala Pro Pro Ala Asp Asp Arg
             160                 165                 170

 gac cag agc agc atg gag gat ggt gaa gac act cct gtg acc aaa ctg     1178
 Asp Gln Ser Ser Met Glu Asp Gly Glu Asp Thr Pro Val Thr Lys Leu
         175                 180                 185

 cag cgc ttc aac tcc tat gac att agc cgg gac act ctc tac gtc tct     1226
 Gln Arg Phe Asn Ser Tyr Asp Ile Ser Arg Asp Thr Leu Tyr Val Ser
     190                 195                 200

 aag tgc atc tgc ctc atc aca ccc atg tct ttc atg aag gca tgt cgg     1274
 Lys Cys Ile Cys Leu Ile Thr Pro Met Ser Phe Met Lys Ala Cys Arg
 205                 210                 215                 220

 agc gtg ctg cag caa ctc cac cag gca gtc act tca cct cag ccc cct     1322
 Ser Val Leu Gln Gln Leu His Gln Ala Val Thr Ser Pro Gln Pro Pro
                 225                 230                 235

 cca ctg ccc ctt gag agc tac ata tac aac gta ctc tac gag gtg ccg     1370
 Pro Leu Pro Leu Glu Ser Tyr Ile Tyr Asn Val Leu Tyr Glu Val Pro
             240                 245                 250

 ctc cca cct cct ggc cgg tcc ttg aag ttt tct ggg gtc tat ggg cca     1418
 Leu Pro Pro Pro Gly Arg Ser Leu Lys Phe Ser Gly Val Tyr Gly Pro
         255                 260                 265

 ata atc tgc cag aga cca agt acc aat gag ctt ccc cta ttt gac ttt     1466
 Ile Ile Cys Gln Arg Pro Ser Thr Asn Glu Leu Pro Leu Phe Asp Phe
     270                 275                 280

 cct gtc aaa gag gtt ttt gaa ctg ctc ggg gtg gag aat gtg ttt cag     1514
 Pro Val Lys Glu Val Phe Glu Leu Leu Gly Val Glu Asn Val Phe Gln
 285                 290                 295                 300

 ctt ttt act tgt gcc ctt ctg gag ttt caa atc ctg ctc tac tca cag     1562
 Leu Phe Thr Cys Ala Leu Leu Glu Phe Gln Ile Leu Leu Tyr Ser Gln
                 305                 310                 315

 cat tac cag aga ctg atg act gtg gcg gag acg att aca gct ctc atg     1610
 His Tyr Gln Arg Leu Met Thr Val Ala Glu Thr Ile Thr Ala Leu Met
             320                 325                 330

 ttt cct ttc cag tgg cag cat gtc tat gtc cct att ctc cca gct tct     1658
 Phe Pro Phe Gln Trp Gln His Val Tyr Val Pro Ile Leu Pro Ala Ser
         335                 340                 345

 ctc ctg cat ttc tta gat gct cct gtt cca tac ctg atg ggt ttg cat     1706
 Leu Leu His Phe Leu Asp Ala Pro Val Pro Tyr Leu Met Gly Leu His
     350                 355                 360

 tcc aat ggc ctg gat gac cgg tca aag ctg gag ctg cct caa gag gct     1754
 Ser Asn Gly Leu Asp Asp Arg Ser Lys Leu Glu Leu Pro Gln Glu Ala
 365                 370                 375                 380

 aac ctc tgc ttt gtg gac att gac aac cac ttc att gag ttg cca gag     1802
 Asn Leu Cys Phe Val Asp Ile Asp Asn His Phe Ile Glu Leu Pro Glu
                 385                 390                 395

 gac ttg cca cag ttc ccc aac aaa ttg gag ttt gtc cag gaa gtc tct     1850
 Asp Leu Pro Gln Phe Pro Asn Lys Leu Glu Phe Val Gln Glu Val Ser
             400                 405                 410

 gag att ctc atg gca ttt gga att ccc cct gaa ggg aat ctt cat tgc     1898
 Glu Ile Leu Met Ala Phe Gly Ile Pro Pro Glu Gly Asn Leu His Cys
         415                 420                 425

 agt gag agt gcc tcc aag ctg aag agg ctg cgg gcc tct gag ctt gtc     1946
 Ser Glu Ser Ala Ser Lys Leu Lys Arg Leu Arg Ala Ser Glu Leu Val
     430                 435                 440

 tcg gac aag agg aat ggg aac att gct ggc tcc cct ttg cat tcc tac     1994
 Ser Asp Lys Arg Asn Gly Asn Ile Ala Gly Ser Pro Leu His Ser Tyr
 445                 450                 455                 460

 gag ctt ctt aag gag aat gaa act att gcc cgg ctg caa gcc ttg gtc     2042
 Glu Leu Leu Lys Glu Asn Glu Thr Ile Ala Arg Leu Gln Ala Leu Val
                 465                 470                 475

 aag aga act ggg gtg agc ctg gaa aag ttg gaa gtg cgt gaa gac ccc     2090
 Lys Arg Thr Gly Val Ser Leu Glu Lys Leu Glu Val Arg Glu Asp Pro
             480                 485                 490

 agc agc aat aag gat ctc aaa gtt cag tgt gat gaa gaa gaa ctc agg     2138
 Ser Ser Asn Lys Asp Leu Lys Val Gln Cys Asp Glu Glu Glu Leu Arg
         495                 500                 505

 att tac cag cta aac att cag atc cgg gaa gtt ttt gca aat cgt ttc     2186
 Ile Tyr Gln Leu Asn Ile Gln Ile Arg Glu Val Phe Ala Asn Arg Phe
     510                 515                 520

 act cag atg ttt gca gat tat gag gtg ttt gtc atc caa ccc agc cag     2234
 Thr Gln Met Phe Ala Asp Tyr Glu Val Phe Val Ile Gln Pro Ser Gln
 525                 530                 535                 540

 gat aag gaa tcc tgg ttt acc aac agg gag caa atg caa aac ttt gat     2282
 Asp Lys Glu Ser Trp Phe Thr Asn Arg Glu Gln Met Gln Asn Phe Asp
                 545                 550                 555

 aaa gca tct ttt ctg tca gat cag cct gag ccc tac ctg ccc ttc ctc     2330
 Lys Ala Ser Phe Leu Ser Asp Gln Pro Glu Pro Tyr Leu Pro Phe Leu
             560                 565                 570

 tca aga ttc ctg gag acc cag atg ttt gca tct ttc att gac aac aaa     2378
 Ser Arg Phe Leu Glu Thr Gln Met Phe Ala Ser Phe Ile Asp Asn Lys
         575                 580                 585

 ata atg tgt cat gat gat gat gat aaa gac cct gta ctc cgg gta ttt     2426
 Ile Met Cys His Asp Asp Asp Asp Lys Asp Pro Val Leu Arg Val Phe
     590                 595                 600

 gat tcc cga gtt gac aag atc agg ctg ttg aat gtt cgg aca cct act     2474
 Asp Ser Arg Val Asp Lys Ile Arg Leu Leu Asn Val Arg Thr Pro Thr
 605                 610                 615                 620

 ctc cgt aca tcc atg tac cag aag tgt acc act gtg gat gaa gca gag     2522
 Leu Arg Thr Ser Met Tyr Gln Lys Cys Thr Thr Val Asp Glu Ala Glu
                 625                 630                 635

 aaa gca att gag ctg cgt ctg gca aaa att gac cat act gca att cac     2570
 Lys Ala Ile Glu Leu Arg Leu Ala Lys Ile Asp His Thr Ala Ile His
             640                 645                 650

 cca cat tta ctt gac atg aag att gga caa ggg aaa tat gag ccg ggc     2618
 Pro His Leu Leu Asp Met Lys Ile Gly Gln Gly Lys Tyr Glu Pro Gly
         655                 660                 665

 ttc ttc cct aag ctg cag tct gat gta ctt tcc act ggg cca gcc agc     2666
 Phe Phe Pro Lys Leu Gln Ser Asp Val Leu Ser Thr Gly Pro Ala Ser
     670                 675                 680

 aac aag tgg acg aaa agg aat gcc cct gcc cag tgg agg cgg aaa gat     2714
 Asn Lys Trp Thr Lys Arg Asn Ala Pro Ala Gln Trp Arg Arg Lys Asp
 685                 690                 695                 700

 cgg cag aag cag cac aca gaa cac ctg cgt tta gat aat gac cag agg     2762
 Arg Gln Lys Gln His Thr Glu His Leu Arg Leu Asp Asn Asp Gln Arg
                 705                 710                 715

 gag aag tac atc cag gaa gcc agg act atg ggc agc act atc cgc cag     2810
 Glu Lys Tyr Ile Gln Glu Ala Arg Thr Met Gly Ser Thr Ile Arg Gln
             720                 725                 730

 ccc aaa ctg tcc aac ctc tct cca tca gtg att gcc cag acc aat tgg     2858
 Pro Lys Leu Ser Asn Leu Ser Pro Ser Val Ile Ala Gln Thr Asn Trp
         735                 740                 745

 aag ttt gta gag ggc ctg ctg aag gaa tgc cgc aat aag acc aag agg     2906
 Lys Phe Val Glu Gly Leu Leu Lys Glu Cys Arg Asn Lys Thr Lys Arg
     750                 755                 760

 atg ctg gtg gaa aag atg ggc cga gaa gct gtg gag cta ggg cat ggg     2954
 Met Leu Val Glu Lys Met Gly Arg Glu Ala Val Glu Leu Gly His Gly
 765                 770                 775                 780

 gag gtg aac atc aca ggg gtg gaa gag aac acc ctg att gcc agc ctt     3002
 Glu Val Asn Ile Thr Gly Val Glu Glu Asn Thr Leu Ile Ala Ser Leu
                 785                 790                 795

 tgt gat ctc ctg gaa agg atc tgg agt cat gga cta caa gtg aaa cag     3050
 Cys Asp Leu Leu Glu Arg Ile Trp Ser His Gly Leu Gln Val Lys Gln
             800                 805                 810

 ggg aaa tca gcc tta tgg tcc cac ctg tta cat tat cag gac aac cgg     3098
 Gly Lys Ser Ala Leu Trp Ser His Leu Leu His Tyr Gln Asp Asn Arg
         815                 820                 825

 cag aga aaa ctc aca tca gga agc ctc agt acc tca gga ata ctt ctt     3146
 Gln Arg Lys Leu Thr Ser Gly Ser Leu Ser Thr Ser Gly Ile Leu Leu
     830                 835                 840

 gat tca gaa cgt agg aag tct gat gcc agc tca ctc atg cct ccc ctg     3194
 Asp Ser Glu Arg Arg Lys Ser Asp Ala Ser Ser Leu Met Pro Pro Leu
 845                 850                 855                 860

 agg atc tcc ctg att cag gat atg agg cac atc cag aac atc ggg gaa     3242
 Arg Ile Ser Leu Ile Gln Asp Met Arg His Ile Gln Asn Ile Gly Glu
                 865                 870                 875

 atc aag act gat gtg gga aag gcc aga gca tgg gtg cga ctg tcc atg     3290
 Ile Lys Thr Asp Val Gly Lys Ala Arg Ala Trp Val Arg Leu Ser Met
             880                 885                 890

 gaa aaa aag tta ctt tcc aga cac ctg aag cag ctc ctc tca gac cat     3338
 Glu Lys Lys Leu Leu Ser Arg His Leu Lys Gln Leu Leu Ser Asp His
         895                 900                 905

 gag ctc acc aaa aag tta tat aag cgc tat gcc ttc ctg cgc tgt gat     3386
 Glu Leu Thr Lys Lys Leu Tyr Lys Arg Tyr Ala Phe Leu Arg Cys Asp
     910                 915                 920

 gac gag aag gag cag ttc ctc tat cac ctc ctg tct ttc aat gcc gtc     3434
 Asp Glu Lys Glu Gln Phe Leu Tyr His Leu Leu Ser Phe Asn Ala Val
 925                 930                 935                 940

 gat tac ttt tgc ttc acc aat gtc ttc aca act atc ctg atc ccg tac     3482
 Asp Tyr Phe Cys Phe Thr Asn Val Phe Thr Thr Ile Leu Ile Pro Tyr
                 945                 950                 955

 cac att ctg atc gta cca agc aag aag ctg ggg ggc tcc atg ttc act     3530
 His Ile Leu Ile Val Pro Ser Lys Lys Leu Gly Gly Ser Met Phe Thr
             960                 965                 970

 gcc aac cca tgg atc tgt ata tca gga gaa ttg ggt gag aca cag atc     3578
 Ala Asn Pro Trp Ile Cys Ile Ser Gly Glu Leu Gly Glu Thr Gln Ile
         975                 980                 985

 atg cag att ccc agg aat gtg cta gag atg acc ttc gag tgc cag aac     3626
 Met Gln Ile Pro Arg Asn Val Leu Glu Met Thr Phe Glu Cys Gln Asn
     990                 995                1000

 ttg ggg aag ctt act act gtc cag att ggc cat gat aac tct ggg ctg     3674
 Leu Gly Lys Leu Thr Thr Val Gln Ile Gly His Asp Asn Ser Gly Leu
1005                1010                1015                1020

 tat gcc aaa tgg ctg gtg gag tat gtg atg gtc agg aat gag atc aca     3722
 Tyr Ala Lys Trp Leu Val Glu Tyr Val Met Val Arg Asn Glu Ile Thr
                1025                1030                1035

 gga cat acc tac aag ttc ccg tgt ggc cgg tgg tta ggg aag ggc atg     3770
 Gly His Thr Tyr Lys Phe Pro Cys Gly Arg Trp Leu Gly Lys Gly Met
            1040                1045                1050

 gat gat gga agc ctg gag cgg atc cta gtt ggg gag ctg ctc aca tcc     3818
 Asp Asp Gly Ser Leu Glu Arg Ile Leu Val Gly Glu Leu Leu Thr Ser
        1055                1060                1065

 cag cct gag gtg gat gag agg cca tgc cgg acc ccg ccg ctg cag cag     3866
 Gln Pro Glu Val Asp Glu Arg Pro Cys Arg Thr Pro Pro Leu Gln Gln
    1070                1075                1080

 tcc ccc agt gtc atc cgg agg ctt gtt acc atc tca ccc aac aac aag     3914
 Ser Pro Ser Val Ile Arg Arg Leu Val Thr Ile Ser Pro Asn Asn Lys
1085                1090                1095                1100

 ccc aag ctg aac act ggg cag atc cag gag tcc atc ggg gag gca gtc     3962
 Pro Lys Leu Asn Thr Gly Gln Ile Gln Glu Ser Ile Gly Glu Ala Val
                1105                1110                1115

 aat ggc att gtg aag cac ttc cat aag cct gag aaa gag cga ggc agt     4010
 Asn Gly Ile Val Lys His Phe His Lys Pro Glu Lys Glu Arg Gly Ser
            1120                1125                1130

 ctg acg ctg ttg ctc tgt gga gag tgt ggc ctt gtc tcg gcc ttg gaa     4058
 Leu Thr Leu Leu Leu Cys Gly Glu Cys Gly Leu Val Ser Ala Leu Glu
        1135                1140                1145

 cag gct ttc cag cat gga ttt aaa tcg ccc cgg ctc ttc aaa aat gtc     4106
 Gln Ala Phe Gln His Gly Phe Lys Ser Pro Arg Leu Phe Lys Asn Val
    1150                1155                1160

 ttc att tgg gat ttc ctg gaa aaa gca caa acc tat tat gag aca tta     4154
 Phe Ile Trp Asp Phe Leu Glu Lys Ala Gln Thr Tyr Tyr Glu Thr Leu
1165                1170                1175                1180

 gag aag aat gaa gta gtc cct gag gaa aac tgg cat aca aga gcc cgg     4202
 Glu Lys Asn Glu Val Val Pro Glu Glu Asn Trp His Thr Arg Ala Arg
                1185                1190                1195

 aac ttc tgc cga ttt gtc act gca atc aac aat act ccc cgg aac atc     4250
 Asn Phe Cys Arg Phe Val Thr Ala Ile Asn Asn Thr Pro Arg Asn Ile
            1200                1205                1210

 ggc aag gat ggc aag ttt cag atg ctg gtg tgc ttg gga gcc agg ggt     4298
 Gly Lys Asp Gly Lys Phe Gln Met Leu Val Cys Leu Gly Ala Arg Gly
        1215                1220                1225

 atc atg aag att aaa tct ctt atg tca gtg cca gca cat gct gag tgt     4346
 Ile Met Lys Ile Lys Ser Leu Met Ser Val Pro Ala His Ala Glu Cys
    1230                1235                1240

 tat gtg aga gat cac ctc cta cac cac tgg att gcc ctg ctg gct gac     4394
 Tyr Val Arg Asp His Leu Leu His His Trp Ile Ala Leu Leu Ala Asp
1245                1250                1255                1260

 tgc ccc atc act gca cac atg tat gag gat gtg gca ctg atc aaa gac     4442
 Cys Pro Ile Thr Ala His Met Tyr Glu Asp Val Ala Leu Ile Lys Asp
                1265                1270                1275

 cat aca ctt gtc aat tcc ttg att cgt gtg ctg cag aca ttg cag gag     4490
 His Thr Leu Val Asn Ser Leu Ile Arg Val Leu Gln Thr Leu Gln Glu
            1280                1285                1290

 ttc aac atc acg ctg gag acg tcc ctt gtc aag ggc atc gac atc tga     4538
 Phe Asn Ile Thr Leu Glu Thr Ser Leu Val Lys Gly Ile Asp Ile 
        1295                1300                1305

 cctcccagca ccagccagca gcaggactga gaaagactca ccctgcagct ctgacctttt   4598

 ttcccaaagg gacttaagcg attgtgcagg agtaggagac aaaatgtaca ctcactgtaa   4658

 aaagaaaact agaggatttt tggaataaat aatctatttt agagtttatt tgctgatttg   4718

 ctttttacac actttcatgt gaaagagtga tagggagagg gagcgaggct ggtgccgctt   4778

 attttgaagc tggtgccctc cctcgccgtg gccacatgct ggaagcctga ggcctccctg   4838

 gactgagcct gtggcactgc gtgcgggaca gttatgtttc cttgccccgt cgcattaatg   4898

 aggcccttcc acatcatttt taaactaatg tttttctata ttaacattat tatggatatt   4958

 tggctttcat aggccacaca caggtgtgct gcgcgggaag ccccatgctc caatcaaagg   5018

 gatttttagt agtgcctcta agcaagcacc gatgagtcag tcccacgtat tttctttttt   5078

 gtcagtattg tttgggaagg agacatgccg ggatgtgtca tcgtgccaaa taccacattt   5138

 cctgttggca cagtttcaca gaagtaaaca taagcatgtt ttaacaggtt tttcttttct   5198

 tttttctttt ttaaaatgtt ttatttattt aacccgccat tgtgtgtttt taagtatttt   5258

 ctttttttaa ggaaaggaaa agcttgtcac aatctaactg gctatgttat tattattaaa   5318

 tttatgtttt gcaacttaga aaccagctac agtatggccc acttaataaa acacctgaaa   5378

 caaaaaaaa                                                           5387




      <210> 114
      <211> 1200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(1146)

      <400> 114
 atttccgcgt ctgtttggtc cggctgctgt cgttggttgt gagcggcatc tctcgccgtt     60

 tccccgggct gcgggagctg gcggccgggc tggggctgct gggcggaggt tcagccgtct    120

 gtatatctcc ccagatacct gaaactgacc acctgagtac gttttcccat tgctgagctg    180

 tttccctgat atctggcc  atg caa cgg aga tca aga ggg ata aat act gga     231
                      Met Gln Arg Arg Ser Arg Gly Ile Asn Thr Gly
                        1               5                  10

 ctt att cta ctc ctt tct caa atc ttc cat gtt ggg atc aac aat att      279
 Leu Ile Leu Leu Leu Ser Gln Ile Phe His Val Gly Ile Asn Asn Ile
              15                  20                  25

 cca cct gtc acc cta gca act ttg gcc ctc aac atc tgg ttc ttc ttg      327
 Pro Pro Val Thr Leu Ala Thr Leu Ala Leu Asn Ile Trp Phe Phe Leu
          30                  35                  40

 aac cct cag aag cca ctg tat agc tcc tgc ctt agt gtg gag aag tgt      375
 Asn Pro Gln Lys Pro Leu Tyr Ser Ser Cys Leu Ser Val Glu Lys Cys
      45                  50                  55

 tac cag caa aaa gac tgg cag cgt tta ctg ctc tct ccc ctt cac cat      423
 Tyr Gln Gln Lys Asp Trp Gln Arg Leu Leu Leu Ser Pro Leu His His
  60                  65                  70                  75

 gct gat gat tgg cat ttg tat ttc aat atg gca tcc atg ctc tgg aaa      471
 Ala Asp Asp Trp His Leu Tyr Phe Asn Met Ala Ser Met Leu Trp Lys
                  80                  85                  90

 gga ata aat cta gaa aga aga ctg gga agt aga tgg ttt gcc tat gtt      519
 Gly Ile Asn Leu Glu Arg Arg Leu Gly Ser Arg Trp Phe Ala Tyr Val
              95                 100                 105

 atc acc gca ttt tct gta ctt act gga gtg gta tac ctg ctc ttg caa      567
 Ile Thr Ala Phe Ser Val Leu Thr Gly Val Val Tyr Leu Leu Leu Gln
         110                 115                 120

 ttt gct gtt gcc gaa ttt atg gat gaa cct gac ttc aaa agg agc tgt      615
 Phe Ala Val Ala Glu Phe Met Asp Glu Pro Asp Phe Lys Arg Ser Cys
     125                 130                 135

 gct gta ggt ttc tca gga gtt ttg ttt gct ttg aaa gtt ctt aac aac      663
 Ala Val Gly Phe Ser Gly Val Leu Phe Ala Leu Lys Val Leu Asn Asn
 140                 145                 150                 155

 cat tat tgc cct gga ggc ttt gtc aac att ttg ggc ttt cct gta ccg      711
 His Tyr Cys Pro Gly Gly Phe Val Asn Ile Leu Gly Phe Pro Val Pro
                 160                 165                 170

 aac aga ttt gct tgt tgg gtc gaa ctt gtg gct att cat tta ttc tca      759
 Asn Arg Phe Ala Cys Trp Val Glu Leu Val Ala Ile His Leu Phe Ser
             175                 180                 185

 cca ggg act tcc ttc gct ggg cat ctg gct ggg att ctt gtt gga cta      807
 Pro Gly Thr Ser Phe Ala Gly His Leu Ala Gly Ile Leu Val Gly Leu
         190                 195                 200

 atg tac act caa ggg cct ctg aag aaa atc atg gaa gca tgt gca ggc      855
 Met Tyr Thr Gln Gly Pro Leu Lys Lys Ile Met Glu Ala Cys Ala Gly
     205                 210                 215

 ggt ttt tcc tcc agt gtt ggt tac cca gga cgg caa tac tac ttt aat      903
 Gly Phe Ser Ser Ser Val Gly Tyr Pro Gly Arg Gln Tyr Tyr Phe Asn
 220                 225                 230                 235

 agt tca ggc agc tct gga tat cag gat tat tat ccg cat ggc agg cca      951
 Ser Ser Gly Ser Ser Gly Tyr Gln Asp Tyr Tyr Pro His Gly Arg Pro
                 240                 245                 250

 gat cac tat gaa gaa gca ccc agg aac tat gac acg tac aca gca gga      999
 Asp His Tyr Glu Glu Ala Pro Arg Asn Tyr Asp Thr Tyr Thr Ala Gly
             255                 260                 265

 ctg agt gaa gaa gaa cag ctc gag aga gca tta caa gcc agc ctc tgg     1047
 Leu Ser Glu Glu Glu Gln Leu Glu Arg Ala Leu Gln Ala Ser Leu Trp
         270                 275                 280

 gac cga gga aat acc aga aat agc cca cca ccc tac ggg ttt cat ctc     1095
 Asp Arg Gly Asn Thr Arg Asn Ser Pro Pro Pro Tyr Gly Phe His Leu
     285                 290                 295

 tca cca gaa gaa atg agg aga cag cgg ctt cac aga ttc gat agc cag     1143
 Ser Pro Glu Glu Met Arg Arg Gln Arg Leu His Arg Phe Asp Ser Gln
 300                 305                 310                 315

 tga ggtg gcatcttggg aagacatggc ctattcgtgt aattattgcc catttggctc     1200
 






      <210> 115
      <211> 832
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(800)

      <400> 115
 ccgcccacgt c atg gcg ccc gag gag aac gcg ggg acc gaa ctc ttg ctg      50
              Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu Leu
                1               5                  10

 cag agt ttc gag cgc cgc ttc ctg gcg gca cgc aca ctg cgc tcc ttc       98
 Gln Ser Phe Glu Arg Arg Phe Leu Ala Ala Arg Thr Leu Arg Ser Phe
      15                  20                  25

 ccc tgg cag agc tta gaa gca aag tta aga gac tca tca gat tct gag      146
 Pro Trp Gln Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu
  30                  35                  40                  45

 ctg ctg cgg gat att ttg cac aag act gtg aag cat cct gtg tgt gtg      194
 Leu Leu Arg Asp Ile Leu His Lys Thr Val Lys His Pro Val Cys Val
                  50                  55                  60

 aag cac ccg ccg tcc gtc aaa tat gcc cgg tgc ttt ctc tca gaa ctc      242
 Lys His Pro Pro Ser Val Lys Tyr Ala Arg Cys Phe Leu Ser Glu Leu
              65                  70                  75

 atc aaa aag ccc tcg gga ggc tcg gtc aca ctc tcc gag agc acg gcc      290
 Ile Lys Lys Pro Ser Gly Gly Ser Val Thr Leu Ser Glu Ser Thr Ala
          80                  85                  90

 atc atc tcc tac ggt acc aca ggc ctg gtc aca tgg gac gcc gcc ctc      338
 Ile Ile Ser Tyr Gly Thr Thr Gly Leu Val Thr Trp Asp Ala Ala Leu
      95                 100                 105

 tac ctt gca gaa tgg gcc atc gag aac ccg gca gtc ttc act aac agg      386
 Tyr Leu Ala Glu Trp Ala Ile Glu Asn Pro Ala Val Phe Thr Asn Arg
 110                 115                 120                 125

 act gtc cta gag ctt ggc agt ggt gct ggc ctc aca ggc ctg gcc atc      434
 Thr Val Leu Glu Leu Gly Ser Gly Ala Gly Leu Thr Gly Leu Ala Ile
                 130                 135                 140

 tgc aag atg tgc cgc ccc cgg gca tac atc ttc agc gac tgt cac agc      482
 Cys Lys Met Cys Arg Pro Arg Ala Tyr Ile Phe Ser Asp Cys His Ser
             145                 150                 155

 cgg gtc ctt gag cag ctc cga ggg aat gtc ctt ctc aat ggc ctc tca      530
 Arg Val Leu Glu Gln Leu Arg Gly Asn Val Leu Leu Asn Gly Leu Ser
         160                 165                 170

 tta gag gca gac atc act gcc aac gtt aga cag ccc cag gtg aca gtg      578
 Leu Glu Ala Asp Ile Thr Ala Asn Val Arg Gln Pro Gln Val Thr Val
     175                 180                 185

 gcc cag ctg gac tgg gac gtc gcg acg gtc cat cag ctc tct gcc ttc      626
 Ala Gln Leu Asp Trp Asp Val Ala Thr Val His Gln Leu Ser Ala Phe
 190                 195                 200                 205

 cag cca gat gtt gtc att gca gca gat gtg ctg tat tgc cca gaa gcc      674
 Gln Pro Asp Val Val Ile Ala Ala Asp Val Leu Tyr Cys Pro Glu Ala
                 210                 215                 220

 atc atg tcg ctg gtc ggc gtc ctg cgg agg gtg gct gct gcc ggg agg      722
 Ile Met Ser Leu Val Gly Val Leu Arg Arg Val Ala Ala Ala Gly Arg
             225                 230                 235

 acc agc ggg ctc ctg agg tct acg tgg cct tta ccg tcc gca acc cag      770
 Thr Ser Gly Leu Leu Arg Ser Thr Trp Pro Leu Pro Ser Ala Thr Gln
         240                 245                 250

 aga cgt gcc agc tgt tca cca ccg agc tag g ccgggccggg atcagatggg      821
 Arg Arg Ala Ser Cys Ser Pro Pro Ser 
     255                 260

 aagtggaacc t                                                         832




      <210> 116
      <211> 1979
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (278)..(1954)

      <400> 116
 tcggaatctc caaagacagt gggtttcatt cagaaacgcg aagacgaacg cctagccggc     60

 gcgggcagaa ccgaggacac aatgagattt gtgggaccgg gcgcccagag gctggcgcgg    120

 gggagacccc acagctaaaa tgctcggtac ccccgggcag tcgtgggtta gttagaaccg    180

 cagagccttt cccgacccct cggaagcgca gaagtatccg aaatctaccc gtttcttggg    240

 tccagcaaaa cttttaagcc aggtgtgaaa atcacaa atg tca aat gat gga aga     295
                                          Met Ser Asn Asp Gly Arg
                                            1               5

 tcc agg aat cgg gac agg cgc tac gat gag gtc cca agc gac ctg ccc      343
 Ser Arg Asn Arg Asp Arg Arg Tyr Asp Glu Val Pro Ser Asp Leu Pro
              10                  15                  20

 tat caa gat acc acc ata aga acc cac cca act ctt cat gac agt gag      391
 Tyr Gln Asp Thr Thr Ile Arg Thr His Pro Thr Leu His Asp Ser Glu
          25                  30                  35

 cgg gca gtg agc gct gat ccc ttg cca cca ccc cct ctc cca tta cag      439
 Arg Ala Val Ser Ala Asp Pro Leu Pro Pro Pro Pro Leu Pro Leu Gln
      40                  45                  50

 cca cca ttc ggc cca gac ttc tac tca agt gac aca gaa gaa cca gct      487
 Pro Pro Phe Gly Pro Asp Phe Tyr Ser Ser Asp Thr Glu Glu Pro Ala
  55                  60                  65                  70

 ata gcg cca gat ctc aaa cca gta agg cgc ttt gtc cct gac tcc tgg      535
 Ile Ala Pro Asp Leu Lys Pro Val Arg Arg Phe Val Pro Asp Ser Trp
                  75                  80                  85

 aag aac ttt ttc aga ggg aag aaa aag gac ccc gaa tgg gat aag ccg      583
 Lys Asn Phe Phe Arg Gly Lys Lys Lys Asp Pro Glu Trp Asp Lys Pro
              90                  95                 100

 gtg tct gat atc agg tac atc tcc gat gga gtg gag tgt tca cca cca      631
 Val Ser Asp Ile Arg Tyr Ile Ser Asp Gly Val Glu Cys Ser Pro Pro
         105                 110                 115

 gcc tct cca gca aga cca aac cac cgt tcg ccc ctc aac tcc tgc aaa      679
 Ala Ser Pro Ala Arg Pro Asn His Arg Ser Pro Leu Asn Ser Cys Lys
     120                 125                 130

 gat ccc tac ggc ggg tca gaa gga acc ttt agt tcc cgg aaa gag gct      727
 Asp Pro Tyr Gly Gly Ser Glu Gly Thr Phe Ser Ser Arg Lys Glu Ala
 135                 140                 145                 150

 gac gca gtg ttt ccc cgg gat ccc tat gga tct cta gac cga cac aca      775
 Asp Ala Val Phe Pro Arg Asp Pro Tyr Gly Ser Leu Asp Arg His Thr
                 155                 160                 165

 caa aca gtt cga aca tac agt gag aag gtg gag gag tat aac ctg aga      823
 Gln Thr Val Arg Thr Tyr Ser Glu Lys Val Glu Glu Tyr Asn Leu Arg
             170                 175                 180

 tac tcc tac atg aag tcg tgg gca ggc ctg ctg aga ata ctg ggt gtg      871
 Tyr Ser Tyr Met Lys Ser Trp Ala Gly Leu Leu Arg Ile Leu Gly Val
         185                 190                 195

 gtg gag ctg ctt ttg ggg gcc ggt gtc ttt gct tgt gtc aca gct tac      919
 Val Glu Leu Leu Leu Gly Ala Gly Val Phe Ala Cys Val Thr Ala Tyr
     200                 205                 210

 att cac aag gac agt gag tgg tac aac ttg ttt gga tat tca caa ccg      967
 Ile His Lys Asp Ser Glu Trp Tyr Asn Leu Phe Gly Tyr Ser Gln Pro
 215                 220                 225                 230

 tat ggc atg gga ggc gtt ggt gga ttg ggc agt atg tat ggg ggc tat     1015
 Tyr Gly Met Gly Gly Val Gly Gly Leu Gly Ser Met Tyr Gly Gly Tyr
                 235                 240                 245

 tac tac act ggc cct aag acc cct ttt gta ctc gtg gtt gct gga tta     1063
 Tyr Tyr Thr Gly Pro Lys Thr Pro Phe Val Leu Val Val Ala Gly Leu
             250                 255                 260

 gct tgg atc acc acc att att att ctg gtt ctt ggc atg tcc atg tat     1111
 Ala Trp Ile Thr Thr Ile Ile Ile Leu Val Leu Gly Met Ser Met Tyr
         265                 270                 275

 tac cgg acc att ctt ctg gac tct aat tgg tgg ccc cta act gaa ttt     1159
 Tyr Arg Thr Ile Leu Leu Asp Ser Asn Trp Trp Pro Leu Thr Glu Phe
     280                 285                 290

 gga att aac gtt gcc ttg ttt att ttg tat atg gcc gca gcc ata gtc     1207
 Gly Ile Asn Val Ala Leu Phe Ile Leu Tyr Met Ala Ala Ala Ile Val
 295                 300                 305                 310

 tat gtg aat gat acc aac cga ggt ggc ctc tgc tac tat ccg tta ttt     1255
 Tyr Val Asn Asp Thr Asn Arg Gly Gly Leu Cys Tyr Tyr Pro Leu Phe
                 315                 320                 325

 aat aca cca gtg aat gca gtg ttc tgc cgg gta gaa gga gga cag ata     1303
 Asn Thr Pro Val Asn Ala Val Phe Cys Arg Val Glu Gly Gly Gln Ile
             330                 335                 340

 gct gca atg atc ttc ctg ttt gtc acc atg ata gtt tat ctc att agt     1351
 Ala Ala Met Ile Phe Leu Phe Val Thr Met Ile Val Tyr Leu Ile Ser
         345                 350                 355

 gct ttg gtt tgc cta aag tta tgg agg cat gag gca gct cgg aga cat     1399
 Ala Leu Val Cys Leu Lys Leu Trp Arg His Glu Ala Ala Arg Arg His
     360                 365                 370

 aga gaa tat atg gaa caa cag gag ata aat gag cca tca ttg tca tcg     1447
 Arg Glu Tyr Met Glu Gln Gln Glu Ile Asn Glu Pro Ser Leu Ser Ser
 375                 380                 385                 390

 aaa agg aaa atg tgt gaa atg gcc acc agt ggt gac aga caa aga gac     1495
 Lys Arg Lys Met Cys Glu Met Ala Thr Ser Gly Asp Arg Gln Arg Asp
                 395                 400                 405

 tca gaa gtt aat ttc aag gaa ctg aga aca gca aaa atg aaa cct gaa     1543
 Ser Glu Val Asn Phe Lys Glu Leu Arg Thr Ala Lys Met Lys Pro Glu
             410                 415                 420

 cta ctg agt gga cac atc ccc cca ggc cac att cct aaa cct atc gtg     1591
 Leu Leu Ser Gly His Ile Pro Pro Gly His Ile Pro Lys Pro Ile Val
         425                 430                 435

 atg ccc gac tat gtg gca aaa tac cct gtg att cag aca gat gat gag     1639
 Met Pro Asp Tyr Val Ala Lys Tyr Pro Val Ile Gln Thr Asp Asp Glu
     440                 445                 450

 cga gaa cgc tat aaa gct gtg ttc caa gac cag ttt tca gag tac aaa     1687
 Arg Glu Arg Tyr Lys Ala Val Phe Gln Asp Gln Phe Ser Glu Tyr Lys
 455                 460                 465                 470

 gag ctg tct gca gaa gtt cag gct gtc ctg agg aag ttt gat gag ctg     1735
 Glu Leu Ser Ala Glu Val Gln Ala Val Leu Arg Lys Phe Asp Glu Leu
                 475                 480                 485

 gat gca gtg atg agc aga ttg cca cat cat tcg gaa agc cga cag gaa     1783
 Asp Ala Val Met Ser Arg Leu Pro His His Ser Glu Ser Arg Gln Glu
             490                 495                 500

 cat gag aga att tca aga atc cat gaa gag ttt aag aaa aaa aag aat     1831
 His Glu Arg Ile Ser Arg Ile His Glu Glu Phe Lys Lys Lys Lys Asn
         505                 510                 515

 gat cct aca ttt ctg gaa aaa aaa gaa cgc tgt gat tac cta aag aat     1879
 Asp Pro Thr Phe Leu Glu Lys Lys Glu Arg Cys Asp Tyr Leu Lys Asn
     520                 525                 530

 aaa ctt tct cac ata aag caa aga att caa gaa tat gat aaa gta atg     1927
 Lys Leu Ser His Ile Lys Gln Arg Ile Gln Glu Tyr Asp Lys Val Met
 535                 540                 545                 550

 aat tgg gat gta caa ggt tat tct taa cgctt attagaaacc actttattta     1979
 Asn Trp Asp Val Gln Gly Tyr Ser 
                 555





      <210> 117
      <211> 1761
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(1288)

      <400> 117
 gagaggccca ggtgaggagc aagcgcccgc gttccggaag cccgctcccg gggcc atg      58
                                                              Met
                                                                1

 ggg gca cag gtg agg ctg ccg ccc gga gag ccc tgc cga gaa gga tat      106
 Gly Ala Gln Val Arg Leu Pro Pro Gly Glu Pro Cys Arg Glu Gly Tyr
               5                  10                  15

 gtg ctg tct ctg gtc tgt cca aac tcc tcc cag gct tgg tgt gag atc      154
 Val Leu Ser Leu Val Cys Pro Asn Ser Ser Gln Ala Trp Cys Glu Ile
          20                  25                  30

 aca aat gtg tca cag ctg ctg gct tct cct gtg ctc tac acg gac ctg      202
 Thr Asn Val Ser Gln Leu Leu Ala Ser Pro Val Leu Tyr Thr Asp Leu
      35                  40                  45

 aat tac agc ata aac aac ttg agc att tca gca aat gta gaa aac aaa      250
 Asn Tyr Ser Ile Asn Asn Leu Ser Ile Ser Ala Asn Val Glu Asn Lys
  50                  55                  60                  65

 tac agt ctt tat gtg ggc ttg gta ctg gca gta agc tca agt att ttt      298
 Tyr Ser Leu Tyr Val Gly Leu Val Leu Ala Val Ser Ser Ser Ile Phe
                  70                  75                  80

 att ggc tcc agc ttc ata ctg aaa aag aag ggc ctc ttg caa ctg gcc      346
 Ile Gly Ser Ser Phe Ile Leu Lys Lys Lys Gly Leu Leu Gln Leu Ala
              85                  90                  95

 agc aag ggc ttt act aga gct gga caa ggt gga cat tct tac ctg aag      394
 Ser Lys Gly Phe Thr Arg Ala Gly Gln Gly Gly His Ser Tyr Leu Lys
         100                 105                 110

 gaa tgg ctc tgg tgg gta gga ttg ctg tca atg gga gca gga gag gct      442
 Glu Trp Leu Trp Trp Val Gly Leu Leu Ser Met Gly Ala Gly Glu Ala
     115                 120                 125

 gca aat ttt gct gct tat gct ttt gca cct gcc acc ttg gtc acc cct      490
 Ala Asn Phe Ala Ala Tyr Ala Phe Ala Pro Ala Thr Leu Val Thr Pro
 130                 135                 140                 145

 ctg ggt gct ttg agt gtt ctc ata agt gca ata tta tct tcc tac ttt      538
 Leu Gly Ala Leu Ser Val Leu Ile Ser Ala Ile Leu Ser Ser Tyr Phe
                 150                 155                 160

 tta aac gag cac ttg aac att cat ggg aaa ata ggc tgc ata tta agt      586
 Leu Asn Glu His Leu Asn Ile His Gly Lys Ile Gly Cys Ile Leu Ser
             165                 170                 175

 ata ttg ggg tca act gtg atg gtt atc cat gcc cca caa gaa gag gaa      634
 Ile Leu Gly Ser Thr Val Met Val Ile His Ala Pro Gln Glu Glu Glu
         180                 185                 190

 gtc aca tct ttg cat gaa atg gaa atg aaa ttg aga gac cca ggg ttt      682
 Val Thr Ser Leu His Glu Met Glu Met Lys Leu Arg Asp Pro Gly Phe
     195                 200                 205

 att tcc ttt gct gtg atc ata act gtg atc tcc ttg gtg ctg att ttg      730
 Ile Ser Phe Ala Val Ile Ile Thr Val Ile Ser Leu Val Leu Ile Leu
 210                 215                 220                 225

 att gtg gct ccc aag aaa gga cag acc aat ata ttg gtt tat att tca      778
 Ile Val Ala Pro Lys Lys Gly Gln Thr Asn Ile Leu Val Tyr Ile Ser
                 230                 235                 240

 atc tgt tcc ttg att gga gcg ttt tca gtt tct tct gtg aaa ggc ctg      826
 Ile Cys Ser Leu Ile Gly Ala Phe Ser Val Ser Ser Val Lys Gly Leu
             245                 250                 255

 gga att gcc att aag gag ctg ata gaa tgg aag cca gtt tac aaa cat      874
 Gly Ile Ala Ile Lys Glu Leu Ile Glu Trp Lys Pro Val Tyr Lys His
         260                 265                 270

 ccg ctg gtc ttt gtt ttg ctg gct gta ctt gtg ctt tca gta act aca      922
 Pro Leu Val Phe Val Leu Leu Ala Val Leu Val Leu Ser Val Thr Thr
     275                 280                 285

 cag att aac tat ctc aac aag gca ctg gac acc ttt aat acc tct ctt      970
 Gln Ile Asn Tyr Leu Asn Lys Ala Leu Asp Thr Phe Asn Thr Ser Leu
 290                 295                 300                 305

 gtg aca ccc att tat tat gta ttc ttc aca tcc atg gta gtg act tgc     1018
 Val Thr Pro Ile Tyr Tyr Val Phe Phe Thr Ser Met Val Val Thr Cys
                 310                 315                 320

 tct gcc atc tta ttc caa gag tgg tat ggc atg aca gct gga gat atc     1066
 Ser Ala Ile Leu Phe Gln Glu Trp Tyr Gly Met Thr Ala Gly Asp Ile
             325                 330                 335

 att ggg acc ctg agt gga ttc ttc act att atc att ggc atc ttc ctt     1114
 Ile Gly Thr Leu Ser Gly Phe Phe Thr Ile Ile Ile Gly Ile Phe Leu
         340                 345                 350

 cta cat gct ttt aaa aat act gac att act tgg agt gag ctt aca tcc     1162
 Leu His Ala Phe Lys Asn Thr Asp Ile Thr Trp Ser Glu Leu Thr Ser
     355                 360                 365

 act gct aag aaa gaa gcc gtc tct ctg aat gtc aat gaa aac aat tat     1210
 Thr Ala Lys Lys Glu Ala Val Ser Leu Asn Val Asn Glu Asn Asn Tyr
 370                 375                 380                 385

 gtt tta cta gag aac ttg gag tgt tca gcc cca gga tac aat gat gac     1258
 Val Leu Leu Glu Asn Leu Glu Cys Ser Ala Pro Gly Tyr Asn Asp Asp
                 390                 395                 400

 gtt acc ttg ttt agt aga act gat gac tga a gtctctagaa acactgagtt     1309
 Val Thr Leu Phe Ser Arg Thr Asp Asp 
             405                 410

 ttaaccaata tgagacacac gaagaggaaa atgaatgctt gcttcttgga agaactgcta   1369

 ggaaagttag catttttgca gttctaacta atttagatgt gaggccaagt aaaaatgcca   1429

 tttttttggc cattgaattt gaaaatcaaa ttgattatcc tccagaattt ctacaaactt   1489

 tgaaatactc tctaaggatc aaagaagtca aagagctatg tgtgtctcag aataatctcc   1549

 ttcttctggt cacagtatct ttgtctctgc caggtggctc ttcatttctt tggtagctat   1609

 ttttagactt acagtcattc accaatatac agttagcagt gttctgatag acacagtatc   1669

 agtcatattc tccgttgagt cataatttca aactcaacaa gatttcagaa aggtataatc   1729

 atgtaatttc tcatattaaa actgagaaga ga                                 1761




      <210> 118
      <211> 1410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(793)

      <400> 118
 gcctttacag cagtacgaaa atggacttgg ctgtggcggc ggcaac   atg gcg gac      55
                                                      Met Ala Asp
                                                        1

 gtg ata aat gtc agt gtg aac ctg gag gcc ttt tcc cag gcc att agt      103
 Val Ile Asn Val Ser Val Asn Leu Glu Ala Phe Ser Gln Ala Ile Ser
       5                  10                  15

 gcc atc cag gcg ctg cgc tcc agc gtg agc agg ttg ttc gac tgc ctg      151
 Ala Ile Gln Ala Leu Arg Ser Ser Val Ser Arg Leu Phe Asp Cys Leu
  20                  25                  30                  35

 aag gat ggg atg cgg aac aag gag acg ctg gag ggc cgg gag aag gcc      199
 Lys Asp Gly Met Arg Asn Lys Glu Thr Leu Glu Gly Arg Glu Lys Ala
                  40                  45                  50

 ttc att gcg cac ttc cag gac aac tta cat tcg gtc aac cgg gac ctc      247
 Phe Ile Ala His Phe Gln Asp Asn Leu His Ser Val Asn Arg Asp Leu
              55                  60                  65

 aat gag ctg gaa cgt ctg agc aat cag atg gga gta tct gcc aaa cgt      295
 Asn Glu Leu Glu Arg Leu Ser Asn Gln Met Gly Val Ser Ala Lys Arg
          70                  75                  80

 aga cca aag gct cag ccc aca act ctt gtc cta cca cct caa tat gtt      343
 Arg Pro Lys Ala Gln Pro Thr Thr Leu Val Leu Pro Pro Gln Tyr Val
      85                  90                  95

 gat gat gtg atc agc cgc att gac agg atg ttt cct gaa atg tcc atc      391
 Asp Asp Val Ile Ser Arg Ile Asp Arg Met Phe Pro Glu Met Ser Ile
 100                 105                 110                 115

 cac tta tcc aga ccc aat gga aca tca gca atg ctt ctg gtg acc ttg      439
 His Leu Ser Arg Pro Asn Gly Thr Ser Ala Met Leu Leu Val Thr Leu
                 120                 125                 130

 gga aag gtg ttg aaa gtg atc gtc gtc atg cgg agc ctg ttc att gat      487
 Gly Lys Val Leu Lys Val Ile Val Val Met Arg Ser Leu Phe Ile Asp
             135                 140                 145

 cga aca ata gta aag gga tat aac gag aat gtc tac aca gaa gat ggc      535
 Arg Thr Ile Val Lys Gly Tyr Asn Glu Asn Val Tyr Thr Glu Asp Gly
         150                 155                 160

 aag ctt gat ata tgg tcc aaa tcc aac tat caa gta ttc cag aag gtg      583
 Lys Leu Asp Ile Trp Ser Lys Ser Asn Tyr Gln Val Phe Gln Lys Val
     165                 170                 175

 aca gac cat gcc acc act gcc ctg ctc cac tat cag ctg ccc cag atg      631
 Thr Asp His Ala Thr Thr Ala Leu Leu His Tyr Gln Leu Pro Gln Met
 180                 185                 190                 195

 ccg gat gtc gtg gtc cga tcc ttc atg acc tgg tta aga agt tac ata      679
 Pro Asp Val Val Val Arg Ser Phe Met Thr Trp Leu Arg Ser Tyr Ile
                 200                 205                 210

 aag ctg ttc cag gcc ccg tgc cag cgc tgc ggg aag ttt ctg cag gac      727
 Lys Leu Phe Gln Ala Pro Cys Gln Arg Cys Gly Lys Phe Leu Gln Asp
             215                 220                 225

 ggc ctt ccc ccg aca tgg agg gat ttc cga acc ctc gaa gcc ttc cat      775
 Gly Leu Pro Pro Thr Trp Arg Asp Phe Arg Thr Leu Glu Ala Phe His
         230                 235                 240

 gac acc tgc cgg cag tag ccccca cgctgggccc cagcctcaga cacacagcca      829
 Asp Thr Cys Arg Gln 
     245

 agacagctgt gacaaagacg acgcagggaa ggccccacag aagggtacaa gctggctcct    889

 cacaggccaa gatgtggtac agctcgagac atcacctcca ctcacaagca gcgccaagtg    949

 tgcaaaggcc acctcttgac agcagactca ctctgtcgcg tggtgggacc aatatcccca   1009

 ctaacagcgc atgaccggca cgacacattc agacccggtg caagaaattg acaacccggc   1069

 tcctcatgtc aatgaatagt gccacgagcg cagcactgag tcacgcaaac aaagtcccgc   1129

 cctgtcgccc tggttcacag aaataacata cagccactgc gagacaggac gcactgacat   1189

 ccggcacaac gcactacaca accctccgga cattgcaaac cccatgatca accacccggc   1249

 gccactatat atcctacaga ccaatcttga ttacatatac caacaccccg actgaataca   1309

 aaacagcgct atctcatgac aagctgcata tcaccacgat ctgcaactca ccaccatacc   1369

 gagtgagaca aaacaactaa atgctatcac tagccaccca g                       1410




      <210> 119
      <211> 3032
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(3026)

      <400> 119
 ctaaagcatg atgtgactgc aaacagaatg atgagaatgt atgccaggtg aaacacaggg     60

 atcacagtca cagaagttgc ctcaaattcc agttgtctgg aaagcgatgt aaagtggact    120

 ac   atg ccg tgg gtg gag ccc aag ccc agg ccg ggg ccg gag cag aag     167
      Met Pro Trp Val Glu Pro Lys Pro Arg Pro Gly Pro Glu Gln Lys
        1               5                  10                  15

 ccc aag ctc acc aaa ccg gac tct gcc acc ggg ccg cag tgg tac cag      215
 Pro Lys Leu Thr Lys Pro Asp Ser Ala Thr Gly Pro Gln Trp Tyr Gln
                  20                  25                  30

 gaa tct cag gaa tcg gag tcg gaa ggc aag cag cca ccc ccg gga ccc      263
 Glu Ser Gln Glu Ser Glu Ser Glu Gly Lys Gln Pro Pro Pro Gly Pro
              35                  40                  45

 ctg gca ccc ccg aaa tcc ccc gaa ccc tca gga ccc ctg gcg tcg gag      311
 Leu Ala Pro Pro Lys Ser Pro Glu Pro Ser Gly Pro Leu Ala Ser Glu
          50                  55                  60

 cag gat gca ccc ctg cca gag ggg gac gat gca ccc ccc cgg ccg tcg      359
 Gln Asp Ala Pro Leu Pro Glu Gly Asp Asp Ala Pro Pro Arg Pro Ser
      65                  70                  75

 atg ctg gac gat gca ccc cgc ctg ccg ctg gag ctg gac gat gca ccc      407
 Met Leu Asp Asp Ala Pro Arg Leu Pro Leu Glu Leu Asp Asp Ala Pro
  80                  85                  90                  95

 ctg ccg gag gag gaa acc ccc gaa ccc acg gcc atc tgc agg cac cgg      455
 Leu Pro Glu Glu Glu Thr Pro Glu Pro Thr Ala Ile Cys Arg His Arg
                 100                 105                 110

 cac cgc tgt cac acc gac tgc cta gag ggg ctg ctg tcc cgc acc ttc      503
 His Arg Cys His Thr Asp Cys Leu Glu Gly Leu Leu Ser Arg Thr Phe
             115                 120                 125

 cag tgg ctg ggg tgg cag gtg ggc gcg cac ccc tgg atc ttc ctg ctg      551
 Gln Trp Leu Gly Trp Gln Val Gly Ala His Pro Trp Ile Phe Leu Leu
         130                 135                 140

 gcg ccc ttg atg ctg aca gcc gcg ctg ggc acc ggc ttc ctg tac cta      599
 Ala Pro Leu Met Leu Thr Ala Ala Leu Gly Thr Gly Phe Leu Tyr Leu
     145                 150                 155

 ccc aag gac gaa gag gaa gac cta gag gag cat tac acc cct gtg ggg      647
 Pro Lys Asp Glu Glu Glu Asp Leu Glu Glu His Tyr Thr Pro Val Gly
 160                 165                 170                 175

 agc ccg gcc aag gcg gag cgg cgc ttc gtg cag ggc cat ttc acc acc      695
 Ser Pro Ala Lys Ala Glu Arg Arg Phe Val Gln Gly His Phe Thr Thr
                 180                 185                 190

 aac gac tcc tac cgc ttc tcc gcc tcc agg agg agc acc gaa gcc aat      743
 Asn Asp Ser Tyr Arg Phe Ser Ala Ser Arg Arg Ser Thr Glu Ala Asn
             195                 200                 205

 ttc gtc tcg ctt ctg gtg gtc tcc tac agc gac tca ctg ctg gac cca      791
 Phe Val Ser Leu Leu Val Val Ser Tyr Ser Asp Ser Leu Leu Asp Pro
         210                 215                 220

 gct acc ttt gca gaa gtc agc aaa ctg gac ggc gcg gtg cag gat ctg      839
 Ala Thr Phe Ala Glu Val Ser Lys Leu Asp Gly Ala Val Gln Asp Leu
     225                 230                 235

 cgc gtg gcg cgg gaa aag gga agc cag atc cag tac cag cag gtg tgc      887
 Arg Val Ala Arg Glu Lys Gly Ser Gln Ile Gln Tyr Gln Gln Val Cys
 240                 245                 250                 255

 gcg agg tac agg gcg ctc tgc gtg ccc ccc aac ccg atc ctg tac gcc      935
 Ala Arg Tyr Arg Ala Leu Cys Val Pro Pro Asn Pro Ile Leu Tyr Ala
                 260                 265                 270

 tgg cag gtg aac aaa acg ctc aac ctg agc agc atc tcc ttc ccc gcc      983
 Trp Gln Val Asn Lys Thr Leu Asn Leu Ser Ser Ile Ser Phe Pro Ala
             275                 280                 285

 tac aac cac ggc agg cat ccc ctc tac ctg acc ggc ttc ttc gga gga     1031
 Tyr Asn His Gly Arg His Pro Leu Tyr Leu Thr Gly Phe Phe Gly Gly
         290                 295                 300

 tac atc ttg ggg ggc agc cta gga atg ggc cag tta ctc ctg cgg gcc     1079
 Tyr Ile Leu Gly Gly Ser Leu Gly Met Gly Gln Leu Leu Leu Arg Ala
     305                 310                 315

 aaa gcc atg cgg ctg ctg tac tac ctg aag acc gag gac cct gag tac     1127
 Lys Ala Met Arg Leu Leu Tyr Tyr Leu Lys Thr Glu Asp Pro Glu Tyr
 320                 325                 330                 335

 gac gtg cag agc aag cag tgg ctc acc cat ttg ctc gat caa ttt acc     1175
 Asp Val Gln Ser Lys Gln Trp Leu Thr His Leu Leu Asp Gln Phe Thr
                 340                 345                 350

 aac att aag aac atc ttg gcc ttg aaa aaa att gag gta cct ggt ggt     1223
 Asn Ile Lys Asn Ile Leu Ala Leu Lys Lys Ile Glu Val Pro Gly Gly
             355                 360                 365

 gtg ggt tta cag gga ggc cag gag aag gta gtc cac ttt aca tcg ctt     1271
 Val Gly Leu Gln Gly Gly Gln Glu Lys Val Val His Phe Thr Ser Leu
         370                 375                 380

 tcc aga caa ctg gaa ttt gag gca act tct gtg act gtg atc cct gtg     1319
 Ser Arg Gln Leu Glu Phe Glu Ala Thr Ser Val Thr Val Ile Pro Val
     385                 390                 395

 ttt cac ctg gca tac att ctc atc att ctg ttt gca gtc aca tca tgc     1367
 Phe His Leu Ala Tyr Ile Leu Ile Ile Leu Phe Ala Val Thr Ser Cys
 400                 405                 410                 415

 ttt agg ttt gac tgc ata cga aac aaa atg tgt gtt gcg gcc ttt gga     1415
 Phe Arg Phe Asp Cys Ile Arg Asn Lys Met Cys Val Ala Ala Phe Gly
                 420                 425                 430

 gtg att tct gct ttc ttg gca gtg gtg agc ggc ttt ggc ctg ctg ttg     1463
 Val Ile Ser Ala Phe Leu Ala Val Val Ser Gly Phe Gly Leu Leu Leu
             435                 440                 445

 cac att ggg gtg cca ttt gtc atc ata gtt gcc aat tca cca ttt ctt     1511
 His Ile Gly Val Pro Phe Val Ile Ile Val Ala Asn Ser Pro Phe Leu
         450                 455                 460

 att cta ggt gtt ggg gtc gat gac atg ttt atc atg att tct gcc tgg     1559
 Ile Leu Gly Val Gly Val Asp Asp Met Phe Ile Met Ile Ser Ala Trp
     465                 470                 475

 cat aag acc aac ctt gca ggt gac ata cga gag cgg atg tcc aat gtc     1607
 His Lys Thr Asn Leu Ala Gly Asp Ile Arg Glu Arg Met Ser Asn Val
 480                 485                 490                 495

 tat tca aaa gcg gca gtg tct att aca atc acc acc atc act aac atc     1655
 Tyr Ser Lys Ala Ala Val Ser Ile Thr Ile Thr Thr Ile Thr Asn Ile
                 500                 505                 510

 ctg gcc tta tat aca ggg att atg agc tct ttt agg tcc gta caa tgt     1703
 Leu Ala Leu Tyr Thr Gly Ile Met Ser Ser Phe Arg Ser Val Gln Cys
             515                 520                 525

 ttt tgc atc tat aca gga acg acc ctg tta ttt tgc tat ttt tat aac     1751
 Phe Cys Ile Tyr Thr Gly Thr Thr Leu Leu Phe Cys Tyr Phe Tyr Asn
         530                 535                 540

 atc acg tgt ttt gga gca ttt atg gcc ttg gat ggt aaa aga gaa gta     1799
 Ile Thr Cys Phe Gly Ala Phe Met Ala Leu Asp Gly Lys Arg Glu Val
     545                 550                 555

 gtc tgc cta tgc tgg ttg aaa aag gct gac cca aaa tgg ccc tca ttt     1847
 Val Cys Leu Cys Trp Leu Lys Lys Ala Asp Pro Lys Trp Pro Ser Phe
 560                 565                 570                 575

 aaa aag ttc tgc tgt ttc cca ttt ggt tct gtc cca gat gaa cat gga     1895
 Lys Lys Phe Cys Cys Phe Pro Phe Gly Ser Val Pro Asp Glu His Gly
                 580                 585                 590

 act gat atc cat cca atg agt ttg ttt ttt aga gac tat ttt ggc ccc     1943
 Thr Asp Ile His Pro Met Ser Leu Phe Phe Arg Asp Tyr Phe Gly Pro
             595                 600                 605

 ttt ctc aca agg agt gag tcc aag tat ttt gta gtc ttt ata tat gtt     1991
 Phe Leu Thr Arg Ser Glu Ser Lys Tyr Phe Val Val Phe Ile Tyr Val
         610                 615                 620

 ttg tac atc ata agc agt ata tat ggg tgt ttc cat gtg cag gaa ggt     2039
 Leu Tyr Ile Ile Ser Ser Ile Tyr Gly Cys Phe His Val Gln Glu Gly
     625                 630                 635

 tta gac ctt cga aat ctg gca agt gac gat tcc tac atc aca cca tat     2087
 Leu Asp Leu Arg Asn Leu Ala Ser Asp Asp Ser Tyr Ile Thr Pro Tyr
 640                 645                 650                 655

 ttt aac gta gag gag aat tat ttt tca gat tat ggt ccc agg gtt atg     2135
 Phe Asn Val Glu Glu Asn Tyr Phe Ser Asp Tyr Gly Pro Arg Val Met
                 660                 665                 670

 gtt att gtt act aaa aaa gtt gac tac tgg gat aaa gat gtt agg caa     2183
 Val Ile Val Thr Lys Lys Val Asp Tyr Trp Asp Lys Asp Val Arg Gln
             675                 680                 685

 aaa ctg gaa aac tgt act aaa att ttt gaa aaa aat gtc tat gta gat     2231
 Lys Leu Glu Asn Cys Thr Lys Ile Phe Glu Lys Asn Val Tyr Val Asp
         690                 695                 700

 aaa aat ctt aca gag ttt tgg tta gat gca tat gtg caa tat tta aaa     2279
 Lys Asn Leu Thr Glu Phe Trp Leu Asp Ala Tyr Val Gln Tyr Leu Lys
     705                 710                 715

 ggt aac agc caa gat cct aat gag aag aat act ttt atg aac aat att     2327
 Gly Asn Ser Gln Asp Pro Asn Glu Lys Asn Thr Phe Met Asn Asn Ile
 720                 725                 730                 735

 cct gat ttt tta agc aat ttt cca aat ttt cag cat gat att aat att     2375
 Pro Asp Phe Leu Ser Asn Phe Pro Asn Phe Gln His Asp Ile Asn Ile
                 740                 745                 750

 tct tca tca aat gaa atc att tct tcc cgg ggc ttc att cag aca aca     2423
 Ser Ser Ser Asn Glu Ile Ile Ser Ser Arg Gly Phe Ile Gln Thr Thr
             755                 760                 765

 gat gtt tct tcc tca gcc aaa aag aaa ata ttg tta ttc caa tta cga     2471
 Asp Val Ser Ser Ser Ala Lys Lys Lys Ile Leu Leu Phe Gln Leu Arg
         770                 775                 780

 cgc ata gct gaa gac tgt caa att ccc cta atg gtg tat aac cag gca     2519
 Arg Ile Ala Glu Asp Cys Gln Ile Pro Leu Met Val Tyr Asn Gln Ala
     785                 790                 795

 ttt ata tat ttt gat cag tat gct gca ata tta gaa gac act gtt aga     2567
 Phe Ile Tyr Phe Asp Gln Tyr Ala Ala Ile Leu Glu Asp Thr Val Arg
 800                 805                 810                 815

 aat gta ttg gtt gca tca gca gct atg ttc att gtt tcc tta ttg tta     2615
 Asn Val Leu Val Ala Ser Ala Ala Met Phe Ile Val Ser Leu Leu Leu
                 820                 825                 830

 atc cct tat cca ttg tgt tcc ttg tgg gtg act ttt gct atc ggt tct     2663
 Ile Pro Tyr Pro Leu Cys Ser Leu Trp Val Thr Phe Ala Ile Gly Ser
             835                 840                 845

 gtg att gta ggg gta acg ggt ttc atg gca ttc tgg aaa gtc aat ctt     2711
 Val Ile Val Gly Val Thr Gly Phe Met Ala Phe Trp Lys Val Asn Leu
         850                 855                 860

 gat tcc ata tcc atg att aat ctt gtc att tgt ata ggg ttt tct ttc     2759
 Asp Ser Ile Ser Met Ile Asn Leu Val Ile Cys Ile Gly Phe Ser Phe
     865                 870                 875

 gat ttt tct gca cac att tcc tat gca ttt gtt tct agt tct caa ccc     2807
 Asp Phe Ser Ala His Ile Ser Tyr Ala Phe Val Ser Ser Ser Gln Pro
 880                 885                 890                 895

 tca gta aac caa aaa tca gtt gag gca ttg tat ctt cta ggc tac cca     2855
 Ser Val Asn Gln Lys Ser Val Glu Ala Leu Tyr Leu Leu Gly Tyr Pro
                 900                 905                 910

 gtg tta caa agt gca att tca aca ata ata ggg gtg tgt gtt tta gct     2903
 Val Leu Gln Ser Ala Ile Ser Thr Ile Ile Gly Val Cys Val Leu Ala
             915                 920                 925

 gca gcg aaa gca tac atc ttc aga aca ttt ttt aag att atg ttt ctt     2951
 Ala Ala Lys Ala Tyr Ile Phe Arg Thr Phe Phe Lys Ile Met Phe Leu
         930                 935                 940

 gtt atg ata ttt ggg gca gct cat ggc cta att ttt att cca gta ttc     2999
 Val Met Ile Phe Gly Ala Ala His Gly Leu Ile Phe Ile Pro Val Phe
     945                 950                 955

 tta acc ttt ttt gga agg ttt att tga atatcc                          3032
 Leu Thr Phe Phe Gly Arg Phe Ile 
 960                 965





      <210> 120
      <211> 1497
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(1497)

      <400> 120
 cccacggacc ggcaggcggc ggaccgcggc ccaggctgaa gctcagggcc ctgtctgctc     60

 tgtggactca acagtttgtg gcaagacaag ctcagaactg agaagctgtc accacagtag    120

 cttggagctc ggcggcacaa ccagcaccat ctggtcgcg   atg gtg gac acg gaa     174
                                              Met Val Asp Thr Glu
                                                1               5

 agc cca ctc tgc ccc ctc tcc cca ctc gag gcc ggc gat cta gag agc      222
 Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala Gly Asp Leu Glu Ser
                  10                  15                  20

 ccg tta tct gaa gag ttc ctg caa gaa atg gga aac atc caa gag att      270
 Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly Asn Ile Gln Glu Ile
              25                  30                  35

 tcg caa tcc atc ggc gag gat agt tct gga agc ttt ggc ttt acg gaa      318
 Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser Phe Gly Phe Thr Glu
          40                  45                  50

 tac cag tat tta gga agc tgt cct ggc tca gat ggc tcg gtc atc acg      366
 Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp Gly Ser Val Ile Thr
      55                  60                  65

 gac acg ctt tca cca gct tcg agc ccc tcc tcg gtg act tat cct gtg      414
 Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser Val Thr Tyr Pro Val
  70                  75                  80                  85

 gtc ccc ggc agc gtg gac gag tct ccc agt gga gca ttg aac atc gaa      462
 Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly Ala Leu Asn Ile Glu
                  90                  95                 100

 tgt aga atc tgc ggg gac aag gcc tca ggc tat cat tac gga gtc cac      510
 Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr His Tyr Gly Val His
             105                 110                 115

 gcg tgt gaa ggc tgc aag ggc ttc ttt cgg cga acg att cga ctc aag      558
 Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys
         120                 125                 130

 ctg gtg tat gac aag tgc gac cgc agc tgc aag atc cag aaa aaa aaa      606
 Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys Ile Gln Lys Lys Lys
     135                 140                 145

 aaa aaa aaa tgc cag tat tgt cga ttt cac aag tgc ctt tct gtc ggg      654
 Lys Lys Lys Cys Gln Tyr Cys Arg Phe His Lys Cys Leu Ser Val Gly
 150                 155                 160                 165

 atg tca cac aac gcg att cgt ttt gga cga atg cca aga tct gag aaa      702
 Met Ser His Asn Ala Ile Arg Phe Gly Arg Met Pro Arg Ser Glu Lys
                 170                 175                 180

 gca aaa ctg aaa gca gaa att ctt acc tgt gaa cat gac ata gaa gat      750
 Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu His Asp Ile Glu Asp
             185                 190                 195

 tct gaa act gca gat ctc aaa tct ctg gcc aag aga atc tac gag gcc      798
 Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys Arg Ile Tyr Glu Ala
         200                 205                 210

 tac ttg aag aac ttc aac atg aac aag gtc aaa gcc cgg gtc atc ctc      846
 Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys Ala Arg Val Ile Leu
     215                 220                 225

 tca gga aag gcc agt aac aat cca cct ttt gtc ata cat gat atg gag      894
 Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val Ile His Asp Met Glu
 230                 235                 240                 245

 aca ctg tgt atg gct gag aag acg ctg gtg gcc aag ctg gtg gcc aat      942
 Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala Lys Leu Val Ala Asn
                 250                 255                 260

 ggc atc cag aac aag gag gcg gag gtc cgc atc ttt cac tgc tgc cag      990
 Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile Phe His Cys Cys Gln
             265                 270                 275

 tgc acg tca gtg gag acc gtc acg gag ctc acg gaa ttc gcc aag gcc     1038
 Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr Glu Phe Ala Lys Ala
         280                 285                 290

 atc cca ggc ttc gca aac ttg gac ctg aac gat caa gtg aca ttg cta     1086
 Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu
     295                 300                 305

 aaa tac gga gtt tat gag gcc ata ttc gcc atg ctg tct tct gtg atg     1134
 Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met Leu Ser Ser Val Met
 310                 315                 320                 325

 aac aaa gac ggg atg ctg gta gcg tat gga aat ggg ttt ata act cgt     1182
 Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn Gly Phe Ile Thr Arg
                 330                 335                 340

 gaa ttc cta aaa agc cta agg aaa ccg ttc tgt gat atc atg gaa ccc     1230
 Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys Asp Ile Met Glu Pro
             345                 350                 355

 aag ttt gat ttt gcc atg aag ttc aat gca ctg gaa ctg gat gac agt     1278
 Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser
         360                 365                 370

 gat atc tcc ctt ttt gtg gct gct atc att tgc tgt gga ggt ggt cat     1326
 Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys Cys Gly Gly Gly His
     375                 380                 385

 cag agc aac cac ccg gac gat atc ttt ctc ttc cca aaa ctt ctt caa     1374
 Gln Ser Asn His Pro Asp Asp Ile Phe Leu Phe Pro Lys Leu Leu Gln
 390                 395                 400                 405

 aaa atg gca gac ctc cgg cag ctg gtg acg gag cat gcg cag ctg gtg     1422
 Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala Gln Leu Val
                 410                 415                 420

 cag atc atc aag aag acg gag tcg gat gct gcg ctg cac ccg cta ctg     1470
 Gln Ile Ile Lys Lys Thr Glu Ser Asp Ala Ala Leu His Pro Leu Leu
             425                 430                 435

 cag gag atc tac agg gac atg tac tga                                 1497
 Gln Glu Ile Tyr Arg Asp Met Tyr 
         440                 445





      <210> 121
      <211> 2049
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1329)

      <220>
      <221> misc_feature
      <222> (1)...(2049)
      <223> n = a,t,c or g

      <400> 121
 atgctaaata ttagtgtctc ctcctacaat ccttgttgtc acaagaatgg ctatgacaac     60

 atcaatgcct tt    atg cca ttt gcc tgg aag ttc aaa gcc ttc ctg gat     108
                  Met Pro Phe Ala Trp Lys Phe Lys Ala Phe Leu Asp
                    1               5                  10

 gaa gcc caa aaa ata aag gga ctc gtc atc gag tac ttt gag tca caa      156
 Glu Ala Gln Lys Ile Lys Gly Leu Val Ile Glu Tyr Phe Glu Ser Gln
          15                  20                  25

 atc agc caa gtg tgc atg tgg ttt ttt tcc aag tac gca caa gag tgg      204
 Ile Ser Gln Val Cys Met Trp Phe Phe Ser Lys Tyr Ala Gln Glu Trp
      30                  35                  40

 aac att tcg ttt tac gag tgt gag atg ttt gaa ata caa atc tgc caa      252
 Asn Ile Ser Phe Tyr Glu Cys Glu Met Phe Glu Ile Gln Ile Cys Gln
  45                  50                  55                  60

 gag ctt cct cca cat tgg gta cag gga agc ggc ggt ctg gtg ctg cca      300
 Glu Leu Pro Pro His Trp Val Gln Gly Ser Gly Gly Leu Val Leu Pro
                  65                  70                  75

 aag gtt agt ccc ttg tac ccg gcg aac tca gga aag ttc act cga ttt      348
 Lys Val Ser Pro Leu Tyr Pro Ala Asn Ser Gly Lys Phe Thr Arg Phe
              80                  85                  90

 cgc tac aaa cct gca gca ctc ggc ctg gag ccg cct ctg ccg ccg cgg      396
 Arg Tyr Lys Pro Ala Ala Leu Gly Leu Glu Pro Pro Leu Pro Pro Arg
          95                 100                 105

 agc ttc ccg aac ctc ttc agc cgc ccg gag ccg ctc ccg gag ccc ggc      444
 Ser Phe Pro Asn Leu Phe Ser Arg Pro Glu Pro Leu Pro Glu Pro Gly
     110                 115                 120

 cgt aga ggc tgc aat cgc agc cgg gag ccc gca gcc cgc gcc ccg agc      492
 Arg Arg Gly Cys Asn Arg Ser Arg Glu Pro Ala Ala Arg Ala Pro Ser
 125                 130                 135                 140

 ccg ccg ccg ccc ttc gag ggc gcc cca ggc cgc gcc atg gtg aag gtg      540
 Pro Pro Pro Pro Phe Glu Gly Ala Pro Gly Arg Ala Met Val Lys Val
                 145                 150                 155

 acg ttc aac tcc gct ctg gcc cag aag gag gcc aag aag gac gag ccc      588
 Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu Ala Lys Lys Asp Glu Pro
             160                 165                 170

 aag agc ggc gag gag gcg ctc atc atc ccc ccc gac gcc gtc gcg gtg      636
 Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro Pro Asp Ala Val Ala Val
         175                 180                 185

 gac tgc aag gac cca gat gat gtg gta cca gtt ggc caa aga aga gcc      684
 Asp Cys Lys Asp Pro Asp Asp Val Val Pro Val Gly Gln Arg Arg Ala
     190                 195                 200

 tgg tgt tgg tgc atg tgc ttt gga cta gca ttt atg ctt gca ggt gtt      732
 Trp Cys Trp Cys Met Cys Phe Gly Leu Ala Phe Met Leu Ala Gly Val
 205                 210                 215                 220

 att cta gga gga gca tac ttg tac aaa tat ttt gca ctt caa cca gat      780
 Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr Phe Ala Leu Gln Pro Asp
                 225                 230                 235

 gac gtg tac tac tgt gga ata aag tac atc aaa gat gat gtc atc tta      828
 Asp Val Tyr Tyr Cys Gly Ile Lys Tyr Ile Lys Asp Asp Val Ile Leu
             240                 245                 250

 aat gag ccc tct gca gat gcc cca gct gct ctc tac cag aca att gaa      876
 Asn Glu Pro Ser Ala Asp Ala Pro Ala Ala Leu Tyr Gln Thr Ile Glu
         255                 260                 265

 gaa aat att aaa atc ttt gaa gaa gaa gaa gtt gaa ttt atc agt gtg      924
 Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu Val Glu Phe Ile Ser Val
     270                 275                 280

 cct gtc cca gag ttt gca gat agt gat cct gcc aac att gtt cat gac      972
 Pro Val Pro Glu Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp
 285                 290                 295                 300

 ttt aac aag aaa ctt aca gcc tat tta gat ctt aac ctg gat aag tgc     1020
 Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys
                 305                 310                 315

 tat gtg atc cct ctg aac act tcc att gtt atg cca ccc aga aac cta     1068
 Tyr Val Ile Pro Leu Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu
             320                 325                 330

 ctg gag tta ctt att aac atc aag gct gga acc tat ttg cct cag tcc     1116
 Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser
         335                 340                 345

 tat ctg att cat gag cac atg gtt att act gat cgc att gaa aac att     1164
 Tyr Leu Ile His Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Ile
     350                 355                 360

 gat cac ctg ggt ttc ttt att tat cga ctg tgt cat gac aag gaa act     1212
 Asp His Leu Gly Phe Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr
 365                 370                 375                 380

 tac aaa ctg caa cgc aga gaa act att aaa ggt att cag aaa cgt gaa     1260
 Tyr Lys Leu Gln Arg Arg Glu Thr Ile Lys Gly Ile Gln Lys Arg Glu
                 385                 390                 395

 gcc agc aat tgt ttc gca att cgg cat ttt gaa aac aaa ttt gcc gtg     1308
 Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn Lys Phe Ala Val
             400                 405                 410

 gaa act tta att tgt tct tga ac agtcaagaaa aacattattg aggaaaatta     1361
 Glu Thr Leu Ile Cys Ser 
         415

 atatcacagc ataaccccac cctttacatt ttgtgcagtg attatttttt aaagtcttct   1421

 ttcatgtaag tagcaaacag ggctttacta tcttttcatc tcattaattc aattaaaacc   1481

 attaccttaa aatttttttc tttcgaagtg tggtgtcttt tatatttgaa ttagtaactg   1541

 tatgaagtca tagataatag tacatgtcac cttaggtagt aggaagaatt acaatttctt   1601

 taaatcattt atctggattt ttatgtttta ttagcatttt caagaagacg gattatctag   1661

 agaataatca tatatatgca tacgtaaaaa tggaccacag tgacttattt gtagttgtta   1721

 gttgccctgc tacctagttt gttagtgcat ttgagcacac attttaattt tcctctaatt   1781

 aaaatgtgca gtattttcag tgtcaaatat atttaactat ttagagaatg atttccacct   1841

 ttatgtttta atatcctagg catctgctgt aataatattt tagaaaatgt ttggaattta   1901

 agaaataact tgtgttacta atttgtataa cccatatctg tgcaatggaa tataaatatc   1961

 acaaagttgt ttaactagac tgcgtgttgt ttttcccgta taataaaacc aaagaatagt   2021

 ttggntcttc aaaaaaaaaa aaaaaaaa                                      2049




      <210> 122
      <211> 3789
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (188)..(1933)

      <400> 122
 gaccctataa ttattaacga gctatgacat caaagctcag gtccatagat cgaatccggt     60

 tagtaacgtc cggcacgtgt ggtggcattc gccagtaagc gtggtagcat ccaacagtac    120

 ccggaagcaa aagcgggtcc tgctagcccc gcggctccga actcggtggt cctggaagct    180

 ccgcagg  atg ggg gag aag atg gcg gaa gag gag agg ttc ccc aat aca     229
          Met Gly Glu Lys Met Ala Glu Glu Glu Arg Phe Pro Asn Thr
            1               5                  10

 act cat gag ggt ttc aat gtc acc ctc cac acc acc ctg gtt gtc acg      277
 Thr His Glu Gly Phe Asn Val Thr Leu His Thr Thr Leu Val Val Thr
  15                  20                  25                  30

 acg aaa ctg gtg ctc ccg acc cct ggc aag ccc atc ctc ccc gtg cag      325
 Thr Lys Leu Val Leu Pro Thr Pro Gly Lys Pro Ile Leu Pro Val Gln
                  35                  40                  45

 aca ggg gag cag gcc cag caa gag gag cag tcc agc ggc atg acc att      373
 Thr Gly Glu Gln Ala Gln Gln Glu Glu Gln Ser Ser Gly Met Thr Ile
              50                  55                  60

 ttc ttc agc ctc ctt gtc cta gct atc tgc atc ata ttg gtg cat tta      421
 Phe Phe Ser Leu Leu Val Leu Ala Ile Cys Ile Ile Leu Val His Leu
          65                  70                  75

 ctg atc cga tac aga tta cat ttc ttg cca gag agt gtt gct gtt gtt      469
 Leu Ile Arg Tyr Arg Leu His Phe Leu Pro Glu Ser Val Ala Val Val
      80                  85                  90

 tct tta ggt att ctc atg gga gca gtt ata aaa att ata gag ttt aaa      517
 Ser Leu Gly Ile Leu Met Gly Ala Val Ile Lys Ile Ile Glu Phe Lys
  95                 100                 105                 110

 aaa ctg gcg aat tgg aag gaa gaa gaa atg ttt cgt cca aac atg ttt      565
 Lys Leu Ala Asn Trp Lys Glu Glu Glu Met Phe Arg Pro Asn Met Phe
                 115                 120                 125

 ttc ctc ctc ctg ctt ccc cct att atc ttt gag tct gga tat tca tta      613
 Phe Leu Leu Leu Leu Pro Pro Ile Ile Phe Glu Ser Gly Tyr Ser Leu
             130                 135                 140

 cac aag ggt aac ttc ttt caa aat att ggt tcc atc acc ctg ttt gct      661
 His Lys Gly Asn Phe Phe Gln Asn Ile Gly Ser Ile Thr Leu Phe Ala
         145                 150                 155

 gtt ttt gga acg gca atc tcc gct ttt gta gta ggt gga gga att tat      709
 Val Phe Gly Thr Ala Ile Ser Ala Phe Val Val Gly Gly Gly Ile Tyr
     160                 165                 170

 ttt ctg ggt cag gct gat gta atc tct aaa ctc aac atg aca gac agt      757
 Phe Leu Gly Gln Ala Asp Val Ile Ser Lys Leu Asn Met Thr Asp Ser
 175                 180                 185                 190

 ttt gcg ttt ggc tcc cta ata tct gct gtc gat cca gtg gcc act att      805
 Phe Ala Phe Gly Ser Leu Ile Ser Ala Val Asp Pro Val Ala Thr Ile
                 195                 200                 205

 gcc att ttc aat gca ctt cat gtg gac ccc gtg ctc aac atg ctg gtc      853
 Ala Ile Phe Asn Ala Leu His Val Asp Pro Val Leu Asn Met Leu Val
             210                 215                 220

 ttt gga gaa agt att ctc aac gat gca gtc tcc att gtt ctg acc aac      901
 Phe Gly Glu Ser Ile Leu Asn Asp Ala Val Ser Ile Val Leu Thr Asn
         225                 230                 235

 aca gct gaa ggt tta aca aga aaa aat atg tca gat gtc agt ggg tgg      949
 Thr Ala Glu Gly Leu Thr Arg Lys Asn Met Ser Asp Val Ser Gly Trp
     240                 245                 250

 caa aca ttt tta caa gcc ctt gac tac ttc ctc aaa atg ttc ttt ggc      997
 Gln Thr Phe Leu Gln Ala Leu Asp Tyr Phe Leu Lys Met Phe Phe Gly
 255                 260                 265                 270

 tct gca gcg ctc ggc act ctc act ggc tta att tct gca tta gtg ctg     1045
 Ser Ala Ala Leu Gly Thr Leu Thr Gly Leu Ile Ser Ala Leu Val Leu
                 275                 280                 285

 aag cat att gac ttg agg aaa acg cct tcc ttg gag ttt ggc atg atg     1093
 Lys His Ile Asp Leu Arg Lys Thr Pro Ser Leu Glu Phe Gly Met Met
             290                 295                 300

 atc att ttt gct tat ctg cct tat ggg ctt gca gaa gga atc tca ctc     1141
 Ile Ile Phe Ala Tyr Leu Pro Tyr Gly Leu Ala Glu Gly Ile Ser Leu
         305                 310                 315

 tca ggc atc atg gcc atc ctg ttc tca ggc atc gtg atg tcc cac tac     1189
 Ser Gly Ile Met Ala Ile Leu Phe Ser Gly Ile Val Met Ser His Tyr
     320                 325                 330

 acg cac cat aac ctc tcc cca gtc acc cag atc ctc atg cag cag acc     1237
 Thr His His Asn Leu Ser Pro Val Thr Gln Ile Leu Met Gln Gln Thr
 335                 340                 345                 350

 ctc cgc acc gtg gcc ttc tta tgt gaa aca tgt gtg ttt gca ttt ctt     1285
 Leu Arg Thr Val Ala Phe Leu Cys Glu Thr Cys Val Phe Ala Phe Leu
                 355                 360                 365

 ggc ctg tcc att ttt agt ttt cct cac aag ttt gaa att tcc ttt gtc     1333
 Gly Leu Ser Ile Phe Ser Phe Pro His Lys Phe Glu Ile Ser Phe Val
             370                 375                 380

 atc tgg tgc ata gtg ctt gta cta ttt ggc aga gcg gta aac att ttc     1381
 Ile Trp Cys Ile Val Leu Val Leu Phe Gly Arg Ala Val Asn Ile Phe
         385                 390                 395

 cct ctt tcc tac ctc ctg aat ttc ttc cgg gat cat aaa atc aca ccg     1429
 Pro Leu Ser Tyr Leu Leu Asn Phe Phe Arg Asp His Lys Ile Thr Pro
     400                 405                 410

 aag atg atg ttc atc atg tgg ttt agt ggc ctg cgg gga gcc atc ccc     1477
 Lys Met Met Phe Ile Met Trp Phe Ser Gly Leu Arg Gly Ala Ile Pro
 415                 420                 425                 430

 tat gcc ctg agc cta cac ctg gac ctg gag ccc atg gag aag cgg cag     1525
 Tyr Ala Leu Ser Leu His Leu Asp Leu Glu Pro Met Glu Lys Arg Gln
                 435                 440                 445

 ctc atc ggc acc acc acc atc gtc atc gtg ctc ttc acc atc ctg ctg     1573
 Leu Ile Gly Thr Thr Thr Ile Val Ile Val Leu Phe Thr Ile Leu Leu
             450                 455                 460

 ctg ggc ggc agc acc atg ccc ctc att cgc ctc atg gac atc gag gac     1621
 Leu Gly Gly Ser Thr Met Pro Leu Ile Arg Leu Met Asp Ile Glu Asp
         465                 470                 475

 gcc aag gca cac cgc agg aac aag aag gac gtc aac ctc agc aag act     1669
 Ala Lys Ala His Arg Arg Asn Lys Lys Asp Val Asn Leu Ser Lys Thr
     480                 485                 490

 gag aag atg ggc aac act gtg gag tcg gag cac ctg tcg gag ctc acg     1717
 Glu Lys Met Gly Asn Thr Val Glu Ser Glu His Leu Ser Glu Leu Thr
 495                 500                 505                 510

 gag gag gag tac gag gcc cac tac atc agg cgg cag gac ctt aag ggc     1765
 Glu Glu Glu Tyr Glu Ala His Tyr Ile Arg Arg Gln Asp Leu Lys Gly
                 515                 520                 525

 ttc gtg tgg ctg gac gcc aag tac ctg aac ccc ttc ttc act cgg agg     1813
 Phe Val Trp Leu Asp Ala Lys Tyr Leu Asn Pro Phe Phe Thr Arg Arg
             530                 535                 540

 ctg acg cag gag gac ctg cac cac ggg cgc atc cag atg aaa act ctc     1861
 Leu Thr Gln Glu Asp Leu His His Gly Arg Ile Gln Met Lys Thr Leu
         545                 550                 555

 acc aac aag tgg tac gag gag gta cgc cag ggc ccc tcc ggc tcc gag     1909
 Thr Asn Lys Trp Tyr Glu Glu Val Arg Gln Gly Pro Ser Gly Ser Glu
     560                 565                 570

 gac gac gag cag gag ctg ctc tga cgccaggtgc caaggcttca ggcaggcagg    1963
 Asp Asp Glu Gln Glu Leu Leu 
 575                 580

 cccaggatgg gcgtttgctg cgcacagaca ctcagcaggg gcctcgcaga gatgcgtgca   2023

 tccagcagcc ccttcaagac ataagagggc ggggcgaggt actggctgca gagtcgcctt   2083

 agtccagaac ctgacaggcc tctggagcca ggcgacttct tgggaaactg tcatctcccg   2143

 actcctccct gagccagcct ccgctcagtg tggctcctca gcccacagag gggagggagc   2203

 atggggccag gtgccagtca tctgtgaagc tagggcgcct acccccccac ccggaggacc   2263

 cctgcggccc cctgcctaga ggagcaccat ctacagttgt gccattcccc agccactgcc   2323

 ttcatgctgc ccccgccgga ctggcagagc caggggtcag ccacctgcct ttgagtcatc   2383

 aagatgcctc tgcagccaca attctgacct aagtggcagg gcccagaaat cctgaaaacc   2443

 tcccgctgcc ttttgtgata cttcctgtgc tccctcagag agaaacggag tgaccttttg   2503

 tcctttacct gattggcact tcgcagtcta tctccctggg tagcagacgg ctgctgccct   2563

 tctctgggca tgttctgaat gtttacactg gtaccttctg gtatcttctt tagagccccc   2623

 tgcaagctgc aactctaggc ttttatcttg cggggtcaga gcgccctcta gagggaaaag   2683

 ctagaggcac agggtttctg ccggcccaca actgctgtct tgttttgcat tttacagcaa   2743

 agtgctgaga gcctctagtc gcctcctgcc atctgatctc cctccccacc attcccgtac   2803

 tcagttgttc ttttgtctaa tcggaggcca ctgtgctgag gccctgcagt gtctgctcac   2863

 tgctgccatc ttcgctgcta gtcagggttc catcctcttt cccctctccc agttccctac   2923

 cacgttggat cccattcgtc acccaggatt tgttgggggc aaagggggtg gcgggaccgt   2983

 tcccaggagg taccagcacc tgcctcgatc tcctctgagc ctcttctgcc ccatgaggcc   3043

 aagccctgcc gatggcacct ttgccaaagg ttttaagaag ggtccccagt cacccatctt   3103

 tcagcattcc atggcacaca aaggaatcct gtgggctaac ctgggcgact ctggcgctca   3163

 ggcctacccc ttggcctcat gccagccagc ccagcccagc tcacccactg tgaagagggg   3223

 tggctggctt agggtagggg ccgagagggc ttcagttctg cctctggaca gtgtgtctga   3283

 cctccagatg atggaactga gccaccctta gcctggccct ggcccatccc cctgcacact   3343

 tatctcgggg acctagaagc cagccctttt ccctgcgaga ccccacacaa gccacggggt   3403

 ggttgttccg aggggtcata acaactacag gctgcagaaa gcatgggatt cattccaaga   3463

 actcgttcca cacagcagtg cctgtggtgg aggggctgct ggctaaaggg ctggtttcct   3523

 ccagcgctcc ctggctccag ccttcactca tcctgaagta ttcctcctac acgccacagt   3583

 tctcctgtac catggcctag acccagaaga aaataaatac acacgcagga agatatagtt   3643

 aagctgcgta tttttatatc ttctatgcat tcactgcccc aaatagaatt attgggtgtg   3703

 ctaaaggtag acagcagcaa tttgttattc tcaggcaaaa aaaactgacc cagaaaaaca   3763

 gacttctatg gccttcctcg tccaac                                        3789




      <210> 123
      <211> 1714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (462)..(1394)

      <400> 123
 atgaaaacaa gtctaagaat atcaagtgta aaaatattta aatttctcat tccccagatt     60

 cagaatattg aggaaaggag gattgctcct tttggagcaa tacctcagtc agggtattct    120

 gtgccaaatc ttcctcacca aattattctg gttgctgatg ctttccttgc agaaatttct    180

 gtgcccacgg aaggtttcag aggcagatta tctggattaa ataagaaaag acctttagta    240

 atcactgatt ctaagggaag ccgactttcg cttcccgtca gcagcctttg gcggaagagt    300

 gtcccgcctc ttccgctcta cagcggaggt ggctgtggcg gtggcgctgg tggctgcggc    360

 ggcggcggcg gcagcggcgc tcgagcggtt cctgtcaggg tcagccggcg ggccccctgg    420

 gtggtccacc tgcaaatcgc ggagcggcgc cccagggatc g    atg gcg atg aac     473
                                                  Met Ala Met Asn
                                                    1

 tat aac gcg aag gat gaa gtg gac ggt ggg ccc ccg tgt gct ccg ggg      521
 Tyr Asn Ala Lys Asp Glu Val Asp Gly Gly Pro Pro Cys Ala Pro Gly
   5                  10                  15                  20

 ggc acc gcg aag act cgg aga ccg gat aac acg gcc ttc aaa cag caa      569
 Gly Thr Ala Lys Thr Arg Arg Pro Asp Asn Thr Ala Phe Lys Gln Gln
                  25                  30                  35

 cgg ctg cca gct tgg cag ccc atc ctt acg gct ggc acg gtg cta cct      617
 Arg Leu Pro Ala Trp Gln Pro Ile Leu Thr Ala Gly Thr Val Leu Pro
              40                  45                  50

 att ttc ttc atc atc ggt ctc atc ttc att ccc atc ggc att ggc att      665
 Ile Phe Phe Ile Ile Gly Leu Ile Phe Ile Pro Ile Gly Ile Gly Ile
          55                  60                  65

 ttt gtc acc tcc aac aac atc cgc gag atc gag att gat tat acc gga      713
 Phe Val Thr Ser Asn Asn Ile Arg Glu Ile Glu Ile Asp Tyr Thr Gly
      70                  75                  80

 aca gag cct tcc agt ccc tgt aat aaa tgt tta tct ccg gat gtg aca      761
 Thr Glu Pro Ser Ser Pro Cys Asn Lys Cys Leu Ser Pro Asp Val Thr
  85                  90                  95                 100

 cct tgc ttt tgt acc att aac ttc aca ctg gaa aag tca ttt gag ggc      809
 Pro Cys Phe Cys Thr Ile Asn Phe Thr Leu Glu Lys Ser Phe Glu Gly
                 105                 110                 115

 aac gtg ttt atg tat tat gga ctg tct aat ttc tat caa aac cat cgt      857
 Asn Val Phe Met Tyr Tyr Gly Leu Ser Asn Phe Tyr Gln Asn His Arg
             120                 125                 130

 cgt tac gtg aaa tct cga gat gat agt caa cta aat gga gat tct agt      905
 Arg Tyr Val Lys Ser Arg Asp Asp Ser Gln Leu Asn Gly Asp Ser Ser
         135                 140                 145

 gct ttg ctt aat ccc agt aag gaa tgt gaa cct tat cga aga aat gaa      953
 Ala Leu Leu Asn Pro Ser Lys Glu Cys Glu Pro Tyr Arg Arg Asn Glu
     150                 155                 160

 gac aaa cca att gct cct tgt gga gct att gcc aac agc atg ttt aat     1001
 Asp Lys Pro Ile Ala Pro Cys Gly Ala Ile Ala Asn Ser Met Phe Asn
 165                 170                 175                 180

 gat aca tta gaa ttg ttt ctc att ggc aat gat tct tat cct ata cct     1049
 Asp Thr Leu Glu Leu Phe Leu Ile Gly Asn Asp Ser Tyr Pro Ile Pro
                 185                 190                 195

 atc gct ttg aaa aag aaa ggt att gct tgg tgg aca gat aaa aat gtg     1097
 Ile Ala Leu Lys Lys Lys Gly Ile Ala Trp Trp Thr Asp Lys Asn Val
             200                 205                 210

 aaa ttc aga aat ccc cct gga gga gac aac ctg gaa gaa cga ttt aaa     1145
 Lys Phe Arg Asn Pro Pro Gly Gly Asp Asn Leu Glu Glu Arg Phe Lys
         215                 220                 225

 ggt aca aca aag cct gtg aac tgg ctt aaa cca gtt tac atg ctg gat     1193
 Gly Thr Thr Lys Pro Val Asn Trp Leu Lys Pro Val Tyr Met Leu Asp
     230                 235                 240

 tct gac cca gat aat aat gga ttc ata aat gag gat ttt att gtt tgg     1241
 Ser Asp Pro Asp Asn Asn Gly Phe Ile Asn Glu Asp Phe Ile Val Trp
 245                 250                 255                 260

 atg cgt act gca gca tta cct act ttt cgc aag ttg tat cgt ctt ata     1289
 Met Arg Thr Ala Ala Leu Pro Thr Phe Arg Lys Leu Tyr Arg Leu Ile
                 265                 270                 275

 gaa agg aaa agt gat tta cat cca aca tta cca gct ggc cga tac tct     1337
 Glu Arg Lys Ser Asp Leu His Pro Thr Leu Pro Ala Gly Arg Tyr Ser
             280                 285                 290

 ttg aat gtc aca tac agt atc ctt ttt tgg ctg ggt ata cag att cat     1385
 Leu Asn Val Thr Tyr Ser Ile Leu Phe Trp Leu Gly Ile Gln Ile His
         295                 300                 305

 aga gct tga caaggag tcgagtccaa ccttatatct gtatgtggca tgttaccttg     1441
 Arg Ala 
     310

 tgctttagtt tcggtctctg cacttcttta caccaagtac tgtgtggtta tctgttgaga   1501

 atgtcatttt caacatttac gtcttctaga aaatgttttg aattcggtat ataccttggt   1561

 actggggtat gacgcatatg tggggtacaa tttacttaca aataataggt gcttgttaat   1621

 caacaagcta ggtattttac aggggagatc gtaattgggg cttacatgta acggccaatg   1681

 agagtaccta acattggtgt tgagtggtac tgg                                1714




      <210> 124
      <211> 782
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (535)..(747)

      <400> 124
 cggacgcgtg ggtaacacac gtgacgtgca tgatttaata aaataacttt actctcccta     60

 cgcatgtttg agttgaatat cattgaagtt cttaatgctg actctactat tgggttgtta    120

 atagtcttct cttgacatga ctctttatgc aacataacat acatttggta ttcttcaggg    180

 tttaaaagaa aacactgagc tgtttcctcc aagttttatt aaccttttat ttaacttact    240

 gctttatttt tttctctttt aatatggtta ttgttaaaat gagagtcact tgctagactg    300

 gtctctttaa atgtaaggtc tagtatcaat atttacttca ttcaagtgga ataaatggct    360

 ttttgtagtt acttccagtt ttcctcaaga atagaaataa gtctgttcat aagcaatacc    420

 ttcagttttg ttcagttcac ttccacgtta aataaagaat aggattattc actggtaata    480

 atagagtcat taagaaatat taagcattgc agctaaaaat tgaacaaccc tgta  atg     537
                                                              Met
                                                                1

 ata cat tta aga att att caa agg tgc tac atg gca ggg tta gag aat      585
 Ile His Leu Arg Ile Ile Gln Arg Cys Tyr Met Ala Gly Leu Glu Asn
               5                  10                  15

 aaa aag aac gtg gtg ttt gaa gca aaa cag atc tgt att ggc atc ttg      633
 Lys Lys Asn Val Val Phe Glu Ala Lys Gln Ile Cys Ile Gly Ile Leu
          20                  25                  30

 gtt ctc cct ttt atc aga tgt tgt tgc ctt gtg caa atc aca ttt tct      681
 Val Leu Pro Phe Ile Arg Cys Cys Cys Leu Val Gln Ile Thr Phe Ser
      35                  40                  45

 ctg agt ctc cat ttt ctc att tat aac atg cgg aga ata ata ctt ata      729
 Leu Ser Leu His Phe Leu Ile Tyr Asn Met Arg Arg Ile Ile Leu Ile
  50                  55                  60                  65

 ttt gtg gta gta gtg tga acattaaaaa gataatgtat gtgaaaaaaa aaaaa       782
 Phe Val Val Val Val 
                  70





      <210> 125
      <211> 1448
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(912)

      <400> 125
 agatcttaac ggctaggtag cgaggcctgg gtgttgtgag ttatttctgt tggccgcatt     60

 aggttacctg acatttgatt cattcagtgg gtcctgccta ggtcctttaa aacagaatgg    120

 actgttaggg aaaggctgcc ctgggcc    atg cag gcc gag gag acc aag ggg     171
                                  Met Gln Ala Glu Glu Thr Lys Gly
                                    1               5

 att gga ata acc agt atg gca aaa tgc ttg gtc aag atc cag act cga      219
 Ile Gly Ile Thr Ser Met Ala Lys Cys Leu Val Lys Ile Gln Thr Arg
      10                  15                  20

 cga agc ctc caa ttg cac atg gtg aac cac tgc aac agt aat gtg ttt      267
 Arg Ser Leu Gln Leu His Met Val Asn His Cys Asn Ser Asn Val Phe
  25                  30                  35                  40

 gtt cgt ctg ctg aga ctc ggc tcc aag gtc aca gct cgt aac act ggt      315
 Val Arg Leu Leu Arg Leu Gly Ser Lys Val Thr Ala Arg Asn Thr Gly
                  45                  50                  55

 gtt cca ttg cct aaa gag gag aac att tct gct ccc ttg atc tcc agc      363
 Val Pro Leu Pro Lys Glu Glu Asn Ile Ser Ala Pro Leu Ile Ser Ser
              60                  65                  70

 tcc cca gtg aag gca gcc cgg gag tat gaa gat ccc cct agt gaa gag      411
 Ser Pro Val Lys Ala Ala Arg Glu Tyr Glu Asp Pro Pro Ser Glu Glu
          75                  80                  85

 gaa gat aaa ata aaa gaa gaa cct tta acc atc tct gaa cta gtg tac      459
 Glu Asp Lys Ile Lys Glu Glu Pro Leu Thr Ile Ser Glu Leu Val Tyr
      90                  95                 100

 aac cca agt gcc agc ctg ctc ccc acc cct gtg gat gac gat gag att      507
 Asn Pro Ser Ala Ser Leu Leu Pro Thr Pro Val Asp Asp Asp Glu Ile
 105                 110                 115                 120

 gac atg ctc ttt gac tgt cct tct agg ctt gag ttg gaa aga gaa gac      555
 Asp Met Leu Phe Asp Cys Pro Ser Arg Leu Glu Leu Glu Arg Glu Asp
                 125                 130                 135

 aca gat tca ttt gag gat ctg gaa gca gat gaa aac gcc ttt ttg att      603
 Thr Asp Ser Phe Glu Asp Leu Glu Ala Asp Glu Asn Ala Phe Leu Ile
             140                 145                 150

 gct gaa gaa gag gag ctg aag gag gct cgc cgt gct ttg tcg tgg agc      651
 Ala Glu Glu Glu Glu Leu Lys Glu Ala Arg Arg Ala Leu Ser Trp Ser
         155                 160                 165

 tat gac att ctg act ggc cat att cgg gtg aac cca ctg gtc aag agt      699
 Tyr Asp Ile Leu Thr Gly His Ile Arg Val Asn Pro Leu Val Lys Ser
     170                 175                 180

 ttt tcc agg ctc ctt gtg gtg ggc ctg gga ctg ctg ctc ttt gta ttt      747
 Phe Ser Arg Leu Leu Val Val Gly Leu Gly Leu Leu Leu Phe Val Phe
 185                 190                 195                 200

 ccc ctg ctc ctc ctc ctt ttg gag tca ggt att gat ctc tcc ttc tta      795
 Pro Leu Leu Leu Leu Leu Leu Glu Ser Gly Ile Asp Leu Ser Phe Leu
                 205                 210                 215

 tgc gaa atc cgc cag aca cca gag ttt gag cag ttt cac tat gaa tac      843
 Cys Glu Ile Arg Gln Thr Pro Glu Phe Glu Gln Phe His Tyr Glu Tyr
             220                 225                 230

 tac tgt ccc ctc aag gag tgg gtg gct ggg aaa gtc cac ctc atc ctc      891
 Tyr Cys Pro Leu Lys Glu Trp Val Ala Gly Lys Val His Leu Ile Leu
         235                 240                 245

 tac atg ctg ggt tgc tca tga ag ttaatctctc acgtgactaa gggctatatt      944
 Tyr Met Leu Gly Cys Ser 
     250

 caatgctagt gatttctttt tttcagcaaa tgcctggttc tgaagggtca cggggctgtc   1004

 aacaggtgtt ccttactcat aattgattat tcaaaccttt aagttagctt tccataattc   1064

 actgcactta aataagttta aatcaaatac agttatttta gttacaggtt aggaagatgg   1124

 tctttaaata accaaaaata tgtttatttt ttattatagt gtagacatac ccttcatcta   1184

 ttatatcata atacatgtta cattggactg aattagattt tcccatttct aatagttggc   1244

 accattataa gctataaggt tcagaatcag aattttagta acaactcaag agaaagttgt   1304

 tgaatataat ccttagtgaa aacagtgtcc tctaaccaat gcctatacaa ctaaatttat   1364

 gctgggtttt tggttttgtt tttttaaaaa tatttttatg tgttcaaact attttggtaa   1424

 atttttagca aaaaaaaaaa aaaa                                          1448




      <210> 126
      <211> 2369
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(1653)

      <400> 126
 tcagtgccgc agccccgacc gccgggagct cgaacccgag ccggggccgc ccgggtggcg     60

 cggtggcggc ggctgcggct gcagcagctg cgacggctgc gggggctgct ccgggtactg    120

 cgggggcggc cgggagccgg cagccggcgg cggggccgg   atg gct ctg tgc ggg     174
                                              Met Ala Leu Cys Gly
                                                1               5

 cag gcg gcg ggc gct gcg tcg ctg ccc agc gag ctg atc gtg cac atc      222
 Gln Ala Ala Gly Ala Ala Ser Leu Pro Ser Glu Leu Ile Val His Ile
                  10                  15                  20

 ttc tct ttt ctg ccg gcg ccc gac cgg ctg cgg gcc tcg gcc tcc tgc      270
 Phe Ser Phe Leu Pro Ala Pro Asp Arg Leu Arg Ala Ser Ala Ser Cys
              25                  30                  35

 tcg cac tgg cgt gag tgc ctc ttc tat ccg gcc ctg tgg ccc cag ctc      318
 Ser His Trp Arg Glu Cys Leu Phe Tyr Pro Ala Leu Trp Pro Gln Leu
          40                  45                  50

 cgc atc tgc ctc cgc gtc tcg ccc gcg gag cag cct cgg ctg gaa ttc      366
 Arg Ile Cys Leu Arg Val Ser Pro Ala Glu Gln Pro Arg Leu Glu Phe
      55                  60                  65

 ctc atg cgc aag tgc ggc tgg ttc gtg cga gag ctg cgt gtt gaa ttc      414
 Leu Met Arg Lys Cys Gly Trp Phe Val Arg Glu Leu Arg Val Glu Phe
  70                  75                  80                  85

 gcc gcc gag aac tat ctg agc ggc ggt ggc cca ggg gac gga ggt ggc      462
 Ala Ala Glu Asn Tyr Leu Ser Gly Gly Gly Pro Gly Asp Gly Gly Gly
                  90                  95                 100

 gcg gac acc ggg act gga ggg gag gaa gtc gag gcc ctg cag ctc tca      510
 Ala Asp Thr Gly Thr Gly Gly Glu Glu Val Glu Ala Leu Gln Leu Ser
             105                 110                 115

 gct cgt tgg ctg gaa gtg ctg cgc acc tac ttg gag ctg gtg ctt tgc      558
 Ala Arg Trp Leu Glu Val Leu Arg Thr Tyr Leu Glu Leu Val Leu Cys
         120                 125                 130

 gtg ctg gtc agc atc cgg aac aac agg aac ctt cag aag ttt agt ctt      606
 Val Leu Val Ser Ile Arg Asn Asn Arg Asn Leu Gln Lys Phe Ser Leu
     135                 140                 145

 ttt gga gac ata agt gtt cta caa cag caa gga agt ttg tca aat aca      654
 Phe Gly Asp Ile Ser Val Leu Gln Gln Gln Gly Ser Leu Ser Asn Thr
 150                 155                 160                 165

 tac ctc agc aag gtg gac cct gat ggc aaa aaa att aaa caa att cag      702
 Tyr Leu Ser Lys Val Asp Pro Asp Gly Lys Lys Ile Lys Gln Ile Gln
                 170                 175                 180

 caa ctg ttt gaa gaa atc ctg agt aat agt agg caa ctg aaa tgg ctg      750
 Gln Leu Phe Glu Glu Ile Leu Ser Asn Ser Arg Gln Leu Lys Trp Leu
             185                 190                 195

 tcc tgt ggg ttt atg ctg gaa ata gta acc cca aca tca ctg tca tct      798
 Ser Cys Gly Phe Met Leu Glu Ile Val Thr Pro Thr Ser Leu Ser Ser
         200                 205                 210

 ctc tct aat gct gtt gcc aac acc atg gag cac ctc agt tta ctg gac      846
 Leu Ser Asn Ala Val Ala Asn Thr Met Glu His Leu Ser Leu Leu Asp
     215                 220                 225

 aat aat att cct ggt aac agc act ctt att act gca gtt gaa ctg gag      894
 Asn Asn Ile Pro Gly Asn Ser Thr Leu Ile Thr Ala Val Glu Leu Glu
 230                 235                 240                 245

 cga ttt gtg aat ctg cac tca ctt gcc ttg gat ttt tgt gac ttt aca      942
 Arg Phe Val Asn Leu His Ser Leu Ala Leu Asp Phe Cys Asp Phe Thr
                 250                 255                 260

 gct gag atg gca aga gtc tta act gat agc aac cat gtg cct ttg caa      990
 Ala Glu Met Ala Arg Val Leu Thr Asp Ser Asn His Val Pro Leu Gln
             265                 270                 275

 cga ctg tct ctt ctg gtt cac aat gtt tct gta atg cac aag tct ctg     1038
 Arg Leu Ser Leu Leu Val His Asn Val Ser Val Met His Lys Ser Leu
         280                 285                 290

 gac aac atg cca aat gat gag cat tgg aaa gcc ctg tca cga aag agc     1086
 Asp Asn Met Pro Asn Asp Glu His Trp Lys Ala Leu Ser Arg Lys Ser
     295                 300                 305

 acc agc ttt cgg gtc tat ata atg gct ttt gat atc aag agt gaa gat     1134
 Thr Ser Phe Arg Val Tyr Ile Met Ala Phe Asp Ile Lys Ser Glu Asp
 310                 315                 320                 325

 atg tta aag att ctg aaa ccc agt ata cca cta gag agg att cat ttt     1182
 Met Leu Lys Ile Leu Lys Pro Ser Ile Pro Leu Glu Arg Ile His Phe
                 330                 335                 340

 gat agc tat atc act tgt gtt tca ggg gct att gtt gat ctt ata tcc     1230
 Asp Ser Tyr Ile Thr Cys Val Ser Gly Ala Ile Val Asp Leu Ile Ser
             345                 350                 355

 agg caa tat gac aag ttc ctc act cat ttt att tta atg aat gat gtg     1278
 Arg Gln Tyr Asp Lys Phe Leu Thr His Phe Ile Leu Met Asn Asp Val
         360                 365                 370

 att gac aca tct ggt ttt cca gat ctt agt gac aac cga aat gaa gat     1326
 Ile Asp Thr Ser Gly Phe Pro Asp Leu Ser Asp Asn Arg Asn Glu Asp
     375                 380                 385

 ccg ttg gtt tta tta gca tgg agg tgc aca aag ctc tct ctt ctg gca     1374
 Pro Leu Val Leu Leu Ala Trp Arg Cys Thr Lys Leu Ser Leu Leu Ala
 390                 395                 400                 405

 att cat ggt tac acg gtg tgg gca cac aac ctc att gcc att gct cgt     1422
 Ile His Gly Tyr Thr Val Trp Ala His Asn Leu Ile Ala Ile Ala Arg
                 410                 415                 420

 ctt cgg ggc tct gat ctg aaa gtg ctt gaa gtc acc gaa gaa agc att     1470
 Leu Arg Gly Ser Asp Leu Lys Val Leu Glu Val Thr Glu Glu Ser Ile
             425                 430                 435

 gat ttt gac caa ggt gaa ctg gcc gac cag gat gta gat cca gtg cat     1518
 Asp Phe Asp Gln Gly Glu Leu Ala Asp Gln Asp Val Asp Pro Val His
         440                 445                 450

 aac ctt att gag cag gta tcc ctg ggc ctg ggt caa cct tgg cat gca     1566
 Asn Leu Ile Glu Gln Val Ser Leu Gly Leu Gly Gln Pro Trp His Ala
     455                 460                 465

 gtc atg gac atc gaa tca ctc agt gtc ttc act gaa cca aat cgt cat     1614
 Val Met Asp Ile Glu Ser Leu Ser Val Phe Thr Glu Pro Asn Arg His
 470                 475                 480                 485

 ttt tac aga gag atg caa agc ttc agt gaa gac att tag ctttttttta      1663
 Phe Tyr Arg Glu Met Gln Ser Phe Ser Glu Asp Ile 
                 490                 495

 atgtagaatt cctgtggtta catatgcaag tagggtccta ttatgttttt ttttcagtag   1723

 tgtgaattaa tccttttgtg ctgtgtttaa tcagtattag ctttatagaa ttatatatgt   1783

 atattctact tcttgatcaa agaacgtagt cgggtattgg tttagaagtt caaagtgaca   1843

 atgtataggg ctttcacggt taatggactt gttaccaaac cttaaggata tacagccgaa   1903

 gattgtctga ggttgctggc taactttatt tttcactgag ttactctgcc tttttgacgt   1963

 ttttattctt tgtgtgtcag agttcagagc tcaggagcca aaatattttt atacatatat   2023

 agatatatat ccatagcctg gtagatttat atgcaatgca ctgcatccat gcattctgat   2083

 agcatttcat taattttgat ttcaaatgga agataaataa tatcccaaat gaattatctg   2143

 taacagaaaa gccaagactt taactttcat tacatatcta atagttgata tcaccagtta   2203

 ccattttgaa ttttgtatag tactaggtta gaacattgct taatcctttt aaaaaaaatg   2263

 catttacgta aacacgaata ctgaaattgt tggatttttt aactatatct gacataattt   2323

 tattcatcaa ttacattaca cattcattta gcccagattt caaatg                  2369




      <210> 127
      <211> 808
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (167)..(754)

      <400> 127
 cggtggcgac ggcgatggga ccccagcgag agatctgcag ctaggctggc tgcacttgct     60

 ccacgggtca ggggatcgga gggggattga agaatgcgcc attaaaagga aagatcaagg    120

 agtaaaccag aagaagaaga aaaagaggac ttcaaagctg ggaagg   atg agt tct     175
                                                      Met Ser Ser
                                                        1

 tgc agc aac gtc tgt ggg tcc agg cag gca cag gct gca gct gag ggt      223
 Cys Ser Asn Val Cys Gly Ser Arg Gln Ala Gln Ala Ala Ala Glu Gly
       5                  10                  15

 ggt tac cag cgc tat gga gtc cgg tcc tac ctg cac cag ttt tat gag      271
 Gly Tyr Gln Arg Tyr Gly Val Arg Ser Tyr Leu His Gln Phe Tyr Glu
  20                  25                  30                  35

 gac tgt aca gcc tca att tgg gag tat gag gat gat ttc cag atc caa      319
 Asp Cys Thr Ala Ser Ile Trp Glu Tyr Glu Asp Asp Phe Gln Ile Gln
                  40                  45                  50

 aga tca cct aac agg tgg agc tca gta ttc tgg aag gtt gga ctc atc      367
 Arg Ser Pro Asn Arg Trp Ser Ser Val Phe Trp Lys Val Gly Leu Ile
              55                  60                  65

 tca ggt aca gtt ttt gtg atc ctc gga ttg act gtt ctg gca gtg ggc      415
 Ser Gly Thr Val Phe Val Ile Leu Gly Leu Thr Val Leu Ala Val Gly
          70                  75                  80

 ttt ctt gtg ccc ccc aaa atc gaa gca ttt ggc gaa gcc gat ttt gtg      463
 Phe Leu Val Pro Pro Lys Ile Glu Ala Phe Gly Glu Ala Asp Phe Val
      85                  90                  95

 gtg gtc gac aca cat gct gtc cag ttt aac agt gct ctg gac atg tac      511
 Val Val Asp Thr His Ala Val Gln Phe Asn Ser Ala Leu Asp Met Tyr
 100                 105                 110                 115

 aag ctg gca gga gct gtt ctc ttc tgc att gga ggc acg tcc atg gca      559
 Lys Leu Ala Gly Ala Val Leu Phe Cys Ile Gly Gly Thr Ser Met Ala
                 120                 125                 130

 ggg tgc ctg ctg atg tcg gtg ttt gta aag agc tac tcc aaa gaa gaa      607
 Gly Cys Leu Leu Met Ser Val Phe Val Lys Ser Tyr Ser Lys Glu Glu
             135                 140                 145

 aaa ttc ctc cag cag aag ttt aaa gaa cga atc gca gac atc aaa gcc      655
 Lys Phe Leu Gln Gln Lys Phe Lys Glu Arg Ile Ala Asp Ile Lys Ala
         150                 155                 160

 cac acc cag ccg gtt aca aaa gct cca ggg cca ggg gaa aca aag att      703
 His Thr Gln Pro Val Thr Lys Ala Pro Gly Pro Gly Glu Thr Lys Ile
     165                 170                 175

 cca gtc act ttg tcc agg gtt caa aat gtc cag cct cta ctg gca acc      751
 Pro Val Thr Leu Ser Arg Val Gln Asn Val Gln Pro Leu Leu Ala Thr
 180                 185                 190                 195

 tga aacc tttcccaccc cagttcttct tgtctgattt atgcccgtgg ttaaaaagag      808
 






      <210> 128
      <211> 3513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(2264)

      <400> 128
 aaggatcctt aattaaatta atcccccctc cccccccccg ggaggaggca gctcgcctca     60

 gctgcgctgt gcacacctcg cccgggggag gacgcagacc cgggcaggcg gcaggg        116                                                                 
 atg tcg gcg aag gag agg cca aag ggc aaa gtg atc aag gac agc gtc      164
 Met Ser Ala Lys Glu Arg Pro Lys Gly Lys Val Ile Lys Asp Ser Val
   1               5                  10                  15

 acc ctc ctg ccc tgc ttt tat ttc gtc gag ttg cct ata ttg gca tca      212
 Thr Leu Leu Pro Cys Phe Tyr Phe Val Glu Leu Pro Ile Leu Ala Ser
              20                  25                  30

 tcg gtg gtt agc ctc tat ttc ctc gaa ctc aca gat gtc ttc aaa cct      260
 Ser Val Val Ser Leu Tyr Phe Leu Glu Leu Thr Asp Val Phe Lys Pro
          35                  40                  45

 gtg cac tct gga ttt agc tgc tat gac cgg agt ctt agc atg ccg tac      308
 Val His Ser Gly Phe Ser Cys Tyr Asp Arg Ser Leu Ser Met Pro Tyr
      50                  55                  60

 att gaa cca acc cag gag gca att cca ttc ctc atg ttg ctt agc ttg      356
 Ile Glu Pro Thr Gln Glu Ala Ile Pro Phe Leu Met Leu Leu Ser Leu
  65                  70                  75                  80

 gct ttt gct gga cct gca att acg att atg gta gga gaa gga att ctc      404
 Ala Phe Ala Gly Pro Ala Ile Thr Ile Met Val Gly Glu Gly Ile Leu
                  85                  90                  95

 tac tgt tgc ctc tcc aaa aga aga aat ggg gtc gga cta gag ccc aac      452
 Tyr Cys Cys Leu Ser Lys Arg Arg Asn Gly Val Gly Leu Glu Pro Asn
             100                 105                 110

 att aat gct gga ggc tgc aac ttc aat tcc ttc ctc aga cga gct gtc      500
 Ile Asn Ala Gly Gly Cys Asn Phe Asn Ser Phe Leu Arg Arg Ala Val
         115                 120                 125

 aga ttc gtt ggt gtt cat gta ttt gga tta tgc tct aca gct ctc att      548
 Arg Phe Val Gly Val His Val Phe Gly Leu Cys Ser Thr Ala Leu Ile
     130                 135                 140

 aca gat atc ata cag ctg tcc aca gga tat caa gca cct tac ttt ctg      596
 Thr Asp Ile Ile Gln Leu Ser Thr Gly Tyr Gln Ala Pro Tyr Phe Leu
 145                 150                 155                 160

 act gtg tgc aaa cca aac tat acc tct ctg aat gta tct tgc aaa gaa      644
 Thr Val Cys Lys Pro Asn Tyr Thr Ser Leu Asn Val Ser Cys Lys Glu
                 165                 170                 175

 aat tcc tac att gtg gaa gat att tgc tca gga tct gac ctc aca gtt      692
 Asn Ser Tyr Ile Val Glu Asp Ile Cys Ser Gly Ser Asp Leu Thr Val
             180                 185                 190

 atc aac agt ggc aga aag tcc ttc cct tct caa cat gca acc ctt gct      740
 Ile Asn Ser Gly Arg Lys Ser Phe Pro Ser Gln His Ala Thr Leu Ala
         195                 200                 205

 gcc ttt gca gct gtg tat gtt tcg atg tac ttc aat tcc aca tta acg      788
 Ala Phe Ala Ala Val Tyr Val Ser Met Tyr Phe Asn Ser Thr Leu Thr
     210                 215                 220

 gat tcc tct aag ctt ctg aaa cct ctc ttg gtc ttc aca ttt atc atc      836
 Asp Ser Ser Lys Leu Leu Lys Pro Leu Leu Val Phe Thr Phe Ile Ile
 225                 230                 235                 240

 tgt gga ata atc tgc ggg cta aca cgg ata act cag tat aag aac cac      884
 Cys Gly Ile Ile Cys Gly Leu Thr Arg Ile Thr Gln Tyr Lys Asn His
                 245                 250                 255

 cca gtt gat gtc tat tgt ggc ttt tta ata gga gga gga att gca ctg      932
 Pro Val Asp Val Tyr Cys Gly Phe Leu Ile Gly Gly Gly Ile Ala Leu
             260                 265                 270

 tac ttg ggc ttg tat gct gtg ggg aat ttc ctg ccc agt gat gag agt      980
 Tyr Leu Gly Leu Tyr Ala Val Gly Asn Phe Leu Pro Ser Asp Glu Ser
         275                 280                 285

 atg ttt cag cac aga gac gcc ctc agg tct ctg aca gac ctc aat caa     1028
 Met Phe Gln His Arg Asp Ala Leu Arg Ser Leu Thr Asp Leu Asn Gln
     290                 295                 300

 gat ccc aac cga ctt tta tct gct aaa aat ggt agc agc agt gat gga     1076
 Asp Pro Asn Arg Leu Leu Ser Ala Lys Asn Gly Ser Ser Ser Asp Gly
 305                 310                 315                 320

 att gct cat aca gaa ggc atc ctc aac cga aac cac aga gat gct agc     1124
 Ile Ala His Thr Glu Gly Ile Leu Asn Arg Asn His Arg Asp Ala Ser
                 325                 330                 335

 tct ctg aca aat ctc aaa aga gca aat gct gat gtg gaa atc att act     1172
 Ser Leu Thr Asn Leu Lys Arg Ala Asn Ala Asp Val Glu Ile Ile Thr
             340                 345                 350

 cca cgg agc ccc atg ggg aag gag aac atg gtt acc ttc agc aat acc     1220
 Pro Arg Ser Pro Met Gly Lys Glu Asn Met Val Thr Phe Ser Asn Thr
         355                 360                 365

 ttg ccg cga gcc aat acc cca tct gta gaa gac cct gtc aga aga aat     1268
 Leu Pro Arg Ala Asn Thr Pro Ser Val Glu Asp Pro Val Arg Arg Asn
     370                 375                 380

 gcg agc att cat gcc tct atg gat tcc gct cga tca aag cag ctc ctc     1316
 Ala Ser Ile His Ala Ser Met Asp Ser Ala Arg Ser Lys Gln Leu Leu
 385                 390                 395                 400

 acc cag tgg aag aat aag aat gaa agt cga aag ttg tcc ttg caa gtt     1364
 Thr Gln Trp Lys Asn Lys Asn Glu Ser Arg Lys Leu Ser Leu Gln Val
                 405                 410                 415

 ata gag cct gag cct ggg cag tca cca ccc aga tcc ata gaa atg agg     1412
 Ile Glu Pro Glu Pro Gly Gln Ser Pro Pro Arg Ser Ile Glu Met Arg
             420                 425                 430

 tca agc tca gag cca tcg agg gta ggg gtg aat gga gac cac cat ggt     1460
 Ser Ser Ser Glu Pro Ser Arg Val Gly Val Asn Gly Asp His His Gly
         435                 440                 445

 cct ggc aat cag tac ctc aaa atc cag cct ggc gct gtc ccc gga tgt     1508
 Pro Gly Asn Gln Tyr Leu Lys Ile Gln Pro Gly Ala Val Pro Gly Cys
     450                 455                 460

 aac aac agc atg cct gga ggg cca aga gtg tcc att cag tcc cgt cct     1556
 Asn Asn Ser Met Pro Gly Gly Pro Arg Val Ser Ile Gln Ser Arg Pro
 465                 470                 475                 480

 ggg tcc tca cag ttg gtg cac atc cct gag gag act cag gaa aac ata     1604
 Gly Ser Ser Gln Leu Val His Ile Pro Glu Glu Thr Gln Glu Asn Ile
                 485                 490                 495

 agc acc tcc ccc aaa agc agc tct gct cgg gcc aag tgg tta aaa gct     1652
 Ser Thr Ser Pro Lys Ser Ser Ser Ala Arg Ala Lys Trp Leu Lys Ala
             500                 505                 510

 gct gaa aag act gtg gcc tgt aac aga agc aac agc cag ccc cga atc     1700
 Ala Glu Lys Thr Val Ala Cys Asn Arg Ser Asn Ser Gln Pro Arg Ile
         515                 520                 525

 atg caa gtc ata gcc atg tcc aag cag cag ggt gtc ctc caa agc agc     1748
 Met Gln Val Ile Ala Met Ser Lys Gln Gln Gly Val Leu Gln Ser Ser
     530                 535                 540

 ccc aag aac act gaa ggc agc acg gtc tcc tgc act ggc tcc atc cgc     1796
 Pro Lys Asn Thr Glu Gly Ser Thr Val Ser Cys Thr Gly Ser Ile Arg
 545                 550                 555                 560

 tat aaa acc ttg aca gac cat gag ccc agt ggg ata gtg agg gtt gag     1844
 Tyr Lys Thr Leu Thr Asp His Glu Pro Ser Gly Ile Val Arg Val Glu
                 565                 570                 575

 gct cac cca gag aac aac agg ccc atc ata cag atc ccg tcc act gaa     1892
 Ala His Pro Glu Asn Asn Arg Pro Ile Ile Gln Ile Pro Ser Thr Glu
             580                 585                 590

 ggt gaa ggc agt ggc tcc tgg aag tgg aaa gcc cct gaa aag ggc agc     1940
 Gly Glu Gly Ser Gly Ser Trp Lys Trp Lys Ala Pro Glu Lys Gly Ser
         595                 600                 605

 ctt cgc caa act tac gag ctc aac gat ctc aac agg gac tca gaa agc     1988
 Leu Arg Gln Thr Tyr Glu Leu Asn Asp Leu Asn Arg Asp Ser Glu Ser
     610                 615                 620

 tgt gag tct ctg aaa gac agc ttt ggt tct gga gat cgc aag aga agc     2036
 Cys Glu Ser Leu Lys Asp Ser Phe Gly Ser Gly Asp Arg Lys Arg Ser
 625                 630                 635                 640

 aac att gat agc aat gag cat cac cac cac gga att acc acc atc cgc     2084
 Asn Ile Asp Ser Asn Glu His His His His Gly Ile Thr Thr Ile Arg
                 645                 650                 655

 gtc acc cca gta gag ggc agc gaa att ggc tca gag acg ctg tcc att     2132
 Val Thr Pro Val Glu Gly Ser Glu Ile Gly Ser Glu Thr Leu Ser Ile
             660                 665                 670

 tct tct tcc cgc gac tcc acc ctg cgg aga aag ggc aat atc att cta     2180
 Ser Ser Ser Arg Asp Ser Thr Leu Arg Arg Lys Gly Asn Ile Ile Leu
         675                 680                 685

 atc cct gaa aga agc aac agc ccc gaa aac act aga aat atc ttc tac     2228
 Ile Pro Glu Arg Ser Asn Ser Pro Glu Asn Thr Arg Asn Ile Phe Tyr
     690                 695                 700

 aaa gga acc tcc ccc aca cgg gct tat aag gat tga gtga tgtccattcc     2278
 Lys Gly Thr Ser Pro Thr Arg Ala Tyr Lys Asp 
 705                 710                 715

 atcattaggg ctactcgcaa aagaccatat gttgattcta cctgtgttct gttccagcga   2338

 attgggaagt ctcaccaagc tagattgtct accatcagcc cagaactctg taacttttca   2398

 gaactgctat actcaaactt gcagatctca catcaaggag agggaaaagc acaatgcaag   2458

 aacctaacta acgtgatgat atgaagagtt ttcttaagac ctgtcgtcaa acttaaaagg   2518

 ttttgcagag ggcagtatca aaagaaagtg gttttcttca aatgtatact attttacttc   2578

 ctgaatgtgc caactttggg gatttttctt tatagtgagc tgtgggaacc cagaacacac   2638

 acgttttccc tacagcagag gccatgcagt attatatatt cattttgcag aatctgcacc   2698

 tacagctcaa tacgggtggt gctgattatt atagtacata taccatgtaa actctcaaac   2758

 tctatttagc tgtgaaatag tggtgtgcaa ttccttgtta aagaaatgct actttattaa   2818

 gaagatgctg gctgctttgt gttagaatag gacaccccgc agcttctctg tagtggctct   2878

 gtcacagtca aaaaatgaaa aggtttttgt gcgtttcttc aaaattctgc tttcttcaac   2938

 atcaaaaatt gtgtagaaat attttcagtg aaagggaata actagtactt ttctgcatag   2998

 tttttcttct gcttactttt tatttaagta taggtactgc taatgaatct gttttcttag   3058

 tgagtaaatt tgcataattt tataaatatt attttagaga atcttttgaa attgttgtga   3118

 tcatattttg ctttctatgg cttctcctta acttattgat taattttttg aagttataga   3178

 tatgttctcc tattttaaaa gcaaaaataa caattgacat tccttgagca aaatatactg   3238

 ctgtgaattt gcaaacaaga aatctgagcc aaaacttgac attgtgggtt acattgccag   3298

 aaatgttggt caagtttgcc cttagatgtc tacaactagc tggcataggt tgccatctta   3358

 acaagtaatc taaaagtccc attcggttct acattattaa cttttttttt ctatatcctg   3418

 atgaccagta aattagagcc acactggtta agtttgactc gtctctaaaa cgtttttgtt   3478

 aattggacac caagaggaag aatctgaaaa aaaaa                              3513




      <210> 129
      <211> 1576
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (58)..(1053)

      <400> 129
 atgaggaagg acagtgaagg ttgtgagtcc aattgcaatc gtatcggcgt ggactgc        57                                                                 
 atg ttt aaa ggc tta agg gaa tct gtc ttt gcc ttt tgc tcc cgg gtt      105
 Met Phe Lys Gly Leu Arg Glu Ser Val Phe Ala Phe Cys Ser Arg Val
   1               5                  10                  15

 atg aga aaa tgt atg tgg ctg tgc gtc cag gac agc aat gtg ttt gtc      153
 Met Arg Lys Cys Met Trp Leu Cys Val Gln Asp Ser Asn Val Phe Val
              20                  25                  30

 tct cag cca agc tca gtc ctc acc cag gca ccg ggg tca cgg tca cgt      201
 Ser Gln Pro Ser Ser Val Leu Thr Gln Ala Pro Gly Ser Arg Ser Arg
          35                  40                  45

 tca cgt tcc gtg gac gcc ttg cac gcc tcc aag agg cgg gca tgg gga      249
 Ser Arg Ser Val Asp Ala Leu His Ala Ser Lys Arg Arg Ala Trp Gly
      50                  55                  60

 atc gtc gcc ggc tta cct ggc cgt ggg cgc gtc ctg gcc gct gca gcc      297
 Ile Val Ala Gly Leu Pro Gly Arg Gly Arg Val Leu Ala Ala Ala Ala
  65                  70                  75                  80

 cgg agc agg gtg cca gcc gcc gcc gcc gcc gcc atg gtg tcc ccg gtc      345
 Arg Ser Arg Val Pro Ala Ala Ala Ala Ala Ala Met Val Ser Pro Val
                  85                  90                  95

 act gtg gtg aag agt gaa gga ccc aaa ctg gtg ccg ttc ttc aag gcc      393
 Thr Val Val Lys Ser Glu Gly Pro Lys Leu Val Pro Phe Phe Lys Ala
             100                 105                 110

 acc tgc gtg tat ttt gtg ctc tgg ctg ccc tca tct agc cca tcg tgg      441
 Thr Cys Val Tyr Phe Val Leu Trp Leu Pro Ser Ser Ser Pro Ser Trp
         115                 120                 125

 gtc agc acc ctc atc aag tgc ctg cct atc ttc tgc ctc tgg ctc ttc      489
 Val Ser Thr Leu Ile Lys Cys Leu Pro Ile Phe Cys Leu Trp Leu Phe
     130                 135                 140

 ctt ctg gcc cat ggc ctg gga ttc ctg ctg gcc cac ccc agc gcc acc      537
 Leu Leu Ala His Gly Leu Gly Phe Leu Leu Ala His Pro Ser Ala Thr
 145                 150                 155                 160

 cgc atc ttt gtg ggg ctt gtc ttc tct gct gta ggt gac gcc ttc ctc      585
 Arg Ile Phe Val Gly Leu Val Phe Ser Ala Val Gly Asp Ala Phe Leu
                 165                 170                 175

 atc tgg cag gac caa gga tac ttc gtg cat ggt ctg ctg atg ttt gct      633
 Ile Trp Gln Asp Gln Gly Tyr Phe Val His Gly Leu Leu Met Phe Ala
             180                 185                 190

 gtg acc cac atg ttc tac gcc tcg gcc ttt ggc atg cag cca ctg gct      681
 Val Thr His Met Phe Tyr Ala Ser Ala Phe Gly Met Gln Pro Leu Ala
         195                 200                 205

 ctt cgg aca ggt ctg gtg atg gca gcg ctg tcg ggc ctg tgc tat gcc      729
 Leu Arg Thr Gly Leu Val Met Ala Ala Leu Ser Gly Leu Cys Tyr Ala
     210                 215                 220

 ctc ctc tac cca tgc ctc tca ggt gcc ttc acc tac ctg gtg ggg gtc      777
 Leu Leu Tyr Pro Cys Leu Ser Gly Ala Phe Thr Tyr Leu Val Gly Val
 225                 230                 235                 240

 tat gtg gcc ctt atc ggc ttc atg ggc tgg cga gct atg gca ggg ctg      825
 Tyr Val Ala Leu Ile Gly Phe Met Gly Trp Arg Ala Met Ala Gly Leu
                 245                 250                 255

 cgg ctg gcc ggg gca gac tgg cgc tgg aca gag ctg gca gct ggc agt      873
 Arg Leu Ala Gly Ala Asp Trp Arg Trp Thr Glu Leu Ala Ala Gly Ser
             260                 265                 270

 ggt gca ctc ttc ttt atc atc tca gac ctg acc atc gcc ctc aac aaa      921
 Gly Ala Leu Phe Phe Ile Ile Ser Asp Leu Thr Ile Ala Leu Asn Lys
         275                 280                 285

 ttc tgt ttt cct gtg ccc tac tct cgg gcg ctt atc atg tcc acc tac      969
 Phe Cys Phe Pro Val Pro Tyr Ser Arg Ala Leu Ile Met Ser Thr Tyr
     290                 295                 300

 tat gtg gcc cag atg ctc gtc gcc ttg tca gct gtc gaa agc cgg gag     1017
 Tyr Val Ala Gln Met Leu Val Ala Leu Ser Ala Val Glu Ser Arg Glu
 305                 310                 315                 320

 cct gtg gaa cac tac aga ctg acc aag gcc aac tga ggtg ccagggtctg     1067
 Pro Val Glu His Tyr Arg Leu Thr Lys Ala Asn 
                 325                 330

 gtcacccctc tctcctcctg gggctggggc ccagatcctg gggacctgca ggagctggat   1127

 caggatggct gcagtgccag cctggggcag caggtactgc ctgaggaatt tgcaagttcg   1187

 tgtggggagg ctggaaaagg atctccctag cagaactcgt ggttcaggac aatgctgaga   1247

 gctaaaagag ccagcctaat atcagactgg agccagaagt agacatctcc ccacctctac   1307

 cctatcagga ctttcaaaac ccccctggaa ggtgatggtg ctcagcttct tgacaccccc   1367

 ccacccactt cccctaccag gtggaagagt ctgactccat gtgttatgcc taggaccaat   1427

 ggcagtgctg ggttcaccca ctcctcccct ttttcatctg cacaaagttg agggaaacgg   1487

 gagaatctgt gctgagaaga ctcagaccca ggagcccctt tcacaggccc ctagttggga   1547

 agactggatg agagtggaaa aaaaaaaaa                                     1576




      <210> 130
      <211> 2643
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (180)..(2531)

      <400> 130
 tgtcgttgtt ctgaggcgtg gagcacctgc tggcgcccca gcacagcctg gccaagatcg     60

 agcgcaacct tgttaacagc ctcttcccgg ccaaccgctc caagcaccgt ctctactcgg    120

 acctgcagac ccccgggcgc tacggccggg tcatcgtcac ctccttccag aaagccaac     179                                                                 
 atg ctg gac cag cat cac acc gac ctg atc tta aag ttg cat gct gct      227
 Met Leu Asp Gln His His Thr Asp Leu Ile Leu Lys Leu His Ala Ala
   1               5                  10                  15

 gtc acc aag atc cag gtt cca agg cct ggt ttt aat tac acg ttt gcc      275
 Val Thr Lys Ile Gln Val Pro Arg Pro Gly Phe Asn Tyr Thr Phe Ala
              20                  25                  30

 cat ata tgt atc ctg aat aat gat aag act tgc atc gcg gat gac ata      323
 His Ile Cys Ile Leu Asn Asn Asp Lys Thr Cys Ile Ala Asp Asp Ile
          35                  40                  45

 gtg cac gtc ctg gaa gag cta aag aat gct cgg gcc acc aat cgg acc      371
 Val His Val Leu Glu Glu Leu Lys Asn Ala Arg Ala Thr Asn Arg Thr
      50                  55                  60

 aat ttt gct atc aca tac cca atc act cac tta aag gac ggg agg gct      419
 Asn Phe Ala Ile Thr Tyr Pro Ile Thr His Leu Lys Asp Gly Arg Ala
  65                  70                  75                  80

 gtg tac aat ggg cac cag ctt ggg ggc gtc act gtg cac agc aaa gac      467
 Val Tyr Asn Gly His Gln Leu Gly Gly Val Thr Val His Ser Lys Asp
                  85                  90                  95

 cgg gtg aaa tct gca gag gcc atc cag ctc acc tac tac ctg cag tca      515
 Arg Val Lys Ser Ala Glu Ala Ile Gln Leu Thr Tyr Tyr Leu Gln Ser
             100                 105                 110

 atc aac agt ctc aat gac atg gtg gct gag agg tgg gag tcc agc ttc      563
 Ile Asn Ser Leu Asn Asp Met Val Ala Glu Arg Trp Glu Ser Ser Phe
         115                 120                 125

 tgc gac act gtc aga ctg ttt cag aaa tcc aac agc aaa gtc aaa atg      611
 Cys Asp Thr Val Arg Leu Phe Gln Lys Ser Asn Ser Lys Val Lys Met
     130                 135                 140

 tac cct tac acg tcc tcc tca ctg agg gaa gat ttc cag aag acc agc      659
 Tyr Pro Tyr Thr Ser Ser Ser Leu Arg Glu Asp Phe Gln Lys Thr Ser
 145                 150                 155                 160

 cgc gta tca gaa cgt tac ctg gtc acc agc ctg att ctg gtg gtt acc      707
 Arg Val Ser Glu Arg Tyr Leu Val Thr Ser Leu Ile Leu Val Val Thr
                 165                 170                 175

 atg gcc atc ctg tgt tgc tct atg cag gac tgc gtc cgc agc aaa ccc      755
 Met Ala Ile Leu Cys Cys Ser Met Gln Asp Cys Val Arg Ser Lys Pro
             180                 185                 190

 tgg cta ggc ctg ctc gga ttg gtg acc ata agc ctg gcc act ctc act      803
 Trp Leu Gly Leu Leu Gly Leu Val Thr Ile Ser Leu Ala Thr Leu Thr
         195                 200                 205

 gca gcc ggg atc atc aat ctt act ggt ggg aaa tat aat tcc acc ttc      851
 Ala Ala Gly Ile Ile Asn Leu Thr Gly Gly Lys Tyr Asn Ser Thr Phe
     210                 215                 220

 ctg gga gtc cct ttc gtc atg cta ggt cat gga tta tat ggg act ttt      899
 Leu Gly Val Pro Phe Val Met Leu Gly His Gly Leu Tyr Gly Thr Phe
 225                 230                 235                 240

 gaa atg tta tcc tcc tgg agg aaa act aga gaa gac caa cat gtt aaa      947
 Glu Met Leu Ser Ser Trp Arg Lys Thr Arg Glu Asp Gln His Val Lys
                 245                 250                 255

 gag aga act gca gca gtc tat gca gac tcc atg ctc tcc ttt tct ctc      995
 Glu Arg Thr Ala Ala Val Tyr Ala Asp Ser Met Leu Ser Phe Ser Leu
             260                 265                 270

 acc act gcc atg tac ctg gtc acc ttt ggc ata ggg gcc agc cct ttc     1043
 Thr Thr Ala Met Tyr Leu Val Thr Phe Gly Ile Gly Ala Ser Pro Phe
         275                 280                 285

 acg aac att gag gca gcc agg att ttc tgc tgc aat tcc tgt att gca     1091
 Thr Asn Ile Glu Ala Ala Arg Ile Phe Cys Cys Asn Ser Cys Ile Ala
     290                 295                 300

 atc ttc ttc aac tac ctc tat gta ctc tcg ttt tat ggt tcc agc cta     1139
 Ile Phe Phe Asn Tyr Leu Tyr Val Leu Ser Phe Tyr Gly Ser Ser Leu
 305                 310                 315                 320

 gtg ttc act ggc tac ata gaa aac aat tac cag cat agt atc ttc tgt     1187
 Val Phe Thr Gly Tyr Ile Glu Asn Asn Tyr Gln His Ser Ile Phe Cys
                 325                 330                 335

 aga aaa gtc cca aag cct gag gca ttg cag gag aag ccg gca tgg tac     1235
 Arg Lys Val Pro Lys Pro Glu Ala Leu Gln Glu Lys Pro Ala Trp Tyr
             340                 345                 350

 agg ttt ctc ctg acg gcc aga ttc agt gag gac aca gct gaa ggc gag     1283
 Arg Phe Leu Leu Thr Ala Arg Phe Ser Glu Asp Thr Ala Glu Gly Glu
         355                 360                 365

 gaa gcg aac act tac gag agt cac cta ttg gta tgt ttc ctc aaa cgc     1331
 Glu Ala Asn Thr Tyr Glu Ser His Leu Leu Val Cys Phe Leu Lys Arg
     370                 375                 380

 tat tac tgt gac tgg ata acc aac acc tat gtc aag cct ttt gta gtt     1379
 Tyr Tyr Cys Asp Trp Ile Thr Asn Thr Tyr Val Lys Pro Phe Val Val
 385                 390                 395                 400

 ctc ttt tac ctt att tat att tcc ttt gcc tta atg ggc tat ctg cag     1427
 Leu Phe Tyr Leu Ile Tyr Ile Ser Phe Ala Leu Met Gly Tyr Leu Gln
                 405                 410                 415

 gtc agt gaa ggg tca gac ctt agt aac att gta gca acc gcg aca caa     1475
 Val Ser Glu Gly Ser Asp Leu Ser Asn Ile Val Ala Thr Ala Thr Gln
             420                 425                 430

 acc att gag tac act act gcc cag caa aag tac ttc agc aac tac agt     1523
 Thr Ile Glu Tyr Thr Thr Ala Gln Gln Lys Tyr Phe Ser Asn Tyr Ser
         435                 440                 445

 cct gtg att ggg ttt tac ata tat gag tct ata gaa tac tgg aac act     1571
 Pro Val Ile Gly Phe Tyr Ile Tyr Glu Ser Ile Glu Tyr Trp Asn Thr
     450                 455                 460

 agt gtc caa gaa gat gtt cta gaa tac acc aag ggg ttt gtg cgg ata     1619
 Ser Val Gln Glu Asp Val Leu Glu Tyr Thr Lys Gly Phe Val Arg Ile
 465                 470                 475                 480

 tcc tgg ttt gag agc tat tta aat tac ctt cgg aaa ctc aat gta tcc     1667
 Ser Trp Phe Glu Ser Tyr Leu Asn Tyr Leu Arg Lys Leu Asn Val Ser
                 485                 490                 495

 act ggc ttg cct aag aaa aat ttc aca gac atg ttg agg aat tcc ttt     1715
 Thr Gly Leu Pro Lys Lys Asn Phe Thr Asp Met Leu Arg Asn Ser Phe
             500                 505                 510

 ctg aaa gcc cct caa ttt tca cat ttt caa gag gac atc atc ttc tct     1763
 Leu Lys Ala Pro Gln Phe Ser His Phe Gln Glu Asp Ile Ile Phe Ser
         515                 520                 525

 aaa aaa tac aat gat gag gtc gat gta gtg gcc tcc aga atg ttt ttg     1811
 Lys Lys Tyr Asn Asp Glu Val Asp Val Val Ala Ser Arg Met Phe Leu
     530                 535                 540

 gtg gcc aag acc atg gaa aca aac aga gaa gaa ctc tat gat ctc ttg     1859
 Val Ala Lys Thr Met Glu Thr Asn Arg Glu Glu Leu Tyr Asp Leu Leu
 545                 550                 555                 560

 gaa acc ctg agg aga ctt tct gtc acc tcc aag gtg aag ttc atc gtc     1907
 Glu Thr Leu Arg Arg Leu Ser Val Thr Ser Lys Val Lys Phe Ile Val
                 565                 570                 575

 ttc aat ccg tcc ttt gta tac atg gat cga tat gcc tcc tct ctg gga     1955
 Phe Asn Pro Ser Phe Val Tyr Met Asp Arg Tyr Ala Ser Ser Leu Gly
             580                 585                 590

 gcc ccc ctg cac aac tcc tgc atc agt gct ttg ttc ctg ctc ttc ttc     2003
 Ala Pro Leu His Asn Ser Cys Ile Ser Ala Leu Phe Leu Leu Phe Phe
         595                 600                 605

 tcg gca ttc ctg gtg gca gat tca ctg att aac gtc tgg atc act ctc     2051
 Ser Ala Phe Leu Val Ala Asp Ser Leu Ile Asn Val Trp Ile Thr Leu
     610                 615                 620

 aca gtt gtg tcc gtg gag ttt gga gtg ata ggt ttc atg aca tta tgg     2099
 Thr Val Val Ser Val Glu Phe Gly Val Ile Gly Phe Met Thr Leu Trp
 625                 630                 635                 640

 aaa gta gaa ctg gac tgc att tct gtg cta tgc tta att tat gga att     2147
 Lys Val Glu Leu Asp Cys Ile Ser Val Leu Cys Leu Ile Tyr Gly Ile
                 645                 650                 655

 aat tac aca att gac aat tgt gct cca atg tta tcc aca ttt gtt ctg     2195
 Asn Tyr Thr Ile Asp Asn Cys Ala Pro Met Leu Ser Thr Phe Val Leu
             660                 665                 670

 ggc aag gat ttc aca aga act aaa tgg gta aaa aat gcc ctg gaa gtg     2243
 Gly Lys Asp Phe Thr Arg Thr Lys Trp Val Lys Asn Ala Leu Glu Val
         675                 680                 685

 cat ggg gta gct att tta cag agt tac ctc tgc tat att gtt ggt ctg     2291
 His Gly Val Ala Ile Leu Gln Ser Tyr Leu Cys Tyr Ile Val Gly Leu
     690                 695                 700

 att cct ctt gca gct gtg cct tca aat ctg acc tgt aca ctg ttc agg     2339
 Ile Pro Leu Ala Ala Val Pro Ser Asn Leu Thr Cys Thr Leu Phe Arg
 705                 710                 715                 720

 tgc ttg ttt tta ata gca ttt gtc acc ttc ttt cac tgc ttt gcc att     2387
 Cys Leu Phe Leu Ile Ala Phe Val Thr Phe Phe His Cys Phe Ala Ile
                 725                 730                 735

 tta cct gtg ata ctg act ttc ctg cca ccc tct aag aaa aaa agg aaa     2435
 Leu Pro Val Ile Leu Thr Phe Leu Pro Pro Ser Lys Lys Lys Arg Lys
             740                 745                 750

 gag aag aaa aat cct gag aac cgg gag gaa att gag tgt gta gaa atg     2483
 Glu Lys Lys Asn Pro Glu Asn Arg Glu Glu Ile Glu Cys Val Glu Met
         755                 760                 765

 gta gat atc gat agt acc cgt gtg gtt gac caa att aca aca gtg tga     2531
 Val Asp Ile Asp Ser Thr Arg Val Val Asp Gln Ile Thr Thr Val 
     770                 775                 780

 taatgtctgc ttggcatatt ttcaccttag gtttatcaga acaagagatt tgttatgaaa   2591

 cattaattcc aaggtcttcc ctttaaagat tgaacggttg gcaaaaaaaa aa           2643




      <210> 131
      <211> 1103
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (137)..(754)

      <400> 131
 gctcggatct aggagctact cgcccggccc tgggcggtgg gaggcggcgg cggcggcggc     60

 gctcgcgcac ctcggaggag ccaggagccg gaaccagggc cgagcccgcg ggccggggct    120

 agccagccgg tcggag    atg tcc gcc cag agg tta att tct aac aga acc     169
                      Met Ser Ala Gln Arg Leu Ile Ser Asn Arg Thr
                        1               5                  10

 tcc cag caa tcg gca tct aat tct gat tac acc tgg gaa tat gaa tat      217
 Ser Gln Gln Ser Ala Ser Asn Ser Asp Tyr Thr Trp Glu Tyr Glu Tyr
              15                  20                  25

 tat gag att gga cca gtt tcc ttt gaa gga ctg aag gct cat aaa tat      265
 Tyr Glu Ile Gly Pro Val Ser Phe Glu Gly Leu Lys Ala His Lys Tyr
          30                  35                  40

 tcc att gtg att gga ttt tgg gtt ggt ctt gca gtc ttc gtg att ttt      313
 Ser Ile Val Ile Gly Phe Trp Val Gly Leu Ala Val Phe Val Ile Phe
      45                  50                  55

 atg ttt ttt gtg ctg acc ttg ctg acc aag aca gga gcc cca cac caa      361
 Met Phe Phe Val Leu Thr Leu Leu Thr Lys Thr Gly Ala Pro His Gln
  60                  65                  70                  75

 gac aat gca gag tcc tca gag aag aga ttc aga atg aac agc ttt gtg      409
 Asp Asn Ala Glu Ser Ser Glu Lys Arg Phe Arg Met Asn Ser Phe Val
                  80                  85                  90

 tca gac ttt gga aga cct ctg gag cca gat aaa gta ttt tct cgc caa      457
 Ser Asp Phe Gly Arg Pro Leu Glu Pro Asp Lys Val Phe Ser Arg Gln
              95                 100                 105

 ggc aac gag gag tcc agg tct ctc ttt cac tgc tac atc aat gag gtg      505
 Gly Asn Glu Glu Ser Arg Ser Leu Phe His Cys Tyr Ile Asn Glu Val
         110                 115                 120

 gaa cgc ttg gac aga gcc aaa gct tgt cac cag acc aca gcc ctt gac      553
 Glu Arg Leu Asp Arg Ala Lys Ala Cys His Gln Thr Thr Ala Leu Asp
     125                 130                 135

 agt gac gtc caa ctc cag gaa gcc atc aga agc agt ggg cag cca gag      601
 Ser Asp Val Gln Leu Gln Glu Ala Ile Arg Ser Ser Gly Gln Pro Glu
 140                 145                 150                 155

 gag gag ctg aac agg ctc atg aag ttt gac atc ccc aac ttt gtg aac      649
 Glu Glu Leu Asn Arg Leu Met Lys Phe Asp Ile Pro Asn Phe Val Asn
                 160                 165                 170

 aca gac cag aac tac ttt ggg gag gat gat ctt ctg att tct gaa cca      697
 Thr Asp Gln Asn Tyr Phe Gly Glu Asp Asp Leu Leu Ile Ser Glu Pro
             175                 180                 185

 cct att gtt ctg gaa act aag cca ctt tcc cag acc tca cac aaa gac      745
 Pro Ile Val Leu Glu Thr Lys Pro Leu Ser Gln Thr Ser His Lys Asp
         190                 195                 200

 ctg gat tga gaaacat gctctgtaaa gggtcttcct gaagatgtgg attctatctt      801
 Leu Asp 
     205

 tatgtagcaa gaaatctaca tccaccaaaa ttgtgtgtgt ttgggggaga gagagacata    861

 gagatagaga cagagaggca gagaagagac ccctttagaa gagagctgag ctgattaagc    921

 tgagtggttt tttgttttgt tttgtttttg ctttttaata catttggagc tttgggagta    981

 ttaaagtatt tacaccaagc ttgtccaacc cgtggcatgt gtgccaagac atctttgaat   1041

 gggggcccat cgccctttag aactgtttta ccacctgagc tttggttgtt ttgcagagag   1101

 ga                                                                  1103




      <210> 132
      <211> 879
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (281)..(829)

      <400> 132
 ggcggagccg acatcacggc cggggtcgtt gctgtttaga cgcctgggtt cccggatccc     60

 agacacgcgc acgggcagga agttagaccg gagacagcga gtatagacag cccttctgga    120

 taggggcaga cgggtgggag ctccgaaggg gtgccggggc ggtgatcggg aggtctccag    180

 cggcccgaac caggtgaaga agaagcccgg gtttccgctt ccctccgggc gcgagaagag    240

 gggagccagg ccgagccccg gccctaccgc cgccgccgcc  atg tgg ccc cca gac     295
                                              Met Trp Pro Pro Asp
                                                1               5

 ccc gac ccc gac ccg gac ccc gag cct gcc ggc ggc tcc cgt ccc ggc      343
 Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly Gly Ser Arg Pro Gly
                  10                  15                  20

 ccc gcg gtc ccc ggg ctc cgc gcc ctg ctg ccg gcg cgg gct ttc ctc      391
 Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro Ala Arg Ala Phe Leu
              25                  30                  35

 tgc tct ctc aaa ggc cgc ctc ctg ctg gcc gag tcg ggt ctc tca ttc      439
 Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu Ser Gly Leu Ser Phe
          40                  45                  50

 atc act ttt atc tgc tat gtg gcg tcc tca gca tct gcc ttc ctc aca      487
 Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala Ser Ala Phe Leu Thr
      55                  60                  65

 gcg cct ctg ctg gag ttc ctg ctg gcc ttg tac ttc ctc ttt gct gat      535
 Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr Phe Leu Phe Ala Asp
  70                  75                  80                  85

 gcc atg cag ctg aat gac aag tgg cag ggc ttg tgc tgg ccc atg atg      583
 Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu Cys Trp Pro Met Met
                  90                  95                 100

 gac ttc ctg cgc tgt gtc acc gcg gcc ctc atc tac ttt gct atc tcc      631
 Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile Tyr Phe Ala Ile Ser
             105                 110                 115

 atc acg gcc atc gcc aag tac tcg gat ggg gct tcc aaa gcc gct ggg      679
 Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala Ser Lys Ala Ala Gly
         120                 125                 130

 gtg ttt ggc ttc ttt gct acc atc gtg ttt gca act gat ttc tac ctg      727
 Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala Thr Asp Phe Tyr Leu
     135                 140                 145

 atc ttt aac gac gtg gcc aaa ttc ctc aaa caa ggg gac tct gca gat      775
 Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln Gly Asp Ser Ala Asp
 150                 155                 160                 165

 gag acc aca gcc cac aag aca gaa gaa gag aat tcc gac tcg gac tct      823
 Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn Ser Asp Ser Asp Ser
                 170                 175                 180

 gac tga aggcctggcg ggtgccttgg caacctgagc cacacaggcc tccacccctg       879
 Asp 






      <210> 133
      <211> 2110
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (661)..(1257)

      <400> 133
 atttgctttt tacattttac cccttcaagg aaggtgcctt ctgtctgtgt cttctacagc     60

 cagctctctc actgcacctt ctctctgttc ctttccggat tatgaggcat ctgcctgagg    120

 gaagtgggtg gtgtggtcag gggtgctgcc tttcttcctc gagagcaagt tgccaaaacc    180

 taagccagcc atttttggca ctcactgtca actctggtaa aatactggct ggggagggaa    240

 tatagggaat tgtgcttggg ggatcctgaa tgtcttctat taaagcgcct gctttatctg    300

 tgtgttggca gggatgactg caaacatcct ctcggcatct ctgtcagcat gggctttggc    360

 tatattaagt gcttactgtg cttctggcat ttcacatttt gggagccacc gggattgatt    420

 gtcctcgata gagacttgga tacctgtttt cctaagctgg tgtctttctc tcactggaga    480

 atcatagtgt tgctggatgc ataaatatga agctgtggtc tctgacaaga cttgtgttag    540

 cagattgatg ttcaggcttc agtatcctcc tgacttaaca aacaattaca ttattcattc    600

 aggaaacctt attcagcacc cactaggtgc tcaggttctc tgcaaaggac acagaaatga    660
                                                                 
 atg ata cgt gtt cct tgc ata tgg cac tgt cta gag ggg aca tac aca      708
 Met Ile Arg Val Pro Cys Ile Trp His Cys Leu Glu Gly Thr Tyr Thr
   1               5                  10                  15

 gct gaa gaa ggg aag ggc agt gat ggg gtt atg gag gaa gta tgg cag      756
 Ala Glu Glu Gly Lys Gly Ser Asp Gly Val Met Glu Glu Val Trp Gln
              20                  25                  30

 gga aag cag gag ggt gat gct gga aga caa atg gta gat ccc agg cgg      804
 Gly Lys Gln Glu Gly Asp Ala Gly Arg Gln Met Val Asp Pro Arg Arg
          35                  40                  45

 act gga aag aat tgc aat agg ggg agc cgg gga gtg cag tct gtg aga      852
 Thr Gly Lys Asn Cys Asn Arg Gly Ser Arg Gly Val Gln Ser Val Arg
      50                  55                  60

 ggc tgg aaa tgt gaa agc cag gag ctc tca ggg att tgg gtt gcc tcc      900
 Gly Trp Lys Cys Glu Ser Gln Glu Leu Ser Gly Ile Trp Val Ala Ser
  65                  70                  75                  80

 tgc aca gtc aag gag agt gtc act cag gct agt cat aga tgg cat acc      948
 Cys Thr Val Lys Glu Ser Val Thr Gln Ala Ser His Arg Trp His Thr
                  85                  90                  95

 tac agg ctt ggg ctg att tta gat agt tgt tca gag cag tca ggc agg      996
 Tyr Arg Leu Gly Leu Ile Leu Asp Ser Cys Ser Glu Gln Ser Gly Arg
             100                 105                 110

 cgc cag agg cac aag ccc tgt gag agg tgt gtt tgg aat cac ttg gta     1044
 Arg Gln Arg His Lys Pro Cys Glu Arg Cys Val Trp Asn His Leu Val
         115                 120                 125

 tcc aaa tca cat gtc atc cct agg agc aag gag acc ggt tgg att tgg     1092
 Ser Lys Ser His Val Ile Pro Arg Ser Lys Glu Thr Gly Trp Ile Trp
     130                 135                 140

 ggc tgg tct gga atg aag aag cat ctc tca gct tcc gaa ggc tgc atg     1140
 Gly Trp Ser Gly Met Lys Lys His Leu Ser Ala Ser Glu Gly Cys Met
 145                 150                 155                 160

 gct cac ggc agt atc tca atc atg ccc tgc ccg ttt gca cat ttg gtc     1188
 Ala His Gly Ser Ile Ser Ile Met Pro Cys Pro Phe Ala His Leu Val
                 165                 170                 175

 ctg ttg gta gtt acc tct ctg gtg act ggc aaa gtc agc aag gat att     1236
 Leu Leu Val Val Thr Ser Leu Val Thr Gly Lys Val Ser Lys Asp Ile
             180                 185                 190

 ggg gtg gag cac cct ggc taa gc accctcttga ttatagagct atggagtaga     1289
 Gly Val Glu His Pro Gly 
         195

 agacagatgg agaatgagag gcctgtgaga acaatcagtc agttgccatc tttcagagct   1349

 gctcgagttc aaaagtgtgt catacagggt attttaacat tgctaccttt aagggattca   1409

 ggtgggaacc ctatgctgtg gcttcacata atggaacttg ggtgccatcc taccctgtga   1469

 tgttgagctg gccagcactg gtgtaggaac ctcaaggact ctgtgctcct ctggtttggg   1529

 gcctaggata aacacaggcc ctgcttgccc cttggttcta ggacacatct tcccatgcca   1589

 gcaaagttaa tgaaccagtc tacaagataa ctgttgaaag aattcttaga gaaacaaccc   1649

 acaggagggg agccatgtca gagcccaaga aaaccatccc atcctgagct ctgccttctg   1709

 tgctgctctc tgcatcctat tctctgtcgg aacaggaccc cactgtgtcc ttgctcttct   1769

 aggcagagtt gtgggagagt gctaaatgct tttgagtggg gcagcctgtg gaatgggatc   1829

 tcatactggc tccttagacc ttgggcccat gaactcagta tggagcagga cctgcgatgt   1889

 tctgatggat tatacccaca gtgtattttg gcacatctgc caaaagctac aaacaacccc   1949

 caacaactac acactatatc ttgtgagaag tgtcctaccc aggagtcctg aatgtgatct   2009

 gagtatgctc taaggcagcc ccaggaaaag caattcagtc cctctctctt tgcctttaga   2069

 cctgcaggtt gggacaatga aaagaaaata gctattttac a                       2110




      <210> 134
      <211> 3925
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (182)..(2713)

      <400> 134
 cgatgctgtg gaacccgaac cgcaccggag tcggctgccg cgcgccaagc ctcccctcac     60

 ctctgctccc ggaaccgcag cgccaaagct gccgctgagc ccctggggga tgcccgccgg    120

 cctcaccgaa cccgccggcg ccgctccccc ggctgctgtg agcgcctcgg ggaccgtgac    180

 c    atg gcc ccg gcc ggg gcg ctg ccg gtg cgg gtg gag agc act ccg     226
      Met Ala Pro Ala Gly Ala Leu Pro Val Arg Val Glu Ser Thr Pro
        1               5                  10                  15

 gtg gcc ctg ggc gcc gtg act aag gct cct gtc agc gtc tgc gtg gag      274
 Val Ala Leu Gly Ala Val Thr Lys Ala Pro Val Ser Val Cys Val Glu
                  20                  25                  30

 ccc acg gcg tcc cag ccc ctg cgg tcc ccc gtg ggg acc ctg gtg acc      322
 Pro Thr Ala Ser Gln Pro Leu Arg Ser Pro Val Gly Thr Leu Val Thr
              35                  40                  45

 aaa gtg gct ccg gtc agc gcc cct cct aaa gtc agc agc ggc cct agg      370
 Lys Val Ala Pro Val Ser Ala Pro Pro Lys Val Ser Ser Gly Pro Arg
          50                  55                  60

 ctg cct gct cct cag ata gtc gcc gtg aaa gcc ccc aac acc acg aca      418
 Leu Pro Ala Pro Gln Ile Val Ala Val Lys Ala Pro Asn Thr Thr Thr
      65                  70                  75

 atc cag ttt cct gct aat ttg cag ctt cct cca gga acc gtt ttg att      466
 Ile Gln Phe Pro Ala Asn Leu Gln Leu Pro Pro Gly Thr Val Leu Ile
  80                  85                  90                  95

 aaa agt aac agt ggt ccg ttg atg ttg gta tct cct cag caa act gta      514
 Lys Ser Asn Ser Gly Pro Leu Met Leu Val Ser Pro Gln Gln Thr Val
                 100                 105                 110

 aca aga gcc gag acc aca agt aac ata acc tca agg cca gca gta cca      562
 Thr Arg Ala Glu Thr Thr Ser Asn Ile Thr Ser Arg Pro Ala Val Pro
             115                 120                 125

 gcg aat cct caa aca gtc aaa atc tgt aca gtg ccg aac tct agc tca      610
 Ala Asn Pro Gln Thr Val Lys Ile Cys Thr Val Pro Asn Ser Ser Ser
         130                 135                 140

 caa tta atc aag aaa gtg gca gtg aca cct gtt aaa aaa ttg gca caa      658
 Gln Leu Ile Lys Lys Val Ala Val Thr Pro Val Lys Lys Leu Ala Gln
     145                 150                 155

 ata gga act act gtg gta acc act gtt ccg aag cct tcc tca gta caa      706
 Ile Gly Thr Thr Val Val Thr Thr Val Pro Lys Pro Ser Ser Val Gln
 160                 165                 170                 175

 tct gtg gct gtg cca acc agt gtc gtc aca gtt act cct gga aag cca      754
 Ser Val Ala Val Pro Thr Ser Val Val Thr Val Thr Pro Gly Lys Pro
                 180                 185                 190

 ttg aat act gta act acc ctg aag cct tca agt ttg gga gca tca tcc      802
 Leu Asn Thr Val Thr Thr Leu Lys Pro Ser Ser Leu Gly Ala Ser Ser
             195                 200                 205

 act cct tca aat gag ccc aat ctt aaa gca gag aac tca gca gct gtt      850
 Thr Pro Ser Asn Glu Pro Asn Leu Lys Ala Glu Asn Ser Ala Ala Val
         210                 215                 220

 cag att aat ctt tct ccg aca atg cta gaa aat gtg aag aaa tgc aag      898
 Gln Ile Asn Leu Ser Pro Thr Met Leu Glu Asn Val Lys Lys Cys Lys
     225                 230                 235

 aac ttc ctt gca atg tta ata aaa cta gca tgt agt gga tca cag tcc      946
 Asn Phe Leu Ala Met Leu Ile Lys Leu Ala Cys Ser Gly Ser Gln Ser
 240                 245                 250                 255

 cca gaa atg ggg caa aat gtg aag aag ctg gtg gaa caa ctt ttg gat      994
 Pro Glu Met Gly Gln Asn Val Lys Lys Leu Val Glu Gln Leu Leu Asp
                 260                 265                 270

 gca aaa atc gaa gca gaa gaa ttt act agg aaa ctg tat gtt gaa ctc     1042
 Ala Lys Ile Glu Ala Glu Glu Phe Thr Arg Lys Leu Tyr Val Glu Leu
             275                 280                 285

 aag tct tca cct cag cct cac ctg gtt cct ttt ctt aag aaa agt gtg     1090
 Lys Ser Ser Pro Gln Pro His Leu Val Pro Phe Leu Lys Lys Ser Val
         290                 295                 300

 gtt gcc tta cga caa ctt ctg cct aac tcc cag agc ttc atc cag caa     1138
 Val Ala Leu Arg Gln Leu Leu Pro Asn Ser Gln Ser Phe Ile Gln Gln
     305                 310                 315

 tgt gtt cag cag act tct agt gac atg gtc att gct acc tgt act aca     1186
 Cys Val Gln Gln Thr Ser Ser Asp Met Val Ile Ala Thr Cys Thr Thr
 320                 325                 330                 335

 aca gta aca act tct cct gtg gtg aca act aca gtg tcc tca agc cag     1234
 Thr Val Thr Thr Ser Pro Val Val Thr Thr Thr Val Ser Ser Ser Gln
                 340                 345                 350

 tct gaa aag tca att att gtt tct gga gca aca gca ccc aga act gtg     1282
 Ser Glu Lys Ser Ile Ile Val Ser Gly Ala Thr Ala Pro Arg Thr Val
             355                 360                 365

 tca gtg caa act ttg aac cca ctt gct ggt cca gtg gga gca aaa gct     1330
 Ser Val Gln Thr Leu Asn Pro Leu Ala Gly Pro Val Gly Ala Lys Ala
         370                 375                 380

 gga gtt gtg aca ctt cat tct gtg ggc cca act gct gca aca gga gga     1378
 Gly Val Val Thr Leu His Ser Val Gly Pro Thr Ala Ala Thr Gly Gly
     385                 390                 395

 aca aca gct gga act ggt ttg ctt cag act tca aaa cca ctt gtg aca     1426
 Thr Thr Ala Gly Thr Gly Leu Leu Gln Thr Ser Lys Pro Leu Val Thr
 400                 405                 410                 415

 tct gtg gca aac aca gtg acc acg gtc tca ctg caa cct gaa aag cca     1474
 Ser Val Ala Asn Thr Val Thr Thr Val Ser Leu Gln Pro Glu Lys Pro
                 420                 425                 430

 gtt gtc tct gga aca gca gta aca ctg tcc ctt cca gca gta act ttt     1522
 Val Val Ser Gly Thr Ala Val Thr Leu Ser Leu Pro Ala Val Thr Phe
             435                 440                 445

 gga gaa act tca ggt gca gct att tgt ctt cca tct gtg aaa cct gtt     1570
 Gly Glu Thr Ser Gly Ala Ala Ile Cys Leu Pro Ser Val Lys Pro Val
         450                 455                 460

 gtt tct tct gct ggg acc aca tct gac aag cct gtt att ggg act cca     1618
 Val Ser Ser Ala Gly Thr Thr Ser Asp Lys Pro Val Ile Gly Thr Pro
     465                 470                 475

 gtt caa atc aaa ctt gcc cag ccg ggc cct gtc ctt tca caa cca gct     1666
 Val Gln Ile Lys Leu Ala Gln Pro Gly Pro Val Leu Ser Gln Pro Ala
 480                 485                 490                 495

 ggg att cca cag gca gtt caa gtc aag caa cta ttc tca ttg ttt cac     1714
 Gly Ile Pro Gln Ala Val Gln Val Lys Gln Leu Phe Ser Leu Phe His
                 500                 505                 510

 gta gtt cag cag cct tca gga ggc aat gaa aaa caa gtg acc aca att     1762
 Val Val Gln Gln Pro Ser Gly Gly Asn Glu Lys Gln Val Thr Thr Ile
             515                 520                 525

 tca cat tcc tca aca ttg acc att cag aaa tgt gga cag aag acg atg     1810
 Ser His Ser Ser Thr Leu Thr Ile Gln Lys Cys Gly Gln Lys Thr Met
         530                 535                 540

 cca gtg aac acc ata ata cct act agt cag ttt cct cca gct tcc att     1858
 Pro Val Asn Thr Ile Ile Pro Thr Ser Gln Phe Pro Pro Ala Ser Ile
     545                 550                 555

 cta aag caa att act ctg cct gga aat aaa att ctg tca ctt caa gca     1906
 Leu Lys Gln Ile Thr Leu Pro Gly Asn Lys Ile Leu Ser Leu Gln Ala
 560                 565                 570                 575

 tct cct act cag aaa aac aga ata aaa gag aat gta aca tca tgc ttc     1954
 Ser Pro Thr Gln Lys Asn Arg Ile Lys Glu Asn Val Thr Ser Cys Phe
                 580                 585                 590

 cga gat gag gat gac atc aat gat gtg act tct atg gca ggg gtc aac     2002
 Arg Asp Glu Asp Asp Ile Asn Asp Val Thr Ser Met Ala Gly Val Asn
             595                 600                 605

 ctt aat gaa gaa aat gcc tgc atc tta gca aca aac tct gaa ttg gtt     2050
 Leu Asn Glu Glu Asn Ala Cys Ile Leu Ala Thr Asn Ser Glu Leu Val
         610                 615                 620

 ggc aca ctc att cag tca tgt aaa gat gaa cca ttt ctt ttt att gga     2098
 Gly Thr Leu Ile Gln Ser Cys Lys Asp Glu Pro Phe Leu Phe Ile Gly
     625                 630                 635

 gct cta caa aag aga att tta gac att ggt aaa aag cat gac att aca     2146
 Ala Leu Gln Lys Arg Ile Leu Asp Ile Gly Lys Lys His Asp Ile Thr
 640                 645                 650                 655

 gaa ctt aac tct gat gct gtg aac ttg atc tcc caa gca aca cag gaa     2194
 Glu Leu Asn Ser Asp Ala Val Asn Leu Ile Ser Gln Ala Thr Gln Glu
                 660                 665                 670

 cga cta cga ggc ctt cta gaa aaa ctg act gca att gct cag cat cga     2242
 Arg Leu Arg Gly Leu Leu Glu Lys Leu Thr Ala Ile Ala Gln His Arg
             675                 680                 685

 atg act act tac aag gca agt gaa aat tac atc ctg tgt agt gat acc     2290
 Met Thr Thr Tyr Lys Ala Ser Glu Asn Tyr Ile Leu Cys Ser Asp Thr
         690                 695                 700

 agg tca cag ctc aaa ttt ctt gaa aag ctg gat caa ttg gag aag cag     2338
 Arg Ser Gln Leu Lys Phe Leu Glu Lys Leu Asp Gln Leu Glu Lys Gln
     705                 710                 715

 aga aag gat ttg gaa gaa aga gaa atg tta ctt aag gca gcc aag agt     2386
 Arg Lys Asp Leu Glu Glu Arg Glu Met Leu Leu Lys Ala Ala Lys Ser
 720                 725                 730                 735

 cgt tct aat aaa gaa gat cca gaa cag ctg aga tta aag cag aaa gcc     2434
 Arg Ser Asn Lys Glu Asp Pro Glu Gln Leu Arg Leu Lys Gln Lys Ala
                 740                 745                 750

 aaa gag tta cag caa ttg gaa ctt gca cag ata cag cat aga gac gct     2482
 Lys Glu Leu Gln Gln Leu Glu Leu Ala Gln Ile Gln His Arg Asp Ala
             755                 760                 765

 aat ctc aca gct ctt gca gct att gga cca agg aag aag aga cca cta     2530
 Asn Leu Thr Ala Leu Ala Ala Ile Gly Pro Arg Lys Lys Arg Pro Leu
         770                 775                 780

 gaa tct gga att gag ggc tta aaa gac aac ctt ctt gct tct ggg aca     2578
 Glu Ser Gly Ile Glu Gly Leu Lys Asp Asn Leu Leu Ala Ser Gly Thr
     785                 790                 795

 tcc agc ctg aca gcc acc aaa cag ttg cat cgt cca aga atc acg aga     2626
 Ser Ser Leu Thr Ala Thr Lys Gln Leu His Arg Pro Arg Ile Thr Arg
 800                 805                 810                 815

 atc tgc ctc agg gac ttg ata ttt tgt atg gaa cag gaa cgg gag atg     2674
 Ile Cys Leu Arg Asp Leu Ile Phe Cys Met Glu Gln Glu Arg Glu Met
                 820                 825                 830

 aag tat tct cga gct cta tac ctg gcc ctt ctg aag tga ccactccact      2723
 Lys Tyr Ser Arg Ala Leu Tyr Leu Ala Leu Leu Lys 
             835                 840

 cttccatcca gatccttgct atttactgcc aaagaagaca caaagcattg ttgcactgtc   2783

 ctgaaatttc aatttctgga aaataatcac caacatgaaa gagcattgtt tacagttaga   2843

 aactttatta actcttacct atccatctca tgggactctt acagactcag attcatcttt   2903

 gtcttctgaa aatcagttat gaaatacact ttgcacagaa ttaggcatct gcctatctgt   2963

 gcattaaatt aaagcaagtt aaggccctat ttgttactac ctgcctcatt tgccaaattg   3023

 tagcaggtga ggtgtccttc cctaatacag catgcattga gatgcaggag aaaggaagag   3083

 gcataagaaa atacaagaat gactatttca ttctatattg aacctgtccc aaagtggtag   3143

 gttttctggg ctggaatcag aagttgctta gctaactatg acagtcaccc tctgtacgtg   3203

 acaggccact gtggtgactt tggtcggctg agttccagtg ttgtcaaaac aagacaaatg   3263

 gggatagatt gtgcctgggg ttgctaattc tctgcttcat atcaccatat gccgtttctg   3323

 gtaccaagtg aggggacatg cttgtcaggg aaaccttaaa attgaatcta ctgatatatc   3383

 ttgttgaaaa aatggaaaag gtgcaaagta ttagaaggaa cgttagggcg ttgctttcaa   3443

 actgatgagg ggaatgtgaa aatggtatca taaaacagga aatgtgcttc atatgcccaa   3503

 gaggggaaga ggtggaatcg gaactccaaa acaactggta catgttttgt tgatgggcaa   3563

 aaaaaatcac agcacaacca gaaaggagaa tgtaccagat gttttcaaat tagagtattt   3623

 caaaaggaaa atgttatttt ttgttttgta ttgttttaaa tcccaaggat agtttttata   3683

 tttccttctg tcataatata ttttagttat cctaattttt aagcatgttg gcacatttaa   3743

 aaaatcctaa ttgatgatga gaaattttta acaataggac tttatgttgg attctgtact   3803

 taaaaggtac tgtcaatatc tcactcttgg ggatatgagc tctaaatatg agaagcaagt   3863

 tatatgtgtt cacctgagga agaagctgac ggacaaagca aaccctcttt aaaaaaaaaa   3923

 aa                                                                  3925




      <210> 135
      <211> 1380
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (389)..(1333)

      <400> 135
 gcgataaact acccttctgg ccgagggccc ggcagaacgg agtttgagaa gcatcgtggc     60

 tttctggccc aggaggagca acggcagctg aggcggctgg aggcggagga gcgagcgacg    120

 ctgcagagac tgcgggagag caagagccgg ctggtccagc agagcaaggc cctgaaggag    180

 ctggcggatg agctgcagga gaggtgccag cgcccggccc tgggtctgct ggagggtgtg    240

 agaggagtcc tgagcagaag taaggctgtc acaaggctgg aagcagagaa catccccatg    300

 gaactgaaga cagcatgctg catccctggg aggagggagc tcttaaggaa gttccaagga    360

 ttgatatttc tgttcagctg cagtaaag   atg gat gga acc aat ggc agc acc     412
                                  Met Asp Gly Thr Asn Gly Ser Thr
                                    1               5

 caa acc cat ttc atc cta ctg gga ttc tct gac cga ccc cat ctg gag      460
 Gln Thr His Phe Ile Leu Leu Gly Phe Ser Asp Arg Pro His Leu Glu
      10                  15                  20

 agg atc ctc ttt gtg gtc atc ctg atc gcg tac ctc ctg acc ctc gta      508
 Arg Ile Leu Phe Val Val Ile Leu Ile Ala Tyr Leu Leu Thr Leu Val
  25                  30                  35                  40

 ggc aac acc acc atc atc ctg gtg tcc cgg ctg gac ccc cac ctc cac      556
 Gly Asn Thr Thr Ile Ile Leu Val Ser Arg Leu Asp Pro His Leu His
                  45                  50                  55

 acc ccc atg tac ttc ttc ctc gcc cac ctt tcc ttc ctg gac ctc agt      604
 Thr Pro Met Tyr Phe Phe Leu Ala His Leu Ser Phe Leu Asp Leu Ser
              60                  65                  70

 ttc acc acc agc tcc atc ccc cag ctg ctc tac aac ctt aat gga tgt      652
 Phe Thr Thr Ser Ser Ile Pro Gln Leu Leu Tyr Asn Leu Asn Gly Cys
          75                  80                  85

 gac aag acc atc agc tac atg ggc tgt gcc atc cag ctc ttc ctg ttc      700
 Asp Lys Thr Ile Ser Tyr Met Gly Cys Ala Ile Gln Leu Phe Leu Phe
      90                  95                 100

 ctg ggt ctg ggt ggt gtg gag tgc ctg ctt ctg gct gtc atg gcc tat      748
 Leu Gly Leu Gly Gly Val Glu Cys Leu Leu Leu Ala Val Met Ala Tyr
 105                 110                 115                 120

 gac cgg tgt gtg gct atc tgc aag ccc ctg cac tac atg gtg atc atg      796
 Asp Arg Cys Val Ala Ile Cys Lys Pro Leu His Tyr Met Val Ile Met
                 125                 130                 135

 aac ccc agg ctc tgc cgg ggc ttg gtg tca gtg acc tgg ggc tgt ggg      844
 Asn Pro Arg Leu Cys Arg Gly Leu Val Ser Val Thr Trp Gly Cys Gly
             140                 145                 150

 gtg gcc aac tcc ttg gcc atg tct cct gtg acc ctg cgc tta ccc cgc      892
 Val Ala Asn Ser Leu Ala Met Ser Pro Val Thr Leu Arg Leu Pro Arg
         155                 160                 165

 tgt ggg cac cac gag gtg gac cac ttc ctg cgt gag atg ccc gcc ctg      940
 Cys Gly His His Glu Val Asp His Phe Leu Arg Glu Met Pro Ala Leu
     170                 175                 180

 atc cgg atg gcc tgc gtc agc act gtg gcc atc gaa ggc acc gtc ttt      988
 Ile Arg Met Ala Cys Val Ser Thr Val Ala Ile Glu Gly Thr Val Phe
 185                 190                 195                 200

 gtc ctg aaa aaa ggt gtt gtg ctg tcc ccc ttg gtg ttt atc ctg ctc     1036
 Val Leu Lys Lys Gly Val Val Leu Ser Pro Leu Val Phe Ile Leu Leu
                 205                 210                 215

 tct tac agc tac att gtg agg gct gtg tta caa att cgg tca gca tca     1084
 Ser Tyr Ser Tyr Ile Val Arg Ala Val Leu Gln Ile Arg Ser Ala Ser
             220                 225                 230

 gga agg cag aag gcc ttc ggc acc tgc ggc tcc cat ctc act gtg gtc     1132
 Gly Arg Gln Lys Ala Phe Gly Thr Cys Gly Ser His Leu Thr Val Val
         235                 240                 245

 tcc ctt ttc tat gga aac atc atc tac atg tac atg cag cca gga gcc     1180
 Ser Leu Phe Tyr Gly Asn Ile Ile Tyr Met Tyr Met Gln Pro Gly Ala
     250                 255                 260

 agt tct tcc cag gac cag ggc aag ttc ctc acg ctc ttc tac aac att     1228
 Ser Ser Ser Gln Asp Gln Gly Lys Phe Leu Thr Leu Phe Tyr Asn Ile
 265                 270                 275                 280

 gtc acc ccc ctc ctc aat cct ctc atc tac acc ctc aga aac aga gag     1276
 Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Arg Glu
                 285                 290                 295

 gtg aag ggg gca ctg gga agg ttg ctt ctg ggg aag aga gag cta gga     1324
 Val Lys Gly Ala Leu Gly Arg Leu Leu Leu Gly Lys Arg Glu Leu Gly
             300                 305                 310

 aag gag taa aggcatc tccacctgac ttcacctcca tccagggcca ctggcagcat     1380
 Lys Glu 






      <210> 136
      <211> 1957
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (118)..(1152)

      <400> 136
 gcaaagtgct cagcactaag ggagccagcg cacagcacag ccaggaaggc gagcgagccc     60

 agccagccca gccagcccag ccagcccgga ggtcatttga ttgcccgcct cagaacg       117                                                                 
 atg gat ctg cat ctc ttc gac tac tca gag cca ggg aac ttc tcg gac      165
 Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp
   1               5                  10                  15

 atc agc tgg cca tgc aac agc agc gac tgc atc gtg gtg gac acg gtg      213
 Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val
              20                  25                  30

 atg tgt ccc aac atg ccc aac ggc atg att gcc aac tcc gtg gtg gtc      261
 Met Cys Pro Asn Met Pro Asn Gly Met Ile Ala Asn Ser Val Val Val
          35                  40                  45

 tgg gtg aat atc cag gcc aag acc aca ggc tat gac acg cac tgc tac      309
 Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His Cys Tyr
      50                  55                  60

 atc ttg aac ctg gcc att gcc gac ctg tgg gtt gtc ctc acc atc cca      357
 Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr Ile Pro
  65                  70                  75                  80

 gtc tgg gtg gtc agt ctc gtg cag cac aac cag tgg ccc atg ggc gag      405
 Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met Gly Glu
                  85                  90                  95

 ctc acg tgc aaa gtc aca cac ctc atc ttc tcc atc aac ctc ttc ggc      453
 Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu Phe Gly
             100                 105                 110

 agc att ttc ttc ctc acg tgc atg agc gtg gac cgc tac ctc tcc atc      501
 Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu Ser Ile
         115                 120                 125

 acc tac ttc acc aac acc ccc agc agc agg aag aag atg gta cgc cgt      549
 Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val Arg Arg
     130                 135                 140

 gtc gtc tgc atc ctg gtg tgg ctg ctg gcc ttc tgc gtg tct ctg cct      597
 Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser Leu Pro
 145                 150                 155                 160

 gac acc tac tac ctg aag acc gtc acg tct gcg tcc aac aat gag acc      645
 Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn Glu Thr
                 165                 170                 175

 tac tgc cgg tcc ttc tac ccc gag cac agc atc aag gag tgg ctg atc      693
 Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp Leu Ile
             180                 185                 190

 ggc atg gag ctg gtc tcc gtt gtc ttg ggc ttt gcc gtt ccc ttc tcc      741
 Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro Phe Ser
         195                 200                 205

 att atc gct gtc ttc tac ttc ctg ctg gcc aga gcc atc tcg gcg tcc      789
 Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser Ala Ser
     210                 215                 220

 agt gac cag gag aag cac agc agc cgg aag atc atc ttc tcc tac gtg      837
 Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser Tyr Val
 225                 230                 235                 240

 gtg gtc ttc ctt gtc tgc tgg ctg ccc tac cac gtg gcg gtg ctg ctg      885
 Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val Leu Leu
                 245                 250                 255

 gac atc ttc tcc atc ctg cac tac atc cct ttc acc tgc cgg ctg gag      933
 Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg Leu Glu
             260                 265                 270

 cac gcc ctc ttc acg gcc ctg cat gtc aca cag tgc ctg tcg ctg gtg      981
 His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser Leu Val
         275                 280                 285

 cac tgc tgc gtc aac cct gtc ctc tac agc ttc atc aat cgc aac tac     1029
 His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg Asn Tyr
     290                 295                 300

 agg tac gag ctg atg aag gcc ttc atc ttc aag tac tcg gcc aaa aca     1077
 Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala Lys Thr
 305                 310                 315                 320

 ggg ctc acc aag ctc atc gat gcc tcc aga gtc tca gag acg gag tac     1125
 Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr Glu Tyr
                 325                 330                 335

 tct gcc ttg gag cag agc acc aaa tga tctgc cctggagagg ctctgggacg     1177
 Ser Ala Leu Glu Gln Ser Thr Lys 
             340

 ggtttacttg tttttgaaca gggtgatggg ccctatggtt ttctagagca aagcaaagta   1237

 gcttcgggtc ttgatgcttg agtagagtga agaggggagc acgtgccccc tgcatccatt   1297

 ctctctttct cttgatgacg cagctgtcat ttggctgtgc gtgctgacag ttttgcaaca   1357

 ggcagagctg tgtcgcacag cagtgctgtg cgtcagagcc agctgaggac aggcttgcct   1417

 ggacttctgt aagataggat tttctgtgtt tcctgaattt tttatatggt gatttgtatt   1477

 taaattttaa gactttattt tctcactatt ggtgtacctt ataaatgtat ttgaaagtta   1537

 aatatatttt aaatattgtt tgggaggcat agtgctgaca tatattcaga gtgttgtagt   1597

 tttaaggtta gcgtgacttc agttttgact aaggatgaca ctaattgtta gctgttttga   1657

 aattatatat atataaatat atataaatat ataaatatat gccagtcttg gctgaaatgt   1717

 tttatttacc atagttttat atctgtgtgg tgttttgtac cggcacggga tatggaacga   1777

 aaactgcttt gtaatgcagt ttgtgacatt aatagtattg taaagttaca ttttaaaata   1837

 aacaaaaaac tgttctggac tgcaaatctg cacacacaac gaacagttgc atttcagaga   1897

 gttctctcaa tttgtaagtt attttttttt aataaagatt tttgtttcct aaaaaaaaaa   1957




      <210> 137
      <211> 2684
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1164)

      <400> 137
  atg ggg ggc ggc ccc gcc gca gga gga ccc ggg cgc gta acc ccg ggg      48
  Met Gly Gly Gly Pro Ala Ala Gly Gly Pro Gly Arg Val Thr Pro Gly
    1               5                  10                  15

 gcc cgg ccc gct cca gac cca gac ccg cgg gcg agc ccc cct tgc acg       96
 Ala Arg Pro Ala Pro Asp Pro Asp Pro Arg Ala Ser Pro Pro Cys Thr
              20                  25                  30

 ctg ccc ccc gcc ccc ggt gtc cgg acg atg ctc aag tct cgg ctc cgc      144
 Leu Pro Pro Ala Pro Gly Val Arg Thr Met Leu Lys Ser Arg Leu Arg
          35                  40                  45

 atg ttt ctg aac gag ctg aag ctg ctg gtg ctg aca ggc ggg ggg cgg      192
 Met Phe Leu Asn Glu Leu Lys Leu Leu Val Leu Thr Gly Gly Gly Arg
      50                  55                  60

 ccc cgg gcc gag ccg caa ccc cgg ggg ggc cgg gga ggc ggc tgc ggc      240
 Pro Arg Ala Glu Pro Gln Pro Arg Gly Gly Arg Gly Gly Gly Cys Gly
  65                  70                  75                  80

 tgg gcg ccc ttc gct ggc tgc tcc acc cgg gac ggc gac ggc gac gag      288
 Trp Ala Pro Phe Ala Gly Cys Ser Thr Arg Asp Gly Asp Gly Asp Glu
                  85                  90                  95

 gag gag tac tac ggg tcg gag ccg cgg gcc cgg ggc ctg gcc ggc gac      336
 Glu Glu Tyr Tyr Gly Ser Glu Pro Arg Ala Arg Gly Leu Ala Gly Asp
             100                 105                 110

 aag gag ccg cgg gcc gga ccc ctg ccg ccg ccc gcg ccg ccg ctg ccg      384
 Lys Glu Pro Arg Ala Gly Pro Leu Pro Pro Pro Ala Pro Pro Leu Pro
         115                 120                 125

 ccc ccg ggc gcg ctg gac gcc ctg tcg ctc agc agt agc ctg gac agc      432
 Pro Pro Gly Ala Leu Asp Ala Leu Ser Leu Ser Ser Ser Leu Asp Ser
     130                 135                 140

 gga ctc cga acc cct cag tgc cgg atc tgc ttc cag ggc ccg gag cag      480
 Gly Leu Arg Thr Pro Gln Cys Arg Ile Cys Phe Gln Gly Pro Glu Gln
 145                 150                 155                 160

 ggg gag ctc tta agc ccc tgc cgc tgc gac ggc tca gtg cgc tgc acg      528
 Gly Glu Leu Leu Ser Pro Cys Arg Cys Asp Gly Ser Val Arg Cys Thr
                 165                 170                 175

 cat cag ccc tgc ctc atc cgc tgg atc agc gag agg ggc tcc tgg agc      576
 His Gln Pro Cys Leu Ile Arg Trp Ile Ser Glu Arg Gly Ser Trp Ser
             180                 185                 190

 tgt gag ctc tgc tac ttc aag tac cag gtc ctg gcg atc agc acc aag      624
 Cys Glu Leu Cys Tyr Phe Lys Tyr Gln Val Leu Ala Ile Ser Thr Lys
         195                 200                 205

 aac cca ctg cag tgg cag gcc atc tcc ctg acg gtc atc gag aag gtc      672
 Asn Pro Leu Gln Trp Gln Ala Ile Ser Leu Thr Val Ile Glu Lys Val
     210                 215                 220

 cag att gct gcc ata gtt ctg ggc tcg ctc ttc ctg gtt gcc agc atc      720
 Gln Ile Ala Ala Ile Val Leu Gly Ser Leu Phe Leu Val Ala Ser Ile
 225                 230                 235                 240

 tcc tgg ctc atc tgg tcc tca ctc agc cct tca gcc aag tgg caa cga      768
 Ser Trp Leu Ile Trp Ser Ser Leu Ser Pro Ser Ala Lys Trp Gln Arg
                 245                 250                 255

 cag gat ctg ctc ttt cag atc tgc tac ggc atg tat ggc ttc atg gat      816
 Gln Asp Leu Leu Phe Gln Ile Cys Tyr Gly Met Tyr Gly Phe Met Asp
             260                 265                 270

 gtc gtc tgc ata ggc ctc atc atc cat gaa ggc tcc tct gtc tac cgc      864
 Val Val Cys Ile Gly Leu Ile Ile His Glu Gly Ser Ser Val Tyr Arg
         275                 280                 285

 atc ttc aag cgc tgg cag gca gtg aac cag cag tgg aag gtc cta aat      912
 Ile Phe Lys Arg Trp Gln Ala Val Asn Gln Gln Trp Lys Val Leu Asn
     290                 295                 300

 tat gac aag acc aag gac ata gga gga gat gca ggg gga ggg acg gca      960
 Tyr Asp Lys Thr Lys Asp Ile Gly Gly Asp Ala Gly Gly Gly Thr Ala
 305                 310                 315                 320

 ggg aag tca ggc ccc agg aac tca cgg acg ggc ccc acc tct ggg gcc     1008
 Gly Lys Ser Gly Pro Arg Asn Ser Arg Thr Gly Pro Thr Ser Gly Ala
                 325                 330                 335

 acg agc cgc ccc cca gct gcc cag cgc atg cgg acg ctc ttg cct cag     1056
 Thr Ser Arg Pro Pro Ala Ala Gln Arg Met Arg Thr Leu Leu Pro Gln
             340                 345                 350

 cgc tgc ggt tat aca atc ttg cac ctc ctt ggg cag ctg cgg cca cca     1104
 Arg Cys Gly Tyr Thr Ile Leu His Leu Leu Gly Gln Leu Arg Pro Pro
         355                 360                 365

 gat gcc cgt tcc agc tcc cat tct ggc cga gag gtt gtc atg agg gtc     1152
 Asp Ala Arg Ser Ser Ser His Ser Gly Arg Glu Val Val Met Arg Val
     370                 375                 380

 act aca gtc tga act ggactccagg agcagggatc ttgagtcaat gcatcagtca     1207
 Thr Thr Val 
 385

 gagaagaact ctcatggctg ctggaggtac cagctggaca aggtgtttgg ggcatgctgc   1267

 ccccgtcacc gaggatctgt gtgggtagcc tcaagctgga gacattgtct ggcctcactg   1327

 cccactgggt agagacacct ggatgacatt tcagtacccg ctggcagctc ctcccactca   1387

 tccagagacg gccggtgggc aggcggggag agcagctttc cttccctgga gagaaccgtc   1447

 tttacctcag ctcctagggc ctccagcccc ccagctccac cacggtgact tggtgaaggg   1507

 ggaccaatgc cagaagaaag gggctgtaga cccctattcc ccaccccatg gccacagggc   1567

 atctggcaat aagactagta tacattgacc tcccgttccc tgcatgaggg cggggagttc   1627

 cccctgctcc atcccccatt gcatggggga agggcataaa gaatcattta tatgcacgtg   1687

 gagactcctt tctcatctgg ggcttttctg gagggttggg agatgtgggg aggtttctct   1747

 gcacaggttg caaatcccaa atgcagcagt gggttctgag ttgtaggtgt gactcccact   1807

 tgctggtgaa taattcatgt tggctgctag gtggcagcac tccgaggtat ctaaagggta   1867

 gacctggacc tgccacctat gagttgtgtg atatagaaaa aaatctctta gctctggttt   1927

 tcctgtctac ttcatagggt tggaataagg ataaatgagg gacaggttgg atgccgttgc   1987

 agagaaaatc agcaatgaca taaagagatt tctagaatag ttgatggtcc atttatttca   2047

 aatagtagct ggtgtaacaa attctaaaat gtgtttttca tctggagttg cacagaatca   2107

 tggaattttg tgttgagtga cataataggt atggaaatat gaggggaaat agacattgca   2167

 aatgtgaagc atggtggtta tttgttaaga atgagaactc ctctgactct aaatatttgg   2227

 gcctgtgggc tggggaaggc tggagccatc tgccttgttc tggagatcat ctgggttcta   2287

 tcagtccttc tcaagtactg tgctcaccca gaaaagcagt gtgaagtgaa tttggactca   2347

 tttggagtga gatggaggga atccccccac tcagtgttat gagtctccaa ccccagttta   2407

 agctatttcc atggcagttt agggtcacag gtttgatccc ggtgtgccca gccagtggta   2467

 ttaatggatg gcattatgtt tggaggcagc agcatagagg actgttgttt atagagaaaa   2527

 gatttgggaa ggactgttta caatgtgggt cagcctgaag cctgggcact ttcttctgtg   2587

 accttggggt tgtgtattat atgaatgatg ctgtttttaa gtaaaccatt caacagcaat   2647

 taaataattc cttcattcac ggctaaaaaa aaaaaaa                            2684




      <210> 138
      <211> 1503
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(892)

      <400> 138
 agtttcgcgg ccagaggctt acaggtccag gtggagaggc cgggctggcc agggcttcgg     60

 cctccggcgt cgggaa    atg gcg gcg ggg ggc agg atg gag gac ggt tcc     109
                      Met Ala Ala Gly Gly Arg Met Glu Asp Gly Ser
                        1               5                  10

 ttg gat atc acc cag agt att gaa gac gac cca ctt ctg gat gcc cag      157
 Leu Asp Ile Thr Gln Ser Ile Glu Asp Asp Pro Leu Leu Asp Ala Gln
              15                  20                  25

 ctt ctc cca cac cac tca tta caa gct cac ttt aga ccc cga ttc cat      205
 Leu Leu Pro His His Ser Leu Gln Ala His Phe Arg Pro Arg Phe His
          30                  35                  40

 cct ctt cct aca gtc atc ata gtg aat ctt ctg tgg ttt att cat ctc      253
 Pro Leu Pro Thr Val Ile Ile Val Asn Leu Leu Trp Phe Ile His Leu
      45                  50                  55

 gtg ttt gtt gtt tta gca ttt tta aca ggt gtg ctt tgt tct tat cct      301
 Val Phe Val Val Leu Ala Phe Leu Thr Gly Val Leu Cys Ser Tyr Pro
  60                  65                  70                  75

 aat cca aat gag gac aag tgc cca gga aat tac aca aac cca ttg aaa      349
 Asn Pro Asn Glu Asp Lys Cys Pro Gly Asn Tyr Thr Asn Pro Leu Lys
                  80                  85                  90

 gtt cag acg gtt ata atc ctt ggg aaa gtt att ttg tgg att ctc cat      397
 Val Gln Thr Val Ile Ile Leu Gly Lys Val Ile Leu Trp Ile Leu His
              95                 100                 105

 tta ctc ctt gaa tgc tac atc cag tat cac cac agc aaa atc aga aac      445
 Leu Leu Leu Glu Cys Tyr Ile Gln Tyr His His Ser Lys Ile Arg Asn
         110                 115                 120

 cga ggc tat aac ttg atc tac cga tca aca agg cat ctc aag aga ctt      493
 Arg Gly Tyr Asn Leu Ile Tyr Arg Ser Thr Arg His Leu Lys Arg Leu
     125                 130                 135

 gcg ttg atg ata cag tcc tct ggc aac aca gtg ctt ctc ctc ata ctg      541
 Ala Leu Met Ile Gln Ser Ser Gly Asn Thr Val Leu Leu Leu Ile Leu
 140                 145                 150                 155

 tgc atg cag cac tcc ttc cca gag cct ggc aga ttg tat ctt gac ctc      589
 Cys Met Gln His Ser Phe Pro Glu Pro Gly Arg Leu Tyr Leu Asp Leu
                 160                 165                 170

 att ctg gcc atc ttg gca ctg gaa ctc atc tgt tcc ctg ata tgt ctc      637
 Ile Leu Ala Ile Leu Ala Leu Glu Leu Ile Cys Ser Leu Ile Cys Leu
             175                 180                 185

 ctc att tac aca gtg aaa atc cgg aga ttt aat aaa gct aaa cca gag      685
 Leu Ile Tyr Thr Val Lys Ile Arg Arg Phe Asn Lys Ala Lys Pro Glu
         190                 195                 200

 cct gat ata ctt gaa gaa gaa aaa atc tat gct tac ccc agc aat att      733
 Pro Asp Ile Leu Glu Glu Glu Lys Ile Tyr Ala Tyr Pro Ser Asn Ile
     205                 210                 215

 acc tcg gag act gga ttc aga act att tca agc cta gaa gaa att gtt      781
 Thr Ser Glu Thr Gly Phe Arg Thr Ile Ser Ser Leu Glu Glu Ile Val
 220                 225                 230                 235

 gaa aag caa gga gac acc att gaa tac ctg aag cga cac aat gcg ctg      829
 Glu Lys Gln Gly Asp Thr Ile Glu Tyr Leu Lys Arg His Asn Ala Leu
                 240                 245                 250

 ctg agt aag cga ttg ttg gct ctc act tcc tca gac ctg ggc tgt cag      877
 Leu Ser Lys Arg Leu Leu Ala Leu Thr Ser Ser Asp Leu Gly Cys Gln
             255                 260                 265

 cca agt aga acg tga gaggctcacg gtcatgacag caattgcaga ggaacccaga      932
 Pro Ser Arg Thr 
         270

 gtaattgaga ctgactgacc acctgacaag ctgccacggg gaactgcagc ttttgctgaa    992

 tagcatttta cagtgtttgt tggaaacctg aatttggttc tgacttctgt ggctgtttaa   1052

 aatatagggc ttgtgggtca cttgaaaagt acctgtagaa gcccggataa cttgagggga   1112

 atgtctgttt gtacttttgg aaattattta actgcttggt ttatcctagg atcagaggct   1172

 aaacaactcc atagtcaaca cttttccacc tgacattaga accctgtaat gatttcatta   1232

 tggatagggg aagtctaaca agacaatcga ttttaaacag ggttttaatc aaataagttc   1292

 ttcccacttt taagctgatg aaagaagtca ttatttcttg tgaatatttt ttcctggaga   1352

 gccttatcat gtattttata tgcttatgtg gtgttggatg acatcatgga ccatatagct   1412

 tttatagaga atttttctca ccataggact gaggtctcac caggtgatct actatgcaaa   1472

 ttcctacagt tttctattct taagaaataa g                                  1503




      <210> 139
      <211> 3788
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3333)

      <400> 139
  atg gta ttc ctc aag cgt ggc aca gtg cct gac tct gag aag atg ctc      48
  Met Val Phe Leu Lys Arg Gly Thr Val Pro Asp Ser Glu Lys Met Leu
    1               5                  10                  15

 acg ggg ttg cca gta gaa gcc aca ttg agg aac cct gga gaa acc aga       96
 Thr Gly Leu Pro Val Glu Ala Thr Leu Arg Asn Pro Gly Glu Thr Arg
              20                  25                  30

 gaa act gag gcc ttg aag gga gat cag agg tcc agc cct cac ttc cca      144
 Glu Thr Glu Ala Leu Lys Gly Asp Gln Arg Ser Ser Pro His Phe Pro
          35                  40                  45

 gga ctg cca gca ctg gcc cat gaa cag ggc aat aag ggt ctc cga ctg      192
 Gly Leu Pro Ala Leu Ala His Glu Gln Gly Asn Lys Gly Leu Arg Leu
      50                  55                  60

 tcc cag acg ggc tgg tgt ggg ctt ggg atc ctc ctg gtg acc tct ccc      240
 Ser Gln Thr Gly Trp Cys Gly Leu Gly Ile Leu Leu Val Thr Ser Pro
  65                  70                  75                  80

 gct aag gtc cct cag cca ctc tgc ccc aag atg ggc cgt ggg gct ggc      288
 Ala Lys Val Pro Gln Pro Leu Cys Pro Lys Met Gly Arg Gly Ala Gly
                  85                  90                  95

 cgt gag tac tca cct gcc gcc acc acg gca gag aat ggg ggc ggc aag      336
 Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala Glu Asn Gly Gly Gly Lys
             100                 105                 110

 aag aaa cag aag gag aag gaa ctg gat gag ctg aag aag gag gtg gca      384
 Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu Leu Lys Lys Glu Val Ala
         115                 120                 125

 atg gat gac cac aag ctg tcc ttg gat gag ctg ggc cgc aaa tac caa      432
 Met Asp Asp His Lys Leu Ser Leu Asp Glu Leu Gly Arg Lys Tyr Gln
     130                 135                 140

 gtg gac ctg tcc aag ggc ctc acc aac cag cgg gct cag gac gtt ctg      480
 Val Asp Leu Ser Lys Gly Leu Thr Asn Gln Arg Ala Gln Asp Val Leu
 145                 150                 155                 160

 gct cga gat ggg ccc aac gcc ctc aca cca cct ccc aca acc cct gag      528
 Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu
                 165                 170                 175

 tgg gtc aag ttc tgc cgt cag ctt ttc ggg ggg ttc tcc atc ctg ctg      576
 Trp Val Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu
             180                 185                 190

 tgg att ggg gct atc ctc tgc ttc ctg gcc tac ggc atc cag gct gcc      624
 Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Ala
         195                 200                 205

 atg gag gat gaa cca tcc aac gac aat cta tat ctg ggt gtg gtg ctg      672
 Met Glu Asp Glu Pro Ser Asn Asp Asn Leu Tyr Leu Gly Val Val Leu
     210                 215                 220

 gca gct gtg gtc att gtc act ggc tgc ttc tcc tac tac cag gag gcc      720
 Ala Ala Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala
 225                 230                 235                 240

 aag agc tcc aag atc atg gat tcc ttc aag aac atg gta cct cag caa      768
 Lys Ser Ser Lys Ile Met Asp Ser Phe Lys Asn Met Val Pro Gln Gln
                 245                 250                 255

 gcc ctt gtg atc cgg gag gga gag aag atg cag atc aac gca gag gaa      816
 Ala Leu Val Ile Arg Glu Gly Glu Lys Met Gln Ile Asn Ala Glu Glu
             260                 265                 270

 gtg gtg gtg gga gac ctg gtg gag gtg aag ggt gga gac cgc gtc cct      864
 Val Val Val Gly Asp Leu Val Glu Val Lys Gly Gly Asp Arg Val Pro
         275                 280                 285

 gct gac ctc cgg atc atc tct tct cat ggc tgt aag gtg gat aac tca      912
 Ala Asp Leu Arg Ile Ile Ser Ser His Gly Cys Lys Val Asp Asn Ser
     290                 295                 300

 tcc tta aca gga gag tcg gag ccc cag acc cgc tcc ccc gag ttc acc      960
 Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Glu Phe Thr
 305                 310                 315                 320

 cat gag aac ccc ctg gag acc cgc aat atc tgt ttc ttc tcc acc aac     1008
 His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe Ser Thr Asn
                 325                 330                 335

 tgt gtt gaa ggc act gcc agg ggc att gtg att gcc aca gga gac cgg     1056
 Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr Gly Asp Arg
             340                 345                 350

 acg gtg atg ggc cgc ata gct act ctc gcc tca ggc ctg gag gtt ggg     1104
 Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly
         355                 360                 365

 cgg aca ccc ata gca atg gag att gaa cac ttc atc cag ctg atc aca     1152
 Arg Thr Pro Ile Ala Met Glu Ile Glu His Phe Ile Gln Leu Ile Thr
     370                 375                 380

 ggg gtc gct gta ttc ctg ggg gtc tcc ttc ttc gtg ctc tcc ctc atc     1200
 Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Val Leu Ser Leu Ile
 385                 390                 395                 400

 ctg ggc tac agc tgg ctg gag gca gtc atc ttc ctc atc ggc atc ata     1248
 Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile
                 405                 410                 415

 gtg gcc aac gtg cct gag ggg ctt ctg gcc act gtc act gtg tgc ctg     1296
 Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu
             420                 425                 430

 acc ctg aca gcc aag cgc atg gca cgg aag aac tgc ctg gtg aag aac     1344
 Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn
         435                 440                 445

 ctg gag gcg gtg gag acg ctg ggc tcc acg tcc acc atc tgc tca gac     1392
 Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp
     450                 455                 460

 aag acg ggc acc ctc acc cag aac cgc atg acc gtc gcc cac atg tgg     1440
 Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp
 465                 470                 475                 480

 ttc gac aac caa atc cat gag gct gac acc acc gaa gat cag tct ggg     1488
 Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly
                 485                 490                 495

 gcc act ttt gac aaa cga tcc cct acg tgg acg gcc ctg tct cga att     1536
 Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp Thr Ala Leu Ser Arg Ile
             500                 505                 510

 gct ggt ctc tgc aac cgc gcc gtc ttc aag gca gga cag gag aac atc     1584
 Ala Gly Leu Cys Asn Arg Ala Val Phe Lys Ala Gly Gln Glu Asn Ile
         515                 520                 525

 tcc gtg tct aag cgg gac aca gct ggt gat gcc tct gag tca gct ctg     1632
 Ser Val Ser Lys Arg Asp Thr Ala Gly Asp Ala Ser Glu Ser Ala Leu
     530                 535                 540

 ctc aag tgc att gag ctc tcc tgt ggc tca gtg agg aaa atg aga gac     1680
 Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser Val Arg Lys Met Arg Asp
 545                 550                 555                 560

 aga aac ccc aag gtg gca gag att cct ttc aac tct acc aac aag tac     1728
 Arg Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr
                 565                 570                 575

 cag ctg tct atc cac gag cga gaa gac agc ccc cag agc cac gtg ctg     1776
 Gln Leu Ser Ile His Glu Arg Glu Asp Ser Pro Gln Ser His Val Leu
             580                 585                 590

 gtg atg aag ggg gcc cca gag cgc att ctg gac cgg tgc tcc acc atc     1824
 Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile
         595                 600                 605

 ctg gtg cag ggc aag gag atc ccg ctc gac aag gag atg caa gat gcc     1872
 Leu Val Gln Gly Lys Glu Ile Pro Leu Asp Lys Glu Met Gln Asp Ala
     610                 615                 620

 ttt caa aat gcc tac atg gag ctg ggg gga ctt ggg gag cgt gtg ctg     1920
 Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly Leu Gly Glu Arg Val Leu
 625                 630                 635                 640

 gga ttc tgt caa ctg aat ctg cca tct gga aag ttt cct cgg ggc ttc     1968
 Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly Lys Phe Pro Arg Gly Phe
                 645                 650                 655

 aaa ttc gac agc gga gag ctg aac ttt ccc acg gag aag ctt tgc ttt     2016
 Lys Phe Asp Ser Gly Glu Leu Asn Phe Pro Thr Glu Lys Leu Cys Phe
             660                 665                 670

 gtg ggg ctc atg tct atg att gac cct ccc cgg gct gct gtg cca gat     2064
 Val Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp
         675                 680                 685

 gct gtg ggc aag tgc cga agc gca ggc atc aag gtg atc atg gta acc     2112
 Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr
     690                 695                 700

 ggg gat cac cct atc aca gcc aag gcc att gcc aaa ggc gtg ggc atc     2160
 Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile
 705                 710                 715                 720

 ata tca gag ggt aac gag act gtg gag gac att gca gcc cgg ctc aac     2208
 Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn
                 725                 730                 735

 att ccc atg agt caa gtc aac ccc aga gaa gcc aag gca tgc gtg gtg     2256
 Ile Pro Met Ser Gln Val Asn Pro Arg Glu Ala Lys Ala Cys Val Val
             740                 745                 750

 cac ggc tct gac ctg aag gac atg aca tcg gag cag ctc gat gag atc     2304
 His Gly Ser Asp Leu Lys Asp Met Thr Ser Glu Gln Leu Asp Glu Ile
         755                 760                 765

 ctc aag aac cac aca gag atc gtc ttt gct cga acg tct ccc cag cag     2352
 Leu Lys Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln
     770                 775                 780

 aag ctc atc att gtg gag gga tgt cag agg cag gga gcc att gtg gcc     2400
 Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala
 785                 790                 795                 800

 gtg acg ggt gac ggg gtg aac gac tcc cct gca ttg aag aag gct gac     2448
 Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp
                 805                 810                 815

 att ggc att gcc atg ggc atc tct ggc tct gac gtc tct aag cag gca     2496
 Ile Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys Gln Ala
             820                 825                 830

 gcc gac atg atc ctg ctg gat gac aac ttt gcc tcc atc gtc acg ggg     2544
 Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly
         835                 840                 845

 gtg gag gag ggc cgc ctg atc ttt gac aac ttg aag aaa tcc atc gcc     2592
 Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala
     850                 855                 860

 tac acc ctg acc agc aac atc ccc gag atc acc ccc ttc ctg ctg ttc     2640
 Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe
 865                 870                 875                 880

 atc att gcc aac atc ccc cta cct ctg ggc act gtg acc atc ctt tgc     2688
 Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly Thr Val Thr Ile Leu Cys
                 885                 890                 895

 att gac ctg ggc aca gat atg gtc cct gcc atc tcc ttg gcc tat gag     2736
 Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu
             900                 905                 910

 gca gct gag agt gat atc atg aag cgg cag cca cga aac tcc cag acg     2784
 Ala Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Ser Gln Thr
         915                 920                 925

 gac aag ctg gtg aat gag agg ctc atc agc atg gcc tac gga cag atc     2832
 Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile
     930                 935                 940

 ggg atg atc cag gca ctg ggt ggc ttc ttc acc tac ttt gtg atc ctg     2880
 Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Thr Tyr Phe Val Ile Leu
 945                 950                 955                 960

 gca gag aac ggt ttc ctg cca tca cgg cta ctg gga atc cgc ctc gac     2928
 Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu Leu Gly Ile Arg Leu Asp
                 965                 970                 975

 tgg gat gac cgg acc atg aat gat ctg gag gac agc tat gga cag gag     2976
 Trp Asp Asp Arg Thr Met Asn Asp Leu Glu Asp Ser Tyr Gly Gln Glu
             980                 985                 990

 tgg acc tat gag cag cgg aag gtg gtg gag ttc acg tgc cac acg gca     3024
 Trp Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala
         995                1000                1005

 ttc ttt gcc agc atc gtg gtg gtg cag tgg gct gac ctc atc atc tgc     3072
 Phe Phe Ala Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys
    1010                1015                1020

 aag acc cgc cgc aac tca gtc ttc cag cag ggc atg aag aac aag atc     3120
 Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile
1025                1030                1035                1040

 ctg att ttt ggg ctc ctg gag gag acg gcg ttg gct gcc ttt ctc tct     3168
 Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser
                1045                1050                1055

 tac tgc cca ggc atg ggt gta gcc ctc cgc atg tac ccg ctc aaa gtc     3216
 Tyr Cys Pro Gly Met Gly Val Ala Leu Arg Met Tyr Pro Leu Lys Val
            1060                1065                1070

 acc tgg tgg ttc tgc gcc ttc ccc tac agc ctc ctc atc ttc atc tat     3264
 Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser Leu Leu Ile Phe Ile Tyr
        1075                1080                1085

 gat gag gtc cga aag ctc atc ctg cgg cgg tat cct ggt ggc tgg gtg     3312
 Asp Glu Val Arg Lys Leu Ile Leu Arg Arg Tyr Pro Gly Gly Trp Val
    1090                1095                1100

 gag aag gag aca tac tac tga cc ccattggaag aagaaccagg catggaaaga     3365
 Glu Lys Glu Thr Tyr Tyr 
1105                1110

 tggggagctc tggaggtgtt gtggggatgg tgatggagag ggatggaaat aacgggtggc   3425

 attgggtggc aacatttggg gagagataat gaggcaactc agcaggctaa gttgcggggt   3485

 atataaattg gggtgatgac cccatagacc taactgtgaa caatcagatt agacactatg   3545

 tgttagagtc cccccgacca gatccttttc catcccactc cacatatgta gtctattttt   3605

 tctgaggaat taagggttac cccaccacat gacacaatcc catccccttc aagccctagt   3665

 taaatactga taatagatca gacatcacaa aagacaggaa cgcacatcta aacagaaagg   3725

 aagccctcat cagattcaga cactagcatt cacatacaat tacacaaatt ataaaaacca   3785

 cgc                                                                 3788




      <210> 140
      <211> 779
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(736)

      <400> 140
 gtccaacaat ccggacacgg cgggtctggg g   atg ggc cca gga atc cgc ctt      52
                                      Met Gly Pro Gly Ile Arg Leu
                                        1               5

 ttt agc agc att ccc cca aac gac acg gca gct tcg caa agc ggc ggt      100
 Phe Ser Ser Ile Pro Pro Asn Asp Thr Ala Ala Ser Gln Ser Gly Gly
          10                  15                  20

 ggc gtc tgc ggt tcc ggg cgc ggg cgg cct ccg gcc ggg gag ggc gct      148
 Gly Val Cys Gly Ser Gly Arg Gly Arg Pro Pro Ala Gly Glu Gly Ala
      25                  30                  35

 gtg cgg gcg gcg ctg ggg gcg ggc cgg ggg cgg agc gcg ggg cgc cgg      196
 Val Arg Ala Ala Leu Gly Ala Gly Arg Gly Arg Ser Ala Gly Arg Arg
  40                  45                  50                  55

 ctg ctc tgg cgg ctc ccg cgg ctc cgg ctg gcg gct tcg ggc cct gca      244
 Leu Leu Trp Arg Leu Pro Arg Leu Arg Leu Ala Ala Ser Gly Pro Ala
                  60                  65                  70

 cct gtg act ctc ggc cgc gct cgc cct cgg ccc gcc cgg cgc cgc agc      292
 Pro Val Thr Leu Gly Arg Ala Arg Pro Arg Pro Ala Arg Arg Arg Ser
              75                  80                  85

 ccc atg gcc ccg tcc agg ctg cag ctc ggc ctc cgc gcc gcc tac tcc      340
 Pro Met Ala Pro Ser Arg Leu Gln Leu Gly Leu Arg Ala Ala Tyr Ser
          90                  95                 100

 ggc atc agc tcc gtg gcc ggc ttc tcc atc ttc ctc gtc tgg acg gtg      388
 Gly Ile Ser Ser Val Ala Gly Phe Ser Ile Phe Leu Val Trp Thr Val
     105                 110                 115

 gtc tac cga cag ccg ggg acc gcg gcc atg gga ggg ctc gca ggg gtg      436
 Val Tyr Arg Gln Pro Gly Thr Ala Ala Met Gly Gly Leu Ala Gly Val
 120                 125                 130                 135

 ctg gca ctg tgg gtc ctg gtg acg cac gtg atg tac atg caa gat tat      484
 Leu Ala Leu Trp Val Leu Val Thr His Val Met Tyr Met Gln Asp Tyr
                 140                 145                 150

 tgg agg acc tgg ctc aag ggg ctg cgc ggc ttc ttc ttc gtg ggc gtc      532
 Trp Arg Thr Trp Leu Lys Gly Leu Arg Gly Phe Phe Phe Val Gly Val
             155                 160                 165

 ctc ttc tcg gcc gtc tcc atc gct gcc ttc tgc acc ttc ctc gtg ctg      580
 Leu Phe Ser Ala Val Ser Ile Ala Ala Phe Cys Thr Phe Leu Val Leu
         170                 175                 180

 gcc atc acc cgg cat cag agc ctc aca gac ccc acc agc tac tac ctc      628
 Ala Ile Thr Arg His Gln Ser Leu Thr Asp Pro Thr Ser Tyr Tyr Leu
     185                 190                 195

 tcc agc gtc tgg agc ttc att tcc ttc aag tgg gcc ttc ctg ctc agc      676
 Ser Ser Val Trp Ser Phe Ile Ser Phe Lys Trp Ala Phe Leu Leu Ser
 200                 205                 210                 215

 ctc tat gcc cac cgc tac cgg gct gac ttt gct gac atc agc atc ctc      724
 Leu Tyr Ala His Arg Tyr Arg Ala Asp Phe Ala Asp Ile Ser Ile Leu
                 220                 225                 230

 agc gat ttc tga ccc agggggtgag gtctctgcac cctggggggg ccttaggacc      779
 Ser Asp Phe 






      <210> 141
      <211> 1404
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(1404)

      <400> 141
 atgctgtcca ttgtatcttt tttcaaaatt cttaagtatc agaatttggt taaattatgt     60

 gacacccagt ttgtatccac tggagaattg gttgctggtg tggtgaaata cctacacatt    120

 ttggtgacca gaggtacatt tagagaagaa cagaaatgta cataccaatt tctg  atg     177
                                                              Met
                                                                1

 caa gga ttc atc tgc aaa cag act gac caa gtg gtc cta att ctt gat      225
 Gln Gly Phe Ile Cys Lys Gln Thr Asp Gln Val Val Leu Ile Leu Asp
               5                  10                  15

 agc gct gat gcc att tgg gca att cag aag tta tat cca gtt gta tct      273
 Ser Ala Asp Ala Ile Trp Ala Ile Gln Lys Leu Tyr Pro Val Val Ser
          20                  25                  30

 gtg act agt ggt ttt gtt gat gtc ttt agc agt gta aat gcc aat att      321
 Val Thr Ser Gly Phe Val Asp Val Phe Ser Ser Val Asn Ala Asn Ile
      35                  40                  45

 ccc tgc tct act tct ggg tca gtg tct act ttc tat tct atc tta ccc      369
 Pro Cys Ser Thr Ser Gly Ser Val Ser Thr Phe Tyr Ser Ile Leu Pro
  50                  55                  60                  65

 atc agg caa atc acc aaa gtc tgc ttc atg gat caa act cct caa gtt      417
 Ile Arg Gln Ile Thr Lys Val Cys Phe Met Asp Gln Thr Pro Gln Val
                  70                  75                  80

 ttg cgc ttt ttt cta ttg ggg aac aaa agt acc tcc aag ctt ctc ttg      465
 Leu Arg Phe Phe Leu Leu Gly Asn Lys Ser Thr Ser Lys Leu Leu Leu
              85                  90                  95

 gct gta ttc tac cat gag ctc cag agc ccc cac gtc ttc tta ggg gaa      513
 Ala Val Phe Tyr His Glu Leu Gln Ser Pro His Val Phe Leu Gly Glu
         100                 105                 110

 agt ttt att cca ccc act ctg gtt cag tca gct tcc tta ttg ctg aat      561
 Ser Phe Ile Pro Pro Thr Leu Val Gln Ser Ala Ser Leu Leu Leu Asn
     115                 120                 125

 gaa tct att ggt gcc aac tat ttc aac atc atg gat aac ctc ttg tat      609
 Glu Ser Ile Gly Ala Asn Tyr Phe Asn Ile Met Asp Asn Leu Leu Tyr
 130                 135                 140                 145

 gtt gtc cta caa gga gag gag ccc att gaa ata cgc tca ggt gtt tcc      657
 Val Val Leu Gln Gly Glu Glu Pro Ile Glu Ile Arg Ser Gly Val Ser
                 150                 155                 160

 att cac ttg gcc ctc act gtg atg gtt tca gtc tta gaa aaa ggc tgg      705
 Ile His Leu Ala Leu Thr Val Met Val Ser Val Leu Glu Lys Gly Trp
             165                 170                 175

 gaa ata gta ata ctc gaa aga cta act aac ttc tta cag att ggc caa      753
 Glu Ile Val Ile Leu Glu Arg Leu Thr Asn Phe Leu Gln Ile Gly Gln
         180                 185                 190

 aac caa atc agg ttt att cac gag atg cct ggc cat gaa gag acc tta      801
 Asn Gln Ile Arg Phe Ile His Glu Met Pro Gly His Glu Glu Thr Leu
     195                 200                 205

 aag gcc att gct gac agt aga gca aaa aga aag cgc aat tgc cct act      849
 Lys Ala Ile Ala Asp Ser Arg Ala Lys Arg Lys Arg Asn Cys Pro Thr
 210                 215                 220                 225

 gtg act tgc act agt cat tat aga aga gtt ggt caa cgt agg cct ctc      897
 Val Thr Cys Thr Ser His Tyr Arg Arg Val Gly Gln Arg Arg Pro Leu
                 230                 235                 240

 atg atg gaa atg aac tca cat agg gct tca ccc cca atg act gtg gaa      945
 Met Met Glu Met Asn Ser His Arg Ala Ser Pro Pro Met Thr Val Glu
             245                 250                 255

 act atc tca aaa gtg att gtc att gaa att ggt gat tcg cca aca gta      993
 Thr Ile Ser Lys Val Ile Val Ile Glu Ile Gly Asp Ser Pro Thr Val
         260                 265                 270

 agg agc act gga atg att tca tcc tta tca agt aac aaa tta cag aat     1041
 Arg Ser Thr Gly Met Ile Ser Ser Leu Ser Ser Asn Lys Leu Gln Asn
     275                 280                 285

 ttg gct cat cga gtc atc act gct caa cag act ggg gta cta gag aat     1089
 Leu Ala His Arg Val Ile Thr Ala Gln Gln Thr Gly Val Leu Glu Asn
 290                 295                 300                 305

 gtt ctg aat atg act atc ggg gcc tta cta gtt act cag tca aag gga     1137
 Val Leu Asn Met Thr Ile Gly Ala Leu Leu Val Thr Gln Ser Lys Gly
                 310                 315                 320

 gtc att ggc tat gga aat aca agc agt ttt aaa act ggg aac ttg ata     1185
 Val Ile Gly Tyr Gly Asn Thr Ser Ser Phe Lys Thr Gly Asn Leu Ile
             325                 330                 335

 tat att cgg ccc tat gca ctt tcc atc cta gtc cag cct tca gat gga     1233
 Tyr Ile Arg Pro Tyr Ala Leu Ser Ile Leu Val Gln Pro Ser Asp Gly
         340                 345                 350

 gaa gtg gga aat gag ctt cca gtg cag cca caa ttg gta ttt ttg gat     1281
 Glu Val Gly Asn Glu Leu Pro Val Gln Pro Gln Leu Val Phe Leu Asp
     355                 360                 365

 gag cag tat cat gga ctg ggc cag gga gca att tac caa gta caa tat     1329
 Glu Gln Tyr His Gly Leu Gly Gln Gly Ala Ile Tyr Gln Val Gln Tyr
 370                 375                 380                 385

 gat ttc tat ggg gaa ata gaa aga ctt gct ctc agt ggt atg aag aat     1377
 Asp Phe Tyr Gly Glu Ile Glu Arg Leu Ala Leu Ser Gly Met Lys Asn
                 390                 395                 400

 aaa tgt gat gac ctt atc cat acc taa                                 1404
 Lys Cys Asp Asp Leu Ile His Thr 
             405





      <210> 142
      <211> 3095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(2865)

      <400> 142
 ctggttctga gattctgtgc aagcctc    atg gaa atg aag ctg cca ggc cag      51
                                  Met Glu Met Lys Leu Pro Gly Gln
                                    1               5

 gaa ggg ttt gaa gcc tcc agt gct cct aga aat att cct tca ggg gag       99
 Glu Gly Phe Glu Ala Ser Ser Ala Pro Arg Asn Ile Pro Ser Gly Glu
      10                  15                  20

 ctg gac agc aac cct gac cct ggc acc ggc ccc agc cct gat ggc ccc      147
 Leu Asp Ser Asn Pro Asp Pro Gly Thr Gly Pro Ser Pro Asp Gly Pro
  25                  30                  35                  40

 tca gac aca gag agc aag gaa ctg gga gta ccc aaa gac cct ctg ctc      195
 Ser Asp Thr Glu Ser Lys Glu Leu Gly Val Pro Lys Asp Pro Leu Leu
                  45                  50                  55

 ttc att cag ctg aat gag ctg ctg ggc tgg ccc cag gcg ctg gag tgg      243
 Phe Ile Gln Leu Asn Glu Leu Leu Gly Trp Pro Gln Ala Leu Glu Trp
              60                  65                  70

 aga gag aca ggc agg tgg gta ctg ttt gag gag aag ttg gag gtg gct      291
 Arg Glu Thr Gly Arg Trp Val Leu Phe Glu Glu Lys Leu Glu Val Ala
          75                  80                  85

 gca ggc cgg tgg agt gcc ccc cac gtg ccc acc ctg gca ctg ccc agc      339
 Ala Gly Arg Trp Ser Ala Pro His Val Pro Thr Leu Ala Leu Pro Ser
      90                  95                 100

 ctc cag aag ctc cgc agc ctg ctg gcc gag ggc ctt gta ctg ctg gac      387
 Leu Gln Lys Leu Arg Ser Leu Leu Ala Glu Gly Leu Val Leu Leu Asp
 105                 110                 115                 120

 tgc cca gct cag agc ctc ctg gag ctc gtg gag cag gtg acc agg gtg      435
 Cys Pro Ala Gln Ser Leu Leu Glu Leu Val Glu Gln Val Thr Arg Val
                 125                 130                 135

 gag tcg ctg agc cca gag ctg aga ggg cag ttg cag gcc ttg ctg ctg      483
 Glu Ser Leu Ser Pro Glu Leu Arg Gly Gln Leu Gln Ala Leu Leu Leu
             140                 145                 150

 cag aga ccc cag cat tac aac cag acc aca ggc acc agg ccc tgc tgg      531
 Gln Arg Pro Gln His Tyr Asn Gln Thr Thr Gly Thr Arg Pro Cys Trp
         155                 160                 165

 ggc tct act cat cca aga aag gct tct gac aat gag gaa gcc ccc ctg      579
 Gly Ser Thr His Pro Arg Lys Ala Ser Asp Asn Glu Glu Ala Pro Leu
     170                 175                 180

 agg gaa cag tgt cag aac ccc ctg aga cag aag cta cct cca gga gct      627
 Arg Glu Gln Cys Gln Asn Pro Leu Arg Gln Lys Leu Pro Pro Gly Ala
 185                 190                 195                 200

 gag gca ggg act gtg ctg gca ggg gag ctg ggc ttc ctg gca cag cca      675
 Glu Ala Gly Thr Val Leu Ala Gly Glu Leu Gly Phe Leu Ala Gln Pro
                 205                 210                 215

 ctg gga gcc ttt gtt cga ctg cgg aac cct gtg gta ctg ggg tcc ctt      723
 Leu Gly Ala Phe Val Arg Leu Arg Asn Pro Val Val Leu Gly Ser Leu
             220                 225                 230

 act gag gtg tcc ctc cca agc agg ttt ttc tgc ctt ctc ctg ggc ccc      771
 Thr Glu Val Ser Leu Pro Ser Arg Phe Phe Cys Leu Leu Leu Gly Pro
         235                 240                 245

 tgt atg ctg gga aag ggc tac cat gag atg gga cgg gca gca gct gtc      819
 Cys Met Leu Gly Lys Gly Tyr His Glu Met Gly Arg Ala Ala Ala Val
     250                 255                 260

 ctc ctc agt gac ccg caa ttc cag tgg tca gtt cgt cgg gcc agc aac      867
 Leu Leu Ser Asp Pro Gln Phe Gln Trp Ser Val Arg Arg Ala Ser Asn
 265                 270                 275                 280

 ctt cat gac ctt ctg gca gcc ctg gat gca ttc cta gag gag gtg aca      915
 Leu His Asp Leu Leu Ala Ala Leu Asp Ala Phe Leu Glu Glu Val Thr
                 285                 290                 295

 gtg ctt ccc cca ggt cgg tgg gac cca aca gcc cgg att ccc ccg ccc      963
 Val Leu Pro Pro Gly Arg Trp Asp Pro Thr Ala Arg Ile Pro Pro Pro
             300                 305                 310

 aaa tgt ctg cca tct cag cac aaa agg ctt ccc tcg caa cag cgg gag     1011
 Lys Cys Leu Pro Ser Gln His Lys Arg Leu Pro Ser Gln Gln Arg Glu
         315                 320                 325

 atc aga ggt ccc gcc gtc ccg cgc ctg acc tcg gct gag gac agg cac     1059
 Ile Arg Gly Pro Ala Val Pro Arg Leu Thr Ser Ala Glu Asp Arg His
     330                 335                 340

 cgc cat ggg cca cac gca cac agc ccg gag ttg cag cgg acc ggc agg     1107
 Arg His Gly Pro His Ala His Ser Pro Glu Leu Gln Arg Thr Gly Arg
 345                 350                 355                 360

 aag gtc ccg tgg tac ccc agc gat ttc ttg gac gcc ctg cat ctc cag     1155
 Lys Val Pro Trp Tyr Pro Ser Asp Phe Leu Asp Ala Leu His Leu Gln
                 365                 370                 375

 tgc ttc tcg gcc gta ctc tac att tac ctg gcc act gtc act aat gcc     1203
 Cys Phe Ser Ala Val Leu Tyr Ile Tyr Leu Ala Thr Val Thr Asn Ala
             380                 385                 390

 atc act ttt ggg ggt ctg ctg gga gat gcc act gat ggt gcc cag gga     1251
 Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp Gly Ala Gln Gly
         395                 400                 405

 gtg ctg gaa agt ttc ctg ggc aca gca atg gct gga gct gcc ttc tgc     1299
 Val Leu Glu Ser Phe Leu Gly Thr Ala Met Ala Gly Ala Ala Phe Cys
     410                 415                 420

 ctg atg gca ggc cag ccc ctc acc att ctg agc agc acg ggg cca gtg     1347
 Leu Met Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser Thr Gly Pro Val
 425                 430                 435                 440

 ctg gtc ttt gag cgc ctg ctc ttc tct ttc agc aga gat tac agc ctg     1395
 Leu Val Phe Glu Arg Leu Leu Phe Ser Phe Ser Arg Asp Tyr Ser Leu
                 445                 450                 455

 gac tac ctg ccc ttc cgc cta tgg gtg ggc atc tgg gtg gct acc ttt     1443
 Asp Tyr Leu Pro Phe Arg Leu Trp Val Gly Ile Trp Val Ala Thr Phe
             460                 465                 470

 tgc ctg gtg ctg gtg gcc aca gag gcc agt gtg ctg gtg cgc tac ttc     1491
 Cys Leu Val Leu Val Ala Thr Glu Ala Ser Val Leu Val Arg Tyr Phe
         475                 480                 485

 acc cgc ttc act gag gaa ggt ttc tgt gcc ctc atc agc ctc atc ttc     1539
 Thr Arg Phe Thr Glu Glu Gly Phe Cys Ala Leu Ile Ser Leu Ile Phe
     490                 495                 500

 atc tac gat gct gtg ggc aaa atg ctg aac ttg acc cat acc tat cct     1587
 Ile Tyr Asp Ala Val Gly Lys Met Leu Asn Leu Thr His Thr Tyr Pro
 505                 510                 515                 520

 atc cag aag cct ggg tcc tct gcc tac ggg tgc ctc tgc caa tac cca     1635
 Ile Gln Lys Pro Gly Ser Ser Ala Tyr Gly Cys Leu Cys Gln Tyr Pro
                 525                 530                 535

 ggc cca gga gga aat gag tct caa tgg ata agg aca agg cca aaa gac     1683
 Gly Pro Gly Gly Asn Glu Ser Gln Trp Ile Arg Thr Arg Pro Lys Asp
             540                 545                 550

 aga gac gac atc gac tta ggc ctg atc aat gca tcc ttg ctg ccg cca     1731
 Arg Asp Asp Ile Asp Leu Gly Leu Ile Asn Ala Ser Leu Leu Pro Pro
         555                 560                 565

 cct gag tgc acc cgg cag gga ggc cac cct cgt ggc cct ggc tgt cat     1779
 Pro Glu Cys Thr Arg Gln Gly Gly His Pro Arg Gly Pro Gly Cys His
     570                 575                 580

 aca gtc cca gac att gcc ttc ttc tcc ctt ctc ctc ttc ctt act tct     1827
 Thr Val Pro Asp Ile Ala Phe Phe Ser Leu Leu Leu Phe Leu Thr Ser
 585                 590                 595                 600

 ttc ttc ttt gct atg gcc ctc aag tgt gta aag acc agc cgc ttc ttc     1875
 Phe Phe Phe Ala Met Ala Leu Lys Cys Val Lys Thr Ser Arg Phe Phe
                 605                 610                 615

 ccc tct gtg gtg cgc aaa ggg ctc agc gac ttc tcc tca gtc ctg gcc     1923
 Pro Ser Val Val Arg Lys Gly Leu Ser Asp Phe Ser Ser Val Leu Ala
             620                 625                 630

 atc ctg ctc ggc tgt ggc ctt gat gct ttc ctg ggc cta gcc aca cca     1971
 Ile Leu Leu Gly Cys Gly Leu Asp Ala Phe Leu Gly Leu Ala Thr Pro
         635                 640                 645

 aag ctc atg gta ccc aga gag ttc aag ccc aca ctc cct ggg cgt ggc     2019
 Lys Leu Met Val Pro Arg Glu Phe Lys Pro Thr Leu Pro Gly Arg Gly
     650                 655                 660

 tgg ctg gtg tca cct ttt gga gcc aac ccc tgg tgg tgg agt gtg gca     2067
 Trp Leu Val Ser Pro Phe Gly Ala Asn Pro Trp Trp Trp Ser Val Ala
 665                 670                 675                 680

 gct gcc ctg cct gcc ctg ctg ctg tct atc ctc atc ttc atg gac caa     2115
 Ala Ala Leu Pro Ala Leu Leu Leu Ser Ile Leu Ile Phe Met Asp Gln
                 685                 690                 695

 cag atc aca gca gtc atc ctc aac cgc atg gaa tac aga ctg cag aag     2163
 Gln Ile Thr Ala Val Ile Leu Asn Arg Met Glu Tyr Arg Leu Gln Lys
             700                 705                 710

 gga gct ggc ttc cac ctg gac ctc ttc tgt gtg gct gtg ctg atg cta     2211
 Gly Ala Gly Phe His Leu Asp Leu Phe Cys Val Ala Val Leu Met Leu
         715                 720                 725

 ctc aca tca gcg ctt gga ctg cct tgg tat gtc tca gcc act gtc atc     2259
 Leu Thr Ser Ala Leu Gly Leu Pro Trp Tyr Val Ser Ala Thr Val Ile
     730                 735                 740

 tcc ctg gct cac atg gac agt ctt cgg aga gag agc aaa gcc tgt gcc     2307
 Ser Leu Ala His Met Asp Ser Leu Arg Arg Glu Ser Lys Ala Cys Ala
 745                 750                 755                 760

 ccc ggg gag cgc ccc aac ttc ctg ggt atc agg gaa cag agg ctg aca     2355
 Pro Gly Glu Arg Pro Asn Phe Leu Gly Ile Arg Glu Gln Arg Leu Thr
                 765                 770                 775

 ggc ctg gtg gtg ttc atc ctt aca gga gcc tcc atc ttc ctg gca cct     2403
 Gly Leu Val Val Phe Ile Leu Thr Gly Ala Ser Ile Phe Leu Ala Pro
             780                 785                 790

 gtg ctc aag ttc att cca atg cct gtg ctc tat ggc atc ttc ctg tat     2451
 Val Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Ile Phe Leu Tyr
         795                 800                 805

 atg ggg gtg gca gcg ctc agc agc att cag ttc act aat agg gtg aag     2499
 Met Gly Val Ala Ala Leu Ser Ser Ile Gln Phe Thr Asn Arg Val Lys
     810                 815                 820

 ctg ttg ttg atg cca gca aaa cac cag cca gac ctg cta ctc ttg cgg     2547
 Leu Leu Leu Met Pro Ala Lys His Gln Pro Asp Leu Leu Leu Leu Arg
 825                 830                 835                 840

 cat gtg cct ctg acc agg gtc cac ctc ttc aca gcc atc cag ctt gcc     2595
 His Val Pro Leu Thr Arg Val His Leu Phe Thr Ala Ile Gln Leu Ala
                 845                 850                 855

 tgt ctg ggg ctg ctt tgg ata atc aag tct acc cct gca gcc atc atc     2643
 Cys Leu Gly Leu Leu Trp Ile Ile Lys Ser Thr Pro Ala Ala Ile Ile
             860                 865                 870

 ttc ccc ctc atg ttg ctg ggc ctt gtg ggg gtc cga aag gcc ctg gag     2691
 Phe Pro Leu Met Leu Leu Gly Leu Val Gly Val Arg Lys Ala Leu Glu
         875                 880                 885

 agg gtc ttc tca cca cag gaa ctc ctc tgg ctg gat gag ctg atg cca     2739
 Arg Val Phe Ser Pro Gln Glu Leu Leu Trp Leu Asp Glu Leu Met Pro
     890                 895                 900

 gag gag gag aga agc atc cct gag aag ggg ctg gag cca gaa cac tca     2787
 Glu Glu Glu Arg Ser Ile Pro Glu Lys Gly Leu Glu Pro Glu His Ser
 905                 910                 915                 920

 ttc agt gga agt gac agt gaa gat tca gag ctg atg tat cag cca aag     2835
 Phe Ser Gly Ser Asp Ser Glu Asp Ser Glu Leu Met Tyr Gln Pro Lys
                 925                 930                 935

 gct cca gaa atc aac att tct gtg aat tag c tggagtagga gtctgggagt     2886
 Ala Pro Glu Ile Asn Ile Ser Val Asn 
             940                 945

 ggagacccca ggaaacagca tgagatgctc agtcggcttg gggaaggact gaagggcagc   2946

 tgccaagacc tcagttacct cctgacctga gggtggagag tggcaggaag caagcatgtt   3006

 tgctgtgcac ttaggaaagg ctggtgagcc agagggactg atcaggcccc attcaccctc   3066

 tactcattaa aaggtcctga aaaaaaaaa                                     3095




      <210> 143
      <211> 1572
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (608)..(1438)

      <400> 143
 tggaatgtgt atgtggtaat ggtgtctgag cgatggaatg aagtgaaaga aatagccaag     60

 agctgggcac tgagggaaca agctgggggg ccctgggcgt gggttccctg gatccaggga    120

 gtgtgaggat ggctttctct ggttcctgag gcatggaccg agtcctagcc tgcatctgag    180

 ctccgttgtg ctagctttgt ggtgtctggg tcggggaagt tactgttaga aagttgccgt    240

 cagcgggcgt tgttccagct ttccatggaa attctgggag ctgctcctag tttgcggcgg    300

 agccttcctt ccttccctgc attgggcgct ggaccttcac ggccaggagg ctccaaggcc    360

 caggcttttc gccaacagca acaggctact ggctgggccc aggcaagggg gccttggcag    420

 gaaaagttcc ttgctgtacc tccactgcac tcagaggcca gtgagggggg taccagacag    480

 gactccttcc tccctggtga agtgcccttg cagctcccta gtgtccacgc catggatatt    540

 tcctccacag aagtacaatg ctgattatga tctgtcagct cggcaagggg cagacaccct    600

 ggccttc  atg tct ctc ctg gag gag aag ttg ctc ccg gtg ctg gtg agt     649
          Met Ser Leu Leu Glu Glu Lys Leu Leu Pro Val Leu Val Ser
            1               5                  10

 gtg ccc aga cct ccc agc atc cat ggc cag ccg ggg agg gtt cgg gaa      697
 Val Pro Arg Pro Pro Ser Ile His Gly Gln Pro Gly Arg Val Arg Glu
  15                  20                  25                  30

 cac aca gac cca cac aca ggc tca gga aag cat ggg ggt cag aag ccc      745
 His Thr Asp Pro His Thr Gly Ser Gly Lys His Gly Gly Gln Lys Pro
                  35                  40                  45

 acc ttg aat cag aca ggt gca ctg gct cag acc tac ctg ttt ctt cct      793
 Thr Leu Asn Gln Thr Gly Ala Leu Ala Gln Thr Tyr Leu Phe Leu Pro
              50                  55                  60

 gcc cac cca atc cag gta cat act ttt tgg ata gac acc aag aac tac      841
 Ala His Pro Ile Gln Val His Thr Phe Trp Ile Asp Thr Lys Asn Tyr
          65                  70                  75

 gtg gaa gtg acc cgg aag tgg tat gca gag gct atg ccc ttt ccc ctc      889
 Val Glu Val Thr Arg Lys Trp Tyr Ala Glu Ala Met Pro Phe Pro Leu
      80                  85                  90

 aac ttc ttc ctg cct ggc cgc atg cag cgg cag tac atg gaa cgg cta      937
 Asn Phe Phe Leu Pro Gly Arg Met Gln Arg Gln Tyr Met Glu Arg Leu
  95                 100                 105                 110

 cag ctg ctg act ggg gag cac agg cct gag gac gag gaa gag ctg gag      985
 Gln Leu Leu Thr Gly Glu His Arg Pro Glu Asp Glu Glu Glu Leu Glu
                 115                 120                 125

 aag gag ctg tac cga gag gct cgg gag tgt ctg acc ctg ctc tct cag     1033
 Lys Glu Leu Tyr Arg Glu Ala Arg Glu Cys Leu Thr Leu Leu Ser Gln
             130                 135                 140

 cgc ctg ggc tct caa aag ttc ttc ttt gga gat gcc cct gcc tcc ttg     1081
 Arg Leu Gly Ser Gln Lys Phe Phe Phe Gly Asp Ala Pro Ala Ser Leu
         145                 150                 155

 gac gcc ttc gtc ttc agc tac ttg gcc ctg ctg ctg cag gca aag ctg     1129
 Asp Ala Phe Val Phe Ser Tyr Leu Ala Leu Leu Leu Gln Ala Lys Leu
     160                 165                 170

 ccc agt ggg aag ctg cag gtc cac ctg cgt ggg ctg cac aac ctc tgt     1177
 Pro Ser Gly Lys Leu Gln Val His Leu Arg Gly Leu His Asn Leu Cys
 175                 180                 185                 190

 gcc tat tgt acc cac att ctc agt ctc tac ttc ccc tgg gat gga gct     1225
 Ala Tyr Cys Thr His Ile Leu Ser Leu Tyr Phe Pro Trp Asp Gly Ala
                 195                 200                 205

 gag gta cca ccg caa cgc cag aca cca gca ggc cca gag act gag gag     1273
 Glu Val Pro Pro Gln Arg Gln Thr Pro Ala Gly Pro Glu Thr Glu Glu
             210                 215                 220

 gag cca tac cgg cgc cgg aac cag atc cta tct gtg ctg gca gga ctg     1321
 Glu Pro Tyr Arg Arg Arg Asn Gln Ile Leu Ser Val Leu Ala Gly Leu
         225                 230                 235

 gca gcc atg gtg ggc tac gcc ttg ctc agc ggc att gtc tcc atc cag     1369
 Ala Ala Met Val Gly Tyr Ala Leu Leu Ser Gly Ile Val Ser Ile Gln
     240                 245                 250

 cgg gca acg cct gct cgg gcc cca ggc acc cgg acc ctg ggc atg gct     1417
 Arg Ala Thr Pro Ala Arg Ala Pro Gly Thr Arg Thr Leu Gly Met Ala
 255                 260                 265                 270

 gag gag gat gaa gag gaa tga tt tgtcctcacg ctcccaagac tggtttttct     1470
 Glu Glu Asp Glu Glu Glu 
                 275

 actctcatgc attccagagg cccccgtgcc tcctcgttgt tggtacagcc ggacacgcgg   1530

 tgctgccacc cagaataaag cccctcaccc tgaaaaaaaa aa                      1572




      <210> 144
      <211> 1387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(1253)

      <400> 144
 caggcgttcg gggctccact tggacgaggc gccgtgacac tccgaggcgc gccgggccga     60

 cagcgctgtc ccgctacgtg ggccacctct gg  atg ggc cgg cgg ccg ccc tcc     113
                                      Met Gly Arg Arg Pro Pro Ser
                                        1               5

 ccc gag gcc cgc ggc cca gtc ccc cgc agt tca gct gcc agt cgg gcc      161
 Pro Glu Ala Arg Gly Pro Val Pro Arg Ser Ser Ala Ala Ser Arg Ala
          10                  15                  20

 aga aga agc ctc gcc tcc ccg ggg atc tcc cca ggc ccc ctg acc gca      209
 Arg Arg Ser Leu Ala Ser Pro Gly Ile Ser Pro Gly Pro Leu Thr Ala
      25                  30                  35

 acg atc gga ggg gcg gtg gcg ggg ggc ggg ccc agg cag ggg agg gca      257
 Thr Ile Gly Gly Ala Val Ala Gly Gly Gly Pro Arg Gln Gly Arg Ala
  40                  45                  50                  55

 gaa gca cac aag gaa gtg ttt ccg gga cag agg gtg ggc aag atg gcg      305
 Glu Ala His Lys Glu Val Phe Pro Gly Gln Arg Val Gly Lys Met Ala
                  60                  65                  70

 gcg ccc atg gag ctg ttc tgc tgg tca ggg ggc tgg ggg ctg ccg tca      353
 Ala Pro Met Glu Leu Phe Cys Trp Ser Gly Gly Trp Gly Leu Pro Ser
              75                  80                  85

 gtg gac ctg gac agc ctg gcc gtg ctg acc tat gcc aga ttt act ggt      401
 Val Asp Leu Asp Ser Leu Ala Val Leu Thr Tyr Ala Arg Phe Thr Gly
          90                  95                 100

 gct cca ctg aag gta cac aag atc agc aac ccc tgg cag agc cct tca      449
 Ala Pro Leu Lys Val His Lys Ile Ser Asn Pro Trp Gln Ser Pro Ser
     105                 110                 115

 gga act ctg cct gcc ctt cgg acc agt cat gga gag gtc atc tca gtt      497
 Gly Thr Leu Pro Ala Leu Arg Thr Ser His Gly Glu Val Ile Ser Val
 120                 125                 130                 135

 cca cac aag atc atc acc cac ctt cga aaa gag aag tac aat gct gat      545
 Pro His Lys Ile Ile Thr His Leu Arg Lys Glu Lys Tyr Asn Ala Asp
                 140                 145                 150

 tat gat ctg tca gct cgg caa ggg gca gac acc ctg gcc ttc atg tct      593
 Tyr Asp Leu Ser Ala Arg Gln Gly Ala Asp Thr Leu Ala Phe Met Ser
             155                 160                 165

 ctc ctg gaa gag aag ttg ctc ccg gtg ctg gta cat act ttt tgg ata      641
 Leu Leu Glu Glu Lys Leu Leu Pro Val Leu Val His Thr Phe Trp Ile
         170                 175                 180

 gac acc aag aac tac gtg gaa gtg acc cgg aag tgg tat gca gag gct      689
 Asp Thr Lys Asn Tyr Val Glu Val Thr Arg Lys Trp Tyr Ala Glu Ala
     185                 190                 195

 atg ccc ttt ccc ctc aac ttc ttc ctg cct ggc cgc atg cag cgg cag      737
 Met Pro Phe Pro Leu Asn Phe Phe Leu Pro Gly Arg Met Gln Arg Gln
 200                 205                 210                 215

 tac atg gaa cgg cta cag ctg ctg act ggg gag cac agg cct gag gac      785
 Tyr Met Glu Arg Leu Gln Leu Leu Thr Gly Glu His Arg Pro Glu Asp
                 220                 225                 230

 gag gaa gag ctg gag aag gag ctg tac cga gag gct cgg gag tgt ctg      833
 Glu Glu Glu Leu Glu Lys Glu Leu Tyr Arg Glu Ala Arg Glu Cys Leu
             235                 240                 245

 acc ctg ctc tct cag cgc ctg ggc tct caa aag ttc ttc ttt gga gat      881
 Thr Leu Leu Ser Gln Arg Leu Gly Ser Gln Lys Phe Phe Phe Gly Asp
         250                 255                 260

 gcc cct gcc tcc ttg gac gcc ttc gtc ttc agc tac ttg gcc ctg ctg      929
 Ala Pro Ala Ser Leu Asp Ala Phe Val Phe Ser Tyr Leu Ala Leu Leu
     265                 270                 275

 ctg cag gca aag ctg ccc agt ggg aag ctg cag gtc cac ctg cgt ggg      977
 Leu Gln Ala Lys Leu Pro Ser Gly Lys Leu Gln Val His Leu Arg Gly
 280                 285                 290                 295

 ctg cac aac ctc tgt gcc tat tgt acc cac att ctc agt ctc tac ttc     1025
 Leu His Asn Leu Cys Ala Tyr Cys Thr His Ile Leu Ser Leu Tyr Phe
                 300                 305                 310

 ccc tgg gat gga gct gag gta cca ccg caa cgc cag aca cca gca ggc     1073
 Pro Trp Asp Gly Ala Glu Val Pro Pro Gln Arg Gln Thr Pro Ala Gly
             315                 320                 325

 cca gag act gag gag gag cca tac cgg cgc cgg aac cag atc cta tct     1121
 Pro Glu Thr Glu Glu Glu Pro Tyr Arg Arg Arg Asn Gln Ile Leu Ser
         330                 335                 340

 gtg ctg gca gga ctg gca gcc atg gtg ggc tac gcc ttg ctc agc ggc     1169
 Val Leu Ala Gly Leu Ala Ala Met Val Gly Tyr Ala Leu Leu Ser Gly
     345                 350                 355

 att gtc tcc atc cag cgg gca acg cct gct cgg gcc cca ggc acc cgg     1217
 Ile Val Ser Ile Gln Arg Ala Thr Pro Ala Arg Ala Pro Gly Thr Arg
 360                 365                 370                 375

 acc ctg ggc atg gct gag gag gat gaa gag gaa tga tttg tcctcacgct     1267
 Thr Leu Gly Met Ala Glu Glu Asp Glu Glu Glu 
                 380                 385

 cccaagactg gtttttctac tctcatgcat tccagaggcc cccgtgcctc ctcgttgttg   1327

 gtacagccgg acacggggtg ctgccaccca gaataaagcc actcacactg aaaaaaaaaa   1387




      <210> 145
      <211> 1865
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(1815)

      <400> 145
 atggcagggg acgtggaagg attctgttcc tccatccacg acaccagtgt ctctgctggg     60

 ttcagagcac tgtatgagga gggattgctt cttgatgtca ctctggttat tgaagatcat    120

 cagttccagg cccataaagc actcttggcc acccagagtg attacttcag aatt  atg     177
                                                              Met
                                                                1

 ttt act gca gac atg agg gaa cga gat cag gac aaa att cat tta aaa      225
 Phe Thr Ala Asp Met Arg Glu Arg Asp Gln Asp Lys Ile His Leu Lys
               5                  10                  15

 ggt cta aca gct acc ggt ttc agc cat gtc ctg caa ttt atg tac tat      273
 Gly Leu Thr Ala Thr Gly Phe Ser His Val Leu Gln Phe Met Tyr Tyr
          20                  25                  30

 gga act ata gag ctg agt atg aat acc gtt cat gag att ctt cag gct      321
 Gly Thr Ile Glu Leu Ser Met Asn Thr Val His Glu Ile Leu Gln Ala
      35                  40                  45

 gcc atg tat gtt caa ctt ata gaa gtg gtg aag ttc tgc tgc tct ttt      369
 Ala Met Tyr Val Gln Leu Ile Glu Val Val Lys Phe Cys Cys Ser Phe
  50                  55                  60                  65

 ctc tta gcg aag atc tgc cta gaa aat tgt gca gaa att atg aga ctc      417
 Leu Leu Ala Lys Ile Cys Leu Glu Asn Cys Ala Glu Ile Met Arg Leu
                  70                  75                  80

 tta gat gat ttc ggc gta aac atc gag gga gtc agg gag aag tta gac      465
 Leu Asp Asp Phe Gly Val Asn Ile Glu Gly Val Arg Glu Lys Leu Asp
              85                  90                  95

 acc ttt ctg cta gac aac ttt gtg cca ctc atg tct agg cct gac ttt      513
 Thr Phe Leu Leu Asp Asn Phe Val Pro Leu Met Ser Arg Pro Asp Phe
         100                 105                 110

 ctg tcc tat ctg agc ttt gag aag ctc atg tct tac ttg gat aat gat      561
 Leu Ser Tyr Leu Ser Phe Glu Lys Leu Met Ser Tyr Leu Asp Asn Asp
     115                 120                 125

 cat ctg agc agg ttc cca gag ata gag ctg tac gag gct gtg cag tct      609
 His Leu Ser Arg Phe Pro Glu Ile Glu Leu Tyr Glu Ala Val Gln Ser
 130                 135                 140                 145

 tgg ctg cgg cat gat aga aga cgc tgg aga cat acc gat acc atc att      657
 Trp Leu Arg His Asp Arg Arg Arg Trp Arg His Thr Asp Thr Ile Ile
                 150                 155                 160

 cag aat atc cgg ttt tgc ttg atg acc cca acc agc gtt ttt gag aag      705
 Gln Asn Ile Arg Phe Cys Leu Met Thr Pro Thr Ser Val Phe Glu Lys
             165                 170                 175

 gtt aag aca tca gaa ttt tat aga tac tcc cga cag ctc cgt tac gaa      753
 Val Lys Thr Ser Glu Phe Tyr Arg Tyr Ser Arg Gln Leu Arg Tyr Glu
         180                 185                 190

 gtt gac caa gca ttg aat tac ttt cag aat gtt cac cag cag cct ttg      801
 Val Asp Gln Ala Leu Asn Tyr Phe Gln Asn Val His Gln Gln Pro Leu
     195                 200                 205

 ttg gat atg aag tca agc cgc atc cgt tct gca aaa ccg caa act aca      849
 Leu Asp Met Lys Ser Ser Arg Ile Arg Ser Ala Lys Pro Gln Thr Thr
 210                 215                 220                 225

 gta ttt cga gga atg att gga cat agc atg gtt aac agt aaa ata ctt      897
 Val Phe Arg Gly Met Ile Gly His Ser Met Val Asn Ser Lys Ile Leu
                 230                 235                 240

 ctc tta aag aaa cca aga gtc tgg tgg gag cta gaa ggc cca caa gta      945
 Leu Leu Lys Lys Pro Arg Val Trp Trp Glu Leu Glu Gly Pro Gln Val
             245                 250                 255

 cct ctg cga cct gac tgc ctt gct atc gtc aat aat ttt gtg ttc ctg      993
 Pro Leu Arg Pro Asp Cys Leu Ala Ile Val Asn Asn Phe Val Phe Leu
         260                 265                 270

 tta ggc ggg gaa gag ctg ggc ccg gat ggt gaa ttc cat gct tct tcc     1041
 Leu Gly Gly Glu Glu Leu Gly Pro Asp Gly Glu Phe His Ala Ser Ser
     275                 280                 285

 aaa gta ttc agg tat gac ccg aga cag aac tcc tgg ctg cag atg gca     1089
 Lys Val Phe Arg Tyr Asp Pro Arg Gln Asn Ser Trp Leu Gln Met Ala
 290                 295                 300                 305

 gat atg tct gta cca cgc tct gaa ttt gct gta ggt gtt att ggg aag     1137
 Asp Met Ser Val Pro Arg Ser Glu Phe Ala Val Gly Val Ile Gly Lys
                 310                 315                 320

 ttt att tac gcc gta gca ggc aga acc aga gat gag act ttc tat tca     1185
 Phe Ile Tyr Ala Val Ala Gly Arg Thr Arg Asp Glu Thr Phe Tyr Ser
             325                 330                 335

 act gag aga tat gac atc acc aac gat aaa tgg gaa ttt gtg gat cct     1233
 Thr Glu Arg Tyr Asp Ile Thr Asn Asp Lys Trp Glu Phe Val Asp Pro
         340                 345                 350

 tat cca gtt aac aaa tat gga cat gag ggg aca gtg ctc aat aac aaa     1281
 Tyr Pro Val Asn Lys Tyr Gly His Glu Gly Thr Val Leu Asn Asn Lys
     355                 360                 365

 ttg ttt atc acc ggt gga atc acc tca tct tcc acc tcc aag caa gtg     1329
 Leu Phe Ile Thr Gly Gly Ile Thr Ser Ser Ser Thr Ser Lys Gln Val
 370                 375                 380                 385

 tgc gtg ttt gac ccc agc aaa gaa ggg acc ata gaa caa cgg acc agg     1377
 Cys Val Phe Asp Pro Ser Lys Glu Gly Thr Ile Glu Gln Arg Thr Arg
                 390                 395                 400

 aga act caa gtg gtt acc aac tgt tgg gag aat aag agc aag atg aat     1425
 Arg Thr Gln Val Val Thr Asn Cys Trp Glu Asn Lys Ser Lys Met Asn
             405                 410                 415

 tac gcg aga tgc ttt cac aag atg att tct tac aat ggc aag ctt tat     1473
 Tyr Ala Arg Cys Phe His Lys Met Ile Ser Tyr Asn Gly Lys Leu Tyr
         420                 425                 430

 gtc ttc ggt ggt gtc tgt gtg atc ttg agg gcc tct ttc gaa tct cag     1521
 Val Phe Gly Gly Val Cys Val Ile Leu Arg Ala Ser Phe Glu Ser Gln
     435                 440                 445

 gga tgc cct tct aca gaa gta tac aac cca gag act gat cag tgg acc     1569
 Gly Cys Pro Ser Thr Glu Val Tyr Asn Pro Glu Thr Asp Gln Trp Thr
 450                 455                 460                 465

 atc ttg gca tcc atg ccg att ggt aga agt ggc cat ggt gtg act gtg     1617
 Ile Leu Ala Ser Met Pro Ile Gly Arg Ser Gly His Gly Val Thr Val
                 470                 475                 480

 ctg gac aaa caa ata atg gtt ctt gga ggc ctt tgt tat aat ggt cat     1665
 Leu Asp Lys Gln Ile Met Val Leu Gly Gly Leu Cys Tyr Asn Gly His
             485                 490                 495

 tac agc gat tcc atc ctc act ttt gat ccg gat gaa aac aag tgg aag     1713
 Tyr Ser Asp Ser Ile Leu Thr Phe Asp Pro Asp Glu Asn Lys Trp Lys
         500                 505                 510

 gaa gat gag tac cct cgg atg ccc tgc aag ctg gat ggt tta caa gta     1761
 Glu Asp Glu Tyr Pro Arg Met Pro Cys Lys Leu Asp Gly Leu Gln Val
     515                 520                 525

 tgc aac ctg cat ttt ccg gac tat gta ctg gat gag gtc agg cgt tgc     1809
 Cys Asn Leu His Phe Pro Asp Tyr Val Leu Asp Glu Val Arg Arg Cys
 530                 535                 540                 545

 aac taa tgacatcctc ctccctaaaa aaagaggcaa acaaagtatt tgtttgcaca      1865
 Asn 






      <210> 146
      <211> 2076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (271)..(2076)

      <400> 146
 cctgttcagg ttgaggctac taaggccaga aagcagattt tcacttggga agagacgacc     60

 cgtagtatgg gatgtggtat gataccagca actggtctat tatatcattt aaaccacatg    120

 gctatctaaa gaggtatttg gctattataa ataaaatagt gatgaacacg tgtacaggtg    180

 tttgtacgga cataagttgt catttctctt gagtaaatac ctaaaagtgg gcttgctgga    240

 gttttactac ccttggatgc tgctgttgac     atg gaa aag att gag gaa caa     291
                                      Met Glu Lys Ile Glu Glu Gln
                                        1               5

 ttt gct aat ctg cac att gtt aaa tgt tcc tta gga acc aaa gag ccc      339
 Phe Ala Asn Leu His Ile Val Lys Cys Ser Leu Gly Thr Lys Glu Pro
          10                  15                  20

 act tac ctt ctt ggt ata gac aca tca aag act gtc caa gca gga aag      387
 Thr Tyr Leu Leu Gly Ile Asp Thr Ser Lys Thr Val Gln Ala Gly Lys
      25                  30                  35

 gaa aac ttg gtt gct gtt tta tgt tct aat gga tca atc aga ata tat      435
 Glu Asn Leu Val Ala Val Leu Cys Ser Asn Gly Ser Ile Arg Ile Tyr
  40                  45                  50                  55

 gat aaa gaa agg tta aat gta cta cga gaa ttt agt gga tat cct gga      483
 Asp Lys Glu Arg Leu Asn Val Leu Arg Glu Phe Ser Gly Tyr Pro Gly
                  60                  65                  70

 ctt ctt aat gga gtc aga ttt gca aat tcc tgt gac agt gta tat tca      531
 Leu Leu Asn Gly Val Arg Phe Ala Asn Ser Cys Asp Ser Val Tyr Ser
              75                  80                  85

 gca tgt act gat ggc act gtg aaa tgc tgg gat gct cga gta gcc aga      579
 Ala Cys Thr Asp Gly Thr Val Lys Cys Trp Asp Ala Arg Val Ala Arg
          90                  95                 100

 gaa aaa cct gtt cag ctc ttc aag ggt tac cct tcc aat att ttt atc      627
 Glu Lys Pro Val Gln Leu Phe Lys Gly Tyr Pro Ser Asn Ile Phe Ile
     105                 110                 115

 agt ttt gat att aat tgt aat gat cat att att tgt gct ggt aca gaa      675
 Ser Phe Asp Ile Asn Cys Asn Asp His Ile Ile Cys Ala Gly Thr Glu
 120                 125                 130                 135

 aaa gtt gat gat gat gca ttg ttg gtg ttt tgg gat gca agg atg aat      723
 Lys Val Asp Asp Asp Ala Leu Leu Val Phe Trp Asp Ala Arg Met Asn
                 140                 145                 150

 tct cag aat tta tct aca act aaa gac tca ctt ggt gca tat tca gag      771
 Ser Gln Asn Leu Ser Thr Thr Lys Asp Ser Leu Gly Ala Tyr Ser Glu
             155                 160                 165

 aca cat agt gat gat gtc act caa gta cgt ttc cat ccc agc aat ccc      819
 Thr His Ser Asp Asp Val Thr Gln Val Arg Phe His Pro Ser Asn Pro
         170                 175                 180

 aac atg gta gtc tca ggt tca tct gat ggc ctg gta aat gta ttt gat      867
 Asn Met Val Val Ser Gly Ser Ser Asp Gly Leu Val Asn Val Phe Asp
     185                 190                 195

 att aat att gat aat gag gag gat gca ctg gtt aca acc tgt aac tca      915
 Ile Asn Ile Asp Asn Glu Glu Asp Ala Leu Val Thr Thr Cys Asn Ser
 200                 205                 210                 215

 att tca tca gta agc tgt att ggt tgg tct ggg aaa ggt tat aaa cag      963
 Ile Ser Ser Val Ser Cys Ile Gly Trp Ser Gly Lys Gly Tyr Lys Gln
                 220                 225                 230

 att tac tgc atg aca cat gat gaa gga ttt tat tgg tgg gat ctt aat     1011
 Ile Tyr Cys Met Thr His Asp Glu Gly Phe Tyr Trp Trp Asp Leu Asn
             235                 240                 245

 cat ctg gac act gat gaa cca gtt aca cgt ttg aac atc cag gat gtc     1059
 His Leu Asp Thr Asp Glu Pro Val Thr Arg Leu Asn Ile Gln Asp Val
         250                 255                 260

 aga gaa gta gtt aac atg aaa gaa gat gct ttg gac tat ttg att ggt     1107
 Arg Glu Val Val Asn Met Lys Glu Asp Ala Leu Asp Tyr Leu Ile Gly
     265                 270                 275

 ggc cta tat cat gaa aag aca gac aca ttg cat gtt att gga gga aca     1155
 Gly Leu Tyr His Glu Lys Thr Asp Thr Leu His Val Ile Gly Gly Thr
 280                 285                 290                 295

 aac aaa gga agg att cat ttg atg aac tgc agc atg tca gga ctg acc     1203
 Asn Lys Gly Arg Ile His Leu Met Asn Cys Ser Met Ser Gly Leu Thr
                 300                 305                 310

 cat gtg act agc ctt cag gga ggg cat gct gct aca gtc cgt tct ttc     1251
 His Val Thr Ser Leu Gln Gly Gly His Ala Ala Thr Val Arg Ser Phe
             315                 320                 325

 tgt tgg aat gtg caa gat gat tct ttg ttg act gga gga gaa gat gca     1299
 Cys Trp Asn Val Gln Asp Asp Ser Leu Leu Thr Gly Gly Glu Asp Ala
         330                 335                 340

 cag ttg tta ctt tgg aaa cct gga gct ata gag aag acc ttt aca aag     1347
 Gln Leu Leu Leu Trp Lys Pro Gly Ala Ile Glu Lys Thr Phe Thr Lys
     345                 350                 355

 aaa gag agt atg aaa ata gca tcc tct gtg cac caa cga gta cga gtt     1395
 Lys Glu Ser Met Lys Ile Ala Ser Ser Val His Gln Arg Val Arg Val
 360                 365                 370                 375

 cat agt aat gat tct tat aaa aga agg aaa aag cag ctc ttt gga gct     1443
 His Ser Asn Asp Ser Tyr Lys Arg Arg Lys Lys Gln Leu Phe Gly Ala
                 380                 385                 390

 ggc ctt agc tcg gtc cgc ttc atc cgt gga acc caa agc atc cac aag     1491
 Gly Leu Ser Ser Val Arg Phe Ile Arg Gly Thr Gln Ser Ile His Lys
             395                 400                 405

 aat cta gaa gca aaa ata gcc cgc ttc cac cag cgg gag gat gcc atc     1539
 Asn Leu Glu Ala Lys Ile Ala Arg Phe His Gln Arg Glu Asp Ala Ile
         410                 415                 420

 ctc tat ccc agc tgt tgt gac gcc aac gcc ggc ctc ttt gag gtc ctg     1587
 Leu Tyr Pro Ser Cys Cys Asp Ala Asn Ala Gly Leu Phe Glu Val Leu
     425                 430                 435

 ctg aga ccc gag gac gca gtc ctg tcg gac gag ctg aac tgt gcc tcc     1635
 Leu Arg Pro Glu Asp Ala Val Leu Ser Asp Glu Leu Asn Cys Ala Ser
 440                 445                 450                 455

 atc atc cac ggc atc tgc ctg tgc aag gcc cac aag tac cac tat tgc     1683
 Ile Ile His Gly Ile Cys Leu Cys Lys Ala His Lys Tyr His Tyr Cys
                 460                 465                 470

 cac ctg gac gtg gcc tac cta gaa acc aag ctt cag gag gcc cag aag     1731
 His Leu Asp Val Ala Tyr Leu Glu Thr Lys Leu Gln Glu Ala Gln Lys
             475                 480                 485

 cat cgg ctg ttc ctg gtg gcc acc gat ggg gcc ttt tcc atg gat ggc     1779
 His Arg Leu Phe Leu Val Ala Thr Asp Gly Ala Phe Ser Met Asp Gly
         490                 495                 500

 gac atc gtg ccc ctg cag aag atc tgc cgc ctc gcc tct aga tat ggc     1827
 Asp Ile Val Pro Leu Gln Lys Ile Cys Arg Leu Ala Ser Arg Tyr Gly
     505                 510                 515

 gcc ctg gtc ttt gtg gat gaa tgc cat gcc act ggt ttc ctg gga ctc     1875
 Ala Leu Val Phe Val Asp Glu Cys His Ala Thr Gly Phe Leu Gly Leu
 520                 525                 530                 535

 aca gga cag ggc aca gat gag ctg ctg ggt gtg atg ggc cag gtc acc     1923
 Thr Gly Gln Gly Thr Asp Glu Leu Leu Gly Val Met Gly Gln Val Thr
                 540                 545                 550

 atc atc aac tcc acc ctg ggg aag gcc ctg ggt ggt gca tca ggg ggc     1971
 Ile Ile Asn Ser Thr Leu Gly Lys Ala Leu Gly Gly Ala Ser Gly Gly
             555                 560                 565

 tac acg aca ggg cct ggg ccc ctg gtg tca ctg ctg ctg ccc agc cct     2019
 Tyr Thr Thr Gly Pro Gly Pro Leu Val Ser Leu Leu Leu Pro Ser Pro
         570                 575                 580

 atc tct tct cca aca gtc tgc cac ctg ctg ttg ttg gct gca cct cta     2067
 Ile Ser Ser Pro Thr Val Cys His Leu Leu Leu Leu Ala Ala Pro Leu
     585                 590                 595

 agg ccc tag                                                         2076
 Arg Pro 
 600





      <210> 147
      <211> 7251
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (181)..(5187)

      <400> 147
 gtcctggacc aagacacaga cgccattgca gtccatgtag tcagagtgct gacctgcatc     60

 atgagtgact ccccctcggc caaggaggtg tttaaggagc gcatcggcta ccctcacctg    120

 caggaggttc tgcagagcca tggtcccccc acccatcggc tgttgcaaga gctgctcaac    180
                                                                 
 atg gct gtg gag ggt gac cac agc atg tgc cca cct cca cca atc cgc      228
 Met Ala Val Glu Gly Asp His Ser Met Cys Pro Pro Pro Pro Ile Arg
   1               5                  10                  15

 aac gag cag ccg gta ctg gtg ctg gcg cag tgg ctg ccg tca ttg ccc      276
 Asn Glu Gln Pro Val Leu Val Leu Ala Gln Trp Leu Pro Ser Leu Pro
              20                  25                  30

 acc gct gag ctg cgg ctc ttc cta gcg caa cgc ctc agg tgg ctc tgt      324
 Thr Ala Glu Leu Arg Leu Phe Leu Ala Gln Arg Leu Arg Trp Leu Cys
          35                  40                  45

 gac agc tgc cct gcc agc cgt gcc acc tgt gtg cag gca ggc ctg gtg      372
 Asp Ser Cys Pro Ala Ser Arg Ala Thr Cys Val Gln Ala Gly Leu Val
      50                  55                  60

 ggc tgc ctg ttg gag aca ctc agc aca ggg cta gcc ctg gag gcc cgc      420
 Gly Cys Leu Leu Glu Thr Leu Ser Thr Gly Leu Ala Leu Glu Ala Arg
  65                  70                  75                  80

 tgc caa gag cag ctg ctg gca ctg cta caa gca ctg ggc cgt gta tca      468
 Cys Gln Glu Gln Leu Leu Ala Leu Leu Gln Ala Leu Gly Arg Val Ser
                  85                  90                  95

 ata agg ccc atg gag ctg cgt cac ctg ctg cgc ccc cgg cca gga ttg      516
 Ile Arg Pro Met Glu Leu Arg His Leu Leu Arg Pro Arg Pro Gly Leu
             100                 105                 110

 gac tcg gaa cca ggc gga gct gag gct gga aag gcc cga cac gca ggt      564
 Asp Ser Glu Pro Gly Gly Ala Glu Ala Gly Lys Ala Arg His Ala Gly
         115                 120                 125

 gct gtc atc cgc aca tta tca ggc atg gcc agg cac cag ggt cct gca      612
 Ala Val Ile Arg Thr Leu Ser Gly Met Ala Arg His Gln Gly Pro Ala
     130                 135                 140

 cgt gct ctg cgc tac ttt gac ctc acg ccc agc atg gcg ggc atc atg      660
 Arg Ala Leu Arg Tyr Phe Asp Leu Thr Pro Ser Met Ala Gly Ile Met
 145                 150                 155                 160

 gta ccc cct gta cag cga tgg cca ggg cct ggc ttc acc ttt cat gcc      708
 Val Pro Pro Val Gln Arg Trp Pro Gly Pro Gly Phe Thr Phe His Ala
                 165                 170                 175

 tgg ctc tgt ctg cac cct atg gat aca gca cct acc cct gcc ccc acc      756
 Trp Leu Cys Leu His Pro Met Asp Thr Ala Pro Thr Pro Ala Pro Thr
             180                 185                 190

 cga cca ctc cag cga aag cag ctg tac agc ttc ttt acc agc agc ggc      804
 Arg Pro Leu Gln Arg Lys Gln Leu Tyr Ser Phe Phe Thr Ser Ser Gly
         195                 200                 205

 tca ggg ttt gag gcc ttc ttc acg gcg gcc ggg acc ctg gtg gtg gct      852
 Ser Gly Phe Glu Ala Phe Phe Thr Ala Ala Gly Thr Leu Val Val Ala
     210                 215                 220

 gtg tgc aca cgg aag gag tat ttg acc atg agt ttg ccc gaa gtg tcc      900
 Val Cys Thr Arg Lys Glu Tyr Leu Thr Met Ser Leu Pro Glu Val Ser
 225                 230                 235                 240

 ttt gcc gac tct gcc tgg cac tgc gtg gct atc gtc cat gtg cct ggg      948
 Phe Ala Asp Ser Ala Trp His Cys Val Ala Ile Val His Val Pro Gly
                 245                 250                 255

 cgc cgg ccc ttc agc cag aac ctg gtc cat gtc tac aaa gac ggc cat      996
 Arg Arg Pro Phe Ser Gln Asn Leu Val His Val Tyr Lys Asp Gly His
             260                 265                 270

 ctg gtc aag aca gca ccc ctt cgc tgc ccc tcc ctc agt gag cct ttc     1044
 Leu Val Lys Thr Ala Pro Leu Arg Cys Pro Ser Leu Ser Glu Pro Phe
         275                 280                 285

 tcc tcc tgc tgt atc ggc tcc gct gga tac cgc aca acg acc acc acc     1092
 Ser Ser Cys Cys Ile Gly Ser Ala Gly Tyr Arg Thr Thr Thr Thr Thr
     290                 295                 300

 aca ggg ctg ccc aca cca cca gtc ccc gcc acc ctg gcc tac act cac     1140
 Thr Gly Leu Pro Thr Pro Pro Val Pro Ala Thr Leu Ala Tyr Thr His
 305                 310                 315                 320

 ccc gcc ctc acc cgc tcc cag tca gtc cca gcc tcc aca ggg ctt ggc     1188
 Pro Ala Leu Thr Arg Ser Gln Ser Val Pro Ala Ser Thr Gly Leu Gly
                 325                 330                 335

 tgg ggg tcc ggg ctg gtg gcc ccc ctg cag gag ggc agc atc gac tct     1236
 Trp Gly Ser Gly Leu Val Ala Pro Leu Gln Glu Gly Ser Ile Asp Ser
             340                 345                 350

 acc ctc gca ggc acc cag gac act cgg tgg ggc agc ccc aca tcc ctg     1284
 Thr Leu Ala Gly Thr Gln Asp Thr Arg Trp Gly Ser Pro Thr Ser Leu
         355                 360                 365

 gag ggt gag ctg ggg gct gtg gcc atc ttt cac gaa gcc ctg cag gcg     1332
 Glu Gly Glu Leu Gly Ala Val Ala Ile Phe His Glu Ala Leu Gln Ala
     370                 375                 380

 acg gct ctg agg acc ctg tgc acc ctg ggg ccc aat gag acg gca ccc     1380
 Thr Ala Leu Arg Thr Leu Cys Thr Leu Gly Pro Asn Glu Thr Ala Pro
 385                 390                 395                 400

 ttc aag cct gag ggg gag ctg cat gag ctc agc acc agg ctg ctc ctc     1428
 Phe Lys Pro Glu Gly Glu Leu His Glu Leu Ser Thr Arg Leu Leu Leu
                 405                 410                 415

 cat tac tca cct cat gct tgt aag aac aac atc tgc ctg gac ctg tcc     1476
 His Tyr Ser Pro His Ala Cys Lys Asn Asn Ile Cys Leu Asp Leu Ser
             420                 425                 430

 ccc agt cat ggg ctt gat ggg cgc ctg acg ggc cac aga gtg gag acc     1524
 Pro Ser His Gly Leu Asp Gly Arg Leu Thr Gly His Arg Val Glu Thr
         435                 440                 445

 tgg gat gtg aag gat gtg gtg aac tgc gtt ggg ggt atg ggt gcc ctg     1572
 Trp Asp Val Lys Asp Val Val Asn Cys Val Gly Gly Met Gly Ala Leu
     450                 455                 460

 ctg ccc ctg ctg gag cga gta gct gca cag ccc aaa gag gct gaa gca     1620
 Leu Pro Leu Leu Glu Arg Val Ala Ala Gln Pro Lys Glu Ala Glu Ala
 465                 470                 475                 480

 ggt cca gct gaa acg cat gac ctc gtg ggt cct gaa ctg acc tct ggt     1668
 Gly Pro Ala Glu Thr His Asp Leu Val Gly Pro Glu Leu Thr Ser Gly
                 485                 490                 495

 cac aac acc cag ggc ctg gtt ctc cca ttg ggt aaa tct tca gag gaa     1716
 His Asn Thr Gln Gly Leu Val Leu Pro Leu Gly Lys Ser Ser Glu Glu
             500                 505                 510

 cgg atg gag agg aac gca gtg gct gct ttt ctg ctg atg ctg cgg aac     1764
 Arg Met Glu Arg Asn Ala Val Ala Ala Phe Leu Leu Met Leu Arg Asn
         515                 520                 525

 ttc ctt cag ggt cac atg gtg aac caa gag agc ctg gtg cag tgc cag     1812
 Phe Leu Gln Gly His Met Val Asn Gln Glu Ser Leu Val Gln Cys Gln
     530                 535                 540

 ggg cct gcc atc atc ggg gcc ctc ctg cga aag gtc cca agc tgg gcc     1860
 Gly Pro Ala Ile Ile Gly Ala Leu Leu Arg Lys Val Pro Ser Trp Ala
 545                 550                 555                 560

 atg gac atg aac gtg ctc atg tcc gcc cag ctg ctg atg gag cag gtg     1908
 Met Asp Met Asn Val Leu Met Ser Ala Gln Leu Leu Met Glu Gln Val
                 565                 570                 575

 gca gct gag ggc agc ggg ccc ctc ctg tac cta ctc tac cag cat ttg     1956
 Ala Ala Glu Gly Ser Gly Pro Leu Leu Tyr Leu Leu Tyr Gln His Leu
             580                 585                 590

 ctc ttc aac ttt cac ctc tgg acc ctc agt gac ttc gcc gtg cgc ctc     2004
 Leu Phe Asn Phe His Leu Trp Thr Leu Ser Asp Phe Ala Val Arg Leu
         595                 600                 605

 ggt cac atc cag tac atg tcc agc ata gtt cgg gag cac aga cag aag     2052
 Gly His Ile Gln Tyr Met Ser Ser Ile Val Arg Glu His Arg Gln Lys
     610                 615                 620

 ctg cgg aag aag tac ggc gtc cag ttt atc ttg gat gct ctg cgc acc     2100
 Leu Arg Lys Lys Tyr Gly Val Gln Phe Ile Leu Asp Ala Leu Arg Thr
 625                 630                 635                 640

 cac tac agc ccg cag cgg gag cgc ccc ctg gct gct gac gac cta cgc     2148
 His Tyr Ser Pro Gln Arg Glu Arg Pro Leu Ala Ala Asp Asp Leu Arg
                 645                 650                 655

 acc gtg cag acc tcc ctc ctg ggc ctg gcg agg gag ttc ctg gtg cgg     2196
 Thr Val Gln Thr Ser Leu Leu Gly Leu Ala Arg Glu Phe Leu Val Arg
             660                 665                 670

 agt ctc tca gca gat gac gtg cag gtc acg cag acc atg ctg agc ttt     2244
 Ser Leu Ser Ala Asp Asp Val Gln Val Thr Gln Thr Met Leu Ser Phe
         675                 680                 685

 ttg gcg gcc aca ggc gat gac ggt cag gcg gtg ggt gcg ctg gac ctg     2292
 Leu Ala Ala Thr Gly Asp Asp Gly Gln Ala Val Gly Ala Leu Asp Leu
     690                 695                 700

 ctg ctg gcc ctg ctg cac ggt tcc ctg gtg cag gag tcc ttg gct gtc     2340
 Leu Leu Ala Leu Leu His Gly Ser Leu Val Gln Glu Ser Leu Ala Val
 705                 710                 715                 720

 ttt ctg ttg gag cca ggg aac ctc gaa gtg cta ctg gcc ctg cta gtg     2388
 Phe Leu Leu Glu Pro Gly Asn Leu Glu Val Leu Leu Ala Leu Leu Val
                 725                 730                 735

 cgg cca ggg tca ctg ccc ctg ctg ccc gat cga gtc tgc aag atc ctg     2436
 Arg Pro Gly Ser Leu Pro Leu Leu Pro Asp Arg Val Cys Lys Ile Leu
             740                 745                 750

 cgc aga ctg cag cag aat gag cgg cta cct gag cgg agc cgc cag cgc     2484
 Arg Arg Leu Gln Gln Asn Glu Arg Leu Pro Glu Arg Ser Arg Gln Arg
         755                 760                 765

 ctc cgg ctg cgg gag tgt ggt ctc cag ggt ctg gtt gcc tgc ttg cct     2532
 Leu Arg Leu Arg Glu Cys Gly Leu Gln Gly Leu Val Ala Cys Leu Pro
     770                 775                 780

 gag ggg act gtt tcc ccc cag ctc tgc cag ggc ctc tac aag ctg ttc     2580
 Glu Gly Thr Val Ser Pro Gln Leu Cys Gln Gly Leu Tyr Lys Leu Phe
 785                 790                 795                 800

 ctg ggg gca gat tgc ctg aac ctc tca gat ctg ctg gct gtg gta cag     2628
 Leu Gly Ala Asp Cys Leu Asn Leu Ser Asp Leu Leu Ala Val Val Gln
                 805                 810                 815

 ctg tcc ctc cag gct gac ctc agc gtt cgc cta gac atc tgt cgc cag     2676
 Leu Ser Leu Gln Ala Asp Leu Ser Val Arg Leu Asp Ile Cys Arg Gln
             820                 825                 830

 ctt ttc cac ctc atc tac gga cag cca gat gta gtg cgg ctt ctg gcc     2724
 Leu Phe His Leu Ile Tyr Gly Gln Pro Asp Val Val Arg Leu Leu Ala
         835                 840                 845

 cga cag gct ggc tgg caa gat gtg ctg acc cgg cta tat gtc ctg gag     2772
 Arg Gln Ala Gly Trp Gln Asp Val Leu Thr Arg Leu Tyr Val Leu Glu
     850                 855                 860

 gct gcc aca gcc ggc agc ccc cct ccg tct tcc cca gag tca cct acc     2820
 Ala Ala Thr Ala Gly Ser Pro Pro Pro Ser Ser Pro Glu Ser Pro Thr
 865                 870                 875                 880

 tcc ccc aag cca gcc cca ccc aag cca ccc act gag tca cct gct gag     2868
 Ser Pro Lys Pro Ala Pro Pro Lys Pro Pro Thr Glu Ser Pro Ala Glu
                 885                 890                 895

 cct tca gat gtc ttc ctg ccc tca gag gcc ccc tgc cct gac cct gat     2916
 Pro Ser Asp Val Phe Leu Pro Ser Glu Ala Pro Cys Pro Asp Pro Asp
             900                 905                 910

 ggc ttt tac cat gct ctc tcc cca ttc tgc acg ccc ttt gac ctg ggc     2964
 Gly Phe Tyr His Ala Leu Ser Pro Phe Cys Thr Pro Phe Asp Leu Gly
         915                 920                 925

 ctg gaa cgg tct agt gta gga tca ggc aac act gct ggt ggt ggc ggc     3012
 Leu Glu Arg Ser Ser Val Gly Ser Gly Asn Thr Ala Gly Gly Gly Gly
     930                 935                 940

 agc agt ggg act ctt act cca gcc agc cag ccc ggc act cct tcg cca     3060
 Ser Ser Gly Thr Leu Thr Pro Ala Ser Gln Pro Gly Thr Pro Ser Pro
 945                 950                 955                 960

 ctg gat ggg ccg cgg ccc ttt cct gct gct cct ggc cgc cac agc tcc     3108
 Leu Asp Gly Pro Arg Pro Phe Pro Ala Ala Pro Gly Arg His Ser Ser
                 965                 970                 975

 agt ctc tcc aat gtg ctg gag gac ggc agc ctc ccg gag ccc acc att     3156
 Ser Leu Ser Asn Val Leu Glu Asp Gly Ser Leu Pro Glu Pro Thr Ile
             980                 985                 990

 agc ggg gat gat acc tcg aac acc agc aac cca cag caa acc tct gag     3204
 Ser Gly Asp Asp Thr Ser Asn Thr Ser Asn Pro Gln Gln Thr Ser Glu
         995                1000                1005

 gaa gag ttg tgc aat ctg ctc acc aac gtg ctg ttc tcg gtg acg tgg     3252
 Glu Glu Leu Cys Asn Leu Leu Thr Asn Val Leu Phe Ser Val Thr Trp
    1010                1015                1020

 cgt ggc gtg gaa ggc agc gat gag gct gcc tgg cgg gag cgt ggc cag     3300
 Arg Gly Val Glu Gly Ser Asp Glu Ala Ala Trp Arg Glu Arg Gly Gln
1025                1030                1035                1040

 gtt ttc tca gtg ctc acc cag ctg ggg gcc tca gcc aca ctt gtg cgc     3348
 Val Phe Ser Val Leu Thr Gln Leu Gly Ala Ser Ala Thr Leu Val Arg
                1045                1050                1055

 cca cca gac tgc atc aag cgc agc ctc ctg gag atg atg ctg gag tca     3396
 Pro Pro Asp Cys Ile Lys Arg Ser Leu Leu Glu Met Met Leu Glu Ser
            1060                1065                1070

 gcc ctg acc gac atc aaa gag gcc ccc gtg ggg gtc ctg gcc agc ctc     3444
 Ala Leu Thr Asp Ile Lys Glu Ala Pro Val Gly Val Leu Ala Ser Leu
        1075                1080                1085

 acc cag caa gcg ctt tgg ctg ctg cgt ctg ctg cag gac ttc ctg tgt     3492
 Thr Gln Gln Ala Leu Trp Leu Leu Arg Leu Leu Gln Asp Phe Leu Cys
    1090                1095                1100

 gct gaa ggc cat ggt aac cag gaa ctg tgg agt gag aag ctc ttt gaa     3540
 Ala Glu Gly His Gly Asn Gln Glu Leu Trp Ser Glu Lys Leu Phe Glu
1105                1110                1115                1120

 ggt gta tgc agc cta ctt gat cgc ctg gga gcc tgg ccc cac ctg gcc     3588
 Gly Val Cys Ser Leu Leu Asp Arg Leu Gly Ala Trp Pro His Leu Ala
                1125                1130                1135

 aac ggc aca gct gat ctc cgt gag atg gcg cag att ggc cta cgg ctt     3636
 Asn Gly Thr Ala Asp Leu Arg Glu Met Ala Gln Ile Gly Leu Arg Leu
            1140                1145                1150

 gta ctt ggc tac atc ctg ctg gaa gac cca cag ctg cat gcc cag gcc     3684
 Val Leu Gly Tyr Ile Leu Leu Glu Asp Pro Gln Leu His Ala Gln Ala
        1155                1160                1165

 tac gtg aga ttg cac atg ctg cta cag act gca gtg cca gcc cgc cgc     3732
 Tyr Val Arg Leu His Met Leu Leu Gln Thr Ala Val Pro Ala Arg Arg
    1170                1175                1180

 gag gag gcc tgc tat gtg ctc tcc aag ctg gag gct gca ctg ggg cgg     3780
 Glu Glu Ala Cys Tyr Val Leu Ser Lys Leu Glu Ala Ala Leu Gly Arg
1185                1190                1195                1200

 gtg ctg aac acc tct tcc ttg gag tca gcc act gat gag gca ggg tcc     3828
 Val Leu Asn Thr Ser Ser Leu Glu Ser Ala Thr Asp Glu Ala Gly Ser
                1205                1210                1215

 cca ctt gca gct gca gca gct gca gca gct gca gag cgc tgc tcc tgg     3876
 Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Arg Cys Ser Trp
            1220                1225                1230

 ctg gta cca ctg gtg cgc acg ctg cta gac cgt gcc tat gag ccg ctg     3924
 Leu Val Pro Leu Val Arg Thr Leu Leu Asp Arg Ala Tyr Glu Pro Leu
        1235                1240                1245

 ggg ctg cag tgg gga ctg ccc tcc ctg cca ccc acc aat ggc agc ccc     3972
 Gly Leu Gln Trp Gly Leu Pro Ser Leu Pro Pro Thr Asn Gly Ser Pro
    1250                1255                1260

 acc ttc ttt gaa gac ttc cag gct ttt tgt gcc aca ccc gaa tgg cgc     4020
 Thr Phe Phe Glu Asp Phe Gln Ala Phe Cys Ala Thr Pro Glu Trp Arg
1265                1270                1275                1280

 cac ttc atc gac aaa cag gta cag cca acc atg tcc cag ttc gaa atg     4068
 His Phe Ile Asp Lys Gln Val Gln Pro Thr Met Ser Gln Phe Glu Met
                1285                1290                1295

 gac acg tat gct aag agc cac gac ctt atg tca ggt ttc tgg aat gcc     4116
 Asp Thr Tyr Ala Lys Ser His Asp Leu Met Ser Gly Phe Trp Asn Ala
            1300                1305                1310

 tgc tat gac atg ctt atg agc agt ggg cag cgg cgc cag tgg gag cgc     4164
 Cys Tyr Asp Met Leu Met Ser Ser Gly Gln Arg Arg Gln Trp Glu Arg
        1315                1320                1325

 gcc cag agt cgt cgg gcc ttc cag gag ctg gtg ctg gaa cct gcg cag     4212
 Ala Gln Ser Arg Arg Ala Phe Gln Glu Leu Val Leu Glu Pro Ala Gln
    1330                1335                1340

 agg cgg gcg cgc ctg gag ggg cta cgc tac acg gca gtg ctg aag cag     4260
 Arg Arg Ala Arg Leu Glu Gly Leu Arg Tyr Thr Ala Val Leu Lys Gln
1345                1350                1355                1360

 cag gca acg cag cac tcc atg gcc ctg ctg cac tgg ggg gcg ctg tgg     4308
 Gln Ala Thr Gln His Ser Met Ala Leu Leu His Trp Gly Ala Leu Trp
                1365                1370                1375

 cgc cag ctc gcc agc cca tgt ggg gcc tgg gcg ctg agg gac act ccc     4356
 Arg Gln Leu Ala Ser Pro Cys Gly Ala Trp Ala Leu Arg Asp Thr Pro
            1380                1385                1390

 atc ccc cgc tgg aaa ctg tcc agc gcc gag aca tat tca cgc atg cgt     4404
 Ile Pro Arg Trp Lys Leu Ser Ser Ala Glu Thr Tyr Ser Arg Met Arg
        1395                1400                1405

 ctg aag ctg gtg ccc aac cat cac ttc gac cct cac ctg gaa gcc agc     4452
 Leu Lys Leu Val Pro Asn His His Phe Asp Pro His Leu Glu Ala Ser
    1410                1415                1420

 gct ctc cga gac aat ctg ggt gag gtt ccc ctg aca ccc acc gag gag     4500
 Ala Leu Arg Asp Asn Leu Gly Glu Val Pro Leu Thr Pro Thr Glu Glu
1425                1430                1435                1440

 gcc tca ctg cct ctg gca gtg acc aaa gag gcc aaa gtg agc acc cca     4548
 Ala Ser Leu Pro Leu Ala Val Thr Lys Glu Ala Lys Val Ser Thr Pro
                1445                1450                1455

 ccc gag ttg ctg cag gag gac cag ctc ggc gag gac gag ctg gct gag     4596
 Pro Glu Leu Leu Gln Glu Asp Gln Leu Gly Glu Asp Glu Leu Ala Glu
            1460                1465                1470

 ctg gag acc ccg atg gag gca gca gaa ctg gat gag cag cgt gag aag     4644
 Leu Glu Thr Pro Met Glu Ala Ala Glu Leu Asp Glu Gln Arg Glu Lys
        1475                1480                1485

 ctg gtg ctg tcg gcc gag tgc cag ctg gtg acg gta gtg gcc gtg gtc     4692
 Leu Val Leu Ser Ala Glu Cys Gln Leu Val Thr Val Val Ala Val Val
    1490                1495                1500

 cca ggg ctg ctg gag gtc acc aca cag aat gta tac ttc tac gat ggc     4740
 Pro Gly Leu Leu Glu Val Thr Thr Gln Asn Val Tyr Phe Tyr Asp Gly
1505                1510                1515                1520

 agc act gag cgc gtg gaa acc gag gag ggc atc ggc tat gat ttc cgg     4788
 Ser Thr Glu Arg Val Glu Thr Glu Glu Gly Ile Gly Tyr Asp Phe Arg
                1525                1530                1535

 cgc cca ctg gcc cag ctg cgt gag gtc cac ctg cgg cgt ttc aac ctg     4836
 Arg Pro Leu Ala Gln Leu Arg Glu Val His Leu Arg Arg Phe Asn Leu
            1540                1545                1550

 cgc cgt tca gca ctt gag ctc ttc ttt atc gat cag gcc aac tac ttc     4884
 Arg Arg Ser Ala Leu Glu Leu Phe Phe Ile Asp Gln Ala Asn Tyr Phe
        1555                1560                1565

 ctc aac ttc cca tgc aag gtg ggc acg acc cca gtc tca tct cct agc     4932
 Leu Asn Phe Pro Cys Lys Val Gly Thr Thr Pro Val Ser Ser Pro Ser
    1570                1575                1580

 cag act ccg aga ccc cag cct ggc ccc atc cca ccc cat acc cag gta     4980
 Gln Thr Pro Arg Pro Gln Pro Gly Pro Ile Pro Pro His Thr Gln Val
1585                1590                1595                1600

 cgg aac cag gtg tac tcg tgg ctc ctg cgc cta cgg ccc ccc tct caa     5028
 Arg Asn Gln Val Tyr Ser Trp Leu Leu Arg Leu Arg Pro Pro Ser Gln
                1605                1610                1615

 ggc tac cta agc agc cgc tcc ccc cag gag atg ctg cgt gcc tca ggc     5076
 Gly Tyr Leu Ser Ser Arg Ser Pro Gln Glu Met Leu Arg Ala Ser Gly
            1620                1625                1630

 ctt acc cag aaa tgg gta cag cgt gag ata tcc aac ttc gag tac ttg     5124
 Leu Thr Gln Lys Trp Val Gln Arg Glu Ile Ser Asn Phe Glu Tyr Leu
        1635                1640                1645

 atg caa ctc aac acc att gcg ggg cgg acc tac aat gac ctg tct cag     5172
 Met Gln Leu Asn Thr Ile Ala Gly Arg Thr Tyr Asn Asp Leu Ser Gln
    1650                1655                1660

 tac cct gtg gta tga aagctttgag gacccagcag ggaccattga caagttccac     5227
 Tyr Pro Val Val 
1665

 tatggcaccc actactccaa tgcagcaggt gtgatgcact acctcatccg cgtggagccc   5287

 ttcacctccc tgcacgtcca gctgcaaagt ggccgctttg actgctccga ccggcagttc   5347

 cactcggtgg cggcagcctg gcaggcacgc ctggagagcc ctgccgatgt gaaggagctc   5407

 atcccggaat tcttctactt tcctgacttc ctggagaacc agaacggttt tgacctgggc   5467

 tgtctccagc tgaccaacga gaaggtaggc gatgtggtgc tacccccgtg ggccagctct   5527

 cctgaggact tcatccagca gcaccgccag gctctggagt cggagtatgt gtctgcacac   5587

 ctacacgagt ggatcgacct catctttggc tacaagcagc gggggccagc cgccgaggag   5647

 gccctcaatg tcttctatta ctgcacctat gagggggctg tagacctgga ccatgtgaca   5707

 gatgagcggg aacggaaggc tctggagggc attatcagca actttgggca gactccctgt   5767

 cagctgctga aggagccaca tccaactcgg ctctcagctg aggaagcagc ccatcgcctt   5827

 gcacgcctgg acactaactc acctagcatc ttccagcacc tggacgaact caaggcattc   5887

 ttcgcagagg ttgtcagtga tggtgtaccc ctggtgctag ccctggtccc ccaccggcag   5947

 ccccactcct tcatcaccca gggttcccca gacctgttgg tgactgtgag tgccagtggg   6007

 ctgctgggca cccacagctg gttgccctat gaccgcaaca taagcaacta cttcagcttc   6067

 agcaaagacc ccaccatggg cagccacaag acgcagcgac tgctgagtgg cccgtgggtg   6127

 ccaggcagtg gtgtgagtgg acaagcactg gcagtggccc cggatggaaa gctgctattc   6187

 agcggtggcc actgggatgg cagcctgcgg gtgactgcac taccccgtgg caagctgttg   6247

 agccagctca gctgccacct tgatgtagta acctgccttg cactggacac ctgtggcatc   6307

 tacctcatct caggctcccg ggacaccacg tgcatggtgt ggcggctcct gcatcagggt   6367

 ggtctgtcag taggcctggc accaaagcct gtgcaggtcc tgtatgggca tggggctgca   6427

 gtgagctgtg tggccatcag cactgaactt gacatggctg tgtctggatc tgaggatgga   6487

 actgtgatca tacacactgt acgccgcgga cagtttgtag cggcactacg gcctctgggt   6547

 gccacattcc ctggacctat tttccacctg gcattggggt ccgaaggcca gattgtggta   6607

 cagagctcag cgtgggaacg tcctggggcc caggtcacct actccttgca cctgtattca   6667

 gtcaatggga agttgcgggc ttcactgccc ctggcagagc agcctacagc cctgacggtg   6727

 acagaggact ttgtgttgct gggcaccgcc cagtgcgccc tgcacatcct ccaactaaac   6787

 acactgctcc cggccgcgcc tcccttgccc atgaaggtgg ccatccgcag cgtggccgtg   6847

 accaaggagc gcagccacgt gctggtgggc ctggaggatg gcaagctcat cgtggtggtc   6907

 gcggggcagc cctctgaggt gcgcagcagc cagttcgcgc ggaagctgtg gcggtcctcg   6967

 cggcgcatct cccaggtgtc ctcgggagag acggaataca accctactga ggcgcgctga   7027

 acctggccag tccggctgct cgggccccgc ccccggcagg cctggcccgg gaggccccgc   7087

 ccagaagtcg gcgggaacac cccggggtgg gcagcccagg ggggtgagcg gggcccaccc   7147

 tgcccagctc agggattggc gggcgatgtt accccctcag ggattggcgg gcggaagtcc   7207

 cgcccctcgc cggctgaggg gccgccctga gggccagcac tggc                    7251




      <210> 148
      <211> 1410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(1356)

      <400> 148
 ggggtttgat gaacccggtt cccggggaga ctggtacggt tgctgtgtgc t atg gag      57
                                                          Met Glu
                                                            1

 ccg agg gtc gtc aag cca ccg ggg cag gat tta gta gtg gag agt ctc      105
 Pro Arg Val Val Lys Pro Pro Gly Gln Asp Leu Val Val Glu Ser Leu
           5                  10                  15

 aaa agc cgc tac gga ctc ggg ggc agc tgc ccc gac gag tat gat ttt      153
 Lys Ser Arg Tyr Gly Leu Gly Gly Ser Cys Pro Asp Glu Tyr Asp Phe
      20                  25                  30

 tca aat ttt tat cag tct aag tat aag aga aga act cta acc tcc cca      201
 Ser Asn Phe Tyr Gln Ser Lys Tyr Lys Arg Arg Thr Leu Thr Ser Pro
  35                  40                  45                  50

 ggt gat ttg gat atc tac tct gga gat aaa gtt ggt tca tcg tta aaa      249
 Gly Asp Leu Asp Ile Tyr Ser Gly Asp Lys Val Gly Ser Ser Leu Lys
                  55                  60                  65

 tat tct gat gaa agc aag cat tgt aga aca cca ttg ggc agc tta ttc      297
 Tyr Ser Asp Glu Ser Lys His Cys Arg Thr Pro Leu Gly Ser Leu Phe
              70                  75                  80

 aag cac gta aat gtg aat tgc cta gat gat gaa ctg gat tct ttc cat      345
 Lys His Val Asn Val Asn Cys Leu Asp Asp Glu Leu Asp Ser Phe His
          85                  90                  95

 gat ttg aag aaa cag gaa aca gaa gaa gag tta att gaa aat gat tat      393
 Asp Leu Lys Lys Gln Glu Thr Glu Glu Glu Leu Ile Glu Asn Asp Tyr
     100                 105                 110

 aga gtt agt acc tcg aaa ata acc aag cag tct ttt aaa gaa ata gaa      441
 Arg Val Ser Thr Ser Lys Ile Thr Lys Gln Ser Phe Lys Glu Ile Glu
 115                 120                 125                 130

 aaa gtt gcc ttg cca act aat acg acc tca tcg aga cct cgg act gag      489
 Lys Val Ala Leu Pro Thr Asn Thr Thr Ser Ser Arg Pro Arg Thr Glu
                 135                 140                 145

 tgt tgt agt gat gca ggt gac tct cct ttg aaa cct gtc agc tgt cca      537
 Cys Cys Ser Asp Ala Gly Asp Ser Pro Leu Lys Pro Val Ser Cys Pro
             150                 155                 160

 aaa tct aaa gca tca gac aag cgg agt tta ctt cca cat cag atc agt      585
 Lys Ser Lys Ala Ser Asp Lys Arg Ser Leu Leu Pro His Gln Ile Ser
         165                 170                 175

 cag ata tat gac gaa tta ttt cag ata cat ctg aaa ttg cag tgt gaa      633
 Gln Ile Tyr Asp Glu Leu Phe Gln Ile His Leu Lys Leu Gln Cys Glu
     180                 185                 190

 act gca gca caa cag aaa ttt gct gaa gaa ctt caa aag cga gaa cgt      681
 Thr Ala Ala Gln Gln Lys Phe Ala Glu Glu Leu Gln Lys Arg Glu Arg
 195                 200                 205                 210

 ttt tta ctt gaa aga gaa caa ctg ctt ttc aga cat gaa aat gcc ttg      729
 Phe Leu Leu Glu Arg Glu Gln Leu Leu Phe Arg His Glu Asn Ala Leu
                 215                 220                 225

 agt aaa att aaa ggt gtt gaa gaa gag gtt ctt aca aga ttt caa att      777
 Ser Lys Ile Lys Gly Val Glu Glu Glu Val Leu Thr Arg Phe Gln Ile
             230                 235                 240

 ata aaa gag cag cat gat gca gaa gtt gaa cac tta acc gaa gtt ctt      825
 Ile Lys Glu Gln His Asp Ala Glu Val Glu His Leu Thr Glu Val Leu
         245                 250                 255

 aag gaa aag aat aaa gaa acc aag aga ctg agg tcc tct ttt gat gca      873
 Lys Glu Lys Asn Lys Glu Thr Lys Arg Leu Arg Ser Ser Phe Asp Ala
     260                 265                 270

 ttg aaa gaa ttg aat gat acc tta aaa aaa cag tta aat gaa gca agt      921
 Leu Lys Glu Leu Asn Asp Thr Leu Lys Lys Gln Leu Asn Glu Ala Ser
 275                 280                 285                 290

 gaa gaa aac agg aag ata gac att cag gct aaa aga gtt caa gca cgt      969
 Glu Glu Asn Arg Lys Ile Asp Ile Gln Ala Lys Arg Val Gln Ala Arg
                 295                 300                 305

 tta gat aat tta cag agg aag tac gag ttt atg aca ata cag aga ttg     1017
 Leu Asp Asn Leu Gln Arg Lys Tyr Glu Phe Met Thr Ile Gln Arg Leu
             310                 315                 320

 aaa gga agt tcc cat gct gtt cat gaa atg aaa agt tta aaa caa gaa     1065
 Lys Gly Ser Ser His Ala Val His Glu Met Lys Ser Leu Lys Gln Glu
         325                 330                 335

 aaa gca cca gtt tca aaa act tac aag gta cca ctt aat ggg caa gtt     1113
 Lys Ala Pro Val Ser Lys Thr Tyr Lys Val Pro Leu Asn Gly Gln Val
     340                 345                 350

 tat gaa ctt tta act gtc ttc atg gac tgg att tcg gat cat cat ctt     1161
 Tyr Glu Leu Leu Thr Val Phe Met Asp Trp Ile Ser Asp His His Leu
 355                 360                 365                 370

 agc aaa gtg aaa cat gaa gaa tct gga atg gat ggt aaa aaa cca caa     1209
 Ser Lys Val Lys His Glu Glu Ser Gly Met Asp Gly Lys Lys Pro Gln
                 375                 380                 385

 ctc aaa ttt gct tcc cag aga aat gat att cag gag aag tgt gta aag     1257
 Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile Gln Glu Lys Cys Val Lys
             390                 395                 400

 aat cct tgc agc ctt tcc tgg aag cct gta gca act ctt tat ttt ttc     1305
 Asn Pro Cys Ser Leu Ser Trp Lys Pro Val Ala Thr Leu Tyr Phe Phe
         405                 410                 415

 gta ctt gct ctg tgc tgc ttc gag ccc cta agc ttg atc ttc aaa tac     1353
 Val Leu Ala Leu Cys Cys Phe Glu Pro Leu Ser Leu Ile Phe Lys Tyr
     420                 425                 430

 tag aaaa actcagtatt attttacaga aactttccaa aatcaagagt aataagaagc     1410
 






      <210> 149
      <211> 590
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (276)..(536)

      <400> 149
 tggcttgtcc cgcccctgcc cctgagtgac agaaccgtgg acagcaacat ttcccacagg     60

 acacgaagtt tgtcggccct tgccttggca gagctgagta agaaaaatca ccaagaatat    120

 tatttttggt atttggaatt gaatttgcca ggaatgcaag cactgctacc taactaaaga    180

 ccttggcttt ggaaacatct taccccttgg cagctctcca gagtttagac ttggcagcat    240

 caaagacaca acgcaaggca ttttggagat caaag   atg ggt aga aaa gat gct     293
                                          Met Gly Arg Lys Asp Ala
                                            1               5

 gct act ata aaa ctt cct gtt gat cag tac aga aaa caa att ggt aaa      341
 Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr Arg Lys Gln Ile Gly Lys
              10                  15                  20

 cag gat tat aaa aaa act aaa cct att tta cga gca acc aaa tta aaa      389
 Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu Arg Ala Thr Lys Leu Lys
          25                  30                  35

 gca gaa gca aag aaa aca gca ata ggc ata aag gaa gtt ggc ctt gta      437
 Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile Lys Glu Val Gly Leu Val
      40                  45                  50

 ctt gca gct ata ttg gca cta cta ctg gct ttc tat gct ttc ttt tat      485
 Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala Phe Tyr Ala Phe Phe Tyr
  55                  60                  65                  70

 ctc aga ctc acc acg gat gtt gac cct gat ctg gac caa gat gaa gat      533
 Leu Arg Leu Thr Thr Asp Val Asp Pro Asp Leu Asp Gln Asp Glu Asp
                  75                  80                  85

 tag ctaa gcaacaatca atgcatgaaa gagaaataac tttacgaaag caccttttgg      590
 






      <210> 150
      <211> 817
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (140)..(631)

      <400> 150
 gggcctagcc aaaaggggcg ggcgagcacg gcccgcggcg gcgcgttcgc tggagctggt     60

 ggaccgggcg gctgaccgag gggcggacgc gcggcggggc agaccgctgg ggactgcggg    120

 cggcgctgtg tccgtcgcc atg aca gat cag acc tat tgt gac cgc ctg gtg     172
                      Met Thr Asp Gln Thr Tyr Cys Asp Arg Leu Val
                        1               5                  10

 cag gac acg cct ttc ctg aca ggc cat ggg cgc ttg agt gag cag cag      220
 Gln Asp Thr Pro Phe Leu Thr Gly His Gly Arg Leu Ser Glu Gln Gln
              15                  20                  25

 gtg gac agg atc atc ctc cag ctg aac cgt tac tac cca cag atc ctt      268
 Val Asp Arg Ile Ile Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu
          30                  35                  40

 acc aac aag gag gcg gaa aag ttc cgg aac ccc aag gca tcc ttg cgt      316
 Thr Asn Lys Glu Ala Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg
      45                  50                  55

 gtg cgg ctc tgt gac ctc ctg agc cac ctg cag cgg agc ggt gag cgg      364
 Val Arg Leu Cys Asp Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg
  60                  65                  70                  75

 gac tgc cag gag ttc tac cga gcc ctg tat atc cat gcc cag ccc ctg      412
 Asp Cys Gln Glu Phe Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu
                  80                  85                  90

 cac agc cgc ctg ccc agc cgc cac gct ctg cga ccc atg agc ttc ctg      460
 His Ser Arg Leu Pro Ser Arg His Ala Leu Arg Pro Met Ser Phe Leu
              95                 100                 105

 gct ggc ctg ggc ctt gct gtg gga ctg gcc ctg ctc ctg tac tgc tat      508
 Ala Gly Leu Gly Leu Ala Val Gly Leu Ala Leu Leu Leu Tyr Cys Tyr
         110                 115                 120

 ccg cca gac ccc aag ggc ctg cca ggg acc cgg cgc gtc ctc ggt ttc      556
 Pro Pro Asp Pro Lys Gly Leu Pro Gly Thr Arg Arg Val Leu Gly Phe
     125                 130                 135

 tcg cct gtc atc atc gac aga cat gtc agc cgc tac ctg ctg gcc ttc      604
 Ser Pro Val Ile Ile Asp Arg His Val Ser Arg Tyr Leu Leu Ala Phe
 140                 145                 150                 155

 ctg gca gat gac cta ggg ggg ctc tga cagac cctggaccca gggcctcacc      656
 Leu Ala Asp Asp Leu Gly Gly Leu 
                 160

 tgccactcaa ccaaagagtc ctcgagccgg cccgccaagg ggactgctgc ttctttttct    716

 aaatgcatat ttttcattat ttataatttg tgtaaaaaac acaccttcac cttacaaggt    776

 gctgaccata ttaaatgttc aagttctctc aaaaaaaaaa a                        817




      <210> 151
      <211> 1414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(1033)

      <400> 151
 tgtcgttgtt ctgaggggga agagcagagc c   atg cct gcc cca cac ggg ctg      52
                                      Met Pro Ala Pro His Gly Leu
                                        1               5

 gcc gcc aga gcc acc tct ctc tca ggc agg gcg gtg gca gag agt tgg      100
 Ala Ala Arg Ala Thr Ser Leu Ser Gly Arg Ala Val Ala Glu Ser Trp
          10                  15                  20

 cat cag tcg cag ccc tgt tct ccc tcc tta ccc agg ggc tcc gcc tat      148
 His Gln Ser Gln Pro Cys Ser Pro Ser Leu Pro Arg Gly Ser Ala Tyr
      25                  30                  35

 gcc aac atc atc tcc cag ttt gca cag acc gtc ttc ctc ctt ctc tac      196
 Ala Asn Ile Ile Ser Gln Phe Ala Gln Thr Val Phe Leu Leu Leu Tyr
  40                  45                  50                  55

 att gtg ctg aag aag ctg cac ctg gag acg tgg gca ggt tgg tcc agc      244
 Ile Val Leu Lys Lys Leu His Leu Glu Thr Trp Ala Gly Trp Ser Ser
                  60                  65                  70

 cag tgc ctg cag gac tgg ggc ccc ttc ttc tcc ctg gct gtc ccc agc      292
 Gln Cys Leu Gln Asp Trp Gly Pro Phe Phe Ser Leu Ala Val Pro Ser
              75                  80                  85

 atg ctc atg atc tgt gtt gag tgg tgg gcc tat gag atc ggg agc ttc      340
 Met Leu Met Ile Cys Val Glu Trp Trp Ala Tyr Glu Ile Gly Ser Phe
          90                  95                 100

 ctc atg ggg ctg ctc agt gtg gtg gat ctc tct gcc cag gct gtc atc      388
 Leu Met Gly Leu Leu Ser Val Val Asp Leu Ser Ala Gln Ala Val Ile
     105                 110                 115

 tat gag gtg gcc act gtg acc tac atg att ccc ttg ggg ctc agc atc      436
 Tyr Glu Val Ala Thr Val Thr Tyr Met Ile Pro Leu Gly Leu Ser Ile
 120                 125                 130                 135

 ggg gtc tgt gtc cga gtg ggg atg gct ctg ggg gct gcg gat act gtg      484
 Gly Val Cys Val Arg Val Gly Met Ala Leu Gly Ala Ala Asp Thr Val
                 140                 145                 150

 cag gcc aag cgc tcg gcc gtc tcg ggc gtg ctc agc ata gtt ggc att      532
 Gln Ala Lys Arg Ser Ala Val Ser Gly Val Leu Ser Ile Val Gly Ile
             155                 160                 165

 tcc ctg gtc ctg ggc acc ctg ata agc atc ctg aaa aat cag ctg ggg      580
 Ser Leu Val Leu Gly Thr Leu Ile Ser Ile Leu Lys Asn Gln Leu Gly
         170                 175                 180

 cat att ttt acc aat gat gaa gat gtc att gcc ctg gtg agc cag gtc      628
 His Ile Phe Thr Asn Asp Glu Asp Val Ile Ala Leu Val Ser Gln Val
     185                 190                 195

 ttg ccg gtt tat agt gtc ttt cac gtg ttt gag gcc atc tgt tgt gtc      676
 Leu Pro Val Tyr Ser Val Phe His Val Phe Glu Ala Ile Cys Cys Val
 200                 205                 210                 215

 tat ggc gga gtt ctg aga gga act ggg aag cag gcc ttt ggt gcc gct      724
 Tyr Gly Gly Val Leu Arg Gly Thr Gly Lys Gln Ala Phe Gly Ala Ala
                 220                 225                 230

 gtg aat gcc atc aca tat tac atc atc ggc cta cca ctg ggc atc ctt      772
 Val Asn Ala Ile Thr Tyr Tyr Ile Ile Gly Leu Pro Leu Gly Ile Leu
             235                 240                 245

 ctg acc ttt gtg gtc aga atg aga atc atg ggc ctc tgg ctg ggc atg      820
 Leu Thr Phe Val Val Arg Met Arg Ile Met Gly Leu Trp Leu Gly Met
         250                 255                 260

 ctg gcc tgt gtc ttc ctg gca act gct gcc ttt gtt gct tat act gcc      868
 Leu Ala Cys Val Phe Leu Ala Thr Ala Ala Phe Val Ala Tyr Thr Ala
     265                 270                 275

 cgg ctg gac tgg aag ctt gct gca gag gag gct aag aaa cat tca ggc      916
 Arg Leu Asp Trp Lys Leu Ala Ala Glu Glu Ala Lys Lys His Ser Gly
 280                 285                 290                 295

 cgg cag cag cag cag aga gca gag agc act gca acc aga cct ggg gct      964
 Arg Gln Gln Gln Gln Arg Ala Glu Ser Thr Ala Thr Arg Pro Gly Ala
                 300                 305                 310

 gct ctg ggg gcg gcg tca gcc aca ctg atg gtg ggg ctc acg gtc agg     1012
 Ala Leu Gly Ala Ala Ser Ala Thr Leu Met Val Gly Leu Thr Val Arg
             315                 320                 325

 atc cta gcc acc agg cac tag ca aagaagcttg gaaatagaaa gccaggagtg     1065
 Ile Leu Ala Thr Arg His 
         330

 gctgtcccca gtatgcaaac acaccacggt ctgccctgca aaaacaccaa tggggtctag   1125

 tgcaggtgga cactttgaac cactcctcaa aaaaagaact ttggctgatt ccttgtggtg   1185

 acactcagag gggtctgaac agacttgaca attctgttct ggtcaagctg gagttttctt   1245

 ctgtgacttg gactgctcta cagaagacat cagccaactg cacgagtcag agtccaggga   1305

 ttgtcactat tattaataat gtaaatggct tcaaatggga cactgcagat aaaatcacaa   1365

 aaaccactgt tatattaaag attacacatt tcctgggaaa aaaaaaaaa               1414




      <210> 152
      <211> 1261
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (32)..(1207)

      <400> 152
 tgtcgttgtt ctgaggggga agagcagagc c   atg cct gcc cca cac ggg ctg      52
                                      Met Pro Ala Pro His Gly Leu
                                        1               5

 gcc gcc aga gcc acc tct ctc tca ggc agg gcg gtg gca gag agt tgg      100
 Ala Ala Arg Ala Thr Ser Leu Ser Gly Arg Ala Val Ala Glu Ser Trp
          10                  15                  20

 cat cag tcg cag ccc tgt tct ccc tcc tta ccc agg ggc tcc gcc tat      148
 His Gln Ser Gln Pro Cys Ser Pro Ser Leu Pro Arg Gly Ser Ala Tyr
      25                  30                  35

 gcc aac atc atc tcc cag ttt gca cag acc gtc ttc ctc ctt ctc tac      196
 Ala Asn Ile Ile Ser Gln Phe Ala Gln Thr Val Phe Leu Leu Leu Tyr
  40                  45                  50                  55

 att gtg ctg aag aag ctg cac ctg gag acg tgg gca ggt tgg tcc agc      244
 Ile Val Leu Lys Lys Leu His Leu Glu Thr Trp Ala Gly Trp Ser Ser
                  60                  65                  70

 cag tgc ctg cag gac tgg ggc ccc ttc ttc tcc ctg gct gtc ccc agc      292
 Gln Cys Leu Gln Asp Trp Gly Pro Phe Phe Ser Leu Ala Val Pro Ser
              75                  80                  85

 atg ctc atg atc tgt gtt gag tgg tgg gcc tat gag atc ggg agc ttc      340
 Met Leu Met Ile Cys Val Glu Trp Trp Ala Tyr Glu Ile Gly Ser Phe
          90                  95                 100

 ctc atg ggg ctg ctc agt gtg gtg gat ctc tct gcc cag gct gtc atc      388
 Leu Met Gly Leu Leu Ser Val Val Asp Leu Ser Ala Gln Ala Val Ile
     105                 110                 115

 tat gag gtg gcc act gtg acc tac atg att ccc ttg ggg ctc agc atc      436
 Tyr Glu Val Ala Thr Val Thr Tyr Met Ile Pro Leu Gly Leu Ser Ile
 120                 125                 130                 135

 ggg gtc tgt gtc cga gtg ggg atg gct ctg ggg gct gcg gat act gtg      484
 Gly Val Cys Val Arg Val Gly Met Ala Leu Gly Ala Ala Asp Thr Val
                 140                 145                 150

 cag gcc aag cgc tcg gcc gtc tcg ggc gtg ctc agc ata gtt ggc att      532
 Gln Ala Lys Arg Ser Ala Val Ser Gly Val Leu Ser Ile Val Gly Ile
             155                 160                 165

 tcc ctg gtc ctg ggc acc ctg ata agc atc ctg aaa aat cag ctg ggg      580
 Ser Leu Val Leu Gly Thr Leu Ile Ser Ile Leu Lys Asn Gln Leu Gly
         170                 175                 180

 cat att ttt acc aat gat gaa gat gtc att gcc ctg gtg agc cag gtc      628
 His Ile Phe Thr Asn Asp Glu Asp Val Ile Ala Leu Val Ser Gln Val
     185                 190                 195

 ttg ccg gtt tat agt gtc ttt cac gtg ttt gag gcc atc tgt tgt gtc      676
 Leu Pro Val Tyr Ser Val Phe His Val Phe Glu Ala Ile Cys Cys Val
 200                 205                 210                 215

 tat ggc gga gtt ctg aga gga act ggg aag cag gcc ttt ggt gcc gct      724
 Tyr Gly Gly Val Leu Arg Gly Thr Gly Lys Gln Ala Phe Gly Ala Ala
                 220                 225                 230

 gtg aat gcc atc aca tat tac atc atc ggc cta cca ctg ggc atc ctt      772
 Val Asn Ala Ile Thr Tyr Tyr Ile Ile Gly Leu Pro Leu Gly Ile Leu
             235                 240                 245

 ctg acc ttt gtg gtc aga atg aga atc atg ggc ctc tgg ctg ggc atg      820
 Leu Thr Phe Val Val Arg Met Arg Ile Met Gly Leu Trp Leu Gly Met
         250                 255                 260

 ctg gcc tgt gtc ttc ctg gca act gct gcc ttt gtt gct tat act gcc      868
 Leu Ala Cys Val Phe Leu Ala Thr Ala Ala Phe Val Ala Tyr Thr Ala
     265                 270                 275

 cgg ctg gac tgg aag ctt gct gca gag gag gct aag aaa cat tca ggc      916
 Arg Leu Asp Trp Lys Leu Ala Ala Glu Glu Ala Lys Lys His Ser Gly
 280                 285                 290                 295

 cgg cag cag cag cag aga gca gag agc act gca acc aga cct ggg cct      964
 Arg Gln Gln Gln Gln Arg Ala Glu Ser Thr Ala Thr Arg Pro Gly Pro
                 300                 305                 310

 gag aaa gca gtc cta tct tca gtg gct aca ggc agt tcc cct ggc att     1012
 Glu Lys Ala Val Leu Ser Ser Val Ala Thr Gly Ser Ser Pro Gly Ile
             315                 320                 325

 acc ttg aca acg tat tca agg tct gag tgc cac gtg gac ttc ttc agg     1060
 Thr Leu Thr Thr Tyr Ser Arg Ser Glu Cys His Val Asp Phe Phe Arg
         330                 335                 340

 act cca gag gag gcc cac gcc ctt tca gct cct acc agc aga cta tca     1108
 Thr Pro Glu Glu Ala His Ala Leu Ser Ala Pro Thr Ser Arg Leu Ser
     345                 350                 355

 gtg aaa cag ctg gtc atc cgc cgt ggg gct gct ctg ggg gcg gcg tca     1156
 Val Lys Gln Leu Val Ile Arg Arg Gly Ala Ala Leu Gly Ala Ala Ser
 360                 365                 370                 375

 gcc aca ctg atg gtg ggg ctc acg gtc agg atc cta gcc acc agg cac     1204
 Ala Thr Leu Met Val Gly Leu Thr Val Arg Ile Leu Ala Thr Arg His
                 380                 385                 390

 tag caaa gaagcttgga aatagaaagc caggagtggc tgtccccagt atgcaaacac     1261
 






      <210> 153
      <211> 2024
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (778)..(1104)

      <400> 153
 cagttcccat ccctgcgcca ctgctccgtg aagaaggttg gagggggttg gggtggttga     60

 ggctaagttg ggatctagga gaggagaacc agattctatc ctcatctttt tttggttctt    120

 tggtccaaac ccaaaagaaa ctgacatgcc ctcccttctc cctggatcta cctggaggga    180

 agagtggagg tggattccga gtggtgacag gacgctgacc gtggagctta agccactgcc    240

 tctccctctg gtcccacaaa tgggcgcccc cccctcccca tgcaggtggt gtcgggccct    300

 tcttgctgcc ctgccccaag ttgggggtca gtgctgcctg tccccatgct taacataccc    360

 gcctagctgc tgtcacattt ttcttgtttt gtccttttat ttttttctaa taacctaaaa    420

 actggcaaaa tagttctgca ggttgaagcc atgtctacat gaaagtcctc agtaagtgtt    480

 agagggaaca gggcggagat atccttatgc cacccccgct ggaggatgtg ggcagcttag    540

 ggccctggag gcggtgcggc agggaagagg ggtgcagagg ctgtggctgg tgagccggtc    600

 aggcacacaa ggggcccttg gagcgtggac tggttggttt tgccattttg ttgtgtgtat    660

 gctgcttttc ttttctaacc aagaggctgg ttttggcatc tctgtcccat tccctgggat    720

 ctggtggtca gccctaggat aaaaagccag ggctggagaa caagaaaggg ccaggag       777                                                                 
 atg gaa ttc ctt cag gcc ggc acc cac acc cta gga cat gta agc cct      825
 Met Glu Phe Leu Gln Ala Gly Thr His Thr Leu Gly His Val Ser Pro
   1               5                  10                  15

 cat gtc caa ggg agc ctc atg cag ata gta gga aat cag gtc tgg aaa      873
 His Val Gln Gly Ser Leu Met Gln Ile Val Gly Asn Gln Val Trp Lys
              20                  25                  30

 ttt aaa aat aaa agg cat gag act aag gct atc tgc ttc cct tat gcc      921
 Phe Lys Asn Lys Arg His Glu Thr Lys Ala Ile Cys Phe Pro Tyr Ala
          35                  40                  45

 ctg act gga gag ggg agg gag gag agg caa ggc cca cag agg gca tcc      969
 Leu Thr Gly Glu Gly Arg Glu Glu Arg Gln Gly Pro Gln Arg Ala Ser
      50                  55                  60

 cag cta ggc ctt ggg atg gct gca gtg agg aga aat ccc ggg aac tgt     1017
 Gln Leu Gly Leu Gly Met Ala Ala Val Arg Arg Asn Pro Gly Asn Cys
  65                  70                  75                  80

 att gac aca aag att ctt att gca ctt gta ttt ttt gta tta aag ttt     1065
 Ile Asp Thr Lys Ile Leu Ile Ala Leu Val Phe Phe Val Leu Lys Phe
                  85                  90                  95

 gca tgg ttt cta ata aag gat tca aac ata agt ttg tag tgaaatggcc      1114
 Ala Trp Phe Leu Ile Lys Asp Ser Asn Ile Ser Leu 
             100                 105

 tgggagattc caagggcttc tctggagggg gattggctgc agtgtagatt tgcctctgag   1174

 gaggctgccc cagacttggc ctcctcatgc cccctcctga cctctgccct tctctggtcc   1234

 tggcatccct ggagaaggta ggggtcttga cctaagttta gatttgatct ccatgtgcag   1294

 ggaggctgtc ctgggcctga caggtcctcc ccctttctga ggtagcagtg ccttgtggag   1354

 gtttgacacc atgtccctag ctccccaagc acacaccagg aaactgcagg ggctcacgga   1414

 ggaagtgctg cctgggccag ggggaccagc tttcctccgt agagaccatg tgcagaacac   1474

 ttctgctgtg ccaagaacat gagggagcca gtgttttgtc agcaggaaga aagggcctgc   1534

 tgggatgaaa gtgggaagga aacagggttg ggtagtcagg agacacctca ggggcaacag   1594

 cacaggccca gagtacctgc tgcctccact gcgtctgtcc tggggtcatg aggatgctga   1654

 ggttgacgac aggttccagg tcctttcact cctttggcca aaggttgggg gtaggtggcc   1714

 caagtggcgt gctctctagg tagacaacag gagtggtcag agttccctca aagaaggatc   1774

 ctccactcca gagcacctga gaaggccggg accagaggcc ctgtgtgatg tgtactccgc   1834

 agctgtttgg ggtgggacat ttctgtactt ctcgatttgc ttatggctca gccattacct   1894

 gtgtcagtcc atgattctgt tgtaacagtt ttaagagtaa ataaataaag ctgcctgatg   1954

 tcccatcacg ataaaaaata atacatggtt tgacactttg gcctattctt ctagtaaaat   2014

 tattctttgg                                                          2024




      <210> 154
      <211> 2009
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (253)..(1944)

      <400> 154
 cttactggat gtcactctcg ggcttgccga cctaattttc actgacagca aactttatat     60

 tcctttggag tatcgttcta tttctctagc cattgcctta ttttttctca tggatgttct    120

 tcttcgagta tttgtaaaag ggtgttggag cgggccggag agaagtagag tgggctgcga    180

 ggagaaggaa acaggccttt cggaggctcc tcatccctcg gaggtcatcc cttactccag    240

 caagagtgag cc    atg gag cta cgt gtg ggg aac aag tac cgc ctg gga     288
                  Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly
                    1               5                  10

 cgg aag atc ggg agc ggg tcc ttc gga gat atc tac ctg ggt gcc aac      336
 Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn
          15                  20                  25

 atc gcc tct ggt gag gac gtc gcc atc aag ctg gag tgt gtg aag aca      384
 Ile Ala Ser Gly Glu Asp Val Ala Ile Lys Leu Glu Cys Val Lys Thr
      30                  35                  40

 aag cac ccc cag ctg cac atc gag agc aag ttc tac aag atg atg cag      432
 Lys His Pro Gln Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln
  45                  50                  55                  60

 ggt ggc gtg ggg atc ccg tcc atc aag tgg tgc gga gct gag ggc gac      480
 Gly Gly Val Gly Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp
                  65                  70                  75

 tac aac gtg atg gtc atg gag ctg ctg ggg cct agc ctc gag gac ctg      528
 Tyr Asn Val Met Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu
              80                  85                  90

 ttc aac ttc tgt tcc cgc aaa ttc agc ctc aag acg gtg ctg ctc ttg      576
 Phe Asn Phe Cys Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu
          95                 100                 105

 gcc gac cag atg atc agc cgc atc gag tat atc cac tcc aag aac ttc      624
 Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe
     110                 115                 120

 atc cac cgg gac gtc aag ccc gac aac ttc ctc atg ggg ctg ggg aag      672
 Ile His Arg Asp Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys
 125                 130                 135                 140

 aag ggc aac ctg gtc tac atc atc gac ttc ggc ctg gcc aag aag tac      720
 Lys Gly Asn Leu Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr
                 145                 150                 155

 cgg gac gcc cgc acc cac cag cac att ccc tac cgg gaa aac aag aac      768
 Arg Asp Ala Arg Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn
             160                 165                 170

 ctg acc ggc acg gcc cgc tac gct tcc atc aac acg cac ctg ggc att      816
 Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile
         175                 180                 185

 gag caa agc cgt cga gat gac ctg gag agc ctg ggc tac gtg ctc atg      864
 Glu Gln Ser Arg Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met
     190                 195                 200

 tac ttc aac ctg ggc tcc ctg ccc tgg cag ggg ctc aaa gca gcc acc      912
 Tyr Phe Asn Leu Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr
 205                 210                 215                 220

 aag cgc cag aag tat gaa cgg atc agc gag aag aag atg tca acg ccc      960
 Lys Arg Gln Lys Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro
                 225                 230                 235

 atc gag gtc ctc tgc aaa ggc tat ccc tcc gaa ttc tca aca tac ctc     1008
 Ile Glu Val Leu Cys Lys Gly Tyr Pro Ser Glu Phe Ser Thr Tyr Leu
             240                 245                 250

 aac ttc tgc cgc tcc ctg cgg ttt gac gac aag ccc gac tac tct tac     1056
 Asn Phe Cys Arg Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr
         255                 260                 265

 cta cgt cag ctc ttc cgc aac ctc ttc cac cgg cag ggc ttc tcc tat     1104
 Leu Arg Gln Leu Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr
     270                 275                 280

 gac tac gtc ttt gac tgg aac atg ctg aaa ttc gtg agt cac ctg gag     1152
 Asp Tyr Val Phe Asp Trp Asn Met Leu Lys Phe Val Ser His Leu Glu
 285                 290                 295                 300

 gcc aag gcg ggc ttg ggg gac tgg atg ggg aag gcc ctg act cag agg     1200
 Ala Lys Ala Gly Leu Gly Asp Trp Met Gly Lys Ala Leu Thr Gln Arg
                 305                 310                 315

 gcc aga gtg agc tgg tgg cgg gag ggg ctc ccg aca gac ggg agg tac     1248
 Ala Arg Val Ser Trp Trp Arg Glu Gly Leu Pro Thr Asp Gly Arg Tyr
             320                 325                 330

 gag ctg gac agt gtg gtt gac ctc act ggg gtc cca gag ccc tcc agc     1296
 Glu Leu Asp Ser Val Val Asp Leu Thr Gly Val Pro Glu Pro Ser Ser
         335                 340                 345

 ctc atc cgt gct gac agc ttg tgc cac cat ggg cag cag ggc cca ggc     1344
 Leu Ile Arg Ala Asp Ser Leu Cys His His Gly Gln Gln Gly Pro Gly
     350                 355                 360

 agg gcg ctg tct ccc gtc gga aca agg agg atc tgg ctt cac ctg ggg     1392
 Arg Ala Leu Ser Pro Val Gly Thr Arg Arg Ile Trp Leu His Leu Gly
 365                 370                 375                 380

 tcc ctc ctg ggt gcc cgc agc agg gca tgg gtg gtg ctg gcg gcg ccc     1440
 Ser Leu Leu Gly Ala Arg Ser Arg Ala Trp Val Val Leu Ala Ala Pro
                 385                 390                 395

 cct gct gcc ctg att gct gcc tac acc gtc ctg ctg ctc ctg ttc tgc     1488
 Pro Ala Ala Leu Ile Ala Ala Tyr Thr Val Leu Leu Leu Leu Phe Cys
             400                 405                 410

 aca tcc cag gtg gct acc tgc acc atg gcc cct cgg gcc agc ctg gac     1536
 Thr Ser Gln Val Ala Thr Cys Thr Met Ala Pro Arg Ala Ser Leu Asp
         415                 420                 425

 cca gtc atg gtg ctt gct ttc ttc ttg gtc atg ggc ccc tgg ggt gca     1584
 Pro Val Met Val Leu Ala Phe Phe Leu Val Met Gly Pro Trp Gly Ala
     430                 435                 440

 gcc cgg aat ccc gag gat gtg gac cgg gag cgg cga gaa cac gaa cgc     1632
 Ala Arg Asn Pro Glu Asp Val Asp Arg Glu Arg Arg Glu His Glu Arg
 445                 450                 455                 460

 gag gag agg atg ggg cag cta cgg ggg tcc gcg acc cga gcc ctg ccc     1680
 Glu Glu Arg Met Gly Gln Leu Arg Gly Ser Ala Thr Arg Ala Leu Pro
                 465                 470                 475

 cct ggc cca ccc acg ggg gcc act gcc aac cgg ctc cgc agt gcc gcc     1728
 Pro Gly Pro Pro Thr Gly Ala Thr Ala Asn Arg Leu Arg Ser Ala Ala
             480                 485                 490

 gag ccc gtg gct tcc acg cca gcc tcc cgc atc cag ccg gct ggc aat     1776
 Glu Pro Val Ala Ser Thr Pro Ala Ser Arg Ile Gln Pro Ala Gly Asn
         495                 500                 505

 act tct ccc aga gcg atc tcg cgg gtc gac cgg gag agg aag gtg agt     1824
 Thr Ser Pro Arg Ala Ile Ser Arg Val Asp Arg Glu Arg Lys Val Ser
     510                 515                 520

 atg agg ctg cac agg ggt gcg ccc gcc aac gtc tcc tcc tca gac ctc     1872
 Met Arg Leu His Arg Gly Ala Pro Ala Asn Val Ser Ser Ser Asp Leu
 525                 530                 535                 540

 act ggg cgg caa gag gtc tcc cgg atc cca gcc tca cag aca agt gtg     1920
 Thr Gly Arg Gln Glu Val Ser Arg Ile Pro Ala Ser Gln Thr Ser Val
                 545                 550                 555

 cca ttt gac cat ctc ggg aag tga ggagagcccc cattggacca gtgtttgctt    1974
 Pro Phe Asp His Leu Gly Lys 
             560

 agtgtcttca ctgtattttc tttaaaaaaa aaaaa                              2009




      <210> 155
      <211> 3762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(1525)

      <400> 155
 ggtctgggct cggggcgcgg cggcagtcag ctct    atg ttt cgc ggt ctt aac      52
                                          Met Phe Arg Gly Leu Asn
                                            1               5

 ctc tcc tct ggc cga gtc ctt gca aga agt gaa tta ccc gac cct gca      100
 Leu Ser Ser Gly Arg Val Leu Ala Arg Ser Glu Leu Pro Asp Pro Ala
              10                  15                  20

 aaa cac tta cta ttt tgg agt tta aag tat gtc atc atg gca aag ttt      148
 Lys His Leu Leu Phe Trp Ser Leu Lys Tyr Val Ile Met Ala Lys Phe
          25                  30                  35

 cgg aga agg act tgc atc att ttg gca ctt ttt att cta ttt att ttc      196
 Arg Arg Arg Thr Cys Ile Ile Leu Ala Leu Phe Ile Leu Phe Ile Phe
      40                  45                  50

 tct ctg atg atg ggt tta aaa atg ctg aga cca aat aca gct act ttt      244
 Ser Leu Met Met Gly Leu Lys Met Leu Arg Pro Asn Thr Ala Thr Phe
  55                  60                  65                  70

 gga gct cct ttt gga ctt gac ctt ctt cca gaa ctt cat caa cga act      292
 Gly Ala Pro Phe Gly Leu Asp Leu Leu Pro Glu Leu His Gln Arg Thr
                  75                  80                  85

 att cat ttg ggg aaa aat ttt gat ttc caa aag agt gac aga atc aac      340
 Ile His Leu Gly Lys Asn Phe Asp Phe Gln Lys Ser Asp Arg Ile Asn
              90                  95                 100

 agt gaa aca aat acc aag aat tta aaa agt gtt gaa atc act atg aaa      388
 Ser Glu Thr Asn Thr Lys Asn Leu Lys Ser Val Glu Ile Thr Met Lys
         105                 110                 115

 cct tcc aaa gcc tct gaa ctt aac ttg gat gaa cta cca cct ctg aac      436
 Pro Ser Lys Ala Ser Glu Leu Asn Leu Asp Glu Leu Pro Pro Leu Asn
     120                 125                 130

 aat tat cta cat gta ttt tat tac agt tgg tat gga aat cca caa ttt      484
 Asn Tyr Leu His Val Phe Tyr Tyr Ser Trp Tyr Gly Asn Pro Gln Phe
 135                 140                 145                 150

 gat ggt aaa tat ata cat tgg aat cat cca gtg tta gag cat tgg gac      532
 Asp Gly Lys Tyr Ile His Trp Asn His Pro Val Leu Glu His Trp Asp
                 155                 160                 165

 cct aga ata gcc aag aat tat cca caa ggg aga cac aac cct cca gat      580
 Pro Arg Ile Ala Lys Asn Tyr Pro Gln Gly Arg His Asn Pro Pro Asp
             170                 175                 180

 gac att ggc tcc agc ttt tat cct gaa ttg gga agt tac agt tct cgg      628
 Asp Ile Gly Ser Ser Phe Tyr Pro Glu Leu Gly Ser Tyr Ser Ser Arg
         185                 190                 195

 gat cct tct gtc ata gaa act cac atg aga caa atg cgc tca gct tca      676
 Asp Pro Ser Val Ile Glu Thr His Met Arg Gln Met Arg Ser Ala Ser
     200                 205                 210

 att ggt gta cta gcc ctc tct tgg tac cca cct gat gta aat gat gaa      724
 Ile Gly Val Leu Ala Leu Ser Trp Tyr Pro Pro Asp Val Asn Asp Glu
 215                 220                 225                 230

 aat gga gaa cct act gat aac ttg gta ccc act att ttg gat aaa gct      772
 Asn Gly Glu Pro Thr Asp Asn Leu Val Pro Thr Ile Leu Asp Lys Ala
                 235                 240                 245

 cat aaa tat aac cta aag gtt act ttt cac ata gaa cca tat agc aat      820
 His Lys Tyr Asn Leu Lys Val Thr Phe His Ile Glu Pro Tyr Ser Asn
             250                 255                 260

 cga gat gat caa aac atg tac aaa aat gtc aag tat att ata gac aaa      868
 Arg Asp Asp Gln Asn Met Tyr Lys Asn Val Lys Tyr Ile Ile Asp Lys
         265                 270                 275

 tat gga aat cat ccg gcc ttt tac agg tac aag acg aag act ggc aat      916
 Tyr Gly Asn His Pro Ala Phe Tyr Arg Tyr Lys Thr Lys Thr Gly Asn
     280                 285                 290

 gct ctt cct atg ttt tat gtc tat gat tcc tat att acc aag cct gaa      964
 Ala Leu Pro Met Phe Tyr Val Tyr Asp Ser Tyr Ile Thr Lys Pro Glu
 295                 300                 305                 310

 aaa tgg gcc aat ctg tta acc acc tca ggg tct cgg agt att cgc aat     1012
 Lys Trp Ala Asn Leu Leu Thr Thr Ser Gly Ser Arg Ser Ile Arg Asn
                 315                 320                 325

 tct cct tat gat gga ctg ttt att gcc ctt ctg gta gaa gaa aaa cat     1060
 Ser Pro Tyr Asp Gly Leu Phe Ile Ala Leu Leu Val Glu Glu Lys His
             330                 335                 340

 aag tat gat att ctt caa agt ggt ttt gat gga att tac aca tat ttt     1108
 Lys Tyr Asp Ile Leu Gln Ser Gly Phe Asp Gly Ile Tyr Thr Tyr Phe
         345                 350                 355

 gcc aca aat ggc ttt act tat ggc tca tca cat cag aat tgg gct agc     1156
 Ala Thr Asn Gly Phe Thr Tyr Gly Ser Ser His Gln Asn Trp Ala Ser
     360                 365                 370

 cta aaa tta ttt tgt gat aaa tac aac tta ata ttt atc cca agt gtg     1204
 Leu Lys Leu Phe Cys Asp Lys Tyr Asn Leu Ile Phe Ile Pro Ser Val
 375                 380                 385                 390

 ggc cca gga tac ata gat acc agc atc cgt cca tgg aac acg caa aac     1252
 Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg Pro Trp Asn Thr Gln Asn
                 395                 400                 405

 act cgg aac cga atc aat ggg aag tat tat gaa att ggt ctg agt gcc     1300
 Thr Arg Asn Arg Ile Asn Gly Lys Tyr Tyr Glu Ile Gly Leu Ser Ala
             410                 415                 420

 gca ctt cag aca cgc ccc agc tta att tct atc acc tct ttt aat gag     1348
 Ala Leu Gln Thr Arg Pro Ser Leu Ile Ser Ile Thr Ser Phe Asn Glu
         425                 430                 435

 tgg cat gaa gga act cag att gaa aaa gct gtt ccc aaa aga acc agt     1396
 Trp His Glu Gly Thr Gln Ile Glu Lys Ala Val Pro Lys Arg Thr Ser
     440                 445                 450

 aat aca gtg tac cta gat tac cgt cct cat aaa cca ggt ctt tac cta     1444
 Asn Thr Val Tyr Leu Asp Tyr Arg Pro His Lys Pro Gly Leu Tyr Leu
 455                 460                 465                 470

 gaa ctg act cgc aag tgg tct gaa aaa tac agt aag gaa aga gca act     1492
 Glu Leu Thr Arg Lys Trp Ser Glu Lys Tyr Ser Lys Glu Arg Ala Thr
                 475                 480                 485

 tat gca tta gat cgc cag ctg cct gtt tct taa tgcattga ttaaagttta     1543
 Tyr Ala Leu Asp Arg Gln Leu Pro Val Ser 
             490                 495

 atagttatca aaatcaccta atttttaaaa atagctttcg ttttgagttc tggaaagaaa   1603

 actgtcaaaa tcagtatata ctattagtta tatttaaaaa tattttttta aattctttac   1663

 agataatatt atacttgtta cccttcacaa taccacatga gaaaatatct gagacaaaat   1723

 gtatacaaat atattcctta tggcataatt tattgcattt ctgactgaaa tcaaaattct   1783

 gatttgatgg caattgaatt ttcattttac aatagataaa tgcttgtgtt acctaaagca   1843

 cttagcacac agttaaatta tatttacatc ctagacccaa ataaatagga ttgtgtgtat   1903

 atttgggata tctattgaag aaaaaaagaa aaccccttaa agataatgta catgcttcat   1963

 gtcatgtctt taaaataatt taatcaactt tattgtctta gtatttagac tctggataac   2023

 tctacaataa tgaggaaatt cttaagaata acaaaatcac tgtaccttcc tctcaatttt   2083

 gctgtgaacc tgaaatggct ttaaattaat actcttattt tttatttaat ttaattacat   2143

 aaattaaacc ttaccatgac caaattgtgt taggaaggcc tgctatctac agcacagtgt   2203

 gtcatttgca gatttgtggt tacctatacc acgctaggtg ttttgacatg tttagtgttt   2263

 ctgctttaca gtgctgaatt ccatatttta gaagctatga aagtcctttt atgaaaaagt   2323

 tactgattgc ttctcagtta ttaggaaaac agttgtttca caattattat gtagatatga   2383

 tgcccaaata tcatttttag tatatcttgt cgatctttaa gttgttacta ttgtgttatt   2443

 catgtcttta aatcagatac caaatatttt ttaggaaaga aaaatgttat tactgtcatt   2503

 aggttgtctt ttaatacttt aagttatttt gacgaaaagt aatagagaaa atttacttag   2563

 cattttagat tctagagaca tggaaatgaa aattatttta tgtctagagt aggtcctgaa   2623

 gtttggcttt acattaagtt tagcactgta tcagaatgaa gaaactaata ttttacataa   2683

 aaactaatac tttcaatttt ttatatagta atatccccat tttgtaaatg ttagactttt   2743

 atcatacctg taagttaaaa tacttgttat caataacttg tcatattgtg acaaattgat   2803

 cacttgtgta cgaaaaataa atctccttaa aaactaaata aaatgcactg tattcttaca   2863

 gttaatgttt ataactatag taaaaaatta atatatatcc tattacataa atgttatttc   2923

 ttaggtgttc cattaagaag agcaatagaa taatgctaaa aaataatgcc tataaatctt   2983

 cagagtataa agacatccat tcagaaacaa aaattagcac taaatttttt ataaaataga   3043

 ccagatgaca aaatttattt tatttttaaa cagtggtttt gacacaaatt atgttattga   3103

 aaagcattat taatgtttaa tttatttaaa attttggaat ttgccatttc tcagacaatg   3163

 atcaggcctt aggaaattaa tacagtagta gtaatcattt tctaggggaa aataaaagaa   3223

 taaatcacta tactgatatt ttgatataag caagcactta catggtaatc actatataga   3283

 tccaacctgt ggattttctt cttatgtcca tttaactaga atatattatt ttaggtataa   3343

 tttacaaatg tcacacctaa taatctttta taatatacca tatttcatta aagttttgtt   3403

 agagaagtat ctaccacaga ggagtttttg tcattgtgta cgttgtgtat ttgaacccac   3463

 catgacagaa agtaaatttt aggaaatagt tatgagatta agggaaaatc tataaaaaca   3523

 aggttagcat attctcaaca cagataccac cactttcttt ttcccattat agacatggtg   3583

 aatccacaca gcatacttca tctctgagct ttgttgtgat tcctcaacac attaccctaa   3643

 ccagccagca gtaacagatt tcagagtaag ataaagcaga ttctgtcttc attgcaaaaa   3703

 gttattctca atggaagaat ggcatctgat ctcataatta ctagtttata ttaatatag    3762




      <210> 156
      <211> 2035
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1046)..(1807)

      <400> 156
 atggagatta ttatctctgt tctacagaga agaaaaagtg actttcccag gatcactcag     60

 tgtgtggtgg agcccaaatg ggagctcggg tctttgacat gcagactggc tctggccacc    120

 aaggccctct ctggcatcat cctggtggta gtgggcataa aggctgaggg gaagggagca    180

 gctgatcctg aaacagcagt ggatccctgg gagagcagca cagataaaga tccaggcaat    240

 aatgatgctt cctcctcttg gacagccttt tacagttctg gccatggaac ttcagagaag    300

 aagtccttga tggtttccgt ggaatcgatt cccagtgggg gaaatgatga gtcaaggtta    360

 catacagttt acggcctctg ctagtaacac gcactgagta gggggacggc atggatgcag    420

 ccttctgtct ttacgaaaac catgagtctg aagacatggg tcccatgtca ccattaacta    480

 gctgggtgac tttggatcaa ctcttcaaat tattcgaatg acccatatga gaaacagaga    540

 aaagccaagt atttctggtt gaaacggaga agctgggctg gagtgcgcct ccctccaact    600

 ccccgcttta actccctaag gaagctctct ggccttggct ccaagcaggt gtgctcaaga    660

 ggctgccgac tgggccacct ggcagcccca ggtgctgcgt gcatgctgcc atggagacag    720

 gcccctgggt tggtggcaag aaggcagtct cccaaagctt tgccgattca ggggagggag    780

 caactggagc ctcaggccct ccagagtagt ctgcctgacc accctggagc ccacagaagc    840

 ccaggtgcgt gccctgaagg tttcccagga caaagggagg gaggaggagc cagggtaggc    900

 agaggatggg gaagaggctc tggaagggga agaggctctg gaaggggaag aggctctgga    960

 agggctgatc tggggactgg ggcagggaag cttctgcaag gcttccagga cgtctcccgc   1020

 gaggcctccc cgtgtgtggc tgagg  atg gct gag cag cag ggc cgg gag ctt    1072
                              Met Ala Glu Gln Gln Gly Arg Glu Leu
                                1               5

 gag gct gag tgc ccc gtc tgc tgg aac ccc ttc aac aac acg ttc cat     1120
 Glu Ala Glu Cys Pro Val Cys Trp Asn Pro Phe Asn Asn Thr Phe His
  10                  15                  20                  25

 acc ccc aaa atg ctg gat tgc tgc cac tcc ttc tgc gtg gaa tgt ctg     1168
 Thr Pro Lys Met Leu Asp Cys Cys His Ser Phe Cys Val Glu Cys Leu
                  30                  35                  40

 gcc cac ctc agc ctt gtg act cca gcc cgg cgc cgc ctg ctg tgc cca     1216
 Ala His Leu Ser Leu Val Thr Pro Ala Arg Arg Arg Leu Leu Cys Pro
              45                  50                  55

 ctc tgt cgc cag ccc aca gtg ctg gcc tca ggg cag cct gtc act gac     1264
 Leu Cys Arg Gln Pro Thr Val Leu Ala Ser Gly Gln Pro Val Thr Asp
          60                  65                  70

 ttg ccc acg gac act gcc atg ctc acc ctg ctc cgc ctg gag ccc cac     1312
 Leu Pro Thr Asp Thr Ala Met Leu Thr Leu Leu Arg Leu Glu Pro His
      75                  80                  85

 cat gtc atc ctg gaa ggc cat cag ctg tgc ctc aag gac cag ccc aag     1360
 His Val Ile Leu Glu Gly His Gln Leu Cys Leu Lys Asp Gln Pro Lys
  90                  95                 100                 105

 agc cgc tac ttc ctg cgc cag cct cga gtc tac acg ctg gac ctt ggc     1408
 Ser Arg Tyr Phe Leu Arg Gln Pro Arg Val Tyr Thr Leu Asp Leu Gly
                 110                 115                 120

 ccc cag cct tgg ggg cca gac tgg gcc gcc ccc aga cac ggc ctc tgc     1456
 Pro Gln Pro Trp Gly Pro Asp Trp Ala Ala Pro Arg His Gly Leu Cys
             125                 130                 135

 cac cgt gtc tac gcc cat cct cat ccc cag cca cca ctc ttt gag gga     1504
 His Arg Val Tyr Ala His Pro His Pro Gln Pro Pro Leu Phe Glu Gly
         140                 145                 150

 gtg ttt ccg caa ccc tca gtt ccg cat ctt tgc cta cct gat ggc cgt     1552
 Val Phe Pro Gln Pro Ser Val Pro His Leu Cys Leu Pro Asp Gly Arg
     155                 160                 165

 cat cct cag tgt cac tct gtt gct cat att ctc cat ctt ttg gac caa     1600
 His Pro Gln Cys His Ser Val Ala His Ile Leu His Leu Leu Asp Gln
 170                 175                 180                 185

 gca gtt cct ttg ggg tgt ggg gtg agt gct gtt ccc aga caa gaa acc     1648
 Ala Val Pro Leu Gly Cys Gly Val Ser Ala Val Pro Arg Gln Glu Thr
                 190                 195                 200

 aaa cct ttt tcg gtt gct gct ggg tat ggt gac tac gga gcc tca ttt     1696
 Lys Pro Phe Ser Val Ala Ala Gly Tyr Gly Asp Tyr Gly Ala Ser Phe
             205                 210                 215

 ggt att gtc ttc ctt tgt agt gtt gtt tat ttt aca atc cag gga ttg     1744
 Gly Ile Val Phe Leu Cys Ser Val Val Tyr Phe Thr Ile Gln Gly Leu
         220                 225                 230

 ttc agg cca tgt gtt tgc ttc tgg gaa caa ttt aaa aaa aaa aca aaa     1792
 Phe Arg Pro Cys Val Cys Phe Trp Glu Gln Phe Lys Lys Lys Thr Lys
     235                 240                 245

 aaa cga aaa gct tga aggactggga gatgtggagc gacctccggg tgtgagtgtg     1847
 Lys Arg Lys Ala 
 250

 gcgtcatgga agggcagaga agcggttctg accacagagc tccacagcaa gttgtgccaa   1907

 agggctgcac agtggtatcc aggaacctga ctagccgaaa tagcaagttg catttctcac   1967

 tggagctgct tcaaaatcag tgcatatttt tttgagttgc tcttttacta tgggttgcta   2027

 aaaaaaaa                                                            2035




      <210> 157
      <211> 1222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (378)..(734)

      <400> 157
 tgatccgcag cgctgcgacg ggaccgcgcg attcctctcc cacgcatctg gcccgcgttc     60

 ctgggcctcg gcaccggatc ccggcggggg tgtggaccca gggcccactc tccccggcgc    120

 ggccagggcc ccccagcgtg cgagcgccta ggggatgccg agctgctcaa gatgaggagg    180

 tgcgcggggc cggggcggag cagtcgcgtt ccccgcgtgt gagcccccac ccatccctgg    240

 cgccagcgct tccccgacca ctcgggttcg gctatgcggg agccgtgagg aggaggcttg    300

 cagtcgtgga cctgagacct cgggaggtca tgctgtcttg cttttaagtg gcttggggaa    360

 agtgaagaaa ccccaaa   atg gag gac ttt gct acc agg acc tac ggc acc     410
                      Met Glu Asp Phe Ala Thr Arg Thr Tyr Gly Thr
                        1               5                  10

 agt ggc ctg gac aac aga cct ctg ttt ggg gag acg tcc gcc aag gat      458
 Ser Gly Leu Asp Asn Arg Pro Leu Phe Gly Glu Thr Ser Ala Lys Asp
              15                  20                  25

 cga atc atc aat tta gtt gtt ggc agc tta aca tcc tta ttg att cta      506
 Arg Ile Ile Asn Leu Val Val Gly Ser Leu Thr Ser Leu Leu Ile Leu
          30                  35                  40

 gta acg ctg ata agt gct ttt gtt ttc cct caa cta cct cca aaa ccg      554
 Val Thr Leu Ile Ser Ala Phe Val Phe Pro Gln Leu Pro Pro Lys Pro
      45                  50                  55

 ttg aat ata ttc ttt gct gtc tgc atc tct ttg agt agt att act gcc      602
 Leu Asn Ile Phe Phe Ala Val Cys Ile Ser Leu Ser Ser Ile Thr Ala
  60                  65                  70                  75

 tgc ata ctt atc tac tgg tat cga caa gga gac tta gaa ccg aaa ttt      650
 Cys Ile Leu Ile Tyr Trp Tyr Arg Gln Gly Asp Leu Glu Pro Lys Phe
                  80                  85                  90

 aga aag cta att tac tat atc ata ttt tct atc atc atg ttg tgt ata      698
 Arg Lys Leu Ile Tyr Tyr Ile Ile Phe Ser Ile Ile Met Leu Cys Ile
              95                 100                 105

 tgt gca aac ctg tac ttc cat gat gtg gga agg tga ggct gccaaggaga      748
 Cys Ala Asn Leu Tyr Phe His Asp Val Gly Arg 
         110                 115

 agtacttacc aggactcttc aaaatgatac attaggacag tgagtaattt ttggataagg    808

 tatgctgaag aatctcctgc agaagtctga tacatgattt tcatgttaat tgtaaatgtt    868

 aattccctct tgcaagggag acatatccta gatcactttg ctttttcttt aaggagctga    928

 tgttgcacct aaacattcca acccttaaag ctaaaacagc acaaaaaaat ttcacttttg    988

 aaatgaaatt tttataattg tatggcaaaa ggctatgtaa aaacaaatct tgcatcttaa   1048

 gacaaatatt cttttatttc tgttaaactg aatatacaat tgttccctag gcaaccaact   1108

 tttgcttata actacaattt aatttcacgt tgacaaaaca cagtgaaaag acaactttgt   1168

 gaagatctaa ttacaataat aaataaaata atttatacaa ggaaaaaaaa aaaa         1222




      <210> 158
      <211> 1756
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(1172)

      <400> 158
 ccaagcttgg cacgagggca gggcacagcc cctccgtgtc cctttgtctc tcctgtctga     60

 aggccagagc aggctgctag gcctggggcc accactggcc ctgggtgcta cacccagtgt    120

 gctgggtcac tgggaacttc ctgaagtggt gtcacctgaa ctgggccccc aaggatgggg    180

 tgcgggcagt accgcaggaa gaggagcagc ccctgtgaag attgagagct gccagaggct    240

 ctgtgattgg ctgcggcacg    atg acc cgc gca cgg att ggc tgc ttc ggg     290
                          Met Thr Arg Ala Arg Ile Gly Cys Phe Gly
                            1               5                  10

 ccg ggg ggc cgg gcc cgg ggg aca gaa tcc gcc ccc gaa cct tca aag      338
 Pro Gly Gly Arg Ala Arg Gly Thr Glu Ser Ala Pro Glu Pro Ser Lys
                  15                  20                  25

 agg gta ccc ccc ggc agg agc tgg cag acc cag gag gtg cga cag acc      386
 Arg Val Pro Pro Gly Arg Ser Trp Gln Thr Gln Glu Val Arg Gln Thr
              30                  35                  40

 cgc ggg gca aac gga ctg ggg cca aga gcc ggg agc gcg ggc gca aag      434
 Arg Gly Ala Asn Gly Leu Gly Pro Arg Ala Gly Ser Ala Gly Ala Lys
          45                  50                  55

 gca cca ggg ccc gcc cag ggc gcc gcg cag cac ggc ctt ggg ggt tct      482
 Ala Pro Gly Pro Ala Gln Gly Ala Ala Gln His Gly Leu Gly Gly Ser
      60                  65                  70

 gcg ggc ctt cgg gtg cgc gtc tcg cct cta gcc atg ggg tcc gca gcg      530
 Ala Gly Leu Arg Val Arg Val Ser Pro Leu Ala Met Gly Ser Ala Ala
  75                  80                  85                  90

 ttg gag atc ctg ggc ctg gtg ctg tgc ctg gtg ggc tgg ggg ggt ctg      578
 Leu Glu Ile Leu Gly Leu Val Leu Cys Leu Val Gly Trp Gly Gly Leu
                  95                 100                 105

 atc ctg gcg tgc ggg ctg ccc atg tgg cag gtg acc gcc ttc ctg gac      626
 Ile Leu Ala Cys Gly Leu Pro Met Trp Gln Val Thr Ala Phe Leu Asp
             110                 115                 120

 cac aac atc gtg acg gcg cag acc acc tgg aag ggg ctg tgg atg tcg      674
 His Asn Ile Val Thr Ala Gln Thr Thr Trp Lys Gly Leu Trp Met Ser
         125                 130                 135

 tgc gtg gtg cag agc acc ggg cac atg cag tgc aaa gtg tac gac tcg      722
 Cys Val Val Gln Ser Thr Gly His Met Gln Cys Lys Val Tyr Asp Ser
     140                 145                 150

 gtg ctg gct ctg agc acc gag gtg cag gcg gcg cgg gcg ctc acc gtg      770
 Val Leu Ala Leu Ser Thr Glu Val Gln Ala Ala Arg Ala Leu Thr Val
 155                 160                 165                 170

 agc gcc gtg ctg ctg gcg ttc gtt gcg ctc ttc gtg acc ctg gcg ggc      818
 Ser Ala Val Leu Leu Ala Phe Val Ala Leu Phe Val Thr Leu Ala Gly
                 175                 180                 185

 gcg cag tgc acc acc tgc gtg gcc ccg ggc ccg gcc aag gcg cgt gtg      866
 Ala Gln Cys Thr Thr Cys Val Ala Pro Gly Pro Ala Lys Ala Arg Val
             190                 195                 200

 gcc ctc acg gga ggc gtg ctc tac ctg ttt tgc ggg ctg ctg gcg ctc      914
 Ala Leu Thr Gly Gly Val Leu Tyr Leu Phe Cys Gly Leu Leu Ala Leu
         205                 210                 215

 gtg cca ctc tgc tgg ttc gcc aac att gtc gtc cgc gag ttt tac gac      962
 Val Pro Leu Cys Trp Phe Ala Asn Ile Val Val Arg Glu Phe Tyr Asp
     220                 225                 230

 ccg tct gtg ccc gtg tcg cag aag tac gag ctg ggc gca gcg ctg tac     1010
 Pro Ser Val Pro Val Ser Gln Lys Tyr Glu Leu Gly Ala Ala Leu Tyr
 235                 240                 245                 250

 atc ggc tgg gcg gcc acc gcg ctg ctc atg gta ggc ggc tgc ctc ttg     1058
 Ile Gly Trp Ala Ala Thr Ala Leu Leu Met Val Gly Gly Cys Leu Leu
                 255                 260                 265

 tgc tgc ggc gcc tgg gtc tgc acc ggc cgt ccc gac ctc agc ttc ccc     1106
 Cys Cys Gly Ala Trp Val Cys Thr Gly Arg Pro Asp Leu Ser Phe Pro
             270                 275                 280

 gtg aag tac tca gcg ccg cgg cgg ccc acg gcc acc ggc gac tac gac     1154
 Val Lys Tyr Ser Ala Pro Arg Arg Pro Thr Ala Thr Gly Asp Tyr Asp
         285                 290                 295

 aag aag aac tac gtc tga gggcgc tgggcacggc cgggcccctc ctgccagcca     1208
 Lys Lys Asn Tyr Val 
     300

 cgcctgcgag gcgttggata agcctgggga gccccgcatg gaccgcggct tccgccgggt   1268

 agcgcggcgc gcaggctcct cggaacgtcc ggctctgcgc cccgacgcgg ctcctggatc   1328

 cgctcctgcc tgcgcccgca gctgaccttc tcctgccact agcccggccc tgcccttaac   1388

 agacggaatg aagtttcctt ttctgtgcgc ggcgctgttt ccataggcag agcgggtgtc   1448

 agactgagga tttcgcttcc cctccaagac gctgggggtc ttggctgctg ccttacttcc   1508

 cagaggctcc tgctgacttc ggaggggcgg atgcagagcc cagggccccc accggaagat   1568

 gtgtacagct ggtctttact ccatcggcag ggcccgagcc cagggaccag tgacttggcc   1628

 tggacctccc ggtctcactc cagcatctcc ccaggcaagg cttgtgggca ccggagcttg   1688

 agagagggcg ggagtgggaa ggctaagaat ctgcttagta aatggtttga actctcaaaa   1748

 aaaaaaaa                                                            1756




      <210> 159
      <211> 1596
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (563)..(1351)

      <400> 159
 cccacgcgtc cgcccacgcg tccgcggacg cgtgggctct tccgtttctg tcgctgcagt     60

 cgtccgcggg taaggccctc cctagaccct ttatacctac tttacctttc ggaggtcaag    120

 acacctcctg ttgccgcctc ctcgcccaac acacaggcgc cccccgcacg ggtaccaagc    180

 ttgactaacg gcctctaggg gtgtgtggtg ggacttgaaa tcctccctta atgaagtcac    240

 accttctccg tccgcttcca cccggtcggc ccatggcaga gcccccatgt agcccaggaa    300

 tcggcttggc ccttcgggga ggtcagcgtc cttactatcc ccactctcca gtgcggcaca    360

 ttcgttcccc taggactccg gccggttgcc ggccccaggc ggtgcttctc cccaccaccg    420

 cccagctcag ctcagcccag cccagcccac tctgccctta gaggcccttc tccccaaaga    480

 cgcactccag aagtctcgcc ctcgtgcggc tgaggagcct gggatcccag acctgaacaa    540

 gtgaaacccc cgcccctgaa ga atg ggt aag acg ttt tcc cag ctg ggc tct     592
                          Met Gly Lys Thr Phe Ser Gln Leu Gly Ser
                            1               5                  10

 tgg cgg gag gat gag aac aag tca atc ctg tcc tcc aaa cca gcc att      640
 Trp Arg Glu Asp Glu Asn Lys Ser Ile Leu Ser Ser Lys Pro Ala Ile
                  15                  20                  25

 ggc agc aag gct gtc aac tac tcc agc acc ggt agc agc aag tct ttt      688
 Gly Ser Lys Ala Val Asn Tyr Ser Ser Thr Gly Ser Ser Lys Ser Phe
              30                  35                  40

 tgt tcc tgt gtg cct tgt gaa gga act gct gat gcc agc ttc gtg act      736
 Cys Ser Cys Val Pro Cys Glu Gly Thr Ala Asp Ala Ser Phe Val Thr
          45                  50                  55

 tgt ccc acc tgc cag ggc agt ggc aag att ccc caa gag ctg gag aag      784
 Cys Pro Thr Cys Gln Gly Ser Gly Lys Ile Pro Gln Glu Leu Glu Lys
      60                  65                  70

 cag ttg gtg gct ctc att ccc tat ggg gac cag agg ctg aag ccc aag      832
 Gln Leu Val Ala Leu Ile Pro Tyr Gly Asp Gln Arg Leu Lys Pro Lys
  75                  80                  85                  90

 cac acg aag ctc ttt gtg ttc ctg gcc gtg ctc atc tgc ctg gtg acc      880
 His Thr Lys Leu Phe Val Phe Leu Ala Val Leu Ile Cys Leu Val Thr
                  95                 100                 105

 tcc tcc ttc atc gtc ttt ttc ctg ttt ccc cgg tcc gtc att gtg cag      928
 Ser Ser Phe Ile Val Phe Phe Leu Phe Pro Arg Ser Val Ile Val Gln
             110                 115                 120

 cct gca ggc ctc aac tcc tcc aca gtg gcc ttt gat gag gct gat atc      976
 Pro Ala Gly Leu Asn Ser Ser Thr Val Ala Phe Asp Glu Ala Asp Ile
         125                 130                 135

 tac ctc aac ata acg aat atc tta aac atc tcc aat ggc aac tac tac     1024
 Tyr Leu Asn Ile Thr Asn Ile Leu Asn Ile Ser Asn Gly Asn Tyr Tyr
     140                 145                 150

 ccc att atg gtg aca cag ctg acc ctc gag gtt ctg cac ctg tcc ctc     1072
 Pro Ile Met Val Thr Gln Leu Thr Leu Glu Val Leu His Leu Ser Leu
 155                 160                 165                 170

 gtg gtg ggg cag gtt tcc aac aac ctt ctc cta cac att ggc cct ttg     1120
 Val Val Gly Gln Val Ser Asn Asn Leu Leu Leu His Ile Gly Pro Leu
                 175                 180                 185

 gcc agt gaa cag atg ttt tac gca gta gct acc aag ata cgg gat gaa     1168
 Ala Ser Glu Gln Met Phe Tyr Ala Val Ala Thr Lys Ile Arg Asp Glu
             190                 195                 200

 aac aca tac aaa atc tgt acc tgg ctg gaa atc aaa gtc cac cat gtg     1216
 Asn Thr Tyr Lys Ile Cys Thr Trp Leu Glu Ile Lys Val His His Val
         205                 210                 215

 ctt ttg cac atc cag ggc acc ctg acc tgt tca tac ctg agc cat tca     1264
 Leu Leu His Ile Gln Gly Thr Leu Thr Cys Ser Tyr Leu Ser His Ser
     220                 225                 230

 gag cag ctg gtc ttt cag agc tat gaa tat gtg gac tgc cga gga aac     1312
 Glu Gln Leu Val Phe Gln Ser Tyr Glu Tyr Val Asp Cys Arg Gly Asn
 235                 240                 245                 250

 gca tct gtg ccc cac cag ctg acc cct cac cca cca tga cctgtctgct      1361
 Ala Ser Val Pro His Gln Leu Thr Pro His Pro Pro 
                 255                 260

 gtccctgtac tccaggcacc tgcaaccctg gtctatatct cccacaactc cctggtgact   1421

 aaggaaggac tacagaggct ttgccaaagg agaagccctg cctcatcaca cccttacctc   1481

 ccaccccctc agcacaggaa gcttgctttg aagttaactt catacacaca cactcatatc   1541

 ctccagtttc ccccagatct ttcaggggct gccatcagat tctgcccttg gttag        1596




      <210> 160
      <211> 1130
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (514)..(942)

      <400> 160
 cctatactaa ttgagatgtt ttcagcagac aaaaataagt cactcttacg catgtaaaaa     60

 tattctttca ctcataataa aagaaatgca acttaaaacc atactgagat cctttttaaa    120

 actgtcagat tggcaaagat caaaaagctt gttaagactc ctagctggca agcatgtggg    180

 aaataggtac tctcataaca gctgacagaa gtacatattg aagaggacaa tatggcaatg    240

 tccttcaaaa ttataaaagc actaactctt tgatccagta gtttccactt ctaggaactt    300

 aaccttcaga tatattttca ccagatataa aatgacatac gtaagaagtt attactgcat    360

 catttgtaat agctaaagat tagaaacaat taattgctat ggaaccctta aaaaaggtgg    420

 ctctaaattc cttaagaaag atatccaaaa caaattaagg ggaaaaggga gggttgcata    480

 acagcatgta acataacact atttgtctaa aga atg ggg aaa gag aag cgg ttg     534
                                      Met Gly Lys Glu Lys Arg Leu
                                        1               5

 tct gtt cac ctc atc ctt gcc act ccg cct tat acc tca cca tcg gag      582
 Ser Val His Leu Ile Leu Ala Thr Pro Pro Tyr Thr Ser Pro Ser Glu
          10                  15                  20

 aac tta cca tcc ccc aaa tat atc ctg ctg gca cta cac ctt cgt aac      630
 Asn Leu Pro Ser Pro Lys Tyr Ile Leu Leu Ala Leu His Leu Arg Asn
      25                  30                  35

 tgc tgt tcc cac tgc ccc cac aac act cca atc tcc acc ttc ctg cca      678
 Cys Cys Ser His Cys Pro His Asn Thr Pro Ile Ser Thr Phe Leu Pro
  40                  45                  50                  55

 acc ttg aga tat tgt atg cat ata tac ata ttt cct ttg ttt aaa ata      726
 Thr Leu Arg Tyr Cys Met His Ile Tyr Ile Phe Pro Leu Phe Lys Ile
                  60                  65                  70

 caa ata gca tac tat gca tgc tgt tct gca ctt tgc ttt ttt ttt ata      774
 Gln Ile Ala Tyr Tyr Ala Cys Cys Ser Ala Leu Cys Phe Phe Phe Ile
              75                  80                  85

 ctt gca att aga gct gcc tca ttt cat ttt aca gct gta tac tat tcc      822
 Leu Ala Ile Arg Ala Ala Ser Phe His Phe Thr Ala Val Tyr Tyr Ser
          90                  95                 100

 att gaa tgg ata aac cat aat tta ttt aat cag tcc ctc act gac aga      870
 Ile Glu Trp Ile Asn His Asn Leu Phe Asn Gln Ser Leu Thr Asp Arg
     105                 110                 115

 cgt ttc cat tgt ttc ctg tct ttt gct ata aat aat gct gta atg aat      918
 Arg Phe His Cys Phe Leu Ser Phe Ala Ile Asn Asn Ala Val Met Asn
 120                 125                 130                 135

 att ctt gtg cat att tca cat taa tttatgggat tacatctgca ggataaattc     972
 Ile Leu Val His Ile Ser His 
                 140

 ttagaaccaa tggtggtttg tggggagggt gacagggtgg ataggtacag gattgggaga   1032

 cttttcactg tatctccttt tgtatttttt tgaattttgt accatatgta tcacctattc   1092

 aaaaaaaata aaatattttt aaatacaaaa aaaaaaaa                           1130




      <210> 161
      <211> 2926
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (75)..(2306)

      <400> 161
 tggaggaggc tgaggaggag aggacagagg tgcctggggc aacctccacc ttgacggttc     60

 cagtgtctgt attt  atg ttg aaa gtc cag gtg aat gac atc atc agt cgt     110
                  Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser Arg
                    1               5                  10

 cag tac ctg agc caa gca gtt gta gaa gtg ttt gta aac tac acg aag      158
 Gln Tyr Leu Ser Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr Lys
          15                  20                  25

 aca aat tcc aca gta act aaa agc aat gga gca gtg ctg ata aaa gta      206
 Thr Asn Ser Thr Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys Val
      30                  35                  40

 ccc tac aaa tta gga ctt agt tta act att att gct tac aaa gat ggc      254
 Pro Tyr Lys Leu Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp Gly
  45                  50                  55                  60

 tac gtg ttg acc cct ctg cct tgg aaa acc aga aga atg cca ata tat      302
 Tyr Val Leu Thr Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile Tyr
                  65                  70                  75

 tca tca gtt aca ctt tca ctg ttc ccg caa agc caa gca aat ata tgg      350
 Ser Ser Val Thr Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile Trp
              80                  85                  90

 cta ttt gaa gac act gtt tta att act gga aaa tta gct gat gcc aag      398
 Leu Phe Glu Asp Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala Lys
          95                 100                 105

 tct caa cca agt gtt cag ttt tca aaa gcc tta att aaa ctt cct gac      446
 Ser Gln Pro Ser Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro Asp
     110                 115                 120

 aac cat cat att agc aac gtt act ggc tat ctt aca gtt cta caa cag      494
 Asn His His Ile Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln Gln
 125                 130                 135                 140

 ttt ttg aaa gtg gac aat ttt ctg cat aca act gga att act ctc aat      542
 Phe Leu Lys Val Asp Asn Phe Leu His Thr Thr Gly Ile Thr Leu Asn
                 145                 150                 155

 aaa cca ggt ttt gaa aac att gaa ttg act cct ctt gct gca ata tgt      590
 Lys Pro Gly Phe Glu Asn Ile Glu Leu Thr Pro Leu Ala Ala Ile Cys
             160                 165                 170

 gtg aaa ata tat tct gga gga aaa gaa cta aag gtc aat ggc tct att      638
 Val Lys Ile Tyr Ser Gly Gly Lys Glu Leu Lys Val Asn Gly Ser Ile
         175                 180                 185

 caa gtt tct ctt cct ctt cta cgt ctg aat gat ata agt gca ggg gat      686
 Gln Val Ser Leu Pro Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly Asp
     190                 195                 200

 cgc ata cct gct tgg aca ttt gat atg aac aca ggt gct tgg gta aat      734
 Arg Ile Pro Ala Trp Thr Phe Asp Met Asn Thr Gly Ala Trp Val Asn
 205                 210                 215                 220

 cat ggt cgg gga atg gtc aag gaa cat aac aat cat tta atc tgg aca      782
 His Gly Arg Gly Met Val Lys Glu His Asn Asn His Leu Ile Trp Thr
                 225                 230                 235

 tat gat gca cca cat ttg ggg tac tgg ata gca gct cca ctt cca gga      830
 Tyr Asp Ala Pro His Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro Gly
             240                 245                 250

 act aga ggt tca ggt ata aat gaa gat tcc aag gac ata act gcc tac      878
 Thr Arg Gly Ser Gly Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala Tyr
         255                 260                 265

 cac aca gtg ttt ctt aca gcc ata tta gga gga aca ata gtc att gtc      926
 His Thr Val Phe Leu Thr Ala Ile Leu Gly Gly Thr Ile Val Ile Val
     270                 275                 280

 att gga ttt ttt gct gta cta ctt tgt tat tgc agg gac aag tgt ggt      974
 Ile Gly Phe Phe Ala Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys Gly
 285                 290                 295                 300

 act cca cag aaa aga gaa aga aat atc act aaa ctt gag gtc ctc aag     1022
 Thr Pro Gln Lys Arg Glu Arg Asn Ile Thr Lys Leu Glu Val Leu Lys
                 305                 310                 315

 aga gac cag aca act tca aca aca cac ata aat cat atc agt aca gtt     1070
 Arg Asp Gln Thr Thr Ser Thr Thr His Ile Asn His Ile Ser Thr Val
             320                 325                 330

 aaa gtt gca tta aaa gct gag gac aag tcg cag tta ttc aat gcc aaa     1118
 Lys Val Ala Leu Lys Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala Lys
         335                 340                 345

 aac tcc tca tat agt cct cag aaa aag gaa cca tca aag gca gaa aca     1166
 Asn Ser Ser Tyr Ser Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu Thr
     350                 355                 360

 gaa gaa aga gtt tcc atg gta aaa act cgg gac gat ttt aaa atc tac     1214
 Glu Glu Arg Val Ser Met Val Lys Thr Arg Asp Asp Phe Lys Ile Tyr
 365                 370                 375                 380

 aat gaa gat gtt tca ttt cta tca gtc aat caa aat aat tac tca aga     1262
 Asn Glu Asp Val Ser Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser Arg
                 385                 390                 395

 aac cca aca cag tct ttg gag ccc aat gta ggg tcc aaa caa cct aaa     1310
 Asn Pro Thr Gln Ser Leu Glu Pro Asn Val Gly Ser Lys Gln Pro Lys
             400                 405                 410

 cat att aac aac aat cta tct tca tct cta ggt gat gct caa gat gaa     1358
 His Ile Asn Asn Asn Leu Ser Ser Ser Leu Gly Asp Ala Gln Asp Glu
         415                 420                 425

 aag agg tat ctc aca ggt aat gag gag gcg tat ggg cgt tcc cat att     1406
 Lys Arg Tyr Leu Thr Gly Asn Glu Glu Ala Tyr Gly Arg Ser His Ile
     430                 435                 440

 cct gaa cag ctt atg cat att tac agc caa ccc att gcc atc ctt caa     1454
 Pro Glu Gln Leu Met His Ile Tyr Ser Gln Pro Ile Ala Ile Leu Gln
 445                 450                 455                 460

 aca tct gac ctt ttc tcc aca ccg gaa caa tta cat act gct aag tca     1502
 Thr Ser Asp Leu Phe Ser Thr Pro Glu Gln Leu His Thr Ala Lys Ser
                 465                 470                 475

 gct act ttg cca aga aag gga cag tta gtc tat ggc caa ttg atg gaa     1550
 Ala Thr Leu Pro Arg Lys Gly Gln Leu Val Tyr Gly Gln Leu Met Glu
             480                 485                 490

 cca gta aat cga gag aac ttt acg cag acc ttg ccc aaa atg cca att     1598
 Pro Val Asn Arg Glu Asn Phe Thr Gln Thr Leu Pro Lys Met Pro Ile
         495                 500                 505

 cat tct cat gca cag ccc cca gat gcc agg gaa gag gat atc ata ctt     1646
 His Ser His Ala Gln Pro Pro Asp Ala Arg Glu Glu Asp Ile Ile Leu
     510                 515                 520

 gaa ggt caa cag agc ctg cca tcc cag gct tca gat tgg agc cga tac     1694
 Glu Gly Gln Gln Ser Leu Pro Ser Gln Ala Ser Asp Trp Ser Arg Tyr
 525                 530                 535                 540

 tca agc agc tta ctg gaa tcc gtc tct gtt cct gga aca cta aat gag     1742
 Ser Ser Ser Leu Leu Glu Ser Val Ser Val Pro Gly Thr Leu Asn Glu
                 545                 550                 555

 gct gtt gta atg act cca ttt tca tcg gaa ctt caa gga att tca gaa     1790
 Ala Val Val Met Thr Pro Phe Ser Ser Glu Leu Gln Gly Ile Ser Glu
             560                 565                 570

 cag acc ctc ctg gag ctg tcc aaa gga aag ccc tcc ccg cat ccc aga     1838
 Gln Thr Leu Leu Glu Leu Ser Lys Gly Lys Pro Ser Pro His Pro Arg
         575                 580                 585

 gcc tgg ttt gtg tct ctt gat gga aag cca gtt gca caa gtg agg cac     1886
 Ala Trp Phe Val Ser Leu Asp Gly Lys Pro Val Ala Gln Val Arg His
     590                 595                 600

 tcc ttt ata gac ctg aaa aag ggc aag aga acc cag agc aat gac acc     1934
 Ser Phe Ile Asp Leu Lys Lys Gly Lys Arg Thr Gln Ser Asn Asp Thr
 605                 610                 615                 620

 agt ctg gac tct ggg gtg gac atg aat gag ctt cac tca agt aga aag     1982
 Ser Leu Asp Ser Gly Val Asp Met Asn Glu Leu His Ser Ser Arg Lys
                 625                 630                 635

 ctc gag agg gag aaa aca ttc atc aaa agc atg cat cag ccc aag atc     2030
 Leu Glu Arg Glu Lys Thr Phe Ile Lys Ser Met His Gln Pro Lys Ile
             640                 645                 650

 ctt tac tta gaa gat tta gac cta agc agc agt gag agt gga acc acc     2078
 Leu Tyr Leu Glu Asp Leu Asp Leu Ser Ser Ser Glu Ser Gly Thr Thr
         655                 660                 665

 gtc tgt tcc cct gag gac cca gct tta agg cac atc cta gat gga ggg     2126
 Val Cys Ser Pro Glu Asp Pro Ala Leu Arg His Ile Leu Asp Gly Gly
     670                 675                 680

 agt gga gtg atc atg gag cac cct gga gaa gag tcg cca gga agg aaa     2174
 Ser Gly Val Ile Met Glu His Pro Gly Glu Glu Ser Pro Gly Arg Lys
 685                 690                 695                 700

 agc act gtt gaa gat ttt gaa gct aat aca tcc ccc act aaa aga agg     2222
 Ser Thr Val Glu Asp Phe Glu Ala Asn Thr Ser Pro Thr Lys Arg Arg
                 705                 710                 715

 ggc aga cca cca cta gcc aaa aga gat agc aag act aac atc tgg aag     2270
 Gly Arg Pro Pro Leu Ala Lys Arg Asp Ser Lys Thr Asn Ile Trp Lys
             720                 725                 730

 aag cga gag gaa cgc cca ctg att ccc ata aat taa ctcc aatggggatt     2320
 Lys Arg Glu Glu Arg Pro Leu Ile Pro Ile Asn 
         735                 740

 gtgtgtctgc tgtctcgtgc tgtttattct tgcttcttgt tgtaaattgc agtacgaact   2380

 taagaaaatg aggctgagca atctcatggt tcttggacat gtctcaagca gagtaaatgg   2440

 taattcagta atcagagaga aagataccaa ggaatgcttt ttctggccta ttcatttatt   2500

 tttgggtgat gaatttacag tatctaagtt ttcaaaatgt aaaatagctt caagatgtta   2560

 gttatctgaa aatgttgctc agccagccag tttggccttg actctcttaa gaataacagt   2620

 gaaatatata ctcctcaagt tgcctccaaa aatgttgcct ctaccatggt gactacccca   2680

 tggaacattt agaaacaaaa ctgacttcag gcatcatatt attttaaatg ttactattac   2740

 gtcttcttct gcctatactt aaaaataact tgataaatga cttggactga tgttactctg   2800

 gagttatcac aaaaaaaatg ttgtttggtc tttaaagagc atgtgtattg tatcatccca   2860

 aacgtaaatc ctacatttat ataagatggg caagaagcta cttggtcatt agagagggag   2920

 acacct                                                              2926




      <210> 162
      <211> 3808
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(2314)

      <400> 162
 gactctgctg tgtcgatcgc ctgagtccgt tttcaccgtt tgcgggatct ggaaccgagt     60

 tacatgc  atg tcc agt ggg ggc agg ttt aat ttt gac gac gga ggg tcc     109
          Met Ser Ser Gly Gly Arg Phe Asn Phe Asp Asp Gly Gly Ser
            1               5                  10

 tac tgt gga ggc tgg gag gac ggc aag gcg cac ggc cat ggc gtc tgc      157
 Tyr Cys Gly Gly Trp Glu Asp Gly Lys Ala His Gly His Gly Val Cys
  15                  20                  25                  30

 acc ggc ccc aag ggc caa ggc gaa tac acc ggc tcg tgg agc cac ggc      205
 Thr Gly Pro Lys Gly Gln Gly Glu Tyr Thr Gly Ser Trp Ser His Gly
                  35                  40                  45

 ttc gag gtg ctg ggc gtc tac acc tgg ccc agc ggc aac acg tac cag      253
 Phe Glu Val Leu Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln
              50                  55                  60

 ggc acc tgg gcg cag ggc aag cgc cac ggc atc ggc ctg gag agc aag      301
 Gly Thr Trp Ala Gln Gly Lys Arg His Gly Ile Gly Leu Glu Ser Lys
          65                  70                  75

 ggg aag tgg gtg tac aag ggc gag tgg acg cac gga ttc aag ggg cgc      349
 Gly Lys Trp Val Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg
      80                  85                  90

 tac ggg gtg cgg gag tgc gcg ggc aac ggg gcc aaa tac gaa ggg acc      397
 Tyr Gly Val Arg Glu Cys Ala Gly Asn Gly Ala Lys Tyr Glu Gly Thr
  95                 100                 105                 110

 tgg agc aac ggg ctg cag gac ggc tac ggg acc gag acc tac tcg gac      445
 Trp Ser Asn Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ser Asp
                 115                 120                 125

 gga ggg acc tac cag ggc cag tgg gtc ggt ggc atg cgc cag ggc tac      493
 Gly Gly Thr Tyr Gln Gly Gln Trp Val Gly Gly Met Arg Gln Gly Tyr
             130                 135                 140

 ggc gtc cgg cag agc gtc ccg tat ggc atg gcc gcg gtc atc cgc tca      541
 Gly Val Arg Gln Ser Val Pro Tyr Gly Met Ala Ala Val Ile Arg Ser
         145                 150                 155

 ccc ctg agg acg tcc atc aac tcc ctg cgc agc gag cac acc aac ggc      589
 Pro Leu Arg Thr Ser Ile Asn Ser Leu Arg Ser Glu His Thr Asn Gly
     160                 165                 170

 acg gcg ctg cat ccc gac gcc tct ccg gcg gtg gcc ggc agc ccg gcc      637
 Thr Ala Leu His Pro Asp Ala Ser Pro Ala Val Ala Gly Ser Pro Ala
 175                 180                 185                 190

 gtg tcc cgc ggg ggc ttc gtg ctc gtg gcc cac agt gac tcc gag atc      685
 Val Ser Arg Gly Gly Phe Val Leu Val Ala His Ser Asp Ser Glu Ile
                 195                 200                 205

 ctc aag agc aag aag aag ggg ctg ttt cgg cgc tcg ctg ctg agt ggg      733
 Leu Lys Ser Lys Lys Lys Gly Leu Phe Arg Arg Ser Leu Leu Ser Gly
             210                 215                 220

 ctg aag ctg cgc aag tcg gag tcc aag agc agc ctg gcc agc caa cgc      781
 Leu Lys Leu Arg Lys Ser Glu Ser Lys Ser Ser Leu Ala Ser Gln Arg
         225                 230                 235

 agc aag cag agc tcc ttt cgc agc gag gcg ggc atg agc acc gtc agc      829
 Ser Lys Gln Ser Ser Phe Arg Ser Glu Ala Gly Met Ser Thr Val Ser
     240                 245                 250

 tcc aca gcc agc gac atc cac tcc acc atc agc ctg ggc gag gct gag      877
 Ser Thr Ala Ser Asp Ile His Ser Thr Ile Ser Leu Gly Glu Ala Glu
 255                 260                 265                 270

 gcc gag ctg gcg gtc atc gag gac gac atc gac gcc acc acc acc gag      925
 Ala Glu Leu Ala Val Ile Glu Asp Asp Ile Asp Ala Thr Thr Thr Glu
                 275                 280                 285

 acc tac gtg ggc gag tgg aag aac gac aaa cgc tcc ggc ttc ggc gtg      973
 Thr Tyr Val Gly Glu Trp Lys Asn Asp Lys Arg Ser Gly Phe Gly Val
             290                 295                 300

 agc cag cgc tcg gac ggg ctc aag tac gag ggc gag tgg gcc agc aac     1021
 Ser Gln Arg Ser Asp Gly Leu Lys Tyr Glu Gly Glu Trp Ala Ser Asn
         305                 310                 315

 cgg cgc cat ggc tac ggc tgc atg acc ttc ccg gac ggc acc aag gag     1069
 Arg Arg His Gly Tyr Gly Cys Met Thr Phe Pro Asp Gly Thr Lys Glu
     320                 325                 330

 gag ggc aag tac aag cag aac atc ctc gtc ggc ggc aag cgc aag aac     1117
 Glu Gly Lys Tyr Lys Gln Asn Ile Leu Val Gly Gly Lys Arg Lys Asn
 335                 340                 345                 350

 ctc atc ccc ctg cgg gcc agc aag atc cgc gag aag gtg gac cgc gcc     1165
 Leu Ile Pro Leu Arg Ala Ser Lys Ile Arg Glu Lys Val Asp Arg Ala
                 355                 360                 365

 gtt gag gcc gct gag cgg gcc gcc acc atc gcc aag cag aag gct gag     1213
 Val Glu Ala Ala Glu Arg Ala Ala Thr Ile Ala Lys Gln Lys Ala Glu
             370                 375                 380

 atc gcg gct tcc agg acc tcc cac tct cgg gca aag gcc gag gca gcc     1261
 Ile Ala Ala Ser Arg Thr Ser His Ser Arg Ala Lys Ala Glu Ala Ala
         385                 390                 395

 ctc aca gca gct cag aaa gcc cag gag gag gcg cgg atc gcc agg atc     1309
 Leu Thr Ala Ala Gln Lys Ala Gln Glu Glu Ala Arg Ile Ala Arg Ile
     400                 405                 410

 act gcc aaa gag ttc tcc cct tcc ttc cag cac cgg gaa aac ggg ctg     1357
 Thr Ala Lys Glu Phe Ser Pro Ser Phe Gln His Arg Glu Asn Gly Leu
 415                 420                 425                 430

 gag tac cag agg ccg aag cgt cag acc tcc tgt gac gac atc gag gtg     1405
 Glu Tyr Gln Arg Pro Lys Arg Gln Thr Ser Cys Asp Asp Ile Glu Val
                 435                 440                 445

 ctg tcc acc ggg aca ccc ctg cag cag gag agc ccc gag ctg tac cgc     1453
 Leu Ser Thr Gly Thr Pro Leu Gln Gln Glu Ser Pro Glu Leu Tyr Arg
             450                 455                 460

 aag ggc acc act ccc tcc gac ctg acc ccc gac gac agc ccc ctg cag     1501
 Lys Gly Thr Thr Pro Ser Asp Leu Thr Pro Asp Asp Ser Pro Leu Gln
         465                 470                 475

 agc ttc ccc acc agc ccc gcg gcc acc ccg ccg ccc gcg ccc gcc gcc     1549
 Ser Phe Pro Thr Ser Pro Ala Ala Thr Pro Pro Pro Ala Pro Ala Ala
     480                 485                 490

 agg aac aag gtc gcc cac ttc tcg agg cag gtg tcg gtg gac gag gag     1597
 Arg Asn Lys Val Ala His Phe Ser Arg Gln Val Ser Val Asp Glu Glu
 495                 500                 505                 510

 cgg ggc ggg gac atc cag atg ctc ctg gag ggc cgg gcc ggg gac tgc     1645
 Arg Gly Gly Asp Ile Gln Met Leu Leu Glu Gly Arg Ala Gly Asp Cys
                 515                 520                 525

 gcc cgc agc agc tgg ggc gag gag cag gcc ggg ggc tcc agg ggt gtc     1693
 Ala Arg Ser Ser Trp Gly Glu Glu Gln Ala Gly Gly Ser Arg Gly Val
             530                 535                 540

 cgc agc ggt gcc ctg cgc ggc ggc ctg ctc gtg gat gac ttc cgc acc     1741
 Arg Ser Gly Ala Leu Arg Gly Gly Leu Leu Val Asp Asp Phe Arg Thr
         545                 550                 555

 cga ggt tcg ggc cgc aag cag ccc ggg aac ccc aag ccg cgg gag cgg     1789
 Arg Gly Ser Gly Arg Lys Gln Pro Gly Asn Pro Lys Pro Arg Glu Arg
     560                 565                 570

 cgg acg gag tca ccc ccc gtg ttc acg tgg act tcc cac cac cgg gcc     1837
 Arg Thr Glu Ser Pro Pro Val Phe Thr Trp Thr Ser His His Arg Ala
 575                 580                 585                 590

 agc aac cac agc ccc gga ggc tcc agg ctg ctg gag ctg cag gag gag     1885
 Ser Asn His Ser Pro Gly Gly Ser Arg Leu Leu Glu Leu Gln Glu Glu
                 595                 600                 605

 aag ctg agc aac tac cgg atg gag atg aaa ccc ttg ctg agg atg gag     1933
 Lys Leu Ser Asn Tyr Arg Met Glu Met Lys Pro Leu Leu Arg Met Glu
             610                 615                 620

 acg cac ccc cag aaa aga cgc tac agc aag ggc ggc gcc tgc cgg ggc     1981
 Thr His Pro Gln Lys Arg Arg Tyr Ser Lys Gly Gly Ala Cys Arg Gly
         625                 630                 635

 ttg ggg gac gac cac cgc ccc gag gac cgg ggc ttc ggg gtg cag aga     2029
 Leu Gly Asp Asp His Arg Pro Glu Asp Arg Gly Phe Gly Val Gln Arg
     640                 645                 650

 ctg cgg tcc aag gcc cag aac aag gag aac ttc agg ccg gcc tcc tcc     2077
 Leu Arg Ser Lys Ala Gln Asn Lys Glu Asn Phe Arg Pro Ala Ser Ser
 655                 660                 665                 670

 gcg gag ccc gcc gtg cag aaa ctg gcg agc ctg cgg ctg ggc ggg gcc     2125
 Ala Glu Pro Ala Val Gln Lys Leu Ala Ser Leu Arg Leu Gly Gly Ala
                 675                 680                 685

 gag ccc cgg ttg ctg cgt tgg gac ttg acc ttc tcc ccg ccc cag aaa     2173
 Glu Pro Arg Leu Leu Arg Trp Asp Leu Thr Phe Ser Pro Pro Gln Lys
             690                 695                 700

 tcc ttg cct gtc gct cta gag tcc gac gag gag aat ggg gat gag ctc     2221
 Ser Leu Pro Val Ala Leu Glu Ser Asp Glu Glu Asn Gly Asp Glu Leu
         705                 710                 715

 aag tcc agt acg ggc tca gcg cct atc ctg gtg gtc atg gtg atc ttg     2269
 Lys Ser Ser Thr Gly Ser Ala Pro Ile Leu Val Val Met Val Ile Leu
     720                 725                 730

 ctc aac atc gga gtc gcc att ctg ttt att aac ttt ttc atc tga tga     2317
 Leu Asn Ile Gly Val Ala Ile Leu Phe Ile Asn Phe Phe Ile 
 735                 740                 745

 gatgtcgcgg tagcaaaaat agagaaaggg tagaaaaaag ggacattaaa attaaaagca   2377

 aaaccacaag aagggaaaga ccgcaactcg gacagcccag cgacttccaa gtcctctcac   2437

 agaagaacca cacgattggg tatcactcac agtttgcctt tttttctggg taatgttttt   2497

 tggattttag ccaaaattct ttgcttgtat aacactctgc tgtgtggcat ggcagaagga   2557

 ggccagcacg cagcccctcc agctccacgt ggagacagaa gggatcccgg cacatcagtg   2617

 gtaacagcgg acgttgtcct cgtggtcaca cgtcccgtct tgggtgtgga tggagggcag   2677

 cccggggcag agcctcagcc ccgcggcccc tgagtggcag ggctgactcc cgtcgacacg   2737

 agcttagaaa gtggattcac tgctttctct gtctagaaca gacgggtgac aagtatgggc   2797

 aggaggcatg gggcagggtg gcccacccca gtgggcagta gcctggcctt tttctgtgtg   2857

 agatctgtgc tgcacacctg agggaggggg agggatcggc cacctcctcc ctgtgagacg   2917

 gatgcaggtc cttccctctt ctcggcactg cccccggcct tccatgagaa gccgactccc   2977

 cacaccgagt tttaaagcaa agcccttttc ttctgctgcc cactcactgt gggtcccatt   3037

 cggctgtttc ccccaccaga ccccagggaa gccggggccc actccgatcc gcctgggctc   3097

 agctaagcac ggaagccaag ggggctgtgc cgtggagctg ggctcgcgcc ggggctctgg   3157

 gtgtgtgcgc ttggcgtgca gggtggacgc gtggggttcc gtgtccccag cagtgagggc   3217

 cctagaggac gccttctccc atggttactg atctccacgg gttttcacat ctctgtactg   3277

 tgcctgcctc aacttcccct aacagatatg catattcctt ccagatgcct cagtgctaca   3337

 ccacagtggg cctggtccca ggacaggaat gcggttcaaa cccagtggct tgaaacttcc   3397

 tgagaaactg tagcatatcc agccccctaa aatgtacaat gtaacttgtt cagtccaaca   3457

 aaaacaggtt ccttatgttt ctgccttctc caccagggtc gctccatcac ccaaacaaaa   3517

 gaacaaggtt tgccaggatg tccgagtgcc ccctggccct ggctctcgtg tgcatggacg   3577

 tgcctgaggg gtccgggcac ggccatacgc aggacccctg tgcccgggga ggcgctgcag   3637

 ggattcccca tccggtcgtc ttggggccag cccgtcttat ggactctgcc ttgctttgct   3697

 tatgtttagc tgtttctctg ctacctttcg agcagacttc tttactacac tgcactggat   3757

 tgctatattt ttaaccagaa ataaactaaa gattagagca aaaaaaaaaa a            3808




      <210> 163
      <211> 1111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (374)..(841)

      <400> 163
 tggaccctta ctggacactc tgccaagtaa ctggagtggt acttgcactc ttgtccaatt     60

 cgctatccct tttgcccttg catttcttca accagaaaaa gaaaagccac aacaccgtaa    120

 aataagagaa gccccttatg ggtcttttga ctctcaagtt tatttagacg caactggagt    180

 cccacaggga gtaccacaca aattcaaagc tcaagaccag atagctgcag gatttgaatc    240

 aatattttgg tgggtaacta tcagtaaaaa catagattgg ataaattaca tctattataa    300

 ccagcagcgg tttattaact acactagaga tgctgtcaaa ggaatagctg aacagttagg    360

 gcctactagc cag   atg gct tgg gaa aac aga atg gcc cta gac atg ata     409
                  Met Ala Trp Glu Asn Arg Met Ala Leu Asp Met Ile
                    1               5                  10

 tta gcc aaa aaa ggt gga gtt tgt gtt atg atc aaa act caa tgt tgt      457
 Leu Ala Lys Lys Gly Gly Val Cys Val Met Ile Lys Thr Gln Cys Cys
          15                  20                  25

 acc ttc atc cca aac aat act gcc cct agt ggg agc ata aca agg gcc      505
 Thr Phe Ile Pro Asn Asn Thr Ala Pro Ser Gly Ser Ile Thr Arg Ala
      30                  35                  40

 tta caa ggc ctt act gct tta tcc aat gaa tta gct aaa aat tct gga      553
 Leu Gln Gly Leu Thr Ala Leu Ser Asn Glu Leu Ala Lys Asn Ser Gly
  45                  50                  55                  60

 gtc aat gac cct ttt tca gga tgg cta gaa agg tgg ttt ggt aaa tgg      601
 Val Asn Asp Pro Phe Ser Gly Trp Leu Glu Arg Trp Phe Gly Lys Trp
                  65                  70                  75

 aaa gga atc ata gcc tca att ctt act tct ctt gca gcc gta ata ggt      649
 Lys Gly Ile Ile Ala Ser Ile Leu Thr Ser Leu Ala Ala Val Ile Gly
              80                  85                  90

 gta gtc att ctt ttt ggg tgt tgt gtc aca cca tgt atc cgt ggg cta      697
 Val Val Ile Leu Phe Gly Cys Cys Val Thr Pro Cys Ile Arg Gly Leu
          95                 100                 105

 gta cag agg ctt ata gaa aca gta ctt act aaa acc tcc ctt agc tct      745
 Val Gln Arg Leu Ile Glu Thr Val Leu Thr Lys Thr Ser Leu Ser Ser
     110                 115                 120

 cct cca cct tat tca gat aag ctt ttc ctt tta aag gat caa gtc gaa      793
 Pro Pro Pro Tyr Ser Asp Lys Leu Phe Leu Leu Lys Asp Gln Val Glu
 125                 130                 135                 140

 cag caa agc cca gac atg tta aaa agg ttt aaa gag aaa aga tta taa      841
 Gln Gln Ser Pro Asp Met Leu Lys Arg Phe Lys Glu Lys Arg Leu 
                 145                 150                 155

 aaattaaaag cagggaactg taagatataa tgaatttctc ttcaaaggtt cagcctgtta    901

 acttccttgt tctttgttct caaactcaac tttcttgtcc tccatgcctc cttgcctcta    961

 gttactgtaa acaaccttcc catcagcttt aatcaataac tcacatctgt tcccttggtt   1021

 acccactctg cacccattcc acctttttga aaccacacgt ccaaccttcg aaaccacaca   1081

 tcccaccact gtaactcacc ttccccttcc                                    1111




      <210> 164
      <211> 1633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1571)

      <400> 164
 tgctcactga cctctaccag gccacc atg gcg ttg ggc tat tgg cgc gcg ggc      53
                              Met Ala Leu Gly Tyr Trp Arg Ala Gly
                                1               5

 cgg gcg cgg gac gcc gcc gag ttc gag ctc ttc ttc cgc cgc tgc ccg      101
 Arg Ala Arg Asp Ala Ala Glu Phe Glu Leu Phe Phe Arg Arg Cys Pro
  10                  15                  20                  25

 ttc ggc ggc gcc ttc gcc ttg gcc gcc ggc ttg cgc gac tgt gtg cgc      149
 Phe Gly Gly Ala Phe Ala Leu Ala Ala Gly Leu Arg Asp Cys Val Arg
                  30                  35                  40

 ttc ctg cgc gcc ttc cgc ctg cgg gac gcc gac gtg cag ttc ctg gcc      197
 Phe Leu Arg Ala Phe Arg Leu Arg Asp Ala Asp Val Gln Phe Leu Ala
              45                  50                  55

 tcg gtg ctg ccc cca gac acg gat cct gcg ttc ttc gag cac ctt cgg      245
 Ser Val Leu Pro Pro Asp Thr Asp Pro Ala Phe Phe Glu His Leu Arg
          60                  65                  70

 gcc ctc gac tgc tcc gag gtg acg gtg cga gcc ctg ccc gag ggc tcc      293
 Ala Leu Asp Cys Ser Glu Val Thr Val Arg Ala Leu Pro Glu Gly Ser
      75                  80                  85

 ctc gcc ttc ccc gga gtg ccg ctc ctg cag gtg tcc ggg ccg ctc ctg      341
 Leu Ala Phe Pro Gly Val Pro Leu Leu Gln Val Ser Gly Pro Leu Leu
  90                  95                 100                 105

 gtg gtg cag ctg ctg gag aca ccg ctg ctc tgc ctg gtc agc tac gcc      389
 Val Val Gln Leu Leu Glu Thr Pro Leu Leu Cys Leu Val Ser Tyr Ala
                 110                 115                 120

 agc ctg gtg gcc acc aac gca gcg cgg ctt cgc ttg atc gca ggg cca      437
 Ser Leu Val Ala Thr Asn Ala Ala Arg Leu Arg Leu Ile Ala Gly Pro
             125                 130                 135

 gag aag cgg ctg cta gag atg ggc ctg agg cgg gct cag ggc ccc gat      485
 Glu Lys Arg Leu Leu Glu Met Gly Leu Arg Arg Ala Gln Gly Pro Asp
         140                 145                 150

 ggg ggc ctg aca gcc tcc acc tac agc tac ctg ggc ggc ttc gac agc      533
 Gly Gly Leu Thr Ala Ser Thr Tyr Ser Tyr Leu Gly Gly Phe Asp Ser
     155                 160                 165

 agc agc aac gtg cta gcg ggc cag ctg cga ggt gtg ccg gtg gcc ggg      581
 Ser Ser Asn Val Leu Ala Gly Gln Leu Arg Gly Val Pro Val Ala Gly
 170                 175                 180                 185

 acc ctg gcc cac tcc ttc gtc act tcc ttt tca ggc agc gag gtg ccc      629
 Thr Leu Ala His Ser Phe Val Thr Ser Phe Ser Gly Ser Glu Val Pro
                 190                 195                 200

 cct gac ccg atg ttg gcg cca gca gct ggt gag ggc cct ggg gtg gac      677
 Pro Asp Pro Met Leu Ala Pro Ala Ala Gly Glu Gly Pro Gly Val Asp
             205                 210                 215

 ctg gcg gcc aaa gcc cag gtg tgg ctg gag cag gtg tgt gcc cac ctg      725
 Leu Ala Ala Lys Ala Gln Val Trp Leu Glu Gln Val Cys Ala His Leu
         220                 225                 230

 ggg ctg ggg gtg cag gag ccg cat cca ggc gag cgg gca gcc ttt gtg      773
 Gly Leu Gly Val Gln Glu Pro His Pro Gly Glu Arg Ala Ala Phe Val
     235                 240                 245

 gcc tat gcc ttg gct ttt ccc cgg gcc ttc cag ggc ctc ctg gac acc      821
 Ala Tyr Ala Leu Ala Phe Pro Arg Ala Phe Gln Gly Leu Leu Asp Thr
 250                 255                 260                 265

 tac agc gtg tgg agg agt ggt ctc ccc aac ttc cta gca gtc gcc ctg      869
 Tyr Ser Val Trp Arg Ser Gly Leu Pro Asn Phe Leu Ala Val Ala Leu
                 270                 275                 280

 gcc ctg gga gag ctg ggc tac cgg gca gtg ggc gtg agg ctg gac agt      917
 Ala Leu Gly Glu Leu Gly Tyr Arg Ala Val Gly Val Arg Leu Asp Ser
             285                 290                 295

 ggt gac ctg cta cag cag gct cag gag atc cgc aag gtc ttc cga gct      965
 Gly Asp Leu Leu Gln Gln Ala Gln Glu Ile Arg Lys Val Phe Arg Ala
         300                 305                 310

 gct gca gcc cag ttc cag gtg ccc tgg ctg gag tca gtc ctc atc gta     1013
 Ala Ala Ala Gln Phe Gln Val Pro Trp Leu Glu Ser Val Leu Ile Val
     315                 320                 325

 gtc agc aac aac att gac gag gag gcg ctg gcc cga ctg gcc cag gag     1061
 Val Ser Asn Asn Ile Asp Glu Glu Ala Leu Ala Arg Leu Ala Gln Glu
 330                 335                 340                 345

 ggc agt gag gtg aat gtc att ggc att ggc acc agt gtg gtc acc tgc     1109
 Gly Ser Glu Val Asn Val Ile Gly Ile Gly Thr Ser Val Val Thr Cys
                 350                 355                 360

 ccc caa cag cct tcc ctg ggt ggc gtc tat aag ctg gtg gcc gtg ggg     1157
 Pro Gln Gln Pro Ser Leu Gly Gly Val Tyr Lys Leu Val Ala Val Gly
             365                 370                 375

 ggc cag cca cga atg aag ctg acc gag gac ccc gag aag cag acg ttg     1205
 Gly Gln Pro Arg Met Lys Leu Thr Glu Asp Pro Glu Lys Gln Thr Leu
         380                 385                 390

 cct ggg agc aag gct gct ttc cgg ctc ctg ggc tct gac ggg tct cca     1253
 Pro Gly Ser Lys Ala Ala Phe Arg Leu Leu Gly Ser Asp Gly Ser Pro
     395                 400                 405

 ctc atg gac atg ctg cag tta gca gaa gag cca gtg cca cag gct ggg     1301
 Leu Met Asp Met Leu Gln Leu Ala Glu Glu Pro Val Pro Gln Ala Gly
 410                 415                 420                 425

 cag gag ctg agg gtg tgg cct cca ggg gcc cag gag ccc tgc acc gtg     1349
 Gln Glu Leu Arg Val Trp Pro Pro Gly Ala Gln Glu Pro Cys Thr Val
                 430                 435                 440

 agg cca gcc cag gtg gag cca cta ctg cgg ctc tgc ctc cag cag gga     1397
 Arg Pro Ala Gln Val Glu Pro Leu Leu Arg Leu Cys Leu Gln Gln Gly
             445                 450                 455

 cag ctg tgt gag ccg ctc cca tcc ctg gca gag tct aga gcc ttg gcc     1445
 Gln Leu Cys Glu Pro Leu Pro Ser Leu Ala Glu Ser Arg Ala Leu Ala
         460                 465                 470

 cag ctg tcc ctg agc cga ctc agc cct gag cac agg cgg ctg cgg agc     1493
 Gln Leu Ser Leu Ser Arg Leu Ser Pro Glu His Arg Arg Leu Arg Ser
     475                 480                 485

 cct gca cag tac cag gtg gtg ctg tcc gag agg ctg cag gcc ctg gtg     1541
 Pro Ala Gln Tyr Gln Val Val Leu Ser Glu Arg Leu Gln Ala Leu Val
 490                 495                 500                 505

 aac agt ctg tgt gcg ggg cag tcc ccc tga g actcggagcg gggctgactg     1592
 Asn Ser Leu Cys Ala Gly Gln Ser Pro 
                 510

 gaaacaacac gaatcactca cttttcccca caaaaaaaaa a                       1633




      <210> 165
      <211> 1406
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1352)

      <400> 165
 tgctcactga cctctaccag gccacc atg gcg ttg ggc tat tgg cgc gcg ggc      53
                              Met Ala Leu Gly Tyr Trp Arg Ala Gly
                                1               5

 cgg gcg cgg gac gcc gcc gag ttc gag ctc ttc ttc cgc cgc tgc ccg      101
 Arg Ala Arg Asp Ala Ala Glu Phe Glu Leu Phe Phe Arg Arg Cys Pro
  10                  15                  20                  25

 ttc ggc ggc gcc ttc gcc ttg gcc gcc ggc ttg cgc gac tgt gtg cgc      149
 Phe Gly Gly Ala Phe Ala Leu Ala Ala Gly Leu Arg Asp Cys Val Arg
                  30                  35                  40

 ttc ctg cgc gcc ttc cgc ctg cgg gac gcc gac gtg cag ttc ctg gcc      197
 Phe Leu Arg Ala Phe Arg Leu Arg Asp Ala Asp Val Gln Phe Leu Ala
              45                  50                  55

 tcg gtg ctg ccc cca gac acg gat cct gcg ttc ttc gag cac ctt cgg      245
 Ser Val Leu Pro Pro Asp Thr Asp Pro Ala Phe Phe Glu His Leu Arg
          60                  65                  70

 gcc ctc gac tgc tcc gag gtg acg gtg cga gcc ctg ccc gag ggc tcc      293
 Ala Leu Asp Cys Ser Glu Val Thr Val Arg Ala Leu Pro Glu Gly Ser
      75                  80                  85

 ctc gcc ttc ccc gga gtg ccg ctc ctg cag gtg tcc ggg ccg ctc ctg      341
 Leu Ala Phe Pro Gly Val Pro Leu Leu Gln Val Ser Gly Pro Leu Leu
  90                  95                 100                 105

 gtg gtg cag ctg ctg gag aca ccg ctg ctc tgc ctg gtc agc tac gcc      389
 Val Val Gln Leu Leu Glu Thr Pro Leu Leu Cys Leu Val Ser Tyr Ala
                 110                 115                 120

 agc ctg gtg gcc acc aac gca gcg cgg ctt cgc ttg atc gca ggg cca      437
 Ser Leu Val Ala Thr Asn Ala Ala Arg Leu Arg Leu Ile Ala Gly Pro
             125                 130                 135

 gag aag cgg ctg cta gag atg ggc ctg agg cgg gct cag ggc ccc gat      485
 Glu Lys Arg Leu Leu Glu Met Gly Leu Arg Arg Ala Gln Gly Pro Asp
         140                 145                 150

 ggg ggc ctg aca gcc tcc acc tac agc tac ctg ggc ggc ttc gac agc      533
 Gly Gly Leu Thr Ala Ser Thr Tyr Ser Tyr Leu Gly Gly Phe Asp Ser
     155                 160                 165

 agc agc aac gtg cta gcg ggc cag ctg cga ggt gtg ccg gtg gcc ggg      581
 Ser Ser Asn Val Leu Ala Gly Gln Leu Arg Gly Val Pro Val Ala Gly
 170                 175                 180                 185

 acc ctg gcc cac tcc ttc gtc act tcc ttt tca ggc agc gag gtg ccc      629
 Thr Leu Ala His Ser Phe Val Thr Ser Phe Ser Gly Ser Glu Val Pro
                 190                 195                 200

 cct gac ccg atg ttg gcg cca gca gct ggt gag ggc cct ggg gtg gac      677
 Pro Asp Pro Met Leu Ala Pro Ala Ala Gly Glu Gly Pro Gly Val Asp
             205                 210                 215

 ctg gcg gcc aaa gcc cag gtg tgg ctg gag cag gtg tgt gcc cac ctg      725
 Leu Ala Ala Lys Ala Gln Val Trp Leu Glu Gln Val Cys Ala His Leu
         220                 225                 230

 ggg ctg ggg gtg cag gag ccg cat cca ggc gag cgg gca gcc ttt gtg      773
 Gly Leu Gly Val Gln Glu Pro His Pro Gly Glu Arg Ala Ala Phe Val
     235                 240                 245

 gcc tat gcc ttg gct ttt ccc cgg gcc ttc cag ggc ctc ctg gac acc      821
 Ala Tyr Ala Leu Ala Phe Pro Arg Ala Phe Gln Gly Leu Leu Asp Thr
 250                 255                 260                 265

 tac agc gtg tgg agg agt ggt ctc ccc aac ttc cta gca gtc gcc ctg      869
 Tyr Ser Val Trp Arg Ser Gly Leu Pro Asn Phe Leu Ala Val Ala Leu
                 270                 275                 280

 gcc ctg gga gag ctg ggc tac cgg gca gtg ggc gtg agg ctg gac agt      917
 Ala Leu Gly Glu Leu Gly Tyr Arg Ala Val Gly Val Arg Leu Asp Ser
             285                 290                 295

 ggt gac ctg cta cag cag gct cag gag atc cgc aag gtc ttc cga gct      965
 Gly Asp Leu Leu Gln Gln Ala Gln Glu Ile Arg Lys Val Phe Arg Ala
         300                 305                 310

 gct gca gcc cag ttc cag gtg ccc tgg ctg gag tca gtc ctc atc gta     1013
 Ala Ala Ala Gln Phe Gln Val Pro Trp Leu Glu Ser Val Leu Ile Val
     315                 320                 325

 gtc agc aac aac att gac gag gag gcg ctg gcc cga ctg gcc cag gag     1061
 Val Ser Asn Asn Ile Asp Glu Glu Ala Leu Ala Arg Leu Ala Gln Glu
 330                 335                 340                 345

 ggc agt gag gtg aat gtc att ggc att ggc acc agt gtg gtc acc tgc     1109
 Gly Ser Glu Val Asn Val Ile Gly Ile Gly Thr Ser Val Val Thr Cys
                 350                 355                 360

 ccc caa cag cct tcc ctg ggt ggc gtc tat aag ctg gtg gcc gtg ggg     1157
 Pro Gln Gln Pro Ser Leu Gly Gly Val Tyr Lys Leu Val Ala Val Gly
             365                 370                 375

 ggc cag cca cga atg aag ctg acc gag gac ccc gag aag cag acg ttg     1205
 Gly Gln Pro Arg Met Lys Leu Thr Glu Asp Pro Glu Lys Gln Thr Leu
         380                 385                 390

 cct ggg agc aag gct gct ttc cgg ctc ctg ggc tct gac ggt gag gcc     1253
 Pro Gly Ser Lys Ala Ala Phe Arg Leu Leu Gly Ser Asp Gly Glu Ala
     395                 400                 405

 ctc cca tcc ccc ctg ctg tcc acc ttc aaa gca cca ggg ccc ccg ctt     1301
 Leu Pro Ser Pro Leu Leu Ser Thr Phe Lys Ala Pro Gly Pro Pro Leu
 410                 415                 420                 425

 att ctt gcc ccg tcc aca cag ggt ctc cac tca tgg aca tgc tgc agt     1349
 Ile Leu Ala Pro Ser Thr Gln Gly Leu His Ser Trp Thr Cys Cys Ser
                 430                 435                 440

 tag caga agagccagtg ccacaggctg ggcaggagct gagggtgtgg cctccagggg     1406
 






      <210> 166
      <211> 1594
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (27)..(1532)

      <400> 166
 tgctcactga cctctaccag gccacc atg gcg ttg ggc tat tgg cgc gcg ggc      53
                              Met Ala Leu Gly Tyr Trp Arg Ala Gly
                                1               5

 cgg gcg cgg gac gcc gcc gag ttc gag ctc ttc ttc cgc cgc tgc ccg      101
 Arg Ala Arg Asp Ala Ala Glu Phe Glu Leu Phe Phe Arg Arg Cys Pro
  10                  15                  20                  25

 ttc ggc ggc gcc ttc gcc ttg gcc gcc ggc ttg cgc gac tgt gtg cgc      149
 Phe Gly Gly Ala Phe Ala Leu Ala Ala Gly Leu Arg Asp Cys Val Arg
                  30                  35                  40

 ttc ctg cgc gcc ttc cgc ctg cgg gac gcc gac gtg cag ttc ctg gcc      197
 Phe Leu Arg Ala Phe Arg Leu Arg Asp Ala Asp Val Gln Phe Leu Ala
              45                  50                  55

 tcg gtg ctg ccc cca gac acg gat cct gcg ttc ttc gag cac ctt cgg      245
 Ser Val Leu Pro Pro Asp Thr Asp Pro Ala Phe Phe Glu His Leu Arg
          60                  65                  70

 gcc ctc gac tgc tcc gag gtg acg gtg cga gcc ctg ccc gag ggc tcc      293
 Ala Leu Asp Cys Ser Glu Val Thr Val Arg Ala Leu Pro Glu Gly Ser
      75                  80                  85

 ctc gcc ttc ccc gga gtg ccg ctc ctg cag gtg tcc ggg ccg ctc ctg      341
 Leu Ala Phe Pro Gly Val Pro Leu Leu Gln Val Ser Gly Pro Leu Leu
  90                  95                 100                 105

 gtg gtg cag ctg ctg gag aca ccg ctg ctc tgc ctg gtc agc tac gcc      389
 Val Val Gln Leu Leu Glu Thr Pro Leu Leu Cys Leu Val Ser Tyr Ala
                 110                 115                 120

 agc ctg gtg gcc acc aac gca gcg cgg ctt cgc ttg atc gca ggg cca      437
 Ser Leu Val Ala Thr Asn Ala Ala Arg Leu Arg Leu Ile Ala Gly Pro
             125                 130                 135

 gag aag cgg ctg cta gag atg ggc ctg agg cgg gct cag ggc ccc gat      485
 Glu Lys Arg Leu Leu Glu Met Gly Leu Arg Arg Ala Gln Gly Pro Asp
         140                 145                 150

 ggg ggc ctg aca gcc tcc acc tac agc tac ctg ggc ggc ttc gac agc      533
 Gly Gly Leu Thr Ala Ser Thr Tyr Ser Tyr Leu Gly Gly Phe Asp Ser
     155                 160                 165

 agc agc aac gtg cta gcg ggc cag ctg cga ggt gtg ccg gtg gcc ggg      581
 Ser Ser Asn Val Leu Ala Gly Gln Leu Arg Gly Val Pro Val Ala Gly
 170                 175                 180                 185

 acc ctg gcc cac tcc ttc gtc act tcc ttt tca ggc agc gag gtg ccc      629
 Thr Leu Ala His Ser Phe Val Thr Ser Phe Ser Gly Ser Glu Val Pro
                 190                 195                 200

 cct gac ccg atg ttg gcg cca gca gct ggt gag ggc cct ggg gtg gac      677
 Pro Asp Pro Met Leu Ala Pro Ala Ala Gly Glu Gly Pro Gly Val Asp
             205                 210                 215

 ctg gcg gcc aaa gcc cag gtg tgg ctg gag cag gtg tgt gcc cac ctg      725
 Leu Ala Ala Lys Ala Gln Val Trp Leu Glu Gln Val Cys Ala His Leu
         220                 225                 230

 ggg ctg ggg gtg cag gag ccg cat cca ggc gag cgg gca gcc ttt gtg      773
 Gly Leu Gly Val Gln Glu Pro His Pro Gly Glu Arg Ala Ala Phe Val
     235                 240                 245

 gcc tat gcc ttg gct ttt ccc cgg gcc ttc cag ggc ctc ctg gac acc      821
 Ala Tyr Ala Leu Ala Phe Pro Arg Ala Phe Gln Gly Leu Leu Asp Thr
 250                 255                 260                 265

 tac agc gtg tgg agg agt ggt ctc ccc aac ttc cta gca gtc gcc ctg      869
 Tyr Ser Val Trp Arg Ser Gly Leu Pro Asn Phe Leu Ala Val Ala Leu
                 270                 275                 280

 gcc ctg gga gag ctg ggc tac cgg gca gtg ggc gtg agg ctg gac agt      917
 Ala Leu Gly Glu Leu Gly Tyr Arg Ala Val Gly Val Arg Leu Asp Ser
             285                 290                 295

 ggt gac ctg cta cag cag gct cag gag atc cgc aag gtc ttc cga gct      965
 Gly Asp Leu Leu Gln Gln Ala Gln Glu Ile Arg Lys Val Phe Arg Ala
         300                 305                 310

 gct gca gcc cag ttc cag gtg ccc tgg ctg gag tca gtc ctc atc gta     1013
 Ala Ala Ala Gln Phe Gln Val Pro Trp Leu Glu Ser Val Leu Ile Val
     315                 320                 325

 gtc agc aac aac att gac gag gag gcg ctg gcc cga ctg gcc cag gag     1061
 Val Ser Asn Asn Ile Asp Glu Glu Ala Leu Ala Arg Leu Ala Gln Glu
 330                 335                 340                 345

 ggc agt gag gtg aat gtc att ggc att ggc acc agt gtg gtc acc tgc     1109
 Gly Ser Glu Val Asn Val Ile Gly Ile Gly Thr Ser Val Val Thr Cys
                 350                 355                 360

 ccc caa cag cct tcc ctg ggt ggc gtc tat aag ctg gtg gcc gtg ggg     1157
 Pro Gln Gln Pro Ser Leu Gly Gly Val Tyr Lys Leu Val Ala Val Gly
             365                 370                 375

 ggc cag cca cga atg aag ctg acc gag gac ccc gag aag cag acg ttg     1205
 Gly Gln Pro Arg Met Lys Leu Thr Glu Asp Pro Glu Lys Gln Thr Leu
         380                 385                 390

 cct ggg agc aag gct gct ttc cgg ctc ctg ggc tct gac ggg tct cca     1253
 Pro Gly Ser Lys Ala Ala Phe Arg Leu Leu Gly Ser Asp Gly Ser Pro
     395                 400                 405

 ctc atg gac atg ctg cag tta gca gaa gag cca gtg cca cag gct ggg     1301
 Leu Met Asp Met Leu Gln Leu Ala Glu Glu Pro Val Pro Gln Ala Gly
 410                 415                 420                 425

 cag gag ctg agg gtg tgg cct cca ggg gcc cag gag ccc tgc acc gtg     1349
 Gln Glu Leu Arg Val Trp Pro Pro Gly Ala Gln Glu Pro Cys Thr Val
                 430                 435                 440

 agg cca gcc cag ctg tgt gag ccg ctc cca tcc ctg gca gag tct aga     1397
 Arg Pro Ala Gln Leu Cys Glu Pro Leu Pro Ser Leu Ala Glu Ser Arg
             445                 450                 455

 gcc ttg gcc cag ctg tcc ctg agc cga ctc agc cct gag cac agg cgg     1445
 Ala Leu Ala Gln Leu Ser Leu Ser Arg Leu Ser Pro Glu His Arg Arg
         460                 465                 470

 ctg cgg agc cct gca cag tac cag gtg gtg ctg tcc gag agg ctg cag     1493
 Leu Arg Ser Pro Ala Gln Tyr Gln Val Val Leu Ser Glu Arg Leu Gln
     475                 480                 485

 gcc ctg gtg aac agt ctg tgt gcg ggg cag tcc ccc tga gactcggagc      1542
 Ala Leu Val Asn Ser Leu Cys Ala Gly Gln Ser Pro 
 490                 495                 500

 ggggctgact ggaaacaaca cgaatcactc acttttcccc acaaaaaaaa aa           1594




      <210> 167
      <211> 1733
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (406)..(1221)

      <220>
      <221> misc_feature
      <222> (1)...(1733)
      <223> n = a,t,c or g

      <400> 167
 gcagctacag aggaaagttt ggatatgtgc atctttgtgg ataagggtcg ctgtgctggc     60

 tgcctgttac caggacagct cttagtgcaa ctgggctttg gtaaatggaa aaagggatca    120

 ttagaggaga tgacagggtt gccaaaggga ctggagaaag aagagactgg gcagctgaag    180

 acaagcatca aggatgacat catagctttg tttaaagcca ccttcagaga acacaaactt    240

 acaacaaatt gcaaatctgt attgacagtt gtagaaattg ggcagcctta tcatggagca    300

 cccagaataa ctccctttta ctgggtctgg cgagccggcg ccggccgagc tgcgggagcc    360

 gcggagagca ccagctgtcg ccgcgggagc tgctccggcc gcacc    atg cgg gag     414
                                                      Met Arg Glu
                                                        1

 ctg gcc att gag atc ggg gtg cga gcc ctg ctc ttc gga gtc ttc gtt      462
 Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly Val Phe Val
       5                  10                  15

 ttt aca gag ttt ttg gat ccg ttc cag aga gtc atc cag cca gaa gag      510
 Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln Pro Glu Glu
  20                  25                  30                  35

 atc tgg ctc tat aaa aat cct ttg gtg caa tca gat aac ata cct acc      558
 Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn Ile Pro Thr
                  40                  45                  50

 cgc ctc atg ttt gca att tct ttc ctc aca ccc ctg gct gtt att tgt      606
 Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala Val Ile Cys
              55                  60                  65

 gtg gtg aaa att atc cgg cga aca gac aag act gaa att aag gaa gcc      654
 Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile Lys Glu Ala
          70                  75                  80

 ttc tta gcg gtg tcc ttg gct ctt gct ttg aat gga gtc tgc aca aac      702
 Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val Cys Thr Asn
      85                  90                  95

 act att aaa tta ata gtg gga aga cct cgc ccc gat ttc ttt tac cgc      750
 Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr Arg
 100                 105                 110                 115

 tgc ttt cca gat gga gtg atg aac tcg gaa atg cat tgc aca ggt gac      798
 Cys Phe Pro Asp Gly Val Met Asn Ser Glu Met His Cys Thr Gly Asp
                 120                 125                 130

 ccc gat ctg gtg tcc gag ggc cgc aaa agc ttc ccc agc atc cat tcc      846
 Pro Asp Leu Val Ser Glu Gly Arg Lys Ser Phe Pro Ser Ile His Ser
             135                 140                 145

 tcc ttt gcc ttt tcg ggc ctt ggc ttc acg acg ttc tac ttg gcg ggc      894
 Ser Phe Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe Tyr Leu Ala Gly
         150                 155                 160

 aag ctg cac tgc ttc acc gag agt ggg cgg gga aag agc tgg cgg ctc      942
 Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys Ser Trp Arg Leu
     165                 170                 175

 tgt gct gcc atc ctg ccc ttg tac tgc gcc atg atg att gcc ctg tcc      990
 Cys Ala Ala Ile Leu Pro Leu Tyr Cys Ala Met Met Ile Ala Leu Ser
 180                 185                 190                 195

 cgc atg tgc gac tac aag cat cac tgg caa gat tcc ttt gtg ggt gga     1038
 Arg Met Cys Asp Tyr Lys His His Trp Gln Asp Ser Phe Val Gly Gly
                 200                 205                 210

 gtc atc ggc ctc att ttt gca tac att tgc tac aga cag cac tat cct     1086
 Val Ile Gly Leu Ile Phe Ala Tyr Ile Cys Tyr Arg Gln His Tyr Pro
             215                 220                 225

 cct ctg gcc aac aca gct tgc cat aaa ccc tac gtt agt ctg cga gtc     1134
 Pro Leu Ala Asn Thr Ala Cys His Lys Pro Tyr Val Ser Leu Arg Val
         230                 235                 240

 cca gcc tca ctg aag aaa gag gag agg ccc aca gct gac agt gca ccc     1182
 Pro Ala Ser Leu Lys Lys Glu Glu Arg Pro Thr Ala Asp Ser Ala Pro
     245                 250                 255

 agc ttg gct ctg gag ggg atc acc gca ggc ccg gta tga ccagtgtcct      1231
 Ser Leu Ala Leu Glu Gly Ile Thr Ala Gly Pro Val 
 260                 265                 270

 gggaggatgg acactctccc ctgggcacat atgccaccct gacattcata cacactacaa   1291

 acgggttcct gcagcgcccc tcccatccac ccgcccccaa agcaatacca cttctcctcc   1351

 cgctcactgc cgcagatcct ggtcctccaa agccaccgcc cactaatgag gtctccttgt   1411

 cacggctact ctacctccca acccgcgatg aggcccccac accctcctct cccacccctt   1471

 atcacccacg cccagtccag cgactagccc gcgccctcac acgtcaaccc tgccccccca   1531

 caccgaccta ccccgtatga cctaaccacc cgcggcttcc gccgggtcgc gccagctatc   1591

 tgccgcctgc ctnaagttcg cgcccaccct atctgcccat ctctggatag tccacttcct   1651

 ggaccgcgcc cacgtcttag atacgttgca tactaaaccc tactcggcgc ctccgtcgca   1711

 catccacatc tactcttccc cg                                            1733




      <210> 168
      <211> 1683
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(1238)

      <400> 168
 ccgctcacct gcagggcctg ccccgcctgt tctgtgtctt tcctacccgc ttctgtcctg     60

 ctgcacccac cctgtcagag gcagggcgct gcccgcagtg ccccagactt ccccttcctc    120

 cccaggatca acggccaccc cgggaagtcc acgcgcctgg cgggcttgtg gaagctggaa    180

 gaggtcagtc acccccaggc ttcatgccct gtccctgagc cactgctccc ctgaccgtcc    240

 cccaggaccc ctccctgatc tcctcctgtc tggccccgca gtgccacgcc agcggctgc     299                                                                 
 atg atg gac ctc ttc gtg cag atg gcc atc atc atg ggc ctg aag cag      347
 Met Met Asp Leu Phe Val Gln Met Ala Ile Ile Met Gly Leu Lys Gln
   1               5                  10                  15

 acg ctc agc aac tgc gtc gag tac ctg gtc ccg tgg gtg acc cac aag      395
 Thr Leu Ser Asn Cys Val Glu Tyr Leu Val Pro Trp Val Thr His Lys
              20                  25                  30

 tgc cgc tct ctg cgg gcc tcc gag tcc ggg cac ctg ccc cgg gac ccc      443
 Cys Arg Ser Leu Arg Ala Ser Glu Ser Gly His Leu Pro Arg Asp Pro
          35                  40                  45

 gag ctc agg gac tgg cgg cgc aac tac ctt ctg aac ccg gtc aac acc      491
 Glu Leu Arg Asp Trp Arg Arg Asn Tyr Leu Leu Asn Pro Val Asn Thr
      50                  55                  60

 ttc agc ctg ttc gac gag ttc atg gag atg atg atc cag tac ggc ttc      539
 Phe Ser Leu Phe Asp Glu Phe Met Glu Met Met Ile Gln Tyr Gly Phe
  65                  70                  75                  80

 acc acc atc ttc gtg gcc gcc ttc ccg ctg gcg ccg ctg ctc gcg ctc      587
 Thr Thr Ile Phe Val Ala Ala Phe Pro Leu Ala Pro Leu Leu Ala Leu
                  85                  90                  95

 ttc agc aac ctc gtg gag atc cgc ctg gac gcc atc aag atg gtc tgg      635
 Phe Ser Asn Leu Val Glu Ile Arg Leu Asp Ala Ile Lys Met Val Trp
             100                 105                 110

 ttg cag cgg cgc ctg gtg ccg cgc aag gcc aag gac atc ggg acc tgg      683
 Leu Gln Arg Arg Leu Val Pro Arg Lys Ala Lys Asp Ile Gly Thr Trp
         115                 120                 125

 ctg cag gtg ctg gag acc atc ggt gtg ctg gcg gtc att gcc aat ggg      731
 Leu Gln Val Leu Glu Thr Ile Gly Val Leu Ala Val Ile Ala Asn Gly
     130                 135                 140

 atg gtc att gcc ttc aca tct gag ttc atc ccc cga gtg gtc tac aag      779
 Met Val Ile Ala Phe Thr Ser Glu Phe Ile Pro Arg Val Val Tyr Lys
 145                 150                 155                 160

 tac cgc tat agc cca tgc ctg aaa gaa ggc aac tct act gtc gac tgc      827
 Tyr Arg Tyr Ser Pro Cys Leu Lys Glu Gly Asn Ser Thr Val Asp Cys
                 165                 170                 175

 ctc aag ggc tac gtc aac cac agc ctg tcc gtc ttc cac acc aag gac      875
 Leu Lys Gly Tyr Val Asn His Ser Leu Ser Val Phe His Thr Lys Asp
             180                 185                 190

 ttc cag gac cct gat ggg att gag ggc tca gaa aac gtg act ctg tgc      923
 Phe Gln Asp Pro Asp Gly Ile Glu Gly Ser Glu Asn Val Thr Leu Cys
         195                 200                 205

 aga tac agg gac tac cgc aat ccc ccc gat tac aac ttc tcc gag cag      971
 Arg Tyr Arg Asp Tyr Arg Asn Pro Pro Asp Tyr Asn Phe Ser Glu Gln
     210                 215                 220

 ttc tgg ttc ctc ctg gcc atc cgc ctg gcc ttc gtc atc ctc ttt gag     1019
 Phe Trp Phe Leu Leu Ala Ile Arg Leu Ala Phe Val Ile Leu Phe Glu
 225                 230                 235                 240

 cac gtg gcc ttg tgc atc aag ctc atc gcc gcc tgg ttc gtg ccc gac     1067
 His Val Ala Leu Cys Ile Lys Leu Ile Ala Ala Trp Phe Val Pro Asp
                 245                 250                 255

 atc cct cag tcg gtg aag aac aag gtt ctg gag gtg aag tac cag agg     1115
 Ile Pro Gln Ser Val Lys Asn Lys Val Leu Glu Val Lys Tyr Gln Arg
             260                 265                 270

 ctg cgt gag aag atg tgg cat gga agg cag agg ctg ggt ggg gtg ggg     1163
 Leu Arg Glu Lys Met Trp His Gly Arg Gln Arg Leu Gly Gly Val Gly
         275                 280                 285

 gca ggc tct cgg ccc cca atg cct gcc cat ccc acc cca gca tcc atc     1211
 Ala Gly Ser Arg Pro Pro Met Pro Ala His Pro Thr Pro Ala Ser Ile
     290                 295                 300

 ttc agt gcc agg agc aca gac gtg tag ggcca gagcccgtcc agaggccacc     1263
 Phe Ser Ala Arg Ser Thr Asp Val 
 305                 310

 aggagctgag acagtgccac caccagcacc tcccacaagc ccaccgctgt gcgtgttgag   1323

 gggtgctgtg agaaggctgt gcccatgtgg ggccgcagga atcccctgta tgttcagggc   1383

 tgtgagctgc caccctattc cgcctgctcc gtctttgtgg gggctctcag gcttggcaca   1443

 gccctgactt gaactctggg tgaccctggg cacccacaga actgggagtg agggctcctc   1503

 aggcagccac aaggcaggaa aactggcgca aatttcctgg gcctccctct gacttctggg   1563

 cgccagatcc tgccgtgccc gcatcctggc tgttgggggt gtcctgagcc cacctcgctg   1623

 gcctgttccc ttcagccaac ccgtttctgc agtaaaatta agcctgtcaa aaaaaaaaaa   1683




      <210> 169
      <211> 1033
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(769)

      <400> 169
 cctgcagggg ctgctcggcg tcgtggcctt cagcacgtta  atg ctc aaa cgc ttc      55
                                              Met Leu Lys Arg Phe
                                                1               5

 aga gaa cca aag cat gaa aga cgt ccg tgg agg ata tgg ttt tta gac      103
 Arg Glu Pro Lys His Glu Arg Arg Pro Trp Arg Ile Trp Phe Leu Asp
                  10                  15                  20

 act tcc aaa caa gcc ata gga atg ctg ttc atc cac ttt gca aat gta      151
 Thr Ser Lys Gln Ala Ile Gly Met Leu Phe Ile His Phe Ala Asn Val
              25                  30                  35

 tac cta gca gat ctc act gaa gag gac cct tgt tca ctg tac ctc atc      199
 Tyr Leu Ala Asp Leu Thr Glu Glu Asp Pro Cys Ser Leu Tyr Leu Ile
          40                  45                  50

 aac ttc ctc ctg gac gcc act gtg ggc atg ctg ctc atc tac gtg ggg      247
 Asn Phe Leu Leu Asp Ala Thr Val Gly Met Leu Leu Ile Tyr Val Gly
      55                  60                  65

 gtg cgc gcc gtc agc gtc ctg gta gag tgg cag cag tgg gag tcc ctg      295
 Val Arg Ala Val Ser Val Leu Val Glu Trp Gln Gln Trp Glu Ser Leu
  70                  75                  80                  85

 cgc ttc ggc gaa tat gga gac cct ctg cag tgt gga gcc tgg gtc ggg      343
 Arg Phe Gly Glu Tyr Gly Asp Pro Leu Gln Cys Gly Ala Trp Val Gly
                  90                  95                 100

 cag tgc gct ctt tac atc gtg atc atg att ttt gaa aag tct gtc gtc      391
 Gln Cys Ala Leu Tyr Ile Val Ile Met Ile Phe Glu Lys Ser Val Val
             105                 110                 115

 ttc atc gtc ctc cta ata ctt cag tgg aaa aag gtg gcc ctg ttg aat      439
 Phe Ile Val Leu Leu Ile Leu Gln Trp Lys Lys Val Ala Leu Leu Asn
         120                 125                 130

 ccc att gaa aac cca gac ttg aag ctg gcc atc gtc atg ctg atc gtc      487
 Pro Ile Glu Asn Pro Asp Leu Lys Leu Ala Ile Val Met Leu Ile Val
     135                 140                 145

 ccc ttc ttt gtc aac gct ttg atg ttt tgg gta gtg gac aat ttc ctc      535
 Pro Phe Phe Val Asn Ala Leu Met Phe Trp Val Val Asp Asn Phe Leu
 150                 155                 160                 165

 atg aga aag ggg aag acg aaa gct aag cta gaa gaa agg gga gcc aac      583
 Met Arg Lys Gly Lys Thr Lys Ala Lys Leu Glu Glu Arg Gly Ala Asn
                 170                 175                 180

 cag gac tcg agg aat ggg agc aag gtc cgc tac cgg agg gcc gca tcc      631
 Gln Asp Ser Arg Asn Gly Ser Lys Val Arg Tyr Arg Arg Ala Ala Ser
             185                 190                 195

 cac gag gag tct gag tct gag atc ctg atc tca gcg gat gat gag atg      679
 His Glu Glu Ser Glu Ser Glu Ile Leu Ile Ser Ala Asp Asp Glu Met
         200                 205                 210

 gag gag tcc gac gtg gag gag gac ctc cgc aga ctg acc ccc ctc aag      727
 Glu Glu Ser Asp Val Glu Glu Asp Leu Arg Arg Leu Thr Pro Leu Lys
     215                 220                 225

 cct gtg aag aaa aag aag cac cgc ttt ggg cta ccc gta tga cacattc      776
 Pro Val Lys Lys Lys Lys His Arg Phe Gly Leu Pro Val 
 230                 235                 240

 ccatgctggg ggtgacggga gggccccgcc agccgctggt gtgcagaggt catcccacag    836

 catcgttcct taccctctct ctgcccttcc tttctacctc tgctcctctt gctgtctctg    896

 cccgctctcg cctgccccca gactactgtg acttaaaaag agggaagagg agccagcgcc    956

 cgagggggcc actggcggct ggaggtcccc attcagttgc actacaaaca ctgaccaaat   1016

 atgcaaggaa aaaaaaa                                                  1033




      <210> 170
      <211> 1587
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (295)..(1587)

      <400> 170
 gaaaactgaa gccgtcgcat gctcgaccgc ccttgaattg ccgggtcgac gtttcgtctc     60

 aggacgaggg acggggcggc aaattgtcac agaggtcgcc gtataccggt gtgcaaccga    120

 aggtgaagag cgggaaggcg aggaccgaat cgcctctggt gtgcgttgtc cgacaggaag    180

 tcccgaatgg gctgtgagcc gccggtggag gtgcccgggc aggtgcagag ccacagcctg    240

 cgccccgtga gccgaggcgg gtgatttatt tggcataaaa gtattctttc aagg  atg     297
                                                              Met
                                                                1

 gca gaa gct gtt ttg att gat ctt ttt ggt ttg aaa ttg aac tct caa      345
 Ala Glu Ala Val Leu Ile Asp Leu Phe Gly Leu Lys Leu Asn Ser Gln
               5                  10                  15

 aaa aac tgc cat cag aca tta ctg aag act ttg aat gct gtc caa tac      393
 Lys Asn Cys His Gln Thr Leu Leu Lys Thr Leu Asn Ala Val Gln Tyr
          20                  25                  30

 cac cat gct gcc aag gcc aag ttt ctc tgt ata atg tgt tgc agt aac      441
 His His Ala Ala Lys Ala Lys Phe Leu Cys Ile Met Cys Cys Ser Asn
      35                  40                  45

 atc agc tat gaa agg gat gga gaa caa gat aat tgt gaa ata gaa aca      489
 Ile Ser Tyr Glu Arg Asp Gly Glu Gln Asp Asn Cys Glu Ile Glu Thr
  50                  55                  60                  65

 agc aat gga tta tca gct ctc ttg gaa gaa ttt gag att gtt agc tgt      537
 Ser Asn Gly Leu Ser Ala Leu Leu Glu Glu Phe Glu Ile Val Ser Cys
                  70                  75                  80

 ccc agc atg gct gcc act ttg tat acc att aaa cag aaa att gat gaa      585
 Pro Ser Met Ala Ala Thr Leu Tyr Thr Ile Lys Gln Lys Ile Asp Glu
              85                  90                  95

 aaa aat ctg agc agc att aag gta att gta ccc agg cac agg aag aca      633
 Lys Asn Leu Ser Ser Ile Lys Val Ile Val Pro Arg His Arg Lys Thr
         100                 105                 110

 tta atg aaa gct ttt att gat caa ctc ttc act gat gtt tac aat ttt      681
 Leu Met Lys Ala Phe Ile Asp Gln Leu Phe Thr Asp Val Tyr Asn Phe
     115                 120                 125

 gaa ttt gaa gat ttg caa gtg act ttt agg gga ggg ctt ttt aaa cag      729
 Glu Phe Glu Asp Leu Gln Val Thr Phe Arg Gly Gly Leu Phe Lys Gln
 130                 135                 140                 145

 tcc att gaa ata aac gta atc aca gct caa gaa cta aga gga att cag      777
 Ser Ile Glu Ile Asn Val Ile Thr Ala Gln Glu Leu Arg Gly Ile Gln
                 150                 155                 160

 aat gaa ata gaa aca ttt ttg aga agt ctg cca gca ctg aga gga aaa      825
 Asn Glu Ile Glu Thr Phe Leu Arg Ser Leu Pro Ala Leu Arg Gly Lys
             165                 170                 175

 tta act att atc act tct tct ttg atc cca gat att ttc ata cat gga      873
 Leu Thr Ile Ile Thr Ser Ser Leu Ile Pro Asp Ile Phe Ile His Gly
         180                 185                 190

 ttt act aca aga aca ggt ggg ata tct tat ata cca act ctt agc tca      921
 Phe Thr Thr Arg Thr Gly Gly Ile Ser Tyr Ile Pro Thr Leu Ser Ser
     195                 200                 205

 ttc aat ctc ttc agt agt tcc aaa cgg aga gat ccc aag gta gtg gtt      969
 Phe Asn Leu Phe Ser Ser Ser Lys Arg Arg Asp Pro Lys Val Val Val
 210                 215                 220                 225

 caa gaa aat ctg cgt agg ttg gcg aat gct gca gga ttt aat gtg gag     1017
 Gln Glu Asn Leu Arg Arg Leu Ala Asn Ala Ala Gly Phe Asn Val Glu
                 230                 235                 240

 aaa ttt tac cga ata aag act cat cat tcc aat gac atc tgg att atg     1065
 Lys Phe Tyr Arg Ile Lys Thr His His Ser Asn Asp Ile Trp Ile Met
             245                 250                 255

 gga aga aag gag cct gac tct tat gat gga ata acc aca aat cag aga     1113
 Gly Arg Lys Glu Pro Asp Ser Tyr Asp Gly Ile Thr Thr Asn Gln Arg
         260                 265                 270

 gga gtc aca ata gca gct ctt ggt gca gac tgt ata ccg ata gtt ttt     1161
 Gly Val Thr Ile Ala Ala Leu Gly Ala Asp Cys Ile Pro Ile Val Phe
     275                 280                 285

 gca gat cca gtc aaa aaa gca tgt ggg gtt gct cac gct ggt tgg aaa     1209
 Ala Asp Pro Val Lys Lys Ala Cys Gly Val Ala His Ala Gly Trp Lys
 290                 295                 300                 305

 ggt act ttg ttg ggt gtt gct atg gct aca gtg aat gct atg ata gca     1257
 Gly Thr Leu Leu Gly Val Ala Met Ala Thr Val Asn Ala Met Ile Ala
                 310                 315                 320

 gaa tat ggc tgc agt ttg gaa gac att gtt gtt gta ctt gga cct tca     1305
 Glu Tyr Gly Cys Ser Leu Glu Asp Ile Val Val Val Leu Gly Pro Ser
             325                 330                 335

 gta gga cct tgc tgt ttt act ctt cca agg gaa tca gca gag gca ttt     1353
 Val Gly Pro Cys Cys Phe Thr Leu Pro Arg Glu Ser Ala Glu Ala Phe
         340                 345                 350

 cat aat ctt cat cct gca tgt gta caa cta ttt gat tca cca aat ccc     1401
 His Asn Leu His Pro Ala Cys Val Gln Leu Phe Asp Ser Pro Asn Pro
     355                 360                 365

 tgt atc gac atc cgt aaa gcc aca agg att ctt cta gaa cag gga gga     1449
 Cys Ile Asp Ile Arg Lys Ala Thr Arg Ile Leu Leu Glu Gln Gly Gly
 370                 375                 380                 385

 att ctt cca cag aat att cag gac cag aac caa gat ctc aac ctc tgt     1497
 Ile Leu Pro Gln Asn Ile Gln Asp Gln Asn Gln Asp Leu Asn Leu Cys
                 390                 395                 400

 aca tct tgc cat cct gac aag ttt ttc tcc cat gtc cga gat ggc ctt     1545
 Thr Ser Cys His Pro Asp Lys Phe Phe Ser His Val Arg Asp Gly Leu
             405                 410                 415

 aat ttt ggt aca cag att ggc ttc ata tca att aaa gaa tga             1587
 Asn Phe Gly Thr Gln Ile Gly Phe Ile Ser Ile Lys Glu 
         420                 425                 430





      <210> 171
      <211> 877
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(786)

      <400> 171
 gggtggaatt cgggcagcct gcgcctgggt accgaggctg ctgcgcggcg gacagcgggc     60

 gcg  atg tat ctc cgc agg gcg gtc tcc aag act ctg gcg ctg ccg ctg     108
      Met Tyr Leu Arg Arg Ala Val Ser Lys Thr Leu Ala Leu Pro Leu
        1               5                  10                  15

 agg gcg ccc ccc aac ccc gcg ccg ctc gga aag gac gca tct ctg cgc      156
 Arg Ala Pro Pro Asn Pro Ala Pro Leu Gly Lys Asp Ala Ser Leu Arg
                  20                  25                  30

 cgg atg tca tct aac aga ttc cct gga tca tct gga tca aat atg att      204
 Arg Met Ser Ser Asn Arg Phe Pro Gly Ser Ser Gly Ser Asn Met Ile
              35                  40                  45

 tat tat ctg gtt gta ggc gtc aca gtc agt gct ggt gga tat tat gct      252
 Tyr Tyr Leu Val Val Gly Val Thr Val Ser Ala Gly Gly Tyr Tyr Ala
          50                  55                  60

 tac aag aca gtc aca tca gac caa gcc aaa cac aca gaa cat aaa aca      300
 Tyr Lys Thr Val Thr Ser Asp Gln Ala Lys His Thr Glu His Lys Thr
      65                  70                  75

 aat ttg aaa gaa aaa aca aaa gca gag ata cat cca ttt caa ggt gaa      348
 Asn Leu Lys Glu Lys Thr Lys Ala Glu Ile His Pro Phe Gln Gly Glu
  80                  85                  90                  95

 aag gag aat gtt gcg gaa act gag aaa gca agt tca gaa gcc cca gaa      396
 Lys Glu Asn Val Ala Glu Thr Glu Lys Ala Ser Ser Glu Ala Pro Glu
                 100                 105                 110

 gaa ctt ata gtg gaa gct gag gtg gta gat gct gaa gaa agt ccc agt      444
 Glu Leu Ile Val Glu Ala Glu Val Val Asp Ala Glu Glu Ser Pro Ser
             115                 120                 125

 gct aca gtt gtg gtc ata aaa gag gca tct gcc tgt cca ggt cac gtg      492
 Ala Thr Val Val Val Ile Lys Glu Ala Ser Ala Cys Pro Gly His Val
         130                 135                 140

 gag gct gct ccg gag acc aca gca gtc agt gct gaa acc ggg cca gag      540
 Glu Ala Ala Pro Glu Thr Thr Ala Val Ser Ala Glu Thr Gly Pro Glu
     145                 150                 155

 gtc aca gat gca gcg gcg agg gaa acc acg gaa gta aac cct gaa aca      588
 Val Thr Asp Ala Ala Ala Arg Glu Thr Thr Glu Val Asn Pro Glu Thr
 160                 165                 170                 175

 acc cca gag gtt aca aat gct gcc ctg gat gaa gct gtc acc atc gat      636
 Thr Pro Glu Val Thr Asn Ala Ala Leu Asp Glu Ala Val Thr Ile Asp
                 180                 185                 190

 aat gat aaa gat aca aca aag aac gaa acc tct gat gaa tat gct gaa      684
 Asn Asp Lys Asp Thr Thr Lys Asn Glu Thr Ser Asp Glu Tyr Ala Glu
             195                 200                 205

 cta gaa gaa gaa aat tct cca gct gag tca gag tcc tct gct gga gat      732
 Leu Glu Glu Glu Asn Ser Pro Ala Glu Ser Glu Ser Ser Ala Gly Asp
         210                 215                 220

 gat tta cag gag gaa gcc agt gtt ggc tct gag gct gct tcg gct caa      780
 Asp Leu Gln Glu Glu Ala Ser Val Gly Ser Glu Ala Ala Ser Ala Gln
     225                 230                 235

 ggc taa tctccagccg gtagacattt cagcaacaaa tgccataggg tgtctgataa       836
 Gly 
 240

 gtgcttttgt gtttttagta cacttagttt aaaaaaaaaa a                        877




      <210> 172
      <211> 1289
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (166)..(1158)

      <400> 172
 gggtcataat ccctaactcc aatcactggc aactcctgag atcagaggcc agcaacagcg     60

 tgggagtttg gggagaggca ttccatacca gattctgtgg cctgcaggtg acatgctgcc    120

 taagagaagc aggagtctgt gacagccacc ccaacacgtg acgtc    atg gcc agt     174
                                                      Met Ala Ser
                                                        1

 agg gaa gat gag ctg agg aac tgt gtg gta tgt ggg gac caa gcc aca      222
 Arg Glu Asp Glu Leu Arg Asn Cys Val Val Cys Gly Asp Gln Ala Thr
       5                  10                  15

 ggc tac cac ttt aat gcg ctg act tgt gag ggc tgc aag ggt ttc ttc      270
 Gly Tyr His Phe Asn Ala Leu Thr Cys Glu Gly Cys Lys Gly Phe Phe
  20                  25                  30                  35

 agg aga aca gtc agc cag agg cgc cac tgc cca gcc tgc agg ttg cag      318
 Arg Arg Thr Val Ser Gln Arg Arg His Cys Pro Ala Cys Arg Leu Gln
                  40                  45                  50

 aag tgc tta gat gct ggc atg agg aaa gac atg ata ctg tcg gca gaa      366
 Lys Cys Leu Asp Ala Gly Met Arg Lys Asp Met Ile Leu Ser Ala Glu
              55                  60                  65

 gcc ctg gca ttg cgg cga gca aag cag gcc cag cgg cgg gca cag caa      414
 Ala Leu Ala Leu Arg Arg Ala Lys Gln Ala Gln Arg Arg Ala Gln Gln
          70                  75                  80

 aca cct gtg caa ctg agt aag gag caa gaa gag ctg atc cgg aca ctc      462
 Thr Pro Val Gln Leu Ser Lys Glu Gln Glu Glu Leu Ile Arg Thr Leu
      85                  90                  95

 ctg ggg gcc cac acc cgc cac atg ggc acc atg ttt gaa cag ttt gtg      510
 Leu Gly Ala His Thr Arg His Met Gly Thr Met Phe Glu Gln Phe Val
 100                 105                 110                 115

 cag ttt agg cct cca gct cat ctg ttc atc cat cac cag ccc ttg ccc      558
 Gln Phe Arg Pro Pro Ala His Leu Phe Ile His His Gln Pro Leu Pro
                 120                 125                 130

 acc ctg gcc cct gtg ctg cct ctg gtc aca cac ttt gca gac atc aac      606
 Thr Leu Ala Pro Val Leu Pro Leu Val Thr His Phe Ala Asp Ile Asn
             135                 140                 145

 act ttc atg gta ctg caa gtc atc aag ttt act aag gac ctg ccc gtc      654
 Thr Phe Met Val Leu Gln Val Ile Lys Phe Thr Lys Asp Leu Pro Val
         150                 155                 160

 ttc cgt tcc ctg ccc att gaa gac cag atc tcc ctt ctc aag gga gca      702
 Phe Arg Ser Leu Pro Ile Glu Asp Gln Ile Ser Leu Leu Lys Gly Ala
     165                 170                 175

 gct gtg gaa atc tgt cac atc gta ctc aat acc act ttc tgt ctc caa      750
 Ala Val Glu Ile Cys His Ile Val Leu Asn Thr Thr Phe Cys Leu Gln
 180                 185                 190                 195

 aca caa aac ttc ctc tgc ggg cct ctt cgc tac aca att gaa gat gga      798
 Thr Gln Asn Phe Leu Cys Gly Pro Leu Arg Tyr Thr Ile Glu Asp Gly
                 200                 205                 210

 gcc cgt gtg ggg ttc cag gta gag ttt ttg gag ttg ctc ttt cac ttc      846
 Ala Arg Val Gly Phe Gln Val Glu Phe Leu Glu Leu Leu Phe His Phe
             215                 220                 225

 cat gga aca cta cga aaa ctg cag ctc caa gag cct gag tat gtg ctc      894
 His Gly Thr Leu Arg Lys Leu Gln Leu Gln Glu Pro Glu Tyr Val Leu
         230                 235                 240

 ttg gct gcc atg gcc ctc ttc tct cct gac cga cct gga gtt acc cag      942
 Leu Ala Ala Met Ala Leu Phe Ser Pro Asp Arg Pro Gly Val Thr Gln
     245                 250                 255

 aga gat gag att gat cag ctg caa gag gag atg gca ctg act ctg caa      990
 Arg Asp Glu Ile Asp Gln Leu Gln Glu Glu Met Ala Leu Thr Leu Gln
 260                 265                 270                 275

 agc tac atc aag ggc cag cag cga agg ccc cgg gat cgg ttt ctg tat     1038
 Ser Tyr Ile Lys Gly Gln Gln Arg Arg Pro Arg Asp Arg Phe Leu Tyr
                 280                 285                 290

 gcg aag ttg cta ggc ctg ctg gct gag ctc cgg agc att aat gag gcc     1086
 Ala Lys Leu Leu Gly Leu Leu Ala Glu Leu Arg Ser Ile Asn Glu Ala
             295                 300                 305

 tac ggg tac caa atc cag cac atc cag ggc ctg tct gcc atg atg ccg     1134
 Tyr Gly Tyr Gln Ile Gln His Ile Gln Gly Leu Ser Ala Met Met Pro
         310                 315                 320

 ctg ctc cag gag atc tgc agc tga ggccatgctc acttccttcc ccagctcacc    1188
 Leu Leu Gln Glu Ile Cys Ser 
     325                 330

 tggaacaccc tggatacact ggagtgggaa aatgctggga ccaaagattg ggccgggttc   1248

 aaagggagcc cagtggttgc aatgaaagac taaagcaaaa c                       1289




      <210> 173
      <211> 5130
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(2013)

      <400> 173
 tcctttaaag caagaaagga gcaggtagat gatggagact tagagaggca gaaagaatgg     60

 acaggctttg gtaaccagat ggaaataaat agtaaatgta acggaaagag ccagggctcg    120

 gaggtactga aggtggtcgc c  atg gat gga gac cgg ggc aaa ccc aat cga     171
                          Met Asp Gly Asp Arg Gly Lys Pro Asn Arg
                            1               5                  10

 att ctc tac agc ctt gta aat gac ttc cct agt gca atg cag gag ggc      219
 Ile Leu Tyr Ser Leu Val Asn Asp Phe Pro Ser Ala Met Gln Glu Gly
                  15                  20                  25

 tcg gag gta ctg aag gtg gtc gcc atg gat gga gac cgg ggc aaa ccc      267
 Ser Glu Val Leu Lys Val Val Ala Met Asp Gly Asp Arg Gly Lys Pro
              30                  35                  40

 aat cga att ctc tac agc ctt gta aat ggg aac gat gga gcc ttt gaa      315
 Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly Asn Asp Gly Ala Phe Glu
          45                  50                  55

 att aat gag aca tct gga gcc atc tcc atc act cag agc ccg gcc cag      363
 Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile Thr Gln Ser Pro Ala Gln
      60                  65                  70

 ctc cag aga gag gtg tat gag ctg cat gta cag gtg act gaa atg agc      411
 Leu Gln Arg Glu Val Tyr Glu Leu His Val Gln Val Thr Glu Met Ser
  75                  80                  85                  90

 cct gcg ggg agc cca gct gcc cag gcc acc gtc cca gtc acc atc agg      459
 Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr Val Pro Val Thr Ile Arg
                  95                 100                 105

 att gtg gac ctc aac aac cac ccg cca aca ttc tat gga gag agc gga      507
 Ile Val Asp Leu Asn Asn His Pro Pro Thr Phe Tyr Gly Glu Ser Gly
             110                 115                 120

 ccc caa aac agg ttt gag ctg tcc atg aat gag cac cca ccc cag gga      555
 Pro Gln Asn Arg Phe Glu Leu Ser Met Asn Glu His Pro Pro Gln Gly
         125                 130                 135

 gag atc ctg cgg ggc ctc aag atc acc gtc aat gac tcc gac cag gga      603
 Glu Ile Leu Arg Gly Leu Lys Ile Thr Val Asn Asp Ser Asp Gln Gly
     140                 145                 150

 gcc aat gcc aaa ttc aac ttg cag ctg gtg gga ccc agg ggc atc ttc      651
 Ala Asn Ala Lys Phe Asn Leu Gln Leu Val Gly Pro Arg Gly Ile Phe
 155                 160                 165                 170

 cga gtg gtt cca cag aca gtc ctg aat gaa gcc caa gtc aca atc att      699
 Arg Val Val Pro Gln Thr Val Leu Asn Glu Ala Gln Val Thr Ile Ile
                 175                 180                 185

 gtg gag aac tca gct gcc att gac ttt gaa aag tcc aaa gta tta acc      747
 Val Glu Asn Ser Ala Ala Ile Asp Phe Glu Lys Ser Lys Val Leu Thr
             190                 195                 200

 ttc aag ctc ctg gct gtt gaa gtg aac acc cca gag aag ttc agt tcc      795
 Phe Lys Leu Leu Ala Val Glu Val Asn Thr Pro Glu Lys Phe Ser Ser
         205                 210                 215

 aca gcg gat gtt gtg atc cag ctc ctg gac acc aat gac aat gtc ccc      843
 Thr Ala Asp Val Val Ile Gln Leu Leu Asp Thr Asn Asp Asn Val Pro
     220                 225                 230

 aag ttc gac tcc ctc tac tac gtt gcc agg att cct gag aac gcc cca      891
 Lys Phe Asp Ser Leu Tyr Tyr Val Ala Arg Ile Pro Glu Asn Ala Pro
 235                 240                 245                 250

 ggg ggc tcc agc gtg gtg gct gtc aca gct gtg gat cca gat aca gga      939
 Gly Gly Ser Ser Val Val Ala Val Thr Ala Val Asp Pro Asp Thr Gly
                 255                 260                 265

 ccc tgg ggc gaa gtg aaa tat tcc acc tat ggg act ggg gca gac ctc      987
 Pro Trp Gly Glu Val Lys Tyr Ser Thr Tyr Gly Thr Gly Ala Asp Leu
             270                 275                 280

 ttc ctg atc cac cca tcc act ggg ctt atc tac acc cag ccc tgg gct     1035
 Phe Leu Ile His Pro Ser Thr Gly Leu Ile Tyr Thr Gln Pro Trp Ala
         285                 290                 295

 agc ctg gac gct gag gcc act gcc agg tac aac ttc tat gtg aag gca     1083
 Ser Leu Asp Ala Glu Ala Thr Ala Arg Tyr Asn Phe Tyr Val Lys Ala
     300                 305                 310

 gag gac atg gaa ggc aag tac agc gta gct gag gtg ttt atc aca ctg     1131
 Glu Asp Met Glu Gly Lys Tyr Ser Val Ala Glu Val Phe Ile Thr Leu
 315                 320                 325                 330

 ctg gat gtc aat gac cac ccc cct cag ttt gga aag agc gtt cag aag     1179
 Leu Asp Val Asn Asp His Pro Pro Gln Phe Gly Lys Ser Val Gln Lys
                 335                 340                 345

 aag acg atg gtg cta ggg acc cca gtg aaa att gag gcc ata gac gag     1227
 Lys Thr Met Val Leu Gly Thr Pro Val Lys Ile Glu Ala Ile Asp Glu
             350                 355                 360

 gat gca gag gaa ccc aac aac ctg gtg gac tat tcc atc acc cat gca     1275
 Asp Ala Glu Glu Pro Asn Asn Leu Val Asp Tyr Ser Ile Thr His Ala
         365                 370                 375

 gag ccc gcc aac gtg ttc gac atc aat tcc cac acg ggg gag atc tgg     1323
 Glu Pro Ala Asn Val Phe Asp Ile Asn Ser His Thr Gly Glu Ile Trp
     380                 385                 390

 ctc aag aat tcc atc cgc tcc ctg gat gcc ctg cac aac atc aca cct     1371
 Leu Lys Asn Ser Ile Arg Ser Leu Asp Ala Leu His Asn Ile Thr Pro
 395                 400                 405                 410

 gga agg gac tgc cta tgg tcc cta gag gtg cag gcc aag gac cgg ggc     1419
 Gly Arg Asp Cys Leu Trp Ser Leu Glu Val Gln Ala Lys Asp Arg Gly
                 415                 420                 425

 tcc cca tcc ttc agc acc aca gcc tta ctc aag att gac atc aca gat     1467
 Ser Pro Ser Phe Ser Thr Thr Ala Leu Leu Lys Ile Asp Ile Thr Asp
             430                 435                 440

 gct gag acc ctc tcc cgg agc ccc atg gct gcc ttc ctg ata cag acc     1515
 Ala Glu Thr Leu Ser Arg Ser Pro Met Ala Ala Phe Leu Ile Gln Thr
         445                 450                 455

 aag gac aac ccc atg aag gcc gtg ggt gtg ctg gcc ggc acc atg gcc     1563
 Lys Asp Asn Pro Met Lys Ala Val Gly Val Leu Ala Gly Thr Met Ala
     460                 465                 470

 acc gtc gtg gcc atc act gtc ctc atc tcc acc gcc acc ttc tgg cgc     1611
 Thr Val Val Ala Ile Thr Val Leu Ile Ser Thr Ala Thr Phe Trp Arg
 475                 480                 485                 490

 aac aag aag tct aac aag gtc ctg cca atg cgg cgg gtg ctc cgc aag     1659
 Asn Lys Lys Ser Asn Lys Val Leu Pro Met Arg Arg Val Leu Arg Lys
                 495                 500                 505

 cgg ccc agc cct gcg ccc cgc acc atc cgc att gag tgg ctc aag tcc     1707
 Arg Pro Ser Pro Ala Pro Arg Thr Ile Arg Ile Glu Trp Leu Lys Ser
             510                 515                 520

 aag agc acc aaa gcc gct acc aag ttc atg ctc aaa gag aaa cct ccc     1755
 Lys Ser Thr Lys Ala Ala Thr Lys Phe Met Leu Lys Glu Lys Pro Pro
         525                 530                 535

 aat gag aac tgt aac aac aac agc cca gaa agc tct ctg ctc ccg aga     1803
 Asn Glu Asn Cys Asn Asn Asn Ser Pro Glu Ser Ser Leu Leu Pro Arg
     540                 545                 550

 gct ccg gct ctc cct cca cca ccc agc gtg gcg ccc agc act ggc gca     1851
 Ala Pro Ala Leu Pro Pro Pro Pro Ser Val Ala Pro Ser Thr Gly Ala
 555                 560                 565                 570

 gcc cag tgg acc gtg cct act gtc tct ggc tct ctc act ccg cag ccg     1899
 Ala Gln Trp Thr Val Pro Thr Val Ser Gly Ser Leu Thr Pro Gln Pro
                 575                 580                 585

 acc caa ccc ccg cca aaa ccc aaa act atg gga agc ccc gtc cag tca     1947
 Thr Gln Pro Pro Pro Lys Pro Lys Thr Met Gly Ser Pro Val Gln Ser
             590                 595                 600

 act ctg atc tct gag ctc aag caa aag ttt gag aag aag agt gtg cac     1995
 Thr Leu Ile Ser Glu Leu Lys Gln Lys Phe Glu Lys Lys Ser Val His
         605                 610                 615

 aac aag gct tac ttc tag tgtatg ccctatgacc ccccatcttt cctccgcccc     2049
 Asn Lys Ala Tyr Phe 
     620

 tgacccccac caccctgctg ctcggactat gctccccttc ctctgctcct taaggtcact   2109

 gacccctgtt ttgcacaatg gtataatccc cactgtcctc atctctaccg ccaccttctg   2169

 gcgcaacaag aagttgcgct ctgacagggc tctagtcagg gccttgggca agacattggg   2229

 ctctaggatg caattggcaa atacgtcccc gttactcaaa tccttggcac tactacaatg   2289

 ccctccattc ttcagggctg agaattgacg agaagccagc tcacccatcc cagacctcac   2349

 agtccctcag gttctactgg gatctcatca tcatccttag tcaagcagca gggccctggc   2409

 cacgtggagc aacactgact agaatctgga tcctgacgcc tgcagctgag agcaggagca   2469

 ggaaaaggag gctcagcact gtctcaggct ggaggtcagc gaacctcgtg ggctgtagga   2529

 aagcaaatgt aggtaagggg agagcaagga tgcacagaaa acacactgac tgtgggactg   2589

 tgccaggatg catttggaaa gatagagcat tctgtctggg cagagactgt ggaccctggt   2649

 atgcccacgt gggacagagg acacagaggt ggaagattga tcttgccaag agtgagggca   2709

 gatgtctcca gccaggactg ccctgagccg caaaatgtca aagctggagc tatagaggta   2769

 gccctaaagg caactagaag agcatcaggg ctgctctctg aggagctgcc ccaccagcca   2829

 tccttgaaga gacaattcag ggcagttgat gaatatcagg gctgagatgt ggggagactt   2889

 ccgtttttat ccagctcttt tgctcacatc gcgtaacctt gggaaagctg tttaaagtcg   2949

 ctgatcatcc tcttcctcat ctgtaaatga agaaagtagg ccctgtctac ctcacatgca   3009

 ggtctagggt gaggattgaa gaaaatagtg gtgatgaggg ctttaaccaa gtgcaaagcg   3069

 gcatgaatgc aaagtatttt tctgcagccc agttctgtgg gtgcagctct tccagaaagt   3129

 attaggagcc tcacatctac tctgccaagc gccccagcag gcactgtgct gggcttaggg   3189

 gctaccactg gatgatggca ttgccgtgac tcacacacct ctacttctgt tcttccctca   3249

 ctccatcccc gctaccgtcc tggccagcta ccgtcagaga gaaccagagc tccaagtctt   3309

 taatttgcca agatgaagaa aatgagttct caaggaggga atgctttgct tgaggccaca   3369

 cagcaggttg gtagcaaaga tcttgtctag ccagggcagc ccttatcagc ttgtgacaac   3429

 cttccccagg acagaagtca tacaaggcct ctggggttaa tacaaatagg ttgtgccctg   3489

 ctttaaggaa cctgctatca ggaaatctac atgtgtgcac agagagagaa aagtagaaca   3549

 gttctttgca tttggctcta cttactaaca acccctctag aatacattgg tgatttcatt   3609

 taaagagatt gtatgcattt gtggctttcc tgatttctga gtctgtgttt ggaggtgtta   3669

 ctgagatgtg ccagtgtgca gaatccttgc tggggtttct acagtcccca acgtgaacag   3729

 tattaagcaa gaggtggact cgagcaatcc aggagcccag actgagcaaa taagtacttt   3789

 ccagcctgtg tttcaggaga ggactgtgct ggatcatgct tgccctccac agggaataca   3849

 gcatccttac agcttgcatg caatcaacct cttttgtaaa tggaaaataa agtctgttac   3909

 ccaaaggcca tgctgatccc ctgctccctg ctttcattta tgtttgctga cctgtggaga   3969

 ccagtctttc tgacacacag tgaagctcaa cttgcctcct ggctgcttca gcaggtggat   4029

 ccattcttcg acccccagat gtgactctaa agaaggctga aaatttttgt ccaaattgcc   4089

 atgcagatat cttgaacagc aggacatttg caggccttgt ctactggact tttctcccaa   4149

 acaggacaag cccaggcagg gctgcatgga gaggaatgga acctggagct agaattaatt   4209

 gcccactctc ccaccctacc agtgcagccc ggcaagggca ggaattggga ggcctagggt   4269

 gggcatgaaa gcttgggaag cactgtcgtc tctcagacag gcgtcctaaa gacctctagg   4329

 ctggaagctt gggcttgcaa gtggatccgg gaccgagggt ggtctcttgg acaaccccag   4389

 gaacttggac caaggcagag ccaatcttgc aaactggcca tggatgggga agtgcccggt   4449

 agccagcatg agccacacta ggaaagagga ggagggtgca gccaaactta aggcaccggc   4509

 aagtgttgtc agcactggag gagaccccgc cagtggggtg aggccagcca agtccctgtg   4569

 ttacgaatgg tgggccaagg ggctgtctgc tcggtcccag taggacaggc agagctccag   4629

 gctggcacca tggtaggcct ccagggaaag agctgggagg caggaatggc acactgggca   4689

 ggcttgccca ttcctggccc tgagaatgga gctgtagcct catggacaat aaatggatgt   4749

 gacaccaaat actctgcaga gtcattttcc tcctgcggct gagctcagat cttccaatca   4809

 catgaaataa caaagtcctt tacagtttga cagccctagg tctgaattct ggttctgcca   4869

 ttaattgtga cttcgggcac agaggtcacg tctctctggg cctcacttac ctcattaaca   4929

 cagggtgcac agtatggttt gcagagagga tgacaagatc taactatatg taccagtgcc   4989

 taagcaaaac gagcattagt actctaccat aacaacacag ctacaaggca gagcctatgc   5049

 acgaggactg ggggacccag aatacataga acagcacgat acctgaaacg agaggaaccc   5109

 ccaacatgaa tcctcaacac c                                             5130




      <210> 174
      <211> 1368
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(1331)

      <400> 174
 agaccctagt cagagtggtg gaattcctcc agcggaggag ctctgggaca cccttgtcta     60

 gggaagaggt cttactggct gccctcacct gactttgtgt ccccaggccc ccagcc        116                                                                 
 atg gcc ctg tcc ctg cct ctg ggc cct aga ctt ggc tca gag ccc ctc      164
 Met Ala Leu Ser Leu Pro Leu Gly Pro Arg Leu Gly Ser Glu Pro Leu
   1               5                  10                  15

 aac cac cca ccg gga gca cct aga gag gcg gac att gtt gga tgc acc      212
 Asn His Pro Pro Gly Ala Pro Arg Glu Ala Asp Ile Val Gly Cys Thr
              20                  25                  30

 gtc tgc ccc gcg tcc gga gag gag agc acg agc cca gag cag gcc cag      260
 Val Cys Pro Ala Ser Gly Glu Glu Ser Thr Ser Pro Glu Gln Ala Gln
          35                  40                  45

 acc ctg gga cag gac tcc ttg ggc cct cct gag cac ttc cag ggt ggg      308
 Thr Leu Gly Gln Asp Ser Leu Gly Pro Pro Glu His Phe Gln Gly Gly
      50                  55                  60

 cca agg ggc aat gag cct gcc gct cac ccc ccg aga tgg tca aca ccc      356
 Pro Arg Gly Asn Glu Pro Ala Ala His Pro Pro Arg Trp Ser Thr Pro
  65                  70                  75                  80

 tct tcc tac gag gac cca gct ggg ggc aaa cac tgt gag cac ccc att      404
 Ser Ser Tyr Glu Asp Pro Ala Gly Gly Lys His Cys Glu His Pro Ile
                  85                  90                  95

 tct ggc ctg gag gta cta gag gct gag cag aac agc ctg cac ctg tgc      452
 Ser Gly Leu Glu Val Leu Glu Ala Glu Gln Asn Ser Leu His Leu Cys
             100                 105                 110

 ctg ctg ggg ctg ggc cgc cgg ctg cag gac ctg gag caa ggc ctg ggg      500
 Leu Leu Gly Leu Gly Arg Arg Leu Gln Asp Leu Glu Gln Gly Leu Gly
         115                 120                 125

 cac tgg gca ttg gcc cag agt ggg atg gtg cag ctg cag gcc ctc cag      548
 His Trp Ala Leu Ala Gln Ser Gly Met Val Gln Leu Gln Ala Leu Gln
     130                 135                 140

 gtg gac cta cga ggg gca gct gag cgt gtg gag gcg ctg cta gcg ttt      596
 Val Asp Leu Arg Gly Ala Ala Glu Arg Val Glu Ala Leu Leu Ala Phe
 145                 150                 155                 160

 ggt gag ggg ctg gca cag cgg agt gag ccc agg gcc tgg gca gcc ctg      644
 Gly Glu Gly Leu Ala Gln Arg Ser Glu Pro Arg Ala Trp Ala Ala Leu
                 165                 170                 175

 gag cag atc ctg cgg gcc ctg gga gct tac cga gac tcc atc ttc cgg      692
 Glu Gln Ile Leu Arg Ala Leu Gly Ala Tyr Arg Asp Ser Ile Phe Arg
             180                 185                 190

 cgg ctc tgg cag ctg cag gcc cag ctg gtc agc tac agc ctg gtg ttc      740
 Arg Leu Trp Gln Leu Gln Ala Gln Leu Val Ser Tyr Ser Leu Val Phe
         195                 200                 205

 gag gag gcc aac acg ctg gac cag gac ttg gag gtc gag gga gac tcg      788
 Glu Glu Ala Asn Thr Leu Asp Gln Asp Leu Glu Val Glu Gly Asp Ser
     210                 215                 220

 gac tgg cca gga cct ggt ggg gtc tgg ggg ccc tgg gca ccc agt agc      836
 Asp Trp Pro Gly Pro Gly Gly Val Trp Gly Pro Trp Ala Pro Ser Ser
 225                 230                 235                 240

 ctc ccc act tcc aca gag ttg gag tgg gat ccg gcg ggg gac att ggg      884
 Leu Pro Thr Ser Thr Glu Leu Glu Trp Asp Pro Ala Gly Asp Ile Gly
                 245                 250                 255

 ggc ctt ggg ccc ttg gga caa aag aca gcc cgg aca cta gga gtg ccc      932
 Gly Leu Gly Pro Leu Gly Gln Lys Thr Ala Arg Thr Leu Gly Val Pro
             260                 265                 270

 tgt gag ctg tgt ggc cac agg ggg ccc cag ggc agg gga caa ggc ctt      980
 Cys Glu Leu Cys Gly His Arg Gly Pro Gln Gly Arg Gly Gln Gly Leu
         275                 280                 285

 gag gaa gca gac acc tct cac tcc cga cag gac atg ctg gag tct ggc     1028
 Glu Glu Ala Asp Thr Ser His Ser Arg Gln Asp Met Leu Glu Ser Gly
     290                 295                 300

 ctc ggc cac cag aaa cgc tta gca cgt cac caa aga cac tcc ctg ctc     1076
 Leu Gly His Gln Lys Arg Leu Ala Arg His Gln Arg His Ser Leu Leu
 305                 310                 315                 320

 cgg aag cct cag gac aag aag agg caa gca tct cct cat ctc cag gat     1124
 Arg Lys Pro Gln Asp Lys Lys Arg Gln Ala Ser Pro His Leu Gln Asp
                 325                 330                 335

 gtg agg ctg gag ggg aat cca ggg gcc ccc gat cct gca tcc agg cag     1172
 Val Arg Leu Glu Gly Asn Pro Gly Ala Pro Asp Pro Ala Ser Arg Gln
             340                 345                 350

 cct ctg acc ttc ctc ctt atc ctc ttc ctc ctc ttc ctc ctc ctg gtg     1220
 Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu Leu Phe Leu Leu Leu Val
         355                 360                 365

 ggt gcc atg ttt ctc ctg ccc gcg tca gga ggc ccc tgc tgc tct cat     1268
 Gly Ala Met Phe Leu Leu Pro Ala Ser Gly Gly Pro Cys Cys Ser His
     370                 375                 380

 gcc cga ata ccc agg aca ccc tac ctg gtg ctc agc tat gtc aat ggt     1316
 Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val Leu Ser Tyr Val Asn Gly
 385                 390                 395                 400

 ctt ccc cca gtc tga tgtgtgtaat aaatggtcac tgtcaaaaaa aaaaaaa        1368
 Leu Pro Pro Val 






      <210> 175
      <211> 1336
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (595)..(1191)

      <400> 175
 atgggctggg gggggtcacg tcttgatgat tcttatgcaa acgacctgat ggaagaatgt     60

 gggagctttc ggtgtctgcg gtgggtgtcg gaccaggcgg tccccacttc caccctgcac    120

 cccttcttcc ccccctgcac catgaacacc aatgtctgcg tggagcccgg gccgagcccg    180

 gaggccccgg gcttgcccaa ggaaagccac ttgcccgagg gggctctgaa cagccttgtg    240

 gattacaact cggaaatgga gcgctaccgc tcctttgcca cctccttcta caagaccaac    300

 gggggcgcct tcccacaggc ggccaagatc gcgcgcatca ccacccccat cttccccagc    360

 agcgccgccg ccgccgcggc cgccgcgcgc atcggcatgt ccccctggaa ctgcgacaac    420

 gcggccaccg ccgccgccgc caccgccatg ctctggggca gcggcggggg cgggggcggc    480

 ggcgggcggg ggaaatcctc ctccgccgcc gcctcctcct ccgcctcctc ctcctcggcg    540

 atcctccccg ccggcggtgg cggcggcggc ggcggcggcg gcagcaggac cagc  atg     597
                                                              Met
                                                                1

 cac cac cga aac gac tcc cag agg ctg ggg aaa gct ggc tgc ccg cca      645
 His His Arg Asn Asp Ser Gln Arg Leu Gly Lys Ala Gly Cys Pro Pro
               5                  10                  15

 gag ccg tcg ttg caa atg gca aat act aat ttc ctc tcc acc tta tcc      693
 Glu Pro Ser Leu Gln Met Ala Asn Thr Asn Phe Leu Ser Thr Leu Ser
          20                  25                  30

 cct gaa cac tgc aga cct ttg gcg ggg gaa tgc atg aac aag ctc aaa      741
 Pro Glu His Cys Arg Pro Leu Ala Gly Glu Cys Met Asn Lys Leu Lys
      35                  40                  45

 tgc ggc gct gct gaa gca gag ata atg aat ctc ccc gag cgc gtg ggg      789
 Cys Gly Ala Ala Glu Ala Glu Ile Met Asn Leu Pro Glu Arg Val Gly
  50                  55                  60                  65

 act ttt tcc gct atc ccg gct tta ggg ggc atc tca tta cct cca ggg      837
 Thr Phe Ser Ala Ile Pro Ala Leu Gly Gly Ile Ser Leu Pro Pro Gly
                  70                  75                  80

 gtc atc gtc atg aca gcc ctt cac tcc ccc gca gca gcc tca gca gcc      885
 Val Ile Val Met Thr Ala Leu His Ser Pro Ala Ala Ala Ser Ala Ala
              85                  90                  95

 gtc aca gac agt gcg ttt caa att gcc aat ctg gca gac tgc ccg cag      933
 Val Thr Asp Ser Ala Phe Gln Ile Ala Asn Leu Ala Asp Cys Pro Gln
         100                 105                 110

 aat cat tcc tcc tcc tcc tcg tcc tcc tca ggg gga gct ggc gga gcc      981
 Asn His Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Ala Gly Gly Ala
     115                 120                 125

 aac cca gcc aag aag aag agg aaa agg tgt ggg gtc tgc gtg ccc tgc     1029
 Asn Pro Ala Lys Lys Lys Arg Lys Arg Cys Gly Val Cys Val Pro Cys
 130                 135                 140                 145

 aag agg ctc atc aac tgt ggc gtc tgc agc agt tgc agg aac cgc aaa     1077
 Lys Arg Leu Ile Asn Cys Gly Val Cys Ser Ser Cys Arg Asn Arg Lys
                 150                 155                 160

 acg gga cac cag atc tgc aaa ttt aga aaa tgt gaa gag cta aag aaa     1125
 Thr Gly His Gln Ile Cys Lys Phe Arg Lys Cys Glu Glu Leu Lys Lys
             165                 170                 175

 aaa cct ggc act tca cta gag aga aca cct gtt ccc agc gct gaa gca     1173
 Lys Pro Gly Thr Ser Leu Glu Arg Thr Pro Val Pro Ser Ala Glu Ala
         180                 185                 190

 ttc cga tgg ttc ttt taa agcagt agtatatctt attttcaagg catttggaaa     1227
 Phe Arg Trp Phe Phe 
     195

 tgaagggcaa actaatgtct tgttttaaga aactgcttag tccaccactg aagaaaatat   1287

 ccagaaatta ttttcatttt acgtataggg ctttcttcaa aaaaaaaaa               1336




      <210> 176
      <211> 2395
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(1033)

      <400> 176
 cccagcacaa gggaccatcc aagtcaccag ctccaaccag tcccaaatcc cgtgcccagg     60

 ctggagctgg atggccaccc agaaccctct tctgaggccc tctaccaagg cactgaaata    120

 tgcagcatat ccagttgaca gtatccttgg ctgggggaga gataagtctt acaaggagga    180

 gataagggcg tcctcggccg cccccaccgc ctcccag atg tac tat gcg gtt tcc     235
                                          Met Tyr Tyr Ala Val Ser
                                            1               5

 cag gcg cgc gtg aac gcg gtc ccc ggg acc atg ctg cgg cca cag cgg      283
 Gln Ala Arg Val Asn Ala Val Pro Gly Thr Met Leu Arg Pro Gln Arg
              10                  15                  20

 ccc gga gac ttg cag ctc ggg gcc tcc ctc tac gag ctg gtg ggc tac      331
 Pro Gly Asp Leu Gln Leu Gly Ala Ser Leu Tyr Glu Leu Val Gly Tyr
          25                  30                  35

 agg cag ccg ccc tcc tcc tcc tcc tcc tcc acc tcc tcc acc tcc tcc      379
 Arg Gln Pro Pro Ser Ser Ser Ser Ser Ser Thr Ser Ser Thr Ser Ser
      40                  45                  50

 act tcc tcc tcc tcc acg acg gcc ccc ctc ctc ccc aag gct gcg cgc      427
 Thr Ser Ser Ser Ser Thr Thr Ala Pro Leu Leu Pro Lys Ala Ala Arg
  55                  60                  65                  70

 gag aag ccg gag gcg ccg gcc gag cct cca ggc ccc ggg ccc ggg tca      475
 Glu Lys Pro Glu Ala Pro Ala Glu Pro Pro Gly Pro Gly Pro Gly Ser
                  75                  80                  85

 ggc gcg cac ccg ggc ggc agc gcc cgg ccg gac gcc aag gag gag cag      523
 Gly Ala His Pro Gly Gly Ser Ala Arg Pro Asp Ala Lys Glu Glu Gln
              90                  95                 100

 cag cag cag ctg cgg cgc aag atc aac agc cgc gag cgg aag cgc atg      571
 Gln Gln Gln Leu Arg Arg Lys Ile Asn Ser Arg Glu Arg Lys Arg Met
         105                 110                 115

 cag gac ctg aac ctg gcc atg gac gcc ctg cgc gag gtc atc ctg ccc      619
 Gln Asp Leu Asn Leu Ala Met Asp Ala Leu Arg Glu Val Ile Leu Pro
     120                 125                 130

 tac tca gcg gcg cac tgc cag ggc gcg ccc ggc cgc aag ctc tcc aag      667
 Tyr Ser Ala Ala His Cys Gln Gly Ala Pro Gly Arg Lys Leu Ser Lys
 135                 140                 145                 150

 ata gcc acg ctg ctg ctc gcc cgc aac tac atc cta ctg ctg ggc agc      715
 Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu Leu Leu Gly Ser
                 155                 160                 165

 tcg ctg cag gag ctg cgc cgc gcg ctg ggc gag ggc gcc ggg ccc gcc      763
 Ser Leu Gln Glu Leu Arg Arg Ala Leu Gly Glu Gly Ala Gly Pro Ala
             170                 175                 180

 gcg ccg cgc ctg ctg ctg gcc ggg ctg ccc ctg ctc gcc gcc gcg ccc      811
 Ala Pro Arg Leu Leu Leu Ala Gly Leu Pro Leu Leu Ala Ala Ala Pro
         185                 190                 195

 ggc tcc gtg ctg ctg gcg ccc ggc gcc gta gga ccc ccc gac gcg ctg      859
 Gly Ser Val Leu Leu Ala Pro Gly Ala Val Gly Pro Pro Asp Ala Leu
     200                 205                 210

 cgc ccc gcc aag tac ctg tcg ctg gcg ctg gac gag ccg ccg tgc ggc      907
 Arg Pro Ala Lys Tyr Leu Ser Leu Ala Leu Asp Glu Pro Pro Cys Gly
 215                 220                 225                 230

 cag ttc gct ctc ccc ggc ggc ggc gca ggc ggc ccc ggc ctc tgc acc      955
 Gln Phe Ala Leu Pro Gly Gly Gly Ala Gly Gly Pro Gly Leu Cys Thr
                 235                 240                 245

 tgc gcc gtg tgc aag ttc ccg cac ctg gtc ccg gcc agc ctg ggc ctg     1003
 Cys Ala Val Cys Lys Phe Pro His Leu Val Pro Ala Ser Leu Gly Leu
             250                 255                 260

 gcc gcc gtg cag gcg caa ttc tcc aag tga g ggcgggcctg ggctggggcg     1054
 Ala Ala Val Gln Ala Gln Phe Ser Lys 
         265                 270

 cgacctcggc ccggcctccc ttcgctcagc ttctccgcgc ccctgctccc tgcgtctggg   1114

 agagcgaggc cgagcaagga aagcatttcg aaccttccag tccagaggaa gggactgtcg   1174

 ggcaccccct tccccgcccc cacccctggg acgttaaagt gaccagagcg gatgttcgat   1234

 ggcgcctcgg ggcagtttgg ggttctgggt cggttccagc ggctttaggc agaaagtgct   1294

 cgctctcacc cagcacatct ctctccttgt ccctggagtt gcgcgcttcg cggggccgat   1354

 gtagaactta gggcgccttg ccgtggttgg cgcgccccgg gtgcagcgag aggccatccc   1414

 cgagcgctac ctccccggag cggagcacgc cggctcccag tactaggggc tgcgctcgag   1474

 cagtggcggg ggcggagggg tggttctttt ccttctcctc cgccagaggc cacgggcgcc   1534

 cttgttcccg ccggccaggt cctatcaaag gaggctgccg gaactcaaga ggcagaaaaa   1594

 gaccagttag gcggtgcaga cggtctggga cgtggcagac ggacggaccc tcggcggaca   1654

 ggtggtcggc gtcggggtgc ggggggtagg ggcaaggaca acgcagggtg cgctgggttg   1714

 ggacgtgggt ccacttttgt agaccagctg tttggagagc tgtatttaag actcgcgtat   1774

 ccagtgtttt gtcgcagaga gttttcgctc ttaaatcctg ggggtttctt agaaagcaac   1834

 ttagaactcg agattcacct ttcgtttccc tttccccaaa agtagcgtaa ccaacattta   1894

 agcttgctta aaaacgaaaa ccaaccgcct tgcatccagt gttcccgatt tactaaaata   1954

 ggtaaccagg cgtctcacag tcgccgtcct gtcaagagcg ctaatgaacg ttctcattaa   2014

 cacgcaggag taccgggagc cctgaaccgc ccgctgctcg gcggatccca gctgcggtgg   2074

 cgacggcggg aaggcgcttt ccgctgttcc tcagcgggcc gggcccttga ccagcgcggc   2134

 ccgcaggtct tccttctcgc cgtcttgcag ttgaagagct acatacgtag tcagtttcga   2194

 tttgttacag acgttaacaa attcctttac ccaaggttat gctatgacct ttccgcagtt   2254

 tactttgatt ttctatgttt aaggttttgg ttgttggtag tagccgaatt taactggcac   2314

 tttattttac ttctaacctt gtttcctgac ggtgtacaga atcaacaaaa taaaacattt   2374

 aaagtctgaa aaaaaaaaaa a                                             2395




      <210> 177
      <211> 5238
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(4700)

      <400> 177
 atcgatatgc attcgctagg cggggaatta aggagagtgc ctactgagga ccctcccagt     60

 gcagaagcat cacagaccca ggg    atg cag aaa ata ggg ccc gag aaa gac     110
                              Met Gln Lys Ile Gly Pro Glu Lys Asp
                                1               5

 agt gag gtg cag acc tca gtg atg agt ctg gga ctg aca gac gtg tcc      158
 Ser Glu Val Gln Thr Ser Val Met Ser Leu Gly Leu Thr Asp Val Ser
  10                  15                  20                  25

 aca ggg aag agg caa ttg aga ctt gga ttg aag ccc ttt aaa ccc cca      206
 Thr Gly Lys Arg Gln Leu Arg Leu Gly Leu Lys Pro Phe Lys Pro Pro
                  30                  35                  40

 ccc cca ccc ctg ctg aga ttc tgc tcc caa ggt gat agg aga aaa cac      254
 Pro Pro Pro Leu Leu Arg Phe Cys Ser Gln Gly Asp Arg Arg Lys His
              45                  50                  55

 cag aga gat gag gtc tca gag tca gag aca tca gtc aca gaa aga aag      302
 Gln Arg Asp Glu Val Ser Glu Ser Glu Thr Ser Val Thr Glu Arg Lys
          60                  65                  70

 atg gaa agt cag agg gca gtg ggg gtc tgg ggg gct gga ggc acc act      350
 Met Glu Ser Gln Arg Ala Val Gly Val Trp Gly Ala Gly Gly Thr Thr
      75                  80                  85

 tac ctc agt cac tgg ccc tgt ctt tgt gcc cca ggt ccg aag ccc cag      398
 Tyr Leu Ser His Trp Pro Cys Leu Cys Ala Pro Gly Pro Lys Pro Gln
  90                  95                 100                 105

 aag gac tct gtc tca gac tgg gcc att gtg ttg atc act ctc act ttg      446
 Lys Asp Ser Val Ser Asp Trp Ala Ile Val Leu Ile Thr Leu Thr Leu
                 110                 115                 120

 gtg gca gca att gtc agc cta atg tac ggt atc aag aag gcc tgc cag      494
 Val Ala Ala Ile Val Ser Leu Met Tyr Gly Ile Lys Lys Ala Cys Gln
             125                 130                 135

 ttc cgg agg gag atg agt ctg ggg tgt ggc tgt ggc tct gtg acc cct      542
 Phe Arg Arg Glu Met Ser Leu Gly Cys Gly Cys Gly Ser Val Thr Pro
         140                 145                 150

 tac agc agc cac cat gag ggg gag gct gcc agc cag cgc tac tct tgt      590
 Tyr Ser Ser His His Glu Gly Glu Ala Ala Ser Gln Arg Tyr Ser Cys
     155                 160                 165

 caa atg aaa ggt gct act aca ttc caa gaa tat cag aaa act ggg gaa      638
 Gln Met Lys Gly Ala Thr Thr Phe Gln Glu Tyr Gln Lys Thr Gly Glu
 170                 175                 180                 185

 ctc tca aca tcc gat cac ata ttt ccc ctc act cca ggc ctt gtt tat      686
 Leu Ser Thr Ser Asp His Ile Phe Pro Leu Thr Pro Gly Leu Val Tyr
                 190                 195                 200

 agt atc cct ttt gat cac att gtt ctg cat tca gga caa aga cct cca      734
 Ser Ile Pro Phe Asp His Ile Val Leu His Ser Gly Gln Arg Pro Pro
             205                 210                 215

 gag ctc cct aaa tct aca gaa atc cat gag caa aaa cgc cac tgc aac      782
 Glu Leu Pro Lys Ser Thr Glu Ile His Glu Gln Lys Arg His Cys Asn
         220                 225                 230

 acc aca cgc cat tct aag cca act gac aag cct aca ggc aac tcc aaa      830
 Thr Thr Arg His Ser Lys Pro Thr Asp Lys Pro Thr Gly Asn Ser Lys
     235                 240                 245

 act ata gac cac aaa agc tct aca gat aat cat gag gct cct ccc act      878
 Thr Ile Asp His Lys Ser Ser Thr Asp Asn His Glu Ala Pro Pro Thr
 250                 255                 260                 265

 tct gaa gaa aac tcc agc aac caa ggg aaa gac cca atg atc cgg aac      926
 Ser Glu Glu Asn Ser Ser Asn Gln Gly Lys Asp Pro Met Ile Arg Asn
                 270                 275                 280

 cag cgc tct gtt gat cct gct gac tcc act acc aca cat aaa gaa tcc      974
 Gln Arg Ser Val Asp Pro Ala Asp Ser Thr Thr Thr His Lys Glu Ser
             285                 290                 295

 gct gga aaa aaa cat ata acg cca gca ccc aag agc aaa ata aac tgt     1022
 Ala Gly Lys Lys His Ile Thr Pro Ala Pro Lys Ser Lys Ile Asn Cys
         300                 305                 310

 cgt aag tcc aca aca ggc aaa tca acg gta aca aga aaa tca gat aaa     1070
 Arg Lys Ser Thr Thr Gly Lys Ser Thr Val Thr Arg Lys Ser Asp Lys
     315                 320                 325

 act gga aga cct ttg gaa aag tcc atg agt act ttg gat aag aca agt     1118
 Thr Gly Arg Pro Leu Glu Lys Ser Met Ser Thr Leu Asp Lys Thr Ser
 330                 335                 340                 345

 acc agc tca cat aag act aca act tcc ttc cac aac tca ggc aat tca     1166
 Thr Ser Ser His Lys Thr Thr Thr Ser Phe His Asn Ser Gly Asn Ser
                 350                 355                 360

 cag acc aag caa aaa agc aca tct ttt cca gaa aaa atc aca gca gcc     1214
 Gln Thr Lys Gln Lys Ser Thr Ser Phe Pro Glu Lys Ile Thr Ala Ala
             365                 370                 375

 tca aaa aca aca tac aag acc aca gga acc cca gaa gag tca gaa aaa     1262
 Ser Lys Thr Thr Tyr Lys Thr Thr Gly Thr Pro Glu Glu Ser Glu Lys
         380                 385                 390

 act gaa gat tcc aga aca aca gtt gcc tca gac aag ctc ctg aca aaa     1310
 Thr Glu Asp Ser Arg Thr Thr Val Ala Ser Asp Lys Leu Leu Thr Lys
     395                 400                 405

 act aca aaa aac ata caa gag acc ata tca gcc aat gag ctc aca caa     1358
 Thr Thr Lys Asn Ile Gln Glu Thr Ile Ser Ala Asn Glu Leu Thr Gln
 410                 415                 420                 425

 tct cta gca gag cct aca gaa cat gga gga agg aca gcc aat gag aac     1406
 Ser Leu Ala Glu Pro Thr Glu His Gly Gly Arg Thr Ala Asn Glu Asn
                 430                 435                 440

 aac aca cca tcc cca gca gag cct aca gaa aat aga gaa agg aca gcc     1454
 Asn Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala
             445                 450                 455

 aat gag aac acc aca cta tcc cca gca gag cct aca gaa aat aga gaa     1502
 Asn Glu Asn Thr Thr Leu Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu
         460                 465                 470

 agg aca gcc aat gag aac acc gca cca ttc cca gca ggg cct aca gaa     1550
 Arg Thr Ala Asn Glu Asn Thr Ala Pro Phe Pro Ala Gly Pro Thr Glu
     475                 480                 485

 aat aga gaa atg aca gcc aat gag aat acc aca cta ttc cca gca gag     1598
 Asn Arg Glu Met Thr Ala Asn Glu Asn Thr Thr Leu Phe Pro Ala Glu
 490                 495                 500                 505

 cct aca gaa cat gga gaa agg aca gcc aat gag aac acc aca cca tcc     1646
 Pro Thr Glu His Gly Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser
                 510                 515                 520

 cca gca gag cct aca gaa cat gga gaa agg aca gcc aat gag aac act     1694
 Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr Ala Asn Glu Asn Thr
             525                 530                 535

 aca cca tcc cca gca gag cct aca gaa cat gga gaa agg acc cca ttt     1742
 Thr Pro Ser Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Phe
         540                 545                 550

 gcc aat gac aaa acc aca tca tcc tca gca gag tct aca gaa cat gga     1790
 Ala Asn Asp Lys Thr Thr Ser Ser Ser Ala Glu Ser Thr Glu His Gly
     555                 560                 565

 gaa agg acc cca ctg gcc aac gag aac acc aca cca tcc cca gca gag     1838
 Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu
 570                 575                 580                 585

 cct aca gaa aat aga gaa agg aca gcc aat gag aac acc aca cca tcc     1886
 Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser
                 590                 595                 600

 cca gca ggg cct aca gaa aac aga gaa acg aca gcc aac gag aag acc     1934
 Pro Ala Gly Pro Thr Glu Asn Arg Glu Thr Thr Ala Asn Glu Lys Thr
             605                 610                 615

 aca cta tcc cca gta gag cct aca gaa aat aga gaa aca aca gcc aat     1982
 Thr Leu Ser Pro Val Glu Pro Thr Glu Asn Arg Glu Thr Thr Ala Asn
         620                 625                 630

 gag aag acc aca cca tcc cca gca gag cct aca gaa aat gga caa agg     2030
 Glu Lys Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Gly Gln Arg
     635                 640                 645

 acc cca ttt gcc aat gag aaa acc aca tca tcc tca gca gag cct aca     2078
 Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr
 650                 655                 660                 665

 gaa cac gga gaa agg acc cca ctg gcc aat gag aac acc aca cca tcc     2126
 Glu His Gly Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Pro Ser
                 670                 675                 680

 cca gca gag cct aca gaa aat aga gaa agg aca gcc aat gag aag acc     2174
 Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr
             685                 690                 695

 aca cca tcc cca gca gag cct aca gaa aat gga gac agg act cct ttg     2222
 Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Gly Asp Arg Thr Pro Leu
         700                 705                 710

 gcc aat gag aag acc acg cca tct cta gca gag cct aca gaa aat gga     2270
 Ala Asn Glu Lys Thr Thr Pro Ser Leu Ala Glu Pro Thr Glu Asn Gly
     715                 720                 725

 caa agg acc cca ttt gcc aat gag aag acc aca tca tcc tca gca gag     2318
 Gln Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu
 730                 735                 740                 745

 cct aca gaa cac gaa gaa agg act cca ctg gcc aat gag aac acc aca     2366
 Pro Thr Glu His Glu Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr
                 750                 755                 760

 cca tcc ccg gca gag cct aca gaa aat aga gaa agg aca gcc aat gag     2414
 Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu
             765                 770                 775

 aac acc aca cca tcc cca gca ggg cct aca gaa aat aga gaa atg aca     2462
 Asn Thr Thr Pro Ser Pro Ala Gly Pro Thr Glu Asn Arg Glu Met Thr
         780                 785                 790

 gcc aac gag aag acc aca cta ttc cca gca gag cct aca gaa aat aga     2510
 Ala Asn Glu Lys Thr Thr Leu Phe Pro Ala Glu Pro Thr Glu Asn Arg
     795                 800                 805

 gaa agg aca gcc aat gag aag acc aca tca tcc cca gca gag cct aca     2558
 Glu Arg Thr Ala Asn Glu Lys Thr Thr Ser Ser Pro Ala Glu Pro Thr
 810                 815                 820                 825

 gaa aat gga caa agg acc cca ttt gcc aat gag aaa acc aca tca tcc     2606
 Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser
                 830                 835                 840

 tca gca gag cct aca gaa cac gga gaa agg acc cca ctg gcc aat gag     2654
 Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn Glu
             845                 850                 855

 aac acc aca cta tcc cca gca gag cct aca gaa aat aga gaa agg aca     2702
 Asn Thr Thr Leu Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr
         860                 865                 870

 gcc aat gag aag acc aca cca ttc cca gca gag cct aca gaa aat aga     2750
 Ala Asn Glu Lys Thr Thr Pro Phe Pro Ala Glu Pro Thr Glu Asn Arg
     875                 880                 885

 gaa agg aca gcc aat gag aac acc aca cca tcc cca gca cag cct aca     2798
 Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Gln Pro Thr
 890                 895                 900                 905

 gaa aat gga gac agg act cca ttg gcc aat gag aag acc aca cca tct     2846
 Glu Asn Gly Asp Arg Thr Pro Leu Ala Asn Glu Lys Thr Thr Pro Ser
                 910                 915                 920

 cta gca gag cct aca gaa aat gga aaa agg acc cca ttt gcc aat gag     2894
 Leu Ala Glu Pro Thr Glu Asn Gly Lys Arg Thr Pro Phe Ala Asn Glu
             925                 930                 935

 aag acc aca tca tcc tca gca gag cct aca gaa cac gca gaa agg act     2942
 Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Ala Glu Arg Thr
         940                 945                 950

 cca ctg gcc aat gag aac acc aca tca tcc cca gca gag cct aca gaa     2990
 Pro Leu Ala Asn Glu Asn Thr Thr Ser Ser Pro Ala Glu Pro Thr Glu
     955                 960                 965

 aat aga gaa agg aca gcc aat gag aag acc aca caa ttc cca gca gag     3038
 Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr Thr Gln Phe Pro Ala Glu
 970                 975                 980                 985

 cct aca gaa aat aga gaa agc aca gcc aat gag aag acc aca cca ttc     3086
 Pro Thr Glu Asn Arg Glu Ser Thr Ala Asn Glu Lys Thr Thr Pro Phe
                 990                 995                1000

 cca gca gag cct aca gaa aat aga gaa tgg aca gcc aat gag aac acc     3134
 Pro Ala Glu Pro Thr Glu Asn Arg Glu Trp Thr Ala Asn Glu Asn Thr
            1005                1010                1015

 aca cta tcc cca gca gag cct aca gaa cat gaa gaa atg acc cca ttg     3182
 Thr Leu Ser Pro Ala Glu Pro Thr Glu His Glu Glu Met Thr Pro Leu
        1020                1025                1030

 gcc aat gag aag acc aca cta tcc cca gca gag cct aca gaa aat gga     3230
 Ala Asn Glu Lys Thr Thr Leu Ser Pro Ala Glu Pro Thr Glu Asn Gly
    1035                1040                1045

 gaa agg acc cca ttt acc aat gag aag acc aca cca tcc tca gca gag     3278
 Glu Arg Thr Pro Phe Thr Asn Glu Lys Thr Thr Pro Ser Ser Ala Glu
1050                1055                1060                1065

 cct aca gaa cat gga gaa agg acc cca ctg gcc aat gag atc acc aca     3326
 Pro Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn Glu Ile Thr Thr
                1070                1075                1080

 cca tcc cga gca gag cct aca gaa cat gga gaa agg ata gcc aat gag     3374
 Pro Ser Arg Ala Glu Pro Thr Glu His Gly Glu Arg Ile Ala Asn Glu
            1085                1090                1095

 aag gcc aca cca tcc cca gca aag cct aca gaa cat gga gaa acg aca     3422
 Lys Ala Thr Pro Ser Pro Ala Lys Pro Thr Glu His Gly Glu Thr Thr
        1100                1105                1110

 gtc aat gag gac acc aca cca tcc tca gca gag cct aca gaa aat gga     3470
 Val Asn Glu Asp Thr Thr Pro Ser Ser Ala Glu Pro Thr Glu Asn Gly
    1115                1120                1125

 gaa agg acc cca ctg gcc aat gag aac acc aca aca tcc cca aca gag     3518
 Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Thr Ser Pro Thr Glu
1130                1135                1140                1145

 tct aca gaa cat gga gaa agg aca gcc aat gag aag acc aca cca tcc     3566
 Ser Thr Glu His Gly Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro Ser
                1150                1155                1160

 cca gca gag cct aca gaa cat gga gaa agg aca cca tca gcc aat gag     3614
 Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Ser Ala Asn Glu
            1165                1170                1175

 aag acc ata cca tct cca gca aag cct aca gaa cac gaa gaa atg acc     3662
 Lys Thr Ile Pro Ser Pro Ala Lys Pro Thr Glu His Glu Glu Met Thr
        1180                1185                1190

 cca tcg gcc aat gag aac acc aca cca tcc cca gta aag cct aca gaa     3710
 Pro Ser Ala Asn Glu Asn Thr Thr Pro Ser Pro Val Lys Pro Thr Glu
    1195                1200                1205

 cat gga gaa aag act aca ttg gcc aat gag aag atc aca cta tcc cca     3758
 His Gly Glu Lys Thr Thr Leu Ala Asn Glu Lys Ile Thr Leu Ser Pro
1210                1215                1220                1225

 gaa ggg cct aca gaa cat gga gca aaa act acg tcg gcc aat gag aag     3806
 Glu Gly Pro Thr Glu His Gly Ala Lys Thr Thr Ser Ala Asn Glu Lys
                1230                1235                1240

 atc aca cca tcc cta gca aag cct aca gaa cat gga gaa agg acc aca     3854
 Ile Thr Pro Ser Leu Ala Lys Pro Thr Glu His Gly Glu Arg Thr Thr
            1245                1250                1255

 tca ccc aat gac aag atc acc tca tct gca gca gag tct aca gaa cat     3902
 Ser Pro Asn Asp Lys Ile Thr Ser Ser Ala Ala Glu Ser Thr Glu His
        1260                1265                1270

 aga gat agg gct aca tca gcc aat gtg atc aca cca gcc cca gca gag     3950
 Arg Asp Arg Ala Thr Ser Ala Asn Val Ile Thr Pro Ala Pro Ala Glu
    1275                1280                1285

 cct ata aaa cat gca aaa agg acc aca ttg gcc cat gag aag atg aca     3998
 Pro Ile Lys His Ala Lys Arg Thr Thr Leu Ala His Glu Lys Met Thr
1290                1295                1300                1305

 caa gtc aca gaa aag tcc aca gaa cac cca gaa aag acc acg tca acc     4046
 Gln Val Thr Glu Lys Ser Thr Glu His Pro Glu Lys Thr Thr Ser Thr
                1310                1315                1320

 aca gag aaa acc aca aga acc cca gaa aag cct acg cta tac tca gag     4094
 Thr Glu Lys Thr Thr Arg Thr Pro Glu Lys Pro Thr Leu Tyr Ser Glu
            1325                1330                1335

 aag acc ata tgc acc aaa ggg aaa aac aca cca gtc cca gaa aag cct     4142
 Lys Thr Ile Cys Thr Lys Gly Lys Asn Thr Pro Val Pro Glu Lys Pro
        1340                1345                1350

 aca gaa aac ctg ggg aac acc aca ctg acc act gag acc ata aaa gcc     4190
 Thr Glu Asn Leu Gly Asn Thr Thr Leu Thr Thr Glu Thr Ile Lys Ala
    1355                1360                1365

 cca gta aag tcc aca gaa aac cca gaa aaa aca gca gca gtc aca aag     4238
 Pro Val Lys Ser Thr Glu Asn Pro Glu Lys Thr Ala Ala Val Thr Lys
1370                1375                1380                1385

 act ata aaa cct tca gtc aag gtc aca gga gac aaa tct ctc act act     4286
 Thr Ile Lys Pro Ser Val Lys Val Thr Gly Asp Lys Ser Leu Thr Thr
                1390                1395                1400

 acc tct tct cat cta aat aaa act gaa gtt act cat cag gtg ccc act     4334
 Thr Ser Ser His Leu Asn Lys Thr Glu Val Thr His Gln Val Pro Thr
            1405                1410                1415

 ggt tct ttc acc ctc att aca tct aga acg aag ctg agt tct atc aca     4382
 Gly Ser Phe Thr Leu Ile Thr Ser Arg Thr Lys Leu Ser Ser Ile Thr
        1420                1425                1430

 tca gaa gcc aca gga aac gag agc cat cca tac ctc aat aaa gat ggc     4430
 Ser Glu Ala Thr Gly Asn Glu Ser His Pro Tyr Leu Asn Lys Asp Gly
    1435                1440                1445

 tca cag aaa ggt atc cac gct gga cag atg gga gag aat gat tca ttc     4478
 Ser Gln Lys Gly Ile His Ala Gly Gln Met Gly Glu Asn Asp Ser Phe
1450                1455                1460                1465

 cct gca tgg gcc ata gtt att gtg gtc ctg gtg gct gtg att ctc ctc     4526
 Pro Ala Trp Ala Ile Val Ile Val Val Leu Val Ala Val Ile Leu Leu
                1470                1475                1480

 ctg gtg ttc ctt ggc ctg atc ttc ttg gtc tcc tat atg atg cgg aca     4574
 Leu Val Phe Leu Gly Leu Ile Phe Leu Val Ser Tyr Met Met Arg Thr
            1485                1490                1495

 cgc cgc aca cta acc cag aac acc cag tac aat gat gca gag gat gag     4622
 Arg Arg Thr Leu Thr Gln Asn Thr Gln Tyr Asn Asp Ala Glu Asp Glu
        1500                1505                1510

 ggt ggc ccc aat tcc tac ccg gtc tac ctg atg gag cag cag aat ctt     4670
 Gly Gly Pro Asn Ser Tyr Pro Val Tyr Leu Met Glu Gln Gln Asn Leu
    1515                1520                1525

 ggc atg ggc cag atc cct tcc cca cgg tga t cttggagtag gcgcccagcc     4721
 Gly Met Gly Gln Ile Pro Ser Pro Arg 
1530                1535

 ctggctcttc catgctctgc ccctttcctg gatgaggaac cagactcaca atttctattt   4781

 ccgggactac aggaagggca gagaatactg acggttacca gtattaaccc ttcatctgtt   4841

 cttgaaactg gttggggaat gaggtgataa gcaaggaggg tgtaagttta ggggacaaag   4901

 aagaaagaat gaataatacg agcagacatt ctctgtagaa ggtaatggtc tgagaatgaa   4961

 aaggtgtttg atggacatgt tgtgggggca ccaatgcaga atactgcact gagtcctaaa   5021

 ggaaggacag gagccttata ggcaatgccc cagactgact tgtgagtggg gtttatgggg   5081

 aaagggaggg actgagggca gagtctctgg gtttcaggac agcattatgt tatttccatt   5141

 cactattact taagagtttg tgtgtaaaca ggctcatctc tgagttctca ggacccttgc   5201

 ccccaccccc atttttttaa tgaaaaaaaa aaaaaaa                            5238




      <210> 178
      <211> 1117
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(1067)

      <400> 178
 taggggcggg ccggctggcg tcccctttcc ggccggtccc c    atg gag gcg ctg      53
                                                  Met Glu Ala Leu
                                                    1

 ggg aag ctg aag cag ttc gat gcc tac ccc aag act ttg gag gac ttc      101
 Gly Lys Leu Lys Gln Phe Asp Ala Tyr Pro Lys Thr Leu Glu Asp Phe
   5                  10                  15                  20

 cgg gtc aag acc tgc ggg ggc gcc acc gtg acc att gtc agt ggc ctt      149
 Arg Val Lys Thr Cys Gly Gly Ala Thr Val Thr Ile Val Ser Gly Leu
                  25                  30                  35

 ctc atg ctg cta ctg ttc ctg tcc gag ctg cag tat tac ctc acc acg      197
 Leu Met Leu Leu Leu Phe Leu Ser Glu Leu Gln Tyr Tyr Leu Thr Thr
              40                  45                  50

 gag gtg cat cct gag ctc tac gtg gac aag tcg cgg gga gat aaa ctg      245
 Glu Val His Pro Glu Leu Tyr Val Asp Lys Ser Arg Gly Asp Lys Leu
          55                  60                  65

 aag atc aac atc gat gta ctt ttt ccg cac atg cct tgt gcc tat ctg      293
 Lys Ile Asn Ile Asp Val Leu Phe Pro His Met Pro Cys Ala Tyr Leu
      70                  75                  80

 agt att gat gcc atg gat gtg gcc gga gaa cag cag ctg gat gtg gaa      341
 Ser Ile Asp Ala Met Asp Val Ala Gly Glu Gln Gln Leu Asp Val Glu
  85                  90                  95                 100

 cac aac ctg ttc aag caa cga cta gat aaa gat ggc atc ccc gtg agc      389
 His Asn Leu Phe Lys Gln Arg Leu Asp Lys Asp Gly Ile Pro Val Ser
                 105                 110                 115

 tca gag gct gag cgg cat gag ctt ggg aaa gtc gag gtg acg gtg ttt      437
 Ser Glu Ala Glu Arg His Glu Leu Gly Lys Val Glu Val Thr Val Phe
             120                 125                 130

 gac cct gac tcc ctg gac cct gat cgc tgt gag agc tgc tat ggt gct      485
 Asp Pro Asp Ser Leu Asp Pro Asp Arg Cys Glu Ser Cys Tyr Gly Ala
         135                 140                 145

 gag gca gaa gat atc aag tgc tgt aac acc tgt gaa gat gtg cgg gag      533
 Glu Ala Glu Asp Ile Lys Cys Cys Asn Thr Cys Glu Asp Val Arg Glu
     150                 155                 160

 gca tat cgc cgt aga ggc tgg gcc ttc aag aac cca gat act att gag      581
 Ala Tyr Arg Arg Arg Gly Trp Ala Phe Lys Asn Pro Asp Thr Ile Glu
 165                 170                 175                 180

 cag tgc cgg cga gag ggc ttc agc cag aag atg cag gag cag aag aat      629
 Gln Cys Arg Arg Glu Gly Phe Ser Gln Lys Met Gln Glu Gln Lys Asn
                 185                 190                 195

 gaa ggc tgc cag gtg tat ggc ttc ttg gaa gtc aat aag gtg gcc gga      677
 Glu Gly Cys Gln Val Tyr Gly Phe Leu Glu Val Asn Lys Val Ala Gly
             200                 205                 210

 aac ttc cac ttt gcc cct ggg aag agc ttc cag cag tcc cat gtg cac      725
 Asn Phe His Phe Ala Pro Gly Lys Ser Phe Gln Gln Ser His Val His
         215                 220                 225

 gtc cat gac ttg cag agc ttt ggc ctt gac aac atc aac atg acc cac      773
 Val His Asp Leu Gln Ser Phe Gly Leu Asp Asn Ile Asn Met Thr His
     230                 235                 240

 tac atc cag cac ctg tca ttt ggg gag gac tat cca ggc att gtg aac      821
 Tyr Ile Gln His Leu Ser Phe Gly Glu Asp Tyr Pro Gly Ile Val Asn
 245                 250                 255                 260

 ccc ctg gac cac acc aat gtc act gcg ccc caa gcc tcc atg atg ttc      869
 Pro Leu Asp His Thr Asn Val Thr Ala Pro Gln Ala Ser Met Met Phe
                 265                 270                 275

 cag tac ttt gtg aag gtg gtg ccc act gtg tac atg aag gtg aag ctg      917
 Gln Tyr Phe Val Lys Val Val Pro Thr Val Tyr Met Lys Val Lys Leu
             280                 285                 290

 acg gag aag cac agg tcc ttc acc cac ttc ctg aca ggt gtg tgc gcc      965
 Thr Glu Lys His Arg Ser Phe Thr His Phe Leu Thr Gly Val Cys Ala
         295                 300                 305

 atc att ggg ggc atg ttc aca gtg gct gga ctc atc gat tcg ctc atc     1013
 Ile Ile Gly Gly Met Phe Thr Val Ala Gly Leu Ile Asp Ser Leu Ile
     310                 315                 320

 tac cac tca gca cga gcc atc cag aag aaa att gat cta ggg aag aca     1061
 Tyr His Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp Leu Gly Lys Thr
 325                 330                 335                 340

 acg tag tcaccctcgg tgcttcctct gtctcctctt tctccctggc ctgtggttgt      1117
 Thr 






      <210> 179
      <211> 2848
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(2794)

      <400> 179
 ctgaagtttc agtgtagtca gagagctctt caagtaataa atc  atg gag acc agt      55
                                                  Met Glu Thr Ser
                                                    1

 cag gaa act tcc ctc ttc ttg gtg aag atc ttg gag gaa ctg gac agc      103
 Gln Glu Thr Ser Leu Phe Leu Val Lys Ile Leu Glu Glu Leu Asp Ser
   5                  10                  15                  20

 aag caa aat acc gtt tct tat cag gac ctg tgc aaa tct ctc tgt gcc      151
 Lys Gln Asn Thr Val Ser Tyr Gln Asp Leu Cys Lys Ser Leu Cys Ala
                  25                  30                  35

 cgg ttc gac ctg tcg cag ctt gcc aaa ctg aga agt gtg ctc ttc tac      199
 Arg Phe Asp Leu Ser Gln Leu Ala Lys Leu Arg Ser Val Leu Phe Tyr
              40                  45                  50

 aca gct tgt ctc gat ccc aat ttt cca gcc acg cta ttc aaa gac aag      247
 Thr Ala Cys Leu Asp Pro Asn Phe Pro Ala Thr Leu Phe Lys Asp Lys
          55                  60                  65

 atg aaa tgc act gtg aat aac cag caa tca aag aaa atc atg gtg gca      295
 Met Lys Cys Thr Val Asn Asn Gln Gln Ser Lys Lys Ile Met Val Ala
      70                  75                  80

 gca gat att gtg acg ata ttc aac ctg atc caa atg aat ggc ggg gct      343
 Ala Asp Ile Val Thr Ile Phe Asn Leu Ile Gln Met Asn Gly Gly Ala
  85                  90                  95                 100

 gcc aag gag aag ctg ccc acg ggc cgc cag aag gta cgc aag aag gag      391
 Ala Lys Glu Lys Leu Pro Thr Gly Arg Gln Lys Val Arg Lys Lys Glu
                 105                 110                 115

 gca tcc ttt gaa tca tgt agg tcg gac aca gag atc tgc aat gca gct      439
 Ala Ser Phe Glu Ser Cys Arg Ser Asp Thr Glu Ile Cys Asn Ala Ala
             120                 125                 130

 gag tgt gag ccc ctg aac tgt gag ctg agt gag agg tct ttc agc cgg      487
 Glu Cys Glu Pro Leu Asn Cys Glu Leu Ser Glu Arg Ser Phe Ser Arg
         135                 140                 145

 ggc tac ccc atc agg cag tcg tcc aag tgc cgg aag atg gac tgc aag      535
 Gly Tyr Pro Ile Arg Gln Ser Ser Lys Cys Arg Lys Met Asp Cys Lys
     150                 155                 160

 gac tgc cca cag ttt gtc cct gcc tct gag cct aac ttc ctg ttg gga      583
 Asp Cys Pro Gln Phe Val Pro Ala Ser Glu Pro Asn Phe Leu Leu Gly
 165                 170                 175                 180

 gtt agc aaa gag gtg aaa aac cgc gcc gct tcc ctg gac agg ttg cag      631
 Val Ser Lys Glu Val Lys Asn Arg Ala Ala Ser Leu Asp Arg Leu Gln
                 185                 190                 195

 gcc ctg gct ccg tac tct gtg acc agc cct cag ccc tgt gag atg cag      679
 Ala Leu Ala Pro Tyr Ser Val Thr Ser Pro Gln Pro Cys Glu Met Gln
             200                 205                 210

 agg acc tac ttc ccc atg aac atc gaa aac gag tcc att tca gac cag      727
 Arg Thr Tyr Phe Pro Met Asn Ile Glu Asn Glu Ser Ile Ser Asp Gln
         215                 220                 225

 gac tcc ctg ccc atc aat cag agc atc aag gag acc ttc att tcc aat      775
 Asp Ser Leu Pro Ile Asn Gln Ser Ile Lys Glu Thr Phe Ile Ser Asn
     230                 235                 240

 gag gag cca ttt gtg gtc cag tcc tgt gtc cag aaa agg aat atc ttc      823
 Glu Glu Pro Phe Val Val Gln Ser Cys Val Gln Lys Arg Asn Ile Phe
 245                 250                 255                 260

 aaa gag gat ttt cac aat ttg atg gca gtg tcc ccc agt ttg gtt ggc      871
 Lys Glu Asp Phe His Asn Leu Met Ala Val Ser Pro Ser Leu Val Gly
                 265                 270                 275

 ccc atc agc aaa gca gag aat gag cac agg gaa ccc cag agt cga aag      919
 Pro Ile Ser Lys Ala Glu Asn Glu His Arg Glu Pro Gln Ser Arg Lys
             280                 285                 290

 gaa ccc cac aag cca ccc ttc ttc aac cac agc ttt gaa atg ccc tat      967
 Glu Pro His Lys Pro Pro Phe Phe Asn His Ser Phe Glu Met Pro Tyr
         295                 300                 305

 aac agc cag tac ctg aat cca gtg tat tcc ccg gtt cct gac aaa agg     1015
 Asn Ser Gln Tyr Leu Asn Pro Val Tyr Ser Pro Val Pro Asp Lys Arg
     310                 315                 320

 cga gca aag cac gaa agc tta gat gac ctt caa gcc tct aca tat ttt     1063
 Arg Ala Lys His Glu Ser Leu Asp Asp Leu Gln Ala Ser Thr Tyr Phe
 325                 330                 335                 340

 ggg ccc act ccc gtg atg gga acc caa gaa gcc agg cgc tgt cta ggg     1111
 Gly Pro Thr Pro Val Met Gly Thr Gln Glu Ala Arg Arg Cys Leu Gly
                 345                 350                 355

 aag ccc aac aag cag act ccc tgg cca gcc aaa agc tgg agc cta aac     1159
 Lys Pro Asn Lys Gln Thr Pro Trp Pro Ala Lys Ser Trp Ser Leu Asn
             360                 365                 370

 aca gag gaa gtt cct gac ttt gaa cgg tcc ttt ttc aat aga aat ccc     1207
 Thr Glu Glu Val Pro Asp Phe Glu Arg Ser Phe Phe Asn Arg Asn Pro
         375                 380                 385

 tcc gag gag aag cta cac tat cca aat gcc agt agc cag acc ccc aat     1255
 Ser Glu Glu Lys Leu His Tyr Pro Asn Ala Ser Ser Gln Thr Pro Asn
     390                 395                 400

 ttc cca gcc cca gaa agg cgc cca act tac ctt gtg cca aag gat caa     1303
 Phe Pro Ala Pro Glu Arg Arg Pro Thr Tyr Leu Val Pro Lys Asp Gln
 405                 410                 415                 420

 cag cca att ctc ccc att gct tat gcg gca aaa caa aat ggg ctc aaa     1351
 Gln Pro Ile Leu Pro Ile Ala Tyr Ala Ala Lys Gln Asn Gly Leu Lys
                 425                 430                 435

 tct aaa gag atc tca tcc cct gtt gac ctg gag aag cat gaa cca gtc     1399
 Ser Lys Glu Ile Ser Ser Pro Val Asp Leu Glu Lys His Glu Pro Val
             440                 445                 450

 aaa aag ttt aaa gac aag agc att aac tgc acc agt ggg cag ctc agc     1447
 Lys Lys Phe Lys Asp Lys Ser Ile Asn Cys Thr Ser Gly Gln Leu Ser
         455                 460                 465

 tca gac acc agt agc gtg ggc acc cag act gag cac gtg ctg gag ccc     1495
 Ser Asp Thr Ser Ser Val Gly Thr Gln Thr Glu His Val Leu Glu Pro
     470                 475                 480

 aag aaa tgc aga gac ctg tgc acc tct ggt cag ggc aag tac agt gac     1543
 Lys Lys Cys Arg Asp Leu Cys Thr Ser Gly Gln Gly Lys Tyr Ser Asp
 485                 490                 495                 500

 agg cac acc atg aag cac tca gac gat gac tca gaa att gtc agc gac     1591
 Arg His Thr Met Lys His Ser Asp Asp Asp Ser Glu Ile Val Ser Asp
                 505                 510                 515

 gac atc agt gac att ttc cga ttt ctt gat gac atg agc atc agt ggc     1639
 Asp Ile Ser Asp Ile Phe Arg Phe Leu Asp Asp Met Ser Ile Ser Gly
             520                 525                 530

 tcc acg gga gtg ata cag tcg tcc tgc tac aac agc aca gga tcc ttg     1687
 Ser Thr Gly Val Ile Gln Ser Ser Cys Tyr Asn Ser Thr Gly Ser Leu
         535                 540                 545

 tct cag ctc cat aag tca gac tgc gac agt tcc cct gag cac aac tta     1735
 Ser Gln Leu His Lys Ser Asp Cys Asp Ser Ser Pro Glu His Asn Leu
     550                 555                 560

 acc aaa att gcc aat ggg gtc ccc aac agc aag gga gac aag ggc aac     1783
 Thr Lys Ile Ala Asn Gly Val Pro Asn Ser Lys Gly Asp Lys Gly Asn
 565                 570                 575                 580

 cgg cct gaa aac acc cac cac tcg gaa gaa gag ctg aag acc agt gtg     1831
 Arg Pro Glu Asn Thr His His Ser Glu Glu Glu Leu Lys Thr Ser Val
                 585                 590                 595

 tgc aaa ctg gtg ctc agg att ggc gaa atc gaa cgg aag ctg gaa tcc     1879
 Cys Lys Leu Val Leu Arg Ile Gly Glu Ile Glu Arg Lys Leu Glu Ser
             600                 605                 610

 ctg tcg ggt gtc cgt gat gaa atc tcc cag gtc ttg ggc aaa cta aat     1927
 Leu Ser Gly Val Arg Asp Glu Ile Ser Gln Val Leu Gly Lys Leu Asn
         615                 620                 625

 aaa ttg gac cag aaa atg caa cag cct gag aag gtg agt gtg cag ata     1975
 Lys Leu Asp Gln Lys Met Gln Gln Pro Glu Lys Val Ser Val Gln Ile
     630                 635                 640

 gat ctg aac tcc ttg aca agc gag ggt ccg tct gat gac agt gcc tct     2023
 Asp Leu Asn Ser Leu Thr Ser Glu Gly Pro Ser Asp Asp Ser Ala Ser
 645                 650                 655                 660

 ccc cgg atg ttc cac gca cac agt ggc tcc cac gga ccc aaa cta gag     2071
 Pro Arg Met Phe His Ala His Ser Gly Ser His Gly Pro Lys Leu Glu
                 665                 670                 675

 aac aac cct gac tgg tgc tgc tct gat gct agc ggg agc aac agt gaa     2119
 Asn Asn Pro Asp Trp Cys Cys Ser Asp Ala Ser Gly Ser Asn Ser Glu
             680                 685                 690

 agc ctg cgg gtc aag gcc tta aaa aaa agc ctc ttc acc agg cca tcc     2167
 Ser Leu Arg Val Lys Ala Leu Lys Lys Ser Leu Phe Thr Arg Pro Ser
         695                 700                 705

 tct agg tcc cta aca gag gag aac agt gcc aca gag tcc aaa att gcc     2215
 Ser Arg Ser Leu Thr Glu Glu Asn Ser Ala Thr Glu Ser Lys Ile Ala
     710                 715                 720

 agc atc tcc aac tcg ccc aga gac tgg cgc acc atc act tat acc aac     2263
 Ser Ile Ser Asn Ser Pro Arg Asp Trp Arg Thr Ile Thr Tyr Thr Asn
 725                 730                 735                 740

 cgt gtg ggc ctc aat gag gag gag ata aaa gac aca ggc cca gga gat     2311
 Arg Val Gly Leu Asn Glu Glu Glu Ile Lys Asp Thr Gly Pro Gly Asp
                 745                 750                 755

 aat aaa gac tgg cat cgg aaa tct aaa gag gca gac agg cag tac gac     2359
 Asn Lys Asp Trp His Arg Lys Ser Lys Glu Ala Asp Arg Gln Tyr Asp
             760                 765                 770

 att ccc cca cag cac cga ctg ccc aag cag ccc aaa gat ggc ttc ctg     2407
 Ile Pro Pro Gln His Arg Leu Pro Lys Gln Pro Lys Asp Gly Phe Leu
         775                 780                 785

 gtg gag cag gtg ttc agc cct cac ccc tac cct gcc tcc ctc aag gcc     2455
 Val Glu Gln Val Phe Ser Pro His Pro Tyr Pro Ala Ser Leu Lys Ala
     790                 795                 800

 cac atg aag agc aac ccc ctg tac aca gac atg cgg ctg acc gag ttg     2503
 His Met Lys Ser Asn Pro Leu Tyr Thr Asp Met Arg Leu Thr Glu Leu
 805                 810                 815                 820

 gcc gag gtg aag cgg ggc caa cct tct tgg acc att gag gag tat gca     2551
 Ala Glu Val Lys Arg Gly Gln Pro Ser Trp Thr Ile Glu Glu Tyr Ala
                 825                 830                 835

 cgg aat gcg ggc gac aag ggc aag ctg aca gcc ctg gac ctg cag acg     2599
 Arg Asn Ala Gly Asp Lys Gly Lys Leu Thr Ala Leu Asp Leu Gln Thr
             840                 845                 850

 caa gaa tct tta aac cca aat aat tta gag tac tgg atg gaa gac att     2647
 Gln Glu Ser Leu Asn Pro Asn Asn Leu Glu Tyr Trp Met Glu Asp Ile
         855                 860                 865

 tat act cca gga tac gat tca tta cta aaa cgt aaa gaa gcc gaa ttc     2695
 Tyr Thr Pro Gly Tyr Asp Ser Leu Leu Lys Arg Lys Glu Ala Glu Phe
     870                 875                 880

 aga cga gcc aag gtc tgc aag ata gct gct ctg atc gct gct gcg gca     2743
 Arg Arg Ala Lys Val Cys Lys Ile Ala Ala Leu Ile Ala Ala Ala Ala
 885                 890                 895                 900

 tgc acc gtc atc ctc gtt att gtc gtg ccc atc tgc aca atg aaa tca     2791
 Cys Thr Val Ile Leu Val Ile Val Val Pro Ile Cys Thr Met Lys Ser
                 905                 910                 915

 tga gcta agaatgcaac cttacgtaca gcttatgact accaatgtcg tcgtctgtat     2848
 






      <210> 180
      <211> 2102
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1735)..(1923)

      <220>
      <221> misc_feature
      <222> (1)...(2102)
      <223> n = a,t,c or g

      <400> 180
 ttcactctct gaagatgatc atttgccctt aaggacaaaa atgaactgaa gtttcacatg     60

 agctatttcc attccagaat atctgggatt ctactttaag cactacataa actgacttta    120

 tcctcagact agctgaatga ttttgtgctg tttcaggatg tttgcactga agaaaaacag    180

 aaagcttatc tgaaatttat aaaacttttt gttttgctac atagaaaaca gaaggtattt    240

 gaataataag cagtgatatg cttagtgagc acagctatac tgattttgat tagaatagtc    300

 atcagagtgg cttagggaca gttaatataa aagaggagca aggtgtagac catcatctac    360

 ttctgctaaa ataacttaaa aagaggtcca taggccataa ctacatgagc ccagcttttg    420

 taatctgaca aaaaaatgag gagcagcttc gtgtatatca gtgtacacgg tattccttag    480

 gtcccttcca ttggtagtga tgctgcgagt tattactgga gaaaaggaat tctagagctt    540

 taacttggca gattaaaagt actcattttt tattcatcaa taattagtaa tctcactagt    600

 tttcaaaaat ttgcatatta ttgacaacct ctttgaagat gcatttcaca aactcaacag    660

 agtgccatga taagagctag ggatccccca aactatctca agcatctaaa aaattgccat    720

 ttttaaaggc ttaaattgta gtagtaaagg ggaaaacagg aagtagtagt aaaggggaaa    780

 aaaaaccaat aaagcatcta aaaaattggc atgttaaaag gcttaaattg ctaatgtgta    840

 tgtatatata tatatatata cacacacata tacacacaca tatcattgac ttttcttaag    900

 acttcagagt actgggtaga tgaacacttt atacagtata tatcttcagc ttaaatttgt    960

 tttgagtatt ttttttttat ttttaaataa gtaggcaaag atttaaattt ttttattttt   1020

 agtaaatgtt tgaggcacac taaaaagact tgggcaatat ttaccaaaac aaaacagaac   1080

 ccaaaaaatt gtacatcttg atcttagcaa atatccttat tgtagagaca cttaataaag   1140

 agatggtatt ttaatatctg cagttctgag gtagggtgta acttagttct acattgtgat   1200

 ttaggaattt ttaaaccttt cttcttcagg ggagaagtga cccaggcctc gagtttagtg   1260

 ctaaagccac tagtgtactt atgctgtcac ctaaccacca catgcgacat ggaggcagag   1320

 gctaaatata ggggctttct taagaaagtg agaggaaatt agcaagcatt attagtgttt   1380

 gactactgct atcaagtgaa ttcaaaggaa acaggttttt atgccatatt taagttacag   1440

 aaaccaggca tgcttagaat agtttctaga ggttattgga gaatagaaag ctaagaaaac   1500

 ttggtataca tttacaatgg aaatataatt acacttttta ctctcagaat attgttcaca   1560

 ttagacttcc tgtttatctt ttatattctt gcatttatat aatgcctcat cctttcaaag   1620

 ttctttcaca tattatatga tcttctttat gaaaaaaata gatgctttat tctgatatat   1680

 tcagtttccc actttaggca aaagtggatt aatagaatga tgaattcaaa gtag  atg    1737
                                                              Met
                                                                1

 agg aaa atc agg cac aga gaa gta aag gta ggt aca gac cca aat tca     1785
 Arg Lys Ile Arg His Arg Glu Val Lys Val Gly Thr Asp Pro Asn Ser
               5                  10                  15

 cac aag ata atg aca tca cca gcg ttt aag ttg atc atc aaa ggc tgg     1833
 His Lys Ile Met Thr Ser Pro Ala Phe Lys Leu Ile Ile Lys Gly Trp
          20                  25                  30

 gct gga ttt gtc ttg ctg tat gtg tca gga aat tta tac cta tta cat     1881
 Ala Gly Phe Val Leu Leu Tyr Val Ser Gly Asn Leu Tyr Leu Leu His
      35                  40                  45

 ttt cca ttt tct caa aat aag tca cat gat tgt aat gtt tag ctgcaac     1930
 Phe Pro Phe Ser Gln Asn Lys Ser His Asp Cys Asn Val 
  50                  55                  60

 ttttctccta ataaatagtg tcatgaaagn tgggtatagt gcaagtttgt acatttcang   1990

 ggtcagtatt acaatgtgaa ctctttatct acgggaatga gaaattgaga tcattgangg   2050

 ccctgaatta aacaaaattt gcatgtgaag cctgtttaaa acttggtcca ag           2102




      <210> 181
      <211> 1096
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(516)

      <220>
      <221> misc_feature
      <222> (1)...(1096)
      <223> n = a,t,c or g

      <400> 181
 tggaagggcg aatgctctgg naagttttgc ggcagaataa ctgggagata tgggaaagga     60

 agacgctaca agcgcgcaga atccttccaa aggccacacg ttgcccaccc accccaatct    120

 ctgaaccatg aggccaccct gaggtgctgg gcc atg ggc ttt tac ctg cgg aag     174
                                      Met Gly Phe Tyr Leu Arg Lys
                                        1               5

 atc acg ctg acc tgg cag cgg gat ggg gag gaa cag acc cag gac aca      222
 Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Glu Gln Thr Gln Asp Thr
          10                  15                  20

 gag ctt gtg gag acc agg cct gca ggg gat gga acc ttc cag aag tgg      270
 Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp
      25                  30                  35

 gcc gct gtg gtg gtg cct cct gga gag gaa cag aga tac aca tgc cat      318
 Ala Ala Val Val Val Pro Pro Gly Glu Glu Gln Arg Tyr Thr Cys His
  40                  45                  50                  55

 gtg cag cac gag ggg ctg ccc cag ccc ctc atc ctg aga tgg gag cag      366
 Val Gln His Glu Gly Leu Pro Gln Pro Leu Ile Leu Arg Trp Glu Gln
                  60                  65                  70

 tct ccc cag ccc acc atc ccc atc gtg ggc atc gtt gct ggc ctt gtt      414
 Ser Pro Gln Pro Thr Ile Pro Ile Val Gly Ile Val Ala Gly Leu Val
              75                  80                  85

 gtc ctt gga gct gtg gtc act gga gct gtg gtc gct gct gtg atg tgg      462
 Val Leu Gly Ala Val Val Thr Gly Ala Val Val Ala Ala Val Met Trp
          90                  95                 100

 agg aag aag agc tca gat aga aac aga ggg agc tac tct cag gct gca      510
 Arg Lys Lys Ser Ser Asp Arg Asn Arg Gly Ser Tyr Ser Gln Ala Ala
     105                 110                 115

 gtg tga gacagcttcc ttgtgtggga ctgagaagca agatatcaat gtagcagaat       566
 Val 
 120

 tgcacttgtg cctcacgaac atacataaat ttaaaaaata aagaataaaa atataaaaac    626

 tcatttgtaa agctcctgtg aaaatgaagg acagattctt cacttcgatg attatggtgg    686

 tgatgggacc tgatcccagc agtcacaaat cacaggggaa ggtccctgct gatgacagac    746

 ctcaggaggg cagttggtcc aggacccaca tctgctttct tcatatttct tgatcctgcc    806

 ctggatctac agttacactt ttctggaaac ttctctggga tcaaagacta ggggtttgct    866

 ctaggacctt atggccctgc ctcctttctg gcctctcaca ggacattttc ttcccataga    926

 tagaaacaga gggagctact ctcaggctgc agtgtgagac agcttccttg tgtgggactg    986

 agaagcaaga tatcaatgta gcagaattgc acttgtgcct cacgaacata cataaatttt   1046

 aaaaataaag aataaaaata tatcttttta tagataaaaa aaaaaaaaaa              1096




      <210> 182
      <211> 1131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (424)..(1131)

      <400> 182
 gttacattag catacaaaaa tagtctttta aacacattgt taaccactac atatacaaac     60

 attgaaatcg ggaacactgg taccaattac tgacacttaa attacgaatc agctttacct    120

 atactatatg gagaagttct gtgctctcaa tatttctctc aagacctcaa aagtcatcct    180

 tgtgcgaccc aatcagatat tttttcaaaa tatgatagaa acatgttcaa ccaatagcca    240

 caaaagtagt agcctcagga gactcattct cgcagtgaat tgggcatgca ccaaattcca    300

 ggcaagatga ggagacattg tggaagatgc tctccttctt ttaagccaaa gagacgtcaa    360

 taattgtggc atattattaa ttagtgcctt attcctctac aatttttttc agagaggtca    420

 gga  atg gtt gaa gaa aat cat acc atg aaa aat gag ttt atc ctc aca     468
      Met Val Glu Glu Asn His Thr Met Lys Asn Glu Phe Ile Leu Thr
        1               5                  10                  15

 gga ttt aca gat cac cct gag ctg aag act ctg ctg ttt gtg gtg ttc      516
 Gly Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe
                  20                  25                  30

 ttt gcc atc tat ctg atc acc gtg gtg ggg aat att agt ttg gtg gca      564
 Phe Ala Ile Tyr Leu Ile Thr Val Val Gly Asn Ile Ser Leu Val Ala
              35                  40                  45

 ctg ata ttt aca cac tgt cgg ctt cac aca cca atg tac atc ttt ctg      612
 Leu Ile Phe Thr His Cys Arg Leu His Thr Pro Met Tyr Ile Phe Leu
          50                  55                  60

 gga aat ctg gct ctt gtg gat tct tgc tgt gcc tgt gct att acc ccc      660
 Gly Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro
      65                  70                  75

 aaa atg tta gag aac ttc ttt tct gag ggc aaa agg att tcc ctc tat      708
 Lys Met Leu Glu Asn Phe Phe Ser Glu Gly Lys Arg Ile Ser Leu Tyr
  80                  85                  90                  95

 gaa tgt gca gta cag ttt tat ttt ctt tgc act gtg gaa act gca gac      756
 Glu Cys Ala Val Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp
                 100                 105                 110

 tgc ttt ctt ctg gca gca gtg gcc tat gac cgc tat gtg gcc atc tgc      804
 Cys Phe Leu Leu Ala Ala Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys
             115                 120                 125

 aac cca ctg cag tac cac atc atg atg tcc aag aaa ctc tgc att cag      852
 Asn Pro Leu Gln Tyr His Ile Met Met Ser Lys Lys Leu Cys Ile Gln
         130                 135                 140

 atg acc aca ggc gcc ttc ata gct gga aat ctg cat tcc atg att cat      900
 Met Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His
     145                 150                 155

 gta ggg ctt gta ttt agg tta gtt ttc tgt gga tcg aat cac atc aac      948
 Val Gly Leu Val Phe Arg Leu Val Phe Cys Gly Ser Asn His Ile Asn
 160                 165                 170                 175

 cac ttt tac tgt gat att ctt ccc ttg tat aga ctc tct tgt gtt gat      996
 His Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp
                 180                 185                 190

 cct tat atc aat gaa ctg gtt cta ttc atc ttc tca ggt tca gtt caa     1044
 Pro Tyr Ile Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Val Gln
             195                 200                 205

 gtc ttt acc ata ggg atg ata agc atc caa aag aac aca gca aaa ctg     1092
 Val Phe Thr Ile Gly Met Ile Ser Ile Gln Lys Asn Thr Ala Lys Leu
         210                 215                 220

 gaa gtt aca agt tca aag gac cat tcc att aag cat tga                 1131
 Glu Val Thr Ser Ser Lys Asp His Ser Ile Lys His 
     225                 230                 235





      <210> 183
      <211> 2102
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (201)..(1613)

      <400> 183
 cgacacgagg cgaagaagaa tctgagagaa acctgctgct ttcacagagg aaggcatttg     60

 ctggctttcc caaggcaaga acaatgaaaa caaactcatg atgagttctt tctacctcaa    120

 atgaaggcca caccacttgt tctgagtcca gtggcagtct gagagaacag tacattctga    180

 accacattga cgcagggagc    atg ggt atc tgg acc tca ggc act gat atc     230
                          Met Gly Ile Trp Thr Ser Gly Thr Asp Ile
                            1               5                  10

 ttc cta agt ctt tgg gag att tac gtg tct cca aga agc ccc gga tgg      278
 Phe Leu Ser Leu Trp Glu Ile Tyr Val Ser Pro Arg Ser Pro Gly Trp
                  15                  20                  25

 atg gac ttt atc cag cat ttg gga gtt tgc tgt ttg gtt gct ctt att      326
 Met Asp Phe Ile Gln His Leu Gly Val Cys Cys Leu Val Ala Leu Ile
              30                  35                  40

 tca gtg ggc ctc ctg tct gtg gcc gcc tgc tgg ttt ctg cca tca atc      374
 Ser Val Gly Leu Leu Ser Val Ala Ala Cys Trp Phe Leu Pro Ser Ile
          45                  50                  55

 ata gcg gcc gct gcc tcc tgg att atc acg tgt gtt ctg ctg tgt tgc      422
 Ile Ala Ala Ala Ala Ser Trp Ile Ile Thr Cys Val Leu Leu Cys Cys
      60                  65                  70

 tcc aag cat gca cga tgt ttt att ctt ctt gtc ttt ctc tct tgt ggc      470
 Ser Lys His Ala Arg Cys Phe Ile Leu Leu Val Phe Leu Ser Cys Gly
  75                  80                  85                  90

 ctg cgt gaa ggc agg aat gct ttg att gca gct ggc aca ggg atc gtc      518
 Leu Arg Glu Gly Arg Asn Ala Leu Ile Ala Ala Gly Thr Gly Ile Val
                  95                 100                 105

 atc ttg gga cac gta gaa aat att ttt cac aac ttt aaa ggt ctc cta      566
 Ile Leu Gly His Val Glu Asn Ile Phe His Asn Phe Lys Gly Leu Leu
             110                 115                 120

 gat ggt atg act tgc aac cta agg gca aag agc ttt tcc ata cat ttt      614
 Asp Gly Met Thr Cys Asn Leu Arg Ala Lys Ser Phe Ser Ile His Phe
         125                 130                 135

 cca ctt ttg aaa aaa tat att gag gca att cag tgg att tat ggc ctt      662
 Pro Leu Leu Lys Lys Tyr Ile Glu Ala Ile Gln Trp Ile Tyr Gly Leu
     140                 145                 150

 gcc act cca cta agt gta ttt gat gac ctt gtt tct tgg aac cag acc      710
 Ala Thr Pro Leu Ser Val Phe Asp Asp Leu Val Ser Trp Asn Gln Thr
 155                 160                 165                 170

 ctg gca gtc tct ctt ttc agt ccc agc cat gtc ctg gag gca cag cta      758
 Leu Ala Val Ser Leu Phe Ser Pro Ser His Val Leu Glu Ala Gln Leu
                 175                 180                 185

 aat gac agc aaa ggg gaa gtc ctg agc gtc ttg tac cag atg gca aca      806
 Asn Asp Ser Lys Gly Glu Val Leu Ser Val Leu Tyr Gln Met Ala Thr
             190                 195                 200

 acc aca gag gtg ttg tcc tcc ctg ggt cag aag cta ctt gcc ttt gca      854
 Thr Thr Glu Val Leu Ser Ser Leu Gly Gln Lys Leu Leu Ala Phe Ala
         205                 210                 215

 ggg ctt tcg ctc gtc ctg ctt ggc act ggc ctc ttc atg aag cga ttt      902
 Gly Leu Ser Leu Val Leu Leu Gly Thr Gly Leu Phe Met Lys Arg Phe
     220                 225                 230

 ttg ggc cct tgt ggt tgg aag tat gaa aac atc tac atc acc aga caa      950
 Leu Gly Pro Cys Gly Trp Lys Tyr Glu Asn Ile Tyr Ile Thr Arg Gln
 235                 240                 245                 250

 ttt gtt cag ttt gat gaa agg gag aga cat caa cag agg ccc tgt gtg      998
 Phe Val Gln Phe Asp Glu Arg Glu Arg His Gln Gln Arg Pro Cys Val
                 255                 260                 265

 ctc ccg ctg aat aag gag gaa agg agg aag tat gtc atc atc ccg act     1046
 Leu Pro Leu Asn Lys Glu Glu Arg Arg Lys Tyr Val Ile Ile Pro Thr
             270                 275                 280

 ttc tgg ccg act cct aaa gaa agg aaa aac ctg ggg ctg ttt ttc ctc     1094
 Phe Trp Pro Thr Pro Lys Glu Arg Lys Asn Leu Gly Leu Phe Phe Leu
         285                 290                 295

 ccc ata ctt atc cat ctc tgc atc tgg gtg ctg ttt gca gct gta gat     1142
 Pro Ile Leu Ile His Leu Cys Ile Trp Val Leu Phe Ala Ala Val Asp
     300                 305                 310

 tat ctg ctg tat cgg ctc att ttc tca gtg agc aag cag ttt caa agc     1190
 Tyr Leu Leu Tyr Arg Leu Ile Phe Ser Val Ser Lys Gln Phe Gln Ser
 315                 320                 325                 330

 ttg cca ggg ttt gag gtt cac ttg aaa ctg cac gga gag aaa caa gga     1238
 Leu Pro Gly Phe Glu Val His Leu Lys Leu His Gly Glu Lys Gln Gly
                 335                 340                 345

 act caa gat att atc cat gat tct tcc ttt aat ata tct gtg ttt gaa     1286
 Thr Gln Asp Ile Ile His Asp Ser Ser Phe Asn Ile Ser Val Phe Glu
             350                 355                 360

 ccc aac tgt atc cca aaa cca aaa ttc ctt cta tct gag acc tgg gtt     1334
 Pro Asn Cys Ile Pro Lys Pro Lys Phe Leu Leu Ser Glu Thr Trp Val
         365                 370                 375

 cct ctc agt gtt att ctt ttg ata tta gtg atg ctg gga ctg ttg tcc     1382
 Pro Leu Ser Val Ile Leu Leu Ile Leu Val Met Leu Gly Leu Leu Ser
     380                 385                 390

 tct atc ctt atg caa ctt aaa atc ctg gtg tca gca tct ttc tac ccc     1430
 Ser Ile Leu Met Gln Leu Lys Ile Leu Val Ser Ala Ser Phe Tyr Pro
 395                 400                 405                 410

 agc gtg gag agg aag cgc atc caa tat ctg cat gca aag ctg ctt aaa     1478
 Ser Val Glu Arg Lys Arg Ile Gln Tyr Leu His Ala Lys Leu Leu Lys
                 415                 420                 425

 aaa aga tca aag cag ccg ctg gga gaa gtc aaa aga cgg ctg agt ctc     1526
 Lys Arg Ser Lys Gln Pro Leu Gly Glu Val Lys Arg Arg Leu Ser Leu
             430                 435                 440

 tat ctt aca aag att cat ttc tgg ctt cca gtc ctg aaa atg att agg     1574
 Tyr Leu Thr Lys Ile His Phe Trp Leu Pro Val Leu Lys Met Ile Arg
         445                 450                 455

 aag aag caa atg gac atg gca agt gca gac aag tca tga gagaccccga      1623
 Lys Lys Gln Met Asp Met Ala Ser Ala Asp Lys Ser 
     460                 465                 470

 ctactcctca gccacatcgc accaacaatt ctcttcaggt ctaggatggc agtcactatt   1683

 catgccggat aatagagaac tatgtgacgc agtcctctca ggagtctgag tttacagagc   1743

 caacttgcag cacctggtta tgcctccttt catctcaaag ccaaagagct gccaggtaaa   1803

 tggttatgtg gtctatgttc caaacaaacc acatgatctt gcctgtgtca caatgtaaca   1863

 agactctagc tgggtcccct ggtgatgagt ttcagcatag aataatgttc aaggaaaaga   1923

 aaacgaaaac agtttaaatc tctaccacag cctcacaagc aaatgctaag gggaacatac   1983

 atgtaaaaag ccagcaaact atcttcaaac tcttccgtcc ttaatgtctt ccatggctat   2043

 tgcccccaca atggtctctt ttctccctgc tcccttatta aagaactctt tctgaaacc    2102




      <210> 184
      <211> 893
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(502)

      <400> 184
 gcgggcggaa tccaggcggg cc atg gcg gat gtc ccc ggg gca cag cga gcg      52
                          Met Ala Asp Val Pro Gly Ala Gln Arg Ala
                            1               5                  10

 gtt cct ggt gac ggc cca gag ccc cgg gac ccc ctg gac tgt tgg gcc      100
 Val Pro Gly Asp Gly Pro Glu Pro Arg Asp Pro Leu Asp Cys Trp Ala
                  15                  20                  25

 tgc gct gtt ctt gta aca gcc cag aat ctg ctg gtg gct gcc ttc aat      148
 Cys Ala Val Leu Val Thr Ala Gln Asn Leu Leu Val Ala Ala Phe Asn
              30                  35                  40

 ctt ctc ctg ctg gtg ctg gtg cta ggg acc atc ttg cta ccc gct gtc      196
 Leu Leu Leu Leu Val Leu Val Leu Gly Thr Ile Leu Leu Pro Ala Val
          45                  50                  55

 acc atg ctg ggc ttc ggc ttc ctc tgc cac tct cag ttc ctg cgc tcc      244
 Thr Met Leu Gly Phe Gly Phe Leu Cys His Ser Gln Phe Leu Arg Ser
      60                  65                  70

 cag gca ccc cct tgc acc gcg cac ctg cgg gac ccc ggt ttc acg gcc      292
 Gln Ala Pro Pro Cys Thr Ala His Leu Arg Asp Pro Gly Phe Thr Ala
  75                  80                  85                  90

 cta ctg gtc acc gga ttc ctg ctc ctc gtg ccg ctg ctc gtg ctt gct      340
 Leu Leu Val Thr Gly Phe Leu Leu Leu Val Pro Leu Leu Val Leu Ala
                  95                 100                 105

 ctg gcc agc tac cgc cgc ctc tgc ctg cgc ctc cgc cta gcc gat tgc      388
 Leu Ala Ser Tyr Arg Arg Leu Cys Leu Arg Leu Arg Leu Ala Asp Cys
             110                 115                 120

 ctc gtg ccc tac agc cga gcc ctt tat cgg cgt cgg cgc gcc ccg cag      436
 Leu Val Pro Tyr Ser Arg Ala Leu Tyr Arg Arg Arg Arg Ala Pro Gln
         125                 130                 135

 ccg cgg caa atc cgg gcc tca cca ggg tcc cag gcc gtt ccc aca tca      484
 Pro Arg Gln Ile Arg Ala Ser Pro Gly Ser Gln Ala Val Pro Thr Ser
     140                 145                 150

 gga aag gtc tgg gtc taa tgaccc tcgagtcaag aacaaccctg acggctgccc      538
 Gly Lys Val Trp Val 
 155

 tccctcttat tcggcccaag gacttgaagc ccggcatctt ccgacctgcc ctgcccccac    598

 ccctgcctga gcggagtcct agcatcccct tgggagcagc agcgtcagtg gacccagtgc    658

 tgagaaaagc ccccacatcc cggaaaaccc actttccttt cacgacccac atctcaatcc    718

 tgaacatcta ggctggaacc tgcacacctc cccctcagct ccgtcgtgaa tgggacaaca    778

 atctcgtgcc ctcgttttat ggtgcagctt ctctagtatt tctggggctg gggggcgggg    838

 ctggagggga aggagtgtcc acgcatcaat aaagatttaa cgaacaaaaa aaaaa         893




      <210> 185
      <211> 1633
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (658)..(1374)

      <400> 185
 cacctcatca gcaccactac tgcaccaaat gaagtgtcag agacagacac catccgaagc     60

 cctccagatg ggtgtcggcg cggagccgcc tcgggccggg ccgagggctg cgcggcggcg    120

 gcggcggcgg ggcccggcca ggatgcgggg ctcccgggac cgcgcggggc ggggcgggcg    180

 gcggcggcgg gctgcgggcg ggagctgtcc gcggtgctga agcggcggct gctcagggac    240

 gcggggacga gagcagggga gccctcctgg gagttccacc gcgaccgcga ggcgggggcg    300

 ccgtcgctca ccggcccatg ccgagccccc gagccccgcg gaggaggcgg gaccgtccgc    360

 ggcgggacag gaatctgtgc tgggtctcca ggatcacgtc cgcgaactcc ccatgtggcc    420

 ctagtaggat atggggtgag tatgagctgt gtagagaacc atgacccttg gctggactgt    480

 gagcagatgc agctgctgct aactcagatt gctttatgga agaagaggta tctttccatc    540

 cctcctggag agatcagaca ggagggcagt cctcctggtg agacagagcg tagggcaggg    600

 gctctgagga ctgctcagct ggcccaggcc cccctcccca gcagctgccc cagaacc       657                                                                 
 atg gag agt ctg agt gaa cta cag aac ccg ctg ctg ccc agg agc cct      705
 Met Glu Ser Leu Ser Glu Leu Gln Asn Pro Leu Leu Pro Arg Ser Pro
   1               5                  10                  15

 gcc cat ctc cat ggc ccc tat ccc tac ccg gag acc cca ccc agc tgg      753
 Ala His Leu His Gly Pro Tyr Pro Tyr Pro Glu Thr Pro Pro Ser Trp
              20                  25                  30

 tcc tgc cag gaa aag ctc tac tcc tac ctc cta ggt ggc gct ggg cct      801
 Ser Cys Gln Glu Lys Leu Tyr Ser Tyr Leu Leu Gly Gly Ala Gly Pro
          35                  40                  45

 gcc gga gcc cac cag ctc ctg gac cca ggg tcc ctg cag ctg gcc gtg      849
 Ala Gly Ala His Gln Leu Leu Asp Pro Gly Ser Leu Gln Leu Ala Val
      50                  55                  60

 gag gcc tgg tac cgg ccc agc tgc ctc ctg ggg aga gac aag gtc aag      897
 Glu Ala Trp Tyr Arg Pro Ser Cys Leu Leu Gly Arg Asp Lys Val Lys
  65                  70                  75                  80

 gag ccc agg gca ggc agc tgt gag aca agc ttc aca gag gac agg gag      945
 Glu Pro Arg Ala Gly Ser Cys Glu Thr Ser Phe Thr Glu Asp Arg Glu
                  85                  90                  95

 ccc cag gag ggg cct cca gag cag ccc aca gga cct ggc caa gct gca      993
 Pro Gln Glu Gly Pro Pro Glu Gln Pro Thr Gly Pro Gly Gln Ala Ala
             100                 105                 110

 gag aat gtc acc atc cag act gtg tcc tat ggg gta caa gag gag ctg     1041
 Glu Asn Val Thr Ile Gln Thr Val Ser Tyr Gly Val Gln Glu Glu Leu
         115                 120                 125

 cgg gac cag gag gat gac cag gag gaa gag gag agc gat gcc act tca     1089
 Arg Asp Gln Glu Asp Asp Gln Glu Glu Glu Glu Ser Asp Ala Thr Ser
     130                 135                 140

 acg gag agt gaa agt gaa gac aac ttc ctc acg ctg cct ccc agg gac     1137
 Thr Glu Ser Glu Ser Glu Asp Asn Phe Leu Thr Leu Pro Pro Arg Asp
 145                 150                 155                 160

 cac ctg gga ctt act ctc ttc tcc atg ctc tgc tgc ttc tgg cca ctg     1185
 His Leu Gly Leu Thr Leu Phe Ser Met Leu Cys Cys Phe Trp Pro Leu
                 165                 170                 175

 ggc att gct gcc ttc tac ttc tcc cag ggg acc agc aag gcc atc tcc     1233
 Gly Ile Ala Ala Phe Tyr Phe Ser Gln Gly Thr Ser Lys Ala Ile Ser
             180                 185                 190

 aaa ggg gac ttc cgc ctg gcc agc acc acc tcc cgc cgg gcc ctc ttc     1281
 Lys Gly Asp Phe Arg Leu Ala Ser Thr Thr Ser Arg Arg Ala Leu Phe
         195                 200                 205

 cta gcc aca ctc gcc atc gcc gtg ggg gcc ggt ctc tac gtg gct gtg     1329
 Leu Ala Thr Leu Ala Ile Ala Val Gly Ala Gly Leu Tyr Val Ala Val
     210                 215                 220

 gtg gtg gct ctg gca gct tac atg tcc cag aac ggt cat ggc tag tag     1377
 Val Val Ala Leu Ala Ala Tyr Met Ser Gln Asn Gly His Gly 
 225                 230                 235

 ccagtagggc ctgcatcctg actcccctgc ccacctgagg aagcagtggg gcttggagtt   1437

 gcagacccta tggaaaggcc cggcccctga agatgatccc gtgagagtgg cttgctgagg   1497

 gggagacccc cattccacag cctgcagagc tcagccttca cttctgcttg cccgctgctc   1557

 ccagccccag agcagggccc ggggcgccac tctctaaccc aggctacaga cgggaaacag   1617

 aaggcagggc tgccca                                                   1633




      <210> 186
      <211> 2400
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(2362)

      <400> 186
 cgactctcta tagggcaagc agtggtacac gcagagtacg cgggggggaa ggcggcgccc     60

 cggccgaggt ggcggcggct cctcaggacg gaagctcctg ttttcttgtc agccgccagc    120

 tgagggccat tcgcagcttc tccaggccac ctgcattcct tgtctcagag cctccctcct    180

 gcatcctcca agccagcagt tgtgggatgg gagaagaagt tgtccatgtt cacactgggt    240

 gaaggaagct gaaaccacag ac atg act gag tcc tcc atg aag aag ctg gcc     292
                          Met Thr Glu Ser Ser Met Lys Lys Leu Ala
                            1               5                  10

 tcc acc ctg ctg gac gcc atc acc gat aag gac ccc ctg gtg cag gag      340
 Ser Thr Leu Leu Asp Ala Ile Thr Asp Lys Asp Pro Leu Val Gln Glu
                  15                  20                  25

 cag gtc tgc agt gcc ctg tgc tcc ctc ggg gag gtg cgg ccg gtg gag      388
 Gln Val Cys Ser Ala Leu Cys Ser Leu Gly Glu Val Arg Pro Val Glu
              30                  35                  40

 acg ctc cgt gcc tgc gag gag tat ctg cgg cag cat gac aag ctg gca      436
 Thr Leu Arg Ala Cys Glu Glu Tyr Leu Arg Gln His Asp Lys Leu Ala
          45                  50                  55

 cac cca tac cga gca gcg gtc ctg agg gcc atg gag agg gtc ctg agc      484
 His Pro Tyr Arg Ala Ala Val Leu Arg Ala Met Glu Arg Val Leu Ser
      60                  65                  70

 agt cgc gcc agt gag ctg gac aag gac aca gcc agc acc atc atc ctc      532
 Ser Arg Ala Ser Glu Leu Asp Lys Asp Thr Ala Ser Thr Ile Ile Leu
  75                  80                  85                  90

 ctg gcc tcc agc gag atg acc aag acg aag gac ctg gtc tgg gac tgg      580
 Leu Ala Ser Ser Glu Met Thr Lys Thr Lys Asp Leu Val Trp Asp Trp
                  95                 100                 105

 cag cag gcg gcg agt ggc gtc ctg gtg gcc gtg gga aga cag ttc atc      628
 Gln Gln Ala Ala Ser Gly Val Leu Val Ala Val Gly Arg Gln Phe Ile
             110                 115                 120

 agc aag gtg atg gag gag ctg ctg cgc agg ctg cac cct ggg acc ctg      676
 Ser Lys Val Met Glu Glu Leu Leu Arg Arg Leu His Pro Gly Thr Leu
         125                 130                 135

 cca cac tgc gcc gtg ctg cac acc ctc gcc agc ctc tcg gtg gcc aac      724
 Pro His Cys Ala Val Leu His Thr Leu Ala Ser Leu Ser Val Ala Asn
     140                 145                 150

 gcg ttc ggc gta gtc ccc ttc ctg cca tcc gtc ctg agc tcc ctg ctg      772
 Ala Phe Gly Val Val Pro Phe Leu Pro Ser Val Leu Ser Ser Leu Leu
 155                 160                 165                 170

 ccc gtg ctg ggc gtg gcc aag cag gac acg gtg cgc gtg gcc ttc tgc      820
 Pro Val Leu Gly Val Ala Lys Gln Asp Thr Val Arg Val Ala Phe Cys
                 175                 180                 185

 tcc gct ctg cag cgc ttc agc gag ggt gcc ctg gag tac cta gcc aac      868
 Ser Ala Leu Gln Arg Phe Ser Glu Gly Ala Leu Glu Tyr Leu Ala Asn
             190                 195                 200

 ctg gac cga gcc cca gac ccc acg gtc agg aag gac gcc ttt gcc acc      916
 Leu Asp Arg Ala Pro Asp Pro Thr Val Arg Lys Asp Ala Phe Ala Thr
         205                 210                 215

 gac atc ttc agc gcc tac gat gtt ctc ttc cat cag tgg ctg cag agt      964
 Asp Ile Phe Ser Ala Tyr Asp Val Leu Phe His Gln Trp Leu Gln Ser
     220                 225                 230

 cga gaa gcc aag ctc cgt ctt gcc gtg gtg gag gct ctg ggg cct atg     1012
 Arg Glu Ala Lys Leu Arg Leu Ala Val Val Glu Ala Leu Gly Pro Met
 235                 240                 245                 250

 agc cat ctg ctg ccc agt gag agg ctg gaa gag cag ctg ccc aag ctc     1060
 Ser His Leu Leu Pro Ser Glu Arg Leu Glu Glu Gln Leu Pro Lys Leu
                 255                 260                 265

 ctc cct ggg att ctc gcc ctc tac aag aag cac gca gag acc ttc tac     1108
 Leu Pro Gly Ile Leu Ala Leu Tyr Lys Lys His Ala Glu Thr Phe Tyr
             270                 275                 280

 ttg tcc aag agc ctg ggc cag atc ctc gag gca gct gtg agt gtg ggc     1156
 Leu Ser Lys Ser Leu Gly Gln Ile Leu Glu Ala Ala Val Ser Val Gly
         285                 290                 295

 agc cgc aca ctg gag acc cag ctg gat gcc ctc ttg gct gca ctg cac     1204
 Ser Arg Thr Leu Glu Thr Gln Leu Asp Ala Leu Leu Ala Ala Leu His
     300                 305                 310

 tcc cag atc tgt gtg cct gtg gag tcc tca agc ccc ctg gtg atg agt     1252
 Ser Gln Ile Cys Val Pro Val Glu Ser Ser Ser Pro Leu Val Met Ser
 315                 320                 325                 330

 aac cag aag gag gtg ctg cgc tgc ttc act gtg ctg gcc tgc agc tcg     1300
 Asn Gln Lys Glu Val Leu Arg Cys Phe Thr Val Leu Ala Cys Ser Ser
                 335                 340                 345

 cct gac cgc cta ctg gcc ttc ctg ctg ccc agg ctg gac acc agc aat     1348
 Pro Asp Arg Leu Leu Ala Phe Leu Leu Pro Arg Leu Asp Thr Ser Asn
             350                 355                 360

 gag agg acc cgc gtg ggc acc ctg cag gtg gtc aga cat gtc atc aac     1396
 Glu Arg Thr Arg Val Gly Thr Leu Gln Val Val Arg His Val Ile Asn
         365                 370                 375

 tca gct gct gct cag atg gaa gat aaa aag ccc ttt atc ctg tct tcc     1444
 Ser Ala Ala Ala Gln Met Glu Asp Lys Lys Pro Phe Ile Leu Ser Ser
     380                 385                 390

 atg agg ctt cct ctc ctg gac acc aac agc aag gtg aag cgg gca gtg     1492
 Met Arg Leu Pro Leu Leu Asp Thr Asn Ser Lys Val Lys Arg Ala Val
 395                 400                 405                 410

 gtg cag gtg att agc gcc atg gcc cac cac ggc tac ctg gag cag cct     1540
 Val Gln Val Ile Ser Ala Met Ala His His Gly Tyr Leu Glu Gln Pro
                 415                 420                 425

 gga ggt gag gcg atg atc gag tac atc gtg cag cag tgc gcg ctg ccc     1588
 Gly Gly Glu Ala Met Ile Glu Tyr Ile Val Gln Gln Cys Ala Leu Pro
             430                 435                 440

 ccc gag cag gag cct gag gag cca ggc ccc ggc agc aag gac ccc aag     1636
 Pro Glu Gln Glu Pro Glu Glu Pro Gly Pro Gly Ser Lys Asp Pro Lys
         445                 450                 455

 gcc gac agc gtg cgg gcc atc agc gtg cgc acc ctc tac ctg gtc agc     1684
 Ala Asp Ser Val Arg Ala Ile Ser Val Arg Thr Leu Tyr Leu Val Ser
     460                 465                 470

 acc acc gtg gac agg atg agt cac gtc ctc tgg cca tac ctg ctc cag     1732
 Thr Thr Val Asp Arg Met Ser His Val Leu Trp Pro Tyr Leu Leu Gln
 475                 480                 485                 490

 ttc ctc acc cct gtg cgc ttc act ggg gcc ctg act ccg ctc tgc agg     1780
 Phe Leu Thr Pro Val Arg Phe Thr Gly Ala Leu Thr Pro Leu Cys Arg
                 495                 500                 505

 agc ctc gtg cat ctg gcg cac aag agg cag gag gcc ggg gcc gac gcc     1828
 Ser Leu Val His Leu Ala His Lys Arg Gln Glu Ala Gly Ala Asp Ala
             510                 515                 520

 ttc ctc atc cag tac gac gcc cat gcg agc ctc ccg tct ccc tat gct     1876
 Phe Leu Ile Gln Tyr Asp Ala His Ala Ser Leu Pro Ser Pro Tyr Ala
         525                 530                 535

 gta acc gga aga ctg ttg gtt gtg tct tcc agc ccc tac cta ggg gac     1924
 Val Thr Gly Arg Leu Leu Val Val Ser Ser Ser Pro Tyr Leu Gly Asp
     540                 545                 550

 gga cgt ggg gca gcg gcg ctg cgc ctc ctc agt gtt ctg cac cca aac     1972
 Gly Arg Gly Ala Ala Ala Leu Arg Leu Leu Ser Val Leu His Pro Asn
 555                 560                 565                 570

 att cac cct ttg ctg ggt cag cat tgg gaa acg act gtc ccg ctg ctg     2020
 Ile His Pro Leu Leu Gly Gln His Trp Glu Thr Thr Val Pro Leu Leu
                 575                 580                 585

 ctg ggg tac ctg gat gag cac aca gaa gag acc ctg cca cag gag gag     2068
 Leu Gly Tyr Leu Asp Glu His Thr Glu Glu Thr Leu Pro Gln Glu Glu
             590                 595                 600

 tgg gag gag aag ctg ttg atg ttc ctg cga gac acc ctg gcc atc att     2116
 Trp Glu Glu Lys Leu Leu Met Phe Leu Arg Asp Thr Leu Ala Ile Ile
         605                 610                 615

 tct gac aac gcg tgg atc tgc cag ctg agc ctg gag ctg tgc agg cag     2164
 Ser Asp Asn Ala Trp Ile Cys Gln Leu Ser Leu Glu Leu Cys Arg Gln
     620                 625                 630

 ctg ccc tgc tac gat gag gca ccc cag gag aag aac ttc ctg tac aaa     2212
 Leu Pro Cys Tyr Asp Glu Ala Pro Gln Glu Lys Asn Phe Leu Tyr Lys
 635                 640                 645                 650

 tgc ata ggc acc acc ctg ggt gct gtt tca agt aag gag gtg gtg agg     2260
 Cys Ile Gly Thr Thr Leu Gly Ala Val Ser Ser Lys Glu Val Val Arg
                 655                 660                 665

 aag cac ctt caa gag ctg ctg gag acg ggc aga tac cag gag gag gca     2308
 Lys His Leu Gln Glu Leu Leu Glu Thr Gly Arg Tyr Gln Glu Glu Ala
             670                 675                 680

 gaa cgc gag ggc ctc gcc tgc tgc ttc ggg atc tgt gcc atc tcc cac     2356
 Glu Arg Glu Gly Leu Ala Cys Cys Phe Gly Ile Cys Ala Ile Ser His
         685                 690                 695

 ctc tag gacacgctgt gccacatgta ggacttttcg agggcaca                   2400
 Leu 






      <210> 187
      <211> 2991
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (890)..(2395)

      <400> 187
 gtttgcaccc ctcgccctat ctaaacccag cgctaaaagt gctgtggtaa atatctctca     60

 cgatcattgc cgaccgctcc gataagatca gtggctcggt tataagtacc atgcaatgtg    120

 tcacagaata cggcgagttc atatctactc tcgattatga agatgctcat tttgcttaag    180

 gacgtgctag gtcccgagac agtcaaactc cgccatttca gtggccgttt caagattcgt    240

 tattttagcc gcaagaacag ttccattgtg tgtacgactg gtaccaccag aagtgtgtaa    300

 ggcccagtag ctcctctctt atttagggcc aaaggctcag tggcttggcc attttaaatg    360

 tgtgccttcc tttagagatt ttgatctttc cagatttcaa catttgggac tgtggtattt    420

 agcactgtgt cttttgaaat tatggcccaa acccctccca aggacaccct ggaaaccaac    480

 acaaaccaga gggtagggga aaagaaagga tggagaaggc atgtcttctt ctgacacata    540

 acacttctgc tcatattcca ctgatgacca ttcatcacag ggcctcaccc aaataggcat    600

 ggagctgaga atgtagtcac tgtccacgca gccaccttct gggtagaact ctacactctt    660

 gaaatgggaa tctccaagcc actgggggat agctggggaa ctagttctgc agactgtata    720

 ggcttctgct tctggggagg cctcaggaaa cttacaatca tggtggaagg caaaggggaa    780

 gcaggcatgt cttacatggc tggagcaaaa ggaagagagc aaaggggagg tgcttgtaaa    840

 caaccagatc tcggtgaatg tggacttcca gaagcagacg gtagatcct    atg caa     895
                                                          Met Gln
                                                            1

 gtc tcc ttt aac aca tca gac agg tcc cag aca gtt aca gat ctc ctt      943
 Val Ser Phe Asn Thr Ser Asp Arg Ser Gln Thr Val Thr Asp Leu Leu
           5                  10                  15

 cta act att gat gtc aca gag gtg gtt gaa gtg gga cac ttt tgg gga      991
 Leu Thr Ile Asp Val Thr Glu Val Val Glu Val Gly His Phe Trp Gly
      20                  25                  30

 tac agg att gat gaa aac aac tca gag att ctg aaa aag ctt act gct     1039
 Tyr Arg Ile Asp Glu Asn Asn Ser Glu Ile Leu Lys Lys Leu Thr Ala
  35                  40                  45                  50

 gaa atc aac caa ctg acg ctg gtg ccc ttg ccc act cac cca cat cca     1087
 Glu Ile Asn Gln Leu Thr Leu Val Pro Leu Pro Thr His Pro His Pro
                  55                  60                  65

 gac ttg gtc tgt ctg gca cct ttt gct gat ttt gat aaa caa cgc tac     1135
 Asp Leu Val Cys Leu Ala Pro Phe Ala Asp Phe Asp Lys Gln Arg Tyr
              70                  75                  80

 ttt aga gct caa gtc ctt tat gtt tct gga aat tct gct gag gta ttc     1183
 Phe Arg Ala Gln Val Leu Tyr Val Ser Gly Asn Ser Ala Glu Val Phe
          85                  90                  95

 ttt gta gat tat ggc aat aag tct cat gta gat cta cat ctt ttg atg     1231
 Phe Val Asp Tyr Gly Asn Lys Ser His Val Asp Leu His Leu Leu Met
     100                 105                 110

 gag att ccc tgt caa ttt ctt gaa ctt cct ttc cag gct ttg gaa ttt     1279
 Glu Ile Pro Cys Gln Phe Leu Glu Leu Pro Phe Gln Ala Leu Glu Phe
 115                 120                 125                 130

 aag att tgc aaa atg aga cca tca gca aag tct ctt gtt tgt ggc aag     1327
 Lys Ile Cys Lys Met Arg Pro Ser Ala Lys Ser Leu Val Cys Gly Lys
                 135                 140                 145

 cac tgg agt gac ggg gcc agc cag tgg ttc gcc tct ctg gtg agc ggc     1375
 His Trp Ser Asp Gly Ala Ser Gln Trp Phe Ala Ser Leu Val Ser Gly
             150                 155                 160

 tgc acc ctc ctt gtg aag gtc ttc tct gtg gtg cac agc gtc ctg cac     1423
 Cys Thr Leu Leu Val Lys Val Phe Ser Val Val His Ser Val Leu His
         165                 170                 175

 gtg gat gtg tac cag tac tca ggg gtc cag gat gcc atc aac ata aga     1471
 Val Asp Val Tyr Gln Tyr Ser Gly Val Gln Asp Ala Ile Asn Ile Arg
     180                 185                 190

 gac gtc ctc atc cag cag ggc tat gcc gag ctc acg gag gag tcc tac     1519
 Asp Val Leu Ile Gln Gln Gly Tyr Ala Glu Leu Thr Glu Glu Ser Tyr
 195                 200                 205                 210

 gag tcc aag caa agc cat gaa gtt ctc aag ggc ctc ttt tcc aag tca     1567
 Glu Ser Lys Gln Ser His Glu Val Leu Lys Gly Leu Phe Ser Lys Ser
                 215                 220                 225

 gta gaa aac atg aca gat ggc tct gtg ccc ttt ccc atg aaa gac gac     1615
 Val Glu Asn Met Thr Asp Gly Ser Val Pro Phe Pro Met Lys Asp Asp
             230                 235                 240

 gag aaa tat ctc atc cgg att ttg tta gag agc ttt tct acc aat aaa     1663
 Glu Lys Tyr Leu Ile Arg Ile Leu Leu Glu Ser Phe Ser Thr Asn Lys
         245                 250                 255

 ctg ggt act cca aac tgt aag gca gaa ctt cac ggg cct ttt aac cct     1711
 Leu Gly Thr Pro Asn Cys Lys Ala Glu Leu His Gly Pro Phe Asn Pro
     260                 265                 270

 tat gaa cta aag tgc cat agt ttg acc aga ata tcc aaa ttc agg tgt     1759
 Tyr Glu Leu Lys Cys His Ser Leu Thr Arg Ile Ser Lys Phe Arg Cys
 275                 280                 285                 290

 gtt tgg att gag aag gag agc atc aac tct gtc att atc agt gac gcc     1807
 Val Trp Ile Glu Lys Glu Ser Ile Asn Ser Val Ile Ile Ser Asp Ala
                 295                 300                 305

 cct gaa gac ctt cac cag aga atg ctg gtt gca gct tcc ctt tcc atc     1855
 Pro Glu Asp Leu His Gln Arg Met Leu Val Ala Ala Ser Leu Ser Ile
             310                 315                 320

 aat gcg act gga tct acg atg ctg ctg aga gaa acc tct ctg atg cct     1903
 Asn Ala Thr Gly Ser Thr Met Leu Leu Arg Glu Thr Ser Leu Met Pro
         325                 330                 335

 cat atc cct ggc ctc ccg gct ctc ctc agc atg tta ttc gca ccg gtg     1951
 His Ile Pro Gly Leu Pro Ala Leu Leu Ser Met Leu Phe Ala Pro Val
     340                 345                 350

 ata gag tta agg att gat cag aat ggc aag tac tat act gga gtc ctt     1999
 Ile Glu Leu Arg Ile Asp Gln Asn Gly Lys Tyr Tyr Thr Gly Val Leu
 355                 360                 365                 370

 tgt ggt ttg ggg tgg aat cca gct aca ggg gct tcc ata ctg ccc gag     2047
 Cys Gly Leu Gly Trp Asn Pro Ala Thr Gly Ala Ser Ile Leu Pro Glu
                 375                 380                 385

 cac gac atg gag ctt gcg ttt gac gtt caa ttc agc gtg gag gat gtc     2095
 His Asp Met Glu Leu Ala Phe Asp Val Gln Phe Ser Val Glu Asp Val
             390                 395                 400

 gtc gag gtt aat att ctc agg gct gct att aac aag cta gtc tgt gat     2143
 Val Glu Val Asn Ile Leu Arg Ala Ala Ile Asn Lys Leu Val Cys Asp
         405                 410                 415

 gga cca aat gga tgc aag tgt ctt ggg cca gag aga gtt gcg cag ctt     2191
 Gly Pro Asn Gly Cys Lys Cys Leu Gly Pro Glu Arg Val Ala Gln Leu
     420                 425                 430

 caa gac att gcc cgt cag aag ctt tta ggt ttg ttc tgt cag tca aaa     2239
 Gln Asp Ile Ala Arg Gln Lys Leu Leu Gly Leu Phe Cys Gln Ser Lys
 435                 440                 445                 450

 cca agg gag aag att gtt ccc aag tgg cat gaa aag ccc tac gag tgg     2287
 Pro Arg Glu Lys Ile Val Pro Lys Trp His Glu Lys Pro Tyr Glu Trp
                 455                 460                 465

 aat cag gtt gat cca aag ctg gtc atg gag cag gcc gac cgt gag agc     2335
 Asn Gln Val Asp Pro Lys Leu Val Met Glu Gln Ala Asp Arg Glu Ser
             470                 475                 480

 agc aga ggg aag aac acc ttt ctc tac cag ctc cac aaa ctg gtt gtg     2383
 Ser Arg Gly Lys Asn Thr Phe Leu Tyr Gln Leu His Lys Leu Val Val
         485                 490                 495

 ctc ggc acc tga gca tgtccacagg tggcctccag cacacccctc aggaagctgt     2438
 Leu Gly Thr 
     500

 ggaggctgga ttccaggctc cctccgcaga ctgactttcc tctgtgtctg ggtgttacag   2498

 tctgtgccca ctgcatccta aaggcctttt ctttcttctt ttctctttgg gtgatagtca   2558

 gagagtggtg tttttgttca ggtgggaagg attggaaact ctagtctttt ctagaaacag   2618

 aaaatcactg tattaaatat tttggaaaga ttgttctgaa agaagtctgt ttggataaag   2678

 agctgtattt tgctttaaat ttattaaggt aaatataagt agttaatctt agatgtaagg   2738

 ttccagaatg tgcttacata ttctgttctg ttacagtgat ttaaaccagt agtataggaa   2798

 aaaacttaaa aaacaaaaaa accatgtagt attttctgat ttttttttcc atgagggaaa   2858

 atatctaatt tttataagac taagttgagt tatacttctt ggttcacatt ttggaaatca   2918

 gagattacag attacatggc catagcttat ctgtgttaaa acaataaaag cattaaatga   2978

 aaaaaaaaaa aaa                                                      2991




      <210> 188
      <211> 2712
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(2377)

      <220>
      <221> misc_feature
      <222> (1)...(2712)
      <223> n = a,t,c or g

      <400> 188
 ctggccagtg ccaggcgccg gggtgcttca aggacatatc cctgggcagc cagtcacccc     60

 gcactgggtc ctggatggac aaccctggcg caccgtcagc ctggaggagc cggtctcgaa    120

 gccagac  atg ggg ctg gtg gcc ctg gag gct gaa ggc cag gag ctc ctg     169
          Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu
            1               5                  10

 ctt gag ctg gag aag aac cac agg ctg ctg gcc cca gga tac ata gaa      217
 Leu Glu Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu
  15                  20                  25                  30

 acc cac tac ggc cca gat ggg cag cca gtg gtg ctg gcc ccc aac cac      265
 Thr His Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His
                  35                  40                  45

 acg gat cat tgc cac tac caa ggg cga gta agg ggc ttc ccc gac tcc      313
 Thr Asp His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser
              50                  55                  60

 tgg gta gtc ctc tgc acc tgc tct ggg atg agt ggc ctg atc acc ctc      361
 Trp Val Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu
          65                  70                  75

 agc agg aat gcc agc tat tat ctg cgt ccc tgg cca ccc cgg ggc tcc      409
 Ser Arg Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser
      80                  85                  90

 aag gac ttc tca acc cac gag atc ttt cgg atg gag cag ctg ctc acc      457
 Lys Asp Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr
  95                 100                 105                 110

 tgg aaa gga acc tgt ggc cac agg gat cct ggg aac aaa gcg ggc atg      505
 Trp Lys Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met
                 115                 120                 125

 acc agc ctt cct ggt ggt ccc cag agc agg ggc agg cga gaa gcg cgc      553
 Thr Ser Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg
             130                 135                 140

 agg acc cgg aag tac ctg gaa ctg tac att gtg gca gac cac acc ctg      601
 Arg Thr Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu
         145                 150                 155

 ttc ttg act cgg cac cga aac ttg aac cac acc aaa cag cgt ctc ctg      649
 Phe Leu Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu
     160                 165                 170

 gaa gtc gcc aac tac gtg gac cag ctt ctc agg act ctg gac att cag      697
 Glu Val Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln
 175                 180                 185                 190

 gtg gcg ctg acc ggc ctg gag gtg tgg acc gag cgg gac cgc agc cgc      745
 Val Ala Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg
                 195                 200                 205

 gtc acg cag gac gcc aac gcc acg ctc tgg gcc ttc ctg cag tgg cgc      793
 Val Thr Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg
             210                 215                 220

 cgg ggg ctg tgg gcg cag cgg ccc cac gac tcc gcg cag ctg ctc acg      841
 Arg Gly Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr
         225                 230                 235

 ggc cgc gcc ttc cag ggc gcc aca gtg ggc ctg gcg ccc gtc gag ggc      889
 Gly Arg Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly
     240                 245                 250

 atg tgc cgc gcc gag agc tcg gga ggc gtg agc acg gac cac tcg gag      937
 Met Cys Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu
 255                 260                 265                 270

 ctc ccc atc ggc gcc gca gcc acc atg gcc cat gag atc ggc cac agc      985
 Leu Pro Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser
                 275                 280                 285

 ctc ggc ctc agc cac gac ccc gac ggc tgc tgc gtg gag gct gcg gcc     1033
 Leu Gly Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala
             290                 295                 300

 gag tcc gga ggc tgc gtc atg gct gcg gcc acc ggg cac ccg ttt ccg     1081
 Glu Ser Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro
         305                 310                 315

 cgc gtg ttc agc gcc tgc agc cgc cgc cag ctg cgc gcc ttc ttc cgc     1129
 Arg Val Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg
     320                 325                 330

 aag ggg ggc ggc gct tgc ctc tcc aat gcc ccg gac ccc gga ctc ccg     1177
 Lys Gly Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro
 335                 340                 345                 350

 gtg ccg ccg gcg ctc tgc ggg aac ggc ttc gtg gaa gcg ggc gag gag     1225
 Val Pro Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu
                 355                 360                 365

 tgt gac tgc ggc cct ggc cag gag tgc cgc gac ctc tgc tgc ttt gct     1273
 Cys Asp Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala
             370                 375                 380

 cac aac tgc tcg ctg cgc ccg ggg gcc cag tgc gcc cac ggg gac tgc     1321
 His Asn Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys
         385                 390                 395

 tgc gtg cgc tgc ctg ctg aag ccg gct gga gcg ctg tgc cgc cag gcc     1369
 Cys Val Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala
     400                 405                 410

 atg ggt gac tgt gac ctc cct gag ttt tgc acg ggc acc tcc tcc cac     1417
 Met Gly Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His
 415                 420                 425                 430

 tgt ccc cca gac gtt tac cta ctg gac ggc tca ccc tgt gcc agg ggc     1465
 Cys Pro Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly
                 435                 440                 445

 agt ggc tac tgc tgg gat ggc gca tgt ccc acg ctg gag cag cag tgc     1513
 Ser Gly Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys
             450                 455                 460

 cag cag ctc tgg ggg cct ggc tcc cac cca gct ccc gag gcc tgt ttc     1561
 Gln Gln Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe
         465                 470                 475

 cag gtg gtg aac tct gcg gga gat gct cat gga aac tgc ggc cag gac     1609
 Gln Val Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp
     480                 485                 490

 agc gag ggc cac ttc ctg ccc tgt gca ggg agg gat gcc ctg tgt ggg     1657
 Ser Glu Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly
 495                 500                 505                 510

 aag ctg cag tgc cag ggt gga aag ccc agc ctg ctc gca ccg cac atg     1705
 Lys Leu Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met
                 515                 520                 525

 gtg cca gtg gac tct acc gtt cac cta gat ggc cag gaa gtg act tgt     1753
 Val Pro Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys
             530                 535                 540

 cgg gga gcc ttg gca ctc ccc agt gcc cag ctg gac ctg ctt ggc ctg     1801
 Arg Gly Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu
         545                 550                 555

 ggc ctg gta gag cca ggc acc cag tgt gga cct aga atg gtg tgc cag     1849
 Gly Leu Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln
     560                 565                 570

 agc agg cgc tgc agg aag aat gcc ttc cag gag ctt cag cgc tgc ctg     1897
 Ser Arg Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu
 575                 580                 585                 590

 act gcc tgc cac agc cac ggg gtt tgc aat agc aac cat aac tgc cac     1945
 Thr Ala Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His
                 595                 600                 605

 tgt gct cca ggc tgg gct cca ccc ttc tgt gac aag cca ggc ttt ggt     1993
 Cys Ala Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly
             610                 615                 620

 ggc agc atg gac agt ggc cct gtg cag gct gaa aac cat gac acc ttc     2041
 Gly Ser Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe
         625                 630                 635

 ctg ctg gcc atg ctc ctc agc gtc ctg ctg cct ctg ctc cca ggg gcc     2089
 Leu Leu Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala
     640                 645                 650

 ggc ctg gcc tgg tgt tgc tac cga ctc cca gga gcc cat ctg cag cga     2137
 Gly Leu Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg
 655                 660                 665                 670

 tgc agc tgg ggc tgc aga agg gac cct gcg tgc agt ggc ccc aaa gat     2185
 Cys Ser Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp
                 675                 680                 685

 ggc cca cac agg gac cac ccc ctg ggc ggc gtt cac ccc atg gag ttg     2233
 Gly Pro His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu
             690                 695                 700

 ggc ccc aca gcc act gga cag ccc tgg ccc ctg gac cct gag aac tct     2281
 Gly Pro Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser
         705                 710                 715

 cat gag ccc agc agc cac cct gag aag cct ctg cca gca gtc tcg cct     2329
 His Glu Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro
     720                 725                 730

 gac ccc caa gca gat caa gtc cag atg cca aga tcc tgc ctc tgg tga     2377
 Asp Pro Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
 735                 740                 745

 gaggtagctc ctaaaatgaa cagatttaaa gacaggtggc cactgacagc cactccagga   2437

 acttgaactg caggggcaga gccagtgaat caccggacct ccagcacctg caggcagctt   2497

 ggaagtttct tccccgagtg gagcttcgac ccacccactc caggaaccca gagccacatt   2557

 agaagttcct gagggctgga gaacactgct gggcacactc tccagctcaa taaaccatca   2617

 gtcccagaag caaaggtccc acaggccctg acctccctca ccagcgnagg ctgccnagcg   2677

 ccggccatcc cccgcgggcg ccggcctcgc gagcc                              2712




      <210> 189
      <211> 2838
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1456)..(2838)

      <400> 189
 tgctgcccgc ctggcccact ccccaaacgc ctgctccccc tagtgtccag cagcctcctg     60

 gccactgtgc tcccagcccg gggcaatctc gtcctgcgga gacggctcat ttacattggg    120

 ccacgcttca tgatcgggcc ggggtccggg ctggtgtggc agctgctcgt ggggcaggca    180

 gctggggccg tgaggccacc gtcagaggct acgccaagcc tgtgtgctcc ctcctgcctc    240

 aggagcaggc ccccagcacc cagctgcccg gctgccatgc acaaacatta caaagtccac    300

 ttcgccaagg atgcccagag ccccaacggg cactacttct gggacccaga gttggggcac    360

 cgaaaaggat gctgtcatca gtggcgccag gactcagcgg ccctccgagc ccatgggccc    420

 tgtcggcctt ccccccaatc acactggcag ctggcctacc acagccacca agtgggtggc    480

 agtggctggc gccggggcct cctgccctcc gtcctgcagc agcagcggca gccccagtcc    540

 cagccctcac ctcccagccc cctgcggcag cggctctgcc ccattcacga agcccagaag    600

 gggctgcctg caacctccac tgtccccaag gaacctgcca gcgcccctca ggcgcccacc    660

 ttacccacca cggcaccagc catggccagg agtggcccag ctctaccctc cgcggctggc    720

 gtcctcctga agcccagcga gcccactgat gcccggcccc tgcccgcccc agcggcctgt    780

 ggctccttca ctgcctacag ctccgacatc ctgacagagg atgacgtcta ctgcagctgc    840

 ctggccaaga cactctgcca cgtgccggtc cctgtgaccg tgggtttcta tgcccctttc    900

 ggctgccgcc tgcacatgat gctggacaag atcacggcgc tgatgcagca ggaggccgcg    960

 cagcgcgaga gcgaggagct gcagcacgtg cagtggcggc cgcgtgccgt gagcggctgg   1020

 ggcgtcccgc agctactgtg gtacctggtg ttcctgcagc ccatcatcac cgaggtgcac   1080

 ctgcggcgca ggaacgcgca gttccttttc atccgcttta gcgcctggca gtacgcgggc   1140

 accgacaagc tgtgggccgg cctggtgacc acgttgtgcg agggcatccg ccgccactat   1200

 ggcgcactgc ccttcagcgt gtactcggtg ctgggcaaca agccggccac caggcaggac   1260

 tgctgccaga gcgagtggca ttgtcggcgc cgcgtgtgcc tggggctgct ggcgctgctg   1320

 gcggcgctgg gcctgggtgt ggggctgctc tacttgtcac tgggcggcca cgcgctgggc   1380

 cacggcagcc cgagcggcag cctgctcaag gtgtttggcg gcgcggccac cacactgtcg   1440

 ggctcggggc tgctc atg gcc gtg tac tcg gtg ggc aag cac ctg ttc gta    1491
                  Met Ala Val Tyr Ser Val Gly Lys His Leu Phe Val
                    1               5                  10

 agc cag cgc aag aag atc gag cgg ctg gtg tcg cgt gaa aag ttc ggc     1539
 Ser Gln Arg Lys Lys Ile Glu Arg Leu Val Ser Arg Glu Lys Phe Gly
          15                  20                  25

 agc cag ctg ggt ttc atg tgc gag gtg aag aag gag gtg gag ctg ctc     1587
 Ser Gln Leu Gly Phe Met Cys Glu Val Lys Lys Glu Val Glu Leu Leu
      30                  35                  40

 acc gac ttc ctg tgc ttc ctg gag atc tac cag cgg cgc agg ctg cgc     1635
 Thr Asp Phe Leu Cys Phe Leu Glu Ile Tyr Gln Arg Arg Arg Leu Arg
  45                  50                  55                  60

 gtg gtg ctg gag gtc acc ggg ctg gac acg tgc tac ccg gag cgc gtg     1683
 Val Val Leu Glu Val Thr Gly Leu Asp Thr Cys Tyr Pro Glu Arg Val
                  65                  70                  75

 gtg ggc gtg ctc aac gcc atc aac acg ctg ctg tcc gac agc cac gcg     1731
 Val Gly Val Leu Asn Ala Ile Asn Thr Leu Leu Ser Asp Ser His Ala
              80                  85                  90

 ccc ttc atc ttc atc ctg gtc gtg gac ccc agc atc ctg gcc gcg tgc     1779
 Pro Phe Ile Phe Ile Leu Val Val Asp Pro Ser Ile Leu Ala Ala Cys
          95                 100                 105

 cta gag agc gcg ggc aac atg aag ggc acg gcc gat aac ggc tac ctc     1827
 Leu Glu Ser Ala Gly Asn Met Lys Gly Thr Ala Asp Asn Gly Tyr Leu
     110                 115                 120

 ttc ctc aac cgc act gtc acg ctg ccc ttc tct gtg ccc att atg ggc     1875
 Phe Leu Asn Arg Thr Val Thr Leu Pro Phe Ser Val Pro Ile Met Gly
 125                 130                 135                 140

 cgc cgc acc aag ctg cag ttc ctg cac gat gcg gtg cag agc cgc gac     1923
 Arg Arg Thr Lys Leu Gln Phe Leu His Asp Ala Val Gln Ser Arg Asp
                 145                 150                 155

 gac ctg ttg tac cgc gag atg acg cgc aag ccg tgg ctg ccg ggg gac     1971
 Asp Leu Leu Tyr Arg Glu Met Thr Arg Lys Pro Trp Leu Pro Gly Asp
             160                 165                 170

 gcc ggg ggc gag agc gcg cag ctg ctg gcg gtg cag gcg cag gcg ggg     2019
 Ala Gly Gly Glu Ser Ala Gln Leu Leu Ala Val Gln Ala Gln Ala Gly
         175                 180                 185

 acg gag cgc ggg cag ggc cgc atc gac gac gag gcg gcg cgg cga atc     2067
 Thr Glu Arg Gly Gln Gly Arg Ile Asp Asp Glu Ala Ala Arg Arg Ile
     190                 195                 200

 cag gag gcg ctc ttc tgc ctt cac gac gag cgc gac tgc ctc tac gag     2115
 Gln Glu Ala Leu Phe Cys Leu His Asp Glu Arg Asp Cys Leu Tyr Glu
 205                 210                 215                 220

 tac gtg ccc gac aac gtg gtg tcc atg cgg cgc atc gtc aac acc gtg     2163
 Tyr Val Pro Asp Asn Val Val Ser Met Arg Arg Ile Val Asn Thr Val
                 225                 230                 235

 ccc atc acc gtg cgc ctg ctg cag cag cag cag cag cag ggg gac ttt     2211
 Pro Ile Thr Val Arg Leu Leu Gln Gln Gln Gln Gln Gln Gly Asp Phe
             240                 245                 250

 ggg ggc ccc acg ccg cgc cag gcg gtg gcg tgg gtg gtg ctc gcc aac     2259
 Gly Gly Pro Thr Pro Arg Gln Ala Val Ala Trp Val Val Leu Ala Asn
         255                 260                 265

 cag tgg ccg tgc cgc ctg agc tgg gcg ctg cag tgc ctg gag gac cgg     2307
 Gln Trp Pro Cys Arg Leu Ser Trp Ala Leu Gln Cys Leu Glu Asp Arg
     270                 275                 280

 cag cag acc ggg ggc gcg ccc gag ggc cgc gcg cgc ctc tgg gac gtt     2355
 Gln Gln Thr Gly Gly Ala Pro Glu Gly Arg Ala Arg Leu Trp Asp Val
 285                 290                 295                 300

 ttc cgc gac aac agc cgc gag ctg cac acc atg acc aag gcg ttg cag     2403
 Phe Arg Asp Asn Ser Arg Glu Leu His Thr Met Thr Lys Ala Leu Gln
                 305                 310                 315

 aac gtg ctc gac ctg gac ggc gac ccc gag ctc ttc gag cgc ttc ctg     2451
 Asn Val Leu Asp Leu Asp Gly Asp Pro Glu Leu Phe Glu Arg Phe Leu
             320                 325                 330

 ggc gcc gac ttc ccc ttc acc gtg gcc gag gcg cag agc ctg ctg cgc     2499
 Gly Ala Asp Phe Pro Phe Thr Val Ala Glu Ala Gln Ser Leu Leu Arg
         335                 340                 345

 tgc acg gtc aac ctg gac cac tcc atc cgc cgg cgc atg ggt ctc atc     2547
 Cys Thr Val Asn Leu Asp His Ser Ile Arg Arg Arg Met Gly Leu Ile
     350                 355                 360

 cga gcc gtc agc gcg ctc aag ccg ccc agc ccg ccc aag tcc cct acc     2595
 Arg Ala Val Ser Ala Leu Lys Pro Pro Ser Pro Pro Lys Ser Pro Thr
 365                 370                 375                 380

 cgc gat acc ccc cac gct gcc cac cgg gcc aac agc gcc tcc agg gcg     2643
 Arg Asp Thr Pro His Ala Ala His Arg Ala Asn Ser Ala Ser Arg Ala
                 385                 390                 395

 ccc ccg tcg ggc cgt gcc tca ggg caa gcc ggc gaa ggc cac cac act     2691
 Pro Pro Ser Gly Arg Ala Ser Gly Gln Ala Gly Glu Gly His His Thr
             400                 405                 410

 ggg gac ttg gcc cac agg ggc aag cta tgg ccg gtg gcc tgt gcg ctc     2739
 Gly Asp Leu Ala His Arg Gly Lys Leu Trp Pro Val Ala Cys Ala Leu
         415                 420                 425

 ttc cgt cca ggg caa tcc agc cca ggg tac ctg cct tac gag tca ctc     2787
 Phe Arg Pro Gly Gln Ser Ser Pro Gly Tyr Leu Pro Tyr Glu Ser Leu
     430                 435                 440

 cag ggc cac tgg tta gtc act gac act gaa gcc act gca tca gcc ccc     2835
 Gln Gly His Trp Leu Val Thr Asp Thr Glu Ala Thr Ala Ser Ala Pro
 445                 450                 455                 460

 tga                                                                 2838
 






      <210> 190
      <211> 3840
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (129)..(1532)

      <400> 190
 ctcctagagg ggcaggctcg gcgacaaggg gcgggggtgc cccgtcccag cgagggacgc     60

 ccggggctgg gggtgccggt cgagcccggg gcaacagctt caccaagttt ggcaaccgca    120

 acgtcttc atg aag gac aac agc tct tct tcc agc aca gac tcc cgc tcc     170
          Met Lys Asp Asn Ser Ser Ser Ser Ser Thr Asp Ser Arg Ser
            1               5                  10

 cgc tcc tcc tcc agg tcc ccg acg cgc cac ttc cgc aga agt gac tcc      218
 Arg Ser Ser Ser Arg Ser Pro Thr Arg His Phe Arg Arg Ser Asp Ser
  15                  20                  25                  30

 cac tca gac tcc gac agc tcc tac tca ggg aat gag tgt cac cct gtg      266
 His Ser Asp Ser Asp Ser Ser Tyr Ser Gly Asn Glu Cys His Pro Val
                  35                  40                  45

 ggc cgc agg aac ccg ccc cct aag ggc cgg ggc ggt cga ggg gcc cat      314
 Gly Arg Arg Asn Pro Pro Pro Lys Gly Arg Gly Gly Arg Gly Ala His
              50                  55                  60

 atg gat cgg ggc cga ggc agg gcg cag cgt ggg aag agg cac gat ctg      362
 Met Asp Arg Gly Arg Gly Arg Ala Gln Arg Gly Lys Arg His Asp Leu
          65                  70                  75

 gcg ccc acc aag cgc agt cga aag aag atg gcg gcg ctg gag tgt gag      410
 Ala Pro Thr Lys Arg Ser Arg Lys Lys Met Ala Ala Leu Glu Cys Glu
      80                  85                  90

 gac ccg gag cga gag ctg aag aag cag aag cgg gca gcc cgc ttc cag      458
 Asp Pro Glu Arg Glu Leu Lys Lys Gln Lys Arg Ala Ala Arg Phe Gln
  95                 100                 105                 110

 cac gga cac tcc cgc cgc ctg cgc ctc gag ccc ctg gtg ctg cag atg      506
 His Gly His Ser Arg Arg Leu Arg Leu Glu Pro Leu Val Leu Gln Met
                 115                 120                 125

 agc agc ctg gag agc agt ggg gct gac cct gac tgg cag gag ctg cag      554
 Ser Ser Leu Glu Ser Ser Gly Ala Asp Pro Asp Trp Gln Glu Leu Gln
             130                 135                 140

 atc gtg ggc acc tgc cct gac atc acc aag cac tac ctg cgc ctc acc      602
 Ile Val Gly Thr Cys Pro Asp Ile Thr Lys His Tyr Leu Arg Leu Thr
         145                 150                 155

 tgt gcc ccc gac ccg tcc acc gtg cgc cct gtg gca gtt ttg aaa aag      650
 Cys Ala Pro Asp Pro Ser Thr Val Arg Pro Val Ala Val Leu Lys Lys
     160                 165                 170

 tcg ctg tgc atg gtc aag tgc cac tgg aaa gag aag cag gac tac gcg      698
 Ser Leu Cys Met Val Lys Cys His Trp Lys Glu Lys Gln Asp Tyr Ala
 175                 180                 185                 190

 ttt gcc tgc gag cag atg aag tcg atc cgg cag gat ctg acg gtg cag      746
 Phe Ala Cys Glu Gln Met Lys Ser Ile Arg Gln Asp Leu Thr Val Gln
                 195                 200                 205

 ggc atc cgc acc gag ttc acg gtg gag gtg tac gag acc cat gcc cgg      794
 Gly Ile Arg Thr Glu Phe Thr Val Glu Val Tyr Glu Thr His Ala Arg
             210                 215                 220

 atc gcc ttg gag aag ggt gac cat gaa gag ttt aac cag tgc cag acg      842
 Ile Ala Leu Glu Lys Gly Asp His Glu Glu Phe Asn Gln Cys Gln Thr
         225                 230                 235

 cag ctc aag tcg ctg tac gcc gag aac ttg cct ggc aat gtg ggc gag      890
 Gln Leu Lys Ser Leu Tyr Ala Glu Asn Leu Pro Gly Asn Val Gly Glu
     240                 245                 250

 ttt act gcc tac cga atc ctc tac tac atc ttc acc aag aac tcg gga      938
 Phe Thr Ala Tyr Arg Ile Leu Tyr Tyr Ile Phe Thr Lys Asn Ser Gly
 255                 260                 265                 270

 gac atc acc acg gag ctg gca tac ctc aca cga gaa ctg aag gca gat      986
 Asp Ile Thr Thr Glu Leu Ala Tyr Leu Thr Arg Glu Leu Lys Ala Asp
                 275                 280                 285

 cct tgc gtg gcc cac gcc ttg gca tta agg aca gcc tgg gcc ctg ggc     1034
 Pro Cys Val Ala His Ala Leu Ala Leu Arg Thr Ala Trp Ala Leu Gly
             290                 295                 300

 aac tac cac cgc ttt ttc cgg ctc tac tgc cat gca ccc tgc atg tct     1082
 Asn Tyr His Arg Phe Phe Arg Leu Tyr Cys His Ala Pro Cys Met Ser
         305                 310                 315

 ggc tac ctc gtg gac aag ttt gca gat cgg gag cgc aag gtc gcc ctc     1130
 Gly Tyr Leu Val Asp Lys Phe Ala Asp Arg Glu Arg Lys Val Ala Leu
     320                 325                 330

 aag gcc atg atc aaa acg tat gtg gtg cca agc tcc ctt ctg cct ttg     1178
 Lys Ala Met Ile Lys Thr Tyr Val Val Pro Ser Ser Leu Leu Pro Leu
 335                 340                 345                 350

 ctc ttc cca tcc ttc cgc ctc gca ccg ccc ctc aga cca gct cct ggc     1226
 Leu Phe Pro Ser Phe Arg Leu Ala Pro Pro Leu Arg Pro Ala Pro Gly
                 355                 360                 365

 cgc agg cct ccc cca gcc ccc aac cct tgt cct ggt cct tgc ttc ccc     1274
 Arg Arg Pro Pro Pro Ala Pro Asn Pro Cys Pro Gly Pro Cys Phe Pro
             370                 375                 380

 atc atc ttt ctc cat tca gcc ctc ccc tct cca gtt cct ctt gct ctc     1322
 Ile Ile Phe Leu His Ser Ala Leu Pro Ser Pro Val Pro Leu Ala Leu
         385                 390                 395

 ctt gtt ggt cac ctc tgt gtt ccg ggt cac tcc tct ccc tct ccc cac     1370
 Leu Val Gly His Leu Cys Val Pro Gly His Ser Ser Pro Ser Pro His
     400                 405                 410

 tgt tcc cag ctc act gcc tct ggg gcc tct tct cca ccc cat ctg tgt     1418
 Cys Ser Gln Leu Thr Ala Ser Gly Ala Ser Ser Pro Pro His Leu Cys
 415                 420                 425                 430

 gtc tct tcc tcc tgt tct ctc ctg cct gga ccc cct agt tca ctc ctt     1466
 Val Ser Ser Ser Cys Ser Leu Leu Pro Gly Pro Pro Ser Ser Leu Leu
                 435                 440                 445

 gcc ctg ggc ttc ctc aga acc ctg agg tct ctg ctt tct cag ctt gtc     1514
 Ala Leu Gly Phe Leu Arg Thr Leu Arg Ser Leu Leu Ser Gln Leu Val
             450                 455                 460

 gct gtg ctc cca cca tag agacca tctagacagc ctctggtcta ccaggacaag     1568
 Ala Val Leu Pro Pro 
         465

 gcccagtccc actcagctcc tttgagagca ccagaaacgc ttagggagac acctgtgttg   1628

 aggccacact gggcgcggtg ccagaggccc ctggtcaggc catgcccctg cagtgtcctt   1688

 cgttcactag acattgcgcc tggcttgctg tgggtgggga tgagttgctt gactcatgtt   1748

 tagacgcatg gttctgtctg gtgattgagg tgcccaggcg acgctgggca atgtcaagag   1808

 aggttttcgc ttgtcacagc aaggggatgc tcttggcatc tagtgagtgg aggcaggatg   1868

 ctgcctgcca ctgccattgg gcctcagagc tcagtcttgc caaggtggag aaattctggt   1928

 cgaagaggtt gaccggtaga ctgaagaggc cttgagagcc ctggccaggt ggctgtccac   1988

 gtgaggtcat agtcacagca tggaggcctt gagagcctgg ccaggtggcc ctccacgtga   2048

 ggtcatggtc acagcatggg ggccttgagt gcctggccag gtggccctcc acgtgaggtc   2108

 atggtcacag catggaggcc ttgagagcct ggccaggtgg ccctccatgt gaggttgtgg   2168

 tcacagcatg ggggccttga gagcctggcc aggtggccct ccacgtgagg tcatggtcac   2228

 agcatggagg ccttgagagc ctggccaggt ggccctccgt gtgaggtcat ggtcacagca   2288

 tagtttggag ctagggaggg actgtcagcc tggaggtttg gagactcatt ctggaatcta   2348

 gtgtgggtca agccaacttc agggagaggc tgagccaggg taggagtcac aggagcagac   2408

 gaggatgtgg ggtgccgtgc acagagctcc atgaccagct tgggaagtta gaaggaaggg   2468

 gaggcaggag gctgcttagt ctgctgccat gatgggcccc atgaatggtg gctctcaagc   2528

 ttctgtgcta cacaggggtg tgtggttggg cgagtgtcct tgttaattga tacctaattg   2588

 gccttggttg ggaacatagc catgagtgcc cctcgtgggt ggggcgccag tctgtcattg   2648

 acctcattgt gtcagcacct tccccccaag gaggctgacc ctgccctgcc agctgagact   2708

 gggagacgga gtgggctctg atcccagggc ttccaggaaa gctctggctt tggagcagaa   2768

 gcgggttcta ggacttagtg cccctcactc ggtgcctggg ttcctgtgtg tgtggaaagg   2828

 gtagggctgc accctgtgga agagggttca gggagctctg aggacctggc tcgtgctaga   2888

 tgctcagtca gtagtgtgtt ttagcagcag ccggaagtga ctgctttcag tgtgtagtgg   2948

 tgagtgctag ctggcacccc tgcgcctggc ttcccagaca ctgtaacgca gggcagggga   3008

 ggcagcgagg gctgggtccc cacggtggcc ctggcatgcc ccgacatcac ccatcccctg   3068

 acactgtgct gctccctcca tcatggatcc ctgaccctca gcacagctgg agagagaccc   3128

 gctgggcacc ttaccctgaa ccgtacgaca gatcaatcaa atgaaacaca tgcagcagag   3188

 ataagatgag atgatagaaa ggagagcaca agtgagacta gagagacaat aaaacaacaa   3248

 aaatgtagca aaaaaaaaga aggagagaag aaggtgatac taagataatg aaagagagcg   3308

 aagagagagt aaccggaggg aattagtgag tgtagatagg caagaaattg aataagaaaa   3368

 tagagtaaaa gatgtatgag agaaaacgca gaaaaatcga gaaatgataa tacaaagaag   3428

 aataagatag atagaaatga taagagtaga tagtaaaata gaggaataag aaaattaaga   3488

 taagaataaa ataagagatg atagaagagt acttgagaat acgattaagg catcgagacg   3548

 gggggaacgt gggggagcct aagacgaaga acagtagacg agcgagaaga aagagagggg   3608

 aaacgagcaa gagcagggag cgggagggac tgcgataacg aagagaagag aggagcggcg   3668

 gaggagacag cgcgaggagg gggtctcgag ggcacaagag gactgaaggc gacggcgagt   3728

 atacagaaga gagagcgaaa tgagagtgac gagacgtcta cgatgacgca agagaaatag   3788

 agagggagca ggagagacag aaggcaatag cagagaggag gaggagagag gg           3840




      <210> 191
      <211> 2392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (978)..(1244)

      <400> 191
 aggatacaaa ttattgtcaa ataaaaactc gtaaagcata cggtattcac acagagatgc     60

 aggacaatac ccgatgcagt aagaaaggcc cagcgggctg agaagtggct cctgtttgtt    120

 ttgaaaattg cgcatgcttg ccaaccacgc cctgtccaca ccacactgcg catgctcgcc    180

 ggcccccgcc ccgcgcacgg cgtcagcgtc tagacgcagg tgcgttcccg tcgaggctcg    240

 cgcagcgggc gtttttgggg atcgcctggc gggggtgttc gggagccgcg ggctgaagca    300

 cgggggcgtg caggcgccca ggcctcgtgt agtgagggcc gagccccgcg ccggcttcgc    360

 tgtagtccgc agcccccggc ggctttgtgg gcgcagccac gctcctcagc cgcccgccca    420

 cctgggcctg ggccccggtt gtttccctgc ggtggctgtg gtcgttcccg ttccagggtc    480

 tcgagcgcac cgccccttcg ctgcgctgtt agtcgagggc agttttctgg gggatccccc    540

 gatccccccg cgccgctcag gcgtcttggc tcgcggaagc gcaggcgccg actgcctggc    600

 gtcgtccgtg actcctggcc cttctctgtg gatccctttg cttctcgttg cgggttgtgt    660

 ttcctgcttc gtgggcctgg ccgtttgcgt ttggatgcag gcccgggtga gccctgcgtg    720

 gcccgctggc cttttcctgc tccctaggtg actgagccgc gtgtgtgaca catcggagtg    780

 aattgaggca acgcgttcct ttccaggctt gcagcgggcg gtgtcgttca cgctcctgag    840

 cagagccttc cggtgcttta ctcgacgcca caaatagtgc agggttcctc ccaggggctg    900

 tcgcgagcta gaactcttcc ccgcccctgt gagctcgggc tgttcttcct cctccgcgtg    960

 gctcactcca gcctcgg   atg ttt cct cgc tgc aca gac ctg ctc ggg aag    1010
                      Met Phe Pro Arg Cys Thr Asp Leu Leu Gly Lys
                        1               5                  10

 act cga gaa ggc cac ccc agg act cca gct ctc ccc gga agg gct tcc     1058
 Thr Arg Glu Gly His Pro Arg Thr Pro Ala Leu Pro Gly Arg Ala Ser
              15                  20                  25

 cct cgg att gcg tct tgg ccc ctg gaa ccc tcc ctc tgt atc ctc tgc     1106
 Pro Arg Ile Ala Ser Trp Pro Leu Glu Pro Ser Leu Cys Ile Leu Cys
          30                  35                  40

 tgt tcc tct ctt ggc ctc cat ttg ggt tgt ggc ctg gat act ctg gct     1154
 Cys Ser Ser Leu Gly Leu His Leu Gly Cys Gly Leu Asp Thr Leu Ala
      45                  50                  55

 cgc tgc ttc cct tct ctt aag gat cac agc cct gca ctg cct gtc gtc     1202
 Arg Cys Phe Pro Ser Leu Lys Asp His Ser Pro Ala Leu Pro Val Val
  60                  65                  70                  75

 cgg tgc ctg gaa acc att gta ttt ttt ggt ctg att ttg tag ttgtttg     1251
 Arg Cys Leu Glu Thr Ile Val Phe Phe Gly Leu Ile Leu 
                  80                  85

 agaacttaag tctggtccct cacactccat gcccagaagc agaaatgagt aaagtttgtt   1311

 ttatcttttc ttaatatgac aattattgtg ttggttcaac ttatgttgta ctttaattag   1371

 aagaaatttg gccgaaaata caaggaaaat atacaaatgc aagtaatttt ttttaaactt   1431

 ccctgaaagc agggtctaaa gaaattacca accaacttag actggatcta gaagaaaagg   1491

 aagggtcttt gcagtcttag gactcttccg ttccgcgacg taggtgttag gataacagcc   1551

 ataaatggtt gtaagacttt gggctcagat aagtagactt aagttcaaat tttgacttat   1611

 tttacaagtg tgtgattttt ggcaagctca tcttcctaaa ccatgagctc cttatttgta   1671

 aaggggacat tagccactct ccagcaacag ccctggtact tcttcagtcc tgggatggga   1731

 cgtatgatta gcctaagcga accagaaaat ccaggcccgt gaccagtgac ttgatcaggg   1791

 ctggcgatat atctaggtag gccaaccagg tggactcagt atttttgtgg gtgctactgg   1851

 aaaatttatt taattctaac tgaatgtaga aacagcaaca gacatgaaat ggcagttgta   1911

 ttgctgtctt atcatgaggt gagggcctga agctatggta gccaccctgt gaaccttgga   1971

 aggagggttc tacaggaact ggcagagctg agactgggac gcaacccatg tcctggtgac   2031

 gtatttgagt cctgaggctg gccctcctgt tagtcttttc tcttactggc ttcagccaga   2091

 tggggtctgg ttttctgtta cttgcaacag gaaaaattgg aatgatatct atgcatgcta   2151

 ttaccgcctt atggctgtgg tgagattaaa acatgatact gtgggtgaac tgcttagtac   2211

 agtgcctgct attctttatg ttggttttaa ggtatttttc ttgaacttta aagttctaag   2271

 aaaaattacc gttttaaaat tcctaccctc tgttcacatg tttaaatttt catgatagtt   2331

 tttctgtctg catgttttct attcaaaata aattggtcat tcttcagtta aaaaaaaaaa   2391

 a                                                                   2392




      <210> 192
      <211> 2695
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (533)..(2287)

      <400> 192
 gcccaaggag gaggacggag gctgccagaa gtccctgtat ctggagacac tgcacgccct     60

 tgaggatctg ctgacgagcc tcctgcagcg gaacatgacc ccccaaggcc tgcagatcat    120

 gattgagcac ctgagcccat ggatcaagtc cccaagaggt cacgagcggg cgcgggccct    180

 gggcctgagc gccctcctgc tgcgctactt cctggagcac ctgcgtgtca gcgccctggt    240

 gcccttccac aacctgggcc ttctcatcgg cctcttctcc ccacggtgtg cggacctgtg    300

 gcctgccacc cgccaggagg ccgtggactg tgtctactcc ctgctgtacc tccagctcgg    360

 ctatgagggc ttctcccggg actaccgcga tgacgtggcg gagcggctcc tcagcctcaa    420

 ggacggcctc gtgcaccctg accccgccat tctcttccac acctgccaca gtgtaggcca    480

 gattattgcc aagcgcctcc ccccagacca gctcatcagc ctcttgctaa cc    atg     535
                                                              Met
                                                                1

 ttt gag gcc ctg gga gac ccc gaa aag aac tgc tcc cga gca gct acc      583
 Phe Glu Ala Leu Gly Asp Pro Glu Lys Asn Cys Ser Arg Ala Ala Thr
               5                  10                  15

 gtc atg atc aac tgc ctg ctg cag gag cgg ggc ggt gtg ctc cag gag      631
 Val Met Ile Asn Cys Leu Leu Gln Glu Arg Gly Gly Val Leu Gln Glu
          20                  25                  30

 aag gtg ccc gag atc gtg agc gtc ctg cgc tcc aag ctt cag gag gcc      679
 Lys Val Pro Glu Ile Val Ser Val Leu Arg Ser Lys Leu Gln Glu Ala
      35                  40                  45

 cag gga gag cac gtc ctg ccg gcc gcc cag cac agc gtg tac ctc ctg      727
 Gln Gly Glu His Val Leu Pro Ala Ala Gln His Ser Val Tyr Leu Leu
  50                  55                  60                  65

 gcc acc cag cac tgc gca gcc gtg gtg tcc agc ctc ctg ggc agc ccc      775
 Ala Thr Gln His Cys Ala Ala Val Val Ser Ser Leu Leu Gly Ser Pro
                  70                  75                  80

 ttg ccc ttg gac agc cac acc tgc atg ctg tgg cgg gcg ctg gcg gtg      823
 Leu Pro Leu Asp Ser His Thr Cys Met Leu Trp Arg Ala Leu Ala Val
              85                  90                  95

 gag cct cgc cta gct gcc cag gtc ctg ggg ctg ctg ctg gag aag atg      871
 Glu Pro Arg Leu Ala Ala Gln Val Leu Gly Leu Leu Leu Glu Lys Met
         100                 105                 110

 agt agg gac gtc cct ttc aag gag agc cgg gcc ttc ctg ctg ggc cgc      919
 Ser Arg Asp Val Pro Phe Lys Glu Ser Arg Ala Phe Leu Leu Gly Arg
     115                 120                 125

 acc cca gac cgc gtg gcc acg ctg ctg cct ctc tcg gct acc tgt gca      967
 Thr Pro Asp Arg Val Ala Thr Leu Leu Pro Leu Ser Ala Thr Cys Ala
 130                 135                 140                 145

 ctg ttt gag gtc atg tcc acg cct gca gcg ggg ccc gcg gtg ctc gag     1015
 Leu Phe Glu Val Met Ser Thr Pro Ala Ala Gly Pro Ala Val Leu Glu
                 150                 155                 160

 ctc tac ccc cag ctg ttt gtg gtg ctt ctg ctg cgc gtc agc tgc acc     1063
 Leu Tyr Pro Gln Leu Phe Val Val Leu Leu Leu Arg Val Ser Cys Thr
             165                 170                 175

 gtg ggt gtc cag ctg ccc cgg aac ctg cag gcc cag gaa agg agg ggt     1111
 Val Gly Val Gln Leu Pro Arg Asn Leu Gln Ala Gln Glu Arg Arg Gly
         180                 185                 190

 gcc agt cca gcc cta gcc acc agg aac ctg gaa ccc tgc agc tct gca     1159
 Ala Ser Pro Ala Leu Ala Thr Arg Asn Leu Glu Pro Cys Ser Ser Ala
     195                 200                 205

 gtg gac acc ctg cgg tcc atg cta ctc cgc agc ggc agc gag gat gtg     1207
 Val Asp Thr Leu Arg Ser Met Leu Leu Arg Ser Gly Ser Glu Asp Val
 210                 215                 220                 225

 gta cag cgc atg gac ctg gag gga ggc tgg gaa ctg ctc agg acc tcg     1255
 Val Gln Arg Met Asp Leu Glu Gly Gly Trp Glu Leu Leu Arg Thr Ser
                 230                 235                 240

 gcg ggg cat gag gag ggg gcc acc agg ttg gcc agg gcc atg gct gag     1303
 Ala Gly His Glu Glu Gly Ala Thr Arg Leu Ala Arg Ala Met Ala Glu
             245                 250                 255

 cac gca ggg ccc cga ctc ccc ctg gtg ctg aag acg ctg gca tgc aca     1351
 His Ala Gly Pro Arg Leu Pro Leu Val Leu Lys Thr Leu Ala Cys Thr
         260                 265                 270

 cac agc agt gcg tat gag aac cag agg gtg acc acc acc gcc ttc ctg     1399
 His Ser Ser Ala Tyr Glu Asn Gln Arg Val Thr Thr Thr Ala Phe Leu
     275                 280                 285

 gcc gag ctg ctg aac agc aac gtg gcc aac gac ctc atg ctc ttg gac     1447
 Ala Glu Leu Leu Asn Ser Asn Val Ala Asn Asp Leu Met Leu Leu Asp
 290                 295                 300                 305

 tcg ctg ctg gag agc ctg gcg gct cgc cag aag gac aca tgc gcc agc     1495
 Ser Leu Leu Glu Ser Leu Ala Ala Arg Gln Lys Asp Thr Cys Ala Ser
                 310                 315                 320

 gtg cgg agg ctg gtg ctc cgc ggc ctg gcc aac ctg gcc tcc ggc tgc     1543
 Val Arg Arg Leu Val Leu Arg Gly Leu Ala Asn Leu Ala Ser Gly Cys
             325                 330                 335

 cct gac aag gtg cga acc cac ggc ccc cag ctc ctc aca gcc atg att     1591
 Pro Asp Lys Val Arg Thr His Gly Pro Gln Leu Leu Thr Ala Met Ile
         340                 345                 350

 ggc ggg ctg gac gac ggg gac aac cct cac agc cca gtg gcc ctg gag     1639
 Gly Gly Leu Asp Asp Gly Asp Asn Pro His Ser Pro Val Ala Leu Glu
     355                 360                 365

 gcc atg ctg ggc ctt gcg agg ctg gtg cac ctg gtg gag tcc tgg gac     1687
 Ala Met Leu Gly Leu Ala Arg Leu Val His Leu Val Glu Ser Trp Asp
 370                 375                 380                 385

 ctg cgc tca ggg ctg ctg cac gtg gcc atc cgc atc cgg cct ttc ttc     1735
 Leu Arg Ser Gly Leu Leu His Val Ala Ile Arg Ile Arg Pro Phe Phe
                 390                 395                 400

 gac agt gag aag atg gag ttc cgg acg gca tct atc cgc ctc ttt ggg     1783
 Asp Ser Glu Lys Met Glu Phe Arg Thr Ala Ser Ile Arg Leu Phe Gly
             405                 410                 415

 cac ctt aac aag gtc tgc cac gga gac tgt gag gac gtc ttc ctg gac     1831
 His Leu Asn Lys Val Cys His Gly Asp Cys Glu Asp Val Phe Leu Asp
         420                 425                 430

 cag gtg gtg ggc ggg ctg gcg ccc ctg ctg ctg cac ctg cag gac cct     1879
 Gln Val Val Gly Gly Leu Ala Pro Leu Leu Leu His Leu Gln Asp Pro
     435                 440                 445

 cag gcc act gtg gcc agc gcc tgc agg ttt gcc ctg cgc atg tgt ggc     1927
 Gln Ala Thr Val Ala Ser Ala Cys Arg Phe Ala Leu Arg Met Cys Gly
 450                 455                 460                 465

 ccc aat ctg gca tgt gag gag ctc tca gct gct ttc cag aaa cac ctg     1975
 Pro Asn Leu Ala Cys Glu Glu Leu Ser Ala Ala Phe Gln Lys His Leu
                 470                 475                 480

 cag gag ggc cga gcc ctg cac ttc ggg gag ttc ctc aac acc acc tgc     2023
 Gln Glu Gly Arg Ala Leu His Phe Gly Glu Phe Leu Asn Thr Thr Cys
             485                 490                 495

 aag cac ctg atg cac cat ttc cca gac ctg ctg ggc cgt ctc ctg acc     2071
 Lys His Leu Met His His Phe Pro Asp Leu Leu Gly Arg Leu Leu Thr
         500                 505                 510

 acc tgc ctg ttc tac ttc aag agc agc tgg gag aac gtc cga gct gct     2119
 Thr Cys Leu Phe Tyr Phe Lys Ser Ser Trp Glu Asn Val Arg Ala Ala
     515                 520                 525

 gca ccc ctg ttc acc ggg ttc ctg gtg ctg cac tcg gag ccc agg cag     2167
 Ala Pro Leu Phe Thr Gly Phe Leu Val Leu His Ser Glu Pro Arg Gln
 530                 535                 540                 545

 cag ccg cag gtg gac ctg gac cag ctc att gcg gcg ctc cag atc ctg     2215
 Gln Pro Gln Val Asp Leu Asp Gln Leu Ile Ala Ala Leu Gln Ile Leu
                 550                 555                 560

 ctg aag gac ccg gcc ccc gag gtg cgg acg agg gct gct gag gcc ctg     2263
 Leu Lys Asp Pro Ala Pro Glu Val Arg Thr Arg Ala Ala Glu Ala Leu
             565                 570                 575

 ggc cgc ctg gtg aag ctc gcc taa ggctccggcc agcaccccca gcgaggagta    2317
 Gly Arg Leu Val Lys Leu Ala 
         580

 tgcacccaga cctgtgcctg agctccaaga cagggcctcc tgaggaccac agcctgggca   2377

 cacgactgga ggggcctggc cccagaacag gcactgctgg ggaccaaacc caagcccttc   2437

 agtgagggat gtgcccaata aactcatctg ctcccagcga gtgactgaca gggtgcgatg   2497

 ccgagcctct taggggatgg gccagagggt gccctggact ggctgtgttg tccccactgt   2557

 ttttgcaaaa ttgagtgagg ggaaggctcg gcgctgtggt gtgggcggct ttgttggcaa   2617

 cccctactca agaaggtggg agcaccagct agcacagggt aaagtactct tagttcagca   2677

 caactcttct catagcat                                                 2695




      <210> 193
      <211> 1942
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (803)..(1855)

      <220>
      <221> misc_feature
      <222> (1)...(1942)
      <223> n = a,t,c or g

      <400> 193
 gggcctggct ggggtgctca gcccaatttt ccgtgtaggg agcgggcggc ggcgggggag     60

 gcagaggcgg aggcggagtc aagagcgcac cgccgcgccc gccgtgccgg gcctgagctg    120

 gagccgggcg tgagtcgcag caggagccgc agccggagtc acagccgcag ccagagccgc    180

 agccaaagcc tcagagagca ggagttggag cgcaggccct gctggatccg cgcctagctc    240

 gccgccaggc accggccgga ggacggggcc gtggtgtcag ctcactgccc gggcgctgtg    300

 ggaggcagcg agcccgcgac cccccgggcc gggcaccgcc aggcgcggag cccagatcgc    360

 ccccctgcca ggcctggtca cggccagagc acgcaggagt tcccagggtc tggatctgcg    420

 cgcaccctaa tgacctgggg actgaagaga aaaaaggaac gaggatttca tctaaaagca    480

 taacgtgggc actaggcgag gaggaaagtg gagaccacct ggcacggggc agaggtgcct    540

 ggagcccacg cttgagcatc ggagaccctg gcatcctagc agccgcgacc ttggctctgc    600

 cctgtctgag ctggaaacac agcttagctt ctagacatcg ctggcacagg cctggcacaa    660

 gttagcagtg ttctcacctg tctgaaacgg gacacggggt cggaggaacc aggatctagc    720

 cttggcccca agcggaactc tctggtggcc cagaggtcgt cactggggga gcccgcctcc    780

 ngccctagcc tcactggtgc gg atg tgc cgc tgc ccg ccg gag cac cat gat     832
                          Met Cys Arg Cys Pro Pro Glu His His Asp
                            1               5                  10

 ggc agg atg acc tca gcc gaa gta gga gca gca gct ggt ggt gct cag      880
 Gly Arg Met Thr Ser Ala Glu Val Gly Ala Ala Ala Gly Gly Ala Gln
                  15                  20                  25

 gcg gct ggg ccc ccc gag tgg ccc cct ggc agc cct cag gcc ctc cgg      928
 Ala Ala Gly Pro Pro Glu Trp Pro Pro Gly Ser Pro Gln Ala Leu Arg
              30                  35                  40

 cag cct ggc cgg gcc cga gtg gcc atg gca gca ctg gtg tgg ctg ctg      976
 Gln Pro Gly Arg Ala Arg Val Ala Met Ala Ala Leu Val Trp Leu Leu
          45                  50                  55

 gcg gga gcc agc atg tca agc ctc aac aag tgg atc ttc aca gtg cac     1024
 Ala Gly Ala Ser Met Ser Ser Leu Asn Lys Trp Ile Phe Thr Val His
      60                  65                  70

 ggc ttt ggg cgg ccc ctg ctg ctg tcg gcc ctg cac atg ctg gtg gca     1072
 Gly Phe Gly Arg Pro Leu Leu Leu Ser Ala Leu His Met Leu Val Ala
  75                  80                  85                  90

 gcc ctg gca tgc cac cgg ggg gca cgg cgc ccc atg cca ggc ggc act     1120
 Ala Leu Ala Cys His Arg Gly Ala Arg Arg Pro Met Pro Gly Gly Thr
                  95                 100                 105

 cgc tgc cga gtc cta ctg ctc agt ctc acc ttt ggc acg tcc atg gcc     1168
 Arg Cys Arg Val Leu Leu Leu Ser Leu Thr Phe Gly Thr Ser Met Ala
             110                 115                 120

 tgc ggc aac gtg ggc cta agg gct gtg ccc ctg gac ctg gca caa ctg     1216
 Cys Gly Asn Val Gly Leu Arg Ala Val Pro Leu Asp Leu Ala Gln Leu
         125                 130                 135

 gtt act acc acc aca cct ctg ttc acc ctg gcc ctg tcg gcg ctg ctg     1264
 Val Thr Thr Thr Thr Pro Leu Phe Thr Leu Ala Leu Ser Ala Leu Leu
     140                 145                 150

 ctg ggc cgc cgc cac cac cca ctt cag ttg gcc gcc atg ggt ccg ctc     1312
 Leu Gly Arg Arg His His Pro Leu Gln Leu Ala Ala Met Gly Pro Leu
 155                 160                 165                 170

 tgc ctg ggg gcc gcc tgc agc ctg gct gga gag ttc cgg aca ccc cct     1360
 Cys Leu Gly Ala Ala Cys Ser Leu Ala Gly Glu Phe Arg Thr Pro Pro
                 175                 180                 185

 acc ggc tgt ggc ttc ctg ctc gca gcc acc tgc ctc cgc gga ctc aag     1408
 Thr Gly Cys Gly Phe Leu Leu Ala Ala Thr Cys Leu Arg Gly Leu Lys
             190                 195                 200

 tcg gtt cag caa agt gcc ctg ctg cag gag gag agg ctg gac gcg gtg     1456
 Ser Val Gln Gln Ser Ala Leu Leu Gln Glu Glu Arg Leu Asp Ala Val
         205                 210                 215

 acc ctg ctt tac gcc acc tcg ctg ccc agc ttc tgc ctg ctg gcg ggt     1504
 Thr Leu Leu Tyr Ala Thr Ser Leu Pro Ser Phe Cys Leu Leu Ala Gly
     220                 225                 230

 gca gcc ctg gtg ctg gag gct ggc gtt gcc cca ccg ccc act gct ggc     1552
 Ala Ala Leu Val Leu Glu Ala Gly Val Ala Pro Pro Pro Thr Ala Gly
 235                 240                 245                 250

 gac tct cgc ctc tgg gcc tgc atc ctg ctc agc tgc ctc ctg tct gtt     1600
 Asp Ser Arg Leu Trp Ala Cys Ile Leu Leu Ser Cys Leu Leu Ser Val
                 255                 260                 265

 ctc tat aac ctg gcc agc ttc tcc ctg ctg gcc ctc acc tct gcc ctc     1648
 Leu Tyr Asn Leu Ala Ser Phe Ser Leu Leu Ala Leu Thr Ser Ala Leu
             270                 275                 280

 acc gtc cac gtc ctg ggc aac ctc acc gtg gtg ggc aac ctc atc ctg     1696
 Thr Val His Val Leu Gly Asn Leu Thr Val Val Gly Asn Leu Ile Leu
         285                 290                 295

 tcc cgg ctg ttg ttt ggc agc cgc ctc agt gcc ctc agc tac gtg ggc     1744
 Ser Arg Leu Leu Phe Gly Ser Arg Leu Ser Ala Leu Ser Tyr Val Gly
     300                 305                 310

 atc gca ctc act ctt tca gga atg ttc ctt tac cac aac tgc gag ttc     1792
 Ile Ala Leu Thr Leu Ser Gly Met Phe Leu Tyr His Asn Cys Glu Phe
 315                 320                 325                 330

 gtg gcc tcc tgg gct gcc cgt cgg ggg ctg tgg cgg agg gac cag ccc     1840
 Val Ala Ser Trp Ala Ala Arg Arg Gly Leu Trp Arg Arg Asp Gln Pro
                 335                 340                 345

 agc aag ggt ctt tga gacctggggg atctcaggag ccacctggga tggccctggc     1895
 Ser Lys Gly Leu 
             350

 ctgaatccag cctccgctgt ggccatagaa ggaatggaga acaggga                 1942




      <210> 194
      <211> 2134
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1992)

      <400> 194
  atg gca gta tcc aca gaa act gca gac tgg tta ggg cct tgt aat tct      48
  Met Ala Val Ser Thr Glu Thr Ala Asp Trp Leu Gly Pro Cys Asn Ser
    1               5                  10                  15

 gcg cag ctg gaa cgc aag att tgg ggg aag gcc cgg ctc cct gcc caa       96
 Ala Gln Leu Glu Arg Lys Ile Trp Gly Lys Ala Arg Leu Pro Ala Gln
              20                  25                  30

 agg cgg ctg tgc gct aag tgg cag acg ctc ggg gag agc cgg cgc ggg      144
 Arg Arg Leu Cys Ala Lys Trp Gln Thr Leu Gly Glu Ser Arg Arg Gly
          35                  40                  45

 gcg gac ccc agc gcc agt agt gac agg ggc gaa cgc cgc cgg gag act      192
 Ala Asp Pro Ser Ala Ser Ser Asp Arg Gly Glu Arg Arg Arg Glu Thr
      50                  55                  60

 cca gcc ggc ggg cga gca ggt cca tgg ctg gtg cag acg gca gct ggg      240
 Pro Ala Gly Gly Arg Ala Gly Pro Trp Leu Val Gln Thr Ala Ala Gly
  65                  70                  75                  80

 aag cac cga ggg gac acc cac cta gag cgg gct cca ggc cgg cac ttc      288
 Lys His Arg Gly Asp Thr His Leu Glu Arg Ala Pro Gly Arg His Phe
                  85                  90                  95

 cgc ttc cgc ccg tcc ggg tca cgt ggc gag gcc gcc gcc gcg gcc atc      336
 Arg Phe Arg Pro Ser Gly Ser Arg Gly Glu Ala Ala Ala Ala Ala Ile
             100                 105                 110

 acc act gtg ggc agc ctc act tgg ctg ccg ccc cga gac ccc agc ccg      384
 Thr Thr Val Gly Ser Leu Thr Trp Leu Pro Pro Arg Asp Pro Ser Pro
         115                 120                 125

 tac ctg ggc ttc gcg ccc gcc aag tgg gcc cag ccc tgg ctc ctg cgc      432
 Tyr Leu Gly Phe Ala Pro Ala Lys Trp Ala Gln Pro Trp Leu Leu Arg
     130                 135                 140

 cct gtg gcg gcc acc tcc atc gcc ttg ctt tcc ctt cgg gca ctg ggg      480
 Pro Val Ala Ala Thr Ser Ile Ala Leu Leu Ser Leu Arg Ala Leu Gly
 145                 150                 155                 160

 gtc gct cag ggc ggg aca tgg gtg aac gga agt gga agc tca ttg agc      528
 Val Ala Gln Gly Gly Thr Trp Val Asn Gly Ser Gly Ser Ser Leu Ser
                 165                 170                 175

 agc ccc gga ggg gct agc cct gag gct gac ctg ccc aga gtc ccc acc      576
 Ser Pro Gly Gly Ala Ser Pro Glu Ala Asp Leu Pro Arg Val Pro Thr
             180                 185                 190

 atc gcg ctg ctt agt ggc ctc tcc ctg cag cct gtc gtt gct ggt ggc      624
 Ile Ala Leu Leu Ser Gly Leu Ser Leu Gln Pro Val Val Ala Gly Gly
         195                 200                 205

 ggc atg gtc ttc tgt ctg tcg agc gag gag ccg cgc cgc ccg ctg cga      672
 Gly Met Val Phe Cys Leu Ser Ser Glu Glu Pro Arg Arg Pro Leu Arg
     210                 215                 220

 agc gac atg gtc cac ttc cag gcc tcg gaa gtc cag cag ctg cta cac      720
 Ser Asp Met Val His Phe Gln Ala Ser Glu Val Gln Gln Leu Leu His
 225                 230                 235                 240

 aac aag ttc gtg gtc atc ttg ggg gac tcc att cag agg gct gtg tac      768
 Asn Lys Phe Val Val Ile Leu Gly Asp Ser Ile Gln Arg Ala Val Tyr
                 245                 250                 255

 aag gac ctg gtg ctc ttg ctc cag aaa gac tca ctg ctc aca gct gcc      816
 Lys Asp Leu Val Leu Leu Leu Gln Lys Asp Ser Leu Leu Thr Ala Ala
             260                 265                 270

 cag ctg aaa gcc aag ggg gag ctg agc ttt gaa cag gac cag ctg gtg      864
 Gln Leu Lys Ala Lys Gly Glu Leu Ser Phe Glu Gln Asp Gln Leu Val
         275                 280                 285

 gct ggg ggc cag ctg ggc gag ctg cac aac ggg aca cag tat cgt gag      912
 Ala Gly Gly Gln Leu Gly Glu Leu His Asn Gly Thr Gln Tyr Arg Glu
     290                 295                 300

 gtc cgc cag ttc tgc tcg ggc tct ggc cac cac ctt gtg cgc ttc tac      960
 Val Arg Gln Phe Cys Ser Gly Ser Gly His His Leu Val Arg Phe Tyr
 305                 310                 315                 320

 ttc ctc act cgt gtt tac tcc gag tac ctt gag gat gtt ctg gaa gag     1008
 Phe Leu Thr Arg Val Tyr Ser Glu Tyr Leu Glu Asp Val Leu Glu Glu
                 325                 330                 335

 ctg aca tat gga cct gcc ccg gac ctg gtg atc atc aac tcc tgc ctc     1056
 Leu Thr Tyr Gly Pro Ala Pro Asp Leu Val Ile Ile Asn Ser Cys Leu
             340                 345                 350

 tgg gat ctc tcc aga tat ggt cgc tgc tca atg gag agc tac cgg gag     1104
 Trp Asp Leu Ser Arg Tyr Gly Arg Cys Ser Met Glu Ser Tyr Arg Glu
         355                 360                 365

 aac ctg gag cgg gtg ttt gtg cgc atg gac caa gta ttg cca gac tcc     1152
 Asn Leu Glu Arg Val Phe Val Arg Met Asp Gln Val Leu Pro Asp Ser
     370                 375                 380

 tgc ctg ctg gtg tgg aac atg gcg atg ccc ctc ggg gaa cgt atc act     1200
 Cys Leu Leu Val Trp Asn Met Ala Met Pro Leu Gly Glu Arg Ile Thr
 385                 390                 395                 400

 ggg ggt ttc ctc ctg cca gag ctc cag ccc ctg gca ggc tcc ctg cgg     1248
 Gly Gly Phe Leu Leu Pro Glu Leu Gln Pro Leu Ala Gly Ser Leu Arg
                 405                 410                 415

 cgg gat gtg gtt gaa ggg aac ttc tac agt gct acg ctg gcc ggg gac     1296
 Arg Asp Val Val Glu Gly Asn Phe Tyr Ser Ala Thr Leu Ala Gly Asp
             420                 425                 430

 cac tgc ttt gat gtc cta gac ctc cac ttt cac ttc cgg cat gca gta     1344
 His Cys Phe Asp Val Leu Asp Leu His Phe His Phe Arg His Ala Val
         435                 440                 445

 cag cac cgt cat cgg gat ggt gtc cac tgg gac cag cat gca cac cgc     1392
 Gln His Arg His Arg Asp Gly Val His Trp Asp Gln His Ala His Arg
     450                 455                 460

 cac ctc tca cac ctg ctt ctg acc cat gtg gct gac gcc tgg ggc gtg     1440
 His Leu Ser His Leu Leu Leu Thr His Val Ala Asp Ala Trp Gly Val
 465                 470                 475                 480

 gag ctg ccc aag cgt ggc tat ccc cct gac ccg tgg att gag gac tgg     1488
 Glu Leu Pro Lys Arg Gly Tyr Pro Pro Asp Pro Trp Ile Glu Asp Trp
                 485                 490                 495

 gca gag atg aat cat cca ttc cag gga agc cat agg cag acc cca gac     1536
 Ala Glu Met Asn His Pro Phe Gln Gly Ser His Arg Gln Thr Pro Asp
             500                 505                 510

 ttc ggg gag cac ctg gcc ttg ctc cca ccc cca cct tct tct ttg cct     1584
 Phe Gly Glu His Leu Ala Leu Leu Pro Pro Pro Pro Ser Ser Leu Pro
         515                 520                 525

 cct ccc atg cct ttt ccc tac cca ctt cct cag ccc tcg cca cct ccc     1632
 Pro Pro Met Pro Phe Pro Tyr Pro Leu Pro Gln Pro Ser Pro Pro Pro
     530                 535                 540

 ctc ttc cca ccc ctg ccc cag gat acc cct ttt ttc cca ggc cag ccc     1680
 Leu Phe Pro Pro Leu Pro Gln Asp Thr Pro Phe Phe Pro Gly Gln Pro
 545                 550                 555                 560

 ttc cca ccc cat gaa ttc ttc aac tat aat cca gtg gag gac ttc tcg     1728
 Phe Pro Pro His Glu Phe Phe Asn Tyr Asn Pro Val Glu Asp Phe Ser
                 565                 570                 575

 atg cca ccc cac tta gga tgt ggc cct gga gtg aac ttt gtg cct ggc     1776
 Met Pro Pro His Leu Gly Cys Gly Pro Gly Val Asn Phe Val Pro Gly
             580                 585                 590

 cct ctg cca cct cca atc cct ggc cct aat ccc cat ggt cag cac tgg     1824
 Pro Leu Pro Pro Pro Ile Pro Gly Pro Asn Pro His Gly Gln His Trp
         595                 600                 605

 ggc cca gtg gtc cac cgg ggg atg cca cgc tat gtt cct aac agc ccc     1872
 Gly Pro Val Val His Arg Gly Met Pro Arg Tyr Val Pro Asn Ser Pro
     610                 615                 620

 tac cat gtg cgg aga atg ggg ggg ccc tgc agg cag cgg ctc aga cac     1920
 Tyr His Val Arg Arg Met Gly Gly Pro Cys Arg Gln Arg Leu Arg His
 625                 630                 635                 640

 tca gag aga ctg atc cac aca tac aaa ctg gac aga cgg cct cct gcc     1968
 Ser Glu Arg Leu Ile His Thr Tyr Lys Leu Asp Arg Arg Pro Pro Ala
                 645                 650                 655

 cat tcg ggg aca tgg cct ggg tag actggatctt gggctgggac tggatgtgcc    2022
 His Ser Gly Thr Trp Pro Gly 
             660

 aatggccctt cagggcctgc ctggcacctc aggtactggg ctagggtgtc tgctatgcct   2082

 ggtattgttc ttgtccattg ctgtcaccaa taaaggcatg gaagaacaaa aa           2134




      <210> 195
      <211> 1929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (464)..(1666)

      <400> 195
 agccccactg ctggccagta attggaattg aggctccctg cacacttgtg agggtctgca     60

 cgttcttccc cctagtatgt tctactagcc ttaacaggta tgtctatgtg gcagatgctg    120

 gttattcaac attcattcag cagtgactgt gtgaagatta atcctatgtg ggtcatgacc    180

 tctggatgct gaaaggaagg tagggctaca gagagaaaaa acatttctcc atgatttcat    240

 tacagatcgc cataaacgct tagcacaact gcaaccgtct tccaagagga atcctcacta    300

 ccagaccttg gagcgggatc ttattgaatt acaggagcag cagctgtttg aactttttgt    360

 ggtggtgtct ctacagaaga aaccatcagg aataagctat attccccagg tcatacaaca    420

 attccctggc aaggatgatc atggctataa gcagtccaaa gac  atg gaa gag aga     475
                                                  Met Glu Glu Arg
                                                    1

 ctt aaa gtt att cca aaa ttt tgt ttt cct gat tca aag gac tgg atg      523
 Leu Lys Val Ile Pro Lys Phe Cys Phe Pro Asp Ser Lys Asp Trp Met
   5                  10                  15                  20

 cca acc tca gaa ctc aag agt gaa aca ttc tcc ttt gtc ttg act ggt      571
 Pro Thr Ser Glu Leu Lys Ser Glu Thr Phe Ser Phe Val Leu Thr Gly
                  25                  30                  35

 gaa gat gga agc cgg tgg ttt ggt tac tgt aag aag ctc ttg cca gta      619
 Glu Asp Gly Ser Arg Trp Phe Gly Tyr Cys Lys Lys Leu Leu Pro Val
              40                  45                  50

 ggc aaa gga aag cga ctc cct gag gta tac tgc atg gtt agt cgc cta      667
 Gly Lys Gly Lys Arg Leu Pro Glu Val Tyr Cys Met Val Ser Arg Leu
          55                  60                  65

 ggc tgc ttc aat ctt ttt tca aag att ctg gat gaa gta gag aag aga      715
 Gly Cys Phe Asn Leu Phe Ser Lys Ile Leu Asp Glu Val Glu Lys Arg
      70                  75                  80

 aga gaa atg tct cca gcc ctt gtt tac cca ttc atg cga agt gtc atg      763
 Arg Glu Met Ser Pro Ala Leu Val Tyr Pro Phe Met Arg Ser Val Met
  85                  90                  95                 100

 gaa gct cct ttc cca gct cct gga cgc acc atc aca gtt aag agt tac      811
 Glu Ala Pro Phe Pro Ala Pro Gly Arg Thr Ile Thr Val Lys Ser Tyr
                 105                 110                 115

 ctc cct ggg gct gga gat gag tcc att gaa ctc tgc cga cca cta gat      859
 Leu Pro Gly Ala Gly Asp Glu Ser Ile Glu Leu Cys Arg Pro Leu Asp
             120                 125                 130

 tcc cga ttg gaa cat gtt gat ttt aaa tgt ctc ttt aag tgc ctg agt      907
 Ser Arg Leu Glu His Val Asp Phe Lys Cys Leu Phe Lys Cys Leu Ser
         135                 140                 145

 gtg tgt cat ctc atc cgg gtc tgt gcc tct ctc ctt ttg gag cgt agg      955
 Val Cys His Leu Ile Arg Val Cys Ala Ser Leu Leu Leu Glu Arg Arg
     150                 155                 160

 gta atc ttt gtt gcc aac agc cta agc acc ctg tca aaa tgt ggc cat     1003
 Val Ile Phe Val Ala Asn Ser Leu Ser Thr Leu Ser Lys Cys Gly His
 165                 170                 175                 180

 gct gtg gta gct aca ctg tat ccg ttc acc tgg cag cat acc tat atc     1051
 Ala Val Val Ala Thr Leu Tyr Pro Phe Thr Trp Gln His Thr Tyr Ile
                 185                 190                 195

 cca gtc ctg cca gca tct atg att gac atc gtg tgc tca cct aca cca     1099
 Pro Val Leu Pro Ala Ser Met Ile Asp Ile Val Cys Ser Pro Thr Pro
             200                 205                 210

 ttc ctt att gga atc ctg tct tgc tcc tta cca cag ctc cag gac cta     1147
 Phe Leu Ile Gly Ile Leu Ser Cys Ser Leu Pro Gln Leu Gln Asp Leu
         215                 220                 225

 ccc att gaa gag gtg ctg ata gtt gat ctc tgt gca gac aag ttc tta     1195
 Pro Ile Glu Glu Val Leu Ile Val Asp Leu Cys Ala Asp Lys Phe Leu
     230                 235                 240

 cag gag gta tct gat gag gat gaa att cta cca cca aaa ctt caa gct     1243
 Gln Glu Val Ser Asp Glu Asp Glu Ile Leu Pro Pro Lys Leu Gln Ala
 245                 250                 255                 260

 gcc ctg atg cag att ttg gaa gaa cga aat gaa atc ttg act cag gag     1291
 Ala Leu Met Gln Ile Leu Glu Glu Arg Asn Glu Ile Leu Thr Gln Glu
                 265                 270                 275

 cag aat ttt tca caa gca gat gtg aca ctc aac tct ctg gtg tcc gaa     1339
 Gln Asn Phe Ser Gln Ala Asp Val Thr Leu Asn Ser Leu Val Ser Glu
             280                 285                 290

 gca ttt gtc agg ttt ttt gtg gag ttg gta gga cat tat tct ttg aac     1387
 Ala Phe Val Arg Phe Phe Val Glu Leu Val Gly His Tyr Ser Leu Asn
         295                 300                 305

 atg act gtc act gag cgt ggg gag cgt gtt ttc caa agg gaa cca ttc     1435
 Met Thr Val Thr Glu Arg Gly Glu Arg Val Phe Gln Arg Glu Pro Phe
     310                 315                 320

 cgt aag tcc cac acc tcc cga agt gta cgc cac ttc ctg gat ctc ttc     1483
 Arg Lys Ser His Thr Ser Arg Ser Val Arg His Phe Leu Asp Leu Phe
 325                 330                 335                 340

 atg gaa act cag atg ttt gca gga ttc atc cag gac cga gag ctt cgg     1531
 Met Glu Thr Gln Met Phe Ala Gly Phe Ile Gln Asp Arg Glu Leu Arg
                 345                 350                 355

 aaa agt gga gtt aaa ggt ttg ttt gag atc cgg gcc atc cag tat ttg     1579
 Lys Ser Gly Val Lys Gly Leu Phe Glu Ile Arg Ala Ile Gln Tyr Leu
             360                 365                 370

 gaa aca att cct gag tcg gag ccc agt ggg atg aat aga att ttg cgg     1627
 Glu Thr Ile Pro Glu Ser Glu Pro Ser Gly Met Asn Arg Ile Leu Arg
         375                 380                 385

 agt ctt gga agc aaa atg aaa ttt ctg caa aag aaa tga aatctctgat      1676
 Ser Leu Gly Ser Lys Met Lys Phe Leu Gln Lys Lys 
     390                 395                 400

 tgtctccatc ctgaatatac aacagaaagt gccaaagaaa atatttttct aagggtcagg   1736

 atcccatgaa gtattctaca aaattcttga aattttaaaa ggttaaagag cgagtcaggc   1796

 tgtcagagga ggattctcct gttgctgctg tagtaatcac tggagaattg ttgggaatgg   1856

 tctggcccca tgccatcttt actctgtctc catttttttt ttatagcagc cttttctatg   1916

 tgaaaaaaaa aaa                                                      1929




      <210> 196
      <211> 1042
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (605)..(988)

      <400> 196
 gccgtcccca aagctcgctg ttcgcttcgc tgcctgacag gtgccctgcc gccaccaggc     60

 agtcccagct tccccaaacc agtcttctgg cctctgtggc gccccaggcc cgcgggattc    120

 agggattagg atctggaagg gtttggtcca atcccctatc cctctcagcg tcctgggctc    180

 acctccccgg cagcttagcg ctcctcttcc aaaactgctt gctgttctca gcggccattg    240

 ctctggccgg gggaagtcct tgtaggcggg ccaagggttt gcccggcgag atgcccccag    300

 accccgcaat ctgagggcca acccaggccg cttccccgcc gccggtcacc cgctcccagc    360

 tcctggggac gccatcttgg atgtgggcac ccctccaccc agcaccgctg ccattggtga    420

 gctgcgcaag ccgtggacgg gccgaccaat tgggagccgg aatcctgcag gccgctgaag    480

 ccgaccggta acgtcagggg ctgggcacac aggtggacgg ggaaggcgga gcttggacga    540

 gccgagaggc ggggctcaaa gttcctaccc gcgagaggga agaagcaggt aaggaggtct    600

 cagc atg aaa cag cag cag tgg tgt ggg atg act gcc aaa atg ggc acc     649
      Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr
        1               5                  10                  15

 gtg ttg tca ggg gtc ttc acc atc atg gcc gta gac atg tat ctc atc      697
 Val Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile
                  20                  25                  30

 ttt gaa cag aag cac cta ggg aat ggc agt tgc act gag atc aca cca      745
 Phe Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro
              35                  40                  45

 aag tac agg ggt gca agt aac atc ata aat aac ttc atc atc tgc tgg      793
 Lys Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp
          50                  55                  60

 agt ttt aaa atc gtc ctc ttc ctg tct ttc atc acc atc ctc atc agc      841
 Ser Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser
      65                  70                  75

 tgc ttc ctc ctg tac tca gtg tat gcc cag atc ttc agg ggc ctg gtc      889
 Cys Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val
  80                  85                  90                  95

 atc tac att gtc tgg att ttt ttc tat gaa act gca aac gtc gta ata      937
 Ile Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile
                 100                 105                 110

 caa atc ctc acc aac aat gac ttt gac att aaa gag gag gtg ctc tgg      985
 Gln Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Glu Val Leu Trp
             115                 120                 125

 taa aaca agtataaaat gaatgtcagg atgttctccc tcatggtggg catcttctct     1042
 






      <210> 197
      <211> 657
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(657)

      <400> 197
  atg aaa cag cag cag tgg tgt ggg atg act gcc aaa atg ggc acc gtg      48
  Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val
    1               5                  10                  15

 ttg tca ggg gtc ttc acc atc atg gcc gta gac atg tat ctc atc ttt       96
 Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe
              20                  25                  30

 gaa cag aag cac cta ggg aat ggc agt tgc act gag atc aca cca aag      144
 Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys
          35                  40                  45

 tac agg ggt gca agt aac atc ata aat aac ttc atc atc tgc tgg agt      192
 Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser
      50                  55                  60

 ttt aaa atc gtc ctc ttc ctg tct ttc atc acc atc ctc atc agc tgc      240
 Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys
  65                  70                  75                  80

 ttc ctc ctg tac tca gtg tat gcc cag atc ttc agg ggc ctg gtc atc      288
 Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile
                  85                  90                  95

 tac att gtc tgg att ttt ttc tat gaa act gca aac gtc gta ata caa      336
 Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln
             100                 105                 110

 atc ctc acc aac aat gac ttt gac att aaa gag gtc aga atc atg cgc      384
 Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg
         115                 120                 125

 tgg ttt ggc ttg gtg tct cgt aca gtc atg cac tgt ttc tgg atg ttc      432
 Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe
     130                 135                 140

 ttt gtc atc aac tat gcc cac ata acc tac aaa aac cgg agc cag ggc      480
 Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly
 145                 150                 155                 160

 aat ata att tcc tac aag aga cga att tct aca gcg gag att ctc cac      528
 Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His
                 165                 170                 175

 agc aga aat aaa aga tta tca att tcg att ctg caa gta gag acc cta      576
 Ser Arg Asn Lys Arg Leu Ser Ile Ser Ile Leu Gln Val Glu Thr Leu
             180                 185                 190

 ctg cca ctc ttt cag gag aac atg aag aga aaa tgt gat tat aat cac      624
 Leu Pro Leu Phe Gln Glu Asn Met Lys Arg Lys Cys Asp Tyr Asn His
         195                 200                 205

 aac cgg aac atc ctg ctc att gag ggt att tag                          657
 Asn Arg Asn Ile Leu Leu Ile Glu Gly Ile 
     210                 215





      <210> 198
      <211> 2076
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (34)..(759)

      <400> 198
 tgaaccgagg caagggggcg cggcgcacgc agt atg gcg ccc aac atc tac ttg      54
                                      Met Ala Pro Asn Ile Tyr Leu
                                        1               5

 gtt cgc cag cgg atc agt cga ctc ggc cag agg atg tcc ggc ttc cag      102
 Val Arg Gln Arg Ile Ser Arg Leu Gly Gln Arg Met Ser Gly Phe Gln
          10                  15                  20

 atc aac ctc aac ccg ctc aag gag cca ctc ggc ttc atc aag gtc ctc      150
 Ile Asn Leu Asn Pro Leu Lys Glu Pro Leu Gly Phe Ile Lys Val Leu
      25                  30                  35

 gag tgg att gct tct atc ttt gct ttt gcc acc tgt gga ggt ttt aag      198
 Glu Trp Ile Ala Ser Ile Phe Ala Phe Ala Thr Cys Gly Gly Phe Lys
  40                  45                  50                  55

 ggc caa aca gaa att caa gtg aat tgt cct cct gca gtt act gag aat      246
 Gly Gln Thr Glu Ile Gln Val Asn Cys Pro Pro Ala Val Thr Glu Asn
                  60                  65                  70

 cag cca cct cca ggt gta aac ata tgt gat gta aat tgg aaa gat tac      294
 Gln Pro Pro Pro Gly Val Asn Ile Cys Asp Val Asn Trp Lys Asp Tyr
              75                  80                  85

 gtc ctc ata ggc gat tac tct tct tct gca caa ttc tat gtt acc ttt      342
 Val Leu Ile Gly Asp Tyr Ser Ser Ser Ala Gln Phe Tyr Val Thr Phe
          90                  95                 100

 gca gtc ttt gtg ttc ctg tac tgc att gct gcc ctt ctg ctt tat gtt      390
 Ala Val Phe Val Phe Leu Tyr Cys Ile Ala Ala Leu Leu Leu Tyr Val
     105                 110                 115

 ggc tac acg agt ctg tat ctg gat agt cgt aaa ctt cct atg ata gac      438
 Gly Tyr Thr Ser Leu Tyr Leu Asp Ser Arg Lys Leu Pro Met Ile Asp
 120                 125                 130                 135

 ttt gtt gtt aca ctt gtt gcc act ttt ttg tgg ttg gtg agc act tca      486
 Phe Val Val Thr Leu Val Ala Thr Phe Leu Trp Leu Val Ser Thr Ser
                 140                 145                 150

 gcc tgg gct aaa gct ctg aca gat att aaa ata gct act ggt cac aat      534
 Ala Trp Ala Lys Ala Leu Thr Asp Ile Lys Ile Ala Thr Gly His Asn
             155                 160                 165

 att att gat gaa ctt ccg cct tgt aag aag aaa gca gta ctg tgt tac      582
 Ile Ile Asp Glu Leu Pro Pro Cys Lys Lys Lys Ala Val Leu Cys Tyr
         170                 175                 180

 ttt ggc tct gtg acc agt atg gga tcc cta aat gta tct gtg ata ttt      630
 Phe Gly Ser Val Thr Ser Met Gly Ser Leu Asn Val Ser Val Ile Phe
     185                 190                 195

 ggc ttt cta aat atg ata ctc tgg gga gga aat gct tgg ttt gtg tac      678
 Gly Phe Leu Asn Met Ile Leu Trp Gly Gly Asn Ala Trp Phe Val Tyr
 200                 205                 210                 215

 aag gag acc agc cta cac agt cca tca aat aca tct gcc cct cat agc      726
 Lys Glu Thr Ser Leu His Ser Pro Ser Asn Thr Ser Ala Pro His Ser
                 220                 225                 230

 caa gga ggt att cca cct cct acc gga ata taa ttaaaggg agaaatacac      777
 Gln Gly Gly Ile Pro Pro Pro Thr Gly Ile 
             235                 240

 tgtatgaagt atatgttgat actatgacat gttgccaaca ccttgagaag cattatttgt    837

 ttctaataaa agtaatggct ttgtcaatat attggtgggt ttaaaacttt gctgcttttt    897

 tacataaagc ctgtgccttt cctagaaagt taagatgtaa atgtattctc acatgtaaat    957

 ttgaaagttc aggggtctat tatgaaatgg attacacatt tttaaatgaa cccataattt   1017

 ttttcactaa agctgtttgc cctccaaagt gtttacacct taagccttaa catgtatcgc   1077

 tcattcagaa aactgttata ttgtcatacc atagtaggaa gaaaaacctt tatttggaat   1137

 atacactact gtaagtttgt acagatcata tacctaccac ctgtctttgc ttaaagagcc   1197

 ttgattacat aaatatgtag gaaaaaacat attgagttca aaatttatat ctaacattgt   1257

 ttatgttatg attttttttt aattgcaaag actaggtgta tatttttttc tgtttttcta   1317

 aatgacccgt ggtacttaat aggtgtacta aaattgtgtt gggagcaggg atttggaaat   1377

 ttctgagaga tgtgtagtta atttagtaat tctgtttcat gagatatgat ctgttatgct   1437

 agtggtttaa taggcttgct atgtaagtag aacgtggctc aactagatat ctttatatgt   1497

 atgggcatta cctcttagtg atatttgttt cctgtccttt gttgctcatg ctgtttaagt   1557

 gcaggctgag acccagcctc tttgtaagta cagtaaaata atccaccgtt ttttacagac   1617

 cctagtcaaa gggttaaaaa aattaagatt gctttccatg tttgaaattt accattgaga   1677

 gtcaatgaag ttgctatttt gagtttagca ttgatattgt gaaaataagt gcaatttgga   1737

 tttcatgttt cttaatattc attcttgttt cacaaatgaa tgattaagga attatgcatc   1797

 ataaaggaac ctaagtgagg tatatgatga gtgtattgtc tttgcacaca catataggta   1857

 tattctgaat acaagcttat tcacattttg cttcctaatc tttttgttgt acagggattc   1917

 aggtttctta ttcttacaac atgattgttt atatgtgaag cacatcttgc tgttgcctta   1977

 tttttgatgc ttttattcat gacaagaatt gtcaatataa gaatgtatat cttttttgca   2037

 accaatttaa taaaggagtt gaaagaaaaa aaaaaaaaa                          2076




      <210> 199
      <211> 1732
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(1277)

      <400> 199
 ccgcccacgt c atg gcg ccc gag gag aac gcg ggg acc gaa ctc ttg ctg      50
              Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu Leu
                1               5                  10

 cag agt ttc gag cgc cgc ttc ctg gcg gca cgc aca ctg cgc tcc ttc       98
 Gln Ser Phe Glu Arg Arg Phe Leu Ala Ala Arg Thr Leu Arg Ser Phe
      15                  20                  25

 ccc tgg cag agc tta gaa gca aag tta aga gac tca tca gat tct gag      146
 Pro Trp Gln Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu
  30                  35                  40                  45

 ctg ctg cgg gat att ttg cac aag act gtg aag cat cct gtg tgt gtg      194
 Leu Leu Arg Asp Ile Leu His Lys Thr Val Lys His Pro Val Cys Val
                  50                  55                  60

 aag cac ccg ccg tcc gtc aaa tat gcc cgg tgc ttt ctc tca gaa ctc      242
 Lys His Pro Pro Ser Val Lys Tyr Ala Arg Cys Phe Leu Ser Glu Leu
              65                  70                  75

 atc aaa aag ccc tcg gga ggc tcg gtc aca ctc tcc gag agc acg gcc      290
 Ile Lys Lys Pro Ser Gly Gly Ser Val Thr Leu Ser Glu Ser Thr Ala
          80                  85                  90

 atc atc tcc tac ggt acc aca ggc ctg gtc aca tgg gac gcc gcc ctc      338
 Ile Ile Ser Tyr Gly Thr Thr Gly Leu Val Thr Trp Asp Ala Ala Leu
      95                 100                 105

 tac ctt gca gaa tgg gcc atc gag aac ccg gca gtc ttc act aac agg      386
 Tyr Leu Ala Glu Trp Ala Ile Glu Asn Pro Ala Val Phe Thr Asn Arg
 110                 115                 120                 125

 act gtc cta gag ctt ggc agt ggt gct ggc ctc aca ggc ctg gcc atc      434
 Thr Val Leu Glu Leu Gly Ser Gly Ala Gly Leu Thr Gly Leu Ala Ile
                 130                 135                 140

 tgc aag atg tgc cgc ccc cgg gca tac atc ttc agc gac tgt cac agc      482
 Cys Lys Met Cys Arg Pro Arg Ala Tyr Ile Phe Ser Asp Cys His Ser
             145                 150                 155

 cgg gtc ctt gag cag ctc cga ggg aat gtc ctt ctc aat ggc ctc tca      530
 Arg Val Leu Glu Gln Leu Arg Gly Asn Val Leu Leu Asn Gly Leu Ser
         160                 165                 170

 tta gag gca gac atc act gcc aag tta gac agc ccc agg gtg aca gtg      578
 Leu Glu Ala Asp Ile Thr Ala Lys Leu Asp Ser Pro Arg Val Thr Val
     175                 180                 185

 gcc cag ctg gac tgg gac gtc gcg acg gtc cat cag ctc tct gcc ttc      626
 Ala Gln Leu Asp Trp Asp Val Ala Thr Val His Gln Leu Ser Ala Phe
 190                 195                 200                 205

 cag cca gat gtt gtc att gca gca gat gtg ctg tat tgc cca gaa gcc      674
 Gln Pro Asp Val Val Ile Ala Ala Asp Val Leu Tyr Cys Pro Glu Ala
                 210                 215                 220

 atc atg tcg ctg gtc ggc gtc ctg cgg agg ctg gct gcc tgc cgg gag      722
 Ile Met Ser Leu Val Gly Val Leu Arg Arg Leu Ala Ala Cys Arg Glu
             225                 230                 235

 gac cag cgg gct cct gag gtc tac gtg gcc ttt acc gtc cgc aac cca      770
 Asp Gln Arg Ala Pro Glu Val Tyr Val Ala Phe Thr Val Arg Asn Pro
         240                 245                 250

 gag acg tgc cag ctg ttc acc acc gag cta gct gag ccc cca cac gca      818
 Glu Thr Cys Gln Leu Phe Thr Thr Glu Leu Ala Glu Pro Pro His Ala
     255                 260                 265

 ccc ggg cct gca tgg tcc ctg agc tgt ccc tgc agg act cca gtg gaa      866
 Pro Gly Pro Ala Trp Ser Leu Ser Cys Pro Cys Arg Thr Pro Val Glu
 270                 275                 280                 285

 gtg aaa gaa ctg ggc acc ggg gaa aag cta gga tgt ccc aca ctc cta      914
 Val Lys Glu Leu Gly Thr Gly Glu Lys Leu Gly Cys Pro Thr Leu Leu
                 290                 295                 300

 cac cat gca ggg aac tcg ggc aca ggc cgg act gtc cta gaa ctt ggc      962
 His His Ala Gly Asn Ser Gly Thr Gly Arg Thr Val Leu Glu Leu Gly
             305                 310                 315

 agt ggt gcc ggc ctc aca ggc ctt gcc atc tgc aag atg tgc cgc ccc     1010
 Ser Gly Ala Gly Leu Thr Gly Leu Ala Ile Cys Lys Met Cys Arg Pro
         320                 325                 330

 cgg gca tac atc ttc agc gac cct cac agc cgg gtc ctc gag cag ctc     1058
 Arg Ala Tyr Ile Phe Ser Asp Pro His Ser Arg Val Leu Glu Gln Leu
     335                 340                 345

 caa ggg aat gtc ttt ctc aat ggc ctc tca tta gag gca gac atc act     1106
 Gln Gly Asn Val Phe Leu Asn Gly Leu Ser Leu Glu Ala Asp Ile Thr
 350                 355                 360                 365

 gcc aac tta gac agc ccc agg gtg aca gtg gcc cag ctg gac tgg gac     1154
 Ala Asn Leu Asp Ser Pro Arg Val Thr Val Ala Gln Leu Asp Trp Asp
                 370                 375                 380

 gta gcg acg gtc cat cag ctc tct gcc ttc cag cca gat gtt gtc att     1202
 Val Ala Thr Val His Gln Leu Ser Ala Phe Gln Pro Asp Val Val Ile
             385                 390                 395

 gca gca ggt aat gcc cag ccc cgg gca ccc tgt gca ggc ggt gtc ctt     1250
 Ala Ala Gly Asn Ala Gln Pro Arg Ala Pro Cys Ala Gly Gly Val Leu
         400                 405                 410

 gca gct cta ccc agc tct tgg ctc tag aagcg ggggtagtcc tcggccctcc     1302
 Ala Ala Leu Pro Ser Ser Trp Leu 
     415                 420

 agccaggggg tgcagacctg gatgtgctgg aaatgcttct ggtggatgag gcggctgtaa   1362

 tactccctca gaggcccttt gccttcacag agaaaagcag acactgccat ggacccgtct   1422

 ctgtccctgc cacatggctc ccggcccaag acactccccc taggagggat cctttcccca   1482

 gaagctccac ccctcggcag ctccagtcag gccccatctg tgcccttcca gaagcaaccc   1542

 aggagccccg agacctgcag ggatgtgtga ccctgacccc tgacgcctaa ccctgacctg   1602

 cagcagatgg ctcgggctac aaacatggcg gggtaagcac tggcctggca ccccaccgcc   1662

 cactgggtgg acccagcctt ctgtctgtgt tgtcgcaggg gacacgagga ctcccccacg   1722

 aagtcgtcga                                                          1732




      <210> 200
      <211> 2607
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (135)..(2549)

      <400> 200
 gcggggcgcc aaggggcgcg ccaggagccg cgcgggcgct gggagggagt ccagggcgca     60

 gttccgggcg cgtctgagcg gttctcgagg cgttctcgcc tcggtctctg gcgagtgcac    120

 ggatcaaaag cagc  atg gat ctg cct gtg gat gaa tgg aaa tca tat ctg     170
                  Met Asp Leu Pro Val Asp Glu Trp Lys Ser Tyr Leu
                    1               5                  10

 ctt caa aag tgg gct tca ctc ccg acg tct gtt cag gtc aca att tct      218
 Leu Gln Lys Trp Ala Ser Leu Pro Thr Ser Val Gln Val Thr Ile Ser
          15                  20                  25

 aca gca gag acc ttg agg gat atc ttt ctt cac tcc tct tca ctt ctt      266
 Thr Ala Glu Thr Leu Arg Asp Ile Phe Leu His Ser Ser Ser Leu Leu
      30                  35                  40

 caa cct gag gat gag ctg ttt cta aaa aga ctt tct aaa ggt tac ttg      314
 Gln Pro Glu Asp Glu Leu Phe Leu Lys Arg Leu Ser Lys Gly Tyr Leu
  45                  50                  55                  60

 gtg gga aag gac tcg gac gct cct ctt ttc tac aga gaa gaa gga aac      362
 Val Gly Lys Asp Ser Asp Ala Pro Leu Phe Tyr Arg Glu Glu Gly Asn
                  65                  70                  75

 aaa aaa ttt cag gag aaa gat tac aca gga gct gca gtg ctg tac tct      410
 Lys Lys Phe Gln Glu Lys Asp Tyr Thr Gly Ala Ala Val Leu Tyr Ser
              80                  85                  90

 aag gga gtg tca cat tca agg cct aac act gag gac atg tca ctg tgt      458
 Lys Gly Val Ser His Ser Arg Pro Asn Thr Glu Asp Met Ser Leu Cys
          95                 100                 105

 cat gct aac cgc tcg gca gcc ctc ttc cac ctg ggt cag tat gag acg      506
 His Ala Asn Arg Ser Ala Ala Leu Phe His Leu Gly Gln Tyr Glu Thr
     110                 115                 120

 tgt ctt aaa gac att aac ata gca cag aca cat ggg tat cca gaa agg      554
 Cys Leu Lys Asp Ile Asn Ile Ala Gln Thr His Gly Tyr Pro Glu Arg
 125                 130                 135                 140

 ttg caa ccc aag att atg tta cgt aaa gca gaa tgt ctg gtg gcc ctg      602
 Leu Gln Pro Lys Ile Met Leu Arg Lys Ala Glu Cys Leu Val Ala Leu
                 145                 150                 155

 ggg aga ctg cag gag gca agc cag acc atc agt gat ctt gaa agg aac      650
 Gly Arg Leu Gln Glu Ala Ser Gln Thr Ile Ser Asp Leu Glu Arg Asn
             160                 165                 170

 ttc aca gcc aca cca gcc cta gca gat gtc ctc cct cag act ctg cag      698
 Phe Thr Ala Thr Pro Ala Leu Ala Asp Val Leu Pro Gln Thr Leu Gln
         175                 180                 185

 aga aac ctc cat cgt ctg aaa atg aag atg caa gaa aag gac agt ctc      746
 Arg Asn Leu His Arg Leu Lys Met Lys Met Gln Glu Lys Asp Ser Leu
     190                 195                 200

 aca gaa agc ttc cca gca gct ctg gcc aaa acc ctt gag gat gca gcg      794
 Thr Glu Ser Phe Pro Ala Ala Leu Ala Lys Thr Leu Glu Asp Ala Ala
 205                 210                 215                 220

 ctg agg gag gag aat gaa caa ctt tcc aat gcc tca tca tcc atc ggc      842
 Leu Arg Glu Glu Asn Glu Gln Leu Ser Asn Ala Ser Ser Ser Ile Gly
                 225                 230                 235

 tta tgc gta gat cct tta aaa ggt cgc tgt ctc gtt gcc aca aaa gat      890
 Leu Cys Val Asp Pro Leu Lys Gly Arg Cys Leu Val Ala Thr Lys Asp
             240                 245                 250

 att ctc cca gga gag ctc ctg gtg cag gag gat gct ttt gtg agt gtt      938
 Ile Leu Pro Gly Glu Leu Leu Val Gln Glu Asp Ala Phe Val Ser Val
         255                 260                 265

 ctc aac cca gga gaa ctg cca cca ccg cat cac ggc cta gac agc aaa      986
 Leu Asn Pro Gly Glu Leu Pro Pro Pro His His Gly Leu Asp Ser Lys
     270                 275                 280

 tgg gac acc aga gtc acc aat ggg gac ctc tat tgt cac cga tgt ttg     1034
 Trp Asp Thr Arg Val Thr Asn Gly Asp Leu Tyr Cys His Arg Cys Leu
 285                 290                 295                 300

 aag cac act ttg gcc aca gtt ccg tgt gac gga tgc agt tat gcc aag     1082
 Lys His Thr Leu Ala Thr Val Pro Cys Asp Gly Cys Ser Tyr Ala Lys
                 305                 310                 315

 tat tgc agc cag gag tgt ttg cag cag gcc tgg gag ctc tac cac agg     1130
 Tyr Cys Ser Gln Glu Cys Leu Gln Gln Ala Trp Glu Leu Tyr His Arg
             320                 325                 330

 aca gaa tgt cct ctg gga ggg ctg ctt ctc aca ctg ggt gtc ttt tgc     1178
 Thr Glu Cys Pro Leu Gly Gly Leu Leu Leu Thr Leu Gly Val Phe Cys
         335                 340                 345

 cac att gcc ctg agg ttg act ctt ttg gtg gga ttt gag gat gtt cgc     1226
 His Ile Ala Leu Arg Leu Thr Leu Leu Val Gly Phe Glu Asp Val Arg
     350                 355                 360

 aaa atc ata acg aag ctt tgt gat aag att agt aac aag gac atc tgt     1274
 Lys Ile Ile Thr Lys Leu Cys Asp Lys Ile Ser Asn Lys Asp Ile Cys
 365                 370                 375                 380

 tta cgt gaa agc aac aat cag gtc aag aca ctt aat tat ggc cta ggg     1322
 Leu Arg Glu Ser Asn Asn Gln Val Lys Thr Leu Asn Tyr Gly Leu Gly
                 385                 390                 395

 gag agt gag aaa aat ggc aac atc gtt gag acc cca att cct gga tgc     1370
 Glu Ser Glu Lys Asn Gly Asn Ile Val Glu Thr Pro Ile Pro Gly Cys
             400                 405                 410

 gat att aat ggg aag tat gaa aat aat tat aat gct gtc ttc aac ctt     1418
 Asp Ile Asn Gly Lys Tyr Glu Asn Asn Tyr Asn Ala Val Phe Asn Leu
         415                 420                 425

 ttg ccc cac act gaa aac cat agc cca gag cac aaa ttc ctc tgt gct     1466
 Leu Pro His Thr Glu Asn His Ser Pro Glu His Lys Phe Leu Cys Ala
     430                 435                 440

 ctc tgt gtt tct gca ctg tgc aga cag cta gaa gca gcc agt tta cag     1514
 Leu Cys Val Ser Ala Leu Cys Arg Gln Leu Glu Ala Ala Ser Leu Gln
 445                 450                 455                 460

 gcc atc cca act gag agg att gtg aac tcc tct cag ctt aaa gca gca     1562
 Ala Ile Pro Thr Glu Arg Ile Val Asn Ser Ser Gln Leu Lys Ala Ala
                 465                 470                 475

 gtg aca cct gaa ttg tgt cct gac gtg act att tgg gga gtg gcg atg     1610
 Val Thr Pro Glu Leu Cys Pro Asp Val Thr Ile Trp Gly Val Ala Met
             480                 485                 490

 ctg aga cac atg tta cag ctt cag tgt aac gct cag gcg atg acc acc     1658
 Leu Arg His Met Leu Gln Leu Gln Cys Asn Ala Gln Ala Met Thr Thr
         495                 500                 505

 ata caa cac aca gga cct aaa ggg agc atc gtt acc gac agc agg cag     1706
 Ile Gln His Thr Gly Pro Lys Gly Ser Ile Val Thr Asp Ser Arg Gln
     510                 515                 520

 gtg cgc ctt gcc aca ggc atc ttc cct gtt atc agc ctc ctg aac cac     1754
 Val Arg Leu Ala Thr Gly Ile Phe Pro Val Ile Ser Leu Leu Asn His
 525                 530                 535                 540

 tcc tgt agc ccc aac acc agc gtg tcc ttc att agc act gtc gcc acc     1802
 Ser Cys Ser Pro Asn Thr Ser Val Ser Phe Ile Ser Thr Val Ala Thr
                 545                 550                 555

 atc cgg gcg tca cag cgg att aga aag ggg caa gag att ctc cac tgc     1850
 Ile Arg Ala Ser Gln Arg Ile Arg Lys Gly Gln Glu Ile Leu His Cys
             560                 565                 570

 tat ggg cct cac aag agc cgg atg ggg gtt gcc gaa agg cag cag aag     1898
 Tyr Gly Pro His Lys Ser Arg Met Gly Val Ala Glu Arg Gln Gln Lys
         575                 580                 585

 ctg agg tct cag tat ttc ttt gac tgc gcc tgt cca gct tgt caa act     1946
 Leu Arg Ser Gln Tyr Phe Phe Asp Cys Ala Cys Pro Ala Cys Gln Thr
     590                 595                 600

 gag gca cac agg atg gct gca ggg ccc agg tgg gaa gca ttc tgt tgc     1994
 Glu Ala His Arg Met Ala Ala Gly Pro Arg Trp Glu Ala Phe Cys Cys
 605                 610                 615                 620

 aac agt tgc gga gcg ccc atg cag gga gat gac gtg ctg cgc tgt ggc     2042
 Asn Ser Cys Gly Ala Pro Met Gln Gly Asp Asp Val Leu Arg Cys Gly
                 625                 630                 635

 agc aga tct tgt gca gaa tcc gcc gtc agc agg gac cac ctg gtc tct     2090
 Ser Arg Ser Cys Ala Glu Ser Ala Val Ser Arg Asp His Leu Val Ser
             640                 645                 650

 cgg tta cag gac cta cag cag cag gtc aga gtg gcc cag aag ctt ctc     2138
 Arg Leu Gln Asp Leu Gln Gln Gln Val Arg Val Ala Gln Lys Leu Leu
         655                 660                 665

 aga gat ggt gaa cta gag cga gct gtt cag cgg ctg tcg ggg tgc cag     2186
 Arg Asp Gly Glu Leu Glu Arg Ala Val Gln Arg Leu Ser Gly Cys Gln
     670                 675                 680

 cgt gac gcc gag agc ttc ctg tgg gca gag cac gcc gtg gtg gga gag     2234
 Arg Asp Ala Glu Ser Phe Leu Trp Ala Glu His Ala Val Val Gly Glu
 685                 690                 695                 700

 atc gcg gat ggc ctg gcc cgg gcc tgt gct gcc tta gga gac tgg caa     2282
 Ile Ala Asp Gly Leu Ala Arg Ala Cys Ala Ala Leu Gly Asp Trp Gln
                 705                 710                 715

 aag tca gcc acc cat cta cag agg agt ctc tgc gtg gtg gag gtt cgc     2330
 Lys Ser Ala Thr His Leu Gln Arg Ser Leu Cys Val Val Glu Val Arg
             720                 725                 730

 cac ggg ccg tcc agt gtt gaa atg ggc cat gag ctc ttc aaa ttg gcc     2378
 His Gly Pro Ser Ser Val Glu Met Gly His Glu Leu Phe Lys Leu Ala
         735                 740                 745

 cag atc ttt ttc aac ggg ttt gca gta ccc gaa gcc ctg agc aca ata     2426
 Gln Ile Phe Phe Asn Gly Phe Ala Val Pro Glu Ala Leu Ser Thr Ile
     750                 755                 760

 cag aaa gct gag gag gtt ctg tcg ctg cac tgt ggc cca tgg gac gat     2474
 Gln Lys Ala Glu Glu Val Leu Ser Leu His Cys Gly Pro Trp Asp Asp
 765                 770                 775                 780

 gaa atc cag gag ctc cag aag atg aaa tcc tgt ttg ttg gac tta cca     2522
 Glu Ile Gln Glu Leu Gln Lys Met Lys Ser Cys Leu Leu Asp Leu Pro
                 785                 790                 795

 ccc acc cct gta ggg cct gca ttg tag ggttc caggaggatt ttgacccaca     2574
 Pro Thr Pro Val Gly Pro Ala Leu 
             800

 gaaaaggagc ccatggaaca caagttaaag agg                                2607




      <210> 201
      <211> 1210
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(1107)

      <400> 201
 ccgcaacgga acgaggaacc cggacagtga aggaggaaga aacaaaggag ccagcagcac     60

 tagagagttc ccttctggag gaaaactagt gtttctgcta ctgcttcagt gagcgcaact    120

 aatctgatca gc    atg gtc cag gga cag ttg aga gtt ctt ggg caa gag     168
                  Met Val Gln Gly Gln Leu Arg Val Leu Gly Gln Glu
                    1               5                  10

 ggg aat ctg ctg ctg cat cga acc tca gag gat cca gaa cgg cag ctg      216
 Gly Asn Leu Leu Leu His Arg Thr Ser Glu Asp Pro Glu Arg Gln Leu
          15                  20                  25

 gtc ctt gct ggg ctg ttc ctg tcc atg tgc ctg gtc acg gtg ctg ggg      264
 Val Leu Ala Gly Leu Phe Leu Ser Met Cys Leu Val Thr Val Leu Gly
      30                  35                  40

 aac ctg atc atc atc ctg gac gtc agc cct gac tcc cac ctc ccc acc      312
 Asn Leu Ile Ile Ile Leu Asp Val Ser Pro Asp Ser His Leu Pro Thr
  45                  50                  55                  60

 ccc atg tac ttc ttc ctc tcc aac ctg tcc ttg cct gac atc ggt ttc      360
 Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Pro Asp Ile Gly Phe
                  65                  70                  75

 acc tcc acc acg gtc ccc aag atg att gtg gac atg caa act cac agc      408
 Thr Ser Thr Thr Val Pro Lys Met Ile Val Asp Met Gln Thr His Ser
              80                  85                  90

 aga gtc atc tcc tat gaa ggc tgc ctg act cag atg tct ttt ttt gtc      456
 Arg Val Ile Ser Tyr Glu Gly Cys Leu Thr Gln Met Ser Phe Phe Val
          95                 100                 105

 ctt ttt gca tgt atg gat gac atg ctc ctg agt gtg atg gcc tat gac      504
 Leu Phe Ala Cys Met Asp Asp Met Leu Leu Ser Val Met Ala Tyr Asp
     110                 115                 120

 cgg ttt gtg gcc atc tgt cac ccc ctg cac tac cga atc atc atg aac      552
 Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Arg Ile Ile Met Asn
 125                 130                 135                 140

 cca cgc ctc tgt ggc ttc tta atc ttg ttg tct ttt ttt att agt ctt      600
 Pro Arg Leu Cys Gly Phe Leu Ile Leu Leu Ser Phe Phe Ile Ser Leu
                 145                 150                 155

 ttg gac tcc cag ttg cac aat ttg att atg tta cag ctc acc tgc ttc      648
 Leu Asp Ser Gln Leu His Asn Leu Ile Met Leu Gln Leu Thr Cys Phe
             160                 165                 170

 aag gat gtg gac att tct aat ttc ttc tgt gac cct tct caa ctc ctc      696
 Lys Asp Val Asp Ile Ser Asn Phe Phe Cys Asp Pro Ser Gln Leu Leu
         175                 180                 185

 cac ctt agg tgt tcc gac acc ttc atc aat gaa atg gtc ata tat ttc      744
 His Leu Arg Cys Ser Asp Thr Phe Ile Asn Glu Met Val Ile Tyr Phe
     190                 195                 200

 atg ggt gcc ata ttt ggc tgt ctc cct atc tca ggg atc ctt ttc tct      792
 Met Gly Ala Ile Phe Gly Cys Leu Pro Ile Ser Gly Ile Leu Phe Ser
 205                 210                 215                 220

 tac tat aaa att gtt tcc ccc att ctg aga gtt cca aca tca gat ggg      840
 Tyr Tyr Lys Ile Val Ser Pro Ile Leu Arg Val Pro Thr Ser Asp Gly
                 225                 230                 235

 aag tat aaa gcc ttc tcc acc tgt ggc tct cac ctg gca gtt gtt tgc      888
 Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Cys
             240                 245                 250

 tta ttt tat gga aca ggg ctt gta ggg tac ctc agt tca gct gtg tta      936
 Leu Phe Tyr Gly Thr Gly Leu Val Gly Tyr Leu Ser Ser Ala Val Leu
         255                 260                 265

 cca tcc ccc agg aag agt atg gtg gct tca gtg atg tac act gtg gtc      984
 Pro Ser Pro Arg Lys Ser Met Val Ala Ser Val Met Tyr Thr Val Val
     270                 275                 280

 acc ccc atg ctg aac ccc ttc atc tac agc ctg agg aac aag gac att     1032
 Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile
 285                 290                 295                 300

 caa agt gcc ctg tgc agg ctg cat ggc aga atc atc aaa tct cat cat     1080
 Gln Ser Ala Leu Cys Arg Leu His Gly Arg Ile Ile Lys Ser His His
                 305                 310                 315

 ctc cat cct ttt tgt tat atg gga tag aaatg gcagcaaaat ttaacaccta     1132
 Leu His Pro Phe Cys Tyr Met Gly 
             320

 ggcctgcaaa ttctgcctcc ttggtcacat tattttggtt gcttgatggc tttcattcct   1192

 ctctgggttt cgtatgtg                                                 1210




      <210> 202
      <211> 1146
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1104)

      <400> 202
  atg aac cat tta ggt cac ata gct ggt ttg cac cag aat cgg aac tgc      48
  Met Asn His Leu Gly His Ile Ala Gly Leu His Gln Asn Arg Asn Cys
    1               5                  10                  15

 agt aca ggt gct gtt ggt gcc gga gct gat gtc att gcc cag tgt act       96
 Ser Thr Gly Ala Val Gly Ala Gly Ala Asp Val Ile Ala Gln Cys Thr
              20                  25                  30

 gtg ctg cct gct atg aag ctg gat ttt gat gca aat ctc tat ctg tgt      144
 Val Leu Pro Ala Met Lys Leu Asp Phe Asp Ala Asn Leu Tyr Leu Cys
          35                  40                  45

 gaa gaa gct ttt ggc ctc ctg cct ttt aat aca ttt gga agg ctt tca      192
 Glu Glu Ala Phe Gly Leu Leu Pro Phe Asn Thr Phe Gly Arg Leu Ser
      50                  55                  60

 gat act ctg ctt ttt tat gct tac ata ttc gtt ctg tcc atc aca gtg      240
 Asp Thr Leu Leu Phe Tyr Ala Tyr Ile Phe Val Leu Ser Ile Thr Val
  65                  70                  75                  80

 att gta gca ttc gtt gtt gcc ttt cat aat ctc agt gat tct aca aat      288
 Ile Val Ala Phe Val Val Ala Phe His Asn Leu Ser Asp Ser Thr Asn
                  85                  90                  95

 caa caa tcc gtg ggt aaa atg gaa aaa ggc aca gtt gac ctg aaa cca      336
 Gln Gln Ser Val Gly Lys Met Glu Lys Gly Thr Val Asp Leu Lys Pro
             100                 105                 110

 gaa act gcc tac aac tta ata cat acc att ctg ttt gga ttc ttg gca      384
 Glu Thr Ala Tyr Asn Leu Ile His Thr Ile Leu Phe Gly Phe Leu Ala
         115                 120                 125

 ttg agt aca atg aga atg aag tac ctc tgg acg tca cac atg tgt gtg      432
 Leu Ser Thr Met Arg Met Lys Tyr Leu Trp Thr Ser His Met Cys Val
     130                 135                 140

 ttc gca tca ttc ggc cta tgt agc cct gaa ata tgg gag tta ctt ctg      480
 Phe Ala Ser Phe Gly Leu Cys Ser Pro Glu Ile Trp Glu Leu Leu Leu
 145                 150                 155                 160

 aag tca gtc cat ctt tat aac cca aag agg ata tgt ata atg cga tat      528
 Lys Ser Val His Leu Tyr Asn Pro Lys Arg Ile Cys Ile Met Arg Tyr
                 165                 170                 175

 tca gta ccg ata tta ata ctg ctg tat cta tgc tat aag ttc tgg cca      576
 Ser Val Pro Ile Leu Ile Leu Leu Tyr Leu Cys Tyr Lys Phe Trp Pro
             180                 185                 190

 gga atg atg gat gaa ctc tcc gag ttg aga gaa ttc tat gat cca gat      624
 Gly Met Met Asp Glu Leu Ser Glu Leu Arg Glu Phe Tyr Asp Pro Asp
         195                 200                 205

 aca gtg gag ctg atg aac tgg att aac tct aac act cca aga aag gct      672
 Thr Val Glu Leu Met Asn Trp Ile Asn Ser Asn Thr Pro Arg Lys Ala
     210                 215                 220

 gtg ttt gcg gga agc atg cag ttg ctg gcc gga gtc aag ctg tgc acg      720
 Val Phe Ala Gly Ser Met Gln Leu Leu Ala Gly Val Lys Leu Cys Thr
 225                 230                 235                 240

 gga agg acc cta acc aac cac ccg cac tat gaa gac agc agc ctg aga      768
 Gly Arg Thr Leu Thr Asn His Pro His Tyr Glu Asp Ser Ser Leu Arg
                 245                 250                 255

 gag cgg acc aga gcg gtt tat cag ata tat gcc aag agg gca cca gag      816
 Glu Arg Thr Arg Ala Val Tyr Gln Ile Tyr Ala Lys Arg Ala Pro Glu
             260                 265                 270

 gaa gtg cat gcc ctc cta agg tcc ttc ggc act gac tac gta atc ctg      864
 Glu Val His Ala Leu Leu Arg Ser Phe Gly Thr Asp Tyr Val Ile Leu
         275                 280                 285

 gaa gac agc atc tgc tac gag cgg agg cac cgc cgg ggc tgc cga ctc      912
 Glu Asp Ser Ile Cys Tyr Glu Arg Arg His Arg Arg Gly Cys Arg Leu
     290                 295                 300

 cgg gac ctg ctg gac att gcc aac ggc cac atg atg gat ggc cca gga      960
 Arg Asp Leu Leu Asp Ile Ala Asn Gly His Met Met Asp Gly Pro Gly
 305                 310                 315                 320

 gag aat gat cct gat ttg aaa cct gca gac cac cct cgc ttc tgt gaa     1008
 Glu Asn Asp Pro Asp Leu Lys Pro Ala Asp His Pro Arg Phe Cys Glu
                 325                 330                 335

 gag atc aaa aga aac ctg cct ccc tat gtg gcc tac ttc acc aga gtg     1056
 Glu Ile Lys Arg Asn Leu Pro Pro Tyr Val Ala Tyr Phe Thr Arg Val
             340                 345                 350

 ttc cag aac aaa acc ttc cac gtt tac aag ctg tcc aga aac aag tag     1104
 Phe Gln Asn Lys Thr Phe His Val Tyr Lys Leu Ser Arg Asn Lys 
         355                 360                 365

 cgcagatttc tgcccagtgt ctatttttga tacggagaaa ct                      1146




      <210> 203
      <211> 1405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(784)

      <400> 203
 gggccggttg ctaagacttg gcgaagcgct gcgctcgcgc ccggatccct caggcggctg     60

 caggcttcag cctgcgctgg ttggtgaaac agag    atg tca gaa aag gag aac     112
                                          Met Ser Glu Lys Glu Asn
                                            1               5

 aac ttc ccg cca ctg ccc aag ttc atc cct gtg aag ccc tgc ttc tac      160
 Asn Phe Pro Pro Leu Pro Lys Phe Ile Pro Val Lys Pro Cys Phe Tyr
              10                  15                  20

 cag aac ttc tcc gac gag atc cca gtg gag cac cag gtc ctg gtg aag      208
 Gln Asn Phe Ser Asp Glu Ile Pro Val Glu His Gln Val Leu Val Lys
          25                  30                  35

 agg atc tac cgg ctg tgg atg ttt tac tgc gcc acc ctc ggc gtc aac      256
 Arg Ile Tyr Arg Leu Trp Met Phe Tyr Cys Ala Thr Leu Gly Val Asn
      40                  45                  50

 ctc att gcc tgc ctg gcc tgg tgg atc ggc gga ggc tcg ggg acc aac      304
 Leu Ile Ala Cys Leu Ala Trp Trp Ile Gly Gly Gly Ser Gly Thr Asn
  55                  60                  65                  70

 ttc ggc ctg gcc ttc gtg tgg ctg ctc ctg ttc acg cct tgc ggc tac      352
 Phe Gly Leu Ala Phe Val Trp Leu Leu Leu Phe Thr Pro Cys Gly Tyr
                  75                  80                  85

 gtg tgc tgg ttc cgg cct gtc tac aag gcc ttc cga gcc gac agc tcc      400
 Val Cys Trp Phe Arg Pro Val Tyr Lys Ala Phe Arg Ala Asp Ser Ser
              90                  95                 100

 ttt aat ttc atg gcg ttt ttc ttc atc ttc gga gcc cag ttt gtc ctg      448
 Phe Asn Phe Met Ala Phe Phe Phe Ile Phe Gly Ala Gln Phe Val Leu
         105                 110                 115

 acc gtc atc cag gcg att ggc ttc tcc ggc tgg ggc gcg tgc ggc tgg      496
 Thr Val Ile Gln Ala Ile Gly Phe Ser Gly Trp Gly Ala Cys Gly Trp
     120                 125                 130

 ctg tcg gca att gga ttc ttc cag tac agc ccg ggc gct gcc gtg gtc      544
 Leu Ser Ala Ile Gly Phe Phe Gln Tyr Ser Pro Gly Ala Ala Val Val
 135                 140                 145                 150

 atg ctg ctt cca gcc atc atg ttc tcc gtg tcg gct gcc atg atg gcc      592
 Met Leu Leu Pro Ala Ile Met Phe Ser Val Ser Ala Ala Met Met Ala
                 155                 160                 165

 atc gcg atc atg aag gtg cac agg atc tac cga ggg gct ggc gga agc      640
 Ile Ala Ile Met Lys Val His Arg Ile Tyr Arg Gly Ala Gly Gly Ser
             170                 175                 180

 ttc cag aag gca cag acg gag tgg aac acg ggc act tgg cgg aac cca      688
 Phe Gln Lys Ala Gln Thr Glu Trp Asn Thr Gly Thr Trp Arg Asn Pro
         185                 190                 195

 ccg tcg agg gag gcc cag tac aac aac ttt ctc agg caa cag cct gcc      736
 Pro Ser Arg Glu Ala Gln Tyr Asn Asn Phe Leu Arg Gln Gln Pro Ala
     200                 205                 210

 cga gta ccc cac tgt gcc cag cta ccg ggc agt ggc cag tgg cct tag      784
 Arg Val Pro His Cys Ala Gln Leu Pro Gly Ser Gly Gln Trp Pro 
 215                 220                 225

 agggagcccc ctgccaacgc acaactgcca gtggataccg gtcgaggtgg gaactaccat    844

 gggggcccca gtaaacccag ggaggggacg gaggaaggcc gggaggcggc caccacgacc    904

 cgagccgaca cctgcccagg gacacaccag aagcacggct aaaccacata cagagaacgg    964

 agatacatca ccagagaacg ggccgccaaa gcaaatgggc gtatgcacga aacaaaagaa   1024

 ccgcccgtgg agaaaccgga aaggaagggg ccaccgcaga gcagagcaac agggaggtta   1084

 ccgccgaaga ccaaggcaca tacaggacag acctaggggg cagggcaccc ccaatggaaa   1144

 cgggcaggcc gacctgcaga acgacggcag cggtgtaaga acggtaagca tgggaacacc   1204

 aacaactggg ccggcgacac gcatcataga gtgaagaccc ggtaaggcga acggcagcaa   1264

 gaacaggata taccaaaggg acccgagaca aagggggagg acctgatcaa accgcgacaa   1324

 aaggcgagca caccataggt acacagaaaa gaagagaccc agaacacaga aagttgtaga   1384

 ggaggagcgc gatgggatcg a                                             1405




      <210> 204
      <211> 2558
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(2478)

      <400> 204
 gtgctggtac agggctgcct cttggaccct tcccagcggg aggtgttcct gcagcagata     60

 tatgagcagc tctgcctctt tgaggataag gtggccacc   atg ctg cag cag cag     114
                                              Met Leu Gln Gln Gln
                                                1               5

 tac gat ccc cag agc cag gca gaa gac cag tcc cca gac tca ggg gac      162
 Tyr Asp Pro Gln Ser Gln Ala Glu Asp Gln Ser Pro Asp Ser Gly Asp
                  10                  15                  20

 tta ctg ggc cgg aag gta ggc gtc tcc atg gtg aca gct gat ctt ggg      210
 Leu Leu Gly Arg Lys Val Gly Val Ser Met Val Thr Ala Asp Leu Gly
              25                  30                  35

 ctg gtc agt atg att cgt cag ggc atc ttg gca ctg cag tta cta ccc      258
 Leu Val Ser Met Ile Arg Gln Gly Ile Leu Ala Leu Gln Leu Leu Pro
          40                  45                  50

 tcg aac tct agt gca ggg att atc gtg atc acg gat ggg gtg acc agt      306
 Ser Asn Ser Ser Ala Gly Ile Ile Val Ile Thr Asp Gly Val Thr Ser
      55                  60                  65

 gta cct gat gtt gct gtc tgt gag aca ctg ctg aac cag ctt cgc agt      354
 Val Pro Asp Val Ala Val Cys Glu Thr Leu Leu Asn Gln Leu Arg Ser
  70                  75                  80                  85

 ggc act gtg gct tgt tcc ttt gtc cag gtg gga gga gtt tac tct tat      402
 Gly Thr Val Ala Cys Ser Phe Val Gln Val Gly Gly Val Tyr Ser Tyr
                  90                  95                 100

 gac tgc agt ttt ggc cat gtg ccc aat gtg gaa tta atg aag ttc atc      450
 Asp Cys Ser Phe Gly His Val Pro Asn Val Glu Leu Met Lys Phe Ile
             105                 110                 115

 gca atg gca aca ttt ggg tcc tac ctg tcc act tgt cct gag ccg gag      498
 Ala Met Ala Thr Phe Gly Ser Tyr Leu Ser Thr Cys Pro Glu Pro Glu
         120                 125                 130

 cca ggc aac ctg ggt ctg act gtc tac cac cgg gca ttt ctc ctc tat      546
 Pro Gly Asn Leu Gly Leu Thr Val Tyr His Arg Ala Phe Leu Leu Tyr
     135                 140                 145

 tcc ttc ctg cgc agt ggg gaa gca ctg aac cct gaa tat tac tgc ggc      594
 Ser Phe Leu Arg Ser Gly Glu Ala Leu Asn Pro Glu Tyr Tyr Cys Gly
 150                 155                 160                 165

 tct cag cac cgc cta ttt aat gag cac ctg gtc tct gca agc agc aac      642
 Ser Gln His Arg Leu Phe Asn Glu His Leu Val Ser Ala Ser Ser Asn
                 170                 175                 180

 cct gcc ctg gcc ttg cgc cgg aag aag cac act gag aag gag gtg cca      690
 Pro Ala Leu Ala Leu Arg Arg Lys Lys His Thr Glu Lys Glu Val Pro
             185                 190                 195

 gcc gac ttg gtc agc act gtg tcc gta cgg ctt cga gag ggc tac agt      738
 Ala Asp Leu Val Ser Thr Val Ser Val Arg Leu Arg Glu Gly Tyr Ser
         200                 205                 210

 gtc cga gag gtc aca ctg gcc aaa gga ggg tcc caa ttg gag gta aag      786
 Val Arg Glu Val Thr Leu Ala Lys Gly Gly Ser Gln Leu Glu Val Lys
     215                 220                 225

 ctg gtg ctg ctg tgg aaa cac aac atg cgc att gag tat gtg gct atg      834
 Leu Val Leu Leu Trp Lys His Asn Met Arg Ile Glu Tyr Val Ala Met
 230                 235                 240                 245

 gca ccc tgg ccc ctg gag cct gag ggc cct cga gta aca cgg gtg gaa      882
 Ala Pro Trp Pro Leu Glu Pro Glu Gly Pro Arg Val Thr Arg Val Glu
                 250                 255                 260

 gtg acg atg gaa ggc ggc tac gac att ttg cat gat gtg tcc tgt gca      930
 Val Thr Met Glu Gly Gly Tyr Asp Ile Leu His Asp Val Ser Cys Ala
             265                 270                 275

 cta agg cag ccc att cgt tca ttg tat cgt acc cat gtt atc cgg cgt      978
 Leu Arg Gln Pro Ile Arg Ser Leu Tyr Arg Thr His Val Ile Arg Arg
         280                 285                 290

 ttc tgg aac acg ctg cag agc atc aac cag aca gac cag atg ctt gcc     1026
 Phe Trp Asn Thr Leu Gln Ser Ile Asn Gln Thr Asp Gln Met Leu Ala
     295                 300                 305

 cac ctt cag tcc ttc tcc tca gtg cct gag cat ttc acg ctt cct gac     1074
 His Leu Gln Ser Phe Ser Ser Val Pro Glu His Phe Thr Leu Pro Asp
 310                 315                 320                 325

 agc acc aag agc gga gtg cca ctc ttc tac atc cct cca ggc tcc acc     1122
 Ser Thr Lys Ser Gly Val Pro Leu Phe Tyr Ile Pro Pro Gly Ser Thr
                 330                 335                 340

 acc ccg gtg ctc tcc ctc cag ccc agt ggt tct gac tca tcc cat gcc     1170
 Thr Pro Val Leu Ser Leu Gln Pro Ser Gly Ser Asp Ser Ser His Ala
             345                 350                 355

 cag ttt gct gcc tac tgg aag cca gtg ctg tcc atg gat gca aat tcc     1218
 Gln Phe Ala Ala Tyr Trp Lys Pro Val Leu Ser Met Asp Ala Asn Ser
         360                 365                 370

 tgg cag cga tgg ctg cac atg cat cgc ctg gtg cta atc ctg gag cat     1266
 Trp Gln Arg Trp Leu His Met His Arg Leu Val Leu Ile Leu Glu His
     375                 380                 385

 gac aca cca atc ccc aag cac ttg cac acc ccg ggc agc aat ggg cgc     1314
 Asp Thr Pro Ile Pro Lys His Leu His Thr Pro Gly Ser Asn Gly Arg
 390                 395                 400                 405

 tac agc act atc cag tgc agg atc tcc cac tcc tcc ctg acc tct ctg     1362
 Tyr Ser Thr Ile Gln Cys Arg Ile Ser His Ser Ser Leu Thr Ser Leu
                 410                 415                 420

 ctg cgg gac tgg agc agc ttc gta cta gtc gag ggc tat tct tat gtt     1410
 Leu Arg Asp Trp Ser Ser Phe Val Leu Val Glu Gly Tyr Ser Tyr Val
             425                 430                 435

 aag ctg ctc tcc agt gcc cca gac cag ccc ccc aat tcc ttc tac atg     1458
 Lys Leu Leu Ser Ser Ala Pro Asp Gln Pro Pro Asn Ser Phe Tyr Met
         440                 445                 450

 gtc cgt atc att tcc aag gcc cca tgc atg gtt ctt cgc ctg ggt ttt     1506
 Val Arg Ile Ile Ser Lys Ala Pro Cys Met Val Leu Arg Leu Gly Phe
     455                 460                 465

 ccc att ggc aca cca gca ccg gcc cgg cac aag att gtg tca ggc ttg     1554
 Pro Ile Gly Thr Pro Ala Pro Ala Arg His Lys Ile Val Ser Gly Leu
 470                 475                 480                 485

 agg gaa gag atc ctg cgg ctg cgt ttc ccc cac cgg gta caa agc aag     1602
 Arg Glu Glu Ile Leu Arg Leu Arg Phe Pro His Arg Val Gln Ser Lys
                 490                 495                 500

 gag cca acg ccc aag gtg aaa cga aaa ggg cta ggg ggt gct ggt ggg     1650
 Glu Pro Thr Pro Lys Val Lys Arg Lys Gly Leu Gly Gly Ala Gly Gly
             505                 510                 515

 ggc agc tct ccc tcc aag tca ccc ccc gtg ctg ggg cca cag cag gcc     1698
 Gly Ser Ser Pro Ser Lys Ser Pro Pro Val Leu Gly Pro Gln Gln Ala
         520                 525                 530

 ctg tct gac cgg ccc tgc ctt gtg gtc ctg cat aag cca ctg gac aaa     1746
 Leu Ser Asp Arg Pro Cys Leu Val Val Leu His Lys Pro Leu Asp Lys
     535                 540                 545

 ctg ctc atc agg ttg gta cag agg tat gag aag ctg ccc ttg gac tac     1794
 Leu Leu Ile Arg Leu Val Gln Arg Tyr Glu Lys Leu Pro Leu Asp Tyr
 550                 555                 560                 565

 cgg gca ccc ttc ttg ctg aca ttg gag cca cca ggt cca ctg ccc ttg     1842
 Arg Ala Pro Phe Leu Leu Thr Leu Glu Pro Pro Gly Pro Leu Pro Leu
                 570                 575                 580

 gtg tca ggc cgc tca gcc tct tct agc ctg gcg tca ctg tcc cgc tac     1890
 Val Ser Gly Arg Ser Ala Ser Ser Ser Leu Ala Ser Leu Ser Arg Tyr
             585                 590                 595

 ctc tac cat cag cgc tgg ctt tgg agt gtc ccg tca gga ctg gcc cct     1938
 Leu Tyr His Gln Arg Trp Leu Trp Ser Val Pro Ser Gly Leu Ala Pro
         600                 605                 610

 gcg ctg cct ctc agt gcc att gcc cag ctc ctc tcc atc ctc act gat     1986
 Ala Leu Pro Leu Ser Ala Ile Ala Gln Leu Leu Ser Ile Leu Thr Asp
     615                 620                 625

 ggg gaa gga atc atc aac atg gtt ctg gag ctt cca att cag aat gaa     2034
 Gly Glu Gly Ile Ile Asn Met Val Leu Glu Leu Pro Ile Gln Asn Glu
 630                 635                 640                 645

 cca cca ggg cag gct gca gct gaa gag aag cac acc tgt gtt gtc cag     2082
 Pro Pro Gly Gln Ala Ala Ala Glu Glu Lys His Thr Cys Val Val Gln
                 650                 655                 660

 tac atc ctc ttc ccc cca cac tct acc tcc acc aaa gac agc ttc tcg     2130
 Tyr Ile Leu Phe Pro Pro His Ser Thr Ser Thr Lys Asp Ser Phe Ser
             665                 670                 675

 aca gat gat gac aat gat gtg gaa gtg gag gcc ctg gag gga gac tca     2178
 Thr Asp Asp Asp Asn Asp Val Glu Val Glu Ala Leu Glu Gly Asp Ser
         680                 685                 690

 gag ctc aat ctg gtc act gag gtg tgg gtg gag cca cag tat ggg cga     2226
 Glu Leu Asn Leu Val Thr Glu Val Trp Val Glu Pro Gln Tyr Gly Arg
     695                 700                 705

 gtg gga cct ggc cct gga atc tgg aag cac ctc cag gac ctg acg tat     2274
 Val Gly Pro Gly Pro Gly Ile Trp Lys His Leu Gln Asp Leu Thr Tyr
 710                 715                 720                 725

 tct gag atc ccg caa gct ctc cac cca cgg gat gct gcc tgc ata ggc     2322
 Ser Glu Ile Pro Gln Ala Leu His Pro Arg Asp Ala Ala Cys Ile Gly
                 730                 735                 740

 tcc atg ctg agc ttt gaa tac ctg ata cag ctg tgt cag agc aag gaa     2370
 Ser Met Leu Ser Phe Glu Tyr Leu Ile Gln Leu Cys Gln Ser Lys Glu
             745                 750                 755

 tgg ggt cct ctg ccc cca gag ccg agg gtc tct gat ggt gag tgg ggc     2418
 Trp Gly Pro Leu Pro Pro Glu Pro Arg Val Ser Asp Gly Glu Trp Gly
         760                 765                 770

 agg cgg ccc act ggt gga gca ggg gag att gga tca ggg agg aga cac     2466
 Arg Arg Pro Thr Gly Gly Ala Gly Glu Ile Gly Ser Gly Arg Arg His
     775                 780                 785

 ctg cgt cca tga gat ccctttccat tttgacctaa tgggattgct gccacagtgc     2521
 Leu Arg Pro 
 790

 cagcagctcc agatgttctt cctcttgctt gccagag                            2558




      <210> 205
      <211> 3258
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(2974)

      <400> 205
 tctgagattc tgtgcaagcc tc atg gaa atg aag ctg cca ggc cag gaa ggg      52
                          Met Glu Met Lys Leu Pro Gly Gln Glu Gly
                            1               5                  10

 ttt gaa gcc tcc agt gct cct aga aat att cct tca ggg gag ctg gac      100
 Phe Glu Ala Ser Ser Ala Pro Arg Asn Ile Pro Ser Gly Glu Leu Asp
                  15                  20                  25

 agc aac cct gac cct ggc acc ggc ccc agc cct gat ggc ccc tca gac      148
 Ser Asn Pro Asp Pro Gly Thr Gly Pro Ser Pro Asp Gly Pro Ser Asp
              30                  35                  40

 aca gag agc aag gaa ctg gga gta ccc aaa gac cct ctg ctc ttc att      196
 Thr Glu Ser Lys Glu Leu Gly Val Pro Lys Asp Pro Leu Leu Phe Ile
          45                  50                  55

 cag ctg aat gag ctg ctg ggc tgg ccc cag gcg ctg gag tgg aga gag      244
 Gln Leu Asn Glu Leu Leu Gly Trp Pro Gln Ala Leu Glu Trp Arg Glu
      60                  65                  70

 aca ggc agc tcc tct gca tct ctg ctc ctg gac atg gga gaa atg ccc      292
 Thr Gly Ser Ser Ser Ala Ser Leu Leu Leu Asp Met Gly Glu Met Pro
  75                  80                  85                  90

 tca ata aca ctg tct acc cac ctt cat cac agg tgg gta ctg ttt gag      340
 Ser Ile Thr Leu Ser Thr His Leu His His Arg Trp Val Leu Phe Glu
                  95                 100                 105

 gag aag ttg gag gtg gct gca ggc cgg tgg agt gcc ccc cac gtg ccc      388
 Glu Lys Leu Glu Val Ala Ala Gly Arg Trp Ser Ala Pro His Val Pro
             110                 115                 120

 acc ctg gca ctg ccc agc ctc cag aag ctc cgc agc ctg ctg gcc gag      436
 Thr Leu Ala Leu Pro Ser Leu Gln Lys Leu Arg Ser Leu Leu Ala Glu
         125                 130                 135

 ggc ctt gta ctg ctg gac tgc cca gct cag agc ctc ctg gag ctc gtg      484
 Gly Leu Val Leu Leu Asp Cys Pro Ala Gln Ser Leu Leu Glu Leu Val
     140                 145                 150

 gag cag gtg acc agg gtg gag tcg ctg agc cca gag ctg aga ggg cag      532
 Glu Gln Val Thr Arg Val Glu Ser Leu Ser Pro Glu Leu Arg Gly Gln
 155                 160                 165                 170

 ttg cag gcc ttg ctg ctg cag aga ccc cag cat tac aac cag acc aca      580
 Leu Gln Ala Leu Leu Leu Gln Arg Pro Gln His Tyr Asn Gln Thr Thr
                 175                 180                 185

 ggc acc agg ccc tgc tgg ggc tct act cat cca aga aag gct tct gac      628
 Gly Thr Arg Pro Cys Trp Gly Ser Thr His Pro Arg Lys Ala Ser Asp
             190                 195                 200

 aat gag gaa gcc ccc ctg agg gaa cag tgt cag aac ccc ctg aga cag      676
 Asn Glu Glu Ala Pro Leu Arg Glu Gln Cys Gln Asn Pro Leu Arg Gln
         205                 210                 215

 aag cta cct cca gga gct gag gca ggg act gtg ctg gca ggg gag ctg      724
 Lys Leu Pro Pro Gly Ala Glu Ala Gly Thr Val Leu Ala Gly Glu Leu
     220                 225                 230

 ggc ttc ctg gca cag cca ctg gga gcc ttt gtt cga ctg cgg aac cct      772
 Gly Phe Leu Ala Gln Pro Leu Gly Ala Phe Val Arg Leu Arg Asn Pro
 235                 240                 245                 250

 gtg gta ctg ggg tcc ctt act gag gtg tcc ctc cca agc agg ttt ttc      820
 Val Val Leu Gly Ser Leu Thr Glu Val Ser Leu Pro Ser Arg Phe Phe
                 255                 260                 265

 tgc ctt ctc ctg ggc ccc tgt atg ctg gga aag ggc tac cat gag atg      868
 Cys Leu Leu Leu Gly Pro Cys Met Leu Gly Lys Gly Tyr His Glu Met
             270                 275                 280

 gga cgg gca gca gct gtc ctc ctc agt gac ccg caa ttc cag tgg tca      916
 Gly Arg Ala Ala Ala Val Leu Leu Ser Asp Pro Gln Phe Gln Trp Ser
         285                 290                 295

 gtt cgt cgg gcc agc aac ctt cat gac ctt ctg gca gcc ctg gat gca      964
 Val Arg Arg Ala Ser Asn Leu His Asp Leu Leu Ala Ala Leu Asp Ala
     300                 305                 310

 ttc cta gag gag gtg aca gtg ctt ccc cca ggt cgg tgg gac cca aca     1012
 Phe Leu Glu Glu Val Thr Val Leu Pro Pro Gly Arg Trp Asp Pro Thr
 315                 320                 325                 330

 gcc cgg att ccc ccg ccc aaa tgt ctg cca tct cag cac aaa agg ctt     1060
 Ala Arg Ile Pro Pro Pro Lys Cys Leu Pro Ser Gln His Lys Arg Leu
                 335                 340                 345

 ccc tcg caa cag cgg gag atc aga ggt ccc gcc gtc ccg cgc ctg acc     1108
 Pro Ser Gln Gln Arg Glu Ile Arg Gly Pro Ala Val Pro Arg Leu Thr
             350                 355                 360

 tcg gct gag gac agg cac cgc cat ggg cca cac gca cac agc ccg gag     1156
 Ser Ala Glu Asp Arg His Arg His Gly Pro His Ala His Ser Pro Glu
         365                 370                 375

 ttg cag cgg acc ggc agg ctg ttt ggg ggc ctt atc cag gac gtg cgc     1204
 Leu Gln Arg Thr Gly Arg Leu Phe Gly Gly Leu Ile Gln Asp Val Arg
     380                 385                 390

 agg aag gtc ccg tgg tac ccc agc gat ttc ttg gac gcc ctg cat ctc     1252
 Arg Lys Val Pro Trp Tyr Pro Ser Asp Phe Leu Asp Ala Leu His Leu
 395                 400                 405                 410

 cag tgc ttc tcg gcc gta ctc tac att tac ctg gcc act gtc act aat     1300
 Gln Cys Phe Ser Ala Val Leu Tyr Ile Tyr Leu Ala Thr Val Thr Asn
                 415                 420                 425

 gcc atc act ttt ggg ggt ctg ctg gga gat gcc act gat ggt gcc cag     1348
 Ala Ile Thr Phe Gly Gly Leu Leu Gly Asp Ala Thr Asp Gly Ala Gln
             430                 435                 440

 gga gtg ctg gaa agt ttc ctg ggc aca gca gtg gct gga gct gcc ttc     1396
 Gly Val Leu Glu Ser Phe Leu Gly Thr Ala Val Ala Gly Ala Ala Phe
         445                 450                 455

 tgc ctg atg gca ggc cag ccc ctc acc att ctg agc agc acg ggg cca     1444
 Cys Leu Met Ala Gly Gln Pro Leu Thr Ile Leu Ser Ser Thr Gly Pro
     460                 465                 470

 gtg ctg gtc ttt gag cgc ctg ctc ttc tct ttc agc aga gat tac agc     1492
 Val Leu Val Phe Glu Arg Leu Leu Phe Ser Phe Ser Arg Asp Tyr Ser
 475                 480                 485                 490

 ctg gac tac ctg ccc ttc cgc cta tgg gtg ggc atc tgg gtg gct acc     1540
 Leu Asp Tyr Leu Pro Phe Arg Leu Trp Val Gly Ile Trp Val Ala Thr
                 495                 500                 505

 ttt tgc ctg gtg ctg gtg gcc aca gag gcc agt gtg ctg gtg cgc tac     1588
 Phe Cys Leu Val Leu Val Ala Thr Glu Ala Ser Val Leu Val Arg Tyr
             510                 515                 520

 ttc acc cgc ttc act gag gaa ggt ttc tgt gcc ctc atc agc ctc atc     1636
 Phe Thr Arg Phe Thr Glu Glu Gly Phe Cys Ala Leu Ile Ser Leu Ile
         525                 530                 535

 ttc atc tac gat gct gtg ggc aaa atg ctg aac ttg acc cat acc tat     1684
 Phe Ile Tyr Asp Ala Val Gly Lys Met Leu Asn Leu Thr His Thr Tyr
     540                 545                 550

 cct atc cag aag cct ggg tcc tct gcc tac ggg tgc ctc tgc caa tac     1732
 Pro Ile Gln Lys Pro Gly Ser Ser Ala Tyr Gly Cys Leu Cys Gln Tyr
 555                 560                 565                 570

 cca ggc cca gga gga aat gag tct caa tgg ata agg aca agg cca aaa     1780
 Pro Gly Pro Gly Gly Asn Glu Ser Gln Trp Ile Arg Thr Arg Pro Lys
                 575                 580                 585

 gac aga gac gac att gta agc atg gac tta ggc ctg atc aat gca tcc     1828
 Asp Arg Asp Asp Ile Val Ser Met Asp Leu Gly Leu Ile Asn Ala Ser
             590                 595                 600

 ttg ctg ccg cca cct gag tgc acc cgg cag gga ggc cac cct cgt ggc     1876
 Leu Leu Pro Pro Pro Glu Cys Thr Arg Gln Gly Gly His Pro Arg Gly
         605                 610                 615

 cct ggc tgt cat aca gtc cca gac att gcc ttc ttc tcc ctt ctc ctc     1924
 Pro Gly Cys His Thr Val Pro Asp Ile Ala Phe Phe Ser Leu Leu Leu
     620                 625                 630

 ttc ctt act tct ttc ttc ttt gct atg gcc ctc aag tgt gta aag acc     1972
 Phe Leu Thr Ser Phe Phe Phe Ala Met Ala Leu Lys Cys Val Lys Thr
 635                 640                 645                 650

 agc cgc ttc ttc ccc tct gtg gtg cgc aaa ggg ctc agc gac ttc tcc     2020
 Ser Arg Phe Phe Pro Ser Val Val Arg Lys Gly Leu Ser Asp Phe Ser
                 655                 660                 665

 tca gtc ctg gcc atc ctg ctc ggc tgt ggc ctt gat gct ttc ctg ggc     2068
 Ser Val Leu Ala Ile Leu Leu Gly Cys Gly Leu Asp Ala Phe Leu Gly
             670                 675                 680

 cta gcc aca cca aag ctc atg gta ccc aga gag ttc aag ccc aca ctc     2116
 Leu Ala Thr Pro Lys Leu Met Val Pro Arg Glu Phe Lys Pro Thr Leu
         685                 690                 695

 cct ggg cgt ggc tgg ctg gtg tca cct ttt gga gcc aac ccc tgg tgg     2164
 Pro Gly Arg Gly Trp Leu Val Ser Pro Phe Gly Ala Asn Pro Trp Trp
     700                 705                 710

 tgg agt gtg gca gct gcc ctg cct gcc ctg ctg ctg tct atc ctc atc     2212
 Trp Ser Val Ala Ala Ala Leu Pro Ala Leu Leu Leu Ser Ile Leu Ile
 715                 720                 725                 730

 ttc atg gac caa cag atc aca gca gtc atc ctc aac cgc atg gaa tac     2260
 Phe Met Asp Gln Gln Ile Thr Ala Val Ile Leu Asn Arg Met Glu Tyr
                 735                 740                 745

 aga ctg cag aag gga gct ggc ttc cac ctg gac ctc ttc tgt gtg gct     2308
 Arg Leu Gln Lys Gly Ala Gly Phe His Leu Asp Leu Phe Cys Val Ala
             750                 755                 760

 gtg ctg atg cta ctc aca tca gcg ctt gga ctg cct tgg tat gtc tca     2356
 Val Leu Met Leu Leu Thr Ser Ala Leu Gly Leu Pro Trp Tyr Val Ser
         765                 770                 775

 gcc act gtc atc tcc ctg gct cac atg gac agt ctt cgg aga gag agc     2404
 Ala Thr Val Ile Ser Leu Ala His Met Asp Ser Leu Arg Arg Glu Ser
     780                 785                 790

 aga gcc tgt gcc ccc ggg gag cgc ccc aac ttc ctg ggt atc agg gaa     2452
 Arg Ala Cys Ala Pro Gly Glu Arg Pro Asn Phe Leu Gly Ile Arg Glu
 795                 800                 805                 810

 cag agg ctg aca ggc ctg gtg gtg ttc atc ctt aca gga gcc tcc atc     2500
 Gln Arg Leu Thr Gly Leu Val Val Phe Ile Leu Thr Gly Ala Ser Ile
                 815                 820                 825

 ttc ctg gca cct gtg ctc aag ttc att cca atg cct gtg ctc tat ggc     2548
 Phe Leu Ala Pro Val Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly
             830                 835                 840

 atc ttc ctg tat atg ggg gtg gca gcg ctc agc agc att cag ttc act     2596
 Ile Phe Leu Tyr Met Gly Val Ala Ala Leu Ser Ser Ile Gln Phe Thr
         845                 850                 855

 aat agg gtg aag ctg ttg ttg atg cca gca aaa cac cag cca gac ctg     2644
 Asn Arg Val Lys Leu Leu Leu Met Pro Ala Lys His Gln Pro Asp Leu
     860                 865                 870

 cta ctc ttg cgg cat gtg cct ctg acc agg gtc cac ctc ttc aca gcc     2692
 Leu Leu Leu Arg His Val Pro Leu Thr Arg Val His Leu Phe Thr Ala
 875                 880                 885                 890

 atc cag ctt gcc tgt ctg ggg ctg ctt tgg ata atc aag tct acc cct     2740
 Ile Gln Leu Ala Cys Leu Gly Leu Leu Trp Ile Ile Lys Ser Thr Pro
                 895                 900                 905

 gca gcc atc atc ttc ccc ctc atg ttg ctg ggc ctt gtg ggg gtc cga     2788
 Ala Ala Ile Ile Phe Pro Leu Met Leu Leu Gly Leu Val Gly Val Arg
             910                 915                 920

 aag gcc ctg gag agg gtc ttc tca cca cag gaa ctc ctc tgg ctg gat     2836
 Lys Ala Leu Glu Arg Val Phe Ser Pro Gln Glu Leu Leu Trp Leu Asp
         925                 930                 935

 gag ctg atg cca gag gag gag aga agc atc cct gag aag ggg ctg gag     2884
 Glu Leu Met Pro Glu Glu Glu Arg Ser Ile Pro Glu Lys Gly Leu Glu
     940                 945                 950

 cca gaa cac tca ttc agt gga agt gac agt gaa gat tca gag ctg atg     2932
 Pro Glu His Ser Phe Ser Gly Ser Asp Ser Glu Asp Ser Glu Leu Met
 955                 960                 965                 970

 tat cag cca aag gct cca gaa atc aac att tct gtg aat tag ctggagt     2981
 Tyr Gln Pro Lys Ala Pro Glu Ile Asn Ile Ser Val Asn 
                 975                 980

 aggagtctgg gagtggagac cccaggaaac agcatgagtt cacaggtgct tactcaggaa   3041

 gtcaggacat ttttggcctt tggcttaact tccagatgct cagtcggctt ggggaaggac   3101

 tgaagggcag ctgccaagac ctcagttacc tcctgacctg agggtggaga gtggcaggaa   3161

 gcaagcatgt ttgctgtgca cttaggaaag gctggtgagc cagagggact gatcaggccc   3221

 cattcactct ctactcatta aaaggtcctg agccacg                            3258




      <210> 206
      <211> 1869
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1869)

      <400> 206
  atg gat gag ctg ctt ctc cat act gag cct cag ttc tct tgt ctg cag      48
  Met Asp Glu Leu Leu Leu His Thr Glu Pro Gln Phe Ser Cys Leu Gln
    1               5                  10                  15

 aat ggg gcc aca gtc cct ttc ctg cta ccc tcc ctc ctg aat gtg aca       96
 Asn Gly Ala Thr Val Pro Phe Leu Leu Pro Ser Leu Leu Asn Val Thr
              20                  25                  30

 cag ctg aga ctg ccc ttt ggg agc tct tct gta gtc ttt gca cac ttc      144
 Gln Leu Arg Leu Pro Phe Gly Ser Ser Ser Val Val Phe Ala His Phe
          35                  40                  45

 ttc ctg gag ata gaa ggg ttt gaa ccc aac ccc aca gtt gcc aag acc      192
 Phe Leu Glu Ile Glu Gly Phe Glu Pro Asn Pro Thr Val Ala Lys Thr
      50                  55                  60

 tct cct cct gtc ttc tcc aag ccc atg gat tcc aac atc cgg cag tgc      240
 Ser Pro Pro Val Phe Ser Lys Pro Met Asp Ser Asn Ile Arg Gln Cys
  65                  70                  75                  80

 atc tct ggt aac tgt gat gac atg gac tcc ccc cag tct cct cag gat      288
 Ile Ser Gly Asn Cys Asp Asp Met Asp Ser Pro Gln Ser Pro Gln Asp
                  85                  90                  95

 gat gtg aca gag acc cca tcc aat ccc aac agc ccc agt gca cag ctg      336
 Asp Val Thr Glu Thr Pro Ser Asn Pro Asn Ser Pro Ser Ala Gln Leu
             100                 105                 110

 gcc aag gaa gag cag agg agg aaa aag agg cgg ctg aag aag cgc atc      384
 Ala Lys Glu Glu Gln Arg Arg Lys Lys Arg Arg Leu Lys Lys Arg Ile
         115                 120                 125

 ttt gca gcc gtg tct gag ggc tgc gtg gag gag ttg gta gag ttg ctg      432
 Phe Ala Ala Val Ser Glu Gly Cys Val Glu Glu Leu Val Glu Leu Leu
     130                 135                 140

 gtg gag ctg cag gag ctt tgc agg cgg cgc cat gat gag gat gtg cct      480
 Val Glu Leu Gln Glu Leu Cys Arg Arg Arg His Asp Glu Asp Val Pro
 145                 150                 155                 160

 gac ttc ctc atg cac aag ctg acg gcc tcc gac acg ggg aag acc tgc      528
 Asp Phe Leu Met His Lys Leu Thr Ala Ser Asp Thr Gly Lys Thr Cys
                 165                 170                 175

 ctg atg aag gcc ttg tta aac atc aac ccc aac acc aag gag ata gtg      576
 Leu Met Lys Ala Leu Leu Asn Ile Asn Pro Asn Thr Lys Glu Ile Val
             180                 185                 190

 cgg atc ctg ctt gcc ttt gct gaa gag aac gac atc ctg ggc agg ttc      624
 Arg Ile Leu Leu Ala Phe Ala Glu Glu Asn Asp Ile Leu Gly Arg Phe
         195                 200                 205

 atc aac gcc gag tac aca gag gag gcc tat gaa ggg cag acg gcg ctg      672
 Ile Asn Ala Glu Tyr Thr Glu Glu Ala Tyr Glu Gly Gln Thr Ala Leu
     210                 215                 220

 aac atc gcc atc gag cgg cgg cag ggg gac atc gca gcc ctg ctc atc      720
 Asn Ile Ala Ile Glu Arg Arg Gln Gly Asp Ile Ala Ala Leu Leu Ile
 225                 230                 235                 240

 gcc gcc ggc gcc gac gtc aac gcg cac gcc aag ggg gcc ttc ttc aac      768
 Ala Ala Gly Ala Asp Val Asn Ala His Ala Lys Gly Ala Phe Phe Asn
                 245                 250                 255

 ccc aag tac caa cac gaa ggc ttc tac ttc ggt gag acg ccc ctg gcc      816
 Pro Lys Tyr Gln His Glu Gly Phe Tyr Phe Gly Glu Thr Pro Leu Ala
             260                 265                 270

 ctg gca gca tgc acc aac cag ccc gag att gtg cag ctg ctg atg gag      864
 Leu Ala Ala Cys Thr Asn Gln Pro Glu Ile Val Gln Leu Leu Met Glu
         275                 280                 285

 cac gag cag acg gac atc acc tcg cgg gac tca cga ggc aac aac atc      912
 His Glu Gln Thr Asp Ile Thr Ser Arg Asp Ser Arg Gly Asn Asn Ile
     290                 295                 300

 ctt cac gcc ctg gtg acc gtg gcc gag gac ttc aag acg cag aat gac      960
 Leu His Ala Leu Val Thr Val Ala Glu Asp Phe Lys Thr Gln Asn Asp
 305                 310                 315                 320

 ttt gtg aag cgc atg tac gac atg atc cta ctg cgg agt ggc aac tgg     1008
 Phe Val Lys Arg Met Tyr Asp Met Ile Leu Leu Arg Ser Gly Asn Trp
                 325                 330                 335

 gag ctg gag acc act cgc aac aac gat ggc ctc acg ccg ctg cag ctg     1056
 Glu Leu Glu Thr Thr Arg Asn Asn Asp Gly Leu Thr Pro Leu Gln Leu
             340                 345                 350

 gcc gcc aag atg ggc aag gcg gag atc ctg aag tac atc ctc agt cgt     1104
 Ala Ala Lys Met Gly Lys Ala Glu Ile Leu Lys Tyr Ile Leu Ser Arg
         355                 360                 365

 gag atc aag gag aag cgg ctc cgg agc ctg tcc agg aag ttc acc gac     1152
 Glu Ile Lys Glu Lys Arg Leu Arg Ser Leu Ser Arg Lys Phe Thr Asp
     370                 375                 380

 tgg gcg tac gga ccc gtg tca tcc tcc ctc tac gac ctc acc aac gtg     1200
 Trp Ala Tyr Gly Pro Val Ser Ser Ser Leu Tyr Asp Leu Thr Asn Val
 385                 390                 395                 400

 gac acc acc acg gac aac tca gtg ctg gaa atc act gtc tac aac acc     1248
 Asp Thr Thr Thr Asp Asn Ser Val Leu Glu Ile Thr Val Tyr Asn Thr
                 405                 410                 415

 aac atc gac aac cgg cat gag atg ctg acc ctg gag ccg ctg cac acg     1296
 Asn Ile Asp Asn Arg His Glu Met Leu Thr Leu Glu Pro Leu His Thr
             420                 425                 430

 ctg ctg cat atg aag tgg aag aag ttt gcc aag cac atg ttc ctt ctg     1344
 Leu Leu His Met Lys Trp Lys Lys Phe Ala Lys His Met Phe Leu Leu
         435                 440                 445

 tcc ttc tgc ttt tat ttc ttc tac aac atc acc ctg acc ctc gtc tcg     1392
 Ser Phe Cys Phe Tyr Phe Phe Tyr Asn Ile Thr Leu Thr Leu Val Ser
     450                 455                 460

 tac tac cgc ccc cgg gag gag gag gcc atc ccg cac ccc ttg gcc ctg     1440
 Tyr Tyr Arg Pro Arg Glu Glu Glu Ala Ile Pro His Pro Leu Ala Leu
 465                 470                 475                 480

 acg cac aag atg ggg tgg ctg cag ctc cta ggg agg atg ttt gtg ctc     1488
 Thr His Lys Met Gly Trp Leu Gln Leu Leu Gly Arg Met Phe Val Leu
                 485                 490                 495

 atc tgg gcc atg tgc atc tct gtg aaa gag ggc att gcc atc ttc ctg     1536
 Ile Trp Ala Met Cys Ile Ser Val Lys Glu Gly Ile Ala Ile Phe Leu
             500                 505                 510

 ctg aga ccc tcg gat ctg cag tcc atc ctc tcg gat gcc tgg ttc cac     1584
 Leu Arg Pro Ser Asp Leu Gln Ser Ile Leu Ser Asp Ala Trp Phe His
         515                 520                 525

 ttt gtc ttt ttt atc caa gct gtg ctt gtg ata ctg tct gtc ttc ttg     1632
 Phe Val Phe Phe Ile Gln Ala Val Leu Val Ile Leu Ser Val Phe Leu
     530                 535                 540

 tac ttg ttt gcc tac aaa gag tac ctc gcc tgc ctc gtg ctg gcc atg     1680
 Tyr Leu Phe Ala Tyr Lys Glu Tyr Leu Ala Cys Leu Val Leu Ala Met
 545                 550                 555                 560

 gcc ctg ggc tgg gcg aac atg ctc tac tat acg cgg ggt ttc cag tcc     1728
 Ala Leu Gly Trp Ala Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln Ser
                 565                 570                 575

 atg ggc atg tac agc gtc atg atc cag aag ggc caa ttt cca gct acc     1776
 Met Gly Met Tyr Ser Val Met Ile Gln Lys Gly Gln Phe Pro Ala Thr
             580                 585                 590

 aac att atg tta ctg gac ata gag tta ggg aga aac atg cag atc cac     1824
 Asn Ile Met Leu Leu Asp Ile Glu Leu Gly Arg Asn Met Gln Ile His
         595                 600                 605

 atc gct cta gaa ttc ctg cca tat ggc tat gat aga gac aag taa         1869
 Ile Ala Leu Glu Phe Leu Pro Tyr Gly Tyr Asp Arg Asp Lys 
     610                 615                 620





      <210> 207
      <211> 1623
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (767)..(1426)

      <400> 207
 ttctgcacag gctcccactg ccctggctcc tgtacaccgt cattcacaga ttccagccag     60

 tggctgtcag cagcaatggc cttttctgtg ccatcgtcct tctcttcatc atgctgctct    120

 tcgtcatcct ctctatcgcc ctctgcaagt ggcgaatgaa caaaatcctg ggcttcatca    180

 tgtttggcct ctactttgtg ttcctggtgg tgagcgttct ctcctggacc aatgaacgtt    240

 agccacagag tcaggtcaca gtgtatacca tggttgttct tatggtagcc atcttttttt    300

 ttctgccatg taaatgtcat ctgccccata tcacactttg ccccaacctg gccttctccc    360

 tcttcatttc cttcttcaat gccacctcca ttttcccaga gtgttttttg gtttctgaaa    420

 ggctttctag cttcctggtt ccaaagagtc tgtggccaca gtatcacctg caccacaccc    480

 acacagctga taatcagctt atttaccaaa gtttccctgg gaacaaggac cttctcatga    540

 agagagaggg tgggtgccct cttggagagg ttgtttgcta tttgctccct cacaggggta    600

 acctcccatt gccagtcctg tgccctctgg tcctctctag gtctctctga ctgctcctgc    660

 tccttgtcag ccaggacctg tgtctcctca taactcaggc ttctgtaaat cagctctggg    720

 ctcttctcag ctgcgcgagc agctgctcca atgccccgga gtggcc   atg ggc gcc     775
                                                      Met Gly Ala
                                                        1

 ccg cac tgg tgg gac cag ctg cag gct ggt agc tcg gag gtg gac tgg      823
 Pro His Trp Trp Asp Gln Leu Gln Ala Gly Ser Ser Glu Val Asp Trp
       5                  10                  15

 tgc gag gac aac tac acc atc gtg cct gct atc gcc gag ttc tac aac      871
 Cys Glu Asp Asn Tyr Thr Ile Val Pro Ala Ile Ala Glu Phe Tyr Asn
  20                  25                  30                  35

 acg atc agc aat gtc tta ttt ttc att tta ccg ccc atc tgc atg tgc      919
 Thr Ile Ser Asn Val Leu Phe Phe Ile Leu Pro Pro Ile Cys Met Cys
                  40                  45                  50

 ttg ttt cgt caa agg tat cta cca aag atc ttt cgg aat gac cag ggt      967
 Leu Phe Arg Gln Arg Tyr Leu Pro Lys Ile Phe Arg Asn Asp Gln Gly
              55                  60                  65

 agg ttc aag gtg gtg gtc tgt gtc ctg tct gca gtt atg acg tgc ctg     1015
 Arg Phe Lys Val Val Val Cys Val Leu Ser Ala Val Met Thr Cys Leu
          70                  75                  80

 gca ttt gtc aag cct gcc atc aac aac atc tct ctg atg acc ctg gga     1063
 Ala Phe Val Lys Pro Ala Ile Asn Asn Ile Ser Leu Met Thr Leu Gly
      85                  90                  95

 gtt cct tgc gct gca ctg ctc atc aca gag cta aag agg tgt gac aac     1111
 Val Pro Cys Ala Ala Leu Leu Ile Thr Glu Leu Lys Arg Cys Asp Asn
 100                 105                 110                 115

 atg cgt gtg ttt aag ctg ggc ctc ttc tcg ggc ctc tgg tgg acc ctg     1159
 Met Arg Val Phe Lys Leu Gly Leu Phe Ser Gly Leu Trp Trp Thr Leu
                 120                 125                 130

 gcc ctg ttc tgc tgg atc agt gac cga gct ttc tgc gag ctg ctg tca     1207
 Ala Leu Phe Cys Trp Ile Ser Asp Arg Ala Phe Cys Glu Leu Leu Ser
             135                 140                 145

 tcc ttc aac ttc ccc tac ctg cac tgc atg tgg cac atc ctc atc tgc     1255
 Ser Phe Asn Phe Pro Tyr Leu His Cys Met Trp His Ile Leu Ile Cys
         150                 155                 160

 ctt gct gcc tac ctg ggc tgt gta tgc ttt gcc tac ttt gat gct gcc     1303
 Leu Ala Ala Tyr Leu Gly Cys Val Cys Phe Ala Tyr Phe Asp Ala Ala
     165                 170                 175

 tca gag att cct gag caa ggc cct gtc atc aag ttc tgg ccc aat gag     1351
 Ser Glu Ile Pro Glu Gln Gly Pro Val Ile Lys Phe Trp Pro Asn Glu
 180                 185                 190                 195

 aaa tgg gcc ttc att ggt gtc ccc tat gtg tcc ctc ctg tgt gcc aac     1399
 Lys Trp Ala Phe Ile Gly Val Pro Tyr Val Ser Leu Leu Cys Ala Asn
                 200                 205                 210

 aag aaa tca tca gtc aag atc acg tga tggca agatggtggc tggcttctct     1451
 Lys Lys Ser Ser Val Lys Ile Thr 
             215

 gcttatcgcc cctcatgcag tgggcttcct ttgctaggaa gacagccaag ggagttcgaa   1511

 tagttggggt gagggctatg tgttaaaaaa ctatatgtgc gtgggctctt aatttcttta   1571

 gagctcttta gaggtacgga tttgagctct gtcgtatgga acaaagattc cc           1623




      <210> 208
      <211> 474
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(412)

      <220>
      <221> misc_feature
      <222> (1)...(474)
      <223> n = a,t,c or g

      <400> 208
 aggagggggn nnnnnnnaat cgaacacctg agagactgtg cggaattcgc tagac atg      58
                                                              Met
                                                                1

 gtc act cct gct gga tgt cta ggt ggt aga aac caa gga cct agg gaa      106
 Val Thr Pro Ala Gly Cys Leu Gly Gly Arg Asn Gln Gly Pro Arg Glu
               5                  10                  15

 ata cca gct aca gcc ttt ccc cgc tca tcc aga gca gga caa aca ggc      154
 Ile Pro Ala Thr Ala Phe Pro Arg Ser Ser Arg Ala Gly Gln Thr Gly
          20                  25                  30

 cag gcg gtg tca gga gcc cag gtc tcc agc tgg agg gaa cgt caa ccc      202
 Gln Ala Val Ser Gly Ala Gln Val Ser Ser Trp Arg Glu Arg Gln Pro
      35                  40                  45

 tgc ggt ggg agt agg ggc cct ttg cac atc cta ggc aca gat ggt aat      250
 Cys Gly Gly Ser Arg Gly Pro Leu His Ile Leu Gly Thr Asp Gly Asn
  50                  55                  60                  65

 gta gac acc aca ggt aag ctg ggc ttg gta cct acc cct ccc cgg att      298
 Val Asp Thr Thr Gly Lys Leu Gly Leu Val Pro Thr Pro Pro Arg Ile
                  70                  75                  80

 cag aaa gaa acc aaa caa gga gct ttg tgc gga atg aaa cct cct ttc      346
 Gln Lys Glu Thr Lys Gln Gly Ala Leu Cys Gly Met Lys Pro Pro Phe
              85                  90                  95

 ctc cca gaa gca ctg ctg act gtt tgg tgg ttg cca ttt gtg gca gtg      394
 Leu Pro Glu Ala Leu Leu Thr Val Trp Trp Leu Pro Phe Val Ala Val
         100                 105                 110

 agc ctt tgt ttg ttc tga ggttgg gctggtttct cctcttggtc ctgccctaca      448
 Ser Leu Cys Leu Phe 
     115

 gatcataaag gagaacagca agaggt                                         474




      <210> 209
      <211> 2575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2364)

      <220>
      <221> misc_feature
      <222> (1)...(2575)
      <223> n = a,t,c or g

      <400> 209
  atg aag aat ttg gaa ttc cag act gag tat ctt ttg tgt gac tgt aac      48
  Met Lys Asn Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp Cys Asn
    1               5                  10                  15

 ata ctg tgg atg cat cgc tgg gta aag gag aag aac atc acg gta cgg       96
 Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr Val Arg
              20                  25                  30

 gat acc agg tgt gtt tat cct aag tca ctg cag gcc caa cca gtc aca      144
 Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro Val Thr
          35                  40                  45

 ggc gtg aag cag gag ctg ttg aca tgc gac cct ccg ctt gaa ttg ccg      192
 Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu Leu Pro
      50                  55                  60

 tct ttc tac atg act cca tct cat cgc caa gtt gtg ttt gaa gga gac      240
 Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu Gly Asp
  65                  70                  75                  80

 agc ctt cct ttc cag tgc atg gct tca tat att gat cag gac atg caa      288
 Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp Met Gln
                  85                  90                  95

 gtg ttg tgg tat cag gat ggg aga ata gtt gaa acc gat gaa tcg caa      336
 Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu Ser Gln
             100                 105                 110

 ggt att ttt gtt gaa aag aac atg att cac aac tgc tcc ttg att gca      384
 Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu Ile Ala
         115                 120                 125

 agt gcc cta acc att tct aat att cag gct gga tct act gga aat tgg      432
 Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly Asn Trp
     130                 135                 140

 ggc tgt cat gtc cag acc aaa cgt ggg aat aat acg agg act gtg gat      480
 Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr Val Asp
 145                 150                 155                 160

 att gtg gta tta gag agt tct gca cag tac tgt cct cca gag agg gtg      528
 Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu Arg Val
                 165                 170                 175

 gta aac aac aaa ggt gac ttc aga tgg ccc aga aca ttg gca ggc att      576
 Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala Gly Ile
             180                 185                 190

 act gca tat ctg cag tgt acg cgg aac acc cat ggc agt ggg ata tat      624
 Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly Ile Tyr
         195                 200                 205

 ccc gga aac cca cag gat gag aga aaa gct tgg cgc aga tgt gat aga      672
 Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys Asp Arg
     210                 215                 220

 ggt ggc ttt tgg gca gat gat gat tat tct cgc tgt cag tat gca aat      720
 Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr Ala Asn
 225                 230                 235                 240

 gat gtc act aga gtt ctt tat atg ttt aat cag atg ccc ctc aat ctt      768
 Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu Asn Leu
                 245                 250                 255

 acc aat gcc gtg gca aca gct cga cag tta ctg gct tac act gtg gaa      816
 Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr Val Glu
             260                 265                 270

 gca gcc aac ttt tct gac aaa atg gat gtt ata ttt gtg gca gaa atg      864
 Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala Glu Met
         275                 280                 285

 att gaa aaa ttt gga aga ttt acc aag gag gaa aaa tca aaa gag cta      912
 Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys Glu Leu
     290                 295                 300

 ggt gac gtg atg gtt gac att gca agt aac atc atg ttg gct gat gaa      960
 Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala Asp Glu
 305                 310                 315                 320

 cgt gtc ctg tgg ctg gcg cag agg gaa gct aaa gcc tgc agt agg att     1008
 Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser Arg Ile
                 325                 330                 335

 gtg cag tgt ctt cag cgc att gct acc tac cgg cta gcc ggt gga gct     1056
 Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly Gly Ala
             340                 345                 350

 cac gtt tat tca aca tat tca ccc aat att gct ctg gaa gct tat gtc     1104
 His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala Tyr Val
         355                 360                 365

 atc aag tct act ggc ttc acg ggg atg acc tgt acc gtg ttc cag aaa     1152
 Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe Gln Lys
     370                 375                 380

 gtg gca gcc tct gat cgt aca gga ctt tcg gat tat ggg agg cgg gat     1200
 Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg Arg Asp
 385                 390                 395                 400

 cca gag gga aac ctg gat aag cag ctg agc ttt aag tgc aat gtt tca     1248
 Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn Val Ser
                 405                 410                 415

 aat aca ttt tcg agt ctg gca cta aag aat act att gtg gag gct tct     1296
 Asn Thr Phe Ser Ser Leu Ala Leu Lys Asn Thr Ile Val Glu Ala Ser
             420                 425                 430

 att cag ctt cct cct tcc ctt ttc tca cca aag caa aaa aga gaa ctc     1344
 Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg Glu Leu
         435                 440                 445

 aga cca act gat gac tct ctt tac aag ctt caa ctc att gca ttc cgc     1392
 Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala Phe Arg
     450                 455                 460

 aat gga aag ctt ttt cca gcc act gga aat tca aca aat ttg gct gat     1440
 Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu Ala Asp
 465                 470                 475                 480

 gat gga aaa cga cgt act gtg gtt acc cct gtg att ctc acc aaa ata     1488
 Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu Thr Lys Ile
                 485                 490                 495

 gat ggt gtg aat gta gat acc cac cac atc cct gtt aat gtg aca ctg     1536
 Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn Val Thr Leu
             500                 505                 510

 cgt cga att gca cat gga gca gat gct gtt gca gcc cgg tgg gat ttc     1584
 Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp Asp Phe
         515                 520                 525

 gat ttg ctg aac gga caa gga ggc tgg aag tca gat ggg tgc cat ata     1632
 Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys His Ile
     530                 535                 540

 ctc tat tca gat gaa aat atc act acg att cag tgc tac tcc ctt agt     1680
 Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr Ser Leu Ser
 545                 550                 555                 560

 aac tat gca gtt tta atg gat ttg acg gga tct gaa cta tac acc cag     1728
 Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu Tyr Thr Gln
                 565                 570                 575

 gcg gcc agc ctc ctg cat cct gtg gtt tat act acc gct atc att ctc     1776
 Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala Ile Ile Leu
             580                 585                 590

 ctc tta tgt ctc tta gcc gtc att gtc agt tac ata tac cat cac agt     1824
 Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His His Ser
         595                 600                 605

 ttg att aga atc agc ctc aag agc tgg cac atg ctt gtg aac ttg tgc     1872
 Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn Leu Cys
     610                 615                 620

 ttt cat att ttc cta acc tgt gtg gtc ttt gtg gga gga ata acc cag     1920
 Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly Ile Thr Gln
 625                 630                 635                 640

 act agg aat gcc agc atc tgc caa gca gtt ggg ata att ctt cac tat     1968
 Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu His Tyr
                 645                 650                 655

 tcc acc ctt gcc aca gta cta tgg gta gga gtg aca gct cga aat atc     2016
 Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala Arg Asn Ile
             660                 665                 670

 tac aaa caa gtc act aaa aaa gct aaa aga tgc cag gat cct gat gaa     2064
 Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp Pro Asp Glu
         675                 680                 685

 cca cca cct cca cca aga cca atg ctc aga ttt tac ctg att ggt ggt     2112
 Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile Gly Gly
     690                 695                 700

 ggt atc ccc atc att gtt tgc ggc ata act gca gca gcg aac att aag     2160
 Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala Asn Ile Lys
 705                 710                 715                 720

 aat tac ggc agt cgg cca aac gca ccc tat tgc tgg atg gca tgg gaa     2208
 Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala Trp Glu
                 725                 730                 735

 ccc tcc ttg gga ggc ttc tat ggg cca gcc agc ttc atc act ttt gta     2256
 Pro Ser Leu Gly Gly Phe Tyr Gly Pro Ala Ser Phe Ile Thr Phe Val
             740                 745                 750

 aac tgc atg tac ttt ctg agc ata ttt att cag ttg aaa aga cac cct     2304
 Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg His Pro
         755                 760                 765

 gag cgc aaa tat gag ctt aag gag ccc acg gag aga gca aca gag att     2352
 Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Arg Ala Thr Glu Ile
     770                 775                 780

 ggc agc caa tga aaa tggcgaaata aatcatcagg attcaatgnc tttgtctctg     2407
 Gly Ser Gln 
 785

 atttctacat cagccttgga aaatgagcac acttttcatt ctcagctctt gggggccagc   2467

 cttactttgc tcttatatgg tgcactgggg atgtttgggc ttttggctgg ttctttggat   2527

 taccccttgg acttggttta acttcnnttt tggggcccca gttanctt                2575




      <210> 210
      <211> 1349
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1041)

      <400> 210
  atg tac aac ggg tcg tgc tgc cgc atc gag ggg gac acc atc tcc cag      48
  Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln
    1               5                  10                  15

 gtg atg ccg ccg ctg ctc att gtg gcc ttt gtg ctg ggc gca cta ggc       96
 Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly
              20                  25                  30

 aat ggg gtc gcc ctg tgt ggt ttc tgc ttc cac atg aag acc tgg aag      144
 Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys
          35                  40                  45

 ccc agc act gtt tac ctt ttc aat ttg gcc gtg gct gat ttc ctc ctt      192
 Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu
      50                  55                  60

 atg atc tgc ctg cct ttt cgg aca gac tat tac ctc aga cgt aga cac      240
 Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His
  65                  70                  75                  80

 tgg gct ttt ggg gac att ccc tgc cga gtg ggg ctc ttc acg ttg gcc      288
 Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala
                  85                  90                  95

 atg aac agg gcc ggg agc atc gtg ttc ctt acg gtg gtg gct gcg gac      336
 Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp
             100                 105                 110

 agg tat ttc aaa gtg gtc cac ccc cac cac gcg gtg aac act atc tcc      384
 Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser
         115                 120                 125

 acc cgg gtg gcg gct ggc atc gtc tgc acc ctg tgg gcc ctg gtc atc      432
 Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile
     130                 135                 140

 ctg gga aca gtg tat ctt ttg ctg gag aac cat ctc tgc gtg caa gag      480
 Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu
 145                 150                 155                 160

 acg gcc gtc tcc tgt gag agc ttc atc atg gag tcg gcc aat ggc tgg      528
 Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp
                 165                 170                 175

 cat gac atc atg ttc cag ctg gag ttc ttt atg ccc ctc ggc atc atc      576
 His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile
             180                 185                 190

 tta ttt tgc tcc ttc aag att gtt tgg agc ctg agg cgg agg cag cag      624
 Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln
         195                 200                 205

 ctg gcc aga cag gct cgg atg aag aag gcg acc cgg ttc atc atg gtg      672
 Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val
     210                 215                 220

 gtg gca att gtg ttc atc aca tgc tac ctg ccc agc gtg tct gct aga      720
 Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg
 225                 230                 235                 240

 ctc tat ttc ctc tgg acg gtg ccc tcg agt gcc tgc gat ccc tct gtc      768
 Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val
                 245                 250                 255

 cat ggg gcc ctg cac ata acc ctc agc ttc acc tac atg aac agc atg      816
 His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met
             260                 265                 270

 ctg gat ccc ctg gtg tat tat ttt tca agc ccc tcc ttt ccc aaa ttc      864
 Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe
         275                 280                 285

 tac aac aag ctc aaa atc tgc agt ctg aaa ccc aag cag cca gga cac      912
 Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His
     290                 295                 300

 tca aaa aca caa agg ccg gaa gag atg cca att tcg aac ctc ggt cgc      960
 Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg
 305                 310                 315                 320

 agg agt tgc atc agt gtg gca aat agt ttc caa agc cag tct gat ggg     1008
 Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly
                 325                 330                 335

 caa tgg gat ccc cac att gtt gag tgg cac tga acaagcag accaacaaca     1059
 Gln Trp Asp Pro His Ile Val Glu Trp His 
             340                 345

 ctgaggaaga tagagtggtg acttagaatt aactcgtgct aaggggtcgg gggctttgaa   1119

 aatgccaccc ccctttctta ttgcaagacg gcttctcgca catgaactgc atccttctca   1179

 ttctgtcgga aatgaaattc acacaactat accttttggg gaggttccag ttgattgaag   1239

 tgagttggct gcattttctt atctgatcac aatggcaggg gacagaatgt gcatggagtg   1299

 gagcatgtgt gtgttgggag gggggctagg aactgcacag cccttgtgta              1349




      <210> 211
      <211> 5483
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2180)..(4777)

      <400> 211
 caggacacga ggaaactgtt aatgacttgg gctttggaag tagctgttgt aatgaagaag     60

 tccgaaacat atgcaccttt attctgtctt ccgtctttcc ataaattttg caaaggcctt    120

 ttagccgaca ctctcgttga agatgtgaat atctgtctgc aggcatgcag cagtctacat    180

 gctctatcct cttccttgcc agatgatctt ttacagagat gtgttgatgt ttgccgtgtc    240

 caactagtgc accgtggaac ttgtattcga caagcatttg gaaaactgtt gaaatcaatt    300

 cctttaggtg ttttcctaag cgataacaat cacacagaaa ttcaagaaat ttctttagca    360

 ttaagaagtc acatgagtaa agcaccaagt aatacattcc acccccaaga tttctctgat    420

 gttattagtt ttattttgta tgggaactct catagaacag ggaaggacaa ttggttggaa    480

 agactgttct atagctgcca gagactggat aagcgtgacc agtcaacaat tccacgcaat    540

 ctcctgaaga cagatgctat cctttggcag tgggccatat gggaagctgc acaattcact    600

 gttctttcta agctgagaac cccactgggc agagctcaag acaccttcca gacaattgaa    660

 ggtatcattc gaagtctcgc aggtcacaca ttaaaccctg atcaggatgt tagtcagtgg    720

 acaactgcag acagtgatga aggccatggt aacaaccaac ttagacttgt tcttcttctg    780

 cagtatctgg aaaatctgga gaaattaatg tataatgcat acgagggatg tgctaatgcc    840

 ttaacttcac ctcccaaggt cattagaact tttttgtata ccaatcgcca aacttgtcag    900

 gactggctaa cgcggattcg actctccatc atgagggtag gattgttggc aggccagcct    960

 gcagtgacag tgagacatgg ctttgacttg cttacagaga tgaaaacaac cagcctatct   1020

 caggggaatg aattggaagt aagcattatg atggtggtag aagcactatg tgaacttcat   1080

 tgtcctgaag ctatacaggg aattgctgtc tggtcatcat ctattgttgg aaaacatctt   1140

 ctgtggatta actcagtggc tcaacaggct gaagggaggt ttgaaaaggc ctctgtggag   1200

 taccaggaac acctgtgtgc catgacaggt gttgattgct gcatctccag ctttgacaaa   1260

 tcggtgctca ccttagccag tgctgggtgt aagagtgcca gcctgaaaca ttgtctgaat   1320

 ggtgaatcca gaaaaagtgt gctgtccaaa ccgactgact cttcccctga ggttataaat   1380

 tatttaggaa acaaagcatg tgagtgctac atctcaactg ccgattgggc tgctgtgcag   1440

 gaatggcaga acgctatcca tgacttgaaa aagagtacca gtagcacttc cctcaacctg   1500

 aaagctgact tcaactatat aaaatcatta agcagctttg agtctggaaa atttgtcgaa   1560

 tgtaccgagc aattagaatt gttaccagga gaaaatatca atctacttgc tggaggatca   1620

 aaagaaaaaa tagacatgaa aaaactgctt cgtaacatgt gaagtccaga tccaagggaa   1680

 cctcagaaat ccattgaagt tccattgtta agaagttctg tttgtttggc aactgcttta   1740

 aacccgatag aacaagatca gaagtggcag tctataactg aaaatgtggt aaagtacttg   1800

 aagcaaacat cccgcatcgc tattggacct ctgagacttt ctactttaac agtttcacag   1860

 tctttgccag ttctaagtac cttgcagctg tattgctcgt ctgctttgga gaccacagtt   1920

 tctaacagac tttcaacaga ggactgtctt attccactct tcggcgaagc tttacgttca   1980

 tgtaaacagc atgacgtgag gccgtggatg caggcattaa ggtatactgt gtaccagaat   2040

 cagttgttgg agaaaattaa aggtatgatc tcgtgaaatc ttgagagaaa ctgaatgacg   2100

 aatgaaacta ttgttcctgt ttcacacaga agaaaactga ggttggcact catcatgagc   2160

 ccctgttctc attctgcaa atg gtg aag ctc tct att gtc ctg acc cca cag    2212
                      Met Val Lys Leu Ser Ile Val Leu Thr Pro Gln
                        1               5                  10

 ttc ctg tcc cat gac cag ggc cag ctc acc aag gag ctg cag cag cat     2260
 Phe Leu Ser His Asp Gln Gly Gln Leu Thr Lys Glu Leu Gln Gln His
              15                  20                  25

 gta aag tca gtg aca tgc cca tgc gag tac ctg agg aag gtt atc aat     2308
 Val Lys Ser Val Thr Cys Pro Cys Glu Tyr Leu Arg Lys Val Ile Asn
          30                  35                  40

 act ctg gct gac cat cat cat cgt ggg act gac ttt ggt gga agt cct     2356
 Thr Leu Ala Asp His His His Arg Gly Thr Asp Phe Gly Gly Ser Pro
      45                  50                  55

 tgg tta cat gtc att att gca ttt ccg aca agt tat aaa gtt gtc att     2404
 Trp Leu His Val Ile Ile Ala Phe Pro Thr Ser Tyr Lys Val Val Ile
  60                  65                  70                  75

 acc ctc tgg ata gtt tac ctt tgg gtg tct ctc ctg aag act atc ttc     2452
 Thr Leu Trp Ile Val Tyr Leu Trp Val Ser Leu Leu Lys Thr Ile Phe
                  80                  85                  90

 tgg tct cga aat gga cat gat gga tcc acg gat gta cag cag aga gcc     2500
 Trp Ser Arg Asn Gly His Asp Gly Ser Thr Asp Val Gln Gln Arg Ala
              95                 100                 105

 tgg agg tcc aac cgc cgt aga cag gaa ggg ctg agg tcc att tgt atg     2548
 Trp Arg Ser Asn Arg Arg Arg Gln Glu Gly Leu Arg Ser Ile Cys Met
         110                 115                 120

 cac aca aag aaa aga gtt tct tcc ttt cga gga aat aaa att ggc ctg     2596
 His Thr Lys Lys Arg Val Ser Ser Phe Arg Gly Asn Lys Ile Gly Leu
     125                 130                 135

 aaa gac gtc att act cta cgg aga cat gtg gaa aca aaa gtt aga gct     2644
 Lys Asp Val Ile Thr Leu Arg Arg His Val Glu Thr Lys Val Arg Ala
 140                 145                 150                 155

 aaa atc cgt aag agg aag gtg aca acg aaa atc aac cat cat gac aaa     2692
 Lys Ile Arg Lys Arg Lys Val Thr Thr Lys Ile Asn His His Asp Lys
                 160                 165                 170

 atc aat gga aag agg aag acc gcc aga aaa cag aaa atg ttt caa cgt     2740
 Ile Asn Gly Lys Arg Lys Thr Ala Arg Lys Gln Lys Met Phe Gln Arg
             175                 180                 185

 gcg caa gag ttg cgg cgg cga gca gag gac tac cac aaa tgc aaa atc     2788
 Ala Gln Glu Leu Arg Arg Arg Ala Glu Asp Tyr His Lys Cys Lys Ile
         190                 195                 200

 ccc cct tct gca aga aag gct ctt tgc aac tgg gtc aga atg gcg gca     2836
 Pro Pro Ser Ala Arg Lys Ala Leu Cys Asn Trp Val Arg Met Ala Ala
     205                 210                 215

 gcg gag cat cgt cat tct tca gga ttg ccc tac tgg ccc tac ctc aca     2884
 Ala Glu His Arg His Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr
 220                 225                 230                 235

 gct gaa act tta aaa aac agg atg ggc cac cag cca cct cct cca act     2932
 Ala Glu Thr Leu Lys Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr
                 240                 245                 250

 caa caa cat tct ata act gat aac tcc ctg agc ctc aag aca cct ccc     2980
 Gln Gln His Ser Ile Thr Asp Asn Ser Leu Ser Leu Lys Thr Pro Pro
             255                 260                 265

 gag tgt ctg ctc act ccc ctt cca ccc tca gcg gat gat aat ctc aag     3028
 Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys
         270                 275                 280

 aca cct ccc gag tgt gtg ctc act ccc ctt cca ccc tca gcg gat gat     3076
 Thr Pro Pro Glu Cys Val Leu Thr Pro Leu Pro Pro Ser Ala Asp Asp
     285                 290                 295

 aat ctc aag aca cct ccc gag tgt gtg ctc act ccc ctt cca ccc tca     3124
 Asn Leu Lys Thr Pro Pro Glu Cys Val Leu Thr Pro Leu Pro Pro Ser
 300                 305                 310                 315

 gcg gat gat aat ctc aag aca cct cct gag tgt ctg ctc act ccc ctt     3172
 Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu
                 320                 325                 330

 cca ccc tca gcg gat gat aat ctc aag aca cct ccc gag tgt cta ctc     3220
 Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu
             335                 340                 345

 act ccc ctt cca ccc tca gct cta ccc tca gct cca ccc tca gcg gat     3268
 Thr Pro Leu Pro Pro Ser Ala Leu Pro Ser Ala Pro Pro Ser Ala Asp
         350                 355                 360

 gat aat ctc aag aca cgt gcc gag tgt ctg ctc cat ccc ctt cca ccc     3316
 Asp Asn Leu Lys Thr Arg Ala Glu Cys Leu Leu His Pro Leu Pro Pro
     365                 370                 375

 tca gcg gat gat aat ctc aag aca cct tcc gag cgt cag ctc act ccc     3364
 Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro
 380                 385                 390                 395

 ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag aca cct     3412
 Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro
                 400                 405                 410

 gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat ctc     3460
 Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu
             415                 420                 425

 aag aca cct tcc gag cgt cag ctc act ccc ctt cca ccc tca gct cca     3508
 Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro
         430                 435                 440

 ccc tca gca gat gat aat atc aag aca cct gcc gag cgt ctg cgg ggg     3556
 Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly
     445                 450                 455

 ccg ctt cca ccc tca gcg gat gat aat ctc aag aca cct tcc gag cgt     3604
 Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg
 460                 465                 470                 475

 cag ctc act ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat     3652
 Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn
                 480                 485                 490

 atc aag aca cct gcc gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg     3700
 Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala
             495                 500                 505

 gat gat aat ctc aag aca cct tcc gag cgt cag ctc act ccc ctt cca     3748
 Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro
         510                 515                 520

 ccc tca gct cca ccc tca gca gat gat aat atc aag aca cct gcc gag     3796
 Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu
     525                 530                 535

 cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat aat ctc aag aca     3844
 Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr
 540                 545                 550                 555

 cct tcc gag cgt cag ctc act ccc ctt cca ccc tca gct cca ccc tca     3892
 Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser
                 560                 565                 570

 gca gat gat aac atc aag aca cct gcc ttc cac cct cag cgg atg ata     3940
 Ala Asp Asp Asn Ile Lys Thr Pro Ala Phe His Pro Gln Arg Met Ile
             575                 580                 585

 atc tca aga cac ctt ccg agc gtc agc tca ctc ccc ttc cac cct cag     3988
 Ile Ser Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln
         590                 595                 600

 ctc cac cct cag cag atg ata ata tca aga tac ctg ctg agc gtc tgc     4036
 Leu His Pro Gln Gln Met Ile Ile Ser Arg Tyr Leu Leu Ser Val Cys
     605                 610                 615

 gga ttc cgc ttc cac cat cag ccg atg ata atc tca aga cac ctt ccg     4084
 Gly Phe Arg Phe His His Gln Pro Met Ile Ile Ser Arg His Leu Pro
 620                 625                 630                 635

 agc gtc agc tca ctc ccc ttc cac cct cag ctc cac cct cag cag atg     4132
 Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro Gln Gln Met
                 640                 645                 650

 ata ata tca aga cac ctg ccg agc gtc tgc ggg ggc cgc ttc cac cct     4180
 Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly Arg Phe His Pro
             655                 660                 665

 cag cgg atg ata atc tca aga cac ctt ccg agc atc agc tca ctc ccc     4228
 Gln Arg Met Ile Ile Ser Arg His Leu Pro Ser Ile Ser Ser Leu Pro
         670                 675                 680

 ttc cac cct cag ctc cac cct cag cag atg ata ata tca aga cac ctg     4276
 Phe His Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg His Leu
     685                 690                 695

 ccg agc gtc tgc ggg ggc cgc ttc cac cct cag cgg atg ata atc tca     4324
 Pro Ser Val Cys Gly Gly Arg Phe His Pro Gln Arg Met Ile Ile Ser
 700                 705                 710                 715

 aga cac ctt ccg agc gtc agc tca ctc ccc ttc cac cct cag ctc cac     4372
 Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu His
                 720                 725                 730

 cct cag cag atg ata ata tca aga cac ctg ccg agc gtc tgc ggg ggc     4420
 Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly
             735                 740                 745

 cgc ttc cac cct cag cgg atg ata atc tca aga cac ctt ccg agc gtc     4468
 Arg Phe His Pro Gln Arg Met Ile Ile Ser Arg His Leu Pro Ser Val
         750                 755                 760

 agc tca ctc ccc ttc cac act cag ctc cac cct cag cag atg ata ata     4516
 Ser Ser Leu Pro Phe His Thr Gln Leu His Pro Gln Gln Met Ile Ile
     765                 770                 775

 tca aga cac ctg ccg agc gtc tgc ggg gag cgt ctg cgg ggg ccg ctt     4564
 Ser Arg His Leu Pro Ser Val Cys Gly Glu Arg Leu Arg Gly Pro Leu
 780                 785                 790                 795

 cca ccc tca gcg gat gat aat ctc aag aca cct tcc gag cgt cag ctc     4612
 Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu
                 800                 805                 810

 act ccc ctt cca ccc tca gct cca ccc tca gca gat gat aat atc aag     4660
 Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys
             815                 820                 825

 aca cct gct gag cgt ctg cgg ggg ccg ctt cca ccc tca gcg gat gat     4708
 Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp
         830                 835                 840

 aat ctc aag aca cct tac cga gcg tca gct cac tcc cct tcc acc ctc     4756
 Asn Leu Lys Thr Pro Tyr Arg Ala Ser Ala His Ser Pro Ser Thr Leu
     845                 850                 855

 agc tcc act ctc agc aga tga ta ctatcaagat acctgctgag cgtctgcgga     4809
 Ser Ser Thr Leu Ser Arg 
 860                 865

 ttccgcttcc accatcagcc gatgataatc tcaagacacc ttccgagcgt cagatcactc   4869

 cccttccacc ctcagctcca ccctcagcag atgataatat caagacacct gccgagcgtc   4929

 tgcgggggcc gcttccaccc tcagcggatg ataatctcaa gacaccttcc gagcgtctgc   4989

 tcactcccct tccaccctca gcggatgata atctcaagac accttccgag tgttgtgctc   5049

 acttcccttc caccctcagc ggattataat ctcaagacac ctcctgagtg tctgctcact   5109

 ccccttccac tctctgcgga ttataatctc aatacacctc ccgagtgtct actcaatccc   5169

 cttccacctc ctagctctac cttcagcttc caccctcagc ggatgataat ctcaagacac   5229

 gtcccgagtg tttgctccat ccccattcca ccctcagcgg atgataatct caagacacct   5289

 tccgagcgtc agctcactcc ccttccaccc tcagctccac cctcagcaga tgataatatc   5349

 aagacacctg ccttccaccc tcagcggatg atctcaagac accttccgag cgtcagctca   5409

 ctccccttcc accctcagct ccaccctcag cagatgataa tatcaagata cctgctgagc   5469

 gtctgcggat tccg                                                     5483




      <210> 212
      <211> 744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(743)

      <400> 212
 tgtcgttgtt ctgagaggct gccaggattt catgagccca cacaaaaaca gaagaccata     60

 gcctgagcta aaagcaaagc cccccatgtg tgtataaatc cttaagtgga gaagtgctca    120

 gtgcctgaaa tgtgaaacac caaaaaatca ctgacctcca gccaagtgca agcctcaagt    180

 ccacacgcaa ccgctgtgtg gagctcggtg ccgctgagac tttgaaaaat cctcagcaaa    240

 actggccaac ggcctgaccc    atg aat tgg cct cca aca cac tgg gct gtc     290
                          Met Asn Trp Pro Pro Thr His Trp Ala Val
                            1               5                  10

 gcc aag agg ggg tgt agt ggg tgc aat tgc cct tca ggc ctc agc tcc      338
 Ala Lys Arg Gly Cys Ser Gly Cys Asn Cys Pro Ser Gly Leu Ser Ser
                  15                  20                  25

 cag gga agg gag gaa aat tcc cca gac ccc cag ggg tcg ggg ata cag      386
 Gln Gly Arg Glu Glu Asn Ser Pro Asp Pro Gln Gly Ser Gly Ile Gln
              30                  35                  40

 aca gct gga ggc cct gca cca tcg gtg ttt ctg ctc ccc ctt ccc cag      434
 Thr Ala Gly Gly Pro Ala Pro Ser Val Phe Leu Leu Pro Leu Pro Gln
          45                  50                  55

 gtg aac ctt ctc atc ccc gtg gcg tac ttg gtc ttc tgg gcc ttc ctg      482
 Val Asn Leu Leu Ile Pro Val Ala Tyr Leu Val Phe Trp Ala Phe Leu
      60                  65                  70

 ctg gtc ttc agc ttc atc tca gag cct atg gtc tgt ggg gtc ggc gtc      530
 Leu Val Phe Ser Phe Ile Ser Glu Pro Met Val Cys Gly Val Gly Val
  75                  80                  85                  90

 atc atc atc ctt acg ggg gtg ccc att ttc ttt ctg gga gtg ttc tgg      578
 Ile Ile Ile Leu Thr Gly Val Pro Ile Phe Phe Leu Gly Val Phe Trp
                  95                 100                 105

 aga agc aaa cca aag tgt gtg cac aga ctc aca ggg tcc atg aca cac      626
 Arg Ser Lys Pro Lys Cys Val His Arg Leu Thr Gly Ser Met Thr His
             110                 115                 120

 tgg ggc cag gag ctg tgt ttc gtg gtc tac ccc cag gac gcc ccc gaa      674
 Trp Gly Gln Glu Leu Cys Phe Val Val Tyr Pro Gln Asp Ala Pro Glu
         125                 130                 135

 gag gag gag aat ggc ccc tgc cca ccc tcc ctg ctg cct gcc aca gac      722
 Glu Glu Glu Asn Gly Pro Cys Pro Pro Ser Leu Leu Pro Ala Thr Asp
     140                 145                 150

 aag ccc tcg aag cca caa tga g                                        744
 Lys Pro Ser Lys Pro Gln 
 155                 160





      <210> 213
      <211> 1401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(1361)

      <400> 213
 ctggaacaaa c atg gcc gct ctg gcg ccc gtc ggc tcc ccc gcc tcc cgc      50
              Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg
                1               5                  10

 ggt cct agg ctg gcc gcg ggc ctc cgg ctg ctc cca atg ctg ggt ttg       98
 Gly Pro Arg Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu
      15                  20                  25

 ctg cag ttg ctg gcc gag cct ggc ctg ggc cgc gtc cat cac ctg gca      146
 Leu Gln Leu Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala
  30                  35                  40                  45

 ctc aag gat gat gtg agg cat aaa gtt cat ctg aac acc ttt ggc ttc      194
 Leu Lys Asp Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe
                  50                  55                  60

 ttc aag gat ggg tac atg gtg gtg aat gtc agt agc ctc tca ctg aat      242
 Phe Lys Asp Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn
              65                  70                  75

 gag cct gaa gac aag gat gtg act att gga ttt agc cta gac cgt aca      290
 Glu Pro Glu Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr
          80                  85                  90

 aag aat gat ggc ttt ttt ttt tac ctg gat gaa gat gtg aat tac tgt      338
 Lys Asn Asp Gly Phe Phe Phe Tyr Leu Asp Glu Asp Val Asn Tyr Cys
      95                 100                 105

 att tta aag aaa cag tct gtc tct gtc acc ctt tta atc cta gac atc      386
 Ile Leu Lys Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile
 110                 115                 120                 125

 tcc aga agt gag gta aga gta aag tct cca cca gaa gct ggt acc cag      434
 Ser Arg Ser Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln
                 130                 135                 140

 tta cca aag atc atc ttc agc agg gat gag aaa gtc ctt ggt cag agc      482
 Leu Pro Lys Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser
             145                 150                 155

 cag gag cct aat gtt aac cct gct tca gca ggc aac cag acc cag aag      530
 Gln Glu Pro Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys
         160                 165                 170

 aca caa gat ggt gga aag tct aaa aga agt aca gtg gat tca aag gcc      578
 Thr Gln Asp Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala
     175                 180                 185

 atg gga gag aaa tcc ttt tct gtt cat aat aat ggt ggg gca gtg tca      626
 Met Gly Glu Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser
 190                 195                 200                 205

 ttt cag ttt ttc ttt aac atc agc act gat gac caa gaa ggc ctt tac      674
 Phe Gln Phe Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr
                 210                 215                 220

 agt ctt tat ttt cat aaa tgc ctt gga aaa gaa ttg cca agt gac aag      722
 Ser Leu Tyr Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys
             225                 230                 235

 ttt aca ttc agc ctt gat att gag atc aca gag aag aat cct gac agc      770
 Phe Thr Phe Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser
         240                 245                 250

 tac ctc tca gca gga gaa att cct ctc ccc aaa tta tac atc tca atg      818
 Tyr Leu Ser Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met
     255                 260                 265

 gcc ttt ttc ttc ttt ctt tct ggg acc atc tgg att cat atc ctt cga      866
 Ala Phe Phe Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg
 270                 275                 280                 285

 aaa cga cgg aat gat gta ttt aaa atc cac tgg ctg atg gcg gcc ctt      914
 Lys Arg Arg Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu
                 290                 295                 300

 cct ttc acc aag tct ctt tcc ttg gtg ttc cat gca att gac tac cac      962
 Pro Phe Thr Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His
             305                 310                 315

 tac atc tcc tcc cag ggc ttc cct atc gaa ggc tgg gct gtt gtg tac     1010
 Tyr Ile Ser Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr
         320                 325                 330

 tac ata act cac ctt ttg aaa ggg gcg cta ctc ttc atc acc att gca     1058
 Tyr Ile Thr His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala
     335                 340                 345

 ctc att ggc act ggc tgg gct ttc att aag cac atc ctt tct gat aaa     1106
 Leu Ile Gly Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys
 350                 355                 360                 365

 gac aaa aag atc ttc atg att gtc att cca ctc cag gtc ctg gca aat     1154
 Asp Lys Lys Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn
                 370                 375                 380

 gta gcc tac atc atc ata gag tcc acc gag gag ggc acg act gaa tat     1202
 Val Ala Tyr Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr
             385                 390                 395

 ggc ttg tgg aag gac tct cta ttt ctg gtc gac ctg ttg tgt tgt ggt     1250
 Gly Leu Trp Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly
         400                 405                 410

 gcc atc ctc ttc cca gtg gtg tgg tca atc aga cat tta caa gaa gca     1298
 Ala Ile Leu Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala
     415                 420                 425

 tca gca aca gat gga aaa ggc aag ttc tct cgt gct cat ttt gtg ttg     1346
 Ser Ala Thr Asp Gly Lys Gly Lys Phe Ser Arg Ala His Phe Val Leu
 430                 435                 440                 445

 ctc agc ttg ctc tga acccacgtgc tgcggcactg cggaggagtg gaggcagcct     1401
 Leu Ser Leu Leu 






      <210> 214
      <211> 839
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(785)

      <400> 214
 tggcatttct gactgtggga gcctcagttt cccagtcatc tgatgagcct gagcagcagc     60

 aaagtaccac tgtaagccat gag    atg tct cgt ctg aac tgg aaa ccc ttt     110
                              Met Ser Arg Leu Asn Trp Lys Pro Phe
                                1               5

 gta tat gac ggc ctt gcc tct atc act gct gag ttt gga act ttc ccc      158
 Val Tyr Asp Gly Leu Ala Ser Ile Thr Ala Glu Phe Gly Thr Phe Pro
  10                  15                  20                  25

 atg gac ctt gcc aaa aca cga ctt aga caa gca tca tat ggc acc att      206
 Met Asp Leu Ala Lys Thr Arg Leu Arg Gln Ala Ser Tyr Gly Thr Ile
                  30                  35                  40

 aaa att ggg att tac caa agc ttg aag caa tta tct gta gaa cgt tta      254
 Lys Ile Gly Ile Tyr Gln Ser Leu Lys Gln Leu Ser Val Glu Arg Leu
              45                  50                  55

 gaa gat gaa act ctt tta atc aac atg atc tgt ggg gta gtg tca ggg      302
 Glu Asp Glu Thr Leu Leu Ile Asn Met Ile Cys Gly Val Val Ser Gly
          60                  65                  70

 gtg ata ttt tcc act ata gcc aat ccc acc gat gtt cta aag att cga      350
 Val Ile Phe Ser Thr Ile Ala Asn Pro Thr Asp Val Leu Lys Ile Arg
      75                  80                  85

 atg cag gct caa gga agt ttg ttc caa ggg agc atg att ggc agc ttc      398
 Met Gln Ala Gln Gly Ser Leu Phe Gln Gly Ser Met Ile Gly Ser Phe
  90                  95                 100                 105

 atc gat ata tac caa cag gaa ggc acc agg ggt ctg tgg agg agt gtg      446
 Ile Asp Ile Tyr Gln Gln Glu Gly Thr Arg Gly Leu Trp Arg Ser Val
                 110                 115                 120

 gtt cca act gct cag cat gct gcc atc gtt gtg gga gta gag cta cca      494
 Val Pro Thr Ala Gln His Ala Ala Ile Val Val Gly Val Glu Leu Pro
             125                 130                 135

 gtc tat gat ttt act aag aag cac tta ata ttg tca gga atg atg gaa      542
 Val Tyr Asp Phe Thr Lys Lys His Leu Ile Leu Ser Gly Met Met Glu
         140                 145                 150

 gac aca act tta act cac ttt gtt tcc agc ttt aca tat ggt ttg gct      590
 Asp Thr Thr Leu Thr His Phe Val Ser Ser Phe Thr Tyr Gly Leu Ala
     155                 160                 165

 ggg gct ctt gcc tct aat cca ggt gat gtg gca ggc act cac gtg atg      638
 Gly Ala Leu Ala Ser Asn Pro Gly Asp Val Ala Gly Thr His Val Met
 170                 175                 180                 185

 aac cag agg gca atc gtg gga cat gtg gat ctc tat aag ggc act ttg      686
 Asn Gln Arg Ala Ile Val Gly His Val Asp Leu Tyr Lys Gly Thr Leu
                 190                 195                 200

 gat ggt att tta aaa atg tgg aaa cat gag ggc ttt ttt gta ttc aaa      734
 Asp Gly Ile Leu Lys Met Trp Lys His Glu Gly Phe Phe Val Phe Lys
             205                 210                 215

 gga ttt tgg cca aac tgg ctt tgg cgt gga ccc tgg aac atc att ctt      782
 Gly Phe Trp Pro Asn Trp Leu Trp Arg Gly Pro Trp Asn Ile Ile Leu
         220                 225                 230

 taa atta catatgagta gctcaagagg ctttaaatct aaggactgaa ttatatgtga      839
 






      <210> 215
      <211> 965
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(965)

      <400> 215
 gtagctctac tagaaat   atg gag agc gga aac caa tca aca gtg act gaa      50
                      Met Glu Ser Gly Asn Gln Ser Thr Val Thr Glu
                        1               5                  10

 ttt atc ttc act gga ttc cct cag ctt cag gat ggt agt ctc ctg tac       98
 Phe Ile Phe Thr Gly Phe Pro Gln Leu Gln Asp Gly Ser Leu Leu Tyr
              15                  20                  25

 ttc ttt cct tta ctt ttc atc tat act ttt att atc att gat aac tta      146
 Phe Phe Pro Leu Leu Phe Ile Tyr Thr Phe Ile Ile Ile Asp Asn Leu
          30                  35                  40

 tta atc ttc tct gct gta agg ctg gac acc cat ctc cac aac ccc atg      194
 Leu Ile Phe Ser Ala Val Arg Leu Asp Thr His Leu His Asn Pro Met
      45                  50                  55

 tat aat ttt atc agc att ttc tca ttt ctg gag atc tgg tac aca act      242
 Tyr Asn Phe Ile Ser Ile Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr
  60                  65                  70                  75

 gcc aca att ccc aag atg ctc tcc aac ctc atc agt gaa aag aag gcc      290
 Ala Thr Ile Pro Lys Met Leu Ser Asn Leu Ile Ser Glu Lys Lys Ala
                  80                  85                  90

 atc tca atg act ggc tgc atc ttg cag atg tat ttc ttc cac tca ctt      338
 Ile Ser Met Thr Gly Cys Ile Leu Gln Met Tyr Phe Phe His Ser Leu
              95                 100                 105

 gaa aac tca gag ggg atc ttg ctg acc acc atg gcc att gac aga tac      386
 Glu Asn Ser Glu Gly Ile Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr
         110                 115                 120

 gtt gcc atc tgc aac cct ctt cgc tat caa atg atc atg acc ccc cgg      434
 Val Ala Ile Cys Asn Pro Leu Arg Tyr Gln Met Ile Met Thr Pro Arg
     125                 130                 135

 ctc tgt gct caa ctc tct gca ggt tcc tgc ctc ttc ggt ttc ctt atc      482
 Leu Cys Ala Gln Leu Ser Ala Gly Ser Cys Leu Phe Gly Phe Leu Ile
 140                 145                 150                 155

 ctg ctt ccc gag att gtg atg att tcc aca ctg cct ttc tgt ggg ccc      530
 Leu Leu Pro Glu Ile Val Met Ile Ser Thr Leu Pro Phe Cys Gly Pro
                 160                 165                 170

 aac caa atc cat cag atc ttc tgt gac ttg gtc cct gtg cta agc ctg      578
 Asn Gln Ile His Gln Ile Phe Cys Asp Leu Val Pro Val Leu Ser Leu
             175                 180                 185

 gcc tgt aca gac acg tcc atg att ctg att gag gat gtg att cat gct      626
 Ala Cys Thr Asp Thr Ser Met Ile Leu Ile Glu Asp Val Ile His Ala
         190                 195                 200

 gtg acc atc atc att acc ttc cta atc att gcc ctg tcc tat gta aga      674
 Val Thr Ile Ile Ile Thr Phe Leu Ile Ile Ala Leu Ser Tyr Val Arg
     205                 210                 215

 att gtc act gtg ata ttg agg att ccc tct tct gaa ggg agg caa aag      722
 Ile Val Thr Val Ile Leu Arg Ile Pro Ser Ser Glu Gly Arg Gln Lys
 220                 225                 230                 235

 gct ttt tct acc tgt gca ggc cac ctc atg gtc ttc ctg ata ttc ttt      770
 Ala Phe Ser Thr Cys Ala Gly His Leu Met Val Phe Leu Ile Phe Phe
                 240                 245                 250

 ggc agt gta tca ctc atg tac ttg cgt ttc agc gac act tat cca cca      818
 Gly Ser Val Ser Leu Met Tyr Leu Arg Phe Ser Asp Thr Tyr Pro Pro
             255                 260                 265

 gtt ttg gac aca gcc att gca ctg atg ttt act gta ctt gct cca ttc      866
 Val Leu Asp Thr Ala Ile Ala Leu Met Phe Thr Val Leu Ala Pro Phe
         270                 275                 280

 ttc aat ccc atc att tat agc ctg aga aac aag gac atg aac aat gcg      914
 Phe Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Met Asn Asn Ala
     285                 290                 295

 att aaa aaa ctg ttc tgt ctt caa aaa gtg ttg aac aag cct gga ggt      962
 Ile Lys Lys Leu Phe Cys Leu Gln Lys Val Leu Asn Lys Pro Gly Gly
 300                 305                 310                 315

 taa                                                                  965
 






      <210> 216
      <211> 4843
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (376)..(1212)

      <400> 216
 cataaaagag tcgctggggt tcctcagtca ccccacaagg cagcatgaca ccttggctgg     60

 gggaggctgg gctgagagtc tgggtagctt tgtcttcctg gctggtgggt cgaaggccag    120

 ggccacagca gtgggtgaga gggaagagct gaagtcggct gagggggcag tccagtaggc    180

 tctgggcaaa caggtcagca gagagcaagc tcccgggttg ggtcaccggc tccccatcct    240

 ctggttggaa cacatcatcc tccagctcct ccacacactg agatggctcc atctctcctg    300

 tgcagggagc agagggaggc ttggtgactg gatcattggg tgcacactga gatttacgaa    360

 cggtaggcat gagag atg gag cca tct cag tgt gtg gag gag ctg gag gat     411
                  Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp
                    1               5                  10

 gat gtg ttc caa cca gag gat ggg gag ccg gtg acc caa ccc ggg agc      459
 Asp Val Phe Gln Pro Glu Asp Gly Glu Pro Val Thr Gln Pro Gly Ser
          15                  20                  25

 ttg ctc tct gct gac ctg ttt gcc cag agc cta ctg gac tgc ccc ctc      507
 Leu Leu Ser Ala Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu
      30                  35                  40

 agc cga ctt cag ctc ttc cct ctc acc cac tgc tgt ggc cct ggc ctt      555
 Ser Arg Leu Gln Leu Phe Pro Leu Thr His Cys Cys Gly Pro Gly Leu
  45                  50                  55                  60

 cga ccc acc agc cag gaa gac aaa gct acc cag act ctc agc cca gcc      603
 Arg Pro Thr Ser Gln Glu Asp Lys Ala Thr Gln Thr Leu Ser Pro Ala
                  65                  70                  75

 tcc ccc agc caa ggt gtc atg ctg cct tgt ggg gtg act gag gaa ccc      651
 Ser Pro Ser Gln Gly Val Met Leu Pro Cys Gly Val Thr Glu Glu Pro
              80                  85                  90

 cag cga ctc ttt tat ggc aat gct ggc tat cgg ctt cct ctc cct gcc      699
 Gln Arg Leu Phe Tyr Gly Asn Ala Gly Tyr Arg Leu Pro Leu Pro Ala
          95                 100                 105

 agt ttc cca gca gtc ttg ccc att ggg gag cag ccc ccc gaa ggg cag      747
 Ser Phe Pro Ala Val Leu Pro Ile Gly Glu Gln Pro Pro Glu Gly Gln
     110                 115                 120

 tgg caa cat caa gca gag gta cag att gcc cga aag ctt cag tgc att      795
 Trp Gln His Gln Ala Glu Val Gln Ile Ala Arg Lys Leu Gln Cys Ile
 125                 130                 135                 140

 gca gac cag ttc cac cgg ctt cat gtg cag caa cac cag cag aac caa      843
 Ala Asp Gln Phe His Arg Leu His Val Gln Gln His Gln Gln Asn Gln
                 145                 150                 155

 aat cgt gtg tgg tgg cag atc ctc ctc ttc ctg cac aac ctt gct ttg      891
 Asn Arg Val Trp Trp Gln Ile Leu Leu Phe Leu His Asn Leu Ala Leu
             160                 165                 170

 aat gga gaa gag aac agg aac ggg gca ggg ccc gta ggt gag ggt ggg      939
 Asn Gly Glu Glu Asn Arg Asn Gly Ala Gly Pro Val Gly Glu Gly Gly
         175                 180                 185

 ctg ccc tct tca cat ggg gca cca gga aca ccg tct gga aca gga agg      987
 Leu Pro Ser Ser His Gly Ala Pro Gly Thr Pro Ser Gly Thr Gly Arg
     190                 195                 200

 aca tcg ggc agg act gac act gtg tct tgt gaa att gtt ttt ttg ttg     1035
 Thr Ser Gly Arg Thr Asp Thr Val Ser Cys Glu Ile Val Phe Leu Leu
 205                 210                 215                 220

 tta ttt tgt gtt tta att ttt ttt aat ttc tct ctg agt gta cat aca     1083
 Leu Phe Cys Val Leu Ile Phe Phe Asn Phe Ser Leu Ser Val His Thr
                 225                 230                 235

 aca tac tca agc ggg acc ttc ttt ctc tgt cag gcc ctt gac ctg gaa     1131
 Thr Tyr Ser Ser Gly Thr Phe Phe Leu Cys Gln Ala Leu Asp Leu Glu
             240                 245                 250

 tgg ggg cct ttg tca aac act gtt gaa gga gag gct gat gtg tct gtg     1179
 Trp Gly Pro Leu Ser Asn Thr Val Glu Gly Glu Ala Asp Val Ser Val
         255                 260                 265

 atg gtg aga att ccc aag ggc tct gac aag tag attcttcg actgaggaat     1230
 Met Val Arg Ile Pro Lys Gly Ser Asp Lys 
     270                 275

 ctaccagttg tcgaagatga tccgttagtg atgttctctg ggaagtggac tgtggttttt   1290

 ccagaggaac tcagttaaga aatcgagagt ggattagact cccagttcca ccaaacctat   1350

 gagccttcca ctgtggatgg gggccgtgat cctgatggtc acattgcttt aacccagcag   1410

 ggcttcggcc aggggctttc cacttgagga tagcagcttc actagggctg ggccggccag   1470

 ctccacatct gactgggttc ttacttctca gccagtacct gccccatggg ctcaaggatt   1530

 cctggccagc tcctgccacc tccagcagac ctcagggagg gttgggtttc tctaaggacc   1590

 cctcaaacat gtcgcaaaat gaaccaaact tctggctagg cctcaaaact gacttggtcc   1650

 cacttggagg ccccaggatt ggtcctgagg tacagagcca ctgccaccac tggcggcctg   1710

 ggaccagctg ggtgtcagcc acggatgagc cgaatagcca gtcagcatgt tgctgctggc   1770

 agcctgtgcc tttgtcagct cttctttcaa aagaccccac cgacagaccg cattccaccc   1830

 ccaacatcgg cactgaggga catcgggggc aagtttgcag tggggccgga aaatatggtg   1890

 gccaccctac catgagagtc agccgtaggg gaccccagac cccttggttt ccttggaaac   1950

 aacatacctc ttccccctta tccccagtcc tttttcatac ctagtgggat acagaagaag   2010

 ccaggacagt ggctttgcca gctaagtgac ttttagagta acagataacg attagagtgg   2070

 ggaaccgtca aagctgggta cacatttcct atcttcctcc agcttccagc taggccagaa   2130

 gggcatgctc tggaacccag caggatcaca gctgcctgtg cacgtcttcc cttctctccc   2190

 tgctgcggca cttatggaga ggatctaaag cagccggtgt ggcagctccg atagcaggca   2250

 cagggaatct gttaaccaga cgctagaaac taaattataa cttttgcata tgtgagaaaa   2310

 gacaacattg gtgctaacag tgaagtaagg cccaaaggaa agacggcttc cctggacaaa   2370

 gaagacctca gggctaccca aggaaatagg aggagtctag agtagactca caaatctgaa   2430

 caagcccaag tcttccagtt ctgaggagag gaggtcttca gtactattga aggagacatt   2490

 gatcttctgg atgtacagtt gtgcaggttg ttcactgcac aagggcacct gcagctaatg   2550

 gaggctggaa ttcagcttgt gttctgctca ctaagctgtg tgcgtgccct ggtgtggggc   2610

 tacttctccc aagaagaagg ggtgcctttc ctaatttgca aaggtgccat atgggctcac   2670

 agcaccctgg aggagaaggg cctcaaactg tgcatgtaag cctttgtttt gttctgctca   2730

 gatattctgg atattacctc ttcttggtca gaattctatt ctcagggtgt gtaccatgat   2790

 ttgtctgcta agaagacggg ttcctgcttt gcagagaagg agccggggac cagcttgaag   2850

 actggctctg ggacacactg accattgtga aattcagcct tccctgtggg tctccatacc   2910

 attttatgat gtgtatggga catacgttgt tctcccctct ctggatcaag gtggtgacag   2970

 gcagcctgct gccgtatgct tcagtggcac acaccaaaaa aaccgggatt atttacagca   3030

 gccactattc accccttttg gcagactctc cacctgagtt cagtgagaga gaaaatgatt   3090

 tagatcttgg tgctggggca aggccatcag cttcagagac cttgccaggc ccaggctggg   3150

 tgccctgtgg cctgagaact gagcccagac tttgacaaac ccacctcaac atcaagcctg   3210

 gggcaggtgg aaggtggtct gactgcactg tctccatctt atgcaaagcc aggaactcac   3270

 tcactgtctt aagtgagcca gggcaaaatt tacacccctc acgtttccct ctcccttctt   3330

 ccccaccaac aaaacccagg aggtagctgg cagagtagct gtcaggaagg agaaaggttc   3390

 tttctggctg gttgttttta attggcttag tgatctaaac tggccccttc ctcctctgcc   3450

 tggtgagttg gcctaaacat tcctcaagtc tagcctcagg agacctgccc ctcccccccg   3510

 acctccaccc cctcagactc catcccccac ccccaggagc ctggctgtct ctagcgaggg   3570

 gtggagaatc agatttagag ggagggagag tctgacctgg atcctgacct gtaaccagct   3630

 gaagacggtg gaggctttgt ggcttgctga gggtgggggt tgggagaggg actggaaacc   3690

 ttcctcctcg ggaaagaaat gcctgggagg aagggaagcc tgatattcag ggtcaaaaca   3750

 gcccttctaa ttcacaaccc caaagcaggg gtttctagaa gttggtcaac agatctggtg   3810

 agggaagtcc ccaggccaga cgctggactc ctgcaatgag ggtggaggac tcagcctggc   3870

 ctctgcctgg cctgtttcaa agtctgggcc actggcagcc ttctcttgct caatccgagg   3930

 tggaaaaaga tcacctccca gtgacctccc tcagccccca ggggagtagg tctgtgtcca   3990

 aagctatgtg gcaggcttgt ttgaaggacc cagaggggcc cagctgacct gtctcactgc   4050

 tcctggcagc ccagccccat cggcaggtgg cccctgcctg ggggttattc gggatggttc   4110

 agccagggcc tcccaggaag agtgctgtgg agccacggtg actgtcctgg acagcaagga   4170

 gcatgctacc ccagtgagca cttctttttg agggacttga tggggaggtg gggtaggcag   4230

 aagggacgtg gcagaagcgg gaagactttg gtcaccatgg ctctgcaggc cttctgcaaa   4290

 tcagtgctgg cctgggctgg aaacagctct gtgtgtgaag gtgaggactc ttggaagcag   4350

 gccatcctgg ccagacaccc tagcaggaag gggctcacct gtcaccctta ggcagcctga   4410

 gggctggtgg ggacttttga gtcttgaggg gatagcggaa aaagctgagc tcataggtgc   4470

 ccagccagcc tcccagctaa aggtgctcag agccccactg ccccctctct ctgtgcaggt   4530

 ggccagtgcc cctccctgct ctgggagcat tgctagcctt ctaccccatc cctggatcca   4590

 caggggctat cgaggagacc cagtgagaat gtagcatttt gttcatcccc agggtagctg   4650

 ccctggggtc tgggcactct gcctctggga gagaggaaga agaaaggggc cccatttttt   4710

 aaaaaactgt acagagcctt tggctttatg tgtttatgtt cttcacatgc atatgtgtgt   4770

 atgtgtgtat atctttcccc ccatcaattg gtacaatttt taataaaatc atttaaagca   4830

 aaaaaaaaaa aaa                                                      4843




      <210> 217
      <211> 1191
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1191)

      <400> 217
  atg tcc tcc att cct cac tca gtt gac acg aag gca ctg ggg cct gaa      48
  Met Ser Ser Ile Pro His Ser Val Asp Thr Lys Ala Leu Gly Pro Glu
    1               5                  10                  15

 gga cac gga aca gga ata gct gca gtt gct tcc tac ctg cag gca att       96
 Gly His Gly Thr Gly Ile Ala Ala Val Ala Ser Tyr Leu Gln Ala Ile
              20                  25                  30

 gct ggg gcc gaa gaa gct gct cgg gct cag gca cct gag cat ccc aaa      144
 Ala Gly Ala Glu Glu Ala Ala Arg Ala Gln Ala Pro Glu His Pro Lys
          35                  40                  45

 ggg atc acc tgc tgg atc gcc ctg tat gct gtg gag gcc ctc ccc acc      192
 Gly Ile Thr Cys Trp Ile Ala Leu Tyr Ala Val Glu Ala Leu Pro Thr
      50                  55                  60

 tgc cct ttc tcc tgc aag tgt gac agc cgc agc ctg gag gtg gac tgc      240
 Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg Ser Leu Glu Val Asp Cys
  65                  70                  75                  80

 agt ggc ctt ggc ctc acc acg gtg ccc cca gac gtg ccc gca gcc acc      288
 Ser Gly Leu Gly Leu Thr Thr Val Pro Pro Asp Val Pro Ala Ala Thr
                  85                  90                  95

 cga acc ctc ttg ctc ttg aac aat aag ctg agt gcc ctg cca agc tgg      336
 Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu Ser Ala Leu Pro Ser Trp
             100                 105                 110

 gct ttc gcc aac ctc tcc agc ctg cag cgg ttg gac ctg tcc aac aac      384
 Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg Leu Asp Leu Ser Asn Asn
         115                 120                 125

 ttc ctg gac cgg ctg ccc cgc tcc att ttc ggg gac ctg acg aat ctg      432
 Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe Gly Asp Leu Thr Asn Leu
     130                 135                 140

 act gag ctt cag ctg cgc aat aac agc atc agg acc ctg gac agg gac      480
 Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile Arg Thr Leu Asp Arg Asp
 145                 150                 155                 160

 ctg ctg cgg cac tcg ccg ctg ctc cgc cac ctg gac ctg tcc atc aac      528
 Leu Leu Arg His Ser Pro Leu Leu Arg His Leu Asp Leu Ser Ile Asn
                 165                 170                 175

 ggc ctg gcc cag ttg ccc cct ggt ctt ttc gac ggg ctc ctg gct ctg      576
 Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe Asp Gly Leu Leu Ala Leu
             180                 185                 190

 cgc tcc ctc tcg ctt cgc tcc aac cgt ctg cag aat ctg gac cgg ctg      624
 Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu Gln Asn Leu Asp Arg Leu
         195                 200                 205

 aca ttt gaa ccc cta gca aac ctg cag ctg ctg cag gtc ggg gat aac      672
 Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu Leu Gln Val Gly Asp Asn
     210                 215                 220

 ccc tgg gag tgt gac tgt aac ctg cgt gag ttc aaa cac tgg atg gag      720
 Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu Phe Lys His Trp Met Glu
 225                 230                 235                 240

 tgg ttc tcc tac cga ggg gga cgc ttg gac cag ctt gcc tgc acc ctg      768
 Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp Gln Leu Ala Cys Thr Leu
                 245                 250                 255

 ccc aag gag ctg agg ggg aag gac atg cgg atg gtc ccc atg gag atg      816
 Pro Lys Glu Leu Arg Gly Lys Asp Met Arg Met Val Pro Met Glu Met
             260                 265                 270

 ttc aac tac tgc tcc cag ctg gag gac gag aat agc tca gct ggg ctg      864
 Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu Asn Ser Ser Ala Gly Leu
         275                 280                 285

 gat att cct ggg cca ccc tgc acc aag gcc agt cca gag cct gct aag      912
 Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala Ser Pro Glu Pro Ala Lys
     290                 295                 300

 ccc aag ccc ggg gtt gag ccg gag ccg gag ccc agc aca gcc tgc cca      960
 Pro Lys Pro Gly Val Glu Pro Glu Pro Glu Pro Ser Thr Ala Cys Pro
 305                 310                 315                 320

 cag aag cag agg cac cgg ccg gcg agc gtg agg cga gcc atg ggc acg     1008
 Gln Lys Gln Arg His Arg Pro Ala Ser Val Arg Arg Ala Met Gly Thr
                 325                 330                 335

 gtg atc att gca ggg gtc gtg tgc ggc gtc gtc tgc atc atg atg gtg     1056
 Val Ile Ile Ala Gly Val Val Cys Gly Val Val Cys Ile Met Met Val
             340                 345                 350

 gtg gcc gct gcc tat ggc tgc atc tac gcc tcc ctc atg gcc aag tac     1104
 Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala Ser Leu Met Ala Lys Tyr
         355                 360                 365

 cac cgg gag ctc aaa aag cgc cag ccc ctg atg ggg gac ccc gag ggc     1152
 His Arg Glu Leu Lys Lys Arg Gln Pro Leu Met Gly Asp Pro Glu Gly
     370                 375                 380

 gag cac gag gac cag aag cag atc tct tct gtg gcc tga                 1191
 Glu His Glu Asp Gln Lys Gln Ile Ser Ser Val Ala 
 385                 390                 395





      <210> 218
      <211> 1431
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (283)..(1431)

      <400> 218
 aagagggcca ctctacctct cttgctgcca gccttcactc cagcaaggag ggtgctgggt     60

 gacctgagcc cacatagcct cgagcacccg aagcacacac agcagagtcc tctggacttt    120

 gaggaagaac ccacagcagg aggaagtcag cagggagtgg ctgtgtgaaa cctgggacca    180

 cttctgcctt cctacgtggc agtggctcag agttatttga gtgctgtcaa actgagctga    240

 ttgctgccct agtattagat cagtccatag aaagtgggag ca   atg gca ctg aca     294
                                                  Met Ala Leu Thr
                                                    1

 ctg cta gag gat tgg tgc aag ggg atg gac atg gac ccc aga aag gcc      342
 Leu Leu Glu Asp Trp Cys Lys Gly Met Asp Met Asp Pro Arg Lys Ala
   5                  10                  15                  20

 ctg ctg att gta ggc atc ccc atg gag tgt agt gag gtg gaa att cag      390
 Leu Leu Ile Val Gly Ile Pro Met Glu Cys Ser Glu Val Glu Ile Gln
                  25                  30                  35

 gac act gtg aag gca ggc tta cag ccc ctg tgc gca tac agg gtc cta      438
 Asp Thr Val Lys Ala Gly Leu Gln Pro Leu Cys Ala Tyr Arg Val Leu
              40                  45                  50

 ggg aga atg ttc agg agg gaa gac aat gcc aag gca gtc ttc att gaa      486
 Gly Arg Met Phe Arg Arg Glu Asp Asn Ala Lys Ala Val Phe Ile Glu
          55                  60                  65

 ctg gct gac act gtc aat tac act act ctg ccc agt cac ata cca gga      534
 Leu Ala Asp Thr Val Asn Tyr Thr Thr Leu Pro Ser His Ile Pro Gly
      70                  75                  80

 aag ggt ggc tcc tgg gaa gtg gtg gta aaa ccc cgt aac cca gat gat      582
 Lys Gly Gly Ser Trp Glu Val Val Val Lys Pro Arg Asn Pro Asp Asp
  85                  90                  95                 100

 gag ttt ctc agt aga ctg aac tac ttc ctg aaa gat gag ggc cga agt      630
 Glu Phe Leu Ser Arg Leu Asn Tyr Phe Leu Lys Asp Glu Gly Arg Ser
                 105                 110                 115

 atg aca gat gtg gcc aga gcc ctg gga tgt tgc agc ctc cct gcc gag      678
 Met Thr Asp Val Ala Arg Ala Leu Gly Cys Cys Ser Leu Pro Ala Glu
             120                 125                 130

 agc ctg gat gca gag gtc atg ccc caa gtt aga tcc cca cct tta gag      726
 Ser Leu Asp Ala Glu Val Met Pro Gln Val Arg Ser Pro Pro Leu Glu
         135                 140                 145

 cct ccg aaa gaa agc gaa gag acc ttt gaa gac tgg cta gag cag gtc      774
 Pro Pro Lys Glu Ser Glu Glu Thr Phe Glu Asp Trp Leu Glu Gln Val
     150                 155                 160

 act gag ata atg ccc ata tgg caa gtg tct gag gtg gag aag agg cgg      822
 Thr Glu Ile Met Pro Ile Trp Gln Val Ser Glu Val Glu Lys Arg Arg
 165                 170                 175                 180

 cgt ttg ctg gag agc tta cgt ggg cct gct ctg tca atc atg cgg gtg      870
 Arg Leu Leu Glu Ser Leu Arg Gly Pro Ala Leu Ser Ile Met Arg Val
                 185                 190                 195

 ctc cag gcc aac aat gac tcc ata act gtg gag cag tgc ctt gac gcc      918
 Leu Gln Ala Asn Asn Asp Ser Ile Thr Val Glu Gln Cys Leu Asp Ala
             200                 205                 210

 cta aag cag atc ttt ggg gat aaa gag gac ttt aga gcc tct cag ttt      966
 Leu Lys Gln Ile Phe Gly Asp Lys Glu Asp Phe Arg Ala Ser Gln Phe
         215                 220                 225

 agg ttt ctg cag acc tct ccg aag att gga gag aaa gtc tcc act ttc     1014
 Arg Phe Leu Gln Thr Ser Pro Lys Ile Gly Glu Lys Val Ser Thr Phe
     230                 235                 240

 ctg ctg cgc tta gag ccc ctg ctg cag aaa gcc gtg cac aag agc ccc     1062
 Leu Leu Arg Leu Glu Pro Leu Leu Gln Lys Ala Val His Lys Ser Pro
 245                 250                 255                 260

 ttg tca gtg cgc agc aca gac atg att cgt ctg aaa cat ctc tta gct     1110
 Leu Ser Val Arg Ser Thr Asp Met Ile Arg Leu Lys His Leu Leu Ala
                 265                 270                 275

 cgg gtc gcc atg acc ccc gcc ctc agg ggc aag ctg gag ctc ttg gat     1158
 Arg Val Ala Met Thr Pro Ala Leu Arg Gly Lys Leu Glu Leu Leu Asp
             280                 285                 290

 cag cga ggg tgt cct ccc aat ttt ctg gag tta atg aag ctc att cga     1206
 Gln Arg Gly Cys Pro Pro Asn Phe Leu Glu Leu Met Lys Leu Ile Arg
         295                 300                 305

 gat gaa gaa gag tgg gag aac act gag gca gtg atg aag aat aag gag     1254
 Asp Glu Glu Glu Trp Glu Asn Thr Glu Ala Val Met Lys Asn Lys Glu
     310                 315                 320

 aag cca tca ggg aga ggc cgg ggg gcc tcc ggc tca tct gag aac ctg     1302
 Lys Pro Ser Gly Arg Gly Arg Gly Ala Ser Gly Ser Ser Glu Asn Leu
 325                 330                 335                 340

 tcg att cac tac ctt gta agg atc cag cac cct ctg tgg cct ttc tgg     1350
 Ser Ile His Tyr Leu Val Arg Ile Gln His Pro Leu Trp Pro Phe Trp
                 345                 350                 355

 act ccc gac gtc cac ctg ttc ctg gcc tgg gat cac ctc ctc ttg ttc     1398
 Thr Pro Asp Val His Leu Phe Leu Ala Trp Asp His Leu Leu Leu Phe
             360                 365                 370

 atc tgc atc tca tta ttg ggc cac aag aaa tag                         1431
 Ile Cys Ile Ser Leu Leu Gly His Lys Lys 
         375                 380





      <210> 219
      <211> 1811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (158)..(1318)

      <400> 219
 cgaggcggct acgcgtgcgc ggtgggcgga gcgcggctct cctaccttct cgggcagccc     60

 agtctttgcc atccttgccc agccggtgtg gtgcttgtgt gtcacagcct tgtagccggg    120

 agtcgctgcc gagtgggcgc tcagttttcg ggtcgtc atg gct ggc tac gaa tac     175
                                          Met Ala Gly Tyr Glu Tyr
                                            1               5

 gtg agc ccg gag cag ctg gct ggc ttt gat aag tac aag tac agt gct      223
 Val Ser Pro Glu Gln Leu Ala Gly Phe Asp Lys Tyr Lys Tyr Ser Ala
              10                  15                  20

 gtg gat acc aat cca ctt tct ctg tat gtc atg cat cca ttc tgg aac      271
 Val Asp Thr Asn Pro Leu Ser Leu Tyr Val Met His Pro Phe Trp Asn
          25                  30                  35

 act ata gta aag gta ttt cct act tgg ctg gcg ccc aat ctg ata act      319
 Thr Ile Val Lys Val Phe Pro Thr Trp Leu Ala Pro Asn Leu Ile Thr
      40                  45                  50

 ttt tct ggc ttt ctg ctg gtc gta ttc aat ttt ctg cta atg gca tac      367
 Phe Ser Gly Phe Leu Leu Val Val Phe Asn Phe Leu Leu Met Ala Tyr
  55                  60                  65                  70

 ttt gat cct gac ttt tat gcc tca gca cca ggt cac aag cac gtg cct      415
 Phe Asp Pro Asp Phe Tyr Ala Ser Ala Pro Gly His Lys His Val Pro
                  75                  80                  85

 gac tgg gtt tgg att gta gtg ggc atc ctc aac ttc gta gcc tac act      463
 Asp Trp Val Trp Ile Val Val Gly Ile Leu Asn Phe Val Ala Tyr Thr
              90                  95                 100

 cta gat ggt gtg gac gga aag caa gct cgc aga acc aat tct agc act      511
 Leu Asp Gly Val Asp Gly Lys Gln Ala Arg Arg Thr Asn Ser Ser Thr
         105                 110                 115

 ccc tta ggg gag ctt ttt gat cat ggc ctg gat agt tgg tca tgt gtt      559
 Pro Leu Gly Glu Leu Phe Asp His Gly Leu Asp Ser Trp Ser Cys Val
     120                 125                 130

 tac ttt gtt gtg act gtt tat tcc atc ttt gga aga gga tca act ggt      607
 Tyr Phe Val Val Thr Val Tyr Ser Ile Phe Gly Arg Gly Ser Thr Gly
 135                 140                 145                 150

 gtc agt gtt ttt gtt ctt tat ctc ctg cta tgg gta gtt ttg ttt tct      655
 Val Ser Val Phe Val Leu Tyr Leu Leu Leu Trp Val Val Leu Phe Ser
                 155                 160                 165

 ttc atc ctg tcc cac tgg gaa aag tat aac aca ggg att ctt ttc ctg      703
 Phe Ile Leu Ser His Trp Glu Lys Tyr Asn Thr Gly Ile Leu Phe Leu
             170                 175                 180

 cca tgg gga tat gac att agc cag gtg act att tct ttt gtc tac ata      751
 Pro Trp Gly Tyr Asp Ile Ser Gln Val Thr Ile Ser Phe Val Tyr Ile
         185                 190                 195

 gtg act gca gtt gtg gga gtt gag gcc tgg tat gaa cct ttc ctg ttt      799
 Val Thr Ala Val Val Gly Val Glu Ala Trp Tyr Glu Pro Phe Leu Phe
     200                 205                 210

 aat ttc tta tat aga gac cta ttc act gca atg att att ggt tgt gca      847
 Asn Phe Leu Tyr Arg Asp Leu Phe Thr Ala Met Ile Ile Gly Cys Ala
 215                 220                 225                 230

 tta tgt gtg act ctt cca atg agt tta tta aac ttt ttc aga agc tat      895
 Leu Cys Val Thr Leu Pro Met Ser Leu Leu Asn Phe Phe Arg Ser Tyr
                 235                 240                 245

 aaa aat aac acc ttg aaa ctc aat tca gtc tat gaa gct atg gtt ccc      943
 Lys Asn Asn Thr Leu Lys Leu Asn Ser Val Tyr Glu Ala Met Val Pro
             250                 255                 260

 tta ttt tct cca tgc ttg ctg ttc att ttg tct aca gcg tgg atc ctt      991
 Leu Phe Ser Pro Cys Leu Leu Phe Ile Leu Ser Thr Ala Trp Ile Leu
         265                 270                 275

 tgg tca cct tca gat att tta gag cta cat cct aga gta ttc tac ttt     1039
 Trp Ser Pro Ser Asp Ile Leu Glu Leu His Pro Arg Val Phe Tyr Phe
     280                 285                 290

 atg gtt gga aca gcc ttt gcc aac agt aca tgt cag ctg att gtt tgc     1087
 Met Val Gly Thr Ala Phe Ala Asn Ser Thr Cys Gln Leu Ile Val Cys
 295                 300                 305                 310

 caa atg agt agt acc cgg tgt cca act ttg aat tgg ttg ctg gtt cct     1135
 Gln Met Ser Ser Thr Arg Cys Pro Thr Leu Asn Trp Leu Leu Val Pro
                 315                 320                 325

 ctc ttc ttg gtt gtc tta gtg gta aac cta gga gta gcc tct tac gtt     1183
 Leu Phe Leu Val Val Leu Val Val Asn Leu Gly Val Ala Ser Tyr Val
             330                 335                 340

 gag agc att ctc ctg tat aca tta aca act gct ttt act ctg gcc cac     1231
 Glu Ser Ile Leu Leu Tyr Thr Leu Thr Thr Ala Phe Thr Leu Ala His
         345                 350                 355

 atc cat tat gga gta cga gtg gta aag cag ctg agc agc cat ttt cag     1279
 Ile His Tyr Gly Val Arg Val Val Lys Gln Leu Ser Ser His Phe Gln
     360                 365                 370

 att tac ccc ttc tca ttg agg aaa cca aac tca gat tga ctaggaatgg      1328
 Ile Tyr Pro Phe Ser Leu Arg Lys Pro Asn Ser Asp 
 375                 380                 385

 aagaaaagaa tattggcctg taataatctt tctttgggca caaagaagta ctgtaaataa   1388

 atgcttgtaa atatttcctc catcaccatt gaactagact gatctgcttg acagacgtgg   1448

 gatctcagta tggtacttgg acagcaggaa tgatacatat aatctgaact tgggaaattt   1508

 tggacctact aactctaagc ctattttatt ttttataaaa ctatgtgaca ttttggttga   1568

 gcagaatgta cgttagacca gcaaaatgtt cctaatggtt ctaacttcgt gagtttacaa   1628

 tgttgtgatt catgcagggt taaagatgct ttgtttttat tttttaagta ccaaaattgg   1688

 tttcagaaca ctgataacac tcagaaaacc acagtgtgtt ttcatatttg gaactttgta   1748

 atagcgggag tagcagtagt ccaaacctag tatagggaaa ggataaaaat aagtcacctt   1808

 cac                                                                 1811




      <210> 220
      <211> 776
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(729)

      <400> 220
  atg cga cag ctg gag aac gct ggg cag cac cac acc ctc caa ttc aca      48
  Met Arg Gln Leu Glu Asn Ala Gly Gln His His Thr Leu Gln Phe Thr
    1               5                  10                  15

 ctg cct tct agt tgt gcc aac tgg aac cac cct ttg gct gtg ctg cga       96
 Leu Pro Ser Ser Cys Ala Asn Trp Asn His Pro Leu Ala Val Leu Arg
              20                  25                  30

 aat gga ccc cag tgt tgt tgt ggg tgt gtc aaa tcc cct ttc atc ctc      144
 Asn Gly Pro Gln Cys Cys Cys Gly Cys Val Lys Ser Pro Phe Ile Leu
          35                  40                  45

 aag agc tcc ctg ctt ccc tta gat tat ttc aat acg gtg ata tcc tta      192
 Lys Ser Ser Leu Leu Pro Leu Asp Tyr Phe Asn Thr Val Ile Ser Leu
      50                  55                  60

 ttt gct agc aga aaa ggg act aac gtc ccc att cct ctt ttc tgc tgc      240
 Phe Ala Ser Arg Lys Gly Thr Asn Val Pro Ile Pro Leu Phe Cys Cys
  65                  70                  75                  80

 gtc cca ctg gct cag aga agc aag gcg gtg cgc ggt tgg gca gaa acc      288
 Val Pro Leu Ala Gln Arg Ser Lys Ala Val Arg Gly Trp Ala Glu Thr
                  85                  90                  95

 tgg gag gag tct cca agc cca att cac agc aca caa cgg cag tgc aca      336
 Trp Glu Glu Ser Pro Ser Pro Ile His Ser Thr Gln Arg Gln Cys Thr
             100                 105                 110

 caa aga aat gac atg gaa ata gat gca ggc agg ctg gtc cct gct gtg      384
 Gln Arg Asn Asp Met Glu Ile Asp Ala Gly Arg Leu Val Pro Ala Val
         115                 120                 125

 att aac gag aac tcc aag tac aag gcc gac cac aat gga tgc tgc aaa      432
 Ile Asn Glu Asn Ser Lys Tyr Lys Ala Asp His Asn Gly Cys Cys Lys
     130                 135                 140

 aac gtt gac tgg ggc aaa gga ttt ttt att tta ttt ttt att ttg tta      480
 Asn Val Asp Trp Gly Lys Gly Phe Phe Ile Leu Phe Phe Ile Leu Leu
 145                 150                 155                 160

 att atg ttt tta ggg gat ggg agg tgg tgt gtg ttt ttc tcc tct tgg      528
 Ile Met Phe Leu Gly Asp Gly Arg Trp Cys Val Phe Phe Ser Ser Trp
                 165                 170                 175

 ttt tca ttt gct caa gca cac aaa agg gac ttt tgt tta ctc tat cat      576
 Phe Ser Phe Ala Gln Ala His Lys Arg Asp Phe Cys Leu Leu Tyr His
             180                 185                 190

 gaa caa agg aac tgt cca cat act gta aac cat gag cag tgt tgt tgt      624
 Glu Gln Arg Asn Cys Pro His Thr Val Asn His Glu Gln Cys Cys Cys
         195                 200                 205

 tgt ttt ttt aaa cag tat att tgg tgg tct ctt tgt ctg ctt tta ttt      672
 Cys Phe Phe Lys Gln Tyr Ile Trp Trp Ser Leu Cys Leu Leu Leu Phe
     210                 215                 220

 cca gtt cga tct tct ggg ttt agt ttt gtc ttt aaa aag aat tca aaa      720
 Pro Val Arg Ser Ser Gly Phe Ser Phe Val Phe Lys Lys Asn Ser Lys
 225                 230                 235                 240

 aaa gac tga caatgac agttttgagt tggatagtga aaaagtggag cctccataat      776
 Lys Asp 






      <210> 221
      <211> 1179
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(1136)

      <400> 221
 gaacagctgg tgcctccgag ggcggtcggc gagcgcgcgg gcgtggggcg ctggggggcc     60

 ggtcgggcag cgctgcggga gcagccgccg gcaccgccgc cttgcaccat cgcatc        116                                                                 
 atg tcc ggg cag ctg gag cgt tgc gag cgc gaa tgg cac gag ctg gag      164
 Met Ser Gly Gln Leu Glu Arg Cys Glu Arg Glu Trp His Glu Leu Glu
   1               5                  10                  15

 gga gaa ttt caa gaa ctg cag gag acg cac agg atc tac aag cag aag      212
 Gly Glu Phe Gln Glu Leu Gln Glu Thr His Arg Ile Tyr Lys Gln Lys
              20                  25                  30

 ctg gag gag ctg gct gcg ctg cag acg ctg tgt agc agt tcc atc agt      260
 Leu Glu Glu Leu Ala Ala Leu Gln Thr Leu Cys Ser Ser Ser Ile Ser
          35                  40                  45

 aag cag aag aag cac ctc aag gac ttg aag ctt aca ctc cag agg tgc      308
 Lys Gln Lys Lys His Leu Lys Asp Leu Lys Leu Thr Leu Gln Arg Cys
      50                  55                  60

 aaa cgc cat gcc agt cgg gag gag gcg gag ctc gtt cag cag atg gca      356
 Lys Arg His Ala Ser Arg Glu Glu Ala Glu Leu Val Gln Gln Met Ala
  65                  70                  75                  80

 gcg aac atc aag gag cgg cag gac gtc ttc ttc gac atg gag gcc tac      404
 Ala Asn Ile Lys Glu Arg Gln Asp Val Phe Phe Asp Met Glu Ala Tyr
                  85                  90                  95

 ctg ccc aag aag aac ggg ctc tac ttg aac ctg gtc ctc ggc aat gtg      452
 Leu Pro Lys Lys Asn Gly Leu Tyr Leu Asn Leu Val Leu Gly Asn Val
             100                 105                 110

 aac gtg acc ctc ctc agc aac cag gcc aag ttc gcc tac aag gac gaa      500
 Asn Val Thr Leu Leu Ser Asn Gln Ala Lys Phe Ala Tyr Lys Asp Glu
         115                 120                 125

 tat gag aag ttc aag ctc tac ctg acc atc atc ctg ctc ctg ggt gcc      548
 Tyr Glu Lys Phe Lys Leu Tyr Leu Thr Ile Ile Leu Leu Leu Gly Ala
     130                 135                 140

 gtg gca tgt cga ttt gtc ctt cac tac agg gtg act gac gaa gtc ttc      596
 Val Ala Cys Arg Phe Val Leu His Tyr Arg Val Thr Asp Glu Val Phe
 145                 150                 155                 160

 aac ttc ctg ctg gtg tgg tat tac tgc acc ctg acc att cgg gag agc      644
 Asn Phe Leu Leu Val Trp Tyr Tyr Cys Thr Leu Thr Ile Arg Glu Ser
                 165                 170                 175

 att ctc atc agc aac ggc tca aga att aaa ggc tgg tgg gtg tct cac      692
 Ile Leu Ile Ser Asn Gly Ser Arg Ile Lys Gly Trp Trp Val Ser His
             180                 185                 190

 cac tac gtc tcc aca ttc ctg tcc gga gtg atg ctg acc tgg cct aat      740
 His Tyr Val Ser Thr Phe Leu Ser Gly Val Met Leu Thr Trp Pro Asn
         195                 200                 205

 gga ccc att tat cag aag ttt cgc aac cag ttc tta gca ttt tcc att      788
 Gly Pro Ile Tyr Gln Lys Phe Arg Asn Gln Phe Leu Ala Phe Ser Ile
     210                 215                 220

 ttt cag agc tgc gtc cag ttc ctg caa tat tat tac cag agg ggc tgc      836
 Phe Gln Ser Cys Val Gln Phe Leu Gln Tyr Tyr Tyr Gln Arg Gly Cys
 225                 230                 235                 240

 ctc tac cgg ctg cgg gcc ctg ggg gag agg aac cac ctg gat ctc aca      884
 Leu Tyr Arg Leu Arg Ala Leu Gly Glu Arg Asn His Leu Asp Leu Thr
                 245                 250                 255

 gtg gaa ggg ttc cag tcc tgg atg tgg cgg ggc ctc acc ttt ctc ctg      932
 Val Glu Gly Phe Gln Ser Trp Met Trp Arg Gly Leu Thr Phe Leu Leu
             260                 265                 270

 ccc ttc ctc ttc tgt ggc cat ttc tgg cag ctc tac aat gcc gtc acg      980
 Pro Phe Leu Phe Cys Gly His Phe Trp Gln Leu Tyr Asn Ala Val Thr
         275                 280                 285

 ctg ttt gag ctc tcc agc cac gag gaa tgc aga gaa tgg cag gtg ttc     1028
 Leu Phe Glu Leu Ser Ser His Glu Glu Cys Arg Glu Trp Gln Val Phe
     290                 295                 300

 gta ctg gcg ttc acc ttc ctc atc ctc ttc ctc ggc aac ttc ctg acc     1076
 Val Leu Ala Phe Thr Phe Leu Ile Leu Phe Leu Gly Asn Phe Leu Thr
 305                 310                 315                 320

 acg ctc aaa gtc gtg cat gcc aag ctc cag aag aac aga ggc aag aca     1124
 Thr Leu Lys Val Val His Ala Lys Leu Gln Lys Asn Arg Gly Lys Thr
                 325                 330                 335

 aag cag ccg tga gcc tcgggctcct gtgccctcgg cccggacttc agactgcagg     1179
 Lys Gln Pro 






      <210> 222
      <211> 1724
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (324)..(1112)

      <400> 222
 tcagcgcact tggcgagctg gtgagtgtga gagggatact gcgagagggc taggggcggc     60

 cagtccgggg ctgccggcca aggctaggcg ctgccagccc gattctcctc tgctctccac    120

 ccccgcctca cccagtggcc ggcctggacc tgcaccccgc tgcttgaccc cgctcatcct    180

 ccccccgccc ggccgggcgc gctcctcccc ggccggcccc tcggcgcgcg gcgcgctgga    240

 ggcgaacgcg ggctgaggcg aacgctgggc tgagccgagc gcagtggcct gccgaccacc    300

 gagcgccccg cgccgctccc tgc    atg tgc ggc ccg cgg cgg ctc gca gct     350
                              Met Cys Gly Pro Arg Arg Leu Ala Ala
                                1               5

 ccc ggc agc agc ctc ggc agc ttc ggc cgc gcc tcg aga ggc ggc cgc      398
 Pro Gly Ser Ser Leu Gly Ser Phe Gly Arg Ala Ser Arg Gly Gly Arg
  10                  15                  20                  25

 aga ggc tcc agc ggc ggc cga gcg gcc gag ccc ggg ctg gga gac acc      446
 Arg Gly Ser Ser Gly Gly Arg Ala Ala Glu Pro Gly Leu Gly Asp Thr
                  30                  35                  40

 atg cgc cgc gtc ctt cgg ctg ctc ctc ggt tgc ttc ctc acc gag ctg      494
 Met Arg Arg Val Leu Arg Leu Leu Leu Gly Cys Phe Leu Thr Glu Leu
              45                  50                  55

 tgc gcc cgc gtg tgc cgg gcg cag gag cga gcg gga cac ggg cag ctg      542
 Cys Ala Arg Val Cys Arg Ala Gln Glu Arg Ala Gly His Gly Gln Leu
          60                  65                  70

 gcg caa ctg ggc ggc gtg ttg ctg ctg gcg ggg ggc aac cgc tcc ggg      590
 Ala Gln Leu Gly Gly Val Leu Leu Leu Ala Gly Gly Asn Arg Ser Gly
      75                  80                  85

 gcc gcc tcc gga gag gcc agc gag ggc gct gag gca tcg gac gcg ccc      638
 Ala Ala Ser Gly Glu Ala Ser Glu Gly Ala Glu Ala Ser Asp Ala Pro
  90                  95                 100                 105

 ccg acc cgg gcg ccc acg ccg gac ttc tgc cgg ggc tac ttc gat gtc      686
 Pro Thr Arg Ala Pro Thr Pro Asp Phe Cys Arg Gly Tyr Phe Asp Val
                 110                 115                 120

 atg ggc cag tgg gac ccg ccg ttc aac tgc agc tcg ggc gac ttc atc      734
 Met Gly Gln Trp Asp Pro Pro Phe Asn Cys Ser Ser Gly Asp Phe Ile
             125                 130                 135

 ttc tgc tgc ggg act tgt ggc ttc cgg ttc tgc tgc acg ttt aag aag      782
 Phe Cys Cys Gly Thr Cys Gly Phe Arg Phe Cys Cys Thr Phe Lys Lys
         140                 145                 150

 cgg cga ctg aac caa agc acc tgc acc aac tac gac acg ccg ctc tgg      830
 Arg Arg Leu Asn Gln Ser Thr Cys Thr Asn Tyr Asp Thr Pro Leu Trp
     155                 160                 165

 ctc aac acc ggc aag ccc ccc gcc cgc aag gac gac ccc ttg cac gac      878
 Leu Asn Thr Gly Lys Pro Pro Ala Arg Lys Asp Asp Pro Leu His Asp
 170                 175                 180                 185

 ccc acc aag gac aag acc aac ctg atc gtc tac atc atc tgc ggg gtg      926
 Pro Thr Lys Asp Lys Thr Asn Leu Ile Val Tyr Ile Ile Cys Gly Val
                 190                 195                 200

 gtg gcc gtc atg gtg ctc gtg ggc atc ttc acc aag ctg ggg ctg gag      974
 Val Ala Val Met Val Leu Val Gly Ile Phe Thr Lys Leu Gly Leu Glu
             205                 210                 215

 aaa gcg cac cgg ccc caa agg gag cac atg tcc agg ctc tat gac aat     1022
 Lys Ala His Arg Pro Gln Arg Glu His Met Ser Arg Leu Tyr Asp Asn
         220                 225                 230

 ctg ctg ttt acg gag gca cag att tct ttc caa gag gac gaa cct gcc     1070
 Leu Leu Phe Thr Glu Ala Gln Ile Ser Phe Gln Glu Asp Glu Pro Ala
     235                 240                 245

 cct gga gag tgg agt gtc gga ctt caa acc tgg aca gtc tga gtgcacg     1119
 Pro Gly Glu Trp Ser Val Gly Leu Gln Thr Trp Thr Val 
 250                 255                 260

 gatccttggc cgctaggctg cactgcgttt gagtgcaaac ctgcaggaat tccagacttc   1179

 tcagatcaca gagaagtacg cgatgccctg caaacaacag ctcatgcatc ggggccagtt   1239

 caagaagcta ccgtaagatg aagtctagga atgctttcta tatcggcccc ggcaggccca   1299

 gacgtcttgg tggaggcgtt ggtgagaaat gaccttgggg acagaagcac atatgtgaag   1359

 ctctctacat tgaagccagt agggaacaca tgtcattatt tgtccacctt caaaccagaa   1419

 ttggaaatcc aagtggcaca tggcccgata gggtcccgtg tgtttttaaa acatgcttcc   1479

 aaaagacctg gcacccttgg aagaaatagc accattatga taatggccct cctcctctgc   1539

 ttatggcttc agttctctcc tgcccccatt ttcatgcatg gggatctaag cttgccactc   1599

 ccgcggaaac ccgggtctct gtccacgtgc gcacgaaagt caaatttctg cggagtgcct   1659

 gccggtcgct tgaaacctgg gatataccac ccttgtgtct aaacagcgaa tacacacccc   1719

 tattg                                                               1724




      <210> 223
      <211> 5673
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4785)

      <400> 223
  atg cct aaa atc atc cag act gtt ggt ggt ggt gct gtg cag gag aga      48
  Met Pro Lys Ile Ile Gln Thr Val Gly Gly Gly Ala Val Gln Glu Arg
    1               5                  10                  15

 gcg cct gag ctg gat ggt ggt ggg ccc acg gag cag gac aaa agc cat       96
 Ala Pro Glu Leu Asp Gly Gly Gly Pro Thr Glu Gln Asp Lys Ser His
              20                  25                  30

 tct aac agc agc acc ttg tcg gac cga aga ctc agc aac tcc agc ctc      144
 Ser Asn Ser Ser Thr Leu Ser Asp Arg Arg Leu Ser Asn Ser Ser Leu
          35                  40                  45

 tgt agc att gaa gaa gag cac cga atg gtg tat gaa atg gta cag cgg      192
 Cys Ser Ile Glu Glu Glu His Arg Met Val Tyr Glu Met Val Gln Arg
      50                  55                  60

 att ctc ttg tca aca cga ggt tat gtc aac ttc gtg aat gaa gta ttt      240
 Ile Leu Leu Ser Thr Arg Gly Tyr Val Asn Phe Val Asn Glu Val Phe
  65                  70                  75                  80

 cac cag gca ttt ttg ttg cct tcc tgt gag ata gct gta aca aga aaa      288
 His Gln Ala Phe Leu Leu Pro Ser Cys Glu Ile Ala Val Thr Arg Lys
                  85                  90                  95

 gta gtt caa gtg tac aga aag tgg att ctc cag gac aaa cct gtg ttc      336
 Val Val Gln Val Tyr Arg Lys Trp Ile Leu Gln Asp Lys Pro Val Phe
             100                 105                 110

 atg gag gag cca gat aga aaa gat gtt gcc caa gaa gat gct gaa aaa      384
 Met Glu Glu Pro Asp Arg Lys Asp Val Ala Gln Glu Asp Ala Glu Lys
         115                 120                 125

 tta gga ttt tcc gag act gat agc aag gag gcc tca tct gaa agt tct      432
 Leu Gly Phe Ser Glu Thr Asp Ser Lys Glu Ala Ser Ser Glu Ser Ser
     130                 135                 140

 ggt cat aaa cga tct tcc agt tgg gga cgc aca tac tcc ttc aca agt      480
 Gly His Lys Arg Ser Ser Ser Trp Gly Arg Thr Tyr Ser Phe Thr Ser
 145                 150                 155                 160

 gca atg agc aga ggg tgt gtg aca gag gag gaa aat aca aat gtg aaa      528
 Ala Met Ser Arg Gly Cys Val Thr Glu Glu Glu Asn Thr Asn Val Lys
                 165                 170                 175

 gcc ggc gtc cag gct ttg ttg cag gta ttt ttg acg aac tct gca aac      576
 Ala Gly Val Gln Ala Leu Leu Gln Val Phe Leu Thr Asn Ser Ala Asn
             180                 185                 190

 atc ttt ttg ttg gaa cca tgt gct gaa gtt cct gtg ctc ttg aaa gaa      624
 Ile Phe Leu Leu Glu Pro Cys Ala Glu Val Pro Val Leu Leu Lys Glu
         195                 200                 205

 caa gtt gat gct tgt aaa gct gtt ttg att att ttt agg cgc atg ata      672
 Gln Val Asp Ala Cys Lys Ala Val Leu Ile Ile Phe Arg Arg Met Ile
     210                 215                 220

 atg gag ctt aca atg aat aaa aag aca tgg gaa cag atg ttg caa ata      720
 Met Glu Leu Thr Met Asn Lys Lys Thr Trp Glu Gln Met Leu Gln Ile
 225                 230                 235                 240

 cta ctc agg ata aca gaa gct gtc atg cag aag cca aag gat aaa cga      768
 Leu Leu Arg Ile Thr Glu Ala Val Met Gln Lys Pro Lys Asp Lys Arg
                 245                 250                 255

 ata aag gac ttg ttt gcc cag agc ttg gca ggg tta cta ttt agg acg      816
 Ile Lys Asp Leu Phe Ala Gln Ser Leu Ala Gly Leu Leu Phe Arg Thr
             260                 265                 270

 ctc atg gta gct tgg atc cga gca aac ctc tgt gtg tac att tct cga      864
 Leu Met Val Ala Trp Ile Arg Ala Asn Leu Cys Val Tyr Ile Ser Arg
         275                 280                 285

 gag ctc tgg gat gac ttt ctt ggt gtg ctg tcc ttc ctc acg gaa tgg      912
 Glu Leu Trp Asp Asp Phe Leu Gly Val Leu Ser Phe Leu Thr Glu Trp
     290                 295                 300

 gag gaa ctt ata aac gag tgg gcc aac att atg gac tcc ttg aca gca      960
 Glu Glu Leu Ile Asn Glu Trp Ala Asn Ile Met Asp Ser Leu Thr Ala
 305                 310                 315                 320

 gtg ctt gca aga acc gtt tat gga gtt gag atg aca aac cta cct ctg     1008
 Val Leu Ala Arg Thr Val Tyr Gly Val Glu Met Thr Asn Leu Pro Leu
                 325                 330                 335

 gat aaa tta agt gaa caa aag gaa aag aag caa cga ggc aaa ggc tgc     1056
 Asp Lys Leu Ser Glu Gln Lys Glu Lys Lys Gln Arg Gly Lys Gly Cys
             340                 345                 350

 gtt cta gat cct cag aaa gga acc acc gtg ggg agg tcc tct tct ctc     1104
 Val Leu Asp Pro Gln Lys Gly Thr Thr Val Gly Arg Ser Ser Ser Leu
         355                 360                 365

 agc tgg cgg agc cac cca gat gtg acc gaa ccg atg cga ttt agg agt     1152
 Ser Trp Arg Ser His Pro Asp Val Thr Glu Pro Met Arg Phe Arg Ser
     370                 375                 380

 gcc acc acg tct gga gca ccg gga gtg gaa aag gca aga aat att gtt     1200
 Ala Thr Thr Ser Gly Ala Pro Gly Val Glu Lys Ala Arg Asn Ile Val
 385                 390                 395                 400

 cgc caa aaa gca act gaa gtg gag gag tgt caa cag tca gaa aat gca     1248
 Arg Gln Lys Ala Thr Glu Val Glu Glu Cys Gln Gln Ser Glu Asn Ala
                 405                 410                 415

 cct gca gcc gga tct ggc cat ctc aca gtg gga cag cag cag cag gtc     1296
 Pro Ala Ala Gly Ser Gly His Leu Thr Val Gly Gln Gln Gln Gln Val
             420                 425                 430

 ctt cgg agc agc agc acc tcc gac atc ccc gag ccg ctg tgc tca gat     1344
 Leu Arg Ser Ser Ser Thr Ser Asp Ile Pro Glu Pro Leu Cys Ser Asp
         435                 440                 445

 tct tct cag ggt caa aag gca gaa aac aca cag aat tcg agt tct tca     1392
 Ser Ser Gln Gly Gln Lys Ala Glu Asn Thr Gln Asn Ser Ser Ser Ser
     450                 455                 460

 gag cct cag cct att caa gag aat aaa gga cat gtg aag aga gaa cat     1440
 Glu Pro Gln Pro Ile Gln Glu Asn Lys Gly His Val Lys Arg Glu His
 465                 470                 475                 480

 gaa gga ata aca atc tta gtt cga aga agc agc agc cct gct gaa ttg     1488
 Glu Gly Ile Thr Ile Leu Val Arg Arg Ser Ser Ser Pro Ala Glu Leu
                 485                 490                 495

 gat ttg aaa gat gat ttg cag cag aca caa gga aaa tgt agg gaa aga     1536
 Asp Leu Lys Asp Asp Leu Gln Gln Thr Gln Gly Lys Cys Arg Glu Arg
             500                 505                 510

 cag aag agt gaa agt acc aac agt gac aca act ctg ggc tgt acc aat     1584
 Gln Lys Ser Glu Ser Thr Asn Ser Asp Thr Thr Leu Gly Cys Thr Asn
         515                 520                 525

 gag gca gag ctg tcc atg ggc cca tgg cag acc tgt gag gaa gac cca     1632
 Glu Ala Glu Leu Ser Met Gly Pro Trp Gln Thr Cys Glu Glu Asp Pro
     530                 535                 540

 gaa ctg aat act ccc aca gat gtt gtg gct gat gct gat gcc cgt cat     1680
 Glu Leu Asn Thr Pro Thr Asp Val Val Ala Asp Ala Asp Ala Arg His
 545                 550                 555                 560

 tgg tta caa ctg agt ccc acc gat gct tca aat tta aca gat agc agc     1728
 Trp Leu Gln Leu Ser Pro Thr Asp Ala Ser Asn Leu Thr Asp Ser Ser
                 565                 570                 575

 gag tgc ctc aca gat gac tgt agt ata atc gcc ggg ggg agc ctc act     1776
 Glu Cys Leu Thr Asp Asp Cys Ser Ile Ile Ala Gly Gly Ser Leu Thr
             580                 585                 590

 ggt tgg cac cca gac tct gct gct gtg tta tgg cga agg gtc ttg ggg     1824
 Gly Trp His Pro Asp Ser Ala Ala Val Leu Trp Arg Arg Val Leu Gly
         595                 600                 605

 atc ctc gga gat gtg aat aac atc cag tca ccc aag atc cat gcc aga     1872
 Ile Leu Gly Asp Val Asn Asn Ile Gln Ser Pro Lys Ile His Ala Arg
     610                 615                 620

 gtt ttc tgc tat ctc tat gaa ctc tgg tac aaa cta gca aag ata cgg     1920
 Val Phe Cys Tyr Leu Tyr Glu Leu Trp Tyr Lys Leu Ala Lys Ile Arg
 625                 630                 635                 640

 gat aat cta gca ata agc ctg gat aac cag tct tct cca tct cct cca     1968
 Asp Asn Leu Ala Ile Ser Leu Asp Asn Gln Ser Ser Pro Ser Pro Pro
                 645                 650                 655

 gtt ttg atc cca cca ctc aga atg ttt gca tca tgg ctg ttt aag gcg     2016
 Val Leu Ile Pro Pro Leu Arg Met Phe Ala Ser Trp Leu Phe Lys Ala
             660                 665                 670

 gcg aca ctg cca aat gaa tat aag gaa ggc aaa cta caa gcc tac agg     2064
 Ala Thr Leu Pro Asn Glu Tyr Lys Glu Gly Lys Leu Gln Ala Tyr Arg
         675                 680                 685

 ctg atc tgt gcc atg atg acc aga cgc cag gac gtt ctg cca aac tca     2112
 Leu Ile Cys Ala Met Met Thr Arg Arg Gln Asp Val Leu Pro Asn Ser
     690                 695                 700

 gat ttc ctg gtg cat ttt tac ctt gtg atg cac ctg gga tta acc agc     2160
 Asp Phe Leu Val His Phe Tyr Leu Val Met His Leu Gly Leu Thr Ser
 705                 710                 715                 720

 gag gat cag gat atc tta aat acg atc ata agg cac tgt cca ccc cgc     2208
 Glu Asp Gln Asp Ile Leu Asn Thr Ile Ile Arg His Cys Pro Pro Arg
                 725                 730                 735

 ttt ttc tcc ctg ggt ttt cct ggc ttc tca atg ctg gtg ggg gac ttc     2256
 Phe Phe Ser Leu Gly Phe Pro Gly Phe Ser Met Leu Val Gly Asp Phe
             740                 745                 750

 atc acg gcc gct gcc agg gtc ctt agc aca gac att ttg acg gcg cct     2304
 Ile Thr Ala Ala Ala Arg Val Leu Ser Thr Asp Ile Leu Thr Ala Pro
         755                 760                 765

 cgt tca gag gct gtc act gtc ctc ggc tct ctg gtc tgc ttt cca aat     2352
 Arg Ser Glu Ala Val Thr Val Leu Gly Ser Leu Val Cys Phe Pro Asn
     770                 775                 780

 acc tac cag gag att cct tta ctg cag tca gtg cca gaa gta aat gag     2400
 Thr Tyr Gln Glu Ile Pro Leu Leu Gln Ser Val Pro Glu Val Asn Glu
 785                 790                 795                 800

 gcc att aca gga act gaa gat gtc aag cat tac ctc ata aat att tta     2448
 Ala Ile Thr Gly Thr Glu Asp Val Lys His Tyr Leu Ile Asn Ile Leu
                 805                 810                 815

 ctg aag aat gcc aca gaa gaa cca aat gaa tat gca aga tgc att gct     2496
 Leu Lys Asn Ala Thr Glu Glu Pro Asn Glu Tyr Ala Arg Cys Ile Ala
             820                 825                 830

 gtt tgc tcc ctt ggg gtc tgg ata tgt gaa gag ctt gca cag tgt aca     2544
 Val Cys Ser Leu Gly Val Trp Ile Cys Glu Glu Leu Ala Gln Cys Thr
         835                 840                 845

 agc cac cct cag gtg aaa gag gcc atc aat gtg ata gga gta act ctg     2592
 Ser His Pro Gln Val Lys Glu Ala Ile Asn Val Ile Gly Val Thr Leu
     850                 855                 860

 aag ttt ccc aac aaa atc gtg gcc cag gta gct tgc gat gtc ctt cag     2640
 Lys Phe Pro Asn Lys Ile Val Ala Gln Val Ala Cys Asp Val Leu Gln
 865                 870                 875                 880

 ttg ctg gtt tcc tac tgg gag aag ctt cag atg ttt gaa acc tct ctg     2688
 Leu Leu Val Ser Tyr Trp Glu Lys Leu Gln Met Phe Glu Thr Ser Leu
                 885                 890                 895

 cct cgg aaa atg gca gaa atc ctc gtg gcc aca gtt gct ttt ctt tta     2736
 Pro Arg Lys Met Ala Glu Ile Leu Val Ala Thr Val Ala Phe Leu Leu
             900                 905                 910

 cca agt gca gag tac tcc tca gtg gaa aca gac aag aag ttt att gtg     2784
 Pro Ser Ala Glu Tyr Ser Ser Val Glu Thr Asp Lys Lys Phe Ile Val
         915                 920                 925

 tcc ttg cta ctc tgc ctc ttg gac tgg tgc atg gca ttg ccc gtg agt     2832
 Ser Leu Leu Leu Cys Leu Leu Asp Trp Cys Met Ala Leu Pro Val Ser
     930                 935                 940

 gtc ctt ctc cac ccc gtg tcc aca gca gtc cta gag gag cag cat tcg     2880
 Val Leu Leu His Pro Val Ser Thr Ala Val Leu Glu Glu Gln His Ser
 945                 950                 955                 960

 gcc aga gcc ccc ttg ctg gat tat atc tac agg gtt ttg cac tgc tgt     2928
 Ala Arg Ala Pro Leu Leu Asp Tyr Ile Tyr Arg Val Leu His Cys Cys
                 965                 970                 975

 gtg tgt ggc tca agc acg tac acc caa cag agt cac tac ata ctg acc     2976
 Val Cys Gly Ser Ser Thr Tyr Thr Gln Gln Ser His Tyr Ile Leu Thr
             980                 985                 990

 ctg gct gac ttg tca tcc acg gat tat gac ccc ttc ctg cca ctg gca     3024
 Leu Ala Asp Leu Ser Ser Thr Asp Tyr Asp Pro Phe Leu Pro Leu Ala
         995                1000                1005

 aat gtg aag agc tct gag cca gtc cag tat cat tca tca gca gaa ttg     3072
 Asn Val Lys Ser Ser Glu Pro Val Gln Tyr His Ser Ser Ala Glu Leu
    1010                1015                1020

 ggt aac ctg ctg act gtt gaa gag gag aag aag aga aga agt ttg gag     3120
 Gly Asn Leu Leu Thr Val Glu Glu Glu Lys Lys Arg Arg Ser Leu Glu
1025                1030                1035                1040

 ttg atc cct ttg act gct cga atg gtg atg gcc cac ctg gtg aac cac     3168
 Leu Ile Pro Leu Thr Ala Arg Met Val Met Ala His Leu Val Asn His
                1045                1050                1055

 ctg ggg cac tac ccc ctc agt ggg ggc cct gcc ata ctg cac agc ctt     3216
 Leu Gly His Tyr Pro Leu Ser Gly Gly Pro Ala Ile Leu His Ser Leu
            1060                1065                1070

 gtc agc gag aac cat gac aat gcc cat gtg gaa ggc tcc gag ctg tcc     3264
 Val Ser Glu Asn His Asp Asn Ala His Val Glu Gly Ser Glu Leu Ser
        1075                1080                1085

 ttt gag gtg ttc aga agt cca aac ctg cag ctg ttt gta ttt aat gat     3312
 Phe Glu Val Phe Arg Ser Pro Asn Leu Gln Leu Phe Val Phe Asn Asp
    1090                1095                1100

 agc acc ctc atc tcc tac ctt cag aca ccc aca gaa gga ccg gta ggg     3360
 Ser Thr Leu Ile Ser Tyr Leu Gln Thr Pro Thr Glu Gly Pro Val Gly
1105                1110                1115                1120

 gga tca cca gtg ggc tct ctc tct gat gtg aga gta att gtg agg gat     3408
 Gly Ser Pro Val Gly Ser Leu Ser Asp Val Arg Val Ile Val Arg Asp
                1125                1130                1135

 atc tca ggg aag tac tct tgg gat ggt aag gtt tta tat gga cct ttg     3456
 Ile Ser Gly Lys Tyr Ser Trp Asp Gly Lys Val Leu Tyr Gly Pro Leu
            1140                1145                1150

 gaa ggc tgc tta gca ccc aat gga aga aat cct tca ttt ctg att tcg     3504
 Glu Gly Cys Leu Ala Pro Asn Gly Arg Asn Pro Ser Phe Leu Ile Ser
        1155                1160                1165

 agc tgg cat cgt gac aca ttt gga cct cag aaa gac tct tct caa gtt     3552
 Ser Trp His Arg Asp Thr Phe Gly Pro Gln Lys Asp Ser Ser Gln Val
    1170                1175                1180

 gag gag ggg gat gat gtt ctt gac aaa tta ctt gaa aac att ggc cat     3600
 Glu Glu Gly Asp Asp Val Leu Asp Lys Leu Leu Glu Asn Ile Gly His
1185                1190                1195                1200

 aca agt cct gaa tgc ctt tta ccg tca cag cta aat cta aat gaa cct     3648
 Thr Ser Pro Glu Cys Leu Leu Pro Ser Gln Leu Asn Leu Asn Glu Pro
                1205                1210                1215

 tcc cta acc cca tgt ggc atg aac tat gac caa gag aag gaa atc att     3696
 Ser Leu Thr Pro Cys Gly Met Asn Tyr Asp Gln Glu Lys Glu Ile Ile
            1220                1225                1230

 gag gtc att ttg cgc caa aat gct caa gag gat gag tat atc cag agt     3744
 Glu Val Ile Leu Arg Gln Asn Ala Gln Glu Asp Glu Tyr Ile Gln Ser
        1235                1240                1245

 cat aac ttc gat tct gca atg aaa gtc acc agc caa ggg cag ccc tcc     3792
 His Asn Phe Asp Ser Ala Met Lys Val Thr Ser Gln Gly Gln Pro Ser
    1250                1255                1260

 cca gtg gag ccc cga gga ccc ttt tat ttc tgc agg tta ttg ctt gat     3840
 Pro Val Glu Pro Arg Gly Pro Phe Tyr Phe Cys Arg Leu Leu Leu Asp
1265                1270                1275                1280

 gac ttg gga atg aat tct tgg gac aga agg aag aat ttt cat cta ttg     3888
 Asp Leu Gly Met Asn Ser Trp Asp Arg Arg Lys Asn Phe His Leu Leu
                1285                1290                1295

 aag aaa aat tca aaa tta ttg aga gag ctg aaa aat ttg gac tcc cgc     3936
 Lys Lys Asn Ser Lys Leu Leu Arg Glu Leu Lys Asn Leu Asp Ser Arg
            1300                1305                1310

 cag tgc cgt gag aca cac aaa atc gca gtg ttt tac att gct gaa ggt     3984
 Gln Cys Arg Glu Thr His Lys Ile Ala Val Phe Tyr Ile Ala Glu Gly
        1315                1320                1325

 caa gaa gac aag tgt tca atc ctc tct aat gaa aga gga agc caa gca     4032
 Gln Glu Asp Lys Cys Ser Ile Leu Ser Asn Glu Arg Gly Ser Gln Ala
    1330                1335                1340

 tat gaa gac ttt gtt gct gga ctt gga tgg gag gtg gat ctc tcc acc     4080
 Tyr Glu Asp Phe Val Ala Gly Leu Gly Trp Glu Val Asp Leu Ser Thr
1345                1350                1355                1360

 cac tgt ggg ttc atg ggt ggc ctt cag cgc aat ggc agc acc ggg cag     4128
 His Cys Gly Phe Met Gly Gly Leu Gln Arg Asn Gly Ser Thr Gly Gln
                1365                1370                1375

 acg gcc cct tac tat gct acc tca act gtg gaa gtg att ttc cat gtt     4176
 Thr Ala Pro Tyr Tyr Ala Thr Ser Thr Val Glu Val Ile Phe His Val
            1380                1385                1390

 tcc act cga atg ccg tca gac tca gat gat tcc ctc acc aaa aag ctt     4224
 Ser Thr Arg Met Pro Ser Asp Ser Asp Asp Ser Leu Thr Lys Lys Leu
        1395                1400                1405

 cgt cac ttg ggg aat gac gag gtc cat atc gtc tgg tct gaa cac tcc     4272
 Arg His Leu Gly Asn Asp Glu Val His Ile Val Trp Ser Glu His Ser
    1410                1415                1420

 aga gac tac cgc agg ggt att atc cca act gcc ttt gga gat gtt tca     4320
 Arg Asp Tyr Arg Arg Gly Ile Ile Pro Thr Ala Phe Gly Asp Val Ser
1425                1430                1435                1440

 atc att att tac cca atg aag aat cac atg ttc ttc atc gcg ata acg     4368
 Ile Ile Ile Tyr Pro Met Lys Asn His Met Phe Phe Ile Ala Ile Thr
                1445                1450                1455

 aag aaa cct gag gtt cca ttt ttt ggg cct ctg ttt gat gga gcc ata     4416
 Lys Lys Pro Glu Val Pro Phe Phe Gly Pro Leu Phe Asp Gly Ala Ile
            1460                1465                1470

 gtg agt ggg aag ctg ctg cca agc ctt gta tgt gcc acg tgc atc aac     4464
 Val Ser Gly Lys Leu Leu Pro Ser Leu Val Cys Ala Thr Cys Ile Asn
        1475                1480                1485

 gcc agc agg gct gtg aag tgc ctc atc cca ctc tac cag agc ttc tat     4512
 Ala Ser Arg Ala Val Lys Cys Leu Ile Pro Leu Tyr Gln Ser Phe Tyr
    1490                1495                1500

 gaa gag cga gct ctg tat ctc gaa gca ata att cag aac cac cgc gaa     4560
 Glu Glu Arg Ala Leu Tyr Leu Glu Ala Ile Ile Gln Asn His Arg Glu
1505                1510                1515                1520

 gta atg aca ttc gag gat ttc gca gcc caa gtc ttt tct ccc tct ccc     4608
 Val Met Thr Phe Glu Asp Phe Ala Ala Gln Val Phe Ser Pro Ser Pro
                1525                1530                1535

 agc tac tcc ctc agc gga acg ggg gcc ctg gcc tcc agt ctg agt gct     4656
 Ser Tyr Ser Leu Ser Gly Thr Gly Ala Leu Ala Ser Ser Leu Ser Ala
            1540                1545                1550

 gac ctc gaa gag ccc ctg agt gag gag gag aca gaa cac cct ctc ctg     4704
 Asp Leu Glu Glu Pro Leu Ser Glu Glu Glu Thr Glu His Pro Leu Leu
        1555                1560                1565

 cct ctg ccc cga gcc act aaa ccc aga atc tcc agg aaa ttt cgt tgc     4752
 Pro Leu Pro Arg Ala Thr Lys Pro Arg Ile Ser Arg Lys Phe Arg Cys
    1570                1575                1580

 tgt act agt gcc ctc agc agg tct tcc cat tag tggacttc tgaagcccat     4803
 Cys Thr Ser Ala Leu Ser Arg Ser Ser His 
1585                1590

 ggtgaatccc actaccgtgt catcagatgg gactcaaact aggctgtatc atcttgtcct   4863

 gaaacctcac aaaccttgga cttccaaaga agaaaagaaa aagtcaccaa aaaccagaga   4923

 tgaacccact gacacgtggg cactggtgtg gctgctctgg gcagatgact gcaggaaaag   4983

 attctgcgct ttcagggagg gggcagaggg cagcttgctt ctgcacccca agttgtttct   5043

 tctcatttat gaacccaagc atgattcaca aaggggctgg caaaacaatt gtctaattga   5103

 ggaatctgat ctgcattgat tttgctagtt ccttttatgt taggatttat ggtttactca   5163

 aaaatttcat catcatggaa attggctttc cccggggtct tttgcccagg agaagtttta   5223

 cctcagttgt ccagtgtttt cccacatggt acctgacgcc cgctaactaa gcagaggctc   5283

 tcctcaccac gcagaggcgc ttcaggtcat gacagtgatg cccctatctt agaacactca   5343

 gaagattcca gaaatacagg gtcctgtcct tgcataagtt cctgcaggac aggaagtgtc   5403

 ccaaggctca aaacaacaca gaccacatcc acacaaaagg cgcatgccgg cttcaggcgc   5463

 taggctgaga cgggtacccc ccgaatggcc ttgtgcctcc aaaagcctca cgctgcaact   5523

 ttgctgctcc tgtctgttgc ccagagaggc ctcacacagg cctcagaaat gtttcttgtc   5583

 acacaaagct tttggtagcc gattccaagc gagggattta atccttacat ttttgcccat   5643

 ttggctccaa ggaaggctta ttagacctgt                                    5673




      <210> 224
      <211> 1710
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (432)..(1136)

      <400> 224
 atgacggcgg cgagaacccc ggctgggcgg gtctgggccg cgcgtcccgg ccgggctgcg     60

 gctgtcgtag cggggccagc gctgcagaag gcggcggctg gctctccggg acggtcacat    120

 cccgctgcag gggcgggcgg aggccgccgc actgcctccc gcaccgggga cccaggccag    180

 cgtccgggca acgccccctg ctcccggaca gactccgtgg cccgctcgag ccctgggggc    240

 tccgcagacc cgcgcccgct ccgcccgcag ctcggccccg cgctgcccgc gtcgccgggc    300

 gccgcgccgg gatggggtag gggcagcgcc accgagtcgg gcgatgggcc gccctctggg    360

 caccgagcag ccccccgagg cctgaccaac cgcgaggacc ggcggaggag ccccgcctgg    420

 atgtcaagcg g atg cca agc gga tgc cac agt tcc ccc ccc agc gga ctc     470
              Met Pro Ser Gly Cys His Ser Ser Pro Pro Ser Gly Leu
                1               5                  10

 cgt ggg gac atg gct tcg ctg gtg ccc ctt tcc cca tat cta agc ccc      518
 Arg Gly Asp Met Ala Ser Leu Val Pro Leu Ser Pro Tyr Leu Ser Pro
      15                  20                  25

 acg gtc ctc ctg ctg gtc agc tgt gac ctg ggc ttc gtg cga gca gac      566
 Thr Val Leu Leu Leu Val Ser Cys Asp Leu Gly Phe Val Arg Ala Asp
  30                  35                  40                  45

 cgg cct ccc tct cct gtg aat gtg acg gtc act cac ctc aga gcc aac      614
 Arg Pro Pro Ser Pro Val Asn Val Thr Val Thr His Leu Arg Ala Asn
                  50                  55                  60

 tcg gcc act gtg tcc tgg gac gtc cca gaa ggc aac atc gtc att ggc      662
 Ser Ala Thr Val Ser Trp Asp Val Pro Glu Gly Asn Ile Val Ile Gly
              65                  70                  75

 tac tcc att tcc cag caa cgg cag aat ggc ccc ggg cag cgt gtg att      710
 Tyr Ser Ile Ser Gln Gln Arg Gln Asn Gly Pro Gly Gln Arg Val Ile
          80                  85                  90

 cgg gag gtg aac acc acc acc cgg gcc tgt gcc ctc tgg ggc ctg gct      758
 Arg Glu Val Asn Thr Thr Thr Arg Ala Cys Ala Leu Trp Gly Leu Ala
      95                 100                 105

 gaa gac agt gac tac aca gtg cag gtc agg agc atc ggc ctt cgg gga      806
 Glu Asp Ser Asp Tyr Thr Val Gln Val Arg Ser Ile Gly Leu Arg Gly
 110                 115                 120                 125

 gag agt ccc cca ggg ccc cgg gtg cac ttc cga act ctc aag ggt tct      854
 Glu Ser Pro Pro Gly Pro Arg Val His Phe Arg Thr Leu Lys Gly Ser
                 130                 135                 140

 gac cgg cta cct tca aac agt tca agc cca ggt gac atc aca gtg gaa      902
 Asp Arg Leu Pro Ser Asn Ser Ser Ser Pro Gly Asp Ile Thr Val Glu
             145                 150                 155

 ggt ctg gat gga gag cgg cca ctg cag act ggg gaa gtg gtc atc att      950
 Gly Leu Asp Gly Glu Arg Pro Leu Gln Thr Gly Glu Val Val Ile Ile
         160                 165                 170

 gtg gtg gtg ttg ctc atg tgg gct gct gta att ggg ctg ttc tgc cgt      998
 Val Val Val Leu Leu Met Trp Ala Ala Val Ile Gly Leu Phe Cys Arg
     175                 180                 185

 cag tat gac atc atc aag gac aat gac tcc aac aac aat ccc aag gag     1046
 Gln Tyr Asp Ile Ile Lys Asp Asn Asp Ser Asn Asn Asn Pro Lys Glu
 190                 195                 200                 205

 aag gga aag ggg ccg gaa cag agt cct cag gga agg cca gtg ggg aca     1094
 Lys Gly Lys Gly Pro Glu Gln Ser Pro Gln Gly Arg Pro Val Gly Thr
                 210                 215                 220

 aga cag aaa aag tca cca tct atc aac acc atc gac gtt tga gtgaaga     1143
 Arg Gln Lys Lys Ser Pro Ser Ile Asn Thr Ile Asp Val 
             225                 230

 aacacaccca gaagagagat gcactaacaa ctggggatag ggatggggtc agggggagcc   1203

 caagatggtg atctgcccga gactcccaga gggtaatgcc actcccacaa tctcaggcct   1263

 ggtacccatc ctctttccac tgtgagcaga gccagaaggt aggtctgttc agagtctgtg   1323

 cccctggacc tggggagtgg atatcagatg ggatatctcc ttccattccc cggtccaggg   1383

 gagagtcact agttgtaccc tactccatta ggtcccaaat gggggcccca tttcacctgt   1443

 atcaggactc tgagcatccc cagctgcccc acatcttgcc tctggccctc agagaggggt   1503

 gtttctgtgg gtactcctct taccccagca aataaaagga attgtctgac cctagaggca   1563

 gatgctgcac tgcactactc caatgtcttc catggagcct caggtgctcc ccctctcacc   1623

 tggcagcccc ttcagctgct agtgatatca cttgttggac atttttccaa taaaggttct   1683

 tggacaaact ggaaaaaaaa aaaaaaa                                       1710




      <210> 225
      <211> 1733
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1733)

      <400> 225
 ggttaaacta tgtgagaggg aaaattacag tgcataaggg ggggaagaaa gtgtttgagc     60

 tgtatgttga acaagac   atg gat ttg gaa ggg ata gag agg aga agt ttt     110
                      Met Asp Leu Glu Gly Ile Glu Arg Arg Ser Phe
                        1               5                  10

 tcc cat gag gag gtc aag aga gtg agg gcc atg cct tgt gtt cag gcg      158
 Ser His Glu Glu Val Lys Arg Val Arg Ala Met Pro Cys Val Gln Ala
              15                  20                  25

 cag tat ggg tcc tcg cct caa gga gcc agc ccc gct tct cag agc tac      206
 Gln Tyr Gly Ser Ser Pro Gln Gly Ala Ser Pro Ala Ser Gln Ser Tyr
          30                  35                  40

 agt tac cac tct tcg gga gaa tac agc tcc gat ttc tta act cca gag      254
 Ser Tyr His Ser Ser Gly Glu Tyr Ser Ser Asp Phe Leu Thr Pro Glu
      45                  50                  55

 ttt gtc aag ttt agc atg gac ctc acc aac act gaa atc act gcc acc      302
 Phe Val Lys Phe Ser Met Asp Leu Thr Asn Thr Glu Ile Thr Ala Thr
  60                  65                  70                  75

 act tct ctc ccc agc ttc agt acc ttt atg gac aac tac agc aca ggc      350
 Thr Ser Leu Pro Ser Phe Ser Thr Phe Met Asp Asn Tyr Ser Thr Gly
                  80                  85                  90

 tac gac gtc aag cca cct tgc ttg tac caa atg ccc ctg tcc gga cag      398
 Tyr Asp Val Lys Pro Pro Cys Leu Tyr Gln Met Pro Leu Ser Gly Gln
              95                 100                 105

 cag tcc tcc att aag gta gaa gac att cag atg cac aac tac cag caa      446
 Gln Ser Ser Ile Lys Val Glu Asp Ile Gln Met His Asn Tyr Gln Gln
         110                 115                 120

 cac agc cac ctg ccc ccc cag tct gag gag atg atg ccg cac tcc ggg      494
 His Ser His Leu Pro Pro Gln Ser Glu Glu Met Met Pro His Ser Gly
     125                 130                 135

 tcg gtt tac tac aag ccc tcc tcg ccc ccg acg ccc acc acc ccg ggc      542
 Ser Val Tyr Tyr Lys Pro Ser Ser Pro Pro Thr Pro Thr Thr Pro Gly
 140                 145                 150                 155

 ttc cag gtg cag cac agc ccc atg tgg gac gac ccg gga tct ctc cac      590
 Phe Gln Val Gln His Ser Pro Met Trp Asp Asp Pro Gly Ser Leu His
                 160                 165                 170

 aac ttc cac cag aac tac gtg gcc act acg cac atg atc gag cag agg      638
 Asn Phe His Gln Asn Tyr Val Ala Thr Thr His Met Ile Glu Gln Arg
             175                 180                 185

 aaa acg cca gtc tcc cgc ctc tcc ctc ttc tcc ttt aag caa tcg ccc      686
 Lys Thr Pro Val Ser Arg Leu Ser Leu Phe Ser Phe Lys Gln Ser Pro
         190                 195                 200

 cct ggc acc ccg gtg tct agt tgc cag atg cgc ttc gac ggg ccc ctg      734
 Pro Gly Thr Pro Val Ser Ser Cys Gln Met Arg Phe Asp Gly Pro Leu
     205                 210                 215

 cac gtc ccc atg aac ccg gag ccc gcc ggc agc cac cac gtg gtg gac      782
 His Val Pro Met Asn Pro Glu Pro Ala Gly Ser His His Val Val Asp
 220                 225                 230                 235

 ggg cag acc ttc gct gtg ccc aac ccc att cgc aag ccc gcg tcc atg      830
 Gly Gln Thr Phe Ala Val Pro Asn Pro Ile Arg Lys Pro Ala Ser Met
                 240                 245                 250

 ggc ttc ccg ggc ctg cag atc ggc cac gcg tct cag ctg ctc gac acg      878
 Gly Phe Pro Gly Leu Gln Ile Gly His Ala Ser Gln Leu Leu Asp Thr
             255                 260                 265

 cag cgc aca gtg caa aaa aat gca aaa tac gtg tgt tta gca aat aaa      926
 Gln Arg Thr Val Gln Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys
         270                 275                 280

 aac tgc cca gtg gac aag cgt cgc cgg aat cgc tgt cag tac tgc cga      974
 Asn Cys Pro Val Asp Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg
     285                 290                 295

 ttt cag aag tgc ctg gct gtt ggg atg gtc aaa gaa gtg gtt cgc aca     1022
 Phe Gln Lys Cys Leu Ala Val Gly Met Val Lys Glu Val Val Arg Thr
 300                 305                 310                 315

 gac agt tta aaa ggc cgg aga ggt cgt ttg ccc tcg aaa ccg aag agc     1070
 Asp Ser Leu Lys Gly Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser
                 320                 325                 330

 cca cag gag ccc tct ccc cct tcg ccc ccg gcg aac cct gac tat caa     1118
 Pro Gln Glu Pro Ser Pro Pro Ser Pro Pro Ala Asn Pro Asp Tyr Gln
             335                 340                 345

 atg agt gga gat gac acc cag cat atc cag caa ttc tat gat ctc ctg     1166
 Met Ser Gly Asp Asp Thr Gln His Ile Gln Gln Phe Tyr Asp Leu Leu
         350                 355                 360

 act ggc tcc atg gag atc atc cgg ggc tgg gca gag aag atc cct ggc     1214
 Thr Gly Ser Met Glu Ile Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly
     365                 370                 375

 ttc gca gac ctg ccc aaa gcc gac caa gac ctg ctt ttt gaa tca gct     1262
 Phe Ala Asp Leu Pro Lys Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala
 380                 385                 390                 395

 ttc tta gaa ctg ttt gtc ctt cga tta gca tac agg tcc aac cca gtg     1310
 Phe Leu Glu Leu Phe Val Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val
                 400                 405                 410

 gag ggt aaa ctc atc ttt tgc aat ggg gtg gtc ttg cac agg ttg caa     1358
 Glu Gly Lys Leu Ile Phe Cys Asn Gly Val Val Leu His Arg Leu Gln
             415                 420                 425

 tgc gtt cgt ggc ttt ggg gaa tgg att gat tcc att gtt gaa ttc tcc     1406
 Cys Val Arg Gly Phe Gly Glu Trp Ile Asp Ser Ile Val Glu Phe Ser
         430                 435                 440

 tcc aac ttg cag aat atg aac atc gac att tct gcc ttc tcc tgc att     1454
 Ser Asn Leu Gln Asn Met Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile
     445                 450                 455

 gct gcc ctg gct atg gtc aca gag aga cac ggg ctc aag gaa ccc aag     1502
 Ala Ala Leu Ala Met Val Thr Glu Arg His Gly Leu Lys Glu Pro Lys
 460                 465                 470                 475

 aga gtg gaa gaa ctg caa aac aag att gta aat tgt ctc aaa gac cac     1550
 Arg Val Glu Glu Leu Gln Asn Lys Ile Val Asn Cys Leu Lys Asp His
                 480                 485                 490

 gtg act ttc aac aat ggg ggg ttg aac cgc ccc aat tat ttg tcc aaa     1598
 Val Thr Phe Asn Asn Gly Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys
             495                 500                 505

 ctg ttg ggg aag ctc cca gaa ctt cgt acc ctt tgc aca cag ggg cta     1646
 Leu Leu Gly Lys Leu Pro Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu
         510                 515                 520

 cag cgc att ttc tac ctg aaa ttg gaa gac ttg gtg cca ccg cca gca     1694
 Gln Arg Ile Phe Tyr Leu Lys Leu Glu Asp Leu Val Pro Pro Pro Ala
     525                 530                 535

 ata att gac aaa ctt ttc ctg gac act tta cct ttc taa                 1733
 Ile Ile Asp Lys Leu Phe Leu Asp Thr Leu Pro Phe 
 540                 545                 550





      <210> 226
      <211> 1499
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (528)..(1499)

      <400> 226
 gcattctaag taaaagatgt tcatatatga ccttatggga atttcttatt cacaacatgg     60

 taactatcaa ttgaactctc tcccacataa gagagacaag aaaagaagtg gggaaaacag    120

 attttaaaag ctgtatgagc ttttacaata atttagcagg taacagagat cttgtgagac    180

 acagtaaaaa gccttgtatt cattgcttat caggtaaatg tggacttaaa gtaaataagg    240

 taagaaggtg ttgagctaga aacatgtctc aaattatttc cagtgagctt ctgaaagccc    300

 aagacaaatg tatctttatg aaaaattgag acagacccag taaccagatc ctctcattat    360

 ttgcatgtga agcctctaac ttgtagtcat gtgataaaca aatggagaaa aattggaaat    420

 aaccattaat gagggcggca gaaattataa cattgagcaa gggtcagaag attgcagagc    480

 agttacccat tcttggcgca gaaacctgaa agtcaggatc aaagaga  atg gca acg     536
                                                      Met Ala Thr
                                                        1

 gtg aac aca gat gcc aca gat aaa gac ata tcc aag ttc aag gtc acc      584
 Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe Lys Val Thr
       5                  10                  15

 tcc act ttg gtg gtc tcc gga ata gag tgc atc act ggc atc ctt ggg      632
 Ser Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly Ile Leu Gly
  20                  25                  30                  35

 agt ggc ttc atc acg gcc atc tat ggg gct gag tgg gcc agg ggc aaa      680
 Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala Arg Gly Lys
                  40                  45                  50

 aca ctc ccc act ggt gac cgc att atg ttg atg ctg agc ttt tcc agg      728
 Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser Phe Ser Arg
              55                  60                  65

 ctc ttg cta cag att tgg atg atg ctg gag aac att ttc agt ctg cta      776
 Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe Ser Leu Leu
          70                  75                  80

 ttc cga att gtt tat aac caa aac tca gtg tat atc ctc ttc aaa gtc      824
 Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu Phe Lys Val
      85                  90                  95

 atc act gtc ttt ctg aac cat tcc aat ctc tgg ttt gct gcc tgg ctc      872
 Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala Ala Trp Leu
 100                 105                 110                 115

 aaa gtc ttc tat tgt ctt aga att gca aac ttc aat cat cct ttg ttc      920
 Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His Pro Leu Phe
                 120                 125                 130

 ttc ctg atg aag agg aaa atc ata gtg ctg atc cct tgg ctt ctc agg      968
 Phe Leu Met Lys Arg Lys Ile Ile Val Leu Ile Pro Trp Leu Leu Arg
             135                 140                 145

 ctg cca gtg ttg gtc tcc tta agc ttc agc ttt cct ctc tcg aga gag     1016
 Leu Pro Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu Ser Arg Glu
         150                 155                 160

 gtc ttc aat gtg tat gtg aat agc tcc att cct atc ccc tcc tcc aac     1064
 Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro Ser Ser Asn
     165                 170                 175

 tcc acg gag aag aag tac ttc tct gag acc aat atg gtc aac ctg gta     1112
 Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val Asn Leu Val
 180                 185                 190                 195

 ttg ttc tat aac atg ggg atc ttc gtt cct ctg atc atg ttc atc ctg     1160
 Leu Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met Phe Ile Leu
                 200                 205                 210

 gca gcc acc ctg ctg atc ctc tct ctc aag aga cac acc cta cac atg     1208
 Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr Leu His Met
             215                 220                 225

 gga agc aat gcc aca ggg tcc agg gac ccc agc atg aag gct cac ata     1256
 Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys Ala His Ile
         230                 235                 240

 ggg gcc atc aaa gcc acc agc tac ttt ctc atc ctc tac att ttc aat     1304
 Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr Ile Phe Asn
     245                 250                 255

 gca att gct cta ttt ctt tcc acg tcc aac atc ttt gac act tac agt     1352
 Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp Thr Tyr Ser
 260                 265                 270                 275

 tcc tgg aat att ttg tgc aag atc atc atg gct gcc tac cct gcc ggc     1400
 Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr Pro Ala Gly
                 280                 285                 290

 cac tca gta caa ctg atc ttg ggc aac cct ggg ctg aga aga gcc tgg     1448
 His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg Arg Ala Trp
             295                 300                 305

 aag cgg ttt cag cac caa gtt cct ctt tac cta aaa ggg cag act ctg     1496
 Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly Gln Thr Leu
         310                 315                 320

 tga                                                                 1499
 






      <210> 227
      <211> 4489
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(3999)

      <400> 227
 gcgccgtccc ggccatgggc gcccgcggcg gcctgcggag ctggaggcgc ggcgccggcc     60

 gccaggcgcc tttgtgagcg gcgcggacga caaaggcgcg ggcccgggca gccgaggtgt    120

 gtagctggga cggtgctggt ctgagctgga ccttgtctg   atg gct tcc tcc aac     174
                                              Met Ala Ser Ser Asn
                                                1               5

 cct cct cca cag cct gcc ata gga gat cag ctg gtt cca gga gtc cca      222
 Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu Val Pro Gly Val Pro
                  10                  15                  20

 ggc ccc tcc tct gag gca gag gac gac cca gga gag gcg ttt gag ttt      270
 Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly Glu Ala Phe Glu Phe
              25                  30                  35

 gat gac agt gat gat gaa gag gac acc agc gca gcc ctg ggc gtc ccc      318
 Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala Ala Leu Gly Val Pro
          40                  45                  50

 agc ctt gct cct gag agg gac aca gac ccc cca ctg atc cac ttg gac      366
 Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro Leu Ile His Leu Asp
      55                  60                  65

 tcc atc cct gtc act gac cca gac cca gca gct gct cca ccc ggc aca      414
 Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala Ala Pro Pro Gly Thr
  70                  75                  80                  85

 ggg gtg cca gcc tgg gtg agc aat ggg gat gca gcg gac gca gcc ttc      462
 Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala Ala Asp Ala Ala Phe
                  90                  95                 100

 tcc ggg gcc cgg cac tcc agc tgg aag cgg aag agt tcc cgt cgc att      510
 Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys Ser Ser Arg Arg Ile
             105                 110                 115

 gac cgg ttc act ttc ccc gcc ctg gaa gag gat gtg att tat gac gac      558
 Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp Val Ile Tyr Asp Asp
         120                 125                 130

 gtc ccc tgc gag agc cca gat gcg cat cag ccc ggg gca gag agg aac      606
 Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro Gly Ala Glu Arg Asn
     135                 140                 145

 ctg ctc tac gag gat gcg cac cgg gct ggg gcc cct cgg cag gcg gag      654
 Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala Pro Arg Gln Ala Glu
 150                 155                 160                 165

 gac cta ggc tgg agc tcc agt gag ttc gag agc tac agc gag gac tcg      702
 Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser Tyr Ser Glu Asp Ser
                 170                 175                 180

 ggg gag gag gcc aag ccg gag gtc gag gtc gag ccc gcc aag cac cga      750
 Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu Pro Ala Lys His Arg
             185                 190                 195

 gtg tcc ttc cag ccc aag ctt tct cca gac ctg act agg cta aag gag      798
 Val Ser Phe Gln Pro Lys Leu Ser Pro Asp Leu Thr Arg Leu Lys Glu
         200                 205                 210

 aga tac gcc agg act aag aga gac atc ttg gct ttg aga gtt ggg ggg      846
 Arg Tyr Ala Arg Thr Lys Arg Asp Ile Leu Ala Leu Arg Val Gly Gly
     215                 220                 225

 aga gac atg cag gag ctg aag cac aag tac gat tgt aag atg acc cag      894
 Arg Asp Met Gln Glu Leu Lys His Lys Tyr Asp Cys Lys Met Thr Gln
 230                 235                 240                 245

 ctc atg aag gcc gcc aag agc ggg acc aag gat ggg ctg gag aag aca      942
 Leu Met Lys Ala Ala Lys Ser Gly Thr Lys Asp Gly Leu Glu Lys Thr
                 250                 255                 260

 cgg atg gcc gtg atg cgc aaa gtc tcc ttc ctg cac agg aag gac gtc      990
 Arg Met Ala Val Met Arg Lys Val Ser Phe Leu His Arg Lys Asp Val
             265                 270                 275

 ctc ggt gac tcg gag gag gag gac atg ggg ctc ctg gag gtc agc gtt     1038
 Leu Gly Asp Ser Glu Glu Glu Asp Met Gly Leu Leu Glu Val Ser Val
         280                 285                 290

 tcg gac atc aag ccc cca gcc cca gag ctg ggc ccc atg cca gag ggc     1086
 Ser Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly Pro Met Pro Glu Gly
     295                 300                 305

 ctg agc cct cag cag gtg gtc cgg agg cat atc ctg ggc tcc atc gtg     1134
 Leu Ser Pro Gln Gln Val Val Arg Arg His Ile Leu Gly Ser Ile Val
 310                 315                 320                 325

 cag agc gaa ggc agc tac gtg gag tct ctg aag cgg ata ctc cag gac     1182
 Gln Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys Arg Ile Leu Gln Asp
                 330                 335                 340

 tac cgc aac ccc ctg atg gag atg gag ccc aag gcg ctg agc gcc cgc     1230
 Tyr Arg Asn Pro Leu Met Glu Met Glu Pro Lys Ala Leu Ser Ala Arg
             345                 350                 355

 aag tgc cag gtg gtg ttc ttc cgc gtg aag gag atc ctg cac tgc cac     1278
 Lys Cys Gln Val Val Phe Phe Arg Val Lys Glu Ile Leu His Cys His
         360                 365                 370

 tcc atg ttc cag atc gcc ctg tcc tcc cgc gtg gct gag tgg gat tcc     1326
 Ser Met Phe Gln Ile Ala Leu Ser Ser Arg Val Ala Glu Trp Asp Ser
     375                 380                 385

 acc gag aag atc ggg gac ctc ttc gtg gcc tcg ttt tcc aag tcc atg     1374
 Thr Glu Lys Ile Gly Asp Leu Phe Val Ala Ser Phe Ser Lys Ser Met
 390                 395                 400                 405

 gtg cta gat gtg tac agt gac tac gtg aac aac ttc acc agt gcc atg     1422
 Val Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn Phe Thr Ser Ala Met
                 410                 415                 420

 tcc atc atc aag aag gcc tgc ctc acc aag cct gcc ttc ctc gag ttc     1470
 Ser Ile Ile Lys Lys Ala Cys Leu Thr Lys Pro Ala Phe Leu Glu Phe
             425                 430                 435

 ctc aag cga cgg cag gtg tgc agc cca gac cgt gtc acc ctc tac ggg     1518
 Leu Lys Arg Arg Gln Val Cys Ser Pro Asp Arg Val Thr Leu Tyr Gly
         440                 445                 450

 ctg atg gtc aag ccc atc cag agg ttc cca cag ttc ata ctc ctg ctt     1566
 Leu Met Val Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu
     455                 460                 465

 cag gac atg ctg aag aac acc ccc agg ggc cat ccg gac agg ctg tcg     1614
 Gln Asp Met Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu Ser
 470                 475                 480                 485

 ctg cag ctg gcc ctc aca gag ctg gag acg ctg gct gag aag ctg aac     1662
 Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn
                 490                 495                 500

 gag cag aag cgg ctg gct gac cag gtg gct gag atc cag cag ctg acc     1710
 Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu Ile Gln Gln Leu Thr
             505                 510                 515

 aag agc gtc agt gac cgc agc agc ctc aac aag ctg ttg acc tca ggc     1758
 Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys Leu Leu Thr Ser Gly
         520                 525                 530

 cag cgg cag ctg ctc ctg tgt gag acg ttg acg gag acc gtg tac ggt     1806
 Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr Glu Thr Val Tyr Gly
     535                 540                 545

 gac cgc ggg cag cta att aag tcc aag gag cgt cgg gtc ttc ctg ctc     1854
 Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg Arg Val Phe Leu Leu
 550                 555                 560                 565

 aac gac atg ctt gtc tgt gcc aac atc aac ttc aag cct gcc aac cac     1902
 Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe Lys Pro Ala Asn His
                 570                 575                 580

 agg ggc cag ctg gag att agc agc ctg gtg ccc ctg ggg ccc aag tat     1950
 Arg Gly Gln Leu Glu Ile Ser Ser Leu Val Pro Leu Gly Pro Lys Tyr
             585                 590                 595

 gtg gtg aag tgg aac acg gcg ctg ccc cag gtg cag gtg gtg gag gtg     1998
 Val Val Lys Trp Asn Thr Ala Leu Pro Gln Val Gln Val Val Glu Val
         600                 605                 610

 ggc cag gac ggt ggc acc tat gac aag gac aat gtg ctc atc cag cac     2046
 Gly Gln Asp Gly Gly Thr Tyr Asp Lys Asp Asn Val Leu Ile Gln His
     615                 620                 625

 tca ggc gcc aag aag gcc tct gcc tca ggg cag gct cag aat aag gtg     2094
 Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln Ala Gln Asn Lys Val
 630                 635                 640                 645

 tac ctc ggc ccc cca cgc ctc ttc cag gag ctg cag gac ctg cag aag     2142
 Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu Gln Asp Leu Gln Lys
                 650                 655                 660

 gac ctg gcc gtg gtg gag cag atc acg ctt ctc atc agc acg ctg cac     2190
 Asp Leu Ala Val Val Glu Gln Ile Thr Leu Leu Ile Ser Thr Leu His
             665                 670                 675

 ggc acc tac cag aac ctg aac atg act gtg gct caa gac tgg tgc ctg     2238
 Gly Thr Tyr Gln Asn Leu Asn Met Thr Val Ala Gln Asp Trp Cys Leu
         680                 685                 690

 gcc ctg cag agg ctg atg cgg gtg aag gag gaa gag atc cac tcg gcc     2286
 Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu Glu Ile His Ser Ala
     695                 700                 705

 aac aag tgc cgt ctc agg ctc ctg ctt cct ggg aaa ccc gac aag tcc     2334
 Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly Lys Pro Asp Lys Ser
 710                 715                 720                 725

 ggc cgc ccc att agc ttc atg gtg gtt ttc atc acc ccc aac ccc ctg     2382
 Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile Thr Pro Asn Pro Leu
                 730                 735                 740

 agc aag att tcc tgg gtc aac agg tta cat ttg gcc aaa atc gga ctc     2430
 Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu Ala Lys Ile Gly Leu
             745                 750                 755

 cgg gag gag aac cag cca ggc tgg cta tgc ccg gat gag gac aag aag     2478
 Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro Asp Glu Asp Lys Lys
         760                 765                 770

 agc aaa gcc cca ttc tgg tgc ccg atc ctg gcc tgc tgc atc cct gcc     2526
 Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala Cys Cys Ile Pro Ala
     775                 780                 785

 ttc tcc tcc cgg gca ctc agc ctg cag ctt ggg gcc ctg gtc cac agt     2574
 Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly Ala Leu Val His Ser
 790                 795                 800                 805

 cct gtc aac tgt ccc ctg ctg ggt ttc tca gca gtc agc acc tcc ctt     2622
 Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala Val Ser Thr Ser Leu
                 810                 815                 820

 cca cag ggc tac ctc tgg gtc ggg ggc gga cag gaa ggc gca ggg ggc     2670
 Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln Glu Gly Ala Gly Gly
             825                 830                 835

 cag gtg gaa atc ttt tcc ttg aac cgg ccc tcg ccc cgc acc gtc aag     2718
 Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser Pro Arg Thr Val Lys
         840                 845                 850

 tcc ttc cca ctg gca gcc cct gtg ctc tgc atg gag tat atc ccg gag     2766
 Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met Glu Tyr Ile Pro Glu
     855                 860                 865

 ctg gag gag gag gcg gag agc aga gac gag agc ccg aca gtt gct gac     2814
 Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser Pro Thr Val Ala Asp
 870                 875                 880                 885

 ccc tcg gcc acg gtg cat cca acc atc tgc ctc ggg ctc cag gat ggc     2862
 Pro Ser Ala Thr Val His Pro Thr Ile Cys Leu Gly Leu Gln Asp Gly
                 890                 895                 900

 agc atc ctc ctc tac agc agt gtg gac act ggc acc cag tgc ctg gtg     2910
 Ser Ile Leu Leu Tyr Ser Ser Val Asp Thr Gly Thr Gln Cys Leu Val
             905                 910                 915

 agc tgc agg agc cca ggt ctg cag cct gtg ctc tgc ctg cga cac agc     2958
 Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu Cys Leu Arg His Ser
         920                 925                 930

 ccc ttc cac ctg ctc gct ggc ctg cag gat ggg acc ctt gct gct tac     3006
 Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly Thr Leu Ala Ala Tyr
     935                 940                 945

 cct cgg acc agc gga ggt gtc ctg tgg gac ctg gag agc cct ccc gtg     3054
 Pro Arg Thr Ser Gly Gly Val Leu Trp Asp Leu Glu Ser Pro Pro Val
 950                 955                 960                 965

 tgc ctg act gtg ggg ccc ggg cct gtc cgc acc ctg ttg agc ctg gag     3102
 Cys Leu Thr Val Gly Pro Gly Pro Val Arg Thr Leu Leu Ser Leu Glu
                 970                 975                 980

 gat gcc gtg tgg gcc agc tgt ggg ccc cgg gtc act gtc ctg gaa gcc     3150
 Asp Ala Val Trp Ala Ser Cys Gly Pro Arg Val Thr Val Leu Glu Ala
             985                 990                 995

 acc acc ctg cag cct cag caa agc ttc gag gcg cac cag gac gag gca     3198
 Thr Thr Leu Gln Pro Gln Gln Ser Phe Glu Ala His Gln Asp Glu Ala
        1000                1005                1010

 gtg agc gtg aca cac atg gtg aag gcg ggc agc ggc gtc tgg atg gcc     3246
 Val Ser Val Thr His Met Val Lys Ala Gly Ser Gly Val Trp Met Ala
    1015                1020                1025

 ttc tcc tcc ggc acc tcc atc cgc ctc ttc cac act gag acc ctg gag     3294
 Phe Ser Ser Gly Thr Ser Ile Arg Leu Phe His Thr Glu Thr Leu Glu
1030                1035                1040                1045

 cat ctg caa gag atc aac atc gcc acc agg acc acc ttc ctc ctg cca     3342
 His Leu Gln Glu Ile Asn Ile Ala Thr Arg Thr Thr Phe Leu Leu Pro
                1050                1055                1060

 ggc cag aag cac ttg tgt gtc acc agc ctc ctg atc tgc cag ggt ctg     3390
 Gly Gln Lys His Leu Cys Val Thr Ser Leu Leu Ile Cys Gln Gly Leu
            1065                1070                1075

 ctc tgg gtg ggc act gac cag ggt gtc atc gtc ctg ctg ccc gtg cct     3438
 Leu Trp Val Gly Thr Asp Gln Gly Val Ile Val Leu Leu Pro Val Pro
        1080                1085                1090

 cgg ctg gaa ggc atc ccc aag atc aca ggg aaa ggc atg gtc tca ctc     3486
 Arg Leu Glu Gly Ile Pro Lys Ile Thr Gly Lys Gly Met Val Ser Leu
    1095                1100                1105

 aat ggg cac tgt ggg cct gtg gcc ttc ctg gct gtg gct acc agc atc     3534
 Asn Gly His Cys Gly Pro Val Ala Phe Leu Ala Val Ala Thr Ser Ile
1110                1115                1120                1125

 ctg gcc cct gac atc ctg cgg agt gac cag gag gag gct gag ggg ccc     3582
 Leu Ala Pro Asp Ile Leu Arg Ser Asp Gln Glu Glu Ala Glu Gly Pro
                1130                1135                1140

 cgg gct gag gag gac aag cca gac ggg cag gca cac gag ccc atg ccc     3630
 Arg Ala Glu Glu Asp Lys Pro Asp Gly Gln Ala His Glu Pro Met Pro
            1145                1150                1155

 gac agc cac gtg ggc cga gag ctg acc cgc aag aag ggc atc ctc ttg     3678
 Asp Ser His Val Gly Arg Glu Leu Thr Arg Lys Lys Gly Ile Leu Leu
        1160                1165                1170

 cag tac cgc ctg cgc tcc acc gca cac ctc ccg ggc ccg ctg ctc tcc     3726
 Gln Tyr Arg Leu Arg Ser Thr Ala His Leu Pro Gly Pro Leu Leu Ser
    1175                1180                1185

 atg cgg gag ccg gcg cct gct gat ggc gca gct ttg gag cac agc gag     3774
 Met Arg Glu Pro Ala Pro Ala Asp Gly Ala Ala Leu Glu His Ser Glu
1190                1195                1200                1205

 gag gac ggc tcc att tac gag atg gcc gac gac ccc gac gtc tgg gtg     3822
 Glu Asp Gly Ser Ile Tyr Glu Met Ala Asp Asp Pro Asp Val Trp Val
                1210                1215                1220

 cgc agc cgg ccc tgc gcc cgc gac gcc cac cgc aag gag att tgc tct     3870
 Arg Ser Arg Pro Cys Ala Arg Asp Ala His Arg Lys Glu Ile Cys Ser
            1225                1230                1235

 gtg gcc atc atc tcc ggc ggg cag ggc tac cgc aac ttt ggc agc gct     3918
 Val Ala Ile Ile Ser Gly Gly Gln Gly Tyr Arg Asn Phe Gly Ser Ala
        1240                1245                1250

 ctg ggc agc agt ggg agg cag gcc ccg tgt ggg gag acg gac agc acc     3966
 Leu Gly Ser Ser Gly Arg Gln Ala Pro Cys Gly Glu Thr Asp Ser Thr
    1255                1260                1265

 ctc ctc atc tgg cag gtg ccc ttg atg cta tag cgcctccc ctctcccctc     4017
 Leu Leu Ile Trp Gln Val Pro Leu Met Leu 
1270                1275

 agagggcaca gctgcaggcc tgaccaaggc cacgcccggc tctcgtgctc taggacctgc   4077

 acgggacttg tggatgggcc tggactctcc agaaactact tgggccagag caaaggaaaa   4137

 cctcttgttt taaaaaaatt tttttcagag tgttttgggg aggagtttta gggcttgggg   4197

 agagggagga cacatctgga ggaaatggcc ttctttttaa aagcaaaaaa acacaaaacc   4257

 tcacaactgc ctggcaagcc cagtatcact tgtttgggcc ctagcgggac tccaaggcag   4317

 ccacacgccc ctcctggaag ggtgtgtgcg tgtgagtgtg tgcgagtgtg tgggctggtg   4377

 tgtgaatatc tataaataag tatatatggt gtatattata tgtgtataaa taaagtctgt   4437

 acatattgga gctctgggag atgctggaat aaaagacaag agttacatct gg           4489




      <210> 228
      <211> 2108
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(2108)

      <400> 228
 gttgggaccg a atg gat ata aat tgg ctt cac ttg tac gtc aaa aac tac      50
              Met Asp Ile Asn Trp Leu His Leu Tyr Val Lys Asn Tyr
                1               5                  10

 tgt aag cag ctt gca gca ggc ctg aga gaa gat cag agc ccc agc tgc       98
 Cys Lys Gln Leu Ala Ala Gly Leu Arg Glu Asp Gln Ser Pro Ser Cys
      15                  20                  25

 ccg agt gaa ata act ccc tca atc cag aac tat att gct tgc aca gcc      146
 Pro Ser Glu Ile Thr Pro Ser Ile Gln Asn Tyr Ile Ala Cys Thr Ala
  30                  35                  40                  45

 ttt ctc cgt gct cat agc agg gcc tgg tgt ggt cag tgc agg ggc cca      194
 Phe Leu Arg Ala His Ser Arg Ala Trp Cys Gly Gln Cys Arg Gly Pro
                  50                  55                  60

 cac acc tgt ggc cct gct gat gga gcc tgg tat atg ttg gcc caa ttc      242
 His Thr Cys Gly Pro Ala Asp Gly Ala Trp Tyr Met Leu Ala Gln Phe
              65                  70                  75

 act ggg ggt tgg aca tgc att gca act ata gct ttt cat gac tta cag      290
 Thr Gly Gly Trp Thr Cys Ile Ala Thr Ile Ala Phe His Asp Leu Gln
          80                  85                  90

 gga tcc aaa gag gtt ttc atg gct cct aaa gca tct cag gca gca gaa      338
 Gly Ser Lys Glu Val Phe Met Ala Pro Lys Ala Ser Gln Ala Ala Glu
      95                 100                 105

 agc agc gct ttt gga gaa aaa cat gat aat tgt aca acc aat agt tct      386
 Ser Ser Ala Phe Gly Glu Lys His Asp Asn Cys Thr Thr Asn Ser Ser
 110                 115                 120                 125

 aca agt gaa aat cgt gct tcg tgc tct ttt ttc ctt cca aga ata acg      434
 Thr Ser Glu Asn Arg Ala Ser Cys Ser Phe Phe Leu Pro Arg Ile Thr
                 130                 135                 140

 atc cca gat aat tat acc att gag gtg gaa gct gaa aat gga gat ggt      482
 Ile Pro Asp Asn Tyr Thr Ile Glu Val Glu Ala Glu Asn Gly Asp Gly
             145                 150                 155

 gta att aaa tct cat atg aca tac tgg aga tta gag aac ata gcg aaa      530
 Val Ile Lys Ser His Met Thr Tyr Trp Arg Leu Glu Asn Ile Ala Lys
         160                 165                 170

 act gaa cca cct aag att ttc cgt gtg aaa cca gtt ttg ggc atc aaa      578
 Thr Glu Pro Pro Lys Ile Phe Arg Val Lys Pro Val Leu Gly Ile Lys
     175                 180                 185

 cga atg att caa att gaa tgg ata aag cct gag ttg gcg cct gtt tca      626
 Arg Met Ile Gln Ile Glu Trp Ile Lys Pro Glu Leu Ala Pro Val Ser
 190                 195                 200                 205

 tct gat tta aaa tac aca ctt cga ttc agg aca gtc aac agt acc agc      674
 Ser Asp Leu Lys Tyr Thr Leu Arg Phe Arg Thr Val Asn Ser Thr Ser
                 210                 215                 220

 tgg atg gaa gtc aac ttc gct aag aac cgt aag gat aaa aac caa acg      722
 Trp Met Glu Val Asn Phe Ala Lys Asn Arg Lys Asp Lys Asn Gln Thr
             225                 230                 235

 tac aac ctc acg ggg ctg cag cct ttt aca gaa tat gtc ata gct ctg      770
 Tyr Asn Leu Thr Gly Leu Gln Pro Phe Thr Glu Tyr Val Ile Ala Leu
         240                 245                 250

 cga tgt gcg gtc aag gag tca aag ttc tgg agt gac tgg agc caa gaa      818
 Arg Cys Ala Val Lys Glu Ser Lys Phe Trp Ser Asp Trp Ser Gln Glu
     255                 260                 265

 aaa atg gga atg act gag gaa gaa gct cca tgt ggc ctg gaa ctg tgg      866
 Lys Met Gly Met Thr Glu Glu Glu Ala Pro Cys Gly Leu Glu Leu Trp
 270                 275                 280                 285

 aga gtc ctg aaa cca gct gag gcg gat gga aga agg cca gtg cgg ttg      914
 Arg Val Leu Lys Pro Ala Glu Ala Asp Gly Arg Arg Pro Val Arg Leu
                 290                 295                 300

 tta tgg aag aag gca aga gga gcc cca gtc cta gag aaa aca ctt ggc      962
 Leu Trp Lys Lys Ala Arg Gly Ala Pro Val Leu Glu Lys Thr Leu Gly
             305                 310                 315

 tac aac ata tgg tac tat cca gaa agc aac act aac ctc aca gaa aca     1010
 Tyr Asn Ile Trp Tyr Tyr Pro Glu Ser Asn Thr Asn Leu Thr Glu Thr
         320                 325                 330

 atg aac act act aac cag cag ctt gaa ctg cat ctg gga ggc gag agc     1058
 Met Asn Thr Thr Asn Gln Gln Leu Glu Leu His Leu Gly Gly Glu Ser
     335                 340                 345

 ttt tgg gtg tct atg att tct tat aat tct ctt ggg aag tct cca gtg     1106
 Phe Trp Val Ser Met Ile Ser Tyr Asn Ser Leu Gly Lys Ser Pro Val
 350                 355                 360                 365

 gcc acc ctg agg att cca gct att caa gaa aaa tca ttt cag tgc att     1154
 Ala Thr Leu Arg Ile Pro Ala Ile Gln Glu Lys Ser Phe Gln Cys Ile
                 370                 375                 380

 gag gtc atg cag gcc tgc gtt gct gag gac cag cta gtg gtg aag tgg     1202
 Glu Val Met Gln Ala Cys Val Ala Glu Asp Gln Leu Val Val Lys Trp
             385                 390                 395

 caa agc tct gct cta gac gtg aac act tgg atg att gaa tgg ttt ccg     1250
 Gln Ser Ser Ala Leu Asp Val Asn Thr Trp Met Ile Glu Trp Phe Pro
         400                 405                 410

 gat gtg gac tca gag ccc acc acc ctt tcc tgg gaa tct gtg tct cag     1298
 Asp Val Asp Ser Glu Pro Thr Thr Leu Ser Trp Glu Ser Val Ser Gln
     415                 420                 425

 gcc acg aac tgg acg atc cag caa gat aaa tta aaa cct ttc tgg tgc     1346
 Ala Thr Asn Trp Thr Ile Gln Gln Asp Lys Leu Lys Pro Phe Trp Cys
 430                 435                 440                 445

 tat aac atc tct gtg tat cca atg ttg cat gac aaa gtt ggc gag cca     1394
 Tyr Asn Ile Ser Val Tyr Pro Met Leu His Asp Lys Val Gly Glu Pro
                 450                 455                 460

 tat tcc atc cag gct tat gcc aaa gaa ggc gtt cca tca gaa ggt cct     1442
 Tyr Ser Ile Gln Ala Tyr Ala Lys Glu Gly Val Pro Ser Glu Gly Pro
             465                 470                 475

 gag acc aag gtg gag aac att ggc gtg aag acg gtc acg atc aca tgg     1490
 Glu Thr Lys Val Glu Asn Ile Gly Val Lys Thr Val Thr Ile Thr Trp
         480                 485                 490

 aaa gag att ccc aag agt gag aga aag ggt atc atc tgc aac tac act     1538
 Lys Glu Ile Pro Lys Ser Glu Arg Lys Gly Ile Ile Cys Asn Tyr Thr
     495                 500                 505

 atc ttt tac caa gct gaa ggt gga aaa gga ttc tcc aag aca gtc aat     1586
 Ile Phe Tyr Gln Ala Glu Gly Gly Lys Gly Phe Ser Lys Thr Val Asn
 510                 515                 520                 525

 tcc agc atc ttg cag tac ggc ctg gag tcc ctg aaa cga aag acc tct     1634
 Ser Ser Ile Leu Gln Tyr Gly Leu Glu Ser Leu Lys Arg Lys Thr Ser
                 530                 535                 540

 tac att gtt cag gtc atg gcc aac acc agt gct ggg gga acc aac ggg     1682
 Tyr Ile Val Gln Val Met Ala Asn Thr Ser Ala Gly Gly Thr Asn Gly
             545                 550                 555

 acc agc ata aat ttc aag aca ttg tca ttc agt gtc ttt gag att atc     1730
 Thr Ser Ile Asn Phe Lys Thr Leu Ser Phe Ser Val Phe Glu Ile Ile
         560                 565                 570

 ctc ata act tct ctg att ggt gga ggc ctt ctt att ctc att atc ctg     1778
 Leu Ile Thr Ser Leu Ile Gly Gly Gly Leu Leu Ile Leu Ile Ile Leu
     575                 580                 585

 aca gtg gca tat ggt ctc aaa aaa ccc aac aaa ttg act cat ctg tgt     1826
 Thr Val Ala Tyr Gly Leu Lys Lys Pro Asn Lys Leu Thr His Leu Cys
 590                 595                 600                 605

 tgg ccc acc gtt ccc aac cct gct gaa agt agt ata gcc aca tgg cat     1874
 Trp Pro Thr Val Pro Asn Pro Ala Glu Ser Ser Ile Ala Thr Trp His
                 610                 615                 620

 gga gat gat ttc aag gat aag cta aac ctg aag gag tct gat gac tct     1922
 Gly Asp Asp Phe Lys Asp Lys Leu Asn Leu Lys Glu Ser Asp Asp Ser
             625                 630                 635

 gtg aac aca gaa gac agg atc tta aaa cca tgt tcc acc ccc agt gac     1970
 Val Asn Thr Glu Asp Arg Ile Leu Lys Pro Cys Ser Thr Pro Ser Asp
         640                 645                 650

 aag ttg gtg att gac aag ttg gtg gtg aac ttt ggg aat gtt ctg caa     2018
 Lys Leu Val Ile Asp Lys Leu Val Val Asn Phe Gly Asn Val Leu Gln
     655                 660                 665

 gaa att ttc aca gat gaa gcc aga acg ggt cag gaa aac aat tta gga     2066
 Glu Ile Phe Thr Asp Glu Ala Arg Thr Gly Gln Glu Asn Asn Leu Gly
 670                 675                 680                 685

 ggg gaa aag aat gga tac caa gct ctc acc gag gcc tcc tga             2108
 Gly Glu Lys Asn Gly Tyr Gln Ala Leu Thr Glu Ala Ser 
                 690                 695





      <210> 229
      <211> 1065
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1065)

      <400> 229
  atg atg aaa cag tgt aga cag cct ttg gaa aaa acc cag tac ggc ttc      48
  Met Met Lys Gln Cys Arg Gln Pro Leu Glu Lys Thr Gln Tyr Gly Phe
    1               5                  10                  15

 cta gga aca gat cgt gta gaa gag aaa act tca gtg ata acc atc aga       96
 Leu Gly Thr Asp Arg Val Glu Glu Lys Thr Ser Val Ile Thr Ile Arg
              20                  25                  30

 gtt agt gtg acc cac aga cac aac agc tac atg gaa gca gaa aac ctt      144
 Val Ser Val Thr His Arg His Asn Ser Tyr Met Glu Ala Glu Asn Leu
          35                  40                  45

 aca gaa tta tca aaa ttt ctc ctc ctg gga ctc tca gat gat cct gaa      192
 Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly Leu Ser Asp Asp Pro Glu
      50                  55                  60

 ctg cag ccc gtc ctc ttt ggg ctg ttc ctg tcc atg tac ctg gtc acg      240
 Leu Gln Pro Val Leu Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr
  65                  70                  75                  80

 gtg ctg ggg aac ctg ctc atc att ctg gcc gtc agc tct gac tcc cac      288
 Val Leu Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His
                  85                  90                  95

 ctc cac acc ccc atg tac ttc ttc ctc tcc aac ctg tcc ttt gtt gac      336
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp
             100                 105                 110

 atc tgt ttc atc tcc acc aca gtc ccc aag atg cta gtg agc atc cag      384
 Ile Cys Phe Ile Ser Thr Thr Val Pro Lys Met Leu Val Ser Ile Gln
         115                 120                 125

 gca cgg agc aaa gac atc tcc tac atg ggg tgc ctc act cag gtg tat      432
 Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly Cys Leu Thr Gln Val Tyr
     130                 135                 140

 ttt tta atg atg ttt gct gga atg gat act ttc cta ctg gcc gtg atg      480
 Phe Leu Met Met Phe Ala Gly Met Asp Thr Phe Leu Leu Ala Val Met
 145                 150                 155                 160

 gcc tat gac cgg ttt gtg gcc atc tgc cac cca ctg cac tac acg gtc      528
 Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Thr Val
                 165                 170                 175

 atc atg aac ccc tgc ctc tgt ggc ctc ctg gtt ctg gca tct tgg ttc      576
 Ile Met Asn Pro Cys Leu Cys Gly Leu Leu Val Leu Ala Ser Trp Phe
             180                 185                 190

 atc att ttc tgg ttc tcc ctg gtt cat att cta ctg atg aag agg ttg      624
 Ile Ile Phe Trp Phe Ser Leu Val His Ile Leu Leu Met Lys Arg Leu
         195                 200                 205

 acc ttc tcc aca ggc act gag att ccg cat ttc ttc tgt gaa ccg gct      672
 Thr Phe Ser Thr Gly Thr Glu Ile Pro His Phe Phe Cys Glu Pro Ala
     210                 215                 220

 cag gtc ctc aag gtg gcc tgc tct aac acc ctc ctc aat aac att gtc      720
 Gln Val Leu Lys Val Ala Cys Ser Asn Thr Leu Leu Asn Asn Ile Val
 225                 230                 235                 240

 ttg tat gtg gcc acg gca ctg ctg ggt gtg ttt cct gta gct ggg atc      768
 Leu Tyr Val Ala Thr Ala Leu Leu Gly Val Phe Pro Val Ala Gly Ile
                 245                 250                 255

 ctc ttc tcc tac tct cag att gtc tcc tcc tta atg gga atg tcc tcc      816
 Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser Leu Met Gly Met Ser Ser
             260                 265                 270

 acc aag ggc aag tac aaa gcc ttt tcc acc tgt gga tct cac ctc tgt      864
 Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Cys
         275                 280                 285

 gtg gtc tcc ttg ttc tat gga aca gga ctt ggg gtc tat ctg agt tct      912
 Val Val Ser Leu Phe Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser
     290                 295                 300

 gct gtg acc cat tct tcc cag agc agc tcc acc gcc tca gtg atg tac      960
 Ala Val Thr His Ser Ser Gln Ser Ser Ser Thr Ala Ser Val Met Tyr
 305                 310                 315                 320

 gcc atg gtc acc ccc atg ctg aac ccc ttc atc tac agc ctg agg aac     1008
 Ala Met Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn
                 325                 330                 335

 aag gat gtg aag ggg gcc ctg gaa aga ctc ctc agc agg gcc gac tct     1056
 Lys Asp Val Lys Gly Ala Leu Glu Arg Leu Leu Ser Arg Ala Asp Ser
             340                 345                 350

 tgt cca tga                                                         1065
 Cys Pro 






      <210> 230
      <211> 5279
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1501)..(4782)

      <400> 230
 ggcctgtgga gtttcttgga caggggccgc ggggctccag gacggcgccc ttagcgacac     60

 catggcccga aatgcagaaa aggccatgac ggccttagca agatttcgcc aggctcagct    120

 ggaagaggga aaagtgaagg aacgaagacc ctttctggcc tcagaatgta ctgaactgcc    180

 taaagctgag aagtggagac gacagatcat tggagagatc tctaaaaaag tggctcagat    240

 tcagaatgct ggtttaggtg aatttcgaat tcgtgacctg aatgatgaaa ttaacaagct    300

 gctaagggag aaaggacact gggaggtccg gataaaggag ctgggaggtc ctgattatgg    360

 aaaagttggc cctaaaatgc tggatcatga aggaaaagaa gtcccaggaa accgaggtta    420

 caagtacttt ggagcagcaa aagatttgcc tggtgttaga gagctgtttg aaaaagaacc    480

 tcttcctcct cccagaaaga cacgtgctga gctcatgaag gcaatcgatt ttgagtacta    540

 tggttaccta gatgaagatg atggtgttat tgtgcctttg gaacaggaat atgaaaagaa    600

 actcagagcc gagttagtgg aaaagtggaa agcagagaga gaggctcggc tggcaagagg    660

 agaaaaggaa gaggaggagg aagaggagga agagatcaac atctatgcag tcaccgagga    720

 ggagtcggac gaggaaggca gccaggagaa aggaggggac gacagccagc agaagttcat    780

 tgctcacgtc cctgttccct cgcagcaaga gattgaggag gcactggtgc gaaggaagaa    840

 aatggaactc ctccagaagt atgcaagcga gaccctgcag gcccaaagtg aagaagccag    900

 aaggctcctg ggctgcagat ctgggacacg gccggccagg agcggttccg caccatcacc    960

 cagagctact accgcagtgc caatggggcc atccttgcct acgacatcac caagaggagc   1020

 tccttcctgt cggtgcctca ctggattgag gatgtgagga agtatgcggg ctccaacatt   1080

 gtgcagctgc tgatcgggaa caagtcagac ctcagcgagc ttcgggaggt ctccttggct   1140

 gaggcacaga gcctggctga gcactatgac atcctgtgtg ccattgagac gtctgccaag   1200

 gactcgagca acgtggagga ggccttcctg agggtggcca cggagctcat catgcggcac   1260

 gggggcccct tgttcagcga gaagagcccc gaccacatcc agctgaacag caaggacatc   1320

 ggagaaggct ggggctgcgg gtgctgacca ggggccgggc cggcagactg ggggttcccc   1380

 acctccttgc tctccccagc ctgccaagcc cagccctcca gagccagccc tcctgggtac   1440

 cggcaactac agcagccggg tgaagctctg gagctctgca tcctgtggcc tggctgcggg   1500
                                                                 
 atg gag gct ctc ctt gag gaa ggg gaa gca gga tac cct ggc ggg cca     1548
 Met Glu Ala Leu Leu Glu Glu Gly Glu Ala Gly Tyr Pro Gly Gly Pro
   1               5                  10                  15

 ccc tgc cag cca gca gct ggc cct cca cca tct tca cat tcc aag act     1596
 Pro Cys Gln Pro Ala Ala Gly Pro Pro Pro Ser Ser His Ser Lys Thr
              20                  25                  30

 ggc ctg aac ccg ccg gtg tgg gcc aca gtg gga ggg gcc agc agt cct     1644
 Gly Leu Asn Pro Pro Val Trp Ala Thr Val Gly Gly Ala Ser Ser Pro
          35                  40                  45

 ccc tgt ccc atg cct gct ggc tct gac cgt ttc ctc tca tgg gtt tgc     1692
 Pro Cys Pro Met Pro Ala Gly Ser Asp Arg Phe Leu Ser Trp Val Cys
      50                  55                  60

 ttt acc tgt ggc agc agg ttg ctg ctt tcc agg gat gtg tcc agt gcc     1740
 Phe Thr Cys Gly Ser Arg Leu Leu Leu Ser Arg Asp Val Ser Ser Ala
  65                  70                  75                  80

 ctg ggt tct tcc cgg tca tcc tgg ggc tct gca cag agc agc aga gct     1788
 Leu Gly Ser Ser Arg Ser Ser Trp Gly Ser Ala Gln Ser Ser Arg Ala
                  85                  90                  95

 aga gcc atg aga ccc aca gac ttg gtg cct gag cgc agc tcc agg gaa     1836
 Arg Ala Met Arg Pro Thr Asp Leu Val Pro Glu Arg Ser Ser Arg Glu
             100                 105                 110

 gcc cca gcc cct tcc agg cgg gga acc tgc ttc ctg cct tca ctg ccc     1884
 Ala Pro Ala Pro Ser Arg Arg Gly Thr Cys Phe Leu Pro Ser Leu Pro
         115                 120                 125

 ccg cag cac tca cag aca tct ccc tgg gca gag cct gcg tca tca cgt     1932
 Pro Gln His Ser Gln Thr Ser Pro Trp Ala Glu Pro Ala Ser Ser Arg
     130                 135                 140

 cgt tgc ctg ggc tgc cgt ccg cgg aaa ttt gaa atg gct gac ggg tcg     1980
 Arg Cys Leu Gly Cys Arg Pro Arg Lys Phe Glu Met Ala Asp Gly Ser
 145                 150                 155                 160

 ctg acg ggc ggc ggt ctg gag gca gcg gcc atg gcg ccg gag cgc acg     2028
 Leu Thr Gly Gly Gly Leu Glu Ala Ala Ala Met Ala Pro Glu Arg Thr
                 165                 170                 175

 ggc tgg gcg gtg gag cag gag ctg gcg tct ctg gag aaa ggt ttg ttc     2076
 Gly Trp Ala Val Glu Gln Glu Leu Ala Ser Leu Glu Lys Gly Leu Phe
             180                 185                 190

 caa gat gaa gat tca tgc agt gat tgt agc tac cgt gat aaa cca ggt     2124
 Gln Asp Glu Asp Ser Cys Ser Asp Cys Ser Tyr Arg Asp Lys Pro Gly
         195                 200                 205

 tct agt tta caa agt ttt atg cca gaa gga aaa acc ttt ttc cca gaa     2172
 Ser Ser Leu Gln Ser Phe Met Pro Glu Gly Lys Thr Phe Phe Pro Glu
     210                 215                 220

 att ttc caa aca aat caa ctt ttg ttc tat gag cga ttc aga gcc tat     2220
 Ile Phe Gln Thr Asn Gln Leu Leu Phe Tyr Glu Arg Phe Arg Ala Tyr
 225                 230                 235                 240

 caa gat tac att tta gct gac tgc aag gcc tct gag gta cag gaa ttc     2268
 Gln Asp Tyr Ile Leu Ala Asp Cys Lys Ala Ser Glu Val Gln Glu Phe
                 245                 250                 255

 aca gct gag ttc ttg gag aag gtc ctt gag cca tct gga tgg cgg gca     2316
 Thr Ala Glu Phe Leu Glu Lys Val Leu Glu Pro Ser Gly Trp Arg Ala
             260                 265                 270

 gtc tgg cac act aat gtg ttc aag gtg ctg gtt gag atc aca gat gtg     2364
 Val Trp His Thr Asn Val Phe Lys Val Leu Val Glu Ile Thr Asp Val
         275                 280                 285

 gac ttt gca gcc ttg aag gca gtg gtg agg ctt gct gaa cca tac ctc     2412
 Asp Phe Ala Ala Leu Lys Ala Val Val Arg Leu Ala Glu Pro Tyr Leu
     290                 295                 300

 tgt gac tct caa gtg agc act ttt acc atg gag tgc atg aag gag ctc     2460
 Cys Asp Ser Gln Val Ser Thr Phe Thr Met Glu Cys Met Lys Glu Leu
 305                 310                 315                 320

 ctt gat ctg aag gag cat cgg ttg ccc ctg cag gag ctg tgg gtg gtg     2508
 Leu Asp Leu Lys Glu His Arg Leu Pro Leu Gln Glu Leu Trp Val Val
                 325                 330                 335

 ttt gat gat tca gga gtg ttt gac cag aca gcc ctt gca att gag cat     2556
 Phe Asp Asp Ser Gly Val Phe Asp Gln Thr Ala Leu Ala Ile Glu His
             340                 345                 350

 gtc aga ttt ttc tac caa aac att tgg agg agt tgg gat gaa gaa gag     2604
 Val Arg Phe Phe Tyr Gln Asn Ile Trp Arg Ser Trp Asp Glu Glu Glu
         355                 360                 365

 gag gat gaa tac gat tat ttt gtc aga tgt gtt gaa cct cga tta aga     2652
 Glu Asp Glu Tyr Asp Tyr Phe Val Arg Cys Val Glu Pro Arg Leu Arg
     370                 375                 380

 ttg tat gtg ttt ggt tat cag aag aat tct aac atc caa gca aag ggt     2700
 Leu Tyr Val Phe Gly Tyr Gln Lys Asn Ser Asn Ile Gln Ala Lys Gly
 385                 390                 395                 400

 gtc cgt tcc agc ggt cag aag atc act cat gtg gtc tcc tcc acc atg     2748
 Val Arg Ser Ser Gly Gln Lys Ile Thr His Val Val Ser Ser Thr Met
                 405                 410                 415

 atg gct ggt ctc ctg cgg tcc ctg ctt acg gac agg ctt tgc cag gag     2796
 Met Ala Gly Leu Leu Arg Ser Leu Leu Thr Asp Arg Leu Cys Gln Glu
             420                 425                 430

 cct ggt gag gaa gaa aga gaa att cag ttc cat agt gat cca ttg tct     2844
 Pro Gly Glu Glu Glu Arg Glu Ile Gln Phe His Ser Asp Pro Leu Ser
         435                 440                 445

 gct ata aat gcc tgc ttc gaa ggt gac act gtt att gtt tgt cct ggc     2892
 Ala Ile Asn Ala Cys Phe Glu Gly Asp Thr Val Ile Val Cys Pro Gly
     450                 455                 460

 cat tat gtg gta cat ggc act ttc tcc att gct gac tcc att gag ttg     2940
 His Tyr Val Val His Gly Thr Phe Ser Ile Ala Asp Ser Ile Glu Leu
 465                 470                 475                 480

 gaa ggt ttg ttc caa gat gaa gat tca tgc agt gat tgt agc tac cgt     2988
 Glu Gly Leu Phe Gln Asp Glu Asp Ser Cys Ser Asp Cys Ser Tyr Arg
                 485                 490                 495

 gat aaa cca ggt tct agt tta caa agt ttt atg cca gaa gga aaa acc     3036
 Asp Lys Pro Gly Ser Ser Leu Gln Ser Phe Met Pro Glu Gly Lys Thr
             500                 505                 510

 ttt ttc cca gaa att ttc caa aca aat caa ctt ttg ttc tat gag cga     3084
 Phe Phe Pro Glu Ile Phe Gln Thr Asn Gln Leu Leu Phe Tyr Glu Arg
         515                 520                 525

 ttc aga gcc tat caa gat tac att tta gcc tgg ctc aga gct gac ttc     3132
 Phe Arg Ala Tyr Gln Asp Tyr Ile Leu Ala Trp Leu Arg Ala Asp Phe
     530                 535                 540

 ctt gcc cat ctc agc aga aca aga tcc cca ccc ctg cta gtt att ctc     3180
 Leu Ala His Leu Ser Arg Thr Arg Ser Pro Pro Leu Leu Val Ile Leu
 545                 550                 555                 560

 tgt cac cta ctg gtt atc att gtg ttt gtt gat ctc cct gat tac agt     3228
 Cys His Leu Leu Val Ile Ile Val Phe Val Asp Leu Pro Asp Tyr Ser
                 565                 570                 575

 gta agc tcc atg agg atc aca gat gtg gac ttt gca gcc ttg aag gca     3276
 Val Ser Ser Met Arg Ile Thr Asp Val Asp Phe Ala Ala Leu Lys Ala
             580                 585                 590

 gtg gtg agg ctt gct gaa cca tac ctc tgt gac tct caa gtg agc act     3324
 Val Val Arg Leu Ala Glu Pro Tyr Leu Cys Asp Ser Gln Val Ser Thr
         595                 600                 605

 ttt acc atg gag tgc atg aag gag ctc ctt gat ctg aag gag cat cgg     3372
 Phe Thr Met Glu Cys Met Lys Glu Leu Leu Asp Leu Lys Glu His Arg
     610                 615                 620

 ttg ccc ctg cag gag ctg tgg gtg gtg ttt gat gat tca gga gtg ttt     3420
 Leu Pro Leu Gln Glu Leu Trp Val Val Phe Asp Asp Ser Gly Val Phe
 625                 630                 635                 640

 gac cag aca gcc ctt gca att gag cat gtc agg cat tat gac att ctt     3468
 Asp Gln Thr Ala Leu Ala Ile Glu His Val Arg His Tyr Asp Ile Leu
                 645                 650                 655

 gaa gac cga gtt cca tca gga ctt att gtt gac tac cac aat ctg ttg     3516
 Glu Asp Arg Val Pro Ser Gly Leu Ile Val Asp Tyr His Asn Leu Leu
             660                 665                 670

 tct caa tgt gag gag agt tac agg aaa ttt tta aat ctg aga agc agt     3564
 Ser Gln Cys Glu Glu Ser Tyr Arg Lys Phe Leu Asn Leu Arg Ser Ser
         675                 680                 685

 ttg tca aat tgt aac tct gat tcc gag cag gaa aat atc tcc atg gtg     3612
 Leu Ser Asn Cys Asn Ser Asp Ser Glu Gln Glu Asn Ile Ser Met Val
     690                 695                 700

 gaa ggg tta aaa ttg tat tcg gag atg gaa cag ttg aaa caa aag ctg     3660
 Glu Gly Leu Lys Leu Tyr Ser Glu Met Glu Gln Leu Lys Gln Lys Leu
 705                 710                 715                 720

 aaa ctc att gag aat cct ttg ttg agg tat gtg ttt ggt tat cag aag     3708
 Lys Leu Ile Glu Asn Pro Leu Leu Arg Tyr Val Phe Gly Tyr Gln Lys
                 725                 730                 735

 aat tct aac atc caa gca aag ggt gtc cgt tcc agc ggt cag aag atc     3756
 Asn Ser Asn Ile Gln Ala Lys Gly Val Arg Ser Ser Gly Gln Lys Ile
             740                 745                 750

 act cat gtg gtc tcc tcc acc atg atg gct ggt ctc ctg cgg tcc ctg     3804
 Thr His Val Val Ser Ser Thr Met Met Ala Gly Leu Leu Arg Ser Leu
         755                 760                 765

 ctt acg gac agg ctt tgc cag gag cct ggt gag gaa gaa aga gaa att     3852
 Leu Thr Asp Arg Leu Cys Gln Glu Pro Gly Glu Glu Glu Arg Glu Ile
     770                 775                 780

 cag ttc cat agt gat cca ttg tct gct ata aat gcc tgc ttc gaa ggt     3900
 Gln Phe His Ser Asp Pro Leu Ser Ala Ile Asn Ala Cys Phe Glu Gly
 785                 790                 795                 800

 gac act gtt att gtt tgt cct ggc cat tat gtg gta cat ggc act ttc     3948
 Asp Thr Val Ile Val Cys Pro Gly His Tyr Val Val His Gly Thr Phe
                 805                 810                 815

 tcc att gct gac tcc att gag ttg gaa gga tat ggc cta cca gat gac     3996
 Ser Ile Ala Asp Ser Ile Glu Leu Glu Gly Tyr Gly Leu Pro Asp Asp
             820                 825                 830

 att gtg ata gaa aag agg ggc aaa ggc gac act ttt gtg gac tgc act     4044
 Ile Val Ile Glu Lys Arg Gly Lys Gly Asp Thr Phe Val Asp Cys Thr
         835                 840                 845

 ggt gct gat att aaa atc tca ggc ata aaa ttt gtt cag cat gat gct     4092
 Gly Ala Asp Ile Lys Ile Ser Gly Ile Lys Phe Val Gln His Asp Ala
     850                 855                 860

 gta gag gga atc tta att gtt cac cgt ggt aag act acg ctg gaa aac     4140
 Val Glu Gly Ile Leu Ile Val His Arg Gly Lys Thr Thr Leu Glu Asn
 865                 870                 875                 880

 tgt gtg ctg cag tgt gag acg acc gga gtc aca gtg cgg aca tca gca     4188
 Cys Val Leu Gln Cys Glu Thr Thr Gly Val Thr Val Arg Thr Ser Ala
                 885                 890                 895

 gag ttt cta atg aag aac tcg gat tta tat ggc gcc aag ggt gct ggt     4236
 Glu Phe Leu Met Lys Asn Ser Asp Leu Tyr Gly Ala Lys Gly Ala Gly
             900                 905                 910

 ata gaa atc tac cct ggg agt cag tgc acc ctg agt gac aat ggg atc     4284
 Ile Glu Ile Tyr Pro Gly Ser Gln Cys Thr Leu Ser Asp Asn Gly Ile
         915                 920                 925

 cat cac tgc aag gaa ggg atc ctc att aag gac ttc tta gat gaa cat     4332
 His His Cys Lys Glu Gly Ile Leu Ile Lys Asp Phe Leu Asp Glu His
     930                 935                 940

 tat gac att ccc aag ata tcc atg gtg aat aat ata ata cat aat aat     4380
 Tyr Asp Ile Pro Lys Ile Ser Met Val Asn Asn Ile Ile His Asn Asn
 945                 950                 955                 960

 gaa ggt tat ggt gtt gtc ttg gtg aaa cct aca atc ttc tct gac ctg     4428
 Glu Gly Tyr Gly Val Val Leu Val Lys Pro Thr Ile Phe Ser Asp Leu
                 965                 970                 975

 caa gaa aat gct gaa gat gga act gaa gaa aat aaa gcg ctt aaa att     4476
 Gln Glu Asn Ala Glu Asp Gly Thr Glu Glu Asn Lys Ala Leu Lys Ile
             980                 985                 990

 cag aca agt gga gag cca gat gtg gct gaa aga gtg gat cta gaa gag     4524
 Gln Thr Ser Gly Glu Pro Asp Val Ala Glu Arg Val Asp Leu Glu Glu
         995                1000                1005

 ctg att gag tgt gca act ggt aaa atg gag ctt tgt gca aga act gac     4572
 Leu Ile Glu Cys Ala Thr Gly Lys Met Glu Leu Cys Ala Arg Thr Asp
    1010                1015                1020

 cct tct gag caa gtc gag gga aat tgt gaa att gta aat gaa cta att     4620
 Pro Ser Glu Gln Val Glu Gly Asn Cys Glu Ile Val Asn Glu Leu Ile
1025                1030                1035                1040

 gct gcc tcc aca cag aaa ggc cag ata aag aag aaa agg ttg agt gaa     4668
 Ala Ala Ser Thr Gln Lys Gly Gln Ile Lys Lys Lys Arg Leu Ser Glu
                1045                1050                1055

 ctg ggg atc acg caa gct gat gac aac tta atg tca cag gag atg ttt     4716
 Leu Gly Ile Thr Gln Ala Asp Asp Asn Leu Met Ser Gln Glu Met Phe
            1060                1065                1070

 gtt ggg att gtg ggg aac cag ttc aag tgg aat ggg aaa ggt agt ttt     4764
 Val Gly Ile Val Gly Asn Gln Phe Lys Trp Asn Gly Lys Gly Ser Phe
        1075                1080                1085

 ggc aca ttt ctt ttc tga ctacag tgatgtaagt agatagcaaa atactggatt     4818
 Gly Thr Phe Leu Phe 
    1090

 ttgcacatgc tgccctaaga atcactgctg ccattgtagt ttgctgtatt gtctgtattt   4878

 tatatttgat tatttgggct tgagtgaaag gtagatttat ttccatttgc aggtgttgca   4938

 cataaaacac tccctcttta taagaaaaat cataaatgca tataaaatag aaaatatttg   4998

 gagattgctt atctgaaagt cttgctttct tatacacatg gttctctcat attaagcctg   5058

 gtggtaactt tttagtgtaa ttacctttag cacttcaaag acgaggaagt aaggaaggga   5118

 atgcaagact agtgcataaa aatgcaatag gtgtcatatg tacagcattc ttcttagagt   5178

 tgccttttca tcccaattac agtgagtctg atttccatcc tgtatttgca taatacttgt   5238

 cttaaaataa aagcttttat gattgggaaa aaaaaaaaaa a                       5279




      <210> 231
      <211> 1909
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(1862)

      <400> 231
 acgcgggata cagggagggg ccatgtgcga accagggaga cctcatcttc caaccaagct     60

 tgctgggctt gcatttaatc aatgcatggc cagagaacag gagcggaaca ttgcctagta    120

 gaccctgagg ctttacaaca gtgctactga cccct   atg agc ctg atg ctg gat     173
                                          Met Ser Leu Met Leu Asp
                                            1               5

 gac caa ccc cct atg gag gcc cag tat gca gag gag ggc cca gga cct      221
 Asp Gln Pro Pro Met Glu Ala Gln Tyr Ala Glu Glu Gly Pro Gly Pro
              10                  15                  20

 ggg atc ttc aga gca gag cct gga gac cag cag cat ccc att tct cag      269
 Gly Ile Phe Arg Ala Glu Pro Gly Asp Gln Gln His Pro Ile Ser Gln
          25                  30                  35

 gcg gtg tgc tgg cgt tcc atg cga cgt ggc tgt gca gtg ctg gga gcc      317
 Ala Val Cys Trp Arg Ser Met Arg Arg Gly Cys Ala Val Leu Gly Ala
      40                  45                  50

 ctg ggg ctg ctg gcc ggt gca ggt gtt ggc tca tgg ctc cta gtg ctg      365
 Leu Gly Leu Leu Ala Gly Ala Gly Val Gly Ser Trp Leu Leu Val Leu
  55                  60                  65                  70

 tat ctg tgt cct gct gcc tct cag ccc att tcc ggg acc ttg cag gat      413
 Tyr Leu Cys Pro Ala Ala Ser Gln Pro Ile Ser Gly Thr Leu Gln Asp
                  75                  80                  85

 gag gag ata act ttg agc tgc tca gag gcc agc gct gag gaa gct ctg      461
 Glu Glu Ile Thr Leu Ser Cys Ser Glu Ala Ser Ala Glu Glu Ala Leu
              90                  95                 100

 ctc cct gca ctc ccc aaa aca gta tct ttc aga ata aac agc gaa gac      509
 Leu Pro Ala Leu Pro Lys Thr Val Ser Phe Arg Ile Asn Ser Glu Asp
         105                 110                 115

 ttc ttg ctg gaa gcg caa gtg agg gat cag cca cgc tgg ctc ctg gtc      557
 Phe Leu Leu Glu Ala Gln Val Arg Asp Gln Pro Arg Trp Leu Leu Val
     120                 125                 130

 tgc cat gag ggc tgg agc ccc gcc ctg ggg ctg cag atc tgc tgg agc      605
 Cys His Glu Gly Trp Ser Pro Ala Leu Gly Leu Gln Ile Cys Trp Ser
 135                 140                 145                 150

 ctt ggg cat ctc aga ctc act cac cac aag gga gta aac ctc act gac      653
 Leu Gly His Leu Arg Leu Thr His His Lys Gly Val Asn Leu Thr Asp
                 155                 160                 165

 atc aaa ctc aac agt tcc cag gag ttt gct cag ctc tct cct aga ctg      701
 Ile Lys Leu Asn Ser Ser Gln Glu Phe Ala Gln Leu Ser Pro Arg Leu
             170                 175                 180

 gga ggc ttc ctg gag gag gcg tgg cag ccc agg aac aac tgc act tct      749
 Gly Gly Phe Leu Glu Glu Ala Trp Gln Pro Arg Asn Asn Cys Thr Ser
         185                 190                 195

 ggt caa gtt gtt tcc ctc aga tgc tct gag tgt gga gcg agg ccc ctg      797
 Gly Gln Val Val Ser Leu Arg Cys Ser Glu Cys Gly Ala Arg Pro Leu
     200                 205                 210

 gct tcc cgg ata gtt ggt ggg cag tct gtg gct cct ggg cgc tgg ccg      845
 Ala Ser Arg Ile Val Gly Gly Gln Ser Val Ala Pro Gly Arg Trp Pro
 215                 220                 225                 230

 tgg cag gcc agc gtg gcc ctg ggc ttc cgg cac acg tgt ggg ggc tct      893
 Trp Gln Ala Ser Val Ala Leu Gly Phe Arg His Thr Cys Gly Gly Ser
                 235                 240                 245

 gtg cta gcg cca cgc tgg gtg gtg act gct gca cat tgt atg cac agg      941
 Val Leu Ala Pro Arg Trp Val Val Thr Ala Ala His Cys Met His Arg
             250                 255                 260

 caa gtc tct gtg gct gct gag gac aga gag cct cag ttg ccc ttt ctg      989
 Gln Val Ser Val Ala Ala Glu Asp Arg Glu Pro Gln Leu Pro Phe Leu
         265                 270                 275

 ttc ggc tgt tgg tat gtc ctg tat caa atg ttc gtg tcc aac tgt ctc     1037
 Phe Gly Cys Trp Tyr Val Leu Tyr Gln Met Phe Val Ser Asn Cys Leu
     280                 285                 290

 cag ctt ttt gct cca aaa ggt cct gca gca ttt att aag cac cta ctg     1085
 Gln Leu Phe Ala Pro Lys Gly Pro Ala Ala Phe Ile Lys His Leu Leu
 295                 300                 305                 310

 cat gcc cag tgt ctt gcc ggc tgc tgg ggt gat act aag agg cat agt     1133
 His Ala Gln Cys Leu Ala Gly Cys Trp Gly Asp Thr Lys Arg His Ser
                 315                 320                 325

 ctg tgg ggc ctg gga gct cac cgc ctg ctg acg gcc ccc cca cca atg     1181
 Leu Trp Gly Leu Gly Ala His Arg Leu Leu Thr Ala Pro Pro Pro Met
             330                 335                 340

 gct gct ctg gcc agc ttc ctc cac ctg cta cct tgc tta gga aca cct     1229
 Ala Ala Leu Ala Ser Phe Leu His Leu Leu Pro Cys Leu Gly Thr Pro
         345                 350                 355

 ctt ctg ccc ctt cct tcc ccg ctc agc atg gcc cct gtg tgc agt ttc     1277
 Leu Leu Pro Leu Pro Ser Pro Leu Ser Met Ala Pro Val Cys Ser Phe
     360                 365                 370

 agg ctg gcc cgc ctg tcc agc tgg cgg gtt cat gcg ggg ctg gtc agc     1325
 Arg Leu Ala Arg Leu Ser Ser Trp Arg Val His Ala Gly Leu Val Ser
 375                 380                 385                 390

 cac agt gcc gtc agg ccc cac caa ggg gct ctg gtg gag agg att atc     1373
 His Ser Ala Val Arg Pro His Gln Gly Ala Leu Val Glu Arg Ile Ile
                 395                 400                 405

 cca cac ccc ctc tac agt gcc cag aat cat gac tac gac gtc gcc ctc     1421
 Pro His Pro Leu Tyr Ser Ala Gln Asn His Asp Tyr Asp Val Ala Leu
             410                 415                 420

 ctg agg ctc cag acc gct ctc aac ttc tca gac act gtg ggc gct gtg     1469
 Leu Arg Leu Gln Thr Ala Leu Asn Phe Ser Asp Thr Val Gly Ala Val
         425                 430                 435

 tgc ctg ccg gcc aag gaa cag cat ttt ccg aag ggc tcg cgg tgc tgg     1517
 Cys Leu Pro Ala Lys Glu Gln His Phe Pro Lys Gly Ser Arg Cys Trp
     440                 445                 450

 gtg tct ggc tgg ggc cac acc cac cct agc cat act tac agc tcg gat     1565
 Val Ser Gly Trp Gly His Thr His Pro Ser His Thr Tyr Ser Ser Asp
 455                 460                 465                 470

 atg ctc cag gac acg gtg gtg ccc ttg ttc agc act cag ctc tgc aac     1613
 Met Leu Gln Asp Thr Val Val Pro Leu Phe Ser Thr Gln Leu Cys Asn
                 475                 480                 485

 agc tct tgc gtg tac agc gga gcc ctc acc ccc cgc atg ctt tgc gct     1661
 Ser Ser Cys Val Tyr Ser Gly Ala Leu Thr Pro Arg Met Leu Cys Ala
             490                 495                 500

 ggc tac ctg gac gga agg gct gat gca tgc cag gga gat agc ggg ggc     1709
 Gly Tyr Leu Asp Gly Arg Ala Asp Ala Cys Gln Gly Asp Ser Gly Gly
         505                 510                 515

 ccc cta gtg tgc cca gat ggg gac aca tgg cgc cta gtg ggg gtg gtc     1757
 Pro Leu Val Cys Pro Asp Gly Asp Thr Trp Arg Leu Val Gly Val Val
     520                 525                 530

 agc tgg ggg cgt gcg tgc gca gag ccc aat cac cca ggt gtc tac gcc     1805
 Ser Trp Gly Arg Ala Cys Ala Glu Pro Asn His Pro Gly Val Tyr Ala
 535                 540                 545                 550

 aag gta gct gag ttt ctg gac tgg atc cat gac act gct cag gac tcc     1853
 Lys Val Ala Glu Phe Leu Asp Trp Ile His Asp Thr Ala Gln Asp Ser
                 555                 560                 565

 ctc ctc tga gtcctgc tgtttcctcc agtctcactg cacaccactg cctcatgctt     1909
 Leu Leu 






      <210> 232
      <211> 3346
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(3346)

      <400> 232
 gcgctccggc cggaggagac ggagcggagc ggatcatgag aaggcaaaac ggggagaggg     60

 cgcgagtcgg agcccccggg gagtgctaaa agatggaggg cagcaggagc ctgggactcg    120

 ggagcgggac ccggacaaag ccacccgctt ccgg    atg gag gag ctg aga ctg     172
                                          Met Glu Glu Leu Arg Leu
                                            1               5

 acc agc acc acg ttt gcg ctg acg gga gac tca gca cac aac caa gcc      220
 Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln Ala
              10                  15                  20

 atg gtc cac tgg tct ggc cac aac agc agc gtg att ctc att ttg aca      268
 Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu Thr
          25                  30                  35

 aag ctc tat gac tat aac ctg ggg agc atc aca gag agc tcg ctt tgg      316
 Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu Trp
      40                  45                  50

 agg tca acc gat tat gga aca acc tat gag aag ctg aat gat aaa gtt      364
 Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys Val
  55                  60                  65                  70

 ggt ttg aaa acc att ttg agc tat ctc tat gtg tgt cct acc aac aag      412
 Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn Lys
                  75                  80                  85

 cgt aag ata atg tta ctc aca gac ccg gag att gag agc agt tta ttg      460
 Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Ser Leu Leu
              90                  95                 100

 atc agc tca gat gaa ggg gca act tat caa aag tac cgg ctg aac ttc      508
 Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Leu Asn Phe
         105                 110                 115

 tac att caa agc ttg ctt ttt cac ccc aaa caa gaa gac tgg att ctg      556
 Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile Leu
     120                 125                 130

 gca tac agt caa gac caa aag tta tac agc tct gct gaa ttt ggg aga      604
 Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly Arg
 135                 140                 145                 150

 aga tgg cag ctt atc caa gaa ggg gtt gta cca aac agg ttc tac tgg      652
 Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr Trp
                 155                 160                 165

 tct gtg atg ggg tca aat aaa gaa cca gac ctt gtg cat ctt gag gcc      700
 Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu Ala
             170                 175                 180

 aga act gtg gat ggt cat tca cat tat cta act tgc cga atg cag aac      748
 Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln Asn
         185                 190                 195

 tgt aca gag gcc aac agg aat cag cct ttt cca ggc tac att gac cca      796
 Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp Pro
     200                 205                 210

 gac tct ttg att gtt cag gat cat tat gtg ttt gtt cag ctg aca tca      844
 Asp Ser Leu Ile Val Gln Asp His Tyr Val Phe Val Gln Leu Thr Ser
 215                 220                 225                 230

 gga ggg cgg cca cat tac tac gtg tcc tac cga agg aat gca ttt gcc      892
 Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr Arg Arg Asn Ala Phe Ala
                 235                 240                 245

 caa atg aag ctt ccg aaa tat gct ttg ccc aag gac atg cat gtt atc      940
 Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Met His Val Ile
             250                 255                 260

 agc acc gat gag aat cag gtg ttc gca gcg gtc caa gaa tgg aac cag      988
 Ser Thr Asp Glu Asn Gln Val Phe Ala Ala Val Gln Glu Trp Asn Gln
         265                 270                 275

 aat gac acg tac aac ctc tac atc tca gac aca cgt ggt gtc tac ttc     1036
 Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp Thr Arg Gly Val Tyr Phe
     280                 285                 290

 acc ctg gcc ttg gag aat gtc cag agc agc aga ggc cct gag ggc aac     1084
 Thr Leu Ala Leu Glu Asn Val Gln Ser Ser Arg Gly Pro Glu Gly Asn
 295                 300                 305                 310

 atc atg atc gac ctc tat gag gta gca ggg ata aag gga atg ttc ttg     1132
 Ile Met Ile Asp Leu Tyr Glu Val Ala Gly Ile Lys Gly Met Phe Leu
                 315                 320                 325

 gct aac aag aag att gac aac caa gtg aag act ttc atc aca tat aac     1180
 Ala Asn Lys Lys Ile Asp Asn Gln Val Lys Thr Phe Ile Thr Tyr Asn
             330                 335                 340

 aaa ggc aga gac tgg cgt ttg ctg cag gcg ccg gac acg gat cta agg     1228
 Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala Pro Asp Thr Asp Leu Arg
         345                 350                 355

 ggg gac ccc gtg cac tgc ttg ctg ccc tat tgc tca cta cac ctt cac     1276
 Gly Asp Pro Val His Cys Leu Leu Pro Tyr Cys Ser Leu His Leu His
     360                 365                 370

 ctg aag gtc tct gag aat ccc tac aca tca ggg atc att gcc agc aaa     1324
 Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser Gly Ile Ile Ala Ser Lys
 375                 380                 385                 390

 gac aca gct cca agc atc ata gtg gca tca ggt aat ata ggt tct gaa     1372
 Asp Thr Ala Pro Ser Ile Ile Val Ala Ser Gly Asn Ile Gly Ser Glu
                 395                 400                 405

 ttg tca gac act gac atc agc atg ttt gtc tct tca gat gca ggg aac     1420
 Leu Ser Asp Thr Asp Ile Ser Met Phe Val Ser Ser Asp Ala Gly Asn
             410                 415                 420

 acc tgg aga cag atc ttt gaa gaa gag cac agt gtt ttg tac ctg gat     1468
 Thr Trp Arg Gln Ile Phe Glu Glu Glu His Ser Val Leu Tyr Leu Asp
         425                 430                 435

 caa ggt gga gtc ctg gtt gct atg aaa cac aca tct ctc cca att cga     1516
 Gln Gly Gly Val Leu Val Ala Met Lys His Thr Ser Leu Pro Ile Arg
     440                 445                 450

 cat ctt tgg ttg agt ttt gat gaa ggg aga tct tgg agc aaa tac agt     1564
 His Leu Trp Leu Ser Phe Asp Glu Gly Arg Ser Trp Ser Lys Tyr Ser
 455                 460                 465                 470

 ttc aca tct att cca ctt ttt gtg gat ggg gtt ctg ggt gag cct gga     1612
 Phe Thr Ser Ile Pro Leu Phe Val Asp Gly Val Leu Gly Glu Pro Gly
                 475                 480                 485

 gaa gag act ctc atc atg aca gtg ttt gga cac ttc agc cac cgc tct     1660
 Glu Glu Thr Leu Ile Met Thr Val Phe Gly His Phe Ser His Arg Ser
             490                 495                 500

 gaa tgg cag ctg gtc aaa gta gat tac aag tcc att ttt gat aga cgg     1708
 Glu Trp Gln Leu Val Lys Val Asp Tyr Lys Ser Ile Phe Asp Arg Arg
         505                 510                 515

 tgt gcc gaa gag gac tac aga cct tgg cag ctg cac agc cag ggg gaa     1756
 Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln Leu His Ser Gln Gly Glu
     520                 525                 530

 gca tgt atc atg gga gca aaa agg ata tat aag aag cga aaa tca gag     1804
 Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr Lys Lys Arg Lys Ser Glu
 535                 540                 545                 550

 cgg aag tgt atg caa gga aaa tat gca gga gct atg gaa tct gaa ccc     1852
 Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly Ala Met Glu Ser Glu Pro
                 555                 560                 565

 tgt gtc tgc act gag gct gat ttt gat tgc gac tat ggt tat gag cga     1900
 Cys Val Cys Thr Glu Ala Asp Phe Asp Cys Asp Tyr Gly Tyr Glu Arg
             570                 575                 580

 cac agc aat ggc cag tgc ctg ccg gca ttt tgg ttc aat cca tcc tct     1948
 His Ser Asn Gly Gln Cys Leu Pro Ala Phe Trp Phe Asn Pro Ser Ser
         585                 590                 595

 ctg tca aag gat tgc agc ttg gga cag agt tac ctc aat agt act ggg     1996
 Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser Tyr Leu Asn Ser Thr Gly
     600                 605                 610

 tac agg aag gtg gtt tcc aat aat tgc act gat ggc gta agg gaa cag     2044
 Tyr Arg Lys Val Val Ser Asn Asn Cys Thr Asp Gly Val Arg Glu Gln
 615                 620                 625                 630

 tac act gcc aaa ccg cag aag tgc cca ggg aaa gcc ccg cgg ggg ctg     2092
 Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly Lys Ala Pro Arg Gly Leu
                 635                 640                 645

 cgg ata gtc acg gct gat gga aag ctg aca gcg gaa caa gga cac aac     2140
 Arg Ile Val Thr Ala Asp Gly Lys Leu Thr Ala Glu Gln Gly His Asn
             650                 655                 660

 gtc act ctc atg gtg caa tta gaa gag ggt gat gtt cag cgg aca ctc     2188
 Val Thr Leu Met Val Gln Leu Glu Glu Gly Asp Val Gln Arg Thr Leu
         665                 670                 675

 atc caa gtg gac ttt ggc gat ggt atc gcg gtg tct tac gtc aat ctc     2236
 Ile Gln Val Asp Phe Gly Asp Gly Ile Ala Val Ser Tyr Val Asn Leu
     680                 685                 690

 agc tcc atg gaa gat ggg atc aaa cac gtc tat cag aac gtg ggc att     2284
 Ser Ser Met Glu Asp Gly Ile Lys His Val Tyr Gln Asn Val Gly Ile
 695                 700                 705                 710

 ttc cgt gtg acc gtg cag gtg gac aac agt ctg ggt tct gac agc gcc     2332
 Phe Arg Val Thr Val Gln Val Asp Asn Ser Leu Gly Ser Asp Ser Ala
                 715                 720                 725

 gtc ctg tac tta cat gta act tgt ccc ttg gag cac gtg cac ctg tct     2380
 Val Leu Tyr Leu His Val Thr Cys Pro Leu Glu His Val His Leu Ser
             730                 735                 740

 ctt ccc ttt gtc acc aca aag aac aaa gag gtc aat gcg acg gca gtg     2428
 Leu Pro Phe Val Thr Thr Lys Asn Lys Glu Val Asn Ala Thr Ala Val
         745                 750                 755

 ctg tgg ccc agc caa gtg ggc acc ctc act tac gtg tgg tgg tac gga     2476
 Leu Trp Pro Ser Gln Val Gly Thr Leu Thr Tyr Val Trp Trp Tyr Gly
     760                 765                 770

 aac aac acg gag cct ttg atc acc ttg gag gga agc ata tcc ttc aga     2524
 Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu Gly Ser Ile Ser Phe Arg
 775                 780                 785                 790

 ttt act tca gaa gga atg aat acc atc aca gtg cag gtc tca gct ggg     2572
 Phe Thr Ser Glu Gly Met Asn Thr Ile Thr Val Gln Val Ser Ala Gly
                 795                 800                 805

 aat gcc atc cta caa gac aca aag acc atc gca gta tat gag gaa ttc     2620
 Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile Ala Val Tyr Glu Glu Phe
             810                 815                 820

 cgg tct ctt cgc ttg tcc ttt tct cca aac ctg gat gac tac aac ccg     2668
 Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn Leu Asp Asp Tyr Asn Pro
         825                 830                 835

 gac atc cct gag tgg agg agg gac atc ggt cga gtc atc aaa aaa tcc     2716
 Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly Arg Val Ile Lys Lys Ser
     840                 845                 850

 ctg gtg gaa gcc aca ggg gtt cca ggc cag cac atc ctg gtg gcg gtg     2764
 Leu Val Glu Ala Thr Gly Val Pro Gly Gln His Ile Leu Val Ala Val
 855                 860                 865                 870

 ctc cct ggc tta ccc acc act gct gaa ctc ttt gtc cta ccc tat cag     2812
 Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu Phe Val Leu Pro Tyr Gln
                 875                 880                 885

 gat cca gct gga gaa aac aaa agg tca act gat gac ctg gag cag ata     2860
 Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr Asp Asp Leu Glu Gln Ile
             890                 895                 900

 tca gaa ttg ctg atc cac acg ctc aac caa aac tca gta cac ttc gag     2908
 Ser Glu Leu Leu Ile His Thr Leu Asn Gln Asn Ser Val His Phe Glu
         905                 910                 915

 ctg aag cca gga gtc cga gtc ctt gtc cat gct gct cac tta aca gcg     2956
 Leu Lys Pro Gly Val Arg Val Leu Val His Ala Ala His Leu Thr Ala
     920                 925                 930

 gcc ccc ctg gtg gac ctc act cca acc cac agt gga tct gcc atg ctg     3004
 Ala Pro Leu Val Asp Leu Thr Pro Thr His Ser Gly Ser Ala Met Leu
 935                 940                 945                 950

 atg ctg ctc tca gtg gtg ttt gtg ggg ctg gca gtg ttc gtc atc tac     3052
 Met Leu Leu Ser Val Val Phe Val Gly Leu Ala Val Phe Val Ile Tyr
                 955                 960                 965

 aag ttt aaa agg aag atc ccg ggg att aat gtt tat gcc cag atg cag     3100
 Lys Phe Lys Arg Lys Ile Pro Gly Ile Asn Val Tyr Ala Gln Met Gln
             970                 975                 980

 aat gag aaa gaa caa gag atg atc agt cca gtc agt cac tct gaa agc     3148
 Asn Glu Lys Glu Gln Glu Met Ile Ser Pro Val Ser His Ser Glu Ser
         985                 990                 995

 agg ccc aat gtc cct cag act gaa cta agg agg cct ggc cag ctt ata     3196
 Arg Pro Asn Val Pro Gln Thr Glu Leu Arg Arg Pro Gly Gln Leu Ile
    1000                1005                1010

 gat gag aag gtg gaa tcc cag ctc ata gac tgt ccc tta cca gaa gtt     3244
 Asp Glu Lys Val Glu Ser Gln Leu Ile Asp Cys Pro Leu Pro Glu Val
1015                1020                1025                1030

 gta aaa tgg act ttc tca tat ttc aat ggc tct ctc tct gcc tgt gaa     3292
 Val Lys Trp Thr Phe Ser Tyr Phe Asn Gly Ser Leu Ser Ala Cys Glu
                1035                1040                1045

 gta ggc atg gga atc caa caa cga ggt ata gag aat ctg acg ttc act     3340
 Val Gly Met Gly Ile Gln Gln Arg Gly Ile Glu Asn Leu Thr Phe Thr
            1050                1055                1060

 tgc tag                                                             3346
 Cys 






      <210> 233
      <211> 1848
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(1215)

      <400> 233
 ttctaagaaa tgctatttct gcttaagtgc tgctggattt ggaaatcatt ttcatgacta     60

 aatatttgtc tgcctggtga gagcccagcg tagggctgtg ctgtccgtag atactcaata    120

 ctgattaatg gatggccgtg catgtctgtg tgggagtcgt gtgcttagga tctgctcagc    180

 tctccgaaag caacagaa  atg gtg tgg gga aga aga aaa tca cag gat tgt     231
                      Met Val Trp Gly Arg Arg Lys Ser Gln Asp Cys
                        1               5                  10

 gat cca acc atg atc acg gct ttc tgg att gga ctt cat ctt ctg gag      279
 Asp Pro Thr Met Ile Thr Ala Phe Trp Ile Gly Leu His Leu Leu Glu
              15                  20                  25

 ggt cca caa ggt cca gtg ctg gca gca aac ctc acc att ttg tcc tcc      327
 Gly Pro Gln Gly Pro Val Leu Ala Ala Asn Leu Thr Ile Leu Ser Ser
          30                  35                  40

 aaa agg aag gtg act ttt aag aag caa tcc aga aga ggt ccc cgc cca      375
 Lys Arg Lys Val Thr Phe Lys Lys Gln Ser Arg Arg Gly Pro Arg Pro
      45                  50                  55

 acc ttc aaa att ctg tcc aaa agc aga caa gag gat cgc ccc gcg ctg      423
 Thr Phe Lys Ile Leu Ser Lys Ser Arg Gln Glu Asp Arg Pro Ala Leu
  60                  65                  70                  75

 agc cgg ctg gtg ggc agc agg agg cgc ctg atc gcc gcc ggg gcg ctg      471
 Ser Arg Leu Val Gly Ser Arg Arg Arg Leu Ile Ala Ala Gly Ala Leu
                  80                  85                  90

 ggg gtg gtg atg gtg ctg ctg ctg gtg atc ctc atc ccg gtg ctg atg      519
 Gly Val Val Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Met
              95                 100                 105

 ctg ggc acc tgc cgc atg gtc tgc gac ccc tac ggg ggc acc aag gcg      567
 Leu Gly Thr Cys Arg Met Val Cys Asp Pro Tyr Gly Gly Thr Lys Ala
         110                 115                 120

 ccc agc acc gct gcc acg ccc gac cgc ggc ctc atg cag tcc ctg ccc      615
 Pro Ser Thr Ala Ala Thr Pro Asp Arg Gly Leu Met Gln Ser Leu Pro
     125                 130                 135

 acc ttc atc cag ggc ccc aaa ggc gag gcc ggc agg ccc ggg aag gcg      663
 Thr Phe Ile Gln Gly Pro Lys Gly Glu Ala Gly Arg Pro Gly Lys Ala
 140                 145                 150                 155

 ggt ccg cgc ggg ccc ccc gga gag ccc ggg cca ccc ggc ccc atg ggg      711
 Gly Pro Arg Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly
                 160                 165                 170

 ccc ccg ggc gag aag ggc gag ccg ggc cgc caa ggc ctg ccg ggc ccg      759
 Pro Pro Gly Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro
             175                 180                 185

 ccc ggg gcg ccc ggc ctg aac gcg gcc ggg gcc atc agc gcc gcc acc      807
 Pro Gly Ala Pro Gly Leu Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr
         190                 195                 200

 tac agc acg ggg ccc aag atc gcc ttc tac gcc ggc ctc aag cgg cag      855
 Tyr Ser Thr Gly Pro Lys Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln
     205                 210                 215

 cat gaa ggc tac gag gtg ctc aag ttc gac gac gtg gtc acc aac ctc      903
 His Glu Gly Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu
 220                 225                 230                 235

 gga aac cac tac gac ccc acc acc ggc aag ttc acc tgc tcc atc ccg      951
 Gly Asn His Tyr Asp Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro
                 240                 245                 250

 ggc atc tac ttc ttc acc tac cac gtc ctg atg cgc gga ggg gac ggc      999
 Gly Ile Tyr Phe Phe Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly
             255                 260                 265

 acc agc atg tgg gct gat ctc tgc aaa aac aac cag gtg cgt gct agt     1047
 Thr Ser Met Trp Ala Asp Leu Cys Lys Asn Asn Gln Val Arg Ala Ser
         270                 275                 280

 gca att gcc caa gat gct gat cag aat tac gac tat gcc agt aac agt     1095
 Ala Ile Ala Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser
     285                 290                 295

 gtg gtt ctt cat ttg gag ccg gga gat gaa gtc tat atc aaa tta gat     1143
 Val Val Leu His Leu Glu Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp
 300                 305                 310                 315

 ggc ggg aaa gcc cat gga gga aac aac aac aaa tac agc acg ttt tct     1191
 Gly Gly Lys Ala His Gly Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser
                 320                 325                 330

 gga ttt att att tat gct gac tga taatgcagaa actaagctta ttattctgag    1245
 Gly Phe Ile Ile Tyr Ala Asp 
             335

 tttgaacact ggattcgtat ggctaacgtc agtgaatcaa ggatcccagg ggatgccaat   1305

 ggcagggcac ctcagttgtg tatatgtggg gaaatcaaat gctacctgac tcacatctgt   1365

 atcactcaga aacattatgt aaaaaatatc aaagcaagat aagcagatgt gtgatccact   1425

 accgccaaag caaatactcc ttatcgttag tgtccatgtg aatgaagtcc tatatagatc   1485

 acaaattttt atagacaaat ctaagacatt gaattatttc ttctatatat atgatacttt   1545

 ggtgtactgt gatcttgctg cttttatcca tatgtcagct ttggttcttg tgagtttacc   1605

 tgcttattat gatacttgga gtccattcat agtgtgggga agaatgattt ttgccctgca   1665

 ggagaaggtc taattgaaat aatgctgctt gtccccaaag aaattgtttg ccttgtactc   1725

 ttgttaacct tagagctaga cctgggaatg attcaacttc aagccttaac ctggaatttt   1785

 ctggatttga gggaattccc aagcctatga tctttttcac attttctttt tcttatatga   1845

 aat                                                                 1848




      <210> 234
      <211> 3372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (108)..(533)

      <400> 234
 ctgagctcgg cgcggagccc ggagcccgca gccgacagtc tcctgctccc gtacgctggg     60

 cgccagctcc ggccgtgctg cccggctgcc tgagagcgcg cccggcc  atg gag ccc     116
                                                      Met Glu Pro
                                                        1

 tcg cac aaa gac gcc gag acg gcg gcg gcg gcg gcg gcg gtg gcg gcg      164
 Ser His Lys Asp Ala Glu Thr Ala Ala Ala Ala Ala Ala Val Ala Ala
       5                  10                  15

 gcg gac ccc cgg ggg gcg tcc tcg tcc agc ggg gtg gtg gtg cag gtc      212
 Ala Asp Pro Arg Gly Ala Ser Ser Ser Ser Gly Val Val Val Gln Val
  20                  25                  30                  35

 cgc gag aag aag ggc ccc ctg cgc gcc gcc atc ccc tac atg ccc ttc      260
 Arg Glu Lys Lys Gly Pro Leu Arg Ala Ala Ile Pro Tyr Met Pro Phe
                  40                  45                  50

 ccc gtg gcc gtc atc tgc ctc ttc ctc aac act ttc gtg ccg gga ctg      308
 Pro Val Ala Val Ile Cys Leu Phe Leu Asn Thr Phe Val Pro Gly Leu
              55                  60                  65

 ggg aca ttc gtc tcg gcc ttc act gtg ctg tgc ggg gcc cgc acc gac      356
 Gly Thr Phe Val Ser Ala Phe Thr Val Leu Cys Gly Ala Arg Thr Asp
          70                  75                  80

 ctc ccg gac agg cat gtg tgc tgc gtc ttc tgg ctg aac att gca gca      404
 Leu Pro Asp Arg His Val Cys Cys Val Phe Trp Leu Asn Ile Ala Ala
      85                  90                  95

 gcc ctc atc caa atc ctc act gcc atc gtc atg gtg ggc tgg atc atg      452
 Ala Leu Ile Gln Ile Leu Thr Ala Ile Val Met Val Gly Trp Ile Met
 100                 105                 110                 115

 agc atc ttc tgg ggc atg gac atg gtc atc ctt gcc att tcc caa ggc      500
 Ser Ile Phe Trp Gly Met Asp Met Val Ile Leu Ala Ile Ser Gln Gly
                 120                 125                 130

 tac aag gag cag ggc atc cca cag cag ctg tga gcccacgg gagccgctgg      551
 Tyr Lys Glu Gln Gly Ile Pro Gln Gln Leu 
             135                 140

 ggagatccag gggggccctg tgagggctgc accaggcagc tttgggcaca aggaccttta    611

 catgttcttt tctgccattt tctggactgg gggtggaaag ggggtatttt taaaaatatt    671

 atttattttg aaaacgcatc tgcttttctc agcaggttgt gagggctgcc agcccctcct    731

 gctctggaaa gcactgtggg cgcaggcacc agagcatcag agagtggggt ggagatgaga    791

 acgcccacag agaggctggg atgctccggc aggctccaac tggccttgct gtacccactg    851

 cccaccgcaa aggcacgcca cgtctgctgg gccgggccac accgggccct gtctgggtga    911

 gcaggggctc accaagggga caggactgtg gtagacccgt cctgtgggac cccacctgcc    971

 tcaaaatctg gtgccccgag tgtttactgt gtggtctcct gggggcagca ccagggtgtg   1031

 ggtgaggatg gccaggctcc accctagcgt ggaaaggccc actgtgccca cagctggcct   1091

 gaggcctcgg ggagaagacc agtcccacag gcgtctcctg ggcctgcctc cctgaccgca   1151

 ccccccgcct cctcgcagct gaaatctgag ggctgggtgt gtcgtgacct gtgttttcct   1211

 gggaaggaga ggagtagctc cttccctggg gtgaaactgc cagatgttta tacacaaagt   1271

 tattagactg aagcaggagt gggcagacta gcaggctttc acccaatact taacagcatt   1331

 tctggcccac attccttttt ctgaagtcat tggggccaga tgtgtctccg aattgagaaa   1391

 ttttagattt gagaaagaca acgcgatcca tttatcgtac actttctaac ttcccggcag   1451

 agtgtggaac atctcgccta ccatcaggca cgtgaatatt tctgcagaga aacatgtgac   1511

 tagtcccatt aactgggagc tatacaaact gtaaatagcc tcacctcagt tcagtctaat   1571

 tttgccacta agtaacttag ggaaaaactt accatttgag agcttttagg gtttcagaat   1631

 tgcaagaaca attgtatggg gttgtggacc ttgatctgaa aatcctgctt gcaaacagat   1691

 gtgttagagg gtgaaattgt cggcattaca caaggactcc ttcagttgcc aaaagaccat   1751

 gggcctcttt aaggagcccc tctgtaagtg attgggacag ggctagatcc ctaatggggg   1811

 ctaggggtgg ggagaatcta gcagaagttg tccaggatac tgtggatcaa gtatcaatct   1871

 gaaattaaga gaaattagat actaagagga tggacattta catgtctgtt tcctttcctt   1931

 tcattttcat tctaacatag gaaatgctaa cagatggggc tggcccaaag tcaagcttct   1991

 gactccactt gacacagtgc cattgggcat gtccctcttt gaagggcttg tttgtctatc   2051

 agagactgtc agaactccat gagggcagga gaagggattt tgcaggatga aagtgcttgg   2111

 gaagtagtgg ccaccgttct gggggtttca gcccacctac cccatccacc gggctttcta   2171

 atcacagtcc tgcctgagaa gcgggccctg ctgcccaccc cttatcatgg atcccttagc   2231

 tactgtccgt cttccattgc tgcctggggc tgggctgccg tttttgaaca cctggcagtg   2291

 tctttgtcgc gtcctgtcct ctcttcttac agaccccaac ccaggccttt gccttcttct   2351

 ctcctgtttg gaagcctctg tatcttcaag gtgtgggaac agatttggtt ttctctaaaa   2411

 agctagaacc ttctgctgtg tgcagcaggc atcctccagg ctggtgctgg ctgctctcga   2471

 ggaagctgcg tcagagtgga gctgcccctc tactcagata aaatagcttc agctgcagga   2531

 agccgccccc tcccatgccc accagcccac agcccttcac cccacacagc ccccagagtt   2591

 tgcccgacac cccctgagtg atgacgggtc tcaggggggg gccgccccca cagatgggag   2651

 gcggaggctt gttttccccg cttgggctgg gggcggctgc tgggggggtg aggaggagat   2711

 ggcaatttgt gtcgcatgtt tggtgacaca atccagatgc aggtgggact ttcttgagtg   2771

 gcaggtgtca ccctgggtcc cgtgtgggat ggtttaatac aggggtttgt gtgtttgtgt   2831

 gtgtggaggg ccactgcgcc cccagatcct cctctccccc gagggctgcg tctctaaacc   2891

 tgggaaaaca tcagcctcag gaggaggccc ctttccgggt aactgatgtg tgggagaagc   2951

 caagaggccc ctgcctgtct cctgaatgag gctgtgaggg ttgccatgtg ggcgggaccg   3011

 gttcaaaata gcgcccccgc ccctctaaat tagaccgtgg tctcagcatg atcatcttca   3071

 gtagataagg gacagtggct gatttactcc aaatagttcc agctggccac tcagaccagg   3131

 gccagagtta acttctcaaa caccagccag ctgaaaatta gggttctcgt gcaggcaagt   3191

 gcatggttga cacacagccc tttggtgaca aagctgggct ttgcctgcat agtgcagaca   3251

 aggctgttgg ttcagaggct gcagggcaca ttccaggttg gggccttttg tcggtcggaa   3311

 ttcaatagga cattccctgg ctgtgggtgt ttagggcagg aattacaggc ttgcagagaa   3371

 a                                                                   3372




      <210> 235
      <211> 854
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (410)..(811)

      <400> 235
 cggacgcgtg ggcaagccag gaaggccctg gagattccgg ggtgccccct cctccggcag     60

 agcttgggcc tgggctcacg aggaaggggc tgcagttctc caaggattcc cgcctgctcc    120

 cagacccccg ggagtcgtag gaacccgttc ctggacgctg acgtcggctt tcagggatcc    180

 ctcgccggac gccgcggagg gacagagcct gggaagccgt cgccccgccc cgtccccgcc    240

 cccgcgcgca gtgggcccgg ggcgctgaga cccgcgtaga gcaaagcgca aggtcccagc    300

 gccccttgga tcctcggtgg cagggtccgg gcaagtgtca ttgcgagggt tcaggaagcc    360

 ccggcctgtg atcgtgagcg gaaacccctc ctggagtttc cccaaagcc    atg gac     415
                                                          Met Asp
                                                            1

 agc cct agt ctt cgt gag ctt caa cag cct ctg ctg gag ggc aca gaa      463
 Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly Thr Glu
           5                  10                  15

 tgt gag acc cct gcc cag aag cct ggc agg cat gag ctg ggg tcc ccc      511
 Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly Ser Pro
      20                  25                  30

 tta aga gag ata gcc ttt gcc gag tcc ctg agg ggt ttg cag ttc ctg      559
 Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln Phe Leu
  35                  40                  45                  50

 tca ccg cct ctt ccc tcc gtg agc gct ggc ctg ggg gaa cca agg ccc      607
 Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro Arg Pro
                  55                  60                  65

 cct gat gtt gag gac atg tca tcc agt gac agt gac tcg gac tgg gat      655
 Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp Trp Asp
              70                  75                  80

 gga ggc agc cgt ctt tca cca ttt cta ccc cac gac cac ctc ggc ttg      703
 Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu Gly Leu
          85                  90                  95

 gct gtc ttc tcc atg ctg tgt tgt ttc tgg ccc gtt ggc atc gct gcc      751
 Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile Ala Ala
     100                 105                 110

 ttc tgt cta gcc cag aag acc cgc cct agt tgc ccc tac agc cct cac      799
 Phe Cys Leu Ala Gln Lys Thr Arg Pro Ser Cys Pro Tyr Ser Pro His
 115                 120                 125                 130

 tgt gaa ccc tga ggc cggcagccca gcaaatctgt gggcagagag tggagaatct      854
 Cys Glu Pro 






      <210> 236
      <211> 902
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (154)..(852)

      <400> 236
 gcggggaatt ccatggtatg ggcccaatcc aggtcctcaa agggagggca ggtctgagtc     60

 cttgttctct gaagtcagaa tcctcatctc ccactacaga cctgccaggg cccaggagag    120

 ctcgacccac ccaggcacac catagcccca gag atg gct ggg gac aca gaa gtg     174
                                      Met Ala Gly Asp Thr Glu Val
                                        1               5

 tgg aag caa atg ttt cag gag tta atg cgg gag gtg aag cca tgg cac      222
 Trp Lys Gln Met Phe Gln Glu Leu Met Arg Glu Val Lys Pro Trp His
          10                  15                  20

 agg tgg acc ctg aga cca gac aag ggc ctt ctt ccc aac gtc ctg aag      270
 Arg Trp Thr Leu Arg Pro Asp Lys Gly Leu Leu Pro Asn Val Leu Lys
      25                  30                  35

 cca ggc tgg atg caa tac cag cag tgg acc ttc gcc agg ttc cag tgc      318
 Pro Gly Trp Met Gln Tyr Gln Gln Trp Thr Phe Ala Arg Phe Gln Cys
  40                  45                  50                  55

 tcc tcc tgc tct cgt aac tgg gcc tct gcc caa gtt ctg gtc ctt ttc      366
 Ser Ser Cys Ser Arg Asn Trp Ala Ser Ala Gln Val Leu Val Leu Phe
                  60                  65                  70

 cac atg aac tgg agt gag gag aag tcc agg ggc cag gtg aag atg agg      414
 His Met Asn Trp Ser Glu Glu Lys Ser Arg Gly Gln Val Lys Met Arg
              75                  80                  85

 gtg ttt acc cag aga tgt aag aag tgc ccc caa cct ctg ttt gag gac      462
 Val Phe Thr Gln Arg Cys Lys Lys Cys Pro Gln Pro Leu Phe Glu Asp
          90                  95                 100

 cct gag ttc aca caa gag aac atc tca agg atc ctg aaa aac ctg gtg      510
 Pro Glu Phe Thr Gln Glu Asn Ile Ser Arg Ile Leu Lys Asn Leu Val
     105                 110                 115

 ttc cga att ctg aag aaa tgc tat aga gga aga ttt cag ttg ata gag      558
 Phe Arg Ile Leu Lys Lys Cys Tyr Arg Gly Arg Phe Gln Leu Ile Glu
 120                 125                 130                 135

 gag gtt cct atg atc aag gac atc tct ctt gaa ggg cca cac aat agt      606
 Glu Val Pro Met Ile Lys Asp Ile Ser Leu Glu Gly Pro His Asn Ser
                 140                 145                 150

 gac aac tgt gag gca tgt ctg cag ggc ttc tgt gct ggg ccc ata cag      654
 Asp Asn Cys Glu Ala Cys Leu Gln Gly Phe Cys Ala Gly Pro Ile Gln
             155                 160                 165

 gtt aca agc ctc ccc cca tct cag acc cca aga gta cac tcc att tac      702
 Val Thr Ser Leu Pro Pro Ser Gln Thr Pro Arg Val His Ser Ile Tyr
         170                 175                 180

 aag gtg gag gag gta gtt aag ccc tgg gcc tca gga gag aat gtc tat      750
 Lys Val Glu Glu Val Val Lys Pro Trp Ala Ser Gly Glu Asn Val Tyr
     185                 190                 195

 tcc tac gca tgc caa aac cac atc tgt agg aac tta agc att ttc tgc      798
 Ser Tyr Ala Cys Gln Asn His Ile Cys Arg Asn Leu Ser Ile Phe Cys
 200                 205                 210                 215

 tgt tgt gtc att ctc att gtt atc gtg gtg att gtt gta aaa act gct      846
 Cys Cys Val Ile Leu Ile Val Ile Val Val Ile Val Val Lys Thr Ala
                 220                 225                 230

 ata tga gccttggaaa catgaagcta agtcagtaat aaaatcagat tcaaaaagtc       902
 Ile 






      <210> 237
      <211> 2505
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2505)

      <400> 237
  atg atc att ttc aac ctg agc agt tac aat cca gga ccc ttc att ctg      48
  Met Ile Ile Phe Asn Leu Ser Ser Tyr Asn Pro Gly Pro Phe Ile Leu
    1               5                  10                  15

 gta ggg atc cca ggc ctg gag caa ttc cat gtg tgg att gga att ccc       96
 Val Gly Ile Pro Gly Leu Glu Gln Phe His Val Trp Ile Gly Ile Pro
              20                  25                  30

 ttc tgt atc atc tac att gta gct att gtg gga aac tgc atc ctt ctc      144
 Phe Cys Ile Ile Tyr Ile Val Ala Ile Val Gly Asn Cys Ile Leu Leu
          35                  40                  45

 tac ctc att gtg gtg gag cat agt ctt cat gaa ccc atg ttc ttc ttt      192
 Tyr Leu Ile Val Val Glu His Ser Leu His Glu Pro Met Phe Phe Phe
      50                  55                  60

 ctc tcc atg ctg gcc atg act gac ctc atc ttg tcc aca gct ggt gtg      240
 Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser Thr Ala Gly Val
  65                  70                  75                  80

 cct aaa gca ctc agt atc ttt tgg cta ggg gct cgc gaa atc aca ttc      288
 Pro Lys Ala Leu Ser Ile Phe Trp Leu Gly Ala Arg Glu Ile Thr Phe
                  85                  90                  95

 cca gga tgc ctt aca caa atg ttc ttc ctt cac tat aac ttt gtc ctg      336
 Pro Gly Cys Leu Thr Gln Met Phe Phe Leu His Tyr Asn Phe Val Leu
             100                 105                 110

 gat tca gcc att ctg atg gcc atg gca ttt gat cac tat gta gct atc      384
 Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp His Tyr Val Ala Ile
         115                 120                 125

 tgt tct ccc ttg aga tat acc acc atc ttg act ccc aag acc atc atc      432
 Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Lys Thr Ile Ile
     130                 135                 140

 aag agt gct atg ggc atc tcc ttt cga agc ttc tgc atc atc ctg cca      480
 Lys Ser Ala Met Gly Ile Ser Phe Arg Ser Phe Cys Ile Ile Leu Pro
 145                 150                 155                 160

 gat gta ttc ttg ctg aca tgc ctg cct ttc tgc agg aca cgc atc ata      528
 Asp Val Phe Leu Leu Thr Cys Leu Pro Phe Cys Arg Thr Arg Ile Ile
                 165                 170                 175

 ccc cac aca tac tgt gag cat ata ggt gtt gcc cag ctc gcc tgt gct      576
 Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Gln Leu Ala Cys Ala
             180                 185                 190

 gat atc tcc atc aac ttc tgg tat ggc ttt tgt gtt ccc atc atg acg      624
 Asp Ile Ser Ile Asn Phe Trp Tyr Gly Phe Cys Val Pro Ile Met Thr
         195                 200                 205

 gtc atc tca gat gtg att ctc att gct gtt tcc tac gca cac atc ctc      672
 Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Ala His Ile Leu
     210                 215                 220

 tgt gct gtc ttt ggc ctt ccc tcc caa gat gcc tgc cag aaa gcc ctc      720
 Cys Ala Val Phe Gly Leu Pro Ser Gln Asp Ala Cys Gln Lys Ala Leu
 225                 230                 235                 240

 ggc act tgt ggt tct cat gtc tgt gtc atc ctc atg ttt tat aca cct      768
 Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met Phe Tyr Thr Pro
                 245                 250                 255

 gcc ttt ttc tcc atc ctc gcc cat cgc ttt gga cac aat gtc tct cgc      816
 Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His Asn Val Ser Arg
             260                 265                 270

 acc ttc cac atc atg ttt gcc aat ctc tac att gtt atc cca cct gca      864
 Thr Phe His Ile Met Phe Ala Asn Leu Tyr Ile Val Ile Pro Pro Ala
         275                 280                 285

 ctc aac ccc atg gtt tac gga gtg aag acc aag cag atc aga gat aag      912
 Leu Asn Pro Met Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Lys
     290                 295                 300

 ctg aat ggc gat gtt gag gca gta ggg act gaa gca gga ttg gat gga      960
 Leu Asn Gly Asp Val Glu Ala Val Gly Thr Glu Ala Gly Leu Asp Gly
 305                 310                 315                 320

 tgg aga cgg gat gct cat tcc tcg ttt tta atc tca cct cca aca gca     1008
 Trp Arg Arg Asp Ala His Ser Ser Phe Leu Ile Ser Pro Pro Thr Ala
                 325                 330                 335

 gag agg gac aca gcc aga tgg agg cag gag atg ggg ctg gat cct gca     1056
 Glu Arg Asp Thr Ala Arg Trp Arg Gln Glu Met Gly Leu Asp Pro Ala
             340                 345                 350

 ctg cca gct ttc agt cag aac ttg ctg atc tct ggg tct ggg tcc ttt     1104
 Leu Pro Ala Phe Ser Gln Asn Leu Leu Ile Ser Gly Ser Gly Ser Phe
         355                 360                 365

 gtc ctg ctg ggg atg ccg gga ctg gag gct ctg cat gcc tgg ctc tct     1152
 Val Leu Leu Gly Met Pro Gly Leu Glu Ala Leu His Ala Trp Leu Ser
     370                 375                 380

 gtg cct gtg tgc ctg ctc tac atg gca gct ttg gta ggg aat gcc ctt     1200
 Val Pro Val Cys Leu Leu Tyr Met Ala Ala Leu Val Gly Asn Ala Leu
 385                 390                 395                 400

 cta gtg ggg ctg gtg gtc gct gac aag gca ctc tgg gca ccc atg tac     1248
 Leu Val Gly Leu Val Val Ala Asp Lys Ala Leu Trp Ala Pro Met Tyr
                 405                 410                 415

 cag ctg ctg tgg ctt ctg gca gct gct gat ttt gtt ctg gcc aca tcc     1296
 Gln Leu Leu Trp Leu Leu Ala Ala Ala Asp Phe Val Leu Ala Thr Ser
             420                 425                 430

 aca gtg ccc aaa gct ctg gct gta ctt tgg ggc ttg tct atg ctg ctg     1344
 Thr Val Pro Lys Ala Leu Ala Val Leu Trp Gly Leu Ser Met Leu Leu
         435                 440                 445

 tcc acg gcc gta gac tgc cag cct ttg cgc tat ggg gcg ttg ctg gcc     1392
 Ser Thr Ala Val Asp Cys Gln Pro Leu Arg Tyr Gly Ala Leu Leu Ala
     450                 455                 460

 cag ttt gtg aaa ctg cct tac tgt gga cag tgg gcc ctg ccc cac acc     1440
 Gln Phe Val Lys Leu Pro Tyr Cys Gly Gln Trp Ala Leu Pro His Thr
 465                 470                 475                 480

 tac tgc gaa cac atg ggt gtg gct tgc ctg gca tgt gga gat acg tgc     1488
 Tyr Cys Glu His Met Gly Val Ala Cys Leu Ala Cys Gly Asp Thr Cys
                 485                 490                 495

 ccc atc atc agg tat gga ctg gcc acc aca ctg ctc tcc cca gcc ctg     1536
 Pro Ile Ile Arg Tyr Gly Leu Ala Thr Thr Leu Leu Ser Pro Ala Leu
             500                 505                 510

 gac cta ggg ctc ata ggt gct tcc tat gcc ctc att ttc cgt gct gtc     1584
 Asp Leu Gly Leu Ile Gly Ala Ser Tyr Ala Leu Ile Phe Arg Ala Val
         515                 520                 525

 tgc cgt ctg cca tcc cat gtt gcc tgc cac aag gct ctg ggt aac tgc     1632
 Cys Arg Leu Pro Ser His Val Ala Cys His Lys Ala Leu Gly Asn Cys
     530                 535                 540

 ggg acc tat gct agc atc att ggt ctc ttc tac aca cct gcc ctc ttc     1680
 Gly Thr Tyr Ala Ser Ile Ile Gly Leu Phe Tyr Thr Pro Ala Leu Phe
 545                 550                 555                 560

 tcc ttc ctt gct cac tgt ttt ggg tgt cac aca gtg ccc aac cat att     1728
 Ser Phe Leu Ala His Cys Phe Gly Cys His Thr Val Pro Asn His Ile
                 565                 570                 575

 cac atc cta ctg gct aac ctc tac gca gtg gtg ttc cca gct ttc aat     1776
 His Ile Leu Leu Ala Asn Leu Tyr Ala Val Val Phe Pro Ala Phe Asn
             580                 585                 590

 cct gtg gtc tat gga gtg cag act cag cag agc tca gag gct cag gaa     1824
 Pro Val Val Tyr Gly Val Gln Thr Gln Gln Ser Ser Glu Ala Gln Glu
         595                 600                 605

 ctt gct tca act ttt ctg ggc agg agc agt gaa gaa ggg ata acg gca     1872
 Leu Ala Ser Thr Phe Leu Gly Arg Ser Ser Glu Glu Gly Ile Thr Ala
     610                 615                 620

 gtt cag agg cca gaa gac ttg agg ctc cac agc atc atg tgg cag ggc     1920
 Val Gln Arg Pro Glu Asp Leu Arg Leu His Ser Ile Met Trp Gln Gly
 625                 630                 635                 640

 ctt gaa gaa aaa tca gct tcc agt aat gtg aac tgc agc cag atc cag     1968
 Leu Glu Glu Lys Ser Ala Ser Ser Asn Val Asn Cys Ser Gln Ile Gln
                 645                 650                 655

 cca gtg cat gag gta ggt cca ggg tgc tcc aac atg ctt cat tat gtt     2016
 Pro Val His Glu Val Gly Pro Gly Cys Ser Asn Met Leu His Tyr Val
             660                 665                 670

 tac tgt gcc tgt ggc cat ggt ttg cag ctg gtg aga agt gtg tca agc     2064
 Tyr Cys Ala Cys Gly His Gly Leu Gln Leu Val Arg Ser Val Ser Ser
         675                 680                 685

 tct gtg gat gaa gga ggc aca tgc cat tgt atg gtt cac cta ccc aac     2112
 Ser Val Asp Glu Gly Gly Thr Cys His Cys Met Val His Leu Pro Asn
     690                 695                 700

 aac ccc atc ccc ctg gag cag ctg gaa cag cta caa agt aca gct cag     2160
 Asn Pro Ile Pro Leu Glu Gln Leu Glu Gln Leu Gln Ser Thr Ala Gln
 705                 710                 715                 720

 gag ctc att tgc aag tat gag cag aag ctg tct aga caa ctt cct gtt     2208
 Glu Leu Ile Cys Lys Tyr Glu Gln Lys Leu Ser Arg Gln Leu Pro Val
                 725                 730                 735

 cat ccc ctg cat gct gat gtc agt gag tgt gca cgc gcc att gaa gat     2256
 His Pro Leu His Ala Asp Val Ser Glu Cys Ala Arg Ala Ile Glu Asp
             740                 745                 750

 aaa gac aat gag gtt ctg gaa atg agt cac atg ctg aag tcc tgg aat     2304
 Lys Asp Asn Glu Val Leu Glu Met Ser His Met Leu Lys Ser Trp Asn
         755                 760                 765

 ccc agt gcc ctt gct tct ccc tat gag aac cca ggc ttc aac ctg ctg     2352
 Pro Ser Ala Leu Ala Ser Pro Tyr Glu Asn Pro Gly Phe Asn Leu Leu
     770                 775                 780

 tgc ctg gag ctg gag gga gca cag gag ttg gtg act caa ctt aaa gcc     2400
 Cys Leu Glu Leu Glu Gly Ala Gln Glu Leu Val Thr Gln Leu Lys Ala
 785                 790                 795                 800

 atg gga ggt gtt agt gtg gct ggg gac ctc ctc cac caa ctt cag agc     2448
 Met Gly Gly Val Ser Val Ala Gly Asp Leu Leu His Gln Leu Gln Ser
                 805                 810                 815

 cag aac aca cca agc gcc caa ctt acc ctt aaa gct gcc aca gta gct     2496
 Gln Asn Thr Pro Ser Ala Gln Leu Thr Leu Lys Ala Ala Thr Val Ala
             820                 825                 830

 gtt tcc taa                                                         2505
 Val Ser 






      <210> 238
      <211> 3812
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (778)..(2814)

      <400> 238
 atgtctgcct actacaggaa taactggtct gaggaagacc cagattaccc tgactattca     60

 gggtctcaga accgtacgca ggggtatttg aaaactcaag gttatccaga tgttccaggt    120

 cctctgaaca atccagacta ccccggcacc aggagcaatc catactctgt agcctccaga    180

 acacgtccag actatcctgg gtctctggca gaaccaaatt atcctagatc tctgagtaat    240

 ccagactatt ctggcaccag aagcaatgca tactctgcag cctctagaac aagcccagac    300

 catcctacct ctctaccaga gccagattat agtgaatttc agagtcatcc ctaccaccga    360

 gcatcatcca gacaaccaga ctaccctgga tctcaacgaa atcctgattt tgcaggctcc    420

 agcagcagtg gaaactatgc aggctccaga acacatccag atcattttgg ctccttagaa    480

 ccggactacc ctggagctca gagcaactct gatcatcctg gacccagagc caatttgaac    540

 catccaggat ccagaaagaa tctggaacat acaagtttta gaatcaatcc atacgcagac    600

 tctctgggaa agcctgatta tccaggcgct gacattcaac ctaactctcc accctttttt    660

 ggggagccag actatcccag tgctgaggac aatcagaact tgccaagcac ttggagagaa    720

 cctgattatt cagatgctga gaatggtcat gattatggct cttctgagac cccaaag       777                                                                 
 atg acc agg ggg gtg ctc agc aga aca tct tca atc cag ccc tca ttt      825
 Met Thr Arg Gly Val Leu Ser Arg Thr Ser Ser Ile Gln Pro Ser Phe
   1               5                  10                  15

 cgt cac agg agt gat gac ccc gtg ggc agt ctt tgg gga gag aat gat      873
 Arg His Arg Ser Asp Asp Pro Val Gly Ser Leu Trp Gly Glu Asn Asp
              20                  25                  30

 tac cct gaa ggc att gaa atg gca tcc atg gag atg gca aac tca tat      921
 Tyr Pro Glu Gly Ile Glu Met Ala Ser Met Glu Met Ala Asn Ser Tyr
          35                  40                  45

 ggc cac tct ctg cca ggt gct cct gga agt ggc tat gtg aac cct gct      969
 Gly His Ser Leu Pro Gly Ala Pro Gly Ser Gly Tyr Val Asn Pro Ala
      50                  55                  60

 tat gta ggt gaa agt ggt cct gtc cat gct tat gga aac cca cca ttg     1017
 Tyr Val Gly Glu Ser Gly Pro Val His Ala Tyr Gly Asn Pro Pro Leu
  65                  70                  75                  80

 tct gaa tgt gat tgg cac aag tca ccc caa gga cag aag tta atc gca     1065
 Ser Glu Cys Asp Trp His Lys Ser Pro Gln Gly Gln Lys Leu Ile Ala
                  85                  90                  95

 tcc ctt ata ccc atg aca tcc aga gac aga att aaa gcc atc agg aac     1113
 Ser Leu Ile Pro Met Thr Ser Arg Asp Arg Ile Lys Ala Ile Arg Asn
             100                 105                 110

 cag cca agg acc atg gaa gag aaa agg aag ctt agg aaa ata gtt gac     1161
 Gln Pro Arg Thr Met Glu Glu Lys Arg Lys Leu Arg Lys Ile Val Asp
         115                 120                 125

 aaa gaa aaa agc aaa cag acc cat cgt atc ctt cag ctc aat tgc tgt     1209
 Lys Glu Lys Ser Lys Gln Thr His Arg Ile Leu Gln Leu Asn Cys Cys
     130                 135                 140

 att cag tgt ctg aac tcc att tcc cgg gct tat cgg aga tcc aag aac     1257
 Ile Gln Cys Leu Asn Ser Ile Ser Arg Ala Tyr Arg Arg Ser Lys Asn
 145                 150                 155                 160

 agc ctg tcg gaa att ctg aat tcc atc agc ctg tgg cag aag acg ctg     1305
 Ser Leu Ser Glu Ile Leu Asn Ser Ile Ser Leu Trp Gln Lys Thr Leu
                 165                 170                 175

 aag atc att gga ggc aag ttt gga acc agc gtc ctc tcc tat ttc aac     1353
 Lys Ile Ile Gly Gly Lys Phe Gly Thr Ser Val Leu Ser Tyr Phe Asn
             180                 185                 190

 ttt ctg aga tgg ctt ttg aag ttc aac att ttc tca ttc atc ctg aac     1401
 Phe Leu Arg Trp Leu Leu Lys Phe Asn Ile Phe Ser Phe Ile Leu Asn
         195                 200                 205

 ttc agc ttc atc ata atc cct cag ttt acc gtg gcc aaa aag aac acc     1449
 Phe Ser Phe Ile Ile Ile Pro Gln Phe Thr Val Ala Lys Lys Asn Thr
     210                 215                 220

 ctc cag ttc act ggg ctg gag ttt ttc act ggg gtg ggt tat ttt agg     1497
 Leu Gln Phe Thr Gly Leu Glu Phe Phe Thr Gly Val Gly Tyr Phe Arg
 225                 230                 235                 240

 gac aca gtg atg tac tat ggc ttt tac acc aat tcc acc atc cag cac     1545
 Asp Thr Val Met Tyr Tyr Gly Phe Tyr Thr Asn Ser Thr Ile Gln His
                 245                 250                 255

 ggg aac agc ggg gca tcc tac aac atg cag ctg gcc tac atc ttc aca     1593
 Gly Asn Ser Gly Ala Ser Tyr Asn Met Gln Leu Ala Tyr Ile Phe Thr
             260                 265                 270

 atc gga gca tgc ttg acc acc tgc ttc ttc agt ttg ctg ttc agc atg     1641
 Ile Gly Ala Cys Leu Thr Thr Cys Phe Phe Ser Leu Leu Phe Ser Met
         275                 280                 285

 gcc aag tat ttc cgg aac aac ttc att aat ccc cac att tac tcc gga     1689
 Ala Lys Tyr Phe Arg Asn Asn Phe Ile Asn Pro His Ile Tyr Ser Gly
     290                 295                 300

 ggg atc acc aag ctg atc ttt tgc tgg gac ttc act gtc act cat gaa     1737
 Gly Ile Thr Lys Leu Ile Phe Cys Trp Asp Phe Thr Val Thr His Glu
 305                 310                 315                 320

 aaa gct gtg aag cta aaa cag aag aat ctt agc act gag ata agg gag     1785
 Lys Ala Val Lys Leu Lys Gln Lys Asn Leu Ser Thr Glu Ile Arg Glu
                 325                 330                 335

 aac ctg tca gag ctc cgt cag gag aat tcc aag ttg acg ttc aat cag     1833
 Asn Leu Ser Glu Leu Arg Gln Glu Asn Ser Lys Leu Thr Phe Asn Gln
             340                 345                 350

 ctg ctg acc cgc ttc tct gcc tac atg gta gcc tgg gtt gtc tct aca     1881
 Leu Leu Thr Arg Phe Ser Ala Tyr Met Val Ala Trp Val Val Ser Thr
         355                 360                 365

 gga gtg gcc ata gcc tgc tgt gca gcc gtt tat tac ctg gct gag tac     1929
 Gly Val Ala Ile Ala Cys Cys Ala Ala Val Tyr Tyr Leu Ala Glu Tyr
     370                 375                 380

 aac tta gag ttc ctg aag aca cac agt aac cct ggg gcg gtg ctg tta     1977
 Asn Leu Glu Phe Leu Lys Thr His Ser Asn Pro Gly Ala Val Leu Leu
 385                 390                 395                 400

 ctg cct ttc gtt gtg tcc tgc att aat ctg gcc gtg cca tgc atc tac     2025
 Leu Pro Phe Val Val Ser Cys Ile Asn Leu Ala Val Pro Cys Ile Tyr
                 405                 410                 415

 tcc atg ttc agg ctt gtg gag agg tac gag atg cca cgg cac gaa gtc     2073
 Ser Met Phe Arg Leu Val Glu Arg Tyr Glu Met Pro Arg His Glu Val
             420                 425                 430

 tac gtt ctc ctg atc cga aac atc ttt ttg aaa ata tca atc att ggc     2121
 Tyr Val Leu Leu Ile Arg Asn Ile Phe Leu Lys Ile Ser Ile Ile Gly
         435                 440                 445

 att ctt tgt tac tat tgg ctc aac acc gtg gcc ctg tct ggt gaa gag     2169
 Ile Leu Cys Tyr Tyr Trp Leu Asn Thr Val Ala Leu Ser Gly Glu Glu
     450                 455                 460

 tgt tgg gaa acc ctc att ggc cag gac atc tac cgg ctc ctt ctg atg     2217
 Cys Trp Glu Thr Leu Ile Gly Gln Asp Ile Tyr Arg Leu Leu Leu Met
 465                 470                 475                 480

 gat ttt gtg ttc tct tta gtc aat tcc ttc ctg ggg gag ttt ctg agg     2265
 Asp Phe Val Phe Ser Leu Val Asn Ser Phe Leu Gly Glu Phe Leu Arg
                 485                 490                 495

 aga atc att ggg atg caa ctg atc aca agt ctt ggc ctt cag gag ttt     2313
 Arg Ile Ile Gly Met Gln Leu Ile Thr Ser Leu Gly Leu Gln Glu Phe
             500                 505                 510

 gac att gcc agg aac gtt cta gaa ctg atc tat gca caa act ctg gtg     2361
 Asp Ile Ala Arg Asn Val Leu Glu Leu Ile Tyr Ala Gln Thr Leu Val
         515                 520                 525

 tgg att ggc atc ttc ttc tgc ccc ctg ctg ccc ttt atc caa atg att     2409
 Trp Ile Gly Ile Phe Phe Cys Pro Leu Leu Pro Phe Ile Gln Met Ile
     530                 535                 540

 atg ctt ttc atc atg ttc tac tcc aaa aat atc agc ctg atg atg aat     2457
 Met Leu Phe Ile Met Phe Tyr Ser Lys Asn Ile Ser Leu Met Met Asn
 545                 550                 555                 560

 ttc cag cct ccg agc aaa gcc tgg cgg gcc tca cag atg atg act ttc     2505
 Phe Gln Pro Pro Ser Lys Ala Trp Arg Ala Ser Gln Met Met Thr Phe
                 565                 570                 575

 ttc atc ttc ttg ctc ttt ttc cca tcc ttc acc ggg gtc ttg tgc acc     2553
 Phe Ile Phe Leu Leu Phe Phe Pro Ser Phe Thr Gly Val Leu Cys Thr
             580                 585                 590

 ctg gcc atc acc atc tgg aga ttg aag cct tca gct gac tgt ggc cct     2601
 Leu Ala Ile Thr Ile Trp Arg Leu Lys Pro Ser Ala Asp Cys Gly Pro
         595                 600                 605

 ttt cga ggt ctg cct ctc ttc att cac tcc atc tac agc tgg atc gac     2649
 Phe Arg Gly Leu Pro Leu Phe Ile His Ser Ile Tyr Ser Trp Ile Asp
     610                 615                 620

 acc cta agt aca cgg cct ggg cta cct gtg ggt tgt ttg gat cta tcg     2697
 Thr Leu Ser Thr Arg Pro Gly Leu Pro Val Gly Cys Leu Asp Leu Ser
 625                 630                 635                 640

 gaa cct cat tgg aag tgt gca ctt ctt ttt cat cct cac cct cat tgt     2745
 Glu Pro His Trp Lys Cys Ala Leu Leu Phe His Pro His Pro His Cys
                 645                 650                 655

 gct aat cat cac cta tct tta ctg gca gat cac aga ggg aag gaa gat     2793
 Ala Asn His His Leu Ser Leu Leu Ala Asp His Arg Gly Lys Glu Asp
             660                 665                 670

 tat gat aag gct gct cca tga gc agatcattaa tgagggcaaa gataaaatgt     2846
 Tyr Asp Lys Ala Ala Pro 
         675

 tcctgataga aaaattgatc aagctgcagg atatggagaa gaaagcaaac cccagctcac   2906

 ttgttctgga aaggagagag gtggagcaac aaggcttttt gcatttgggg gaacatgatg   2966

 gcagtcttga cttgcgatct agaagatcag ttcaagaagg taatccaagg gcctgatgac   3026

 tcttttggta accagacacc aatcaaataa ggggaggaga cgaaaatgga atgatttctt   3086

 ccatgccacc tgtgccttta ggaactgccc agaagaaaat ccaaggcttt agccaggagc   3146

 ggaaactgac taccatgtaa ttatcaaagt aaaattgggc attccatgct atttttaata   3206

 cctggattgc tgatttttca agacaaaata cttggggttt tccaataaag attgttgtaa   3266

 tattgaaatg agcctacaaa aacctaggaa gagataacta gggaataatg tatattatct   3326

 tcaagaagtg tgtgcaggaa tgattggttc ttagaaatct ctcctgccag acttcccaga   3386

 cctggcaaag gtttagaaac tgttgctaag aaaagtggtc catcctgaat aaacatgtaa   3446

 tactccagca gggatatgaa gcctctgaat tgtagaacct gcatttattt gtgactttga   3506

 actaaagaca tcccccatgt cccaaaggtg gaatacaacc agaggtctca tctctgaact   3566

 ttcttgcgta ctgattacat gagtctttgg agtcggggat ggaggaggtt ctgcccctgt   3626

 gaggtgttat acatgaccat caaagtccta cgtcaagcta gctttgcagt ggcagtaccg   3686

 tagccaatga gatttatccg agacgcgatt attgctaatt ggaaattttc ccaatacccc   3746

 accgtgatga cttgaaatat aatcagcgct ggcaattttt gacagtctct acggagactg   3806

 aataag                                                              3812




      <210> 239
      <211> 980
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (61)..(930)

      <400> 239
 gctgactcga gtccccgccg cgcttgtcgt cgccgccgcc gggatccgca gccccgcgcc     60
                                                                 
 atg gag ccg gcc gcg ggc atc cag cgc cgc agc tcc cag ggg ccc acc      108
 Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr
   1               5                  10                  15

 gtc ccg ccg ccg ccc cgg ggc cac gcg cca ccg gct gcc gcc ccc ggc      156
 Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly
              20                  25                  30

 ccg gcc ccg ctg agc tcc ccg gtg cgc gag ccg ccc cag ctg gag gag      204
 Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu
          35                  40                  45

 gag cgg cag gtg cgg atc agc gag agc ggc cag ttc agc gac ggg ctg      252
 Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu
      50                  55                  60

 gag gac cga ggc tta cta gaa agc agc acc cgc ctg aaa cct cac gaa      300
 Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu
  65                  70                  75                  80

 gcc cag aac tac agg aag aag gca ttg tgg gtg tcc tgg ttc tcc atc      348
 Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile
                  85                  90                  95

 att gtc acc ctg gcc ctc gcg gtg gct gcc ttt act gtc tcc gtt atg      396
 Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met
             100                 105                 110

 agg tac agc gcc tct gct ttt ggg ttt gca ttt gat gcc atc ctg gac      444
 Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp
         115                 120                 125

 gtc ctg tca tcg gcg att gtc ctg tgg cgt tac agc aac gcg gcc gct      492
 Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala
     130                 135                 140

 gtg cac tct gcc cat agg gag tac ata gcc tgt gtc atc ttg ggg gtg      540
 Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val
 145                 150                 155                 160

 ata ttc ctt ctg tca tcc ata tgt ata gtg gtc aaa gcc atc cat gac      588
 Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp
                 165                 170                 175

 ctc tca act agg ctg ctc cca gaa gtg gac gat ttc ctg ttc agt gtc      636
 Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val
             180                 185                 190

 tcc att tta agt ggg att ctt tgc agc atc ctg gcc gtg ttg aag ttc      684
 Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe
         195                 200                 205

 atg ctg ggg aag gtt ctg acc agt aga gca ctc ata aca gat ggg ttt      732
 Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe
     210                 215                 220

 aac tcc ctc gtg ggt ggc gtg atg ggc ttc tcc att ctt ctg agc gcg      780
 Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala
 225                 230                 235                 240

 gaa gtg ttc aag cat gac tcg gcg gtc tgg tac ctg gac ggc agc ata      828
 Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile
                 245                 250                 255

 ggc gtt ctg atc ggc ctc acc ata ttt gcc tat ggg gtc aaa ctc ctc      876
 Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu
             260                 265                 270

 atc gac atg gtg ccg agg gtg agg cag aca cgt cac tac gag atg ttt      924
 Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe
         275                 280                 285

 gag tga agggggccag catccgcatg agaccatcga gatgaggagt ttccacatag       980
 Glu 






      <210> 240
      <211> 2964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2472)

      <400> 240
  atg gct ttg cgc cgc gct gtg cgc ttc ccg gag ggc cgc ggc gcc ccc      48
  Met Ala Leu Arg Arg Ala Val Arg Phe Pro Glu Gly Arg Gly Ala Pro
    1               5                  10                  15

 cag ccc ggc ccg ggg ccc acc gcc tgc ccg gcc ccc tgc cac tgc cag       96
 Gln Pro Gly Pro Gly Pro Thr Ala Cys Pro Ala Pro Cys His Cys Gln
              20                  25                  30

 gag gac ggc atc atg ctg tct gcc gac tgc tct gag ctc ggg ctg tcc      144
 Glu Asp Gly Ile Met Leu Ser Ala Asp Cys Ser Glu Leu Gly Leu Ser
          35                  40                  45

 gcc gtt ccg ggg gac ctg gac ccc ctg acg gct tac ctg ttg gga tgt      192
 Ala Val Pro Gly Asp Leu Asp Pro Leu Thr Ala Tyr Leu Leu Gly Cys
      50                  55                  60

 ccc cct cca ctc caa aag gca cag gct gtg ggc cag aca tgg gag aac      240
 Pro Pro Pro Leu Gln Lys Ala Gln Ala Val Gly Gln Thr Trp Glu Asn
  65                  70                  75                  80

 agg tcc cag gag gag aaa aac acc cga gag gcc aaa ctt ggg caa gac      288
 Arg Ser Gln Glu Glu Lys Asn Thr Arg Glu Ala Lys Leu Gly Gln Asp
                  85                  90                  95

 ctg aat tat aac aag ctg cag gag ttc cct gtg gcc atc cgg acc ctg      336
 Leu Asn Tyr Asn Lys Leu Gln Glu Phe Pro Val Ala Ile Arg Thr Leu
             100                 105                 110

 ggc aga ctg cag gaa ctg ggg ttc cat aac aac aac atc aag gcc atc      384
 Gly Arg Leu Gln Glu Leu Gly Phe His Asn Asn Asn Ile Lys Ala Ile
         115                 120                 125

 cca gaa aag gcc ttc atg ggg aac cct ctg cta cag acg ata cac ttt      432
 Pro Glu Lys Ala Phe Met Gly Asn Pro Leu Leu Gln Thr Ile His Phe
     130                 135                 140

 tat gat aac cca atc cag ttt gtg gga aga tcg gca ttc cag tac ctg      480
 Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln Tyr Leu
 145                 150                 155                 160

 cct aaa ctc cac aca cta tct ctg aat ggt gcc atg gac atc cag gag      528
 Pro Lys Leu His Thr Leu Ser Leu Asn Gly Ala Met Asp Ile Gln Glu
                 165                 170                 175

 ttt cca gat ctc aaa ggc acc acc agc ctg gag atc ctg acc ctg acc      576
 Phe Pro Asp Leu Lys Gly Thr Thr Ser Leu Glu Ile Leu Thr Leu Thr
             180                 185                 190

 cgc gca ggc atc cgg ctg ctc cca tcg ggg atg tgc caa cag ctg ccc      624
 Arg Ala Gly Ile Arg Leu Leu Pro Ser Gly Met Cys Gln Gln Leu Pro
         195                 200                 205

 agg ctc cga gtc ctg gaa ctg tct cac aat caa att gag gag ctg ccc      672
 Arg Leu Arg Val Leu Glu Leu Ser His Asn Gln Ile Glu Glu Leu Pro
     210                 215                 220

 agc ctg cac agg tgt cag aaa ttg gag gaa atc ggc ctc caa cac aac      720
 Ser Leu His Arg Cys Gln Lys Leu Glu Glu Ile Gly Leu Gln His Asn
 225                 230                 235                 240

 cgc atc tgg gaa att gga gct gac acc ttc agc cag ctg agc tcc ctg      768
 Arg Ile Trp Glu Ile Gly Ala Asp Thr Phe Ser Gln Leu Ser Ser Leu
                 245                 250                 255

 caa gcc ctg gat ctt agc tgg aac gcc atc cgg tcc atc cac cct gag      816
 Gln Ala Leu Asp Leu Ser Trp Asn Ala Ile Arg Ser Ile His Pro Glu
             260                 265                 270

 gcc ttc tcc acc ctg cac tcc ctg gtc aag ctg gac ctg aca gac aac      864
 Ala Phe Ser Thr Leu His Ser Leu Val Lys Leu Asp Leu Thr Asp Asn
         275                 280                 285

 cag ctg acc aca ctg ccc ctg gct gga ctt ggg ggc ttg atg cat ctg      912
 Gln Leu Thr Thr Leu Pro Leu Ala Gly Leu Gly Gly Leu Met His Leu
     290                 295                 300

 aag ctc aaa ggg aac ctt gct ctc tcc cag gcc ttc tcc aag gac agt      960
 Lys Leu Lys Gly Asn Leu Ala Leu Ser Gln Ala Phe Ser Lys Asp Ser
 305                 310                 315                 320

 ttc cca aaa ctg agg atc ctg gag gtg cct tat gcc tac cag tgc tgt     1008
 Phe Pro Lys Leu Arg Ile Leu Glu Val Pro Tyr Ala Tyr Gln Cys Cys
                 325                 330                 335

 ccc tat ggg atg tgt gcc agc ttc ttc aag gcc tct ggg cag tgg gag     1056
 Pro Tyr Gly Met Cys Ala Ser Phe Phe Lys Ala Ser Gly Gln Trp Glu
             340                 345                 350

 gct gaa gac ctt cac ctt gat gat gag gag tct tca aaa agg ccc ctg     1104
 Ala Glu Asp Leu His Leu Asp Asp Glu Glu Ser Ser Lys Arg Pro Leu
         355                 360                 365

 ggc ctc ctt gcc aga caa gca gag aac cac tat gac cag gac ctg gat     1152
 Gly Leu Leu Ala Arg Gln Ala Glu Asn His Tyr Asp Gln Asp Leu Asp
     370                 375                 380

 gag ctc cag ctg gag atg gag gac tca aag cca cac ccc agt gtc cag     1200
 Glu Leu Gln Leu Glu Met Glu Asp Ser Lys Pro His Pro Ser Val Gln
 385                 390                 395                 400

 tgt agc cct act cca ggc ccc ttc aag ccc tgt gag tac ctc ttt gaa     1248
 Cys Ser Pro Thr Pro Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu
                 405                 410                 415

 agc tgg ggc atc cgc ctg gcc gtg tgg gcc atc gtg ttg ctc tcc gtg     1296
 Ser Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val
             420                 425                 430

 ctc tgc aat gga ctg gtg ctg ctg acc gtg ttc gct ggc ggg cct gtc     1344
 Leu Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val
         435                 440                 445

 ccc ctg ccc ccg gtc aag ttt gtg gta ggt gcg att gca ggc gcc aac     1392
 Pro Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn
     450                 455                 460

 acc ttg act ggc att tcc tgt ggc ctt cta gcc tca gtc gat gcc ctg     1440
 Thr Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu
 465                 470                 475                 480

 acc ttt ggt cag ttc tct gag tac gga gcc cgc tgg gag acg ggg cta     1488
 Thr Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu
                 485                 490                 495

 ggc tgc cgg gcc act ggc ttc ctg gca gta ctt ggg tcg gag gca tcg     1536
 Gly Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser
             500                 505                 510

 gtg ctg ctg ctc act ctg gcc gca gtg cag tgc agc gtc tcc gtc tcc     1584
 Val Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser
         515                 520                 525

 tgt gtc cgg gcc tat ggg aag tcc ccc tcc ctg ggc agc gtt cga gca     1632
 Cys Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala
     530                 535                 540

 ggg gtc cta ggc tgc ctg gca ctg gca ggg ctg gcc gcc gca ctg ccc     1680
 Gly Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro
 545                 550                 555                 560

 ctg gcc tca gtg gga gaa tac ggg gcc tcc cca ctc tgc ctg ccc tac     1728
 Leu Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr
                 565                 570                 575

 gcg cca cct gag ggt cag cca gca gcc ctg ggc ttc acc gtg gcc ctg     1776
 Ala Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu
             580                 585                 590

 gtg atg atg aac tcc ttc tgt ttc ctg gtc gtg gcc ggt gcc tac atc     1824
 Val Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile
         595                 600                 605

 aaa ctg tac tgt gac ctg ccg cgg ggc gac ttt gag gcc gtg tgg gac     1872
 Lys Leu Tyr Cys Asp Leu Pro Arg Gly Asp Phe Glu Ala Val Trp Asp
     610                 615                 620

 tgc gcc atg gtg agg cac gtg gcc tgg ctc atc ttc gca gac ggg ctc     1920
 Cys Ala Met Val Arg His Val Ala Trp Leu Ile Phe Ala Asp Gly Leu
 625                 630                 635                 640

 ctc tac tgt ccc gtg gcc ttc ctc agc ttc gcc tcc atg ctg ggc ctc     1968
 Leu Tyr Cys Pro Val Ala Phe Leu Ser Phe Ala Ser Met Leu Gly Leu
                 645                 650                 655

 ttc cct gtc acg ccc gag gcc gtc aag tct gtc ctg ctg gtg gtg ctg     2016
 Phe Pro Val Thr Pro Glu Ala Val Lys Ser Val Leu Leu Val Val Leu
             660                 665                 670

 ccc ctg cct gcc tgc ctc aac cca ctg ctg tac ctg ctc ttc aac ccc     2064
 Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu Tyr Leu Leu Phe Asn Pro
         675                 680                 685

 cac ttc cgg gat gac ctt cgg cgg ctt cgg ccc cgc gca ggg gac tca     2112
 His Phe Arg Asp Asp Leu Arg Arg Leu Arg Pro Arg Ala Gly Asp Ser
     690                 695                 700

 ggg ccc cta gcc tat gct gcg gcc ggg gag ctg gag aag agc tcc tgt     2160
 Gly Pro Leu Ala Tyr Ala Ala Ala Gly Glu Leu Glu Lys Ser Ser Cys
 705                 710                 715                 720

 gat tct acc cag gcc ctg gta gcc ttc tct gat gtg gat ctc att ctg     2208
 Asp Ser Thr Gln Ala Leu Val Ala Phe Ser Asp Val Asp Leu Ile Leu
                 725                 730                 735

 gaa gct tct gaa gct ggg cgg ccc cct ggg ctg gag acc tat ggc ttc     2256
 Glu Ala Ser Glu Ala Gly Arg Pro Pro Gly Leu Glu Thr Tyr Gly Phe
             740                 745                 750

 ccc tca gtg acc ctc atc tcc tgt cag cag cca ggg gcc ccc agg ctg     2304
 Pro Ser Val Thr Leu Ile Ser Cys Gln Gln Pro Gly Ala Pro Arg Leu
         755                 760                 765

 gag ggc agc cat tgt gta gag cca gag ggg aac cac ttt ggg aac ccc     2352
 Glu Gly Ser His Cys Val Glu Pro Glu Gly Asn His Phe Gly Asn Pro
     770                 775                 780

 caa ccc tcc atg gat gga gaa ctg ctg ctg agg gca gag gga tct acg     2400
 Gln Pro Ser Met Asp Gly Glu Leu Leu Leu Arg Ala Glu Gly Ser Thr
 785                 790                 795                 800

 cca gca ggt gga ggc ttg tca ggg ggt ggc ggc ttt cag ccc tct ggc     2448
 Pro Ala Gly Gly Gly Leu Ser Gly Gly Gly Gly Phe Gln Pro Ser Gly
                 805                 810                 815

 ttg gcc ttt gct tca cac gtg taa atatccctcc ccattcttct cttcccctct    2502
 Leu Ala Phe Ala Ser His Val 
             820

 cttccctttc ctctctcccc ctcggtgaat gatggctgct tctaaaacaa atacaaccaa   2562

 aactcagcag tgtgatctat agcaggatgg cccagtccct ggctccactg atcacctctc   2622

 tcctgtgacc atcaccaacg ggtgcctctt ggcctggctt tcccttggcc ttcctcagct   2682

 tcaccttgat actgggcctc ttccttgtca tgtctgaagc tgtggaccag agacctggac   2742

 ttttgtctgc ttaagggaaa tgagggaagt aaagacagtg aaggggtgga gggttgatca   2802

 gggcacagtg gacagggaga cctcacagag aaaggcctgg aaggtgattt cccgtgtgac   2862

 tcatggatag gatacaaaat gtgttccatg taccattaat cttgacatat gccatgcata   2922

 aagacttcct attaaaataa gctttggaag agaaaaaaaa aa                      2964




      <210> 241
      <211> 978
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (362)..(646)

      <400> 241
 ctctctctct gcagatgtta tttttgctac atttgctatt ttaacctgtc agttaaaaaa     60

 taattactat gtcagtatgg ctggcagctc atataggaaa aatatgctgt ctcttaatca    120

 aaggtgatta cagttttccc ctgtctataa atgtgcttgt tgtgtaacga gaatgcatta    180

 gtctcagcct gatgtacgaa atgaaaggca gtaagaagca gcaccattgt tatcactcca    240

 ggcgtgtcta atgaatcgtg tttccatgtt ctctcggtca cgccgtagag tgccctcagc    300

 cagggctaag cctcctgtaa aatgctcttt aagattattg tagcaagaac agaaatgctg    360

 c    atg gct ggg ggt ggg gag aga atg cca acg aga cag ctg cat ttc     406
      Met Ala Gly Gly Gly Glu Arg Met Pro Thr Arg Gln Leu His Phe
        1               5                  10                  15

 aaa cag tta cag ctg caa gga tta ctc ata gta ata gca gtg aca gac      454
 Lys Gln Leu Gln Leu Gln Gly Leu Leu Ile Val Ile Ala Val Thr Asp
                  20                  25                  30

 aac tgt ttg agc ttt agt gta aaa ggc aat ttg ggg act tgc cct gtc      502
 Asn Cys Leu Ser Phe Ser Val Lys Gly Asn Leu Gly Thr Cys Pro Val
              35                  40                  45

 aga att tta gta gca agc ttc tgt gtg cac gtg tgt gtg cat gtg cgt      550
 Arg Ile Leu Val Ala Ser Phe Cys Val His Val Cys Val His Val Arg
          50                  55                  60

 gtg ttt ttt att caa att agt ttg tgt ctg aag agt gga agg aaa tat      598
 Val Phe Phe Ile Gln Ile Ser Leu Cys Leu Lys Ser Gly Arg Lys Tyr
      65                  70                  75

 ttt aaa ttt tta ctt ctc aat tgt gct aat gtt gaa atc agt agt tga      646
 Phe Lys Phe Leu Leu Leu Asn Cys Ala Asn Val Glu Ile Ser Ser 
  80                  85                  90

 ctcatcttta ttaaaatcat tgtcctagag gaagtttata aaatgtttat ttgtagcaat    706

 gatgaattta aatgtatatg ttctaactga atcacatgtc tgcttttccg tctcaaaatt    766

 tatcttgtga tgattcctgt tttaaaaata ttggttttcc ttgtaaattc tgaacataca    826

 gccttgttta atataggatc cttattttaa aaaattattt taaaattgat gtaagcttat    886

 taaagtaatg gccggcatga aatctgggaa aatactcaaa aaaggttaag ggagaaaaac    946

 aatcattatt tttagcagga gataactggt at                                  978




      <210> 242
      <211> 7387
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (255)..(2354)

      <400> 242
 ccctctctgc cttctgtcct gagaggcttt ctgatggaag ggcggggact tcaggagcgg     60

 ccctcccttg ttgagatggg gtgctctgac agcaccttta actttaaaga cctccagggc    120

 ccagccctga cagccacagt gggtcttatt tgagtcggtg atgcagaaac agaggcctgt    180

 gcttcttcag cttctgggaa acctacttcc aagagtctac tcaccgggcc ggctgtgttg    240

 tggaaaatag tcta  atg cgg cct ctg aca tgt aat tca ttt acc gag agc     290
                  Met Arg Pro Leu Thr Cys Asn Ser Phe Thr Glu Ser
                    1               5                  10

 ctt ccg gag cag tac tac agc ctc acc tgg ttc ctg agc ccc atc ctt      338
 Leu Pro Glu Gln Tyr Tyr Ser Leu Thr Trp Phe Leu Ser Pro Ile Leu
          15                  20                  25

 ggc ctc atc ttc aca cct ctc att ggg tct gcg agt gac cgg tgc acc      386
 Gly Leu Ile Phe Thr Pro Leu Ile Gly Ser Ala Ser Asp Arg Cys Thr
      30                  35                  40

 ctg agc tgg ggc cgc cgg cgg ccc ttc atc ctc gcc ctc tgc gtt ggc      434
 Leu Ser Trp Gly Arg Arg Arg Pro Phe Ile Leu Ala Leu Cys Val Gly
  45                  50                  55                  60

 gtc ctc ttt ggc gtt gca ctt ttc ctt aac ggc tct gcc atc ggt ctg      482
 Val Leu Phe Gly Val Ala Leu Phe Leu Asn Gly Ser Ala Ile Gly Leu
                  65                  70                  75

 gcc ctc ggc gat gtc ccc aac cgg cag ccc atc ggc atc gtg ctc acg      530
 Ala Leu Gly Asp Val Pro Asn Arg Gln Pro Ile Gly Ile Val Leu Thr
              80                  85                  90

 gtg ctg gga gtg gtg gtc ctg gac ttc agc gcc gat gcc acc gag ggg      578
 Val Leu Gly Val Val Val Leu Asp Phe Ser Ala Asp Ala Thr Glu Gly
          95                 100                 105

 ccc atc cgt gcc tat ctg ctg gac gtg gtg gac agc gag gag cag gac      626
 Pro Ile Arg Ala Tyr Leu Leu Asp Val Val Asp Ser Glu Glu Gln Asp
     110                 115                 120

 atg gcc ctc aac atc cac gcc ttc tct gcc ggc ctc ggc gga gcc atc      674
 Met Ala Leu Asn Ile His Ala Phe Ser Ala Gly Leu Gly Gly Ala Ile
 125                 130                 135                 140

 ggc tac gtg ctg ggt ggg ctg gac tgg acc cag acc ttc ctg ggc agc      722
 Gly Tyr Val Leu Gly Gly Leu Asp Trp Thr Gln Thr Phe Leu Gly Ser
                 145                 150                 155

 tgg ttc cgg acc cag aac cag gtg ctc ttc ttc ttt gcc gcc atc atc      770
 Trp Phe Arg Thr Gln Asn Gln Val Leu Phe Phe Phe Ala Ala Ile Ile
             160                 165                 170

 ttc acg gtg tcc gtg gcc ctg cac ctg ttc agc atc gac gag gag cag      818
 Phe Thr Val Ser Val Ala Leu His Leu Phe Ser Ile Asp Glu Glu Gln
         175                 180                 185

 tac agc ccg cag cag gag cgc agc gct gag gag ccc ggc gcc ctg gat      866
 Tyr Ser Pro Gln Gln Glu Arg Ser Ala Glu Glu Pro Gly Ala Leu Asp
     190                 195                 200

 ggg ggc gag ccg cac ggc gtc cct gcc ttc cca gac gag gta cag tcg      914
 Gly Gly Glu Pro His Gly Val Pro Ala Phe Pro Asp Glu Val Gln Ser
 205                 210                 215                 220

 gag cac gag ctg gcc ctg gac tac ccg gac gtg gac atc atg cgc agc      962
 Glu His Glu Leu Ala Leu Asp Tyr Pro Asp Val Asp Ile Met Arg Ser
                 225                 230                 235

 aaa agc gac tcg gcg ttg cac gtg ccg gac acc gcg ctg gac ctg gag     1010
 Lys Ser Asp Ser Ala Leu His Val Pro Asp Thr Ala Leu Asp Leu Glu
             240                 245                 250

 ccc gag ctg ctg ttc ctg cac gac atc gag ccc tcc atc ttc cac gac     1058
 Pro Glu Leu Leu Phe Leu His Asp Ile Glu Pro Ser Ile Phe His Asp
         255                 260                 265

 gcc tcc tac ccc gcc acc ccc cgc agc acc agc cag gag ctc gcc aag     1106
 Ala Ser Tyr Pro Ala Thr Pro Arg Ser Thr Ser Gln Glu Leu Ala Lys
     270                 275                 280

 acc aag ctg ccc cgc ctg gcc acc ttc ctc aag gaa gcc gcc aag gag     1154
 Thr Lys Leu Pro Arg Leu Ala Thr Phe Leu Lys Glu Ala Ala Lys Glu
 285                 290                 295                 300

 gac gag acc ttg ctg gat aat cac ttg aat gaa gct aaa gtc cca aac     1202
 Asp Glu Thr Leu Leu Asp Asn His Leu Asn Glu Ala Lys Val Pro Asn
                 305                 310                 315

 gga agt ggc tcc ccc aca aaa gac gcc ctc ggc ggc tac acc agg gtg     1250
 Gly Ser Gly Ser Pro Thr Lys Asp Ala Leu Gly Gly Tyr Thr Arg Val
             320                 325                 330

 gac acg aag ccc tcg gcc acg tcg agc tcc atg cgg cgg cgg cgg cac     1298
 Asp Thr Lys Pro Ser Ala Thr Ser Ser Ser Met Arg Arg Arg Arg His
         335                 340                 345

 gcg ttc cgc agg cag gcc tcc agc acc ttc tcc tac tac ggc aag ctt     1346
 Ala Phe Arg Arg Gln Ala Ser Ser Thr Phe Ser Tyr Tyr Gly Lys Leu
     350                 355                 360

 ggg tcc cac tgc tac cgc tac cgg cgc gcc aac gcc gtg gtg ctg atc     1394
 Gly Ser His Cys Tyr Arg Tyr Arg Arg Ala Asn Ala Val Val Leu Ile
 365                 370                 375                 380

 aag ccg tcg cgc agc atg agc gac ctg tac gac atg cag aag cgg cag     1442
 Lys Pro Ser Arg Ser Met Ser Asp Leu Tyr Asp Met Gln Lys Arg Gln
                 385                 390                 395

 cgg cag cac cgg cac cgg aac cag agc ggg gcc acc acc tcc agc ggg     1490
 Arg Gln His Arg His Arg Asn Gln Ser Gly Ala Thr Thr Ser Ser Gly
             400                 405                 410

 gac acc gag agt gag gag ggg gag ggc gag acc acg gtg cgc ctg ctg     1538
 Asp Thr Glu Ser Glu Glu Gly Glu Gly Glu Thr Thr Val Arg Leu Leu
         415                 420                 425

 tgg ctc tcc atg ctg aag atg ccc agg gag ctg atg cgg ctg tgc ctc     1586
 Trp Leu Ser Met Leu Lys Met Pro Arg Glu Leu Met Arg Leu Cys Leu
     430                 435                 440

 tgc cac ctc ctc acc tgg ttc tct gtc atc gcc gag gcc gtg ttc tac     1634
 Cys His Leu Leu Thr Trp Phe Ser Val Ile Ala Glu Ala Val Phe Tyr
 445                 450                 455                 460

 acc gac ttc atg ggc cag gtc atc ttc gaa ggc gac ccc aag gcc ccc     1682
 Thr Asp Phe Met Gly Gln Val Ile Phe Glu Gly Asp Pro Lys Ala Pro
                 465                 470                 475

 tcg aac tcg acc gcc tgg caa gcc tac aac gcc ggg gtc aag atg ggc     1730
 Ser Asn Ser Thr Ala Trp Gln Ala Tyr Asn Ala Gly Val Lys Met Gly
             480                 485                 490

 tgc tgg ggc ctg gtc att tat gcc gcc act ggt gct att tgt tca gcc     1778
 Cys Trp Gly Leu Val Ile Tyr Ala Ala Thr Gly Ala Ile Cys Ser Ala
         495                 500                 505

 ctg tta cag aag tac ttg gac aac tac gac ctg agc gtc agg gtg atc     1826
 Leu Leu Gln Lys Tyr Leu Asp Asn Tyr Asp Leu Ser Val Arg Val Ile
     510                 515                 520

 tac gtg ctg ggg acg ctg ggc ttc tct gtt ggc aca gcc gtg atg gcc     1874
 Tyr Val Leu Gly Thr Leu Gly Phe Ser Val Gly Thr Ala Val Met Ala
 525                 530                 535                 540

 atg ttt ccc aac gtc tac gtc gcc atg gtc acc atc agc acc atg ggc     1922
 Met Phe Pro Asn Val Tyr Val Ala Met Val Thr Ile Ser Thr Met Gly
                 545                 550                 555

 atc gtc tcc atg agc atc tcc tac tgc ccg tac gcc ctg ctg ggc cag     1970
 Ile Val Ser Met Ser Ile Ser Tyr Cys Pro Tyr Ala Leu Leu Gly Gln
             560                 565                 570

 tac cat gac atc aag cag tac atc cac cac agc ccc ggg aac tcc aag     2018
 Tyr His Asp Ile Lys Gln Tyr Ile His His Ser Pro Gly Asn Ser Lys
         575                 580                 585

 cga ggg ttt ggc ata gat tgt gcc atc ctg tcc tgc caa gtg tac atc     2066
 Arg Gly Phe Gly Ile Asp Cys Ala Ile Leu Ser Cys Gln Val Tyr Ile
     590                 595                 600

 tcg cag atc ctg gtg gcc tct gcc ctt ggg ggc gtg gtc gac gcc gtg     2114
 Ser Gln Ile Leu Val Ala Ser Ala Leu Gly Gly Val Val Asp Ala Val
 605                 610                 615                 620

 ggg act gtc cgc gtc atc ccc atg gtg gcc tct gtg ggc tct ttc ctg     2162
 Gly Thr Val Arg Val Ile Pro Met Val Ala Ser Val Gly Ser Phe Leu
                 625                 630                 635

 ggc ttc ctg acg gcc aca ttc ctg gtg atc tat ccc gac gtg tca gag     2210
 Gly Phe Leu Thr Ala Thr Phe Leu Val Ile Tyr Pro Asp Val Ser Glu
             640                 645                 650

 gag gcc aag gag gag cag aaa ggc ctg tct tcc ccg ttg gcc ggc gaa     2258
 Glu Ala Lys Glu Glu Gln Lys Gly Leu Ser Ser Pro Leu Ala Gly Glu
         655                 660                 665

 ggc agg gcc ggc ggg aac agc gaa aag ccc acc gtg ctg aag ctc acg     2306
 Gly Arg Ala Gly Gly Asn Ser Glu Lys Pro Thr Val Leu Lys Leu Thr
     670                 675                 680

 cgg aag gag ggc ctg cag gga ccg gtg gag aca gag tcc gtg gtc tga     2354
 Arg Lys Glu Gly Leu Gln Gly Pro Val Glu Thr Glu Ser Val Val 
 685                 690                 695

 gccgcactcc cgtttacaca cattccagcg ggcgggtggg cgggcgggcg ggcggcgggg   2414

 ccaggccatg ggcgggagca gagacaccgc ggaaccctgc agatgctgtg gccgacccgg   2474

 cagtgcgggc cagagcccct ccgcccccat agccacaatt cagtagtcgt agggtaggtt   2534

 tgagctacta agcaaatacc acactaacca ctttttcgat aattaaaaga atcatttgaa   2594

 atattttttt taattgaaaa agatatttta atttcagctc ttttattctg caggtgtatt   2654

 attctgcatg tttttaaatg atataaaaca tttatataga caataagcaa cttagaaaaa   2714

 ataagatttt gcatttctaa aattataatt gaaaacaaaa tctgacattc tctgctaagt   2774

 cttatctgaa tgcttcagat aatggtagtg tagtcagtga ctaaaatatt tttatcaaat   2834

 ttcctctctg tagacgcctg caggtattga cgtctgtcag atctcgtcac attggctggt   2894

 gccgcagctg ttggagagta tttttcttta tgattatttt agaaaaaaaa ttttcttttc   2954

 cacaatgtgg ttctcttaga agaatgacgt atcttctttt cctcagcgag ttggacacat   3014

 tgtgcccagg gcagccctgt ccttgggcag cgaccgcaca ccaaagctgg gaggaggctg   3074

 gtccgggggg cctgggcaga agacagtgat ttgcaggggt ggctcccaga caccctgccc   3134

 agggatgggc tgggcaccac ctgggggcgg agcgtgagct ccagacgagc tcctgcgtgc   3194

 gcgtgtgagt gtgtctgcgc ccagccatgt gaccctgctc gtcccgtctg aaggactctc   3254

 ctaggaggcc aggttgcccc tccagacccc tcccaacgtc agggggaagg aaacgttgac   3314

 tttcactgca ctttgattcg tctctaaacc atttgctggg gattcctgag agcagagctc   3374

 ccagcgggcc ctgcctccca agtcccgccg caaggctacc tcgggtgtgt ggatgtgcga   3434

 gggcctcccc cgcttgcgaa ggggacatgc gtgctggaac ctgtcggaac tccatgcctt   3494

 cctcgcctgc tcacctgctc gacgctggaa tcgggacagg tgcaaaggga cgcagacgtc   3554

 tgggacagct aaggcccgtg tcaccggagg gctccgcaca gtcgttctgg tttcaacaaa   3614

 taagcaaaac tcgggcaagt actgcagcta tttggaaatg ttttccaaac cacagtctct   3674

 ttagaactaa gcctatttga aacggtcggt gtaggcttac tgagatcagg agacagggag   3734

 gccccgcaca tcacacagat aaagtcagac aattgtaatt aatacttttg ctgcctcaag   3794

 ttgtttttta aataaagtac tttgaaatgc atgagaatca tgctgcaata tgatcattct   3854

 agagcaaata tatatataca cgtatatata tttcaagatg aaactaaagc agtttttaaa   3914

 taaattactt gaattttctg tgtatttaaa ggaacgactg tttaatgtac ttgatgggcc   3974

 tctggtcttg ccgtgtctcc tgccgctggt ggcactttgt agattgtgtg tttgtgtccg   4034

 ggtggcagtt gggtacctgc tcacgcacgg tgtgtctgcc aggccacggt gtcccaggat   4094

 cgcagagggc tgactttcaa gacttcaaga acattttctg gatgtgtgga aacttgagaa   4154

 tggccttgtg aatctcgtgc ttggacaggg caagtccgac tactgaaagt gctgccagct   4214

 ttgctgcgag ccctccggcc aggcgggagc cccgtgggct gggcactgtg gcccttcttc   4274

 tctgggggac ggaacccctg gcgttcctca cctcggccgg gcgtccgtgg cagctcagct   4334

 ctatgcaact tgatcctcta gcggctttaa gactgtagat cccctctctg agacctggct   4394

 gtacttgtca ggatctcgag gcgcagctcc cgtcttagct ggtttctccg gcttctcgtc   4454

 ctgacgacta taaaacagtt ggaggcaaga aagcagcgga tgtggggtgg cagtggcctg   4514

 acccgaatca agatccgacc caaaccacac caaatgtggg ttcatctggg ggccacccct   4574

 tgcctgaggc ttcccaccct catctgaagg cccaggggcc ggatccaggg ctcaccaaag   4634

 ccgattcctc gccagctggg agtgcagaag tctcagggcc tggctgcgac ttgattttta   4694

 ggaggaagag gggcttcgca acccccctct gaatagtgtg ttaacccttg agatcccagc   4754

 ctcgactaat ctgaagtaag gacaacaaag gccattcagt gccctccaca tggccttgcc   4814

 acagtcactg tcagggtatg aacgtgccgg aagccagtgc cagccaggga caggcgtgac   4874

 tgttgtgtgc tcctcggtga caggagtcgg tggctgcaca ctttgtagac tcgtcaagct   4934

 gtcagcactt caggtgtttg caagcaaagc ccttcttagt gtgcaggtca gtgtgcagag   4994

 cccaaatgag gggaccgcag gggctggggt ccagggtcag tagagtcggt ttctggagct   5054

 gccttcctgg gaggcaggtg tgggtgaccg gggctctggc ggtgcgtgtg ggcccggcct   5114

 ggccacagcg gggaccaggt cacgacatct ttggcctcaa cccctcccct gcactgagat   5174

 tatttccaga ttgcactcac ttgaaaccgt ccgtgtcgtc accttgtgtc ttaagggaag   5234

 ccgagaagaa gggcagacgg gcaggctgtc ttgtctgcaa agcgccattg cgcccgcagc   5294

 ttgtgtgggt caggctgcag ctcgggtgtc tgtggcttct aaccttgtac ctcagacgga   5354

 tgcagtaaca aggcggggct ggggacgccg gtcagtgtca aaggggaggt gctctggctg   5414

 atagccttgc ccgagaggga cgaggaggcc gtgcgggtgc cccctgggga agctggccag   5474

 ccatccagtg ctgaggacgc agctggagtt gggctcgtgg cacccttggg gtgtgggctg   5534

 tgcaggctgg tggcctgggt gcctctgcac actgagtgga gtgtcaggca gggtgtgtcg   5594

 gttggtcgag tcttgtgtaa tgtgcgcaga ccagttacca aactaggata atgttggtct   5654

 catttgtggt ggttttgttc cctatacaag tcagctaagt aaagactctt ttaacgagct   5714

 tccccttaac acatggcaga agtttccagg tgcaggaatg cgagctggcg ggaaggggca   5774

 gaggccgtga gctctcagct gggccggcct gcctgtgtcc cctttcctgg gtctgtcggc   5834

 agactggcat catgacgttc cctggtggct gaagagctag ctttggagtg ttgtttttct   5894

 cactctcagg caggggcctt agctggaatc ctccaacctg ccactgaaca cgtcagtgct   5954

 gtgtgctgcc tcttggacac ctgcccttga aagcctcagg cccctgggag aagcactctg   6014

 tccagtcctg tccccggggg ggaggcaggg ccactgagcc ctcctcagat ggttagtggc   6074

 ttccaacagc catcaggagt gtttcttgaa tgccccaggt gtggaggact tggtctgtga   6134

 ccacctagaa ccccagagct gaacaggaag ccgtccctgc agcaacaaga gggctggaag   6194

 ggggagctgc aggccaccct cggctctccc actgctgggg cggtgatgtt cgggtgacat   6254

 gtttgaaaaa tactcttaaa gataccaact gttcccttat atggctaatg gtttgtgcag   6314

 ccaccagcga tggcggcccc tattagagac caggtttgtt aaaacaccaa atattgctgt   6374

 ccacactaga cattaaccgg cttcagaaaa gatggacacc ttttcccacg ctgtttcgct   6434

 tcttaacttt ggtccagctt tagccaccac acagcgtgtg agggactgct gctgcggagt   6494

 cagcctcgtt tgtccctccg cctcccacca gcatgcgccg cttctgagag acaccagctc   6554

 cctgcctcca agcctggtgc cacaggcctg tcgtgaggga cccctgcttc cgagagctcc   6614

 tgggggggtt ctgcccttca ccacctggga gaggtgtcag ttcagttccg agttgaacaa   6674

 ggcccgtgca cacagcatgt tgggggccca gcccaaagtt cttgtcacct cctcatgcaa   6734

 agccagccat caccctccgg ccagagctca aggtggcccc ttggccagcc cctccttggg   6794

 tcctccagga ggactgagca cccctcctag cggcatccct tgccctccac agtgctgcca   6854

 ggggcacgtc gctctgtgcc gtggactgag accatcccct ggtgacagaa tgacccgttt   6914

 gttggaaatg cctcgttgcc agagaaactc cccaggcatc tcggaacgaa actatttagt   6974

 tccattgtga actggccacg ggacagcttt ttatcaactt attaagttgg agcactgtaa   7034

 tcgcgcttgc tgagttagca gtggtggtaa gcgtgtgtta aacacataat gttacgtttt   7094

 aggagagaga ggtcgtaagg aagtgtcgtg tcgctcatga ctctcttcta ttagttgggt   7154

 aacagtggcc tcatgtttgt gtctgtgtgt acacagagcc cttaggttct gctctgtttc   7214

 tttgccaggt gaatgtttgt ggcatgcgct gctgtccgcg cccctctgtc ctgcgcaggg   7274

 ttcagctgtg cggcgccctg atttcctcca tgcacacaga acctccttgt gtctgtttct   7334

 ctgttcctct gtggctgact caataaactt ttccctctga aaaaaaaaaa aaa          7387




      <210> 243
      <211> 2753
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (68)..(2479)

      <220>
      <221> misc_feature
      <222> (1)...(2753)
      <223> n = a,t,c or g

      <400> 243
 cccctgctcc attctcttgg tccaggagct gcccagatcc agattcccct ccagcctgac     60

 tctgtcc  atg tcc agc tcc gct gct gga gct cca gac caa gcc att tca     109
          Met Ser Ser Ser Ala Ala Gly Ala Pro Asp Gln Ala Ile Ser
            1               5                  10

 att agc cta gag gcc cag gga cag gga cag agt cag gct gga ggg gaa      157
 Ile Ser Leu Glu Ala Gln Gly Gln Gly Gln Ser Gln Ala Gly Gly Glu
  15                  20                  25                  30

 tct gga tct ggg cag ctc ctg gac caa gag aat gga gca ggg ggt gag      205
 Ser Gly Ser Gly Gln Leu Leu Asp Gln Glu Asn Gly Ala Gly Gly Glu
                  35                  40                  45

 tac atg agc tgc ttc gag gcc cag ggc ttc aag tgg aac ctg tat gag      253
 Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn Leu Tyr Glu
              50                  55                  60

 gtg gtg agg gtg ccc ttg aag gcg aca gat gtg gct cga ctt cca tac      301
 Val Val Arg Val Pro Leu Lys Ala Thr Asp Val Ala Arg Leu Pro Tyr
          65                  70                  75

 cag ctg tcc atc tcc tgt gcc acc tcc cct ggc ttc cag ctg agc tgc      349
 Gln Leu Ser Ile Ser Cys Ala Thr Ser Pro Gly Phe Gln Leu Ser Cys
      80                  85                  90

 tgc atc ccc agc aca aac ctg gcc tac acc gcg gcc tgg agc cct gga      397
 Cys Ile Pro Ser Thr Asn Leu Ala Tyr Thr Ala Ala Trp Ser Pro Gly
  95                 100                 105                 110

 gag ggc agc aaa gct tcc tcc ttc aac gag tca ggc tct cag tgc ttt      445
 Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser Gln Cys Phe
                 115                 120                 125

 gtg ctg gct gtt cag cgc tgc ccg atg gct gac acc acg tac gct tgt      493
 Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp Thr Thr Tyr Ala Cys
             130                 135                 140

 gac ctg cag agc ctg ggc ctg gct cca ctc agg gtc ccc atc tcc atc      541
 Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro Ile Ser Ile
         145                 150                 155

 acc atc atc cag gat gga gac atc acc tgc cct gag gac gcc tcg gtg      589
 Thr Ile Ile Gln Asp Gly Asp Ile Thr Cys Pro Glu Asp Ala Ser Val
     160                 165                 170

 ctc acc tgg aat gtc acc aag gct ggc cac gtg gca cag gcc cca tgt      637
 Leu Thr Trp Asn Val Thr Lys Ala Gly His Val Ala Gln Ala Pro Cys
 175                 180                 185                 190

 cct gag agc aag agg ggc ata gtg agg agg ctc tgt ggg gct gac gga      685
 Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly Ala Asp Gly
                 195                 200                 205

 gtc tgg ggg ccg gtc cac agc agc tgc aca gat gcg agg ctc ctg gcc      733
 Val Trp Gly Pro Val His Ser Ser Cys Thr Asp Ala Arg Leu Leu Ala
             210                 215                 220

 ttg ttc act aga acc aag ctg ctg cag gca ggc cag ggc agt cct gct      781
 Leu Phe Thr Arg Thr Lys Leu Leu Gln Ala Gly Gln Gly Ser Pro Ala
         225                 230                 235

 gag gag gtg cca cag atc ctg gca cag ctg cca ggg cag gcg gca gag      829
 Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln Ala Ala Glu
     240                 245                 250

 gca agt tca ccc tcc gac tta ctg acc ctg ctg agc acc atg aaa tac      877
 Ala Ser Ser Pro Ser Asp Leu Leu Thr Leu Leu Ser Thr Met Lys Tyr
 255                 260                 265                 270

 gtg gcc aag gtg gtg gca gag gcc aga ata cag ctt gac cgc aga gcc      925
 Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp Arg Arg Ala
                 275                 280                 285

 ctg aag aat ctc ctg att gcc aca gac aag gtc cta gat atg gac acc      973
 Leu Lys Asn Leu Leu Ile Ala Thr Asp Lys Val Leu Asp Met Asp Thr
             290                 295                 300

 agg tct ctg tgg acc ctg gcc caa gcc cgg aag ccc tgg gca ggc tcg     1021
 Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp Ala Gly Ser
         305                 310                 315

 act ctc ctg ctg gct gtg gag acc ctg gca tgc agc ctg tgc cca cag     1069
 Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu Cys Pro Gln
     320                 325                 330

 gac cac ccc ttc gcc ttc agc tta ccc aat gtg ctg ctg cag agc cag     1117
 Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu Gln Ser Gln
 335                 340                 345                 350

 ctg ttt gga ccc acg ttt cct gct gac tac agc atc tcc ttc cct act     1165
 Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser Phe Pro Thr
                 355                 360                 365

 cgg ccc cca ctg cag gct cag att ccc agg cac tca ctg gcc cca ttg     1213
 Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu Ala Pro Leu
             370                 375                 380

 gtc cgt aat gga act gaa ata agt att act agc ctg gtg ctg cga aaa     1261
 Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val Leu Arg Lys
         385                 390                 395

 ctg gac cac ctt ctg ccc tca aac tat gga caa ggg ctg ggg gat tcc     1309
 Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu Gly Asp Ser
     400                 405                 410

 ctc tat gcc act cct ggc ctg gtc ctt gtc att tcc atc atg gca ggt     1357
 Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile Met Ala Gly
 415                 420                 425                 430

 gac cgg gcc ttc agc cag gga gag gtc atc atg gac ttt ggg aac aca     1405
 Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe Gly Asn Thr
                 435                 440                 445

 gat ggt tcc cct cac tgt gtc ttc tgg gat cac agt ctc ttc cag ggc     1453
 Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu Phe Gln Gly
             450                 455                 460

 agg ggg ggt tgg tcc aaa gaa ggg tgc cag gca cag gtg gcc agt gcc     1501
 Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val Ala Ser Ala
         465                 470                 475

 agc ccc act gct cag tgc ctc tgc cag cac ctc act gcc ttc tcc gtc     1549
 Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala Phe Ser Val
     480                 485                 490

 ctc atg tcc cca cac act gtt ccg gaa gaa ccc gct ctg gcg ctg ctg     1597
 Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu Ala Leu Leu
 495                 500                 505                 510

 act caa gtg ggc ttg gga gct tcc ata ctg gcg ctg ctt gtg tgc ctg     1645
 Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu Val Cys Leu
                 515                 520                 525

 ggt gtg tac tgg ctg gtg tgg aga gtc gtg gtg cgg aac aag atc tcc     1693
 Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn Lys Ile Ser
             530                 535                 540

 tat ttc cgc cac gcc gcc ctg ctc aac atg gtg ttc tgc ttg ctg gcc     1741
 Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys Leu Leu Ala
         545                 550                 555

 gca gac act tgc ttc ctg ggc gcc cca ttc ctc tct cca ggg ccc cga     1789
 Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro Gly Pro Arg
     560                 565                 570

 agc ccg ctc tgc ctt gct gcc gcc ttc ctc tgt cat ttc ctc tac ctg     1837
 Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe Leu Tyr Leu
 575                 580                 585                 590

 gcc acc ttt ttc tgg atg ctg gcg cag gcc ctg gtg ttg gcc cac cag     1885
 Ala Thr Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu Ala His Gln
                 595                 600                 605

 ctg ctc ttt gtc ttt cac cag ctg gca aag cac cga gtt ctc ccc ctc     1933
 Leu Leu Phe Val Phe His Gln Leu Ala Lys His Arg Val Leu Pro Leu
             610                 615                 620

 atg gtg ctc ctg ggc tac ctg tgc cca ctg ggg ttg gca ggt gtc acc     1981
 Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala Gly Val Thr
         625                 630                 635

 ctg ggg ctc tac cta cct caa ggg caa tac ctg agg gag ggg gaa tgc     2029
 Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu Gly Glu Cys
     640                 645                 650

 tgg ttg gat ggg aag gga ggg gcg tta tac acc ttc gtg ggg cca gtg     2077
 Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Thr Phe Val Gly Pro Val
 655                 660                 665                 670

 ctg gcc atc ata ggc gtg aat ggg ctg gta cta gcc atg gcc atg ctg     2125
 Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala Met Leu
                 675                 680                 685

 aag ttg ctg aga cct tcg ctg tca gag gga ccc cca gca gag aag cgc     2173
 Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu Lys Arg
             690                 695                 700

 caa gct ctg ctg ggg gtg atc aaa gcc ctg ctc att ctt aca ccc atc     2221
 Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr Pro Ile
         705                 710                 715

 ttt ggc ctc acc tgg ggg ctg ggc ctg gcc act ctg tta gag gaa gtc     2269
 Phe Gly Leu Thr Trp Gly Leu Gly Leu Ala Thr Leu Leu Glu Glu Val
     720                 725                 730

 tcc acg gtc cct cat tac atc ttc acc att ctc aac acc ctc cag ggc     2317
 Ser Thr Val Pro His Tyr Ile Phe Thr Ile Leu Asn Thr Leu Gln Gly
 735                 740                 745                 750

 gtc ttc atc cta ttg ttt ggt tgc ctc atg gac agg aag ata caa gaa     2365
 Val Phe Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu
                 755                 760                 765

 gct ttg cgc aaa cgc ttc tgc cgc gcc caa gcc ccc agc tcc acc atc     2413
 Ala Leu Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser Ser Thr Ile
             770                 775                 780

 tcc ctg gcc aca aat gaa ggc tgc atc ttg gaa cac agc aaa gga gga     2461
 Ser Leu Ala Thr Asn Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly
         785                 790                 795

 agc gac act gcc agg tga gaacta ggctttctca ggggcagcgt aagcagggtg     2515
 Ser Asp Thr Ala Arg 
     800

 gattgaggac ggtgtggcaa agggcctcct ggcaaagtgc tggagagaag cctcctcttt   2575

 ctatacccag cccacaccaa agggtaggaa acaggttttt ctagggtagc cattgctaga   2635

 tggctgggag acggtggaac atgtcagaga gcagaaaaca tagcccctta tcttaaattc   2695

 caagaaagca agaagtttca ccaccacctg tattagnccg gtggntgtac gagggacg     2753




      <210> 244
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(789)

      <400> 244
 caacacggaa agcccagagc agaggaggga gaaggcccca ttctctcagc tttaatctac     60

 tgcacctcgg agggcagagc tctaaccaga cacgctgcaa gcatcagaat cggg  atg     117
                                                              Met
                                                                1

 aac atc gag gtg ggg aac att tct tat aca gga gcc atc atc tcc tgg      165
 Asn Ile Glu Val Gly Asn Ile Ser Tyr Thr Gly Ala Ile Ile Ser Trp
               5                  10                  15

 tcg tcc tcg gag ccc tgc ctg gag gac tat tac cat att atg tac agg      213
 Ser Ser Ser Glu Pro Cys Leu Glu Asp Tyr Tyr His Ile Met Tyr Arg
          20                  25                  30

 ccc aac tgg aac agc atc ttc tct ggc tat ctt cgc tac agc ttc cac      261
 Pro Asn Trp Asn Ser Ile Phe Ser Gly Tyr Leu Arg Tyr Ser Phe His
      35                  40                  45

 cac gag gag aag gtg cct cga acg atc agc tcc gtg gtg ctg gaa cat      309
 His Glu Glu Lys Val Pro Arg Thr Ile Ser Ser Val Val Leu Glu His
  50                  55                  60                  65

 ctt gcc cct tcc act ctc tac ttc ctg tgc atc agc tgt aag aag gct      357
 Leu Ala Pro Ser Thr Leu Tyr Phe Leu Cys Ile Ser Cys Lys Lys Ala
                  70                  75                  80

 gcc ttc cct tac agg cac tac tgc acc atg ttc cac acc ctg gat aag      405
 Ala Phe Pro Tyr Arg His Tyr Cys Thr Met Phe His Thr Leu Asp Lys
              85                  90                  95

 agt ccg ctg gct cct gga agc tcc ctg gta gac ccc cag atc tcc ctt      453
 Ser Pro Leu Ala Pro Gly Ser Ser Leu Val Asp Pro Gln Ile Ser Leu
         100                 105                 110

 tgg gtg ctg atg gcc att ctg ctg gcc tgc ttc aca gcc gtc ttg gcc      501
 Trp Val Leu Met Ala Ile Leu Leu Ala Cys Phe Thr Ala Val Leu Ala
     115                 120                 125

 ttc atc tgc ctc cag ttc tgg tgt gtc cgt tgc cat gag ccg cga tgg      549
 Phe Ile Cys Leu Gln Phe Trp Cys Val Arg Cys His Glu Pro Arg Trp
 130                 135                 140                 145

 tct tac agg gct ggc cac atg gag gag gcc aat ggg ttg gtg aga tgg      597
 Ser Tyr Arg Ala Gly His Met Glu Glu Ala Asn Gly Leu Val Arg Trp
                 150                 155                 160

 cca gag gag gcc ccg gat ctt ggt cag agg gag gaa gac ctg cag ggg      645
 Pro Glu Glu Ala Pro Asp Leu Gly Gln Arg Glu Glu Asp Leu Gln Gly
             165                 170                 175

 ctc ccc ctg gtg gaa atg cca cgc aag aac tcc aga gat gga gct gaa      693
 Leu Pro Leu Val Glu Met Pro Arg Lys Asn Ser Arg Asp Gly Ala Glu
         180                 185                 190

 ctg gat ccc gaa gcc aac cag gat gcc cct gat gcg ggt gcc tta cag      741
 Leu Asp Pro Glu Ala Asn Gln Asp Ala Pro Asp Ala Gly Ala Leu Gln
     195                 200                 205

 agg ggg ggt ggt gac cca ccc gct ata ctg cct cat tgt ggg gaa tga      789
 Arg Gly Gly Gly Asp Pro Pro Ala Ile Leu Pro His Cys Gly Glu 
 210                 215                 220

 gagtggggag gagagcgccc gcatcatgta gcctaaagct ttccacacag taggtcgttt    849

 gtacaaatgt                                                           859




      <210> 245
      <211> 2720
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (494)..(1363)

      <400> 245
 gacttaaggg gaccaaaggc tggagctcaa ggatccttaa taaattaatc cccccccccc     60

 ggcctgtatc ccgtgctgtt tccctggcag acacacaggc gctcacgagt ctctccttgc    120

 cagcctgcag ggcggcgacc cccaaaaccc agctccgggt cccaacctag gcaagaagct    180

 gcttctctgc caacagctcc tcttcggcct ccgtcacagc cacctggacc ctaccctttc    240

 gcgactgctg ctgctgctgc ccggacgtgg aagcagcaag aggcgcttgg tcaagacaca    300

 ctgacggtac ctacagaata ctggacatac ggattcagaa tccataaggc tttatcacct    360

 tgaatcaagg atttatttga tatcatcctc ggtctttact tcctatcaag taacattgtt    420

 ttgaaaaata gagttaacac atttgccata agggagtctt tctttttgtt ttaaatactt    480

 cgcatactct cca   atg ccc aaa aat agc aag gtg gta aaa aga gaa tta     529
                  Met Pro Lys Asn Ser Lys Val Val Lys Arg Glu Leu
                    1               5                  10

 gat gat gat gtt act gag tct gtc aaa gac ctt ctt tcc aat gaa gac      577
 Asp Asp Asp Val Thr Glu Ser Val Lys Asp Leu Leu Ser Asn Glu Asp
          15                  20                  25

 gca gct gat gat gct ttt aag aca agt gaa cta att gtt gat ggc cag      625
 Ala Ala Asp Asp Ala Phe Lys Thr Ser Glu Leu Ile Val Asp Gly Gln
      30                  35                  40

 gaa gag aaa gat aca gat gtt gaa gaa gga tct gaa gtc gaa gat gaa      673
 Glu Glu Lys Asp Thr Asp Val Glu Glu Gly Ser Glu Val Glu Asp Glu
  45                  50                  55                  60

 aga cca gct tgg aac agt aaa cta caa tac atc ctg gcc caa gtt gga      721
 Arg Pro Ala Trp Asn Ser Lys Leu Gln Tyr Ile Leu Ala Gln Val Gly
                  65                  70                  75

 ttt tct gta ggt tta gga aat gtg tgg cga ttt cca tac cta tgt cag      769
 Phe Ser Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln
              80                  85                  90

 aag aat ggg ggc ggt gca tat ctt tta cca tat tta ata cta ctt atg      817
 Lys Asn Gly Gly Gly Ala Tyr Leu Leu Pro Tyr Leu Ile Leu Leu Met
          95                 100                 105

 gta ata ggt att ccc ctt ttt ttc ttg gaa ctc tct gtg ggt caa aga      865
 Val Ile Gly Ile Pro Leu Phe Phe Leu Glu Leu Ser Val Gly Gln Arg
     110                 115                 120

 att cgg cga ggc agc att ggt gta tgg aat tac ata agc cct aaa ctg      913
 Ile Arg Arg Gly Ser Ile Gly Val Trp Asn Tyr Ile Ser Pro Lys Leu
 125                 130                 135                 140

 ggc ggg att gga ttt gca agt tgt gta gtg tgc tat ttt gta gct ctc      961
 Gly Gly Ile Gly Phe Ala Ser Cys Val Val Cys Tyr Phe Val Ala Leu
                 145                 150                 155

 tac tac aac gtc atc att ggc tgg agt ttg ttt tat ttt tct cag tct     1009
 Tyr Tyr Asn Val Ile Ile Gly Trp Ser Leu Phe Tyr Phe Ser Gln Ser
             160                 165                 170

 ttt cag caa ccc ctg cct tgg gat cag tgt cct ttg gtg aaa aat gct     1057
 Phe Gln Gln Pro Leu Pro Trp Asp Gln Cys Pro Leu Val Lys Asn Ala
         175                 180                 185

 tca cac act ttt gta gaa cca gaa tgt gaa caa agt tct gcc acc acc     1105
 Ser His Thr Phe Val Glu Pro Glu Cys Glu Gln Ser Ser Ala Thr Thr
     190                 195                 200

 tat tac tgg tac agg gaa gca ctg aat att tca agt tcc att tct gaa     1153
 Tyr Tyr Trp Tyr Arg Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser Glu
 205                 210                 215                 220

 agt ggg ggc tta aac tgg aag atg acc atc tgc ttg ttg gct gcc tgg     1201
 Ser Gly Gly Leu Asn Trp Lys Met Thr Ile Cys Leu Leu Ala Ala Trp
                 225                 230                 235

 gtc atg gtt tgc ttg gct atg atc aaa ggc att cag tct tct gga aaa     1249
 Val Met Val Cys Leu Ala Met Ile Lys Gly Ile Gln Ser Ser Gly Lys
             240                 245                 250

 gtt agt atg tta gag ccc ttc ctc att ctg cta atc acc att tct gga     1297
 Val Ser Met Leu Glu Pro Phe Leu Ile Leu Leu Ile Thr Ile Ser Gly
         255                 260                 265

 ttc atc cct ctc tca aat tct gtt aca gat ttc tgt ggg caa atc aca     1345
 Phe Ile Pro Leu Ser Asn Ser Val Thr Asp Phe Cys Gly Gln Ile Thr
     270                 275                 280

 cat aac act tca ttc tag gtagtt aaatattagt gaaaagtgac acttcaaaag     1399
 His Asn Thr Ser Phe 
 285

 tgtgcttaca tttttaaaaa gacaaataaa aacagtgttt tatagtgaaa tctaaggtta   1459

 attataatct ttccttattt caacaagatc tttaaaattt ttgtgaatac ttaaaagtcc   1519

 tttctttttg ccctttattc aattagtcct aatgtttcag ttctctaatt accaattagt   1579

 taaattatgg aaattgggga aagtggtaaa atgagtaatt cattcatttt gtttgtttga   1639

 tatcatttgt ttctctctgc tgtaggtgtt ctaaggaata gctgcataag acattttgaa   1699

 ataatgtaat gtgaagtgtt tcttaaagct ctgaacatca ttaagtagtt aataataatt   1759

 ccaacaagga attcagagta atgtaaaaga ctaaatatca ttccttctga ggcaaattga   1819

 agattagaat ggttgtggtt taaaaagaca ttaagtgaat tctaggtagc ttgtttgtta   1879

 ttatttttaa aggacgctct aggaaagtaa ttgctattca ctattttgct ttcgtattac   1939

 tttttttttt ttttttcatt atcacagcca ttgttctaaa gctctccaca tctcttggct   1999

 ggatcatagc aagaatttac tgttggctct tctctctgcc gtttaactgt ccagctgtgc   2059

 tattttcctt ttcaaagtat aactgatttc aggctaactt attaccactc atcatcatat   2119

 actagcagga atggcaatag tagtagtagt agcagcagca atagtagaag tagtcataat   2179

 aacaataata ataaatgatg ataaagatgt ttctgacaag aattagggta agaacagtaa   2239

 ttgaagccaa ttatttatta caaatgtatt ttgctttggg tactgtgata actacttttt   2299

 atactttatc ccatttaatt ataaaaacca ctcttgagaa gtaattttta ttttcagaac   2359

 cattttacag atttaaaata aacaggtttg aggaattagt ttaacttatc caaagtttcg   2419

 tggctattaa gttctagtat ttggagtcaa atgcaagtct gtctaaatct agagcccatg   2479

 ttctttaact gcaacactat aatgtctcac cccgtcctag tcccaccaat tagtcaactc   2539

 ttttagggca gaagtctgtc taattcatct ttgcttcctg ttactttata tttaattaaa   2599

 aattttagtg actttttaac ttgtaaattg tagctgattt tacatttatc ttcctgaagg   2659

 aaactctgta tcattttgtc ttttgaattt gtgaatatac ttgttaacac atctaaatat   2719

 c                                                                   2720




      <210> 246
      <211> 2057
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (448)..(1956)

      <400> 246
 agatggagcg gctgcgcggc tctgggacgc ccgtgcgcgg gctgccctat gccatgaggg     60

 acaagcgcct catctggcct cttcggcaca ggaattcggt cctacttcac cttcctccgc    120

 ttcctgctgc tactcaacct gctgagcctg ctgctcaccg caagcttcgt gctgctgccc    180

 ctggtctggc tccgcccccc tgacccaggc cccaccctga acttgaccct ccagtgccct    240

 ggtagccgcc agtccccgcc tggcgttttg aggttccaca atcaactttg gcatgttttg    300

 actggcaggg ccttcaccaa cacctatctc ttctacggtg cgtaccgagt ggggccggag    360

 agcagctccg tgtacagcat ccgcctggcc tacctcctca gcccgctggc ctgcctgctc    420

 ctctgcttct gtgggactct gcggcgg    atg gtg aag ggg ctg ccg cag aag     471
                                  Met Val Lys Gly Leu Pro Gln Lys
                                    1               5

 act ctg ctg ggt cag ggc tat cag gcg cct ctc agc gcc aag gtc ttc      519
 Thr Leu Leu Gly Gln Gly Tyr Gln Ala Pro Leu Ser Ala Lys Val Phe
      10                  15                  20

 tcc tca tgg gac ttc tgc atc cgg gtg cag gaa gca gcc acc atc aag      567
 Ser Ser Trp Asp Phe Cys Ile Arg Val Gln Glu Ala Ala Thr Ile Lys
  25                  30                  35                  40

 aag cat gag atc agc aac gag ttc aag gtg gag ctg gag gag ggc cgt      615
 Lys His Glu Ile Ser Asn Glu Phe Lys Val Glu Leu Glu Glu Gly Arg
                  45                  50                  55

 cgc ttc cag ctg atg cag cag cag acc cgg gcc cag acg gcc tgc cgc      663
 Arg Phe Gln Leu Met Gln Gln Gln Thr Arg Ala Gln Thr Ala Cys Arg
              60                  65                  70

 ctg ctc tcc tac ctg cgg gtc aac gta ctc atc ggg ctc ctg gtg gtt      711
 Leu Leu Ser Tyr Leu Arg Val Asn Val Leu Ile Gly Leu Leu Val Val
          75                  80                  85

 ggg gcc atc agc gcc atc ttc tgg gct acc aag tac tca cag gac aac      759
 Gly Ala Ile Ser Ala Ile Phe Trp Ala Thr Lys Tyr Ser Gln Asp Asn
      90                  95                 100

 aag gag gag tcc ctg ttt ctg ctg ctc cag tac ctg ccc cct ggg gtc      807
 Lys Glu Glu Ser Leu Phe Leu Leu Leu Gln Tyr Leu Pro Pro Gly Val
 105                 110                 115                 120

 atc gcc ctg gtc aac ttc ctg ggt ccc ctg ctg ttc aca ttt ctg gtc      855
 Ile Ala Leu Val Asn Phe Leu Gly Pro Leu Leu Phe Thr Phe Leu Val
                 125                 130                 135

 cag ctg gag aac tac cct ccc aac acg gag gtc aac ctc act ctg atc      903
 Gln Leu Glu Asn Tyr Pro Pro Asn Thr Glu Val Asn Leu Thr Leu Ile
             140                 145                 150

 tgg tgc gtg gtg ctg aag ctg gcc agc ttg ggg atg ttc tcc gtc tcc      951
 Trp Cys Val Val Leu Lys Leu Ala Ser Leu Gly Met Phe Ser Val Ser
         155                 160                 165

 ctg ggt cag acc ata ctg tgc att ggc aga gac aag agc agc tgt gag      999
 Leu Gly Gln Thr Ile Leu Cys Ile Gly Arg Asp Lys Ser Ser Cys Glu
     170                 175                 180

 tcc tac ggc tac aac gtt tgt gac tat cag tgc tgg gag aac tcc gtg     1047
 Ser Tyr Gly Tyr Asn Val Cys Asp Tyr Gln Cys Trp Glu Asn Ser Val
 185                 190                 195                 200

 ggg gag gag ctg tac aag ctg agt atc ttc aac ttc ctc ctc acc gtg     1095
 Gly Glu Glu Leu Tyr Lys Leu Ser Ile Phe Asn Phe Leu Leu Thr Val
                 205                 210                 215

 gcc ttc gcc ttc ctg gtc acc ctg cct cgg agg ctg ctg gtg gac cgg     1143
 Ala Phe Ala Phe Leu Val Thr Leu Pro Arg Arg Leu Leu Val Asp Arg
             220                 225                 230

 ttc tca ggc cgg ttc tgg gcc tgg ctg gaa cgg gag gag ttc ctg gtc     1191
 Phe Ser Gly Arg Phe Trp Ala Trp Leu Glu Arg Glu Glu Phe Leu Val
         235                 240                 245

 ccc aag aat gtg ctg gac atc gtg gcg ggg cag acg gtc acc tgg atg     1239
 Pro Lys Asn Val Leu Asp Ile Val Ala Gly Gln Thr Val Thr Trp Met
     250                 255                 260

 ggc ctc ttc tac tgc ccc ctg ctg ccc ctg ctg aat agc gtc ttc ctc     1287
 Gly Leu Phe Tyr Cys Pro Leu Leu Pro Leu Leu Asn Ser Val Phe Leu
 265                 270                 275                 280

 ttc ctc acc ttc tac atc aag aag tac acc ctc ctg aag aac tcc agg     1335
 Phe Leu Thr Phe Tyr Ile Lys Lys Tyr Thr Leu Leu Lys Asn Ser Arg
                 285                 290                 295

 gca tct tcg cgg ccc ttc cgt gcc tcc agc tcc acc ttc ttc ttc cag     1383
 Ala Ser Ser Arg Pro Phe Arg Ala Ser Ser Ser Thr Phe Phe Phe Gln
             300                 305                 310

 cta gtg ctc ctc ctg ggc ctg ctt ctg gct gca gtg ccc ctg ggc tat     1431
 Leu Val Leu Leu Leu Gly Leu Leu Leu Ala Ala Val Pro Leu Gly Tyr
         315                 320                 325

 gtg gtc agc agc atc cac tcc tcc tgg gac tgc ggc ctc ttc acc aac     1479
 Val Val Ser Ser Ile His Ser Ser Trp Asp Cys Gly Leu Phe Thr Asn
     330                 335                 340

 tac tca gca ccc tgg caa gtg gtc ccg gag ctg gtg gcc ctt ggg ctc     1527
 Tyr Ser Ala Pro Trp Gln Val Val Pro Glu Leu Val Ala Leu Gly Leu
 345                 350                 355                 360

 ccg ccc att ggc cag cgt gcc ctc cac tac ctg ggc tcc cac gcc ttc     1575
 Pro Pro Ile Gly Gln Arg Ala Leu His Tyr Leu Gly Ser His Ala Phe
                 365                 370                 375

 agc ttc ccc ctc ctc atc atg ctc agc ctt gtc ctg acg gtg tgc gtc     1623
 Ser Phe Pro Leu Leu Ile Met Leu Ser Leu Val Leu Thr Val Cys Val
             380                 385                 390

 tcc cag acc cag gcc aat gcc agg gcc atc cac agg ctc cgg aag cag     1671
 Ser Gln Thr Gln Ala Asn Ala Arg Ala Ile His Arg Leu Arg Lys Gln
         395                 400                 405

 ctg gtg tgg gtt cag gag aag tgg cac ctg gtg gag gac ctg tcg cga     1719
 Leu Val Trp Val Gln Glu Lys Trp His Leu Val Glu Asp Leu Ser Arg
     410                 415                 420

 ctg ctg ccg gag cca ggc ccg agc gac tct ccg ggc ccc aag tac cct     1767
 Leu Leu Pro Glu Pro Gly Pro Ser Asp Ser Pro Gly Pro Lys Tyr Pro
 425                 430                 435                 440

 gcc tcc caa gct tcg cgc ccg cag tcc ttc tgc ccc gga tgc cca tgc     1815
 Ala Ser Gln Ala Ser Arg Pro Gln Ser Phe Cys Pro Gly Cys Pro Cys
                 445                 450                 455

 cct ggc tcc ccg ggc cac cac ggc ccc gcg gcg ggc ccc tcc gtc gtg     1863
 Pro Gly Ser Pro Gly His His Gly Pro Ala Ala Gly Pro Ser Val Val
             460                 465                 470

 gat gcc gcg gga ctg cgt tcc cct tgc cct gga cag cac ggt gcc ccg     1911
 Asp Ala Ala Gly Leu Arg Ser Pro Cys Pro Gly Gln His Gly Ala Pro
         475                 480                 485

 gct ccg ccg cag att ccg ctt ccc cca gcg gcg cgg agc ttg taa acc     1959
 Ala Pro Pro Gln Ile Pro Leu Pro Pro Ala Ala Arg Ser Leu 
     490                 495                 500

 ccgaccctgc tcccgaagcc tccctggggc ccttaggcct cttactccat ttcagaccct   2019

 gggacacggc cctctagtgg tcagggctcc tcagaggt                           2057




      <210> 247
      <211> 1766
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (332)..(1195)

      <400> 247
 gtgcgccctt gcttcgtgcc ctcaacccgc atggcggagc cgctggcgcg ccgcggagag     60

 cgccgggcga gtcgggcggt ttcggcgccc gcgctgagcc gcggaggagg ggcggaggac    120

 gcccctgcag ccggtgcgtc tgccctcagt gaggcggggc gcgcggcgga cgcccccggg    180

 caggggcggg agtggtggag gcgccggcgg ttggcactga caggggcggt gagcgagccg    240

 ctccggtctc cgggcgaggc ttggccttcc gagcagagac ggcgggaagc ggcggcggca    300

 gcggccggcc ctagggccgg ctggtgaggc g   atg gcg gcg ccg gcc ccg ggg     352
                                      Met Ala Ala Pro Ala Pro Gly
                                        1               5

 gct ggg gca gcc tcg ggc ggc gct ggc tgt agc ggc ggc ggc gcg ggc      400
 Ala Gly Ala Ala Ser Gly Gly Ala Gly Cys Ser Gly Gly Gly Ala Gly
          10                  15                  20

 gcg ggc gcg ggc tcg ggc tct ggg gcc gcg ggg gcc ggg gga ccc ggc      448
 Ala Gly Ala Gly Ser Gly Ser Gly Ala Ala Gly Ala Gly Gly Pro Gly
      25                  30                  35

 tgc cca gcc ggg tgc tgg atg ttg gtg ttc tct tac ctg gag ctg tcc      496
 Cys Pro Ala Gly Cys Trp Met Leu Val Phe Ser Tyr Leu Glu Leu Ser
  40                  45                  50                  55

 gag ctg cgg agc tgc gcc ctg gtg tgc aag cac tgg tac cgc tgc ctg      544
 Glu Leu Arg Ser Cys Ala Leu Val Cys Lys His Trp Tyr Arg Cys Leu
                  60                  65                  70

 cac ggc gat gag aac agc gag gtg tgg cgg agc ctg tgc gcc cgc agc      592
 His Gly Asp Glu Asn Ser Glu Val Trp Arg Ser Leu Cys Ala Arg Ser
              75                  80                  85

 ctg gca gaa gag gct ctg cgc acg gac atc ctg tgc aac ctg ccc agc      640
 Leu Ala Glu Glu Ala Leu Arg Thr Asp Ile Leu Cys Asn Leu Pro Ser
          90                  95                 100

 tac aag gcc aag ata cgt gct ttt caa cat gcc ttc agc act aat gac      688
 Tyr Lys Ala Lys Ile Arg Ala Phe Gln His Ala Phe Ser Thr Asn Asp
     105                 110                 115

 tgc tcc agg aat gtc tac att aag aag aat ggc ttt act tta cat cga      736
 Cys Ser Arg Asn Val Tyr Ile Lys Lys Asn Gly Phe Thr Leu His Arg
 120                 125                 130                 135

 aac ccc att gct cag agc act gat ggt gca agg acc aag att ggt ttc      784
 Asn Pro Ile Ala Gln Ser Thr Asp Gly Ala Arg Thr Lys Ile Gly Phe
                 140                 145                 150

 agt gag ggc cgc cat gca tgg gaa gtg tgg tgg gag ggc cct ctg ggc      832
 Ser Glu Gly Arg His Ala Trp Glu Val Trp Trp Glu Gly Pro Leu Gly
             155                 160                 165

 act gtg gca gtg att gga att gcc aca aaa cgg gcc ccc atg cag tgc      880
 Thr Val Ala Val Ile Gly Ile Ala Thr Lys Arg Ala Pro Met Gln Cys
         170                 175                 180

 caa ggt tat gtg gca ttg ctg ggc agt gat gac cag agc tgg ggc tgg      928
 Gln Gly Tyr Val Ala Leu Leu Gly Ser Asp Asp Gln Ser Trp Gly Trp
     185                 190                 195

 aat ctg gtg gac aat aat cta cta cat aat gga gaa gtc aat ggc agt      976
 Asn Leu Val Asp Asn Asn Leu Leu His Asn Gly Glu Val Asn Gly Ser
 200                 205                 210                 215

 ttt cca cag tgc aac aac gca cca aaa tat cag ata gga gaa aga att     1024
 Phe Pro Gln Cys Asn Asn Ala Pro Lys Tyr Gln Ile Gly Glu Arg Ile
                 220                 225                 230

 cga gtc atc ttg gac atg gaa gat aag act tta gct ttt gaa cgt gga     1072
 Arg Val Ile Leu Asp Met Glu Asp Lys Thr Leu Ala Phe Glu Arg Gly
             235                 240                 245

 tat gag ttc ctg ggg gtt gct ttt aga gga ctt cca aag gtc tgc tta     1120
 Tyr Glu Phe Leu Gly Val Ala Phe Arg Gly Leu Pro Lys Val Cys Leu
         250                 255                 260

 tac cca gca gtt tct gct gta tat ggc aac aca gaa gtg act ttg gtt     1168
 Tyr Pro Ala Val Ser Ala Val Tyr Gly Asn Thr Glu Val Thr Leu Val
     265                 270                 275

 tac ctt gga aaa cct ttg gac gga tga cagtg gctttcttgt gatgacagac     1220
 Tyr Leu Gly Lys Pro Leu Asp Gly 
 280                 285

 agaatggagg agagatctgc ttatgggaag tagaaccatg aagtgactgt cacacatgca   1280

 tgtccaagaa acatcctgaa aacacatgaa gtcgtaaact ggagaagcag ctctacagca   1340

 gagattatct tcgtgtttcc tctttctact gggccagaaa aatcctcagg gttgcagttg   1400

 gttgagtggg cagttgacat atgcatgttg cacccgatgt tgtctctaag ttagcaatgt   1460

 gttatttcca gctttaaagg tgagattgta gagatgctgt caaagggata aggaaatagc   1520

 aagattttta agtagtgtgt ttgtgaagac tgatcccatt ttacaactgc ctgttctttc   1580

 tccagtcctt ttttttccag ccagcttgac tattagaaaa gtatgaaact ggttgggttt   1640

 tatttaatat ttttaatata ttgagaagca tggtctgcct ggactgcact tctctaaaag   1700

 tgagatataa aattgtgcag ctattttaaa agttgtatat aatatgtgtg taaaaaaaaa   1760

 aaaaaa                                                              1766




      <210> 248
      <211> 1229
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1170)

      <400> 248
  atg ggg ttc atg gat gac aat gcc acc aac act tcc acc agc ttc ctt      48
  Met Gly Phe Met Asp Asp Asn Ala Thr Asn Thr Ser Thr Ser Phe Leu
    1               5                  10                  15

 tct gtg ctc aac cct cat gga gcc cat gcc act tcc ttc cca ttc aac       96
 Ser Val Leu Asn Pro His Gly Ala His Ala Thr Ser Phe Pro Phe Asn
              20                  25                  30

 ttc agc tac agc gac tat gat atg cct ttg gat gaa gat gag gat gtg      144
 Phe Ser Tyr Ser Asp Tyr Asp Met Pro Leu Asp Glu Asp Glu Asp Val
          35                  40                  45

 acc aat tcc agg acg ttc ttt gct gcc aag att gtc att ggg atg gcc      192
 Thr Asn Ser Arg Thr Phe Phe Ala Ala Lys Ile Val Ile Gly Met Ala
      50                  55                  60

 ctg gtg ggc atc atg ctg gtc tgc ggc att gga aac ttc atc ttt atc      240
 Leu Val Gly Ile Met Leu Val Cys Gly Ile Gly Asn Phe Ile Phe Ile
  65                  70                  75                  80

 gct gcc ctg gtc cgc tac aag aaa ctg cgc aac ctc acc aac ctg ctc      288
 Ala Ala Leu Val Arg Tyr Lys Lys Leu Arg Asn Leu Thr Asn Leu Leu
                  85                  90                  95

 atc gcc aac ctg gcc atc tct gac ttc ctg gtg gcc att gtc tgc tgc      336
 Ile Ala Asn Leu Ala Ile Ser Asp Phe Leu Val Ala Ile Val Cys Cys
             100                 105                 110

 ccc ttt gag atg gac tac tat gtg gtg cgc cag ctc tcc tgg gag cac      384
 Pro Phe Glu Met Asp Tyr Tyr Val Val Arg Gln Leu Ser Trp Glu His
         115                 120                 125

 ggc cac gtc ctg tgc acc tct gtc aac tac ctg cgc act gtc tct ctc      432
 Gly His Val Leu Cys Thr Ser Val Asn Tyr Leu Arg Thr Val Ser Leu
     130                 135                 140

 tat gtc tcc acc aat gcc ctg ctg gcc atc gcc att gac aga tat ctc      480
 Tyr Val Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile Asp Arg Tyr Leu
 145                 150                 155                 160

 gcc atc gtt cac ccc ttg aaa cca cgg atg aat tat caa acg gcc tcc      528
 Ala Ile Val His Pro Leu Lys Pro Arg Met Asn Tyr Gln Thr Ala Ser
                 165                 170                 175

 ttc ctg atc gcc ttg gtc tgg atg gtg tcc att ctc att gcc atc cca      576
 Phe Leu Ile Ala Leu Val Trp Met Val Ser Ile Leu Ile Ala Ile Pro
             180                 185                 190

 tcg gct tac ttt gca aca gaa acg gtc ctc ttt att gtc aag agc cag      624
 Ser Ala Tyr Phe Ala Thr Glu Thr Val Leu Phe Ile Val Lys Ser Gln
         195                 200                 205

 gag aag atc ttc tgt ggc cag atc tgg cct gtg gat cag cag ctc tac      672
 Glu Lys Ile Phe Cys Gly Gln Ile Trp Pro Val Asp Gln Gln Leu Tyr
     210                 215                 220

 tac aag tcc tac ttc ctc ttc atc ttt ggt gtc gag ttc gtg ggc cct      720
 Tyr Lys Ser Tyr Phe Leu Phe Ile Phe Gly Val Glu Phe Val Gly Pro
 225                 230                 235                 240

 gtg gtc acc atg acc ctg tgc tat gcc agg atc tcc cgg gag ctc tgg      768
 Val Val Thr Met Thr Leu Cys Tyr Ala Arg Ile Ser Arg Glu Leu Trp
                 245                 250                 255

 ttc aag gca gtc cct ggg ttc cag acg gag cag att cgc aag cgg ctg      816
 Phe Lys Ala Val Pro Gly Phe Gln Thr Glu Gln Ile Arg Lys Arg Leu
             260                 265                 270

 cgc tgc cgc agg aag acg gtc ctg gtg ctc atg tgc att ctc acg gcc      864
 Arg Cys Arg Arg Lys Thr Val Leu Val Leu Met Cys Ile Leu Thr Ala
         275                 280                 285

 tat gtg ctg tgc tgg gca ccc ttc tac ggt ttc acc atc gtt cgt gac      912
 Tyr Val Leu Cys Trp Ala Pro Phe Tyr Gly Phe Thr Ile Val Arg Asp
     290                 295                 300

 ttc ttc ccc act gtg ttc gtg aag gaa aag cac tac ctc act gcc ttc      960
 Phe Phe Pro Thr Val Phe Val Lys Glu Lys His Tyr Leu Thr Ala Phe
 305                 310                 315                 320

 tac gtg gtc gag tgc atc gcc atg agc aac agc atg atc aac acc gtg     1008
 Tyr Val Val Glu Cys Ile Ala Met Ser Asn Ser Met Ile Asn Thr Val
                 325                 330                 335

 tgc ttc gtg acg gtc aag aac aac acc atg aag tac ttc aag aag atg     1056
 Cys Phe Val Thr Val Lys Asn Asn Thr Met Lys Tyr Phe Lys Lys Met
             340                 345                 350

 atg ctg ctg cac tgg cgt ccc tcc cag cgg ggg agc aag tcc agt gct     1104
 Met Leu Leu His Trp Arg Pro Ser Gln Arg Gly Ser Lys Ser Ser Ala
         355                 360                 365

 gac ctt gac ctc aga acc aac ggg gtg ccc acc aca gaa gag gtg gac     1152
 Asp Leu Asp Leu Arg Thr Asn Gly Val Pro Thr Thr Glu Glu Val Asp
     370                 375                 380

 tgt atc agg ctg aag tga cccact ggtgtcacac aattgaaaac cccagtccag     1206
 Cys Ile Arg Leu Lys 
 385

 tactcagagc atcacccacc atc                                           1229




      <210> 249
      <211> 1111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(1057)

      <400> 249
 c    atg acc tgg agc gcc acg gcc cgg ggc gcc cac cag ccc gac aac      46
      Met Thr Trp Ser Ala Thr Ala Arg Gly Ala His Gln Pro Asp Asn
        1               5                  10                  15

 acc gcc ttc act cag cag cgc ctc ccc gcc tgg cag ccg ctg ctg tcg       94
 Thr Ala Phe Thr Gln Gln Arg Leu Pro Ala Trp Gln Pro Leu Leu Ser
                  20                  25                  30

 gcc agc atc gcg ctg ccg ctc ttc ttc tgc gcg ggc ctg gcc ttc atc      142
 Ala Ser Ile Ala Leu Pro Leu Phe Phe Cys Ala Gly Leu Ala Phe Ile
              35                  40                  45

 ggc ctg ggc ctg ggc cac tac tac tcc tcc aac ggc atc aag gag ctg      190
 Gly Leu Gly Leu Gly His Tyr Tyr Ser Ser Asn Gly Ile Lys Glu Leu
          50                  55                  60

 gag tac gac tat aca ggc gac ccg ggc acc ggc aac tgc tcg gtg tgc      238
 Glu Tyr Asp Tyr Thr Gly Asp Pro Gly Thr Gly Asn Cys Ser Val Cys
      65                  70                  75

 gcc gcg gct ggc cag ggc cgg gcg ctg ccg ccc ccc tgc tcg tgc gcc      286
 Ala Ala Ala Gly Gln Gly Arg Ala Leu Pro Pro Pro Cys Ser Cys Ala
  80                  85                  90                  95

 tgg tac ttc tcg ctg ccc gag ctc ttc cag ggc cca gtg tac ctc tac      334
 Trp Tyr Phe Ser Leu Pro Glu Leu Phe Gln Gly Pro Val Tyr Leu Tyr
                 100                 105                 110

 tac gag ctg acc aac ttc tac cag aac aac cgg cgc tac ggc gtg tcc      382
 Tyr Glu Leu Thr Asn Phe Tyr Gln Asn Asn Arg Arg Tyr Gly Val Ser
             115                 120                 125

 cgc gac gac gcg cag ctg agc gga ctc ccc agc gcg ctg cgc cac cct      430
 Arg Asp Asp Ala Gln Leu Ser Gly Leu Pro Ser Ala Leu Arg His Pro
         130                 135                 140

 gtc aac gag tgc gcc ccc tac cag cgc agc gcg gcc ggc ctg ccc atc      478
 Val Asn Glu Cys Ala Pro Tyr Gln Arg Ser Ala Ala Gly Leu Pro Ile
     145                 150                 155

 gcg ccc tgc ggc gcc atc gcc aac agc ctc ttc aac gac tcc ttc tcg      526
 Ala Pro Cys Gly Ala Ile Ala Asn Ser Leu Phe Asn Asp Ser Phe Ser
 160                 165                 170                 175

 ctt tgg cac cag cgc cag ccc ggc ggg ccc tac gtc gag gtg ccg ctc      574
 Leu Trp His Gln Arg Gln Pro Gly Gly Pro Tyr Val Glu Val Pro Leu
                 180                 185                 190

 gac cgc tcc ggc atc gcc tgg tgg acc gac tac cac gtc aag ttc cgc      622
 Asp Arg Ser Gly Ile Ala Trp Trp Thr Asp Tyr His Val Lys Phe Arg
             195                 200                 205

 aac ccg ccg ctg gtc aac ggc agc ctg gcg ttg gcc ttc cag ggc acg      670
 Asn Pro Pro Leu Val Asn Gly Ser Leu Ala Leu Ala Phe Gln Gly Thr
         210                 215                 220

 gcg ccc ccg ccc aac tgg cgc cgg cca gtc tac gag ctc agc ccc gac      718
 Ala Pro Pro Pro Asn Trp Arg Arg Pro Val Tyr Glu Leu Ser Pro Asp
     225                 230                 235

 ccc aac aac acc ggc ttc atc aat cag gac ttc gtg gtg tgg atg cgc      766
 Pro Asn Asn Thr Gly Phe Ile Asn Gln Asp Phe Val Val Trp Met Arg
 240                 245                 250                 255

 acg gcg gcg ctg ccc acg ttc cgc aaa ctg tac gcg cgc atc cgc cag      814
 Thr Ala Ala Leu Pro Thr Phe Arg Lys Leu Tyr Ala Arg Ile Arg Gln
                 260                 265                 270

 ggc aac tac tcg gcc ggg ctg ccg cgg ggc gcc tac cgc gtc aac atc      862
 Gly Asn Tyr Ser Ala Gly Leu Pro Arg Gly Ala Tyr Arg Val Asn Ile
             275                 280                 285

 acc tac aac tac ccg gtg cgc gcg ttc ggc ggc cac aag ctc ctc atc      910
 Thr Tyr Asn Tyr Pro Val Arg Ala Phe Gly Gly His Lys Leu Leu Ile
         290                 295                 300

 ttc agc agc atc tcg tgg atg ggt ggc aag aac ccc ttc ctg ggc atc      958
 Phe Ser Ser Ile Ser Trp Met Gly Gly Lys Asn Pro Phe Leu Gly Ile
     305                 310                 315

 gcc tac ctg gtc gtc ggc tcc ctc tgc atc ctc acc ggc ttt gtc atg     1006
 Ala Tyr Leu Val Val Gly Ser Leu Cys Ile Leu Thr Gly Phe Val Met
 320                 325                 330                 335

 ctg gtc gtc tac att cgc tac cag gac cag gac gac gac gac gag gag     1054
 Leu Val Val Tyr Ile Arg Tyr Gln Asp Gln Asp Asp Asp Asp Glu Glu
                 340                 345                 350

 tga ttcc ggctttccag ggatccctcc tgcttcttgc caaaactctt gcaaggtgct     1111
 






      <210> 250
      <211> 1170
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1170)

      <400> 250
  atg gca gtt tat aat aag aaa gag gac ttg gga caa gtg atg tgc tac      48
  Met Ala Val Tyr Asn Lys Lys Glu Asp Leu Gly Gln Val Met Cys Tyr
    1               5                  10                  15

 tta ctt tac ttt cat caa tta gga gtc aat cct act agg cca ata gcc       96
 Leu Leu Tyr Phe His Gln Leu Gly Val Asn Pro Thr Arg Pro Ile Ala
              20                  25                  30

 aaa gga aat ggt gac ttc cca agt atg cct ggc cac aat acc tcc agg      144
 Lys Gly Asn Gly Asp Phe Pro Ser Met Pro Gly His Asn Thr Ser Arg
          35                  40                  45

 aat tcc tct tgc gat cct ata gtg aca ccc cac tta atc agc ctc tac      192
 Asn Ser Ser Cys Asp Pro Ile Val Thr Pro His Leu Ile Ser Leu Tyr
      50                  55                  60

 ttc ata gtg ctt att ggc ggg ctg gtg ggt gtc att tcc att ctt ttc      240
 Phe Ile Val Leu Ile Gly Gly Leu Val Gly Val Ile Ser Ile Leu Phe
  65                  70                  75                  80

 ctc ctg gtg aaa atg aac acc cgg tca gtg acc acc atg gcg gtc att      288
 Leu Leu Val Lys Met Asn Thr Arg Ser Val Thr Thr Met Ala Val Ile
                  85                  90                  95

 aac ttg gtg gtg gtc cac agc gtt ttt ctg ctg aca gtg cca ttt cgc      336
 Asn Leu Val Val Val His Ser Val Phe Leu Leu Thr Val Pro Phe Arg
             100                 105                 110

 ttg acc tac ctc atc aag aag act tgg atg ttt ggg ctg ccc ttc tgc      384
 Leu Thr Tyr Leu Ile Lys Lys Thr Trp Met Phe Gly Leu Pro Phe Cys
         115                 120                 125

 aaa ttt gtg agt gcc atg ctg cac atc cac atg tac ctc acg ttc cta      432
 Lys Phe Val Ser Ala Met Leu His Ile His Met Tyr Leu Thr Phe Leu
     130                 135                 140

 ttc tat gtg gtg atc ctg gtc acc aga tac ctc atc ttc ttc aag tgc      480
 Phe Tyr Val Val Ile Leu Val Thr Arg Tyr Leu Ile Phe Phe Lys Cys
 145                 150                 155                 160

 aaa gac aaa gtg gaa ttc tac aga aaa ctg cat gct gtg gct gcc agt      528
 Lys Asp Lys Val Glu Phe Tyr Arg Lys Leu His Ala Val Ala Ala Ser
                 165                 170                 175

 gct ggc atg tgg acg ctg gtg att gtc att gtg gta ccc ctg gtt gtc      576
 Ala Gly Met Trp Thr Leu Val Ile Val Ile Val Val Pro Leu Val Val
             180                 185                 190

 tcc cgg tat gga atc cat gag gaa tac aat gag gag cac tgt ttt aaa      624
 Ser Arg Tyr Gly Ile His Glu Glu Tyr Asn Glu Glu His Cys Phe Lys
         195                 200                 205

 ttt cac aaa gag ctt gct tac aca tat gtg aaa atc atc aac tat atg      672
 Phe His Lys Glu Leu Ala Tyr Thr Tyr Val Lys Ile Ile Asn Tyr Met
     210                 215                 220

 ata gtc att ttt gtc ata gcc gtt gct gtg att ctg ttg gtc ttc cag      720
 Ile Val Ile Phe Val Ile Ala Val Ala Val Ile Leu Leu Val Phe Gln
 225                 230                 235                 240

 gtc ttc atc att atg ttg atg ccc acc tca cat aca cac aca ccc agc      768
 Val Phe Ile Ile Met Leu Met Pro Thr Ser His Thr His Thr Pro Ser
                 245                 250                 255

 act gaa atg cag acc ttg cag gaa agg gtg ggt ccc ctg gat gat gga      816
 Thr Glu Met Gln Thr Leu Gln Glu Arg Val Gly Pro Leu Asp Asp Gly
             260                 265                 270

 gaa gtt cac aaa ggt gct ttg ctg atg gaa ctt gct gaa aag cca ctc      864
 Glu Val His Lys Gly Ala Leu Leu Met Glu Leu Ala Glu Lys Pro Leu
         275                 280                 285

 ata ggg gta tta gaa aaa gct gtc caa ggg gag aaa ctg cat ctc agg      912
 Ile Gly Val Leu Glu Lys Ala Val Gln Gly Glu Lys Leu His Leu Arg
     290                 295                 300

 cca tgc tgg gca tct gcc caa gga acc gaa tgc ctt tgg aag ctg ctc      960
 Pro Cys Trp Ala Ser Ala Gln Gly Thr Glu Cys Leu Trp Lys Leu Leu
 305                 310                 315                 320

 tct gaa ggg cag gga tgg ctg tcc acg agg agg cca cat gca ttg cgt     1008
 Ser Glu Gly Gln Gly Trp Leu Ser Thr Arg Arg Pro His Ala Leu Arg
                 325                 330                 335

 gca tta ggc agg agc ctg cta cga gaa agc agg tac cag agc cag gga     1056
 Ala Leu Gly Arg Ser Leu Leu Arg Glu Ser Arg Tyr Gln Ser Gln Gly
             340                 345                 350

 gaa aag cct att ctt ccc caa gtg ctg ctt cag cgc ctt gta atg atg     1104
 Glu Lys Pro Ile Leu Pro Gln Val Leu Leu Gln Arg Leu Val Met Met
         355                 360                 365

 aag att agt tta gca tcc cac cca ttg gta agg gag aaa cgt gct agt     1152
 Lys Ile Ser Leu Ala Ser His Pro Leu Val Arg Glu Lys Arg Ala Ser
     370                 375                 380

 ttc atg gca ggg cag tag                                             1170
 Phe Met Ala Gly Gln 
 385





      <210> 251
      <211> 1903
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (386)..(1903)

      <400> 251
 gtggaattgg aagtccaggc tccctgctca acctttgcca gcagcacagg ggaacagagg     60

 gcattctgtt cagaaaaaaa tccagctgtg gaatgttttt atttcatctt cattgggaag    120

 aaaggccaca aaacattcag ggatgcccct taaaacttgt cctttgaagc attatgcttt    180

 tatcaagcat ctgtgctaca gctttgaaga tttttctctt gaatcatatt tagtagaaat    240

 caaagctgtg cataatctaa gtttgcaaag tcatggaact aaaggagtgt ttgagcttct    300

 gtccggatgg cggagaacca aagagaactt gcccttcaaa gacaggatag cagatgccta    360

 ttctgatgtg atggtcacct atacc  atg acc agc tcc ctg tac ttc atc act     412
                              Met Thr Ser Ser Leu Tyr Phe Ile Thr
                                1               5

 ttt ggc atg ggt gcc agc cca ttc aca aac ata gag gct gtg aag gtc      460
 Phe Gly Met Gly Ala Ser Pro Phe Thr Asn Ile Glu Ala Val Lys Val
  10                  15                  20                  25

 ttc tgt caa aac atg tgt gtc tct att ctg ttg aac tac ttc tac att      508
 Phe Cys Gln Asn Met Cys Val Ser Ile Leu Leu Asn Tyr Phe Tyr Ile
                  30                  35                  40

 ttc tcc ttc ttt ggc tcc tgt ctg gtc ttt gct ggc caa cta gag caa      556
 Phe Ser Phe Phe Gly Ser Cys Leu Val Phe Ala Gly Gln Leu Glu Gln
              45                  50                  55

 aac cgc tac cac agc atc ttt tgc tgt aag atc cct tct gca gaa tac      604
 Asn Arg Tyr His Ser Ile Phe Cys Cys Lys Ile Pro Ser Ala Glu Tyr
          60                  65                  70

 ctg gat cgc aaa cct gtg tgg ttc cag aca gtg atg agt gat ggg cat      652
 Leu Asp Arg Lys Pro Val Trp Phe Gln Thr Val Met Ser Asp Gly His
      75                  80                  85

 caa cag acg tcc cat cat gag acg aac ccc tac cag cac cac ttc att      700
 Gln Gln Thr Ser His His Glu Thr Asn Pro Tyr Gln His His Phe Ile
  90                  95                 100                 105

 cag cac ttc ctc cgt gaa cat tat aat gaa tgg att acc aat ata tat      748
 Gln His Phe Leu Arg Glu His Tyr Asn Glu Trp Ile Thr Asn Ile Tyr
                 110                 115                 120

 gtg aag cca ttt gtt gtc atc ctc tat ctc att tat gcc tcc ttc tcc      796
 Val Lys Pro Phe Val Val Ile Leu Tyr Leu Ile Tyr Ala Ser Phe Ser
             125                 130                 135

 ttc atg ggg tgc tta cag atc agt gac gga gcc aac atc atc aat cta      844
 Phe Met Gly Cys Leu Gln Ile Ser Asp Gly Ala Asn Ile Ile Asn Leu
         140                 145                 150

 cta gcc agt gat tcg cca agt gtt tcc tat gcc atg gtt cag cag aaa      892
 Leu Ala Ser Asp Ser Pro Ser Val Ser Tyr Ala Met Val Gln Gln Lys
     155                 160                 165

 tat ttc agc aac tat agc cct gtg ata gga ttc tac gtc tat gag ccc      940
 Tyr Phe Ser Asn Tyr Ser Pro Val Ile Gly Phe Tyr Val Tyr Glu Pro
 170                 175                 180                 185

 cta gag tac tgg aac agc agc gtc cag gat gac cta aga aga ctc tgt      988
 Leu Glu Tyr Trp Asn Ser Ser Val Gln Asp Asp Leu Arg Arg Leu Cys
                 190                 195                 200

 agt gga ttc act gca gtg tcc tgg gtg gag cag tac tac cag ttc ctg     1036
 Ser Gly Phe Thr Ala Val Ser Trp Val Glu Gln Tyr Tyr Gln Phe Leu
             205                 210                 215

 aaa gtc agc aac gtc agt gcc aat aac aaa agt gac ttc atc agt gtc     1084
 Lys Val Ser Asn Val Ser Ala Asn Asn Lys Ser Asp Phe Ile Ser Val
         220                 225                 230

 ctg caa agc tca ttt tta aaa aag cca gaa ttc cag cat ttt cga aat     1132
 Leu Gln Ser Ser Phe Leu Lys Lys Pro Glu Phe Gln His Phe Arg Asn
     235                 240                 245

 gat atc atc ttc tcc aag gca ggg gat gaa agc aat atc att gct tct     1180
 Asp Ile Ile Phe Ser Lys Ala Gly Asp Glu Ser Asn Ile Ile Ala Ser
 250                 255                 260                 265

 cgc ttg tat ctg gtg gcc agg act agc aga gac aag cag aaa gaa atc     1228
 Arg Leu Tyr Leu Val Ala Arg Thr Ser Arg Asp Lys Gln Lys Glu Ile
                 270                 275                 280

 aca gaa gtg ttg gaa aag ctg agg ccc cta tcc ctc tca aag agc atc     1276
 Thr Glu Val Leu Glu Lys Leu Arg Pro Leu Ser Leu Ser Lys Ser Ile
             285                 290                 295

 cga ttc atc gtg ttc aac ccc tcc ttt gtc ttc atg gac cat tac agc     1324
 Arg Phe Ile Val Phe Asn Pro Ser Phe Val Phe Met Asp His Tyr Ser
         300                 305                 310

 ttg tct gtc aca gtg cct gtt ctg att gca ggc ttt ggt gtt ctc ctg     1372
 Leu Ser Val Thr Val Pro Val Leu Ile Ala Gly Phe Gly Val Leu Leu
     315                 320                 325

 gtg tta atc ctg act ttt ttc cta gtg atc cac cct ctg gga aac ttc     1420
 Val Leu Ile Leu Thr Phe Phe Leu Val Ile His Pro Leu Gly Asn Phe
 330                 335                 340                 345

 tgg cta att ctt agc gtc acc tca att gag ctg ggc gtt ctg ggc tta     1468
 Trp Leu Ile Leu Ser Val Thr Ser Ile Glu Leu Gly Val Leu Gly Leu
                 350                 355                 360

 atg aca tta tgg aac gtc gac atg gat tgc att tct atc ttg tgc ctt     1516
 Met Thr Leu Trp Asn Val Asp Met Asp Cys Ile Ser Ile Leu Cys Leu
             365                 370                 375

 atc tac acc ttg aat ttc gcc att gac cac tgt gca cca ctg ctt ttc     1564
 Ile Tyr Thr Leu Asn Phe Ala Ile Asp His Cys Ala Pro Leu Leu Phe
         380                 385                 390

 aca ttt gta tta gca act gag cac acc cga aca caa tgt ata aaa agc     1612
 Thr Phe Val Leu Ala Thr Glu His Thr Arg Thr Gln Cys Ile Lys Ser
     395                 400                 405

 tcc ttg caa gac cat ggg aca gcc att ttg caa aat gtt act tct ttt     1660
 Ser Leu Gln Asp His Gly Thr Ala Ile Leu Gln Asn Val Thr Ser Phe
 410                 415                 420                 425

 ctt att ggg tta gtc ccc ctt cta ttt gtg cct tcg aac ctg acc ttc     1708
 Leu Ile Gly Leu Val Pro Leu Leu Phe Val Pro Ser Asn Leu Thr Phe
                 430                 435                 440

 aca ctg ttc aaa tgc ttg ctg ctc act ggg ggt tgc aca ctt ctg cac     1756
 Thr Leu Phe Lys Cys Leu Leu Leu Thr Gly Gly Cys Thr Leu Leu His
             445                 450                 455

 tgt ttt gtt att tta cct gtg ttc cta acg ttt ttc ccc cct tcc aaa     1804
 Cys Phe Val Ile Leu Pro Val Phe Leu Thr Phe Phe Pro Pro Ser Lys
         460                 465                 470

 aag cac cac aag aaa aag aaa cgt gcc aag cga aag gag aga gag gaa     1852
 Lys His His Lys Lys Lys Lys Arg Ala Lys Arg Lys Glu Arg Glu Glu
     475                 480                 485

 att gaa tgc ata gaa att caa gag aac ccg gat cac gtc acc aca gta     1900
 Ile Glu Cys Ile Glu Ile Gln Glu Asn Pro Asp His Val Thr Thr Val
 490                 495                 500                 505

 tga                                                                 1903
 






      <210> 252
      <211> 2186
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (39)..(1796)

      <400> 252
 cacgagactt agacaaaaaa agacatgcag agctgaag    atg gat cag gct ttg      53
                                              Met Asp Gln Ala Leu
                                                1               5

 cta ctc atc cat aat gaa ctt ctc tgg acc aac ttg acc gtc tac tgg      101
 Leu Leu Ile His Asn Glu Leu Leu Trp Thr Asn Leu Thr Val Tyr Trp
                  10                  15                  20

 aaa tct gaa tgc tgt tat cac tgc ttg ttt cag gtt ctg gta aac gtt      149
 Lys Ser Glu Cys Cys Tyr His Cys Leu Phe Gln Val Leu Val Asn Val
              25                  30                  35

 cct cag agt cca aaa gca ggg aag cct agt gct gca gct gcc tct gtc      197
 Pro Gln Ser Pro Lys Ala Gly Lys Pro Ser Ala Ala Ala Ala Ser Val
          40                  45                  50

 agc acc cag cac gga tct atc ctg cag ctg aac gac acc ttg gaa gag      245
 Ser Thr Gln His Gly Ser Ile Leu Gln Leu Asn Asp Thr Leu Glu Glu
      55                  60                  65

 aaa gaa gtt tgt agg ttg gaa tac aga ttt gga gaa ttt gga aac tat      293
 Lys Glu Val Cys Arg Leu Glu Tyr Arg Phe Gly Glu Phe Gly Asn Tyr
  70                  75                  80                  85

 tct ctc ttg gta aag aac atc cat aat gga gtt agt gaa att gcc tgt      341
 Ser Leu Leu Val Lys Asn Ile His Asn Gly Val Ser Glu Ile Ala Cys
                  90                  95                 100

 gac ctg gct gtg aac gag gat cca gtt gat agt aac ctt cct gtg agc      389
 Asp Leu Ala Val Asn Glu Asp Pro Val Asp Ser Asn Leu Pro Val Ser
             105                 110                 115

 att gca ttc ctt att ggt ctt gct gtc atc att gtg ata tcc ttt ctg      437
 Ile Ala Phe Leu Ile Gly Leu Ala Val Ile Ile Val Ile Ser Phe Leu
         120                 125                 130

 agg ctc ttg ttg agt ttg gat gac ttt aac aat tgg att tct aaa gcc      485
 Arg Leu Leu Leu Ser Leu Asp Asp Phe Asn Asn Trp Ile Ser Lys Ala
     135                 140                 145

 ata agt tct cga gaa act gat cgc ctc atc aat tct gag ctg gga tct      533
 Ile Ser Ser Arg Glu Thr Asp Arg Leu Ile Asn Ser Glu Leu Gly Ser
 150                 155                 160                 165

 ccc agc agg aca gac cct ctc gat ggt gat gtt cag cca gca acg tgg      581
 Pro Ser Arg Thr Asp Pro Leu Asp Gly Asp Val Gln Pro Ala Thr Trp
                 170                 175                 180

 cgt cta tct gcc ctg ccg ccc cgc ctc cgc agc gtg gac acc ttc agg      629
 Arg Leu Ser Ala Leu Pro Pro Arg Leu Arg Ser Val Asp Thr Phe Arg
             185                 190                 195

 ggg att gct ctt ata ctc atg gtc ttt gtc aat tat gga gga gga aaa      677
 Gly Ile Ala Leu Ile Leu Met Val Phe Val Asn Tyr Gly Gly Gly Lys
         200                 205                 210

 tat tgg tac ttc aaa cat gca agt tgg aat ggg ctg aca gtg gct gac      725
 Tyr Trp Tyr Phe Lys His Ala Ser Trp Asn Gly Leu Thr Val Ala Asp
     215                 220                 225

 ctc gtg ttc ccg tgg ttt gta ttt att atg gga tct tcc att ttt cta      773
 Leu Val Phe Pro Trp Phe Val Phe Ile Met Gly Ser Ser Ile Phe Leu
 230                 235                 240                 245

 tcg atg act tct ata ctg caa cgg ggg tgt tca aaa ttc aga ttg ctg      821
 Ser Met Thr Ser Ile Leu Gln Arg Gly Cys Ser Lys Phe Arg Leu Leu
                 250                 255                 260

 ggg aag att gca tgg agg agt ttc ctg tta atc tgc ata gga att atc      869
 Gly Lys Ile Ala Trp Arg Ser Phe Leu Leu Ile Cys Ile Gly Ile Ile
             265                 270                 275

 att gtg aat ccc aat tat tgc ctt ggt cca ttg tct tgg gac aag gtg      917
 Ile Val Asn Pro Asn Tyr Cys Leu Gly Pro Leu Ser Trp Asp Lys Val
         280                 285                 290

 cgc att cct ggt gtg ctg cag cga ttg gga gtg aca tac ttt gtg gtt      965
 Arg Ile Pro Gly Val Leu Gln Arg Leu Gly Val Thr Tyr Phe Val Val
     295                 300                 305

 gct gtg ttg gag ctc ctc ttt gct aaa cct gtg cct gaa cat tgt gcc     1013
 Ala Val Leu Glu Leu Leu Phe Ala Lys Pro Val Pro Glu His Cys Ala
 310                 315                 320                 325

 tcg gag agg agc tgc ctt tct ctt cga gac atc acg tcc agc tgg ccc     1061
 Ser Glu Arg Ser Cys Leu Ser Leu Arg Asp Ile Thr Ser Ser Trp Pro
                 330                 335                 340

 cag tgg ctg ctc atc ctg gtg ctg gaa ggc ctg tgg ctg ggc ttg aca     1109
 Gln Trp Leu Leu Ile Leu Val Leu Glu Gly Leu Trp Leu Gly Leu Thr
             345                 350                 355

 ttc ctc ctg cca gtc cct ggg tgc cct act ggt tat ctt ggt cct ggg     1157
 Phe Leu Leu Pro Val Pro Gly Cys Pro Thr Gly Tyr Leu Gly Pro Gly
         360                 365                 370

 ggc att gga gat ttt ggc aag tat cca aat tgc act gga gga gct gca     1205
 Gly Ile Gly Asp Phe Gly Lys Tyr Pro Asn Cys Thr Gly Gly Ala Ala
     375                 380                 385

 ggc tac atc gac cgc ctg ctg ctg gga gac gat cac ctt tac cag cac     1253
 Gly Tyr Ile Asp Arg Leu Leu Leu Gly Asp Asp His Leu Tyr Gln His
 390                 395                 400                 405

 cca tct tct gct gta ctt tac cac acc gag gtg gcc tat gac ccc gag     1301
 Pro Ser Ser Ala Val Leu Tyr His Thr Glu Val Ala Tyr Asp Pro Glu
                 410                 415                 420

 ggc atc ctg ggc acc atc aac tcc atc gtg atg gcc ttt tta gga gtt     1349
 Gly Ile Leu Gly Thr Ile Asn Ser Ile Val Met Ala Phe Leu Gly Val
             425                 430                 435

 cag gca gga aaa ata cta ttg tat tac aag gct cgg acc aaa gac atc     1397
 Gln Ala Gly Lys Ile Leu Leu Tyr Tyr Lys Ala Arg Thr Lys Asp Ile
         440                 445                 450

 ctg att cga ttc act gct tgg tgt tgt att ctt ggg ctc att tct gtt     1445
 Leu Ile Arg Phe Thr Ala Trp Cys Cys Ile Leu Gly Leu Ile Ser Val
     455                 460                 465

 gct ctg acg aag gtt tct gaa aat gaa ggc ttt att cca gta aac aaa     1493
 Ala Leu Thr Lys Val Ser Glu Asn Glu Gly Phe Ile Pro Val Asn Lys
 470                 475                 480                 485

 aat ctc tgg tcc ctt tcg tat gtc act acg ctc agt tct ttt gcc ttc     1541
 Asn Leu Trp Ser Leu Ser Tyr Val Thr Thr Leu Ser Ser Phe Ala Phe
                 490                 495                 500

 ttc atc ctg ctg gtc ctg tac cca gtt gtg gat gtg aag ggg ctg tgg     1589
 Phe Ile Leu Leu Val Leu Tyr Pro Val Val Asp Val Lys Gly Leu Trp
             505                 510                 515

 aca gga acc cca ttc ttt tat cca gga atg aat tcc att ctg gta tac     1637
 Thr Gly Thr Pro Phe Phe Tyr Pro Gly Met Asn Ser Ile Leu Val Tyr
         520                 525                 530

 gtc ggc cac gag gtg ttt gag aac tac ttc ccc ttt cag tgg aag ctg     1685
 Val Gly His Glu Val Phe Glu Asn Tyr Phe Pro Phe Gln Trp Lys Leu
     535                 540                 545

 aag gac aac cag tcc cac aag gag cac ctg act cag aac atc gtc gcc     1733
 Lys Asp Asn Gln Ser His Lys Glu His Leu Thr Gln Asn Ile Val Ala
 550                 555                 560                 565

 act gcc ctc tgg gtg ctc att gcc tac atc ctc tat aga aag aag att     1781
 Thr Ala Leu Trp Val Leu Ile Ala Tyr Ile Leu Tyr Arg Lys Lys Ile
                 570                 575                 580

 ttt tgg aaa atc tga tggctcccac tgagatgtgc tgctggaaga ctctagtagg     1836
 Phe Trp Lys Ile 
             585

 cctgcaggga ggactgaagc agcctttgtt aaagggaagc attcattagg aaattgactg   1896

 gctgcgtgtt tacagactct gggggaagac actgatgtcc tcaaactggt taactgtgac   1956

 acggctcgcc agaactctgc ctgtctattt gtgacttaca gatttgaaat gtaattgtct   2016

 tttttcctcc atcttctgtg gaaatggatg tctttggaac ttcattccga ggagataagc   2076

 tttaactttc caaaagggaa ttggcatggg tgggtttctt ctgggcggat ggaaacaatg   2136

 tgagggactg gtacttgctg gccttgttgc cctgccgagt gggtttccgc              2186




      <210> 253
      <211> 1848
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(1794)

      <400> 253
 tttcagacat acacaaaagt agagaaaata gtaaatgagc cccatatcac gagattcaac     60

 atttgtcgag attttgcc  atg ctt gat tca ttt atc aac gct ctc att ttt     111
                      Met Leu Asp Ser Phe Ile Asn Ala Leu Ile Phe
                        1               5                  10

 ttg ggt tac ctt ggc ttt cat tgg gat cag ttt gct ggt tat agg aac      159
 Leu Gly Tyr Leu Gly Phe His Trp Asp Gln Phe Ala Gly Tyr Arg Asn
              15                  20                  25

 tac act ggt tgg gca gct gcc aga cag cag tca gta gat aat gaa att      207
 Tyr Thr Gly Trp Ala Ala Ala Arg Gln Gln Ser Val Asp Asn Glu Ile
          30                  35                  40

 tca atg aag ggg tgg aag aca att gtc gta ggg ttg ata aag agt gga      255
 Ser Met Lys Gly Trp Lys Thr Ile Val Val Gly Leu Ile Lys Ser Gly
      45                  50                  55

 cag tcg tgc agg agt atg att aca caa agg gag tat gat gta atg gta      303
 Gln Ser Cys Arg Ser Met Ile Thr Gln Arg Glu Tyr Asp Val Met Val
  60                  65                  70                  75

 aca aac tgg ggg aac tta gaa tgg gct gtt tgt tca ggt tct tct ctg      351
 Thr Asn Trp Gly Asn Leu Glu Trp Ala Val Cys Ser Gly Ser Ser Leu
                  80                  85                  90

 tgt cct ggt gtc ttc aga gag gtg agt gcc ggg ctc ggc gct ctg ctc      399
 Cys Pro Gly Val Phe Arg Glu Val Ser Ala Gly Leu Gly Ala Leu Leu
              95                 100                 105

 ctg gag ctc ccg cgg gac tgc ctg ggg aca ggg act gct gtg gcg ctc      447
 Leu Glu Leu Pro Arg Asp Cys Leu Gly Thr Gly Thr Ala Val Ala Leu
         110                 115                 120

 ggc cct cca ctg cgg acc tct cct gag tgg gtg cgc cga gtc atg gag      495
 Gly Pro Pro Leu Arg Thr Ser Pro Glu Trp Val Arg Arg Val Met Glu
     125                 130                 135

 ggc gca gag ctg gcc ggg aag atc ctt tcc acc tgg ctg acg ctg gtt      543
 Gly Ala Glu Leu Ala Gly Lys Ile Leu Ser Thr Trp Leu Thr Leu Val
 140                 145                 150                 155

 ctc ggc ttc atc ctt tta cct tcg gtc ttc gga gtg tct ctg ggc atc      591
 Leu Gly Phe Ile Leu Leu Pro Ser Val Phe Gly Val Ser Leu Gly Ile
                 160                 165                 170

 tcc gag atc tac atg aag atc cta gtg aaa act tta gag tgg gcc aca      639
 Ser Glu Ile Tyr Met Lys Ile Leu Val Lys Thr Leu Glu Trp Ala Thr
             175                 180                 185

 ata cga att gaa aaa gga acc cca aag gag tcg att ctt aaa aac tct      687
 Ile Arg Ile Glu Lys Gly Thr Pro Lys Glu Ser Ile Leu Lys Asn Ser
         190                 195                 200

 gct tct gtt ggt att atc caa aga gat gag tca ccc atg gaa aaa ggg      735
 Ala Ser Val Gly Ile Ile Gln Arg Asp Glu Ser Pro Met Glu Lys Gly
     205                 210                 215

 ctc tct ggt cta cga gga agg gac ttt gag ctg tct gac gtg ttt tat      783
 Leu Ser Gly Leu Arg Gly Arg Asp Phe Glu Leu Ser Asp Val Phe Tyr
 220                 225                 230                 235

 ttc tcc aag aag gga ttg gaa gcc att gta gaa gat gaa gtg acc cag      831
 Phe Ser Lys Lys Gly Leu Glu Ala Ile Val Glu Asp Glu Val Thr Gln
                 240                 245                 250

 agg ttt tcc tca gag gag cta gtg tca tgg aat ctc ctc aca aga acc      879
 Arg Phe Ser Ser Glu Glu Leu Val Ser Trp Asn Leu Leu Thr Arg Thr
             255                 260                 265

 aat gta aat ttc cag tac atc agt ctg cgg ctc act atg gtg tgg gtg      927
 Asn Val Asn Phe Gln Tyr Ile Ser Leu Arg Leu Thr Met Val Trp Val
         270                 275                 280

 ctg ggc gtc ata gtg cgc tat tgt gtc cta ctg cct ctg agg gtt acc      975
 Leu Gly Val Ile Val Arg Tyr Cys Val Leu Leu Pro Leu Arg Val Thr
     285                 290                 295

 ttg gct ttc att ggg atc agt ttg ctg gtt ata gga act aca ctg gtt     1023
 Leu Ala Phe Ile Gly Ile Ser Leu Leu Val Ile Gly Thr Thr Leu Val
 300                 305                 310                 315

 ggg cag ctg cca gac agc agc ctc aaa aac tgg ctg agt gaa ctg gtc     1071
 Gly Gln Leu Pro Asp Ser Ser Leu Lys Asn Trp Leu Ser Glu Leu Val
                 320                 325                 330

 cat ctg act tgc tgc cgg atc tgt gtg cga gcc ctc tct ggt acc att     1119
 His Leu Thr Cys Cys Arg Ile Cys Val Arg Ala Leu Ser Gly Thr Ile
             335                 340                 345

 cat tat cat aac aag cag tac aga ccc cag aag gga ggc att tgt gtt     1167
 His Tyr His Asn Lys Gln Tyr Arg Pro Gln Lys Gly Gly Ile Cys Val
         350                 355                 360

 gcc aac cat act tcc ccc att gat gtt tta atc ttg aca acg gat gga     1215
 Ala Asn His Thr Ser Pro Ile Asp Val Leu Ile Leu Thr Thr Asp Gly
     365                 370                 375

 tgt tat gct atg gtt ggc cag gtt cat ggc ggc ttg atg gga att att     1263
 Cys Tyr Ala Met Val Gly Gln Val His Gly Gly Leu Met Gly Ile Ile
 380                 385                 390                 395

 cag aga gct atg gtc aag gct tgt cct cat gtc tgg ttt gaa cgc tca     1311
 Gln Arg Ala Met Val Lys Ala Cys Pro His Val Trp Phe Glu Arg Ser
                 400                 405                 410

 gaa atg aag gat cga cac ctg gtt act aag aga cta aaa gaa cat att     1359
 Glu Met Lys Asp Arg His Leu Val Thr Lys Arg Leu Lys Glu His Ile
             415                 420                 425

 gct gat aag aag aaa cta ccc ata cta att ttt cct gaa gga act tgc     1407
 Ala Asp Lys Lys Lys Leu Pro Ile Leu Ile Phe Pro Glu Gly Thr Cys
         430                 435                 440

 atc aac aat act tca gtc atg atg ttt aaa aag ggg agc ttt gaa att     1455
 Ile Asn Asn Thr Ser Val Met Met Phe Lys Lys Gly Ser Phe Glu Ile
     445                 450                 455

 gga gga acc ata cat cca gtt gca att aag tat aac cct cag ttc ggt     1503
 Gly Gly Thr Ile His Pro Val Ala Ile Lys Tyr Asn Pro Gln Phe Gly
 460                 465                 470                 475

 gat gca ttt tgg aac agt agt aaa tac aac atg gtg agc tac ctg ctt     1551
 Asp Ala Phe Trp Asn Ser Ser Lys Tyr Asn Met Val Ser Tyr Leu Leu
                 480                 485                 490

 cga atg atg acc agc tgg gcc atc gtc tgt gac gtg tgg tac atg ccc     1599
 Arg Met Met Thr Ser Trp Ala Ile Val Cys Asp Val Trp Tyr Met Pro
             495                 500                 505

 ccc atg acc aga gag gaa gga gaa gat gca gtc cag ttt gct aac agg     1647
 Pro Met Thr Arg Glu Glu Gly Glu Asp Ala Val Gln Phe Ala Asn Arg
         510                 515                 520

 gtt aag tct gct att gct ata caa gga ggc ctg act gaa ctt ccc tgg     1695
 Val Lys Ser Ala Ile Ala Ile Gln Gly Gly Leu Thr Glu Leu Pro Trp
     525                 530                 535

 gat gga gga cta aag aga gca aag gtg aag gac atc ttt aag gaa gag     1743
 Asp Gly Gly Leu Lys Arg Ala Lys Val Lys Asp Ile Phe Lys Glu Glu
 540                 545                 550                 555

 cag cag aaa aat tac agc aag atg att gtg ggc aat gga tct ctc agc     1791
 Gln Gln Lys Asn Tyr Ser Lys Met Ile Val Gly Asn Gly Ser Leu Ser
                 560                 565                 570

 taa gagg acggatgaca gcctttagat ctagaactag cccttagaaa tggaatggct     1848
 






      <210> 254
      <211> 2638
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (264)..(1025)

      <400> 254
 cggacgcgtg ggctggagtc ttctcggtca cgttttctgt tatatttgcc tatgtagctg     60

 atgtcactca ggagcacgag cgaagtacag cttatggatg ggtctcagcc acctttgcgg    120

 ctagtcttgt cagcagcccg gccattggag catatctttc tgccagttac ggagacagcc    180

 tcgttgtgct ggtggccaca gtggtggctc ttctggacat ctgcttcatc ttagtggctg    240

 ttccagaatc tctgcctgag aaa    atg aga ccg gtt tcc tgg gga gct cag     290
                              Met Arg Pro Val Ser Trp Gly Ala Gln
                                1               5

 att tct tgg aaa caa gca gac cct ttt gcg tcg ttg aag aaa gtt gga      338
 Ile Ser Trp Lys Gln Ala Asp Pro Phe Ala Ser Leu Lys Lys Val Gly
  10                  15                  20                  25

 aaa gat tct act gtc tta cta atc tgc atc acc gtg tgt ctt tca tac      386
 Lys Asp Ser Thr Val Leu Leu Ile Cys Ile Thr Val Cys Leu Ser Tyr
                  30                  35                  40

 ctt cct gaa gct gga cag tat tca agt ttt ttt ctc tat ctc agg cag      434
 Leu Pro Glu Ala Gly Gln Tyr Ser Ser Phe Phe Leu Tyr Leu Arg Gln
              45                  50                  55

 gtc ata ggt ttt gga tct gtt aaa att gca gca ttc ata gct atg gta      482
 Val Ile Gly Phe Gly Ser Val Lys Ile Ala Ala Phe Ile Ala Met Val
          60                  65                  70

 gga att ctg tct att gtg gct cag acg gcc ttt ctt agc atc ttg atg      530
 Gly Ile Leu Ser Ile Val Ala Gln Thr Ala Phe Leu Ser Ile Leu Met
      75                  80                  85

 aga tca tta gga aat aag aat act gtc ctc ctt ggc ttg ggc ttc cag      578
 Arg Ser Leu Gly Asn Lys Asn Thr Val Leu Leu Gly Leu Gly Phe Gln
  90                  95                 100                 105

 atg ctc cag tta gcc tgg tac ggt ttt gga tca cag gcc tgg atg atg      626
 Met Leu Gln Leu Ala Trp Tyr Gly Phe Gly Ser Gln Ala Trp Met Met
                 110                 115                 120

 tgg gca gca ggg acc gtg gct gcc atg tcc agc atc acg ttt ccg gca      674
 Trp Ala Ala Gly Thr Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala
             125                 130                 135

 atc agt gcc ctc gtc tct cgg aat gca gag tca gat cag caa gga gtt      722
 Ile Ser Ala Leu Val Ser Arg Asn Ala Glu Ser Asp Gln Gln Gly Val
         140                 145                 150

 gcc cag ggg atc ata act gga ata aga gga cta tgc aat ggc ctg ggg      770
 Ala Gln Gly Ile Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly
     155                 160                 165

 cca gca ctg tat ggc ttc ata ttc tac atg ttc cat gtg gaa ctg act      818
 Pro Ala Leu Tyr Gly Phe Ile Phe Tyr Met Phe His Val Glu Leu Thr
 170                 175                 180                 185

 gag ttg ggc ccg aaa ttg aat tct aac aac gtt ccc ctg cag gga gct      866
 Glu Leu Gly Pro Lys Leu Asn Ser Asn Asn Val Pro Leu Gln Gly Ala
                 190                 195                 200

 gtc atc cca ggc ccg ccg ttt tta ttt ggg gca tgt ata gtc ctt atg      914
 Val Ile Pro Gly Pro Pro Phe Leu Phe Gly Ala Cys Ile Val Leu Met
             205                 210                 215

 tct ttt ctg gtt gcc tta ttc att cct gaa tac agt aaa gcc agt gga      962
 Ser Phe Leu Val Ala Leu Phe Ile Pro Glu Tyr Ser Lys Ala Ser Gly
         220                 225                 230

 gtt caa aaa cac agt aac agc agc agc ggc agc ctg acc aac acc cca     1010
 Val Gln Lys His Ser Asn Ser Ser Ser Gly Ser Leu Thr Asn Thr Pro
     235                 240                 245

 gaa cgg ggc agc tga tgagcgacat tgagccacta ctgcaaagac agcagcatct     1065
 Glu Arg Gly Ser 
 250

 gggagctctc ttcatttgaa ggagcctggg aatcagtgca ctgagctgta aactcgggac   1125

 gaaagtggga ttctgcttac gccatctctg agagccatgg agggagccac acccctggtg   1185

 acttcatggt gctggatggg agacgctagc ggcatccttc agggccaagt ttgataaata   1245

 ccaccgccat cattctgctc atcctcctcc tgtttttttt tttctcttac attctttttt   1305

 ttttttcctg tttatacatt agaacaagat aagatttgaa atacttcctt gcaaataatg   1365

 tgcaactccc aaggtgaaac tcaaatagaa aaagtcatct ctctggtaga aaggatggct   1425

 ttcctgtaat gactatagag taagagtggc agcaatcttt ccatgcccct tttcagcaga   1485

 aggcacagaa cagtagcggg actgccatct ctggcaagat ttcaggtaaa gaatctcttc   1545

 ttaatttcta ccttcctgtt tctctgaatc agcccatagg tgttgatgag tggccactct   1605

 taaagagtca ctcagtatca gggatctact gtctttgttc aaaggtcaaa taaaaaccta   1665

 gtctcctttt attctacttt ctattcttag ctagaatgaa actcagcata tatacacttc   1725

 tggacataat aatattgaat agtaattacc tttactagat gaaagaaatt ttcattacaa   1785

 acttaaatca tgtaaaactc aacaactcag attcctggac ctggtgtcct ggttgggtcc   1845

 aaggtgattt tacagaagaa aaaaacaact caagcattct ggtggcaaca tagagattgt   1905

 aggctgcttc taagaaagtt attaacaatt tggaaattcc taagtaggat gagagttagt   1965

 aactggatac gagtgaagtt tatatccaag ttcagactca aaggcattat tatgatttgc   2025

 ttcttcccat gtcttccatg tcctgcttct caaagttttt ctcatcccat cacactcctg   2085

 ccttaactgc tctgagtatg catttgtttt caattcatct ttatttcaat ctgtttaact   2145

 tttgaatcgc atgggaatac gcacattaag ttcctttcta aaataaggtt ttatgaagct   2205

 gagtttcacg ataagtgtct tgctattttt tgagatgttt tatggacaaa gaaaacttta   2265

 cagatttata tgtattttgc tgcaccagta aatggaccat taactagggc ccacctttaa   2325

 cagagcaccc ctttgaaagt tttataggta tgaaatatat gtagatattt gtaaagggtt   2385

 ttaatttttt tttttgatgg ggtgctgtgt aaatcttgta tttataaatg taatgaaggt   2445

 attgacagaa aaaaatatat acaactttta taaaggattg tgtactgact gaatacattt   2505

 aaaagaaaat atattttgaa acctgttctg ctatgaacag agataacata tctttttact   2565

 atgctattgg tttttaggtt aagcttccta atgcataata aatttacagt ggttactttt   2625

 aaaaaaaaaa aaa                                                      2638




      <210> 255
      <211> 859
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(788)

      <400> 255
 tttct    atg gct tta tct gag agt gga aga ggt aaa gaa cta ata cca      47
          Met Ala Leu Ser Glu Ser Gly Arg Gly Lys Glu Leu Ile Pro
            1               5                  10

 tgg gca ata aat atg act ttc aca gtg atg gat cag cca atg ggt atc       95
 Trp Ala Ile Asn Met Thr Phe Thr Val Met Asp Gln Pro Met Gly Ile
  15                  20                  25                  30

 tac tgt cca gtc tcc agg gaa tac gtg aag tct gtc tac cct gag gat      143
 Tyr Cys Pro Val Ser Arg Glu Tyr Val Lys Ser Val Tyr Pro Glu Asp
                  35                  40                  45

 gcc aca ccc agc cct gtg tat gaa agg gat ttc acg gct gtg cac atc      191
 Ala Thr Pro Ser Pro Val Tyr Glu Arg Asp Phe Thr Ala Val His Ile
              50                  55                  60

 tgg ggc cca aac aca aag cgg agc cca ggc gac cac cgg ctg gtg ctg      239
 Trp Gly Pro Asn Thr Lys Arg Ser Pro Gly Asp His Arg Leu Val Leu
          65                  70                  75

 gcc gcg gtg gag aca acc gtg ctg gtg ctc atc ttt gca gtg tcg ctg      287
 Ala Ala Val Glu Thr Thr Val Leu Val Leu Ile Phe Ala Val Ser Leu
      80                  85                  90

 ctg ggc aac gtg tgc gcc ctg gtg ctg gtg gcg cgc cga cga cgc cgc      335
 Leu Gly Asn Val Cys Ala Leu Val Leu Val Ala Arg Arg Arg Arg Arg
  95                 100                 105                 110

 ggc gcg act gcc tgc ctg gta ctc aac ctc ttc tgc gcg gac ctg ctc      383
 Gly Ala Thr Ala Cys Leu Val Leu Asn Leu Phe Cys Ala Asp Leu Leu
                 115                 120                 125

 ttc atc agc gct atc cct ctg gtg ctg gcc gtg cgc tgg act gag gcc      431
 Phe Ile Ser Ala Ile Pro Leu Val Leu Ala Val Arg Trp Thr Glu Ala
             130                 135                 140

 tgg ctg ctg ggc ccc gtt gcc tgc cac ctg ctc ttc tac gtg atg acc      479
 Trp Leu Leu Gly Pro Val Ala Cys His Leu Leu Phe Tyr Val Met Thr
         145                 150                 155

 ctg agc ggc agc gtc acc atc ctc acg ctg gcc gcg gtc agc ctg gag      527
 Leu Ser Gly Ser Val Thr Ile Leu Thr Leu Ala Ala Val Ser Leu Glu
     160                 165                 170

 cgc atg gtg tgc atc gtg cac ctg cag cgc ggc gtg cgg ggt cct ggg      575
 Arg Met Val Cys Ile Val His Leu Gln Arg Gly Val Arg Gly Pro Gly
 175                 180                 185                 190

 cgg cgg gcg cgg gca gtg ctg ctg gcg ctc atc tgg ggc tat tcg gcg      623
 Arg Arg Ala Arg Ala Val Leu Leu Ala Leu Ile Trp Gly Tyr Ser Ala
                 195                 200                 205

 gtc gcc gct ctg cct ctc tgc gtc ttc ttc cga gtc gtc ccg caa cgg      671
 Val Ala Ala Leu Pro Leu Cys Val Phe Phe Arg Val Val Pro Gln Arg
             210                 215                 220

 ctc ccc ggc gcc gac cag gtg agc gcc cct ctg tgt gtg ccg ggc agg      719
 Leu Pro Gly Ala Asp Gln Val Ser Ala Pro Leu Cys Val Pro Gly Arg
         225                 230                 235

 tgt cct gcg cag gct ggg aag cgg ggc ccc gac gga agc tgg gat gag      767
 Cys Pro Ala Gln Ala Gly Lys Arg Gly Pro Asp Gly Ser Trp Asp Glu
     240                 245                 250

 gat gat caa gaa caa caa tag cc atttattgca cttaatcgtt gtgccaaatc      820
 Asp Asp Gln Glu Gln Gln 
 255                 260

 ttgtgcccat ggacactgga tgtgcgaagc cttttgtga                           859




      <210> 256
      <211> 2351
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1371)

      <400> 256
  atg ccg atg cag ctg ctg ctt aca gat ttt att atc ttt tcc atc aga      48
  Met Pro Met Gln Leu Leu Leu Thr Asp Phe Ile Ile Phe Ser Ile Arg
    1               5                  10                  15

 ttc atc atc aac agc atg gaa gcg aga aac caa aca gct att tca aaa       96
 Phe Ile Ile Asn Ser Met Glu Ala Arg Asn Gln Thr Ala Ile Ser Lys
              20                  25                  30

 ttc ctt ctc ctg gga ctg ata gag gat ccg gaa ctg cag ccc gtc ctt      144
 Phe Leu Leu Leu Gly Leu Ile Glu Asp Pro Glu Leu Gln Pro Val Leu
          35                  40                  45

 ttc agc ctg ttc ctg tcc atg tac ttg gtc acc atc ctg ggg aac ctg      192
 Phe Ser Leu Phe Leu Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu
      50                  55                  60

 ctc atc ctc ttg gct gtc atc tct gac tct cac ctc cac acc ccc atg      240
 Leu Ile Leu Leu Ala Val Ile Ser Asp Ser His Leu His Thr Pro Met
  65                  70                  75                  80

 tac ttc ttc ctc tcc aat ctc tcc ttt ttg gac att tgt tta agc aca      288
 Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Leu Ser Thr
                  85                  90                  95

 acc acg atc cca aag atg ctg gtg aac atc caa gct cag aat cgg agc      336
 Thr Thr Ile Pro Lys Met Leu Val Asn Ile Gln Ala Gln Asn Arg Ser
             100                 105                 110

 atc acg tac tca ggc tgc ctc acc cag atc tgc ttt gtc ttg ttt ttt      384
 Ile Thr Tyr Ser Gly Cys Leu Thr Gln Ile Cys Phe Val Leu Phe Phe
         115                 120                 125

 gct ggc ttg gaa aat tgt ctc ctt gca gca atg gcc tat gac cgc tat      432
 Ala Gly Leu Glu Asn Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr
     130                 135                 140

 gtg gcc att tgt cac ccc ctt aga tac aca gtc atc atg aac ccc cgc      480
 Val Ala Ile Cys His Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Arg
 145                 150                 155                 160

 ctc tgt ggc ctg ctg att ctt ctc tct ctg ttg act agt gtt gtg aat      528
 Leu Cys Gly Leu Leu Ile Leu Leu Ser Leu Leu Thr Ser Val Val Asn
                 165                 170                 175

 gcc ctt ctt ctc agc ctg atg gtg ttg agg ctg tcc ttc tgc aca gac      576
 Ala Leu Leu Leu Ser Leu Met Val Leu Arg Leu Ser Phe Cys Thr Asp
             180                 185                 190

 ctg gaa atc ccg ctc ttc ttc tgt gaa ctg gct cag gtc atc caa ctc      624
 Leu Glu Ile Pro Leu Phe Phe Cys Glu Leu Ala Gln Val Ile Gln Leu
         195                 200                 205

 acc tgt tca gac acc ctc atc aat aac atc ctg ata tat ttt gca gct      672
 Thr Cys Ser Asp Thr Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ala
     210                 215                 220

 tgc ata ttt ggt ggt gtt cct ctg tct gga atc att ttg tct tac act      720
 Cys Ile Phe Gly Gly Val Pro Leu Ser Gly Ile Ile Leu Ser Tyr Thr
 225                 230                 235                 240

 cag atc acc tcc tgt gtt ttg aga atg cca tca gca agt gga aag cac      768
 Gln Ile Thr Ser Cys Val Leu Arg Met Pro Ser Ala Ser Gly Lys His
                 245                 250                 255

 aaa gca gtt tcc acc tgt ggg tct cac ctc tcc att gtt ctc ttg ttc      816
 Lys Ala Val Ser Thr Cys Gly Ser His Leu Ser Ile Val Leu Leu Phe
             260                 265                 270

 tat ggg gca ggt ttg ggg gtg tac att agt tct gtg gtt act gac tca      864
 Tyr Gly Ala Gly Leu Gly Val Tyr Ile Ser Ser Val Val Thr Asp Ser
         275                 280                 285

 cct agg aag act gca gtg gct tca gtg atg tat tct gtg ttc cct caa      912
 Pro Arg Lys Thr Ala Val Ala Ser Val Met Tyr Ser Val Phe Pro Gln
     290                 295                 300

 atg gtg aac ccc ttt atc tat agt ctg agg aat aag gac atg aaa gga      960
 Met Val Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly
 305                 310                 315                 320

 acc ttg agg aag ttc ata ggg agg ata cct tct ctt ctg tgg tgt gcc     1008
 Thr Leu Arg Lys Phe Ile Gly Arg Ile Pro Ser Leu Leu Trp Cys Ala
                 325                 330                 335

 att tgc ttt gga ttc agg ttt cta gat ggt gag gac cga gga ggg aca     1056
 Ile Cys Phe Gly Phe Arg Phe Leu Asp Gly Glu Asp Arg Gly Gly Thr
             340                 345                 350

 cag ata gac gcc aat ggt ggt ccc ata gaa gag agc aac cac aga cag     1104
 Gln Ile Asp Ala Asn Gly Gly Pro Ile Glu Glu Ser Asn His Arg Gln
         355                 360                 365

 gtg gga gct gca ggt gga gaa ggc ttt ctt cct gcc gcc tgc aga ggg     1152
 Val Gly Ala Ala Gly Gly Glu Gly Phe Leu Pro Ala Ala Cys Arg Gly
     370                 375                 380

 gac ctt cat gat ggc cac aag gat gcg agc ata gga ggc cag gat gca     1200
 Asp Leu His Asp Gly His Lys Asp Ala Ser Ile Gly Gly Gln Asp Ala
 385                 390                 395                 400

 gac aaa ggg cgt ggc tat cac cat ccc tgc cac aat gag gat gaa gat     1248
 Asp Lys Gly Arg Gly Tyr His His Pro Cys His Asn Glu Asp Glu Asp
                 405                 410                 415

 cct att cac aga ggt gtc cgt gca cga aag tcg gag gat ggg agt gag     1296
 Pro Ile His Arg Gly Val Arg Ala Arg Lys Ser Glu Asp Gly Ser Glu
             420                 425                 430

 gtc gca gaa gta gtg agg cac ctc atg gct gcc gca gaa aac gag acg     1344
 Val Ala Glu Val Val Arg His Leu Met Ala Ala Ala Glu Asn Glu Thr
         435                 440                 445

 ggc cat cag gag gat gtg agt gag tga gatga agcaggaaaa cgcccagagg     1396
 Gly His Gln Glu Asp Val Ser Glu 
     450                 455

 gcgccgacca gcaggcgaca gaggcgtagg ctcatgatct tggcgtagtg caatgggtgg   1456

 cagatggcca cgaaccggtc ataagccatc atggcgatta tgacgctgtc cacgatgcca   1516

 aagaaatgga agaagtacat ctggatcagg cagcagggat aagagatggc cttgctcccg   1576

 gtttgaaggc tcaccagcat cttagggatg gtgttggtgg ccagacagaa atcaaccagg   1636

 gacaggttgg ccaggaagaa gtacatgggg gtgtggaggt gggagtctat gctgatggcc   1696

 aggatgatga gcaggttccc cacgaccatg accaggtaca tgcagaagaa cagggaaaag   1756

 agaagcgtct cctgctctgg cttttctgag agtcccagga ggatgaattg agatgcactg   1816

 gtttggtttc ttggttccat gggtgtgatt cctctggtac agtcctgggg aacctgctca   1876

 tcatcctggc catcagcata gactcccacc tccacacccc catgtacttc ttcctggcca   1936

 acctgtccct gattgatttc tgtctggcca ccaacaccat ccccaagatg ctggcccagt   1996

 cccaaggcgc aaggccactt acagtaatca gcagcgtggg tcagcaagac agcggaagca   2056

 ggacgacagc cggccggaag acatgtaccc tggccggaag acacgtaccc tggccggaag   2116

 acatctaccc tggccggaag acatctaccc tggccggaag acacctaccc tggccggaag   2176

 acatctaccc tggccggaag acatctaccc tggccggaag acagctacct tggccggaag   2236

 acacctgccc tggccggaag acacgtaccc tggctggaag acatctaccc tggccggaag   2296

 acacatgccc ctgaagatca agagacgggc catccgggta ccatgtagca gttac        2351




      <210> 257
      <211> 2347
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2229)

      <400> 257
  atg gag gaa aaa gaa gag att gtg gga gag aga atg aaa tat cag gat      48
  Met Glu Glu Lys Glu Glu Ile Val Gly Glu Arg Met Lys Tyr Gln Asp
    1               5                  10                  15

 aaa gca gct gca tcc aca tct gct gct aag caa aga aat cca gaa aca       96
 Lys Ala Ala Ala Ser Thr Ser Ala Ala Lys Gln Arg Asn Pro Glu Thr
              20                  25                  30

 gag acc cat ggt ccc cag aat aca gcc gcg agt act ttg aac act gat      144
 Glu Thr His Gly Pro Gln Asn Thr Ala Ala Ser Thr Leu Asn Thr Asp
          35                  40                  45

 gca tcc tcg gtc aca gtt ctc act gct agt ttc aca gag acc agc aca      192
 Ala Ser Ser Val Thr Val Leu Thr Ala Ser Phe Thr Glu Thr Ser Thr
      50                  55                  60

 gtt tca ctg gat aat gaa act aca gta aaa acc tca gat atc ctt gac      240
 Val Ser Leu Asp Asn Glu Thr Thr Val Lys Thr Ser Asp Ile Leu Asp
  65                  70                  75                  80

 gca cgg aaa aca aat gag ctc ccc tca gat agc agt tct tct tct gat      288
 Ala Arg Lys Thr Asn Glu Leu Pro Ser Asp Ser Ser Ser Ser Ser Asp
                  85                  90                  95

 ctg atc aac acc tcc ata gct tct tca act atg gat gtc act aaa aca      336
 Leu Ile Asn Thr Ser Ile Ala Ser Ser Thr Met Asp Val Thr Lys Thr
             100                 105                 110

 gcc tcc atc agt ccc act agc atc tca gga atg aca gca agt tcc tcc      384
 Ala Ser Ile Ser Pro Thr Ser Ile Ser Gly Met Thr Ala Ser Ser Ser
         115                 120                 125

 cca tct ctc ttc tct tca gat aga ccc cag gtt ccc aca tct aca aca      432
 Pro Ser Leu Phe Ser Ser Asp Arg Pro Gln Val Pro Thr Ser Thr Thr
     130                 135                 140

 gag aca aat aca gcc acc tct cca tct gtt tcc agt aac acc tat tct      480
 Glu Thr Asn Thr Ala Thr Ser Pro Ser Val Ser Ser Asn Thr Tyr Ser
 145                 150                 155                 160

 ctt gat ggg ggc tcc aat gtg ggt ggc act cca tcc act tta cca ccc      528
 Leu Asp Gly Gly Ser Asn Val Gly Gly Thr Pro Ser Thr Leu Pro Pro
                 165                 170                 175

 ttt aca atc acc cac cct gtc gag aca agc tcg gcc cta tta gcc tgg      576
 Phe Thr Ile Thr His Pro Val Glu Thr Ser Ser Ala Leu Leu Ala Trp
             180                 185                 190

 tct aga cca gta aga act ttc agc acc atg gtc agc act gac act gcc      624
 Ser Arg Pro Val Arg Thr Phe Ser Thr Met Val Ser Thr Asp Thr Ala
         195                 200                 205

 tcc gga gaa aat cct acc tct agc aat tct gtg gtg act tct gtt cca      672
 Ser Gly Glu Asn Pro Thr Ser Ser Asn Ser Val Val Thr Ser Val Pro
     210                 215                 220

 gca cca ggt aca tgg acc agt gta ggc agt act act gac tta cct gcc      720
 Ala Pro Gly Thr Trp Thr Ser Val Gly Ser Thr Thr Asp Leu Pro Ala
 225                 230                 235                 240

 atg ggc ttt ctc aag aca agt cct gca gga gag gca cac tca ctt cta      768
 Met Gly Phe Leu Lys Thr Ser Pro Ala Gly Glu Ala His Ser Leu Leu
                 245                 250                 255

 gca tca act att gaa cca gcc act gcc ttc act ccc cat ctc tca gca      816
 Ala Ser Thr Ile Glu Pro Ala Thr Ala Phe Thr Pro His Leu Ser Ala
             260                 265                 270

 gca gtg gtc act gga tcc agt gct aca tca gaa gcc agt ctt ctc act      864
 Ala Val Val Thr Gly Ser Ser Ala Thr Ser Glu Ala Ser Leu Leu Thr
         275                 280                 285

 acg agt gaa agc aaa gcc att cat tct tca cca cag acc cca act aca      912
 Thr Ser Glu Ser Lys Ala Ile His Ser Ser Pro Gln Thr Pro Thr Thr
     290                 295                 300

 ccc acc tct gga gca aac tgg gaa act tca gct act cct gag agc ctt      960
 Pro Thr Ser Gly Ala Asn Trp Glu Thr Ser Ala Thr Pro Glu Ser Leu
 305                 310                 315                 320

 ttg gta gtc act gag act tca gac aca aca ctt acc tca aag att ttg     1008
 Leu Val Val Thr Glu Thr Ser Asp Thr Thr Leu Thr Ser Lys Ile Leu
                 325                 330                 335

 gtc aca gat acc atc ttg ttt tca act gtg tcc acg cca cct tct aaa     1056
 Val Thr Asp Thr Ile Leu Phe Ser Thr Val Ser Thr Pro Pro Ser Lys
             340                 345                 350

 ttt cca agt acg ggg act ctg tct gga gct tcc ttc cct act tta ctc     1104
 Phe Pro Ser Thr Gly Thr Leu Ser Gly Ala Ser Phe Pro Thr Leu Leu
         355                 360                 365

 ccg gac act cca gcc atc cct ctc act gcc act gag cca aca agt tca     1152
 Pro Asp Thr Pro Ala Ile Pro Leu Thr Ala Thr Glu Pro Thr Ser Ser
     370                 375                 380

 tta gct aca tcc ttt gat tcc acc cca ctg gtg act ata gct tcg gat     1200
 Leu Ala Thr Ser Phe Asp Ser Thr Pro Leu Val Thr Ile Ala Ser Asp
 385                 390                 395                 400

 agt ctt ggc aca gtc cca gag act acc ctg acc atg tca gag acc tca     1248
 Ser Leu Gly Thr Val Pro Glu Thr Thr Leu Thr Met Ser Glu Thr Ser
                 405                 410                 415

 aat ggt gat gca ctg gtt ctt aag aca gta agt aac cca gat agg agc     1296
 Asn Gly Asp Ala Leu Val Leu Lys Thr Val Ser Asn Pro Asp Arg Ser
             420                 425                 430

 atc cct gga atc act atc caa gga gta aca gaa agt cca ctc cat cct     1344
 Ile Pro Gly Ile Thr Ile Gln Gly Val Thr Glu Ser Pro Leu His Pro
         435                 440                 445

 tct tcc act tcc ccc tct aag att gtt gct cca cgg aat aca acc tat     1392
 Ser Ser Thr Ser Pro Ser Lys Ile Val Ala Pro Arg Asn Thr Thr Tyr
     450                 455                 460

 gaa ggt tcg atc aca gtg gca ctt tct act ttg cct gcg gga act act     1440
 Glu Gly Ser Ile Thr Val Ala Leu Ser Thr Leu Pro Ala Gly Thr Thr
 465                 470                 475                 480

 ggt tcc ctt gta ttc agt cag agt tct gaa aac tca gag aca acg gct     1488
 Gly Ser Leu Val Phe Ser Gln Ser Ser Glu Asn Ser Glu Thr Thr Ala
                 485                 490                 495

 ttg gta gac tca tca gct ggg ctt gag agg gca tct gtg atg cca cta     1536
 Leu Val Asp Ser Ser Ala Gly Leu Glu Arg Ala Ser Val Met Pro Leu
             500                 505                 510

 acc aca gga agc cag ggt atg gct agc tct gga gga atc aga agt ggg     1584
 Thr Thr Gly Ser Gln Gly Met Ala Ser Ser Gly Gly Ile Arg Ser Gly
         515                 520                 525

 tcc act cac tca act gga acc aaa aca ttt tct tct ctc cct ctg acc     1632
 Ser Thr His Ser Thr Gly Thr Lys Thr Phe Ser Ser Leu Pro Leu Thr
     530                 535                 540

 atg aac cca gca act gat gga acg cta gtg acc acc ata aag atg tca     1680
 Met Asn Pro Ala Thr Asp Gly Thr Leu Val Thr Thr Ile Lys Met Ser
 545                 550                 555                 560

 agc cag gca gca caa gga aat tcc acg tgg cct gcc cca gca gag gag     1728
 Ser Gln Ala Ala Gln Gly Asn Ser Thr Trp Pro Ala Pro Ala Glu Glu
                 565                 570                 575

 acg ggg acc agt cca gca gtc ctg ggg aac ctg ctc atc atc ctg gcc     1776
 Thr Gly Thr Ser Pro Ala Val Leu Gly Asn Leu Leu Ile Ile Leu Ala
             580                 585                 590

 atc agc ata gac tcc cac ctc cac acc ccc atg tac ttc ttc ctg gcc     1824
 Ile Ser Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala
         595                 600                 605

 aac ctg tcc ctg att gat ttc tgt ctg gcc acc aac acc atc ccc aag     1872
 Asn Leu Ser Leu Ile Asp Phe Cys Leu Ala Thr Asn Thr Ile Pro Lys
     610                 615                 620

 atg ctg gcc cag tcc caa ggt gca agg cta ctt gcc cca gca gca tgc     1920
 Met Leu Ala Gln Ser Gln Gly Ala Arg Leu Leu Ala Pro Ala Ala Cys
 625                 630                 635                 640

 gcc agc aag ata gca gaa gca gga aga gag atg gcc gga aga cat gta     1968
 Ala Ser Lys Ile Ala Glu Ala Gly Arg Glu Met Ala Gly Arg His Val
                 645                 650                 655

 ccc tgg ccg gaa gac acg tac cct ggc cgg aag aca tct acc ctg gcc     2016
 Pro Trp Pro Glu Asp Thr Tyr Pro Gly Arg Lys Thr Ser Thr Leu Ala
             660                 665                 670

 gga aga cat cta ccc tgg ccg gaa gac acc tac cct ggc cgg aag aca     2064
 Gly Arg His Leu Pro Trp Pro Glu Asp Thr Tyr Pro Gly Arg Lys Thr
         675                 680                 685

 tct acc ctg gcc gga aga cat cga ccc tgg ccg gaa gac agc tac ctt     2112
 Ser Thr Leu Ala Gly Arg His Arg Pro Trp Pro Glu Asp Ser Tyr Leu
     690                 695                 700

 ggc cgg aag aca cct gcc ctg gcc gga aga cac gta ccc tgg ctg gaa     2160
 Gly Arg Lys Thr Pro Ala Leu Ala Gly Arg His Val Pro Trp Leu Glu
 705                 710                 715                 720

 gac atc tac cct ggc cgg aag aca cat gcc cct gaa gat caa gag acg     2208
 Asp Ile Tyr Pro Gly Arg Lys Thr His Ala Pro Glu Asp Gln Glu Thr
                 725                 730                 735

 ggc cat ccg ggt acc atg tag ca gttacgtcag actgggacac ttgctgttta     2261
 Gly His Pro Gly Thr Met 
             740

 cgggagacta taaaacccct gccccgtcct cacttggggc tgacgccatt ttaggcctca   2321

 gccgtctgca cccaggtgca cattaa                                        2347




      <210> 258
      <211> 1746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1746)

      <400> 258
  atg gtc tat gaa acc aag agg tgc aat gag aca agg gag aat gct ttt      48
  Met Val Tyr Glu Thr Lys Arg Cys Asn Glu Thr Arg Glu Asn Ala Phe
    1               5                  10                  15

 ctg gaa gct gga aat aac acc atg gat atc aac tgt gct gat gct tta       96
 Leu Glu Ala Gly Asn Asn Thr Met Asp Ile Asn Cys Ala Asp Ala Leu
              20                  25                  30

 aaa gga aac cta aga gat tgg aaa aca aat gtt ctc tac aag gtc cag      144
 Lys Gly Asn Leu Arg Asp Trp Lys Thr Asn Val Leu Tyr Lys Val Gln
          35                  40                  45

 aga gta aat atg tta ggc ctt ttg ttc cag atg acc ttt gtc ata act      192
 Arg Val Asn Met Leu Gly Leu Leu Phe Gln Met Thr Phe Val Ile Thr
      50                  55                  60

 act cag ctc tgc cat cag agt gtg aaa gca gcc att gat gat gtg tca      240
 Thr Gln Leu Cys His Gln Ser Val Lys Ala Ala Ile Asp Asp Val Ser
  65                  70                  75                  80

 gtg aag gat aaa cga aaa ggg atg cag gaa gta aaa ctg aac tct tac      288
 Val Lys Asp Lys Arg Lys Gly Met Gln Glu Val Lys Leu Asn Ser Tyr
                  85                  90                  95

 gtt gtg agc ggc acc gtc ggt ttg aag gaa aaa att tcc ctc tct gaa      336
 Val Val Ser Gly Thr Val Gly Leu Lys Glu Lys Ile Ser Leu Ser Glu
             100                 105                 110

 cct gtg ttc ctg act ttt cgc cat aat cag cct ggt gac aag aga aca      384
 Pro Val Phe Leu Thr Phe Arg His Asn Gln Pro Gly Asp Lys Arg Thr
         115                 120                 125

 aaa cat atc tgt gtc tac tgg gag gga tca gag gga ggc cac tgg tcc      432
 Lys His Ile Cys Val Tyr Trp Glu Gly Ser Glu Gly Gly His Trp Ser
     130                 135                 140

 acg gag ggc tgc tct cat gtg cac agc aac ggt tct tac acc aaa tgc      480
 Thr Glu Gly Cys Ser His Val His Ser Asn Gly Ser Tyr Thr Lys Cys
 145                 150                 155                 160

 aag tgc ttc cat ctg tcc agc ttt gcc gtc ctc gtg gct ctt gcc ccc      528
 Lys Cys Phe His Leu Ser Ser Phe Ala Val Leu Val Ala Leu Ala Pro
                 165                 170                 175

 aag gag gac cct gtg ctg acc gtg atc acc cag gtg ggg ctg acc atc      576
 Lys Glu Asp Pro Val Leu Thr Val Ile Thr Gln Val Gly Leu Thr Ile
             180                 185                 190

 tct ctg ctg tgc ctc ttc ctg gcc atc ctc acc ttc ctc ctg tgc cgg      624
 Ser Leu Leu Cys Leu Phe Leu Ala Ile Leu Thr Phe Leu Leu Cys Arg
         195                 200                 205

 ccc atc cag aac acc agc acc tcc ctc cat cta gag ctc tcc ctc tgc      672
 Pro Ile Gln Asn Thr Ser Thr Ser Leu His Leu Glu Leu Ser Leu Cys
     210                 215                 220

 ctc ttc ctg gcc cac ctc ctg ttc ctg acg ggc atc aac aga act gag      720
 Leu Phe Leu Ala His Leu Leu Phe Leu Thr Gly Ile Asn Arg Thr Glu
 225                 230                 235                 240

 cct gag gtg ctg tgc tcc atc att gca ggg ctg ctg cac ttc ctc tac      768
 Pro Glu Val Leu Cys Ser Ile Ile Ala Gly Leu Leu His Phe Leu Tyr
                 245                 250                 255

 ctg gct tgc ttc acc tgg atg ctc ctg gaa ggg ctg cac ctc ttc ctc      816
 Leu Ala Cys Phe Thr Trp Met Leu Leu Glu Gly Leu His Leu Phe Leu
             260                 265                 270

 acc gtc agg aac ctc aag gtg gcc aac tac acc agc acg ggc aga ttc      864
 Thr Val Arg Asn Leu Lys Val Ala Asn Tyr Thr Ser Thr Gly Arg Phe
         275                 280                 285

 aag aag agg ttc atg tac cct gta ggc tac ggg atc cca gct gtg att      912
 Lys Lys Arg Phe Met Tyr Pro Val Gly Tyr Gly Ile Pro Ala Val Ile
     290                 295                 300

 att gct gtg tca gca ata gtt gga ccc cag aat tat gga aca ttt act      960
 Ile Ala Val Ser Ala Ile Val Gly Pro Gln Asn Tyr Gly Thr Phe Thr
 305                 310                 315                 320

 cac tgt tgg ctc aag ctt gat aaa gga ttc atc tgg agc ttc atg ggg     1008
 His Cys Trp Leu Lys Leu Asp Lys Gly Phe Ile Trp Ser Phe Met Gly
                 325                 330                 335

 cca gta gca gtc att atc ttg ata aac ctg gtg ttc tac ttc caa gtt     1056
 Pro Val Ala Val Ile Ile Leu Ile Asn Leu Val Phe Tyr Phe Gln Val
             340                 345                 350

 ctg tgg att ttg aga agc aaa ctt tcc tcc ctc aat aaa gaa gtt tcc     1104
 Leu Trp Ile Leu Arg Ser Lys Leu Ser Ser Leu Asn Lys Glu Val Ser
         355                 360                 365

 acc att cag gac acc aga gtc atg aca ttt aaa gcc att tct cag cta     1152
 Thr Ile Gln Asp Thr Arg Val Met Thr Phe Lys Ala Ile Ser Gln Leu
     370                 375                 380

 ttt atc ctg ggc tgt tct tgg ggc ctt ggt ttt ttt atg gtt gaa gaa     1200
 Phe Ile Leu Gly Cys Ser Trp Gly Leu Gly Phe Phe Met Val Glu Glu
 385                 390                 395                 400

 gta ggg aag acg att gga tca atc att gca tac tca ttc acc atc atc     1248
 Val Gly Lys Thr Ile Gly Ser Ile Ile Ala Tyr Ser Phe Thr Ile Ile
                 405                 410                 415

 aac acc ctt cag gga gtg ttg ctc ttt gtg gta cac tgt ctc ctt aat     1296
 Asn Thr Leu Gln Gly Val Leu Leu Phe Val Val His Cys Leu Leu Asn
             420                 425                 430

 cgc cag atc aac tcc ctt ctc ctg acc tgg acc ttg tgg atc ctg agg     1344
 Arg Gln Ile Asn Ser Leu Leu Leu Thr Trp Thr Leu Trp Ile Leu Arg
         435                 440                 445

 cag agg ctt tcc agt gtt aat gcc gaa gtc tca acg cta aaa gac acc     1392
 Gln Arg Leu Ser Ser Val Asn Ala Glu Val Ser Thr Leu Lys Asp Thr
     450                 455                 460

 agg tta ctg acc ttc aag gcc ttt gcc cag ctc ttc atc ctg ggc tgc     1440
 Arg Leu Leu Thr Phe Lys Ala Phe Ala Gln Leu Phe Ile Leu Gly Cys
 465                 470                 475                 480

 tcc tgg gtg ctg ggc att ttt cag att gga cct gtg gca ggt gtc atg     1488
 Ser Trp Val Leu Gly Ile Phe Gln Ile Gly Pro Val Ala Gly Val Met
                 485                 490                 495

 gct tac ctg ttc acc atc atc aac agc ctg cag ggg gcc ttc atc ttc     1536
 Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu Gln Gly Ala Phe Ile Phe
             500                 505                 510

 ctc atc cac tgt ctg ctc aac ggc cag gta cga gaa gaa tac aag agg     1584
 Leu Ile His Cys Leu Leu Asn Gly Gln Val Arg Glu Glu Tyr Lys Arg
         515                 520                 525

 tgg atc act ggg aag acg aag ccc agc tcc cag tcc cag acc tca agg     1632
 Trp Ile Thr Gly Lys Thr Lys Pro Ser Ser Gln Ser Gln Thr Ser Arg
     530                 535                 540

 atc ttg ctg tcc tcc atg cca tcc gct tcc aag acg tca att att ggc     1680
 Ile Leu Leu Ser Ser Met Pro Ser Ala Ser Lys Thr Ser Ile Ile Gly
 545                 550                 555                 560

 tac att gcc ccg aca atg gta ggg cag tgc gtc acc ttc cag atg gag     1728
 Tyr Ile Ala Pro Thr Met Val Gly Gln Cys Val Thr Phe Gln Met Glu
                 565                 570                 575

 cac ttc ctg ttc agc tga                                             1746
 His Phe Leu Phe Ser 
             580





      <210> 259
      <211> 2959
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(2680)

      <400> 259
 gactcggcgc gggcgccctc ccggccagcg gcggcagccc ctcctccccg gcgccctcag     60

 gaccccccag agacccccgg cggcggcagc ctgccttgct ctgccaggaa cc    atg     115
                                                              Met
                                                                1

 agt gag gcc cgc agg gac agc acg agc agc ctg cag cgc aag aag cca      163
 Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys Pro
               5                  10                  15

 ccc tgg cta aag ctg gac att ccc tct gcg gtg ccc ctg acg gca gaa      211
 Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala Glu
          20                  25                  30

 gag ccc agc ttc ctg cag ccc ctg agg cga cag gct ttc ctg agg agt      259
 Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg Ser
      35                  40                  45

 gtg agt atg cca gcc gag aca gcc cac atc tct tca ccc cac cat gag      307
 Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His Glu
  50                  55                  60                  65

 ctc cgg cgg ccg gtg ctg caa cgc cag acg tcc atc aca cag acc atc      355
 Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr Ile
                  70                  75                  80

 cgc agg ggg acc gcc gac tgg ttt gga gtg agc aag gac agt gac agc      403
 Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp Ser
              85                  90                  95

 acc cag aaa tgg cag cgc aag agc atc cgt cac tgc agc cag cgc tac      451
 Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg Tyr
         100                 105                 110

 ggg aag ctg aag ccc cag gtc ctc cgg gag ctg gac ctg ccc agc cag      499
 Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser Gln
     115                 120                 125

 gac aac gtg tcg ctg acc agc acc gag acg cca ccc cca ctc tac gtg      547
 Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr Val
 130                 135                 140                 145

 ggg cca tgc cag ctg ggc atg cag aag atc ata gac ccc ctg gcc cgt      595
 Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala Arg
                 150                 155                 160

 ggc cgt gcc ttc cgt gtg gca gat gac act gcg gaa ggc ctg agt gcc      643
 Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser Ala
             165                 170                 175

 cca cac act ccc gtc acg ccg ggt gct gcc tcc ctc tgc tcc ttc tcc      691
 Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe Ser
         180                 185                 190

 agc tcc cgc tca ggt ttc cac cgg ctc ccg cgg cgg cgc aag cga gag      739
 Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg Glu
     195                 200                 205

 tcg gtg gcc aag atg agc ttc cgg gcg gcc gca gcg ctg atg aaa ggc      787
 Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys Gly
 210                 215                 220                 225

 cgc tcc gtt agg gat ggc acc ttt cgc cgg gca cag cgt cga agc ttc      835
 Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser Phe
                 230                 235                 240

 act cca gct agc ttt ctg gag gag gac aca act gat ttc ccc gat gag      883
 Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp Glu
             245                 250                 255

 ctg gac aca tcc ttc ttt gcc cgg gaa ggt atc ctc cat gaa gag ctg      931
 Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu Leu
         260                 265                 270

 tcc aca tac ccg gat gaa gtt ttc gag tcc cca tcg gag gca gcg cta      979
 Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala Leu
     275                 280                 285

 aag gac tgg gag aag gca ccg gag cag gcg gac ctc acc ggc ggg gcc     1027
 Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly Ala
 290                 295                 300                 305

 ctg gac cgc agc gag ctt gag cgc agc cac ctg atg ctg ccc ttg gag     1075
 Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu Glu
                 310                 315                 320

 cga ggc tgg cgg aag cag aag gag ggc gcc gca gcc ccg cag ccc aag     1123
 Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro Lys
             325                 330                 335

 gtg cgg ctc cga cag gag gtg gtg agc acc gcg ggg ccg cga cgg ggc     1171
 Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg Gly
         340                 345                 350

 cag cgt atc gcg gtg ccg gtg cgc aag ctc ttc gcc cgg gag aag cgg     1219
 Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys Arg
     355                 360                 365

 ccg tat ggg ctg ggc atg gtg gga cgg ctc acc aac cgc acc tac cgc     1267
 Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr Arg
 370                 375                 380                 385

 aag cgc atc gac agc ttc gtc aag cgc cag atc gag gac atg gac gac     1315
 Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp Asp
                 390                 395                 400

 cac agg ccc ttc ttc acc tac tgg ctt acc ttc gtg cac tcg ctc gtc     1363
 His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu Val
             405                 410                 415

 gcc atc cta gcc gtg tgc atc tat ggc atc gcg ccc gtg ggc ttc tcg     1411
 Ala Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe Ser
         420                 425                 430

 cag cat gag acg gtg gac tcg gtg ctg cgg aac cgc ggg gtc tac gag     1459
 Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr Glu
     435                 440                 445

 aac gtc aag tac gtg cag cag gag aac ttc tgg atc ggg ccc agc tcg     1507
 Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser Ser
 450                 455                 460                 465

 gag gcc ctc atc cac ctg ggc gcc aag ttt tcg ccc tgc atg cgc cag     1555
 Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg Gln
                 470                 475                 480

 gac ccg cag gtg cac agc ttc att cgc tcg gcg cgc gag cgc gag aag     1603
 Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu Lys
             485                 490                 495

 cac tcc gcc tgc tgc gtg cgc aac gac agg tcg ggc tgc gtg cag acc     1651
 His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln Thr
         500                 505                 510

 tcg gag gag gag tgc tcg tcc acg ctg gca gtg tgg gtg aag tgg ccc     1699
 Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp Pro
     515                 520                 525

 atc cat ccc agc gcc cca gag ctt gcg ggc cac aag aga cag ttt ggc     1747
 Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe Gly
 530                 535                 540                 545

 tct gtc tgc cac cag gat ccc agg gtg tgt gat gag ccc tcc tcc gaa     1795
 Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser Glu
                 550                 555                 560

 gac cct cat gag tgg cca gaa gac atc acc aag tgg ccg atc tgc acc     1843
 Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys Thr
             565                 570                 575

 aaa aac agc gct ggg aac cac acc aac cat ccc cac atg gac tgt gtc     1891
 Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys Val
         580                 585                 590

 atc aca gga cgg ccc tgc tgc att ggc acc aag ggc agg tgt gag atc     1939
 Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu Ile
     595                 600                 605

 acc tcc cgg gag tac tgt gac ttc atg agg ggc tac ttc cat gag gag     1987
 Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu Glu
 610                 615                 620                 625

 gcc acg ctc tgc tct cag gtg cac tgc atg gat gat gtg tgt ggg ctc     2035
 Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly Leu
                 630                 635                 640

 ctg cct ttt ctc aac ccc gag gtg cct gac cag ttc tac cgc ctg tgg     2083
 Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu Trp
             645                 650                 655

 cta tcc ctc ttc ctg cac gcc ggg atc ttg cac tgc ctg gtg tcc atc     2131
 Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser Ile
         660                 665                 670

 tgc ttc cag atg act gtc ctg cgg gac ctg gag aag ctg gca ggc tgg     2179
 Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly Trp
     675                 680                 685

 cac cgc ata gcc atc atc tac ctg ctg agt ggt gtc acc ggc aac ctg     2227
 His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn Leu
 690                 695                 700                 705

 gcc agt gcc atc ttc ctg cca tac cga gca gag gtg ggt cct gct ggc     2275
 Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala Gly
                 710                 715                 720

 tcc cag ttc ggc atc ctg gcc tgc ctc ttc gtg gag ctc ttc cag agc     2323
 Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln Ser
             725                 730                 735

 tgg cag atc ctg gcg cgg ccc tgg cgt gcc ttc ttc aag ctg ctg gct     2371
 Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu Ala
         740                 745                 750

 gtg gtg ctc ttc ctc ttc acc ttt ggg ctg ctg ccg tgg att gac aac     2419
 Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp Asn
     755                 760                 765

 ttt gcc cac atc tcg ggg ttc atc agt ggc ctc ttc ctc tcc ttc gcc     2467
 Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe Ala
 770                 775                 780                 785

 ttc ttg ccc tac atc agc ttt ggc aag ttc gac ctg tac cgg aaa cgc     2515
 Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys Arg
                 790                 795                 800

 tgc cag atc atc atc ttt cag gtg gtc ttc ctg ggc ctc ctg gct ggc     2563
 Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala Gly
             805                 810                 815

 ctg gtg gtc ctc ttc tac gtc tat cct gtc cgc tgt gag tgg tgt gag     2611
 Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys Glu
         820                 825                 830

 ttc ctc acc tgc atc ccc ttc act gac aag ttc tgt gag aag tac gaa     2659
 Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr Glu
     835                 840                 845

 ctg gac gct cag ctc cac tga gc tggctgcggg ctccagcggc cgtgtgctcc     2712
 Leu Asp Ala Gln Leu His 
 850                 855

 agcaggccag agccagacac gacctccctg agcctcacag gcttacagga gtcacctgct   2772

 ccatgtgggg actggcctgt ttcctgaaca cagacctctt tcttgtgcct tgttcacttc   2832

 tgttgaaccc ctcgtactgc cgggcattta ttatactact tcctgtcata accttctaac   2892

 ttgtttcttg acgaccacct catgtggcca ataaatgaac tgggagcgtt ttaaaaaaaa   2952

 aaaaaaa                                                             2959




      <210> 260
      <211> 3028
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (113)..(2749)

      <400> 260
 gactcggcgc gggcgccctc ccggccagcg gcggcagccc ctcctccccg gcgccctcag     60

 gaccccccag agacccccgg cggcggcagc ctgccttgct ctgccaggaa cc    atg     115
                                                              Met
                                                                1

 agt gag gcc cgc agg gac agc acg agc agc ctg cag cgc aag aag cca      163
 Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys Pro
               5                  10                  15

 ccc tgg cta aag ctg gac att ccc tct gcg gtg ccc ctg acg gca gaa      211
 Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala Glu
          20                  25                  30

 gag ccc agc ttc ctg cag gta ggc cct ggc ctg cag gga ctg tgg gtg      259
 Glu Pro Ser Phe Leu Gln Val Gly Pro Gly Leu Gln Gly Leu Trp Val
      35                  40                  45

 ccc cct gtc cag tac cct cac cat gac cct gtt gcc cag ccc ctg agg      307
 Pro Pro Val Gln Tyr Pro His His Asp Pro Val Ala Gln Pro Leu Arg
  50                  55                  60                  65

 cga cag gct ttc ctg agg agt gtg agt atg cca gcc gag aca gcc cac      355
 Arg Gln Ala Phe Leu Arg Ser Val Ser Met Pro Ala Glu Thr Ala His
                  70                  75                  80

 atc tct tca ccc cac cat gag ctc cgg cgg ccg gtg ctg caa cgc cag      403
 Ile Ser Ser Pro His His Glu Leu Arg Arg Pro Val Leu Gln Arg Gln
              85                  90                  95

 acg tcc atc aca cag acc atc cgc agg ggg acc gcc gac tgg ttt gga      451
 Thr Ser Ile Thr Gln Thr Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly
         100                 105                 110

 gtg agc aag gac agt gac agc acc cag aaa tgg cag cgc aag agc atc      499
 Val Ser Lys Asp Ser Asp Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile
     115                 120                 125

 cgt cac tgc agc cag cgc tac ggg aag ctg aag ccc cag gtc ctc cgg      547
 Arg His Cys Ser Gln Arg Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg
 130                 135                 140                 145

 gag ctg gac ctg ccc agc cag gac aac gtg tcg ctg acc agc acc gag      595
 Glu Leu Asp Leu Pro Ser Gln Asp Asn Val Ser Leu Thr Ser Thr Glu
                 150                 155                 160

 acg cca ccc cca ctc tac gtg ggg cca tgc cag ctg ggc atg cag aag      643
 Thr Pro Pro Pro Leu Tyr Val Gly Pro Cys Gln Leu Gly Met Gln Lys
             165                 170                 175

 atc ata gac ccc ctg gcc cgt ggc cgt gcc ttc cgt gtg gca gat gac      691
 Ile Ile Asp Pro Leu Ala Arg Gly Arg Ala Phe Arg Val Ala Asp Asp
         180                 185                 190

 act gcg gaa ggc ctg agt gcc cca cac act ccc gtc acg ccg ggt gct      739
 Thr Ala Glu Gly Leu Ser Ala Pro His Thr Pro Val Thr Pro Gly Ala
     195                 200                 205

 gcc tcc ctc tgc tcc ttc tcc agc tcc cgc tca ggt ttc cac cgg ctc      787
 Ala Ser Leu Cys Ser Phe Ser Ser Ser Arg Ser Gly Phe His Arg Leu
 210                 215                 220                 225

 ccg cgg cgg cgc aag cga gag tcg gtg gcc aag atg agc ttc cgg gcg      835
 Pro Arg Arg Arg Lys Arg Glu Ser Val Ala Lys Met Ser Phe Arg Ala
                 230                 235                 240

 gcc gca gcg ctg atg aaa ggc cgc tcc gtt agg gat ggc acc ttt cgc      883
 Ala Ala Ala Leu Met Lys Gly Arg Ser Val Arg Asp Gly Thr Phe Arg
             245                 250                 255

 cgg gca cag cgt cga agc ttc act cca gct agc ttt ctg gag gag gac      931
 Arg Ala Gln Arg Arg Ser Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp
         260                 265                 270

 aca act gat ttc ccc gat gag ctg gac aca tcc ttc ttt gcc cgg gaa      979
 Thr Thr Asp Phe Pro Asp Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu
     275                 280                 285

 ggt atc ctc cat gaa gag ctg tcc aca tac ccg gat gaa gtt ttc gag     1027
 Gly Ile Leu His Glu Glu Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu
 290                 295                 300                 305

 tcc cca tcg gag gca gcg cta aag gac tgg gag aag gca ccg gag cag     1075
 Ser Pro Ser Glu Ala Ala Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln
                 310                 315                 320

 gcg gac ctc acc ggc ggg gcc ctg gac cgc agc gag ctt gag cgc agc     1123
 Ala Asp Leu Thr Gly Gly Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser
             325                 330                 335

 cac ctg atg ctg ccc ttg gag cga ggc tgg cgg aag cag aag gag ggc     1171
 His Leu Met Leu Pro Leu Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly
         340                 345                 350

 gcc gca gcc ccg cag ccc aag gtg cgg ctc cga cag gag gtg gtg agc     1219
 Ala Ala Ala Pro Gln Pro Lys Val Arg Leu Arg Gln Glu Val Val Ser
     355                 360                 365

 acc gcg ggg ccg cga cgg ggc cag cgt atc gcg gtg ccg gtg cgc aag     1267
 Thr Ala Gly Pro Arg Arg Gly Gln Arg Ile Ala Val Pro Val Arg Lys
 370                 375                 380                 385

 ctc ttc gcc cgg gag aag cgg ccg tat ggg ctg ggc atg gtg gga cgg     1315
 Leu Phe Ala Arg Glu Lys Arg Pro Tyr Gly Leu Gly Met Val Gly Arg
                 390                 395                 400

 ctc acc aac cgc acc tac cgc aag cgc atc gac agc ttc gtc aag cgc     1363
 Leu Thr Asn Arg Thr Tyr Arg Lys Arg Ile Asp Ser Phe Val Lys Arg
             405                 410                 415

 cag atc gag gac atg gac gac cac agg ccc ttc ttc acc tac tgg ctt     1411
 Gln Ile Glu Asp Met Asp Asp His Arg Pro Phe Phe Thr Tyr Trp Leu
         420                 425                 430

 acc ttc gtg cac tcg ctc gtc gcc atc cta gcc gtg tgc atc tat ggc     1459
 Thr Phe Val His Ser Leu Val Ala Ile Leu Ala Val Cys Ile Tyr Gly
     435                 440                 445

 atc gcg ccc gtg ggc ttc tcg cag cat gag acg gtg gac tcg gtg ctg     1507
 Ile Ala Pro Val Gly Phe Ser Gln His Glu Thr Val Asp Ser Val Leu
 450                 455                 460                 465

 cgg aac cgc ggg gtc tac gag aac gtc aag tac gtg cag cag gag aac     1555
 Arg Asn Arg Gly Val Tyr Glu Asn Val Lys Tyr Val Gln Gln Glu Asn
                 470                 475                 480

 ttc tgg atc ggg ccc agc tcg gag gcc ctc atc cac ctg ggc gcc aag     1603
 Phe Trp Ile Gly Pro Ser Ser Glu Ala Leu Ile His Leu Gly Ala Lys
             485                 490                 495

 ttt tcg ccc tgc atg cgc cag gac ccg cag gtg cac agc ttc att cgc     1651
 Phe Ser Pro Cys Met Arg Gln Asp Pro Gln Val His Ser Phe Ile Arg
         500                 505                 510

 tcg gcg cgc gag cgc gag aag cac tcc gcc tgc tgc gtg cgc aac gac     1699
 Ser Ala Arg Glu Arg Glu Lys His Ser Ala Cys Cys Val Arg Asn Asp
     515                 520                 525

 agg tcg ggc tgc gtg cag acc tcg gag gag gag tgc tcg tcc acg ctg     1747
 Arg Ser Gly Cys Val Gln Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu
 530                 535                 540                 545

 gca gtg tgg gtg aag tgg ccc atc cat ccc agc gcc cca gag ctt gcg     1795
 Ala Val Trp Val Lys Trp Pro Ile His Pro Ser Ala Pro Glu Leu Ala
                 550                 555                 560

 ggc cac aag aga cag ttt ggc tct gtc tgc cac cag gat ccc agg gtg     1843
 Gly His Lys Arg Gln Phe Gly Ser Val Cys His Gln Asp Pro Arg Val
             565                 570                 575

 tgt gat gag ccc tcc tcc gaa gac cct cat gag tgg cca gaa gac atc     1891
 Cys Asp Glu Pro Ser Ser Glu Asp Pro His Glu Trp Pro Glu Asp Ile
         580                 585                 590

 acc aag tgg ccg atc tgc acc aaa aac agc gct ggg aac cac acc aac     1939
 Thr Lys Trp Pro Ile Cys Thr Lys Asn Ser Ala Gly Asn His Thr Asn
     595                 600                 605

 cat ccc cac atg gac tgt gtc atc aca gga cgg ccc tgc tgc att ggc     1987
 His Pro His Met Asp Cys Val Ile Thr Gly Arg Pro Cys Cys Ile Gly
 610                 615                 620                 625

 acc aag ggc agg tgt gag atc acc tcc cgg gag tac tgt gac ttc atg     2035
 Thr Lys Gly Arg Cys Glu Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met
                 630                 635                 640

 agg ggc tac ttc cat gag gag gcc acg ctc tgc tct cag gtg cac tgc     2083
 Arg Gly Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val His Cys
             645                 650                 655

 atg gat gat gtg tgt ggg ctc ctg cct ttt ctc aac ccc gag gtg cct     2131
 Met Asp Asp Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val Pro
         660                 665                 670

 gac cag ttc tac cgc ctg tgg cta tcc ctc ttc ctg cac gcc ggg atc     2179
 Asp Gln Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala Gly Ile
     675                 680                 685

 ttg cac tgc ctg gtg tcc atc tgc ttc cag atg act gtc ctg cgg gac     2227
 Leu His Cys Leu Val Ser Ile Cys Phe Gln Met Thr Val Leu Arg Asp
 690                 695                 700                 705

 ctg gag aag ctg gca ggc tgg cac cgc ata gcc atc atc tac ctg ctg     2275
 Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Tyr Leu Leu
                 710                 715                 720

 agt ggt gtc acc ggc aac ctg gcc agt gcc atc ttc ctg cca tac cga     2323
 Ser Gly Val Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg
             725                 730                 735

 gca gag gtg ggt cct gct ggc tcc cag ttc ggc atc ctg gcc tgc ctc     2371
 Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu
         740                 745                 750

 ttc gtg gag ctc ttc cag agc tgg cag atc ctg gcg cgg ccc tgg cgt     2419
 Phe Val Glu Leu Phe Gln Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg
     755                 760                 765

 gcc ttc ttc aag ctg ctg gct gtg gtg ctc ttc ctc ttc acc ttt ggg     2467
 Ala Phe Phe Lys Leu Leu Ala Val Val Leu Phe Leu Phe Thr Phe Gly
 770                 775                 780                 785

 ctg ctg ccg tgg att gac aac ttt gcc cac atc tcg ggg ttc atc agt     2515
 Leu Leu Pro Trp Ile Asp Asn Phe Ala His Ile Ser Gly Phe Ile Ser
                 790                 795                 800

 ggc ctc ttc ctc tcc ttc gcc ttc ttg ccc tac atc agc ttt ggc aag     2563
 Gly Leu Phe Leu Ser Phe Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys
             805                 810                 815

 ttc gac ctg tac cgg aaa cgc tgc cag atc atc atc ttt cag gtg gtc     2611
 Phe Asp Leu Tyr Arg Lys Arg Cys Gln Ile Ile Ile Phe Gln Val Val
         820                 825                 830

 ttc ctg ggc ctc ctg gct ggc ctg gtg gtc ctc ttc tac gtc tat cct     2659
 Phe Leu Gly Leu Leu Ala Gly Leu Val Val Leu Phe Tyr Val Tyr Pro
     835                 840                 845

 gtc cgc tgt gag tgg tgt gag ttc ctc acc tgc atc ccc ttc act gac     2707
 Val Arg Cys Glu Trp Cys Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp
 850                 855                 860                 865

 aag ttc tgt gag aag tac gaa ctg gac gct cag ctc cac tga gctggct     2756
 Lys Phe Cys Glu Lys Tyr Glu Leu Asp Ala Gln Leu His 
                 870                 875

 gcgggctcca gcggccgtgt gctccagcag gccagagcca gacacgacct ccctgagcct   2816

 cacaggctta caggagtcac ctgctccatg tggggactgg cctgtttcct gaacacagac   2876

 ctctttcttg tgccttgttc acttctgttg aacccctcgt actgccgggc atttattata   2936

 ctacttcctg tcataacctt ctaacttgtt tcttgacgac cacctcatgt ggccaataaa   2996

 tgaactggga gcgttttaaa aaaaaaaaaa aa                                 3028




      <210> 261
      <211> 1123
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (346)..(999)

      <400> 261
 aagaggaaac tgggcacaga gaggcccggc acccaggcag cccctaaacg gagatggtct     60

 gcatctgcag gcgcggggaa aggcatagca ggcagcgccc tgaacaaatc agaaaaacag    120

 ccttcggctc tggagcccac tccggcacgg cctcaggtgc tctaccccgc gggatccagg    180

 gagtggccgc cactcacagt tgcccctcct gtccgctccg gtccgctccc gccgcccgag    240

 gtccgcgacg ccccgcccag tgggtggagt gtgaggcggg gaggtcgctc gactcgccgg    300

 cgctgtggcc tcccgcggag ccgctcagac tttccctgcc ggcac    atg gac ctg     354
                                                      Met Asp Leu
                                                        1

 gcc caa ccc tca cag cca gta gac gag ctg gag ctc tcg gtg ctc gag      402
 Ala Gln Pro Ser Gln Pro Val Asp Glu Leu Glu Leu Ser Val Leu Glu
       5                  10                  15

 cgg cag cca gaa gag aac acg cct ctc aat ggt gcc gac aag gtc ttc      450
 Arg Gln Pro Glu Glu Asn Thr Pro Leu Asn Gly Ala Asp Lys Val Phe
  20                  25                  30                  35

 cct tct ttg gac gag gag gtc ccc ccg gcc gag gct aac aag gaa agc      498
 Pro Ser Leu Asp Glu Glu Val Pro Pro Ala Glu Ala Asn Lys Glu Ser
                  40                  45                  50

 ccc tgg agc tcc tgt aat aag aat gtg gtt gga aga tgc aaa ctg tgg      546
 Pro Trp Ser Ser Cys Asn Lys Asn Val Val Gly Arg Cys Lys Leu Trp
              55                  60                  65

 atg atc atc acc tcc att ttc cta ggt gtc att aca gtg atc atc ata      594
 Met Ile Ile Thr Ser Ile Phe Leu Gly Val Ile Thr Val Ile Ile Ile
          70                  75                  80

 ggc tta tgt ctt gct gca gta act tat gtt gat gaa gat gaa aat gaa      642
 Gly Leu Cys Leu Ala Ala Val Thr Tyr Val Asp Glu Asp Glu Asn Glu
      85                  90                  95

 ata ctt gaa tta tca tca aac aaa aca ttc ttc atc atg ctg aag att      690
 Ile Leu Glu Leu Ser Ser Asn Lys Thr Phe Phe Ile Met Leu Lys Ile
 100                 105                 110                 115

 cca gag gag tgt gtt gct gaa gag gaa ttg cct cac ctg ctc acc gaa      738
 Pro Glu Glu Cys Val Ala Glu Glu Glu Leu Pro His Leu Leu Thr Glu
                 120                 125                 130

 agg ctc aca gat gtg tac agt aca tcg ccc tct ctg agt cgt tat ttt      786
 Arg Leu Thr Asp Val Tyr Ser Thr Ser Pro Ser Leu Ser Arg Tyr Phe
             135                 140                 145

 act tca gtt gaa ata gtg gac ttc agt ggt gaa aat gcc aca gta acg      834
 Thr Ser Val Glu Ile Val Asp Phe Ser Gly Glu Asn Ala Thr Val Thr
         150                 155                 160

 tat gac ctg caa ttt ggg gtt cca tca gat gat gaa aat ttt atg aag      882
 Tyr Asp Leu Gln Phe Gly Val Pro Ser Asp Asp Glu Asn Phe Met Lys
     165                 170                 175

 tat atg atg agt gag gag ttg gtg ctg ggc att ttg cta cag gat ttc      930
 Tyr Met Met Ser Glu Glu Leu Val Leu Gly Ile Leu Leu Gln Asp Phe
 180                 185                 190                 195

 cgt gat cag aat ata cct ggt tgt gag agt ctg ggg ctt gat cca aca      978
 Arg Asp Gln Asn Ile Pro Gly Cys Glu Ser Leu Gly Leu Asp Pro Thr
                 200                 205                 210

 tcc ctc ttg ctc tat gaa tga ag tgatggaggc tggtctctgt ctgaaagcag     1031
 Ser Leu Leu Leu Tyr Glu 
             215

 tgctctacca agtcctggag atgaagggaa ttcactctgt tttgcagaaa agattctgtg   1091

 gattaataca gaagcaccag caacaccaga gg                                 1123




      <210> 262
      <211> 16578
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5098)..(6036)

      <400> 262
 gaattcattg ctagcagacc cactttacaa gaaatactaa aagaaatcct ctaggctgaa     60

 agcaagcaaa tacagacgga aattcaaatc cacatgatag aacaaagagc actgataaag    120

 gtaattatat aattataaaa ggcagtttta agtgcatatt tcttatttct tctcctattt    180

 ttcaaagaaa tcatataaaa caatatgtat ataattatat tcttggaaaa aatgtatact    240

 ctaaaaatta caaaatattg ttgaaagaaa ttaaagaaga tccgactggc tcattggcgc    300

 tgtcatggca ggtgtgctga agaagaccac tggcctcatg ggattggctg tatgcaagag    360

 tccacacaag acaagcaact aaaatcagtc tgctaaaatg taagaggcta agaatattgt    420

 acacaaagat ccttgatgtt cttaagcaaa ccccttaaaa agcagcacat agaaagtata    480

 cagaacagat tgcagatgag aaattggcta tggttaaagc agaaccagat gttaaaaaat    540

 tagaagacca acttcaaggt gttcaaataa aagaggtgat tcttcaggct gaaaatgaac    600

 taagtctggc aagaaaaatg atacagtgga aatgatagga gatgttcatg gaagagcctc    660

 ctgccaatca atggaaatgg ccaatgtaat taataaatga ctggtgggtt gatgggaaaa    720

 ataatataat taaatattct gttatattaa gagcatgccc atattattga cattttataa    780

 tcaagaaaag taatatagaa aatgtttaag agacttaaaa ttagtgatta tggtagtaca    840

 gtattgtgaa tcaatttttg atttgtaaag tattcacaca aattattaca aagatgatat    900

 ttcttagaac agagaggtca tggaaagact tgaaaattaa ttttaaaaaa tcctacagat    960

 cttcaatgca gaggccatac tccaaaagta aagtttcttt agtagtatct tcaatacatc   1020

 attaattttt ttatcattct gaagaagaaa aggtccttaa ttattattgt ctaaacaaat   1080

 ttatagatca ctgtttaaag taaatatagt aagagtgaat attttcaaat gtgataaaat   1140

 agcacaagtg gctggtaata aaatttgaaa ttatagttaa cctccttggc tgtgatctta   1200

 cgtatgtaaa gtaaaatgta aatacataat taggccaggt gcagtggctc acacctgtaa   1260

 tcctagcact ttgggaggcc gaggcagttg gatcatttga gatcagaagt ttgagaccag   1320

 cctagccaac atggtgaaac cccatctcta ccaaaaatac acaaaaatta cctgggtatg   1380

 atggtgtgtg cttgtgatcc cagctactcg ggaggctgag gtgggaggat cacttgagcc   1440

 caaaaggcag aagttgcagt gagcccaggt cacactactg caccccagcc tgggtatcag   1500

 agcgaaaccc catctcaaag aaaaaaaatt aaaattaaaa taggctaaag agcctatttt   1560

 tttctccaaa gaagatatac aaatacccaa tgagcacttg aaaatatgtt caatgtcatt   1620

 agccattaga gaaatgcaaa tcaaaatcac aattagatac cacttcactc ttactatgat   1680

 ggttatatat aaatataaat tttttttttg agacagggtc tcactctgtc acccaggctg   1740

 gagtagggtg gtatgaacat ggctcacagc agccctcaac cttctgggct caagctattc   1800

 tcctgcctca atctcccaag tagcggagac tacaggcaca tgccaccatg cccggctaat   1860

 ttttgtattt tttgtagaga cgaggtttca ccatgttgcc cgggctggtc tcgaactcct   1920

 ggtctcaagt gatctgccca cctcggcctc ccaaagtgct gggattacag gcgtgagcca   1980

 ccacacccaa ccaagatggc tataatttaa aaagcagata ataacaattg ttggtgagga   2040

 tgtggagaaa ttgaaaccct cacatattgg ggaaatgtaa aatgggaaag taaaatgata   2100

 ctttccattt tggaaactgg cagttcccca aaaatataca catagagttt ctatatgacc   2160

 tagaaactcc actcctaaga aaatatccaa gaaaaatgaa aatatacatc cacacaaaaa   2220

 cttgtatgca aatgttcata gcagcactat tcgtaacagt caaaaagtgg aatcaaccca   2280

 aatgtctatc aactgatgaa tgggcacata aaatgtggta tatccataca actgaatatt   2340

 aattagcaat aaaaagaaag taagtcctga tacatgctac aatatagatg aaccttgaaa   2400

 acattaagct aagtaagaga aaccagtcac aaagggaaac atattttata atttcattta   2460

 tgtaaaatgt ccagaatagg cagctcaaaa gagacaaaaa gtagattaat ggtttcctaa   2520

 gactggagga ggttgagggg aaaaggggag tgatggctaa agggtatggg cttcctttgg   2580

 aagtgataaa catgttctaa aatcaactgt ggtgatactc aaaactattg cattgtacac   2640

 tttaaattca cccgttgtac actttaaact cacccattta aagtgtacaa tgcaatagtt   2700

 ttgtatttga attgtacatt ttaaatgggt gaatttaaat gggcggctgc atggtgtttg   2760

 aattatagct caataaagat gctattttta aaaagaacta accattgatt cacacaacat   2820

 ggatgactct caaaataatc acgctgagtg aaagaagcca gattttaaaa agagtacatt   2880

 ctgcataatt ccctttatgt aaaatgctag aaaatgaaag taatctacag ttacagagag   2940

 caaatcagtg gctgcctggt tggggaagaa aggaatggat taccaagggg catgagaaaa   3000

 attgtgggta tattagataa gttcattatc ttgattgtgg tcatggtttc atgactgtat   3060

 acattaaaac taatcaaatt atatgattta aatatagttg tacatcaacc atccttcaat   3120

 aaagctgcaa caaaaaagca tactaaaaag tcacaagacc tatttccatg tatagatata   3180

 catatgcaaa tggccagaaa agtatctgga tagatataca caaaactaat aacaatagtt   3240

 acttttggaa aagtgggaga gtgggaaggg tgggtgaggc tgggtatgga agagtgaggg   3300

 aagggtgagg ctgggtatgg gagagtggga agggtgggtg aggctgggta tgggagagtg   3360

 gggggagggt gagtctgggt atgggagagt gggaagggtg ggtgaggctg ggtatggaag   3420

 agtcagggga gggggaggct gggtatggga gggtggggga ggacaaggat gggtatggga   3480

 gagtgggagg ggtgggtgag gctgggtacg gaagagtggg gggacggtga ggctgggtat   3540

 ggaagacttg ggggtcctct ctgcctagga agggtttgca ctcagcagcc tgggagcaca   3600

 cctgtcatca gtgctccctc acatctggca ccacctgaca tgtagcaggt cctcagttac   3660

 ttctaggttc tgggatgagt aagtgagggt ggaataaaag acggaaatgg tctcctgcaa   3720

 ggaaggcact gagaggaact gtgctccacc caggcccagg atttggcatc gtgtcccatg   3780

 ggattaatga caccgtgcca gataccctgg aacactaagg agaggtgact catgctcttt   3840

 tgctggtgag aggattgtgg cagcacctgg ggcactgata tccatctaga atggtaaaag   3900

 aacaagcatt gtttgaaacc taatagaagc atacacctgc tctgagcatg gtataggggt   3960

 cacactgttg ggagggctgg attctagctt cacctcacca gagacctgtt gtgtgacctc   4020

 agcatcccca tctatacaat gggagatcca acaagttggc ctctggtcat gttccatgct   4080

 aataccctag gagttcatga agtcaaagca gccctcgctc tggcccacag aacatagggg   4140

 tttggagctg ggccaaaagc tccatcagat tttagctggg aaacccacag gaaggcagat   4200

 tgtgaaggtc caatccacac agggtagcta atgaaacagg ccctgggcag gggacagggg   4260

 aacatgccca gcgataggct tcaaggtcag cagccctcca acacacagca cggtgtatgc   4320

 tttgttcatg gatactagag taggcctgaa gagacaggtc agaccactgc aggccgagga   4380

 cattccagac agaaggaata gcaaatgcga tggctcagag gcttccttaa agccaggaga   4440

 atctccacct gctcagagac cacctagccc actagttcct caaagtgtgg tacctacatc   4500

 agcagcagaa gcatcgccca gacgcaccga gtcagaaact gggtttgggg cccaacaatc   4560

 tgttttaaca aactttccag gtgattctgg tgcatgttaa agtttgagaa ctgttgatct   4620

 agcctactgt ttcccagact atgctcatag aacacttatc tgcagtaggt taatgggttt   4680

 tctgtaaaag gggatccatg atcaaataag tttggggtac agatgttcta cattgctttg   4740

 caggagtcat agatcacatt agcgtagtaa acgctctgag aagtcctgca gtaaagagct   4800

 ttatttttta ttaatccaat gttgtctcaa attgattttt cagattgctt actaatgttc   4860

 tcattaacat tctctcaggg aatgctgatc taaatcaatg ctcatttttc acatggataa   4920

 actgaggcct agagaggata aagggattgc ccgacgtcac agacagtgag tgtggcagtg   4980

 ctggaaaaga tcctgacagt ccacctcgtc ccagaaaggg ctctgtgagc ttccccgcac   5040

 cctgtaccct ctctccttcc atcccagctg tggaccatct cttcagaact ctgcagc      5097                                                                 
 atg gag ccg ctc aac aga aca gag gtg tcc gag ttc ttt ctg aaa gga     5145
 Met Glu Pro Leu Asn Arg Thr Glu Val Ser Glu Phe Phe Leu Lys Gly
   1               5                  10                  15

 ttt tct ggc tac cca gcc ctg gag cat ctg ctc ttc cct ctg tgc tca     5193
 Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser
              20                  25                  30

 gcc atg tac ctg gtg acc ctc ctg ggg aac aca gcc atc atg gcg gtg     5241
 Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Met Ala Val
          35                  40                  45

 agc gtg cta gat atc cac ctg cac acg ccc gtg tac ttc ttc ctg ggc     5289
 Ser Val Leu Asp Ile His Leu His Thr Pro Val Tyr Phe Phe Leu Gly
      50                  55                  60

 aac ctc tct acc ctg gac atc tgc tac acg ccc acc ttt gtg cct ctg     5337
 Asn Leu Ser Thr Leu Asp Ile Cys Tyr Thr Pro Thr Phe Val Pro Leu
  65                  70                  75                  80

 atg ctg gtc cac ctc ctg tca tcc cgg aag acc atc tcc ttt gct gtc     5385
 Met Leu Val His Leu Leu Ser Ser Arg Lys Thr Ile Ser Phe Ala Val
                  85                  90                  95

 tgt gcc atc cag atg tgt ctg agc ctg tcc acg ggc tcc acg gag tgc     5433
 Cys Ala Ile Gln Met Cys Leu Ser Leu Ser Thr Gly Ser Thr Glu Cys
             100                 105                 110

 ctg cta ctg gcc atc acg gcc tat gac cgc tac ctg gcc atc tgc cag     5481
 Leu Leu Leu Ala Ile Thr Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gln
         115                 120                 125

 cca ctc agg tac cac gtg ctc atg agc cac cgg ctc tgc gtg ctg ctg     5529
 Pro Leu Arg Tyr His Val Leu Met Ser His Arg Leu Cys Val Leu Leu
     130                 135                 140

 atg gga gct gcc tgg gtc ctc tgc ctc ctc aag tcg gtg act gag atg     5577
 Met Gly Ala Ala Trp Val Leu Cys Leu Leu Lys Ser Val Thr Glu Met
 145                 150                 155                 160

 gtc atc tcc atg agg ctg ccc ttc tgt ggc cac cac gtg gtc agt cac     5625
 Val Ile Ser Met Arg Leu Pro Phe Cys Gly His His Val Val Ser His
                 165                 170                 175

 ttc acc tgc aag atc ctg gca gtg ctg aag ctg gca tgc ggc aac acg     5673
 Phe Thr Cys Lys Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asn Thr
             180                 185                 190

 tcg gtc agc gaa gac ttc ctg ctg gcg ggc tcc atc ctg ctg ctg cct     5721
 Ser Val Ser Glu Asp Phe Leu Leu Ala Gly Ser Ile Leu Leu Leu Pro
         195                 200                 205

 gta ccc ctg gca ttc atc tgc ctg tcc tac ttg ctc atc ctg gcc acc     5769
 Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Leu Leu Ile Leu Ala Thr
     210                 215                 220

 atc ctg agg gtg ccc tcg gcc gcc agg tgc tgc aaa gcc ttc tcc acc     5817
 Ile Leu Arg Val Pro Ser Ala Ala Arg Cys Cys Lys Ala Phe Ser Thr
 225                 230                 235                 240

 tgc ttg gca cac ctg gct gta gtg ctg ctt ttc tac ggc acc atc atc     5865
 Cys Leu Ala His Leu Ala Val Val Leu Leu Phe Tyr Gly Thr Ile Ile
                 245                 250                 255

 ttc atg tac ttg aag ccc aag agt aag gaa gcc cac atc tct gat gag     5913
 Phe Met Tyr Leu Lys Pro Lys Ser Lys Glu Ala His Ile Ser Asp Glu
             260                 265                 270

 gtc ttc aca gtc ctc tat gcc atg gtc acg acc atg ctg aac ccc acc     5961
 Val Phe Thr Val Leu Tyr Ala Met Val Thr Thr Met Leu Asn Pro Thr
         275                 280                 285

 atc tac agc ctg agg aac aag gag gtg aag gag gcc gcc agg aag gtg     6009
 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ala Arg Lys Val
     290                 295                 300

 tgg ggc agg agt cgg gcc tcc agg tga gggag ggcggggctc tgtacagacg     6061
 Trp Gly Arg Ser Arg Ala Ser Arg 
 305                 310

 caggtctcag gttagtagct gaggccatcg tatgccaatg ccagtgaaga catggcaggg   6121

 ctggggctac aggtctggta tcttcatccc agcaaggcag caccaagtcc cgctgatcct   6181

 gccacagaac agcccccaaa tcaccctctg ctctcagcat caccctggcc ttcacaccag   6241

 cctcctggct ggtcccaaga cttcagtcct gttcctccct ccaatctctc cttcatgggg   6301

 catctttttg aaatgcacat gtgattgcat cactcttctc actgaaatcc ctaggtggct   6361

 ccccactgtt ctcagaacaa agtggaagct tttcagtggg gcatttgagg ccctcacaag   6421

 ctggccctgc ctgactggct ccccagcctt cctcccctcc caccccatct ccctcctcac   6481

 agccacacac accagccagt tgtggccccc acatgccctg caccacccag ctctgtgctc   6541

 tccttgtttc tccccacgag gcagcacccc ctcccctatc cccagcacac ttctccatat   6601

 gtaaaaggac tgactgcctg acccttcagg cccagctcaa atgccacctc caccaggaag   6661

 ccaccccacc ttgctcctct tgctgtgccc ctctgtgttt tcagcattac tccaagagca   6721

 gggagtgtca gattctactc tctcccaagg tccagccttg cccaactcta ggccctgcac   6781

 aagtttctta aatagagata ttaacatgtc aatgtagggg tgacaatggc agagcctaga   6841

 gttcttccca aaactgagca gagctgagac ggagtccaca gatgacgaga atggcccagc   6901

 ttccctggta ggtgacagta gaggcagcaa tgaggcctgt attagtcagg gttctcttag   6961

 agggacagaa ctaataggat agaggagttt attaagtatt aacttacacg atcacaaggt   7021

 tccacaatag gctgaggagc aaggagaacc agtccgagtc cccagactga agaacttgga   7081

 gtccattgtt caagggacgg aaacatccag catgggagaa agatgtaggc tcggaggcta   7141

 ggcccgtctc tccttttcac gtttttctgc ctgctttata ttcactggaa actgattaga   7201

 tcatgcccac cagattaggg tggatctgcc ttccccagcc cactgactca aatgtgaatc   7261

 tcttttggca acacccacac agaacacacc caggattcat actttgtatc ccacgatcca   7321

 aagaagttga cactcagtat taaccatcac aaggcccaaa gtccaagatt cccagacctg   7381

 tcaggccctg ggacaccaat catccagccc aaagcctgaa gccaccccat tcctcccacc   7441

 tcaccccgcc cagcagcaac agcagcagca gcagcttcca gtgctccctt tcttgggatc   7501

 caggcctcac ctggcttgag gaagcttgtt ttacccatcc tcacctcatg ccctgggacc   7561

 ctgccatagt tgcccctgcc tggtgctcag cctcttccag cttttctttc tgataactca   7621

 gtgcacaggc agtggacact gacctagatt cacggagcat ttccattccc tgccttgccc   7681

 tggcctccat ggtaccatct gtacgatggg agcactgggc ttgccctgca agcagcagtc   7741

 cacctttcct gcccccggct acaggtaagc acagcccctg catgaggcct gaattcccct   7801

 cccagggctt tctccctgct tcctctgctg gccagaacag aggcacagag aagcatggct   7861

 agaggagtga gagataccca agcctctctg accacgcctg agagaaggct gccagtagcc   7921

 atgccagtgg ccatgccatt ctgctgggcc atggatacat cacagaggtt tgggttttat   7981

 tctgtgggct ctgggggttt acaatcagat tgacttttag caaggtcact gattagatac   8041

 cattctctct cttgtttaac acaatgtcca ctgttaggta ccatgtggtg aagtaggcag   8101

 tgtcatacac tgctggtgga aatggggata atttaatatg aacttcctag aaagtaagtt   8161

 ggaaatatga atcaagggcc ttcaaaactt ccagacccct tgacccaaca cctctacttc   8221

 taggaatcca gtctaagtaa ataataaagg gcacaaagat ttggacataa ggatattaat   8281

 aacagcatta tttgtagtaa caaaaaaact gtaataatct taatgttcaa ccatagaaga   8341

 atatttaaac aaatcccggt ggagtccaat gacagtatgt gatgcagccg ttaagaatct   8401

 gttttttttt tttttttttc aagacagggt ctcactctgt tacccaggct ggaatgtagt   8461

 ggtacaatct tggctcaccg cagcctcaac ttcctgggcc caagcaattc tcccacctca   8521

 gccgtctgag gagctgggac tacatgcatg tgccaccacg tccagctaat ttatttttaa   8581

 tagagacgag gtctcgctat gttgcccagg ctggtcttga actcctgggc tcaaccgatc   8641

 ctcccaactc ggtctcccaa agtgctggga ttacaggcat gagccaccat gcctggccag   8701

 gaatcttatt ttttgaaggg tatatgataa tgggcaatac tcgtaaagta actagaaaaa   8761

 aaaaaagcag aacacataac attgtatttt agtatgatct caattttaac tttttaagta   8821

 tttttcttac agatctatga ataagtcagt atctaggaaa tactggaaaa cgatgaccaa   8881

 atattaacta acagttgttt cctttgggtg acagggttac agataagtac tgttttttaa   8941

 attattattt tcaatattat ccaatatttc tatgatgacc atgactttga acttaaaaaa   9001

 taatggtatg tggaagacca ccttgcccgc agtagacgac agatgagaaa ggcttcctcc   9061

 tgagggcagg gaagggagga agctgctgta gtcacccagg ccctcagtga ggcctgagct   9121

 ggctgggcag taaaggagag ggtggcccca agaaatattg gggagataga tatagatgca   9181

 aaataacatt tgggagctag agatataata tttgggatta cagttaaccc ctgaacaaca   9241

 cgggggtgag gggtgccaac tctcctcact gtaaaaaaaa aaatccatgt ataactgttg   9301

 actggaagcc ttatcaataa cataaagtcg attaacacat aatttgtatg ttatatgttt   9361

 tatatactgt attcttacaa taaagctaaa gaaaagagaa tgttattaag aaagtcataa   9421

 ggaagagaca tagatttcct atctattaaa cggatcatca taaaagtctt catcactgtc   9481

 aacatcatgt tgagtaggag gaggaggaag aggagggact agtcttgctg tctcaggggt   9541

 ggcggttcat ctgcaagttt tttcaaattg tagcaaatct caaaaaaaaa ttcccaatat   9601

 attttttgaa aaatacaagt ataagtgaac tcatgtagtt caaatccatg ttattcaagg   9661

 gtcaactgta tatatatgta aaataatatt tggaagatat tttgggatta tagaggtgga   9721

 ggagggagag gtgaggaccg tgggcaggtc ctgagtttct ggtttatttg gggtagactg   9781

 agacactgca tggggaggat gagcacagta gatgggggaa gtggggagat ggtgagtttg   9841

 tcttcgacct gctgagttca gggtatccgt ggggcagcaa gaggacaata tgctatgagc   9901

 agatagaaaa tcaacagtag caacttttcc attttttact tcgacctatg ttcttgataa   9961

 aaaaattcca gaagacaaat tatagcatca taggaaactt tgcaacttct gctgctttat  10021

 tgaaggatga tttttagtct ctaagctgtg tcaagttgtt attctttatt gtgaaaggac  10081

 aggaagggga ggggagggaa caggaataaa gaaatctgta aaaacagatg cctgattaaa  10141

 tccctgacct aataaagtcc ctcgcctgta ctcggtgtct cccaccttac aaagcaattt  10201

 actttaagct ttgatgaatc caggtcctta cggcaatcct ggaaggagac accccatttc  10261

 acaacccaga cacccaggcc tagtgaagcc gggcttatgg gcctggagcc tatggcatcc  10321

 aaggcgcaga actgcaacgt gacccagtat tcagattctc tgtccactct ctctcctatg  10381

 cccacttcac ctcagcaggg ccctcctggg gcaggccgag gaacctggag tctctgaagc  10441

 ccaggtccca cagctgccaa gcctgcaact ttgtgcagtt gcagagtttg aactttaaat  10501

 tgggcaggga ccatgaggtc cctgaaagca gggggcaagc agactgtcta tgtggcaggg  10561

 gagcaagagg caggtcctgg gaggcagtgg cagggcgagg tgcggggaac ctagcccatc  10621

 ccagcaccgt gcacttgctc ataatgaact cggcacttcc caaaccacag ctcccctcac  10681

 ctggctccag ctccctacag acatttaggc catggccagt aggtgagagg taaggagatt  10741

 tcatctgacc cattgcttat tctcaagaaa tcatttaaaa catttaaaag ccaaaatatt  10801

 tgctggggga cagggatagg gacaggatgg taataatatc atctactgct cactgactat  10861

 ttaccagtgc caggctctgt tctaagagct tcgcatgctt cctgtcactg gatccttaaa  10921

 acaagcccac aaggaaatac tgccgtctcc atggtatagg taaggaagct gaggctgaga  10981

 acattgttaa caagtggaag agctggggct tggaccctag tcccgtctga ctccagggcc  11041

 atcctcatct tctctgccac acagccagga agcaggaatc ccagatccag gcatttcggg  11101

 gaaattgtaa ccgaagcttt cttcttgtta tgcccctatc ttttctttta aaataatttg  11161

 tgaagcctaa aataagtatt aagtggttaa aattagattt accagacaat gagactgata  11221

 tgtcagttag cttgcaaagt aaccctgggt ctatcagacc tcaggttgga agttgctaga  11281

 aacatatgag gaaatgtttc agagattaca gcatatcgga gatcgcttaa ttggctccac  11341

 ttctcagaag gagaaatctg accaaagtca tacagcagaa aaggaacaaa ggccccgatt  11401

 caaacctggg acgtgccctc ccagtccagg gctcattcta ggcatcactc tgcttctcaa  11461

 gaggcgtaaa accggggagt gaaaccaggc agctattttc agagacactc caggtcctat  11521

 ccctctgtga ctctgatctt ccaggccatg accgagcgtg acactgcgtg acactggtag  11581

 atggccacta gagtagcttt ctgagagtca taagacgcca ttgcacccac atgcagagga  11641

 gctgctcagc agtaattctg gttctcctcc ttctgggcag gtggtaggat gccgcagggc  11701

 cagtgggctg tgtgcagata tgacaaatgt ctcctgtggc tcagagcagc aagagcctcc  11761

 agtgtgtcct tccccagcca taacaactgg tgacgtccca cagggtggag cctccatctg  11821

 ccaggggctc tgagaaccct gagccaccgg gaaagccaca gtagacatgt agcatgagaa  11881

 ataaaacttc gtcatgctag ccactaaaat gatgaggttg tacgttactg caacataact  11941

 tagcccatcc caacccagcc accatgggaa ccagcttcta tctgatgtcc cagcctgtgc  12001

 ccatgttaca ggcaaagctg taggcaacct ggtaacatgg cattttctgg acacagagtt  12061

 atttctttag ggccacaagc caatggtttc gtgtgctggt tctagtttcc atgaatgtgt  12121

 tacgatcaga cttttaagtt gtgaggaaaa cccaccatgt tactgatgta gctcttcaga  12181

 aagagcaggt gttactgcaa acaggagact ggcactgccc aaagcccttc tcctagcaat  12241

 cacaatagct gtatcattct gttgcggtgt atgtgttgga gggggaaggg ggaattgatt  12301

 ttgaggcaag accttgggtt cagcgttctt cgtttgcttt tttagagaaa gggcctcact  12361

 ctgttgccca ggctggagtg cagtggcaca atcatagttc actgtaacct cgaactcctg  12421

 ggctcaagta ctcctcccac ctcagccttc tgagtagctg tgaccacagg tgcaaaccac  12481

 catgcctagg atcaggattt ttggcagaac aacactggat gtcaataaat agttcaactc  12541

 aaatggcaat cactgacacc tcctggctgc gggtcactgg agggtgacag tgatgaagga  12601

 cacagccctt tcactgcaat agctcatagt ctagtcagag agagatatac aagaaaaatg  12661

 aactataatg aaggcagaat gaacttaacc tccactaata gctgtgtgac catcttgttg  12721

 tccgggtggt cagttttatg aagccatctg agagaaggct gcacgagaca gtggtgtgtg  12781

 aactgagcct tgaaggatga gtagaaaaga aaggcactcc agcctgaaga aactgcccaa  12841

 gaagagggat gggactggag cacacaggct ttgtccaaaa gacagggagt ggtctgatga  12901

 ggctgcagca ggtgtgcatg agggatgcgg tggaggcaag gcaggaggac gggccagagc  12961

 ctgcacacac aaaagccctc aaatgcctcc gccaggccca cttggtctta ctgttagagg  13021

 tgtgagtgat aaagaaaaat gcagtcaggt ggtttcccac ccttggcctg cttgaaaccc  13081

 ccacgcctgt gtccagtgtc agaatttgag atggacatag ttctgtctgc agcaacaccc  13141

 ccatcagaaa caaagctctt atagttctgc tttccagatt tcaggtttta ctttgtcttt  13201

 acatcccaga ctcagagaga atctcagaga tctaaagcct ggagagagga gggggaggtg  13261

 tccaaagtca ccgagtgagt gaatgaatga ctgcaaactc catgagggca ggagccaggt  13321

 ctgtctctgc tgtattccca gcacctggcc cagggcctaa cacatagtag gtgctcaata  13381

 actatttgtt gaataagtga atgaatgagg cttcacactt ggggaattct ttactttttg  13441

 ccaaacatca ccaagaaaat ccctaactgt agatgttcac atggatgata gttaaaggtc  13501

 agttactgac caagattacc caagtgcccc tatatgttcc tgaaactgtc ctttaagaat  13561

 caccctgatt cagggtagag gaaggaaatc ctgcacaggc tctggagaaa gctggtgtca  13621

 tggaggacac tggagccctt gtccaggagg tggctagtat agatggagca ggaacctgta  13681

 gatagaggag gcacctgtag ctgatgatgg atgccatcct ccatccagcc tcagtaacag  13741

 gtcattgcac cccccggggc agcaccttca ggtgtatgtt tcctctgagc tacatagcat  13801

 cccagtcttc aaggaggaag ctgagtctga gagaggtcaa gtgtcttggt cagtgtcaca  13861

 cagctagtct gaactacagc caggaggcaa agctgggttt tggagtcgtg cattcgctat  13921

 ctgctgggtg cctgctattg gcagcacttg ctgcatgagg tgctggtagg aaggaggcag  13981

 agtcctgctc ttaaggtgta gtagagaaga caggtgcacc acagcgcaca atgacacaga  14041

 gggatggcca agggcagtgg gagcacaaga aggcagcagg taacagcaag gggaaggaga  14101

 gggaggaaaa gagatggagc agtgctgggc tctggagaat gggcagaaca ccccccactg  14161

 gggatgggcg ggaggacacg cctccatctc ggacaaaggt gcggagctgg gaaaagagat  14221

 ggtttcttca ggaaagggtg agccctgcaa ctcgacaaat cgtggataca acgaaacagg  14281

 aggaataaga gaaagaagaa atctagcccg gaaggacaga cagggctcca ctgctgtcac  14341

 aaagcactgt cctcacaacc aacccaggag cgaagggcag gaggggagag gtggattata  14401

 tcttctgagt gataaaagtt cacactcagc tcctattttt ccttcagacc aggggccacc  14461

 tggccataag acatttttcc agttctaaca agactactgt tctctggaca cacctgggct  14521

 tcctcctagg aatacctgac gctggccttt cccgaggaga agtgagagca gctctgcatg  14581

 gcgatggagg tcacctggga gagaccacag cctcgcccac cgctcccttt gcaaagctgg  14641

 tcacaactga ccgcacctcc accagattcg tgcctggctt ccctcctcgt gtgacatcat  14701

 tgtcagtatc atttctccta caaagcaata tggaggccag aaagtaagtt gcttggcttt  14761

 catgaccaca gttcagtcct gtgaccagta actctattga gacatgtacg ttcttatgtg  14821

 tccttttaaa caaaataatg aatggtccat gattccttaa ggagagatga ccagaaatca  14881

 agcttacaca tcctatgggg ctgaaatatt tgatcttcat ggcccaagga acactaggtg  14941

 agcatcatcc attacccacc tgccttccgg agctcatctc acctgactca gggagtgggg  15001

 cagcgcctgt gacaggtgtg gaatcctttt gtccacttac tttccttact gctatagccc  15061

 cagcacctga tacctagcac agaataggta cttaataaat acttagtgga tgaataaatc  15121

 tgaaatacta tggccataat ttggtcacat gaaaccgtaa tgtagaaaag atgcttcctg  15181

 ttaatgacca aaaacacttt ggattccaaa cgatcatttt aaacatgaat ctttctctgc  15241

 tgtctcctct gaccccatcc tggggagagc agagaggagc ctaggggact agaatgtgcc  15301

 ccatcctccc ctcagtgacg tccacagaac tgcagcgctg agaaggccag attgcagatc  15361

 tgaagtccaa ctccctcatt atacagatgg tgaaactaaa ttccagagag ggaggctgac  15421

 ctgctgcagc tcagacatca ggtcactggg ctcccaggcc agttggagct ttttccaaaa  15481

 agctgggtgg tccagatgga aaaggagaga gaatgagatg aagtgggcaa accagacagc  15541

 tgtgacggaa tacgtcctga tggggctaca cgagcactgt aacctggagg tggtcctgtt  15601

 tgtgttctgc ctgggcatct actccgtgaa tgtgttgggg aacgccctcc tcatagggct  15661

 gaacgtgctg caccctcgcc tgcacaaccc catgtacttc tcagcaacct ctccctcatg  15721

 gacatctgcg gcacctcctc ctttgtgcct ctcatgctag acaatttcct ggaaacccag  15781

 aggaccattt ccttccctgg ctgtgccctg cagatgtacc tgaccctggc gctgggatca  15841

 acggagtgcc tgctgctggc tgtgatggca tatgaccgtt atgtggctat ctgccagccg  15901

 cttaggtacc cagagctcat gagtgggcag acctgcatgc agatggcagc gctgagctgg  15961

 gggacaggct ttgccaactc actgctacag tccatccttg tctggcacct ccccttctgt  16021

 ggccacgtca tcaactactt ctatgagatc ttggcagtgc taaaactggc ctgtggggac  16081

 atctccctca atgcgctggc attaatggtg gccacagccg tcctgacact ggcccccctc  16141

 ttgctcatct gcctgtctta ccttttcatc ctgtctgcca tccttagggt accctctgct  16201

 gcaggccggt gcaaagcctt ctccacctgc tcagcccacc gcacagtggt ggtggttttt  16261

 tatgggacaa tctccttcat gtacttcaaa cccaaggcca aggatcccaa cgtggataag  16321

 actgtcgcat tgttctacgg ggttgtgacg ccctcgctga accccatcat ttacagcctg  16381

 aggaatgcag aggtgaaagc tgccgtccta actctgctga gaggaggttt gctctccagg  16441

 aaagcatccc actgctactg ctgccctctg cccctgtcag ctggcatagg ctaggttgtg  16501

 ctgtggtcat gacctcaaac cttgagaggc ttaaagccat taaggtttgt ttcttgctcc  16561

 tgatgcaggt ccaccag                                                 16578




      <210> 263
      <211> 1411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (179)..(859)

      <400> 263
 tgcccaggcc ctcacgcctc ctccgatacc caatggctct gccccggaag ggcctgcatc     60

 cccaggctcc caagtccaca ggacgctcct tgggttaacg tgtaaccatg agccctcccc    120

 tccaccccct gaagccactc gctcccagat taggtcgctc tggggctatc aggccagc      178                                                                 
 atg gac gct ggc aaa gcg ggg cag acc ctg aag act cac tgc tca gcc      226
 Met Asp Ala Gly Lys Ala Gly Gln Thr Leu Lys Thr His Cys Ser Ala
   1               5                  10                  15

 cag cgc cca gat gtc tgc agg tgg ctg agc ccc ttc atc ctc tcc tgc      274
 Gln Arg Pro Asp Val Cys Arg Trp Leu Ser Pro Phe Ile Leu Ser Cys
              20                  25                  30

 tgc gtg tac ttc tgc ctc tgg att ccc gag gac cag ctg tcc tgg ttc      322
 Cys Val Tyr Phe Cys Leu Trp Ile Pro Glu Asp Gln Leu Ser Trp Phe
          35                  40                  45

 gct gcc ctg gtc aag tgc ctg ccc gtc ctc tgc ctg gct ggg ttc ctg      370
 Ala Ala Leu Val Lys Cys Leu Pro Val Leu Cys Leu Ala Gly Phe Leu
      50                  55                  60

 tgg gtc atg tcc cca agc ggg ggc tac acc cag ctc ctc cag gga gcc      418
 Trp Val Met Ser Pro Ser Gly Gly Tyr Thr Gln Leu Leu Gln Gly Ala
  65                  70                  75                  80

 ctt gtg tgc tcg gct gtg ggg gac gct tgc ctc atc tgg ccg gca gcc      466
 Leu Val Cys Ser Ala Val Gly Asp Ala Cys Leu Ile Trp Pro Ala Ala
                  85                  90                  95

 ttc gtc cct ggc atg gcc gcc ttt gcc acc gcc cac ctc ctc tac gtc      514
 Phe Val Pro Gly Met Ala Ala Phe Ala Thr Ala His Leu Leu Tyr Val
             100                 105                 110

 tgg gcc ttc ggc ttc tct ccc ctg cag ccc ggc ctg ctg ctg ctc atc      562
 Trp Ala Phe Gly Phe Ser Pro Leu Gln Pro Gly Leu Leu Leu Leu Ile
         115                 120                 125

 atc ctg gcc cct ggc ccc tac ctc agc ctt gtg ctc cag cac ctc gag      610
 Ile Leu Ala Pro Gly Pro Tyr Leu Ser Leu Val Leu Gln His Leu Glu
     130                 135                 140

 ccg gat atg gtc ctg ccg gtg gca gcc tat ggg ctg atc ctg atg gcc      658
 Pro Asp Met Val Leu Pro Val Ala Ala Tyr Gly Leu Ile Leu Met Ala
 145                 150                 155                 160

 atg ctg tgg cgc ggc ctg gcc cag ggc ggg agt gcc ggc tgg ggc gcg      706
 Met Leu Trp Arg Gly Leu Ala Gln Gly Gly Ser Ala Gly Trp Gly Ala
                 165                 170                 175

 ctg ctc ttc acg ctc tct gat ggc gtg ctg gcc tgg gac acc ttc gcc      754
 Leu Leu Phe Thr Leu Ser Asp Gly Val Leu Ala Trp Asp Thr Phe Ala
             180                 185                 190

 cag ccc ctg ccc cat gcc cgc ctg gtg atc atg acc acc tac tat gct      802
 Gln Pro Leu Pro His Ala Arg Leu Val Ile Met Thr Thr Tyr Tyr Ala
         195                 200                 205

 gcc cag ctc ctc atc aca ctg tca gcc ctc agg agc ccg gtg ccc aag      850
 Ala Gln Leu Leu Ile Thr Leu Ser Ala Leu Arg Ser Pro Val Pro Lys
     210                 215                 220

 act gac tga ctaggga gcttgaaggg ccggtgttca ggccctctcc tcctgcaagg      906
 Thr Asp 
 225

 acctgggcct cccagcccag cccagcctga gaaataccct cagcagcgaa gcttcctgac    966

 gcctgtctgc aggcgccgct gccgccgtcg cttctggctg aagacgtttg aggacgattt   1026

 gcggaattcc aagtccacta ctgggttcca gctgccttcc cccggttctg actccagatc   1086

 cctggctcct cagccaggcc cacatggagc cctcccagcc accagcctgc ctccatgttc   1146

 actgtcggcc ccacagcctg cccgccccct gctgctgctc tgaatccgtt ttccctgtgg   1206

 gtgtggaacc gtagatgttg ctgttaccgt aggagaggcc tcggggaggg tcatcattgt   1266

 gataaaccat cgcggttaat gccagcagaa ggttttttgt cgctccccat ggaccaggcc   1326

 tggtgcccag tgggaccctc catggccctt tggtgggggg attcgggggg ataaagttag   1386

 gattgtgcag aactgaaaaa aaaaa                                         1411




      <210> 264
      <211> 625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(578)

      <400> 264
 ggcacgaggc tcaagatgag gaggtgcgcg gggccggggc ggagcagtcg cgttccccgc     60

 gtgtgagccc ccacccatcc ctggcgccag cgcttccccg accactcggg ttcggctatg    120

 cgggagccgt gaggaggagg cttgcagtcg tggacctgag acctcgggag gtcatgctgt    180

 cttgctttta agtggcttgg ggaaagtgaa gaaaccccaa a    atg gag gac ttt     233
                                                  Met Glu Asp Phe
                                                    1

 gct acc agg acc tac ggc acc agt ggc ctg gac aac aga cct ctg ttt      281
 Ala Thr Arg Thr Tyr Gly Thr Ser Gly Leu Asp Asn Arg Pro Leu Phe
   5                  10                  15                  20

 ggg gag acg tcc gcc aag gat cga atc atc aat tta gtt gtt ggc agc      329
 Gly Glu Thr Ser Ala Lys Asp Arg Ile Ile Asn Leu Val Val Gly Ser
                  25                  30                  35

 tta aca tcc tta ttg att cta gta acg ctg ata agt gct ttt gtt ttc      377
 Leu Thr Ser Leu Leu Ile Leu Val Thr Leu Ile Ser Ala Phe Val Phe
              40                  45                  50

 cct caa cta cct cca aaa ccg ttg aat ata ttc ttt gct gtc tgc atc      425
 Pro Gln Leu Pro Pro Lys Pro Leu Asn Ile Phe Phe Ala Val Cys Ile
          55                  60                  65

 tct ttg agt agt att act gcc tgc ata ctt atc tac tgg tat cga caa      473
 Ser Leu Ser Ser Ile Thr Ala Cys Ile Leu Ile Tyr Trp Tyr Arg Gln
      70                  75                  80

 gga gac tta gaa ccg aaa ttt aga aag cta att tac tat atc ata ttt      521
 Gly Asp Leu Glu Pro Lys Phe Arg Lys Leu Ile Tyr Tyr Ile Ile Phe
  85                  90                  95                 100

 tct atc atc atg ttg tgt ata tgt gca aac ctg tac ttc cat gat gtg      569
 Ser Ile Ile Met Leu Cys Ile Cys Ala Asn Leu Tyr Phe His Asp Val
                 105                 110                 115

 gga agg tga ggctgcc aaggagaagt acttaccagg actcttcaaa atgatacatt      625
 Gly Arg 






      <210> 265
      <211> 1078
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (558)..(1028)

      <400> 265
 cctgaccaca tgtggtccac ccaccttggc ctcaattatg tgcattttgg tatatttact     60

 tgtatttcaa catcttgtga gtttgaaaaa cctgaaaggc cagaatgctt ccttttattt    120

 ctcaccattt gggcagcacc taagtggttt tgtaaaatgc agcatctggt gctgtgggtc    180

 tctctcaggc cttgagggac acttccttcc tccccactcg cctcctctcc actagacttt    240

 ggttcctaga gggcgtgggg ccgggtctga ggttcttgcc tgccttccct cccattggtc    300

 tttggttgct catccctcta actgcacccc ttcttggtcc ttcctccaca gacttcagat    360

 aatagataag tcattagcaa accagaccga atctttaggg tgaagagctc cccaaagcca    420

 tctggtgagg tcattgtggg gaccagggac tgattatttg tcacctggat cacaaagatg    480

 ggactgtctg ctcaggctgg tggtgacagg atcctgaccc gtggtcctct cccgctccct    540

 ctgctccacc aggacac   atg tat agg aca ctg tgc tgt gtg cag tgg aga     590
                      Met Tyr Arg Thr Leu Cys Cys Val Gln Trp Arg
                        1               5                  10

 aat ctc cct ggg cca ggg gaa agt tca gac agt gcc tct aga ttg tgt      638
 Asn Leu Pro Gly Pro Gly Glu Ser Ser Asp Ser Ala Ser Arg Leu Cys
              15                  20                  25

 ttt gcc tcc tcc aat gta gag ttg aca tct gga ccc cag agc cca gca      686
 Phe Ala Ser Ser Asn Val Glu Leu Thr Ser Gly Pro Gln Ser Pro Ala
          30                  35                  40

 ggg ctt tct gtc aga cat gct agg gtg gta gaa atg ggc cct cca ggt      734
 Gly Leu Ser Val Arg His Ala Arg Val Val Glu Met Gly Pro Pro Gly
      45                  50                  55

 ccc cct gca gtg cac tgg gca gag acc tcc gga aag ccg gca gcg gga      782
 Pro Pro Ala Val His Trp Ala Glu Thr Ser Gly Lys Pro Ala Ala Gly
  60                  65                  70                  75

 gcg ctt cct ggg cag ctt ccc cca gca cag tgt tcc caa acc agt cca      830
 Ala Leu Pro Gly Gln Leu Pro Pro Ala Gln Cys Ser Gln Thr Ser Pro
                  80                  85                  90

 tcc gga aaa cag tct gta cag caa atg ctg tgt gag atc tta ggc ttt      878
 Ser Gly Lys Gln Ser Val Gln Gln Met Leu Cys Glu Ile Leu Gly Phe
              95                 100                 105

 tca ctt ttt ttg ttt tgt ttt gtt ttt gaa aga aag aaa aaa ata caa      926
 Ser Leu Phe Leu Phe Cys Phe Val Phe Glu Arg Lys Lys Lys Ile Gln
         110                 115                 120

 tta aca agc ctc ttt tgt aaa tgg gtt tcc ttt cta tgt ata aaa tcg      974
 Leu Thr Ser Leu Phe Cys Lys Trp Val Ser Phe Leu Cys Ile Lys Ser
     125                 130                 135

 tgg tgg tcc ctt gtt ttt aca tgt tca tgc tgt gta att ttg aga tgt     1022
 Trp Trp Ser Leu Val Phe Thr Cys Ser Cys Cys Val Ile Leu Arg Cys
 140                 145                 150                 155

 tac tga gatatgttct gaacataatg tgcatttttt tctgtacaga tgaaatggga      1078
 Tyr 






      <210> 266
      <211> 2637
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (304)..(2637)

      <400> 266
 accatctact ccacagtcag cacatccaca actgccatca cctcacattt tactacctca     60

 gagactgcgg tgactcccac acctgtaacc ccatcttctc tgagtacaga catcccgacc    120

 acaagcctac gaactctcac cccttcgtct gtgggcacca gcacttcatt gactacaacc    180

 acagactttc cctctatacc cactgatatc agtaccttac caactcgaac acacatcatt    240

 tcatcttctc cctccatcca aagtacagaa acctcatccc ttgtgggcac cacctctccc    300

 acc  atg tcc act gtg aga atg acc ctc aga att act gag aac acc cca     348
      Met Ser Thr Val Arg Met Thr Leu Arg Ile Thr Glu Asn Thr Pro
        1               5                  10                  15

 atc agt tcc ttt agc aca agt att gtt gtt ata cct gaa acc cca aca      396
 Ile Ser Ser Phe Ser Thr Ser Ile Val Val Ile Pro Glu Thr Pro Thr
                  20                  25                  30

 aca cag gcc cct cct gta ctg atg tct gcc act ggg acc caa aca tcc      444
 Thr Gln Ala Pro Pro Val Leu Met Ser Ala Thr Gly Thr Gln Thr Ser
              35                  40                  45

 cct gta cct act act gtc acc ttt gga agt atg gat tcc tct acg tcc      492
 Pro Val Pro Thr Thr Val Thr Phe Gly Ser Met Asp Ser Ser Thr Ser
          50                  55                  60

 act ctt cat act ctt act cca tca aca gcc ttg agc aag atc atg tca      540
 Thr Leu His Thr Leu Thr Pro Ser Thr Ala Leu Ser Lys Ile Met Ser
      65                  70                  75

 aca tca cag ttt cct att cct agc aca cat tcc tcc acc ctt caa aca      588
 Thr Ser Gln Phe Pro Ile Pro Ser Thr His Ser Ser Thr Leu Gln Thr
  80                  85                  90                  95

 act cct tca atc ccc tct ttg caa act tca ctc aca tct aca agt gag      636
 Thr Pro Ser Ile Pro Ser Leu Gln Thr Ser Leu Thr Ser Thr Ser Glu
                 100                 105                 110

 ttc act aca gaa tct ttc act agg gga agt acg tct aca aat gca atc      684
 Phe Thr Thr Glu Ser Phe Thr Arg Gly Ser Thr Ser Thr Asn Ala Ile
             115                 120                 125

 ttg act tct ttt agt acc atc atc tgg tcc tca aca ccc act att atc      732
 Leu Thr Ser Phe Ser Thr Ile Ile Trp Ser Ser Thr Pro Thr Ile Ile
         130                 135                 140

 atg tcc tct tct cca tct tct gcc agc ata act cca gtg ttc gct act      780
 Met Ser Ser Ser Pro Ser Ser Ala Ser Ile Thr Pro Val Phe Ala Thr
     145                 150                 155

 acc att cat tct gtt cct tcg tca cca tac att ttc agt aca gaa aat      828
 Thr Ile His Ser Val Pro Ser Ser Pro Tyr Ile Phe Ser Thr Glu Asn
 160                 165                 170                 175

 gtg ggc tcc gct tct atc aca gcc ttt cct agt ctc tct tcc tct tca      876
 Val Gly Ser Ala Ser Ile Thr Ala Phe Pro Ser Leu Ser Ser Ser Ser
                 180                 185                 190

 act acc agc act tct cca acc agc tcc tct ctg acc aca gct ctc act      924
 Thr Thr Ser Thr Ser Pro Thr Ser Ser Ser Leu Thr Thr Ala Leu Thr
             195                 200                 205

 gaa ata acc ccc ttt tct tat att tcc ctt ccc tcc acc aca ccc tgt      972
 Glu Ile Thr Pro Phe Ser Tyr Ile Ser Leu Pro Ser Thr Thr Pro Cys
         210                 215                 220

 cca gga act ata aca att acc ata gtc cct gcc tcc ccc act gat cca     1020
 Pro Gly Thr Ile Thr Ile Thr Ile Val Pro Ala Ser Pro Thr Asp Pro
     225                 230                 235

 tgt gtt gaa atg gat ccc agc act gaa gct act tct cct ccc acc act     1068
 Cys Val Glu Met Asp Pro Ser Thr Glu Ala Thr Ser Pro Pro Thr Thr
 240                 245                 250                 255

 cca tta aca gtc ttt ccc ttt act act gaa atg gtc acc tgt cct agc     1116
 Pro Leu Thr Val Phe Pro Phe Thr Thr Glu Met Val Thr Cys Pro Ser
                 260                 265                 270

 tcc atc agt atg caa act act ctt gct aca cat atg gac act tct tcc     1164
 Ser Ile Ser Met Gln Thr Thr Leu Ala Thr His Met Asp Thr Ser Ser
             275                 280                 285

 atg acg cca gaa agt gag tcc agc atc ata cct aat gct tcc agt tcc     1212
 Met Thr Pro Glu Ser Glu Ser Ser Ile Ile Pro Asn Ala Ser Ser Ser
         290                 295                 300

 act ggc act ggg act gta ccc aca aac aca gtt ttc aca agt act cga     1260
 Thr Gly Thr Gly Thr Val Pro Thr Asn Thr Val Phe Thr Ser Thr Arg
     305                 310                 315

 ctg ccc acc agt gag acc tgg ctg agc aac aac tct gtg atc ccc aca     1308
 Leu Pro Thr Ser Glu Thr Trp Leu Ser Asn Asn Ser Val Ile Pro Thr
 320                 325                 330                 335

 cct ctt cct ggc gtc tct acc atc ccg ctc acc atg aaa cca agc agt     1356
 Pro Leu Pro Gly Val Ser Thr Ile Pro Leu Thr Met Lys Pro Ser Ser
                 340                 345                 350

 agc ctc ccg acc atc ctg agg act tca agc aag tca aca cac cca tcc     1404
 Ser Leu Pro Thr Ile Leu Arg Thr Ser Ser Lys Ser Thr His Pro Ser
             355                 360                 365

 cca ccc acc gcc agg act tca gag aca tca gtg gcc act acc cag act     1452
 Pro Pro Thr Ala Arg Thr Ser Glu Thr Ser Val Ala Thr Thr Gln Thr
         370                 375                 380

 cct acc acc ctt aca acg cgc agg aca act ccc atc act tct tgg atg     1500
 Pro Thr Thr Leu Thr Thr Arg Arg Thr Thr Pro Ile Thr Ser Trp Met
     385                 390                 395

 acc aca cag tcc acg ttg acc acc act gca ggc acc tgt gac aat ggt     1548
 Thr Thr Gln Ser Thr Leu Thr Thr Thr Ala Gly Thr Cys Asp Asn Gly
 400                 405                 410                 415

 ggc acc tgg gaa cag ggc cag tgt gct tgc ctt ccg ggg ttt tct ggg     1596
 Gly Thr Trp Glu Gln Gly Gln Cys Ala Cys Leu Pro Gly Phe Ser Gly
                 420                 425                 430

 gac cgc tgt cag ctc cag acc aga tgc cag aat ggg ggt cag tgg gat     1644
 Asp Arg Cys Gln Leu Gln Thr Arg Cys Gln Asn Gly Gly Gln Trp Asp
             435                 440                 445

 ggc ctc aaa tgc cag tgc ccc agc acc ttc tat ggt tcc agt tgt gag     1692
 Gly Leu Lys Cys Gln Cys Pro Ser Thr Phe Tyr Gly Ser Ser Cys Glu
         450                 455                 460

 ttt gct gtg gaa cag gtg gat cta gat gta gtg gag acc gag gtg ggc     1740
 Phe Ala Val Glu Gln Val Asp Leu Asp Val Val Glu Thr Glu Val Gly
     465                 470                 475

 atg gaa gtg tct gtg gat cag cag ttc tcg ccg gac ctc aat gac aac     1788
 Met Glu Val Ser Val Asp Gln Gln Phe Ser Pro Asp Leu Asn Asp Asn
 480                 485                 490                 495

 act tcc cag gcc tac agg gat ttc aac aag acc ttc tgg aat cag atg     1836
 Thr Ser Gln Ala Tyr Arg Asp Phe Asn Lys Thr Phe Trp Asn Gln Met
                 500                 505                 510

 cag aag att ttt gca gac atg cag ggc ttc acc ttc aag ggt gtg gag     1884
 Gln Lys Ile Phe Ala Asp Met Gln Gly Phe Thr Phe Lys Gly Val Glu
             515                 520                 525

 atc ctg tcc ctg agg aat ggc agc atc gtg gtg gac tac ctg gtc ctg     1932
 Ile Leu Ser Leu Arg Asn Gly Ser Ile Val Val Asp Tyr Leu Val Leu
         530                 535                 540

 ctg gag atg ccc ttc agc ccc cag ctg gag agc gag tat gag cag gtg     1980
 Leu Glu Met Pro Phe Ser Pro Gln Leu Glu Ser Glu Tyr Glu Gln Val
     545                 550                 555

 aag acc acg ctg aag gag ggg ctg cag aac gcc agc cag gat gtg aac     2028
 Lys Thr Thr Leu Lys Glu Gly Leu Gln Asn Ala Ser Gln Asp Val Asn
 560                 565                 570                 575

 agc tgc cag gac tcc cag acc ctg tgt ttt aag cct gac tcc atc aag     2076
 Ser Cys Gln Asp Ser Gln Thr Leu Cys Phe Lys Pro Asp Ser Ile Lys
                 580                 585                 590

 gtg aac aac aac agc aag aca gag ctg acc ccg gca gcc atc tgc cgc     2124
 Val Asn Asn Asn Ser Lys Thr Glu Leu Thr Pro Ala Ala Ile Cys Arg
             595                 600                 605

 cgc gcc gct ccc acg ggc tat gaa gag ttc tac ttc ccc ttg gtg gag     2172
 Arg Ala Ala Pro Thr Gly Tyr Glu Glu Phe Tyr Phe Pro Leu Val Glu
         610                 615                 620

 gcc acc cgg ctc cgc tgt gtc acc aaa tgc acg tcg ggg gtg gac aac     2220
 Ala Thr Arg Leu Arg Cys Val Thr Lys Cys Thr Ser Gly Val Asp Asn
     625                 630                 635

 gcc atc gac tgt cac cag ggc cag tgc gtt ctg gag acg agc ggt ccc     2268
 Ala Ile Asp Cys His Gln Gly Gln Cys Val Leu Glu Thr Ser Gly Pro
 640                 645                 650                 655

 acg tgt cgc tgc tac tcc acc gac acg cac tgg ttc tct ggc ccg cgc     2316
 Thr Cys Arg Cys Tyr Ser Thr Asp Thr His Trp Phe Ser Gly Pro Arg
                 660                 665                 670

 tgc gag gtg gcc gtc cac tgg agg gcg ctg gtc ggg ggc ctg acg gcc     2364
 Cys Glu Val Ala Val His Trp Arg Ala Leu Val Gly Gly Leu Thr Ala
             675                 680                 685

 ggc gcc gcg ctg ctg gtg ctg ctg ctg ctg gcg ctg ggc gtc cgg gcg     2412
 Gly Ala Ala Leu Leu Val Leu Leu Leu Leu Ala Leu Gly Val Arg Ala
         690                 695                 700

 gtg cgc tcc gga tgg tgg ggc ggc cag cgc cga ggc cgg tcc tgg gac     2460
 Val Arg Ser Gly Trp Trp Gly Gly Gln Arg Arg Gly Arg Ser Trp Asp
     705                 710                 715

 cag gac agg aaa tgg ttc gag acc tgg gat gag gaa gtc gtg ggc act     2508
 Gln Asp Arg Lys Trp Phe Glu Thr Trp Asp Glu Glu Val Val Gly Thr
 720                 725                 730                 735

 ttt tca aac tgg ggt ttc gag gac gac gga aca gac aag gat aca aat     2556
 Phe Ser Asn Trp Gly Phe Glu Asp Asp Gly Thr Asp Lys Asp Thr Asn
                 740                 745                 750

 ttc tat gtg gcc ttg gag aac gtg gac acc act atg aag gtg cac atc     2604
 Phe Tyr Val Ala Leu Glu Asn Val Asp Thr Thr Met Lys Val His Ile
             755                 760                 765

 aag aga ccc gag atg acc tcg tcc tca gtg tga                         2637
 Lys Arg Pro Glu Met Thr Ser Ser Ser Val 
         770                 775





      <210> 267
      <211> 1740
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1416)

      <400> 267
  atg gaa ttt gtt acg gcc ctg gct gac ctc cga gca gag gct agc tgt      48
  Met Glu Phe Val Thr Ala Leu Ala Asp Leu Arg Ala Glu Ala Ser Cys
    1               5                  10                  15

 ccc atc tgt ctg gac tac ttg aaa gac cca gtg acc atc agc tgt ggg       96
 Pro Ile Cys Leu Asp Tyr Leu Lys Asp Pro Val Thr Ile Ser Cys Gly
              20                  25                  30

 cat aac ttc tgt ctc tcc tgc atc att atg tcc tgg aag gat cta cat      144
 His Asn Phe Cys Leu Ser Cys Ile Ile Met Ser Trp Lys Asp Leu His
          35                  40                  45

 gat agt ttc ccc tgc ccc ttt tgc cac ttt tgc tgt cca gaa agg aaa      192
 Asp Ser Phe Pro Cys Pro Phe Cys His Phe Cys Cys Pro Glu Arg Lys
      50                  55                  60

 ttt ata agc aat ccc cag ctg ggt agt ttg act gaa att gct aag caa      240
 Phe Ile Ser Asn Pro Gln Leu Gly Ser Leu Thr Glu Ile Ala Lys Gln
  65                  70                  75                  80

 ctc cag ata aga agc aag aag agg aag agg cag gaa gag aag cat gtg      288
 Leu Gln Ile Arg Ser Lys Lys Arg Lys Arg Gln Glu Glu Lys His Val
                  85                  90                  95

 tgt aag aag cat aat cag gtt ttg act ttc ttc tgt cag aaa gac cta      336
 Cys Lys Lys His Asn Gln Val Leu Thr Phe Phe Cys Gln Lys Asp Leu
             100                 105                 110

 gag ctt tta tgt cca agg tgc agt ttg tcc act gat cac cag cat cac      384
 Glu Leu Leu Cys Pro Arg Cys Ser Leu Ser Thr Asp His Gln His His
         115                 120                 125

 tgt gtt tgg ccc ata aag aag gct gcc tcc tat cat agg aaa aaa ctg      432
 Cys Val Trp Pro Ile Lys Lys Ala Ala Ser Tyr His Arg Lys Lys Leu
     130                 135                 140

 gag gaa tac aat gca ccg tgg aag gag aga gtg gaa cta att gaa aaa      480
 Glu Glu Tyr Asn Ala Pro Trp Lys Glu Arg Val Glu Leu Ile Glu Lys
 145                 150                 155                 160

 gtc ata act atg caa acc agg aaa tca ctg gaa ctg aag aaa aag gta      528
 Val Ile Thr Met Gln Thr Arg Lys Ser Leu Glu Leu Lys Lys Lys Val
                 165                 170                 175

 aaa cat agg gca gaa gaa gtc aag tct gaa ttt gag caa ctt agg tta      576
 Lys His Arg Ala Glu Glu Val Lys Ser Glu Phe Glu Gln Leu Arg Leu
             180                 185                 190

 ttt ctc caa aat gag caa gag act gtt ctt agg caa tta caa gat gaa      624
 Phe Leu Gln Asn Glu Gln Glu Thr Val Leu Arg Gln Leu Gln Asp Glu
         195                 200                 205

 gag atg gat att tta gca caa cta aat gaa agc cta aca aaa ttt tca      672
 Glu Met Asp Ile Leu Ala Gln Leu Asn Glu Ser Leu Thr Lys Phe Ser
     210                 215                 220

 gat tat acc tcc tca tta aaa tat cta cta aag gag ata gag agc ata      720
 Asp Tyr Thr Ser Ser Leu Lys Tyr Leu Leu Lys Glu Ile Glu Ser Ile
 225                 230                 235                 240

 tat gtg aag tca gaa ctg gaa tta ctg gca aat gtt aag gat atc tat      768
 Tyr Val Lys Ser Glu Leu Glu Leu Leu Ala Asn Val Lys Asp Ile Tyr
                 245                 250                 255

 cac aga tat aag aat tta aaa ttc cct gag ctg ttt tta ttc aaa tta      816
 His Arg Tyr Lys Asn Leu Lys Phe Pro Glu Leu Phe Leu Phe Lys Leu
             260                 265                 270

 aaa aaa tat ggt tac cat ctg cct cca caa tat tct ggc cta gac aaa      864
 Lys Lys Tyr Gly Tyr His Leu Pro Pro Gln Tyr Ser Gly Leu Asp Lys
         275                 280                 285

 att atc aag cga ttt caa gta gat gta att cta gat cct gaa aca gca      912
 Ile Ile Lys Arg Phe Gln Val Asp Val Ile Leu Asp Pro Glu Thr Ala
     290                 295                 300

 cat cgt aaa ctt ata gtc tca gaa gat aga aaa act gtg cgc tat gga      960
 His Arg Lys Leu Ile Val Ser Glu Asp Arg Lys Thr Val Arg Tyr Gly
 305                 310                 315                 320

 aat aca aca caa aat gta cct cat aac cca aga aga ttt tat ctc ctc     1008
 Asn Thr Thr Gln Asn Val Pro His Asn Pro Arg Arg Phe Tyr Leu Leu
                 325                 330                 335

 cca gct gtt ctg ggt tct aag gga tat agt tgt ggc agg cag tac tgg     1056
 Pro Ala Val Leu Gly Ser Lys Gly Tyr Ser Cys Gly Arg Gln Tyr Trp
             340                 345                 350

 gaa gta gaa gtg aaa gac aag cct gaa tgg att ctt ggt gtc tgt aat     1104
 Glu Val Glu Val Lys Asp Lys Pro Glu Trp Ile Leu Gly Val Cys Asn
         355                 360                 365

 gac tgt ctt ccc aga agg agg aag agt caa cca att tta gta cag gat     1152
 Asp Cys Leu Pro Arg Arg Arg Lys Ser Gln Pro Ile Leu Val Gln Asp
     370                 375                 380

 gga tta tgg gga att tgg cga tct agt cag aat aat tat att gta ttg     1200
 Gly Leu Trp Gly Ile Trp Arg Ser Ser Gln Asn Asn Tyr Ile Val Leu
 385                 390                 395                 400

 ggc cac aag gaa att att ctg ctg cca caa gta att cct agt aag att     1248
 Gly His Lys Glu Ile Ile Leu Leu Pro Gln Val Ile Pro Ser Lys Ile
                 405                 410                 415

 ggc att ttt tta gac tat gaa atg aat gaa gtt tcc ttt tat aat ttg     1296
 Gly Ile Phe Leu Asp Tyr Glu Met Asn Glu Val Ser Phe Tyr Asn Leu
             420                 425                 430

 aat gat aga tct ctt ctc tat act ttt aat gat aat ttt aca gga gca     1344
 Asn Asp Arg Ser Leu Leu Tyr Thr Phe Asn Asp Asn Phe Thr Gly Ala
         435                 440                 445

 ctt tgg cct tat ttt tat act gga act gac tca aaa cct ctt aaa att     1392
 Leu Trp Pro Tyr Phe Tyr Thr Gly Thr Asp Ser Lys Pro Leu Lys Ile
     450                 455                 460

 tct aca gta aca gat tct gaa tga attattagaa gactcagttt ctttcaccta    1446
 Ser Thr Val Thr Asp Ser Glu 
 465                 470

 gtagacataa ctgagccagt gaatctagtt ttggctattc tgtattttgt ccagtttttc   1506

 ccataagaaa gcaatatttt tttatctcag tttcagcaac ttccaaaaaa tgtgattatg   1566

 ggacctactt tatattaaat tatggggtca gtgacaaggt actttagaaa ttctacagta   1626

 aaatacttga aacatatatt actgaagaaa tgtattatgt aagaaaatct attacttttg   1686

 taattgccaa taaaagccca gtaatttttt ttttgtatta taaaaaaaaa aaaa         1740




      <210> 268
      <211> 2680
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1201)..(1902)

      <400> 268
 tatcagtcat aacttttaat tgaattatcc acaattttgg atttttcact cctccagtta     60

 gaataaataa tcaggagttc actatagtgc taaagagtag atattaagga aaggtttaaa    120

 caagaatgaa caagaagagg tccttcttta gtaagaccct agtcctaaag ctctgtggga    180

 tttacaactt agagccacaa actaaccagc tcatcagaga atgacctgtc agcactgtca    240

 atatcttctc taatgaggta acactatggt attggcacct ggggaattgt ttgcctgtag    300

 tgaactggca cactgtattt tccagttcta ggctctcaca gcagcttatg ccaggattct    360

 gtacaaactt gcagctgggg gccctgtgga ccctgcgcat cacttctgtg gagctgcgga    420

 tgaagttatt gctccacttg cacgatccgt ttgcttctga aacttttctc cagactgtca    480

 tgtcattgca acactctttg tcattacccg aactgtttcc cttggggtca ttataatgta    540

 aacttctgaa tgtcagtaat gtggaagaca tatcatcctt ggacatgctg aggctggtat    600

 ttttaactaa caggatcggg ttcattaata tctcaatggt ctgtttttct tggccacttt    660

 ttgccatgtc atattgcatc tcttcgtctg taaattcttc tttaattatc ttcattgtgc    720

 tttctgatgc ttctgcaaga accaggccca ggctgagcag cagcagagga aaggtctcca    780

 tctcagatgt agtgtaatct cttctgcagg cagggtatct tgtgccttca atgagctgac    840

 agactgtcat tttgaacttt gtctcactct gaaagcagaa aatggccgaa aggttttggc    900

 aagcaacctt cttgggagaa atgcaaatac cattgatttt tcgaggcctc tcatggatga    960

 agacatgctc ctttttacaa gtgtggtcag gttccctgat aactctttgt atgatcatgt   1020

 ggttgcagta ccttgcagga acgggaacgt cattctgagg gtagtccaca tgcaagtgtt   1080

 ctaaagttga catcactgct tcatcattca cctcattttc ccagaacaga agcaccaaga   1140

 aaattatcac cattattatc atcagaggta agagtgactt cgcatctttg gctttgactg   1200
                                                                 
 atg gca aag aaa aga aat aac aat ggt cat gcc aaa aag ggc cac agc     1248
 Met Ala Lys Lys Arg Asn Asn Asn Gly His Ala Lys Lys Gly His Ser
   1               5                  10                  15

 cac gtg cag cct att tgc tac atg aat tat gcc cta tgc cta ccc aaa     1296
 His Val Gln Pro Ile Cys Tyr Met Asn Tyr Ala Leu Cys Leu Pro Lys
              20                  25                  30

 ggc aag act att aag aag ttc atc att caa aac gta gta gag act gca     1344
 Gly Lys Thr Ile Lys Lys Phe Ile Ile Gln Asn Val Val Glu Thr Ala
          35                  40                  45

 cct gtc agg gac att tct gaa gct agt atc ttt gac gcc tat ggg ctt     1392
 Pro Val Arg Asp Ile Ser Glu Ala Ser Ile Phe Asp Ala Tyr Gly Leu
      50                  55                  60

 ccc aag ttg ttc gtg aaa ttc tgt tac gca gtc aaa gcc aaa gat gcg     1440
 Pro Lys Leu Phe Val Lys Phe Cys Tyr Ala Val Lys Ala Lys Asp Ala
  65                  70                  75                  80

 aag tca ctc tta cct ctg atg ata ata atg gtg ata att ttc ttg gtg     1488
 Lys Ser Leu Leu Pro Leu Met Ile Ile Met Val Ile Ile Phe Leu Val
                  85                  90                  95

 ctt ctg ttc tgg gaa aat gag gtg aat gat gaa gca gtg atg tca act     1536
 Leu Leu Phe Trp Glu Asn Glu Val Asn Asp Glu Ala Val Met Ser Thr
             100                 105                 110

 tta gaa cac ttg cat gtg gac tac cct cag aat gac gtt ccc gtt cct     1584
 Leu Glu His Leu His Val Asp Tyr Pro Gln Asn Asp Val Pro Val Pro
         115                 120                 125

 gca agg tac tgc aac cac atg atc ata caa aga gtt atc agg gaa cct     1632
 Ala Arg Tyr Cys Asn His Met Ile Ile Gln Arg Val Ile Arg Glu Pro
     130                 135                 140

 gac cac act tgt aaa aag gag cat gtc ttc atc cat gag agg cct cga     1680
 Asp His Thr Cys Lys Lys Glu His Val Phe Ile His Glu Arg Pro Arg
 145                 150                 155                 160

 aaa atc aat ggt att tgc att tct ccc aag aag gtt gct tgc caa aac     1728
 Lys Ile Asn Gly Ile Cys Ile Ser Pro Lys Lys Val Ala Cys Gln Asn
                 165                 170                 175

 ctt tcg gcc att ttc tgc ttt cag agt gag aca aag ttc aaa atg aca     1776
 Leu Ser Ala Ile Phe Cys Phe Gln Ser Glu Thr Lys Phe Lys Met Thr
             180                 185                 190

 gtc tgt cag ctc att gaa ggc aca aga tac cct gcc tgc agg tac cac     1824
 Val Cys Gln Leu Ile Glu Gly Thr Arg Tyr Pro Ala Cys Arg Tyr His
         195                 200                 205

 tat tcc ccc aca gag ggg ttt gtt ctt gtc act tgt gat gac ttg agg     1872
 Tyr Ser Pro Thr Glu Gly Phe Val Leu Val Thr Cys Asp Asp Leu Arg
     210                 215                 220

 cca gat agt ttc ctt ggc tat gtt aaa taa c tcaagatcag ctcccgagtc     1923
 Pro Asp Ser Phe Leu Gly Tyr Val Lys 
 225                 230

 tgagatctct tctctcaatg gcattggagc tggctgtgcc tgaggcagac ctggaccgtg   1983

 gacatggggc aatgccttga gcggaagggg aagccactga agagattaca ctacatctga   2043

 gatggagacc tttcctctgc tgctgctcag cctgggcctg gttcttgcag aagcatcaga   2103

 aagcacaatg aagataatta aagaagaatt tacagacgaa gagatgcaat atgacatggc   2163

 aaaaagtggc caagaaaaac agaccattga gatattaatg aacccgatcc tgttagttaa   2223

 aaataccagc ctcagcatgt ccaaggatga tatgtcttcc acattactga cattcagaag   2283

 tttacattat aatgacccca agggaaacag ttcgggtaat gacaaagagt gttgcaatga   2343

 catgacagtc tggagaaaag tttcagaagc aaacggatcg tgcaagtgga gcaataactt   2403

 catccgcagc tccacagaag tgatgcgcag ggtccacagg gcccccagct gcaagtttgt   2463

 acagaatcct ggcataagct gctgtgagag cctagaactg gaaaatacag tgtgccagtt   2523

 cactacaggc aaacaattcc ccaggtttca aagcatggtg aacttattcg aaatcatata   2583

 cagcaatcat tacgaagatg tttaatgaag aatgcccagg aggcaaatac tattattctt   2643

 ccccctttag cgatgaagaa acagaagcac aaagact                            2680




      <210> 269
      <211> 4499
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (344)..(3757)

      <400> 269
 gcaggaacga gccttccaga tgccaaagag ctattcccag ctgattgctg agtggccagt     60

 ggccgtgctg atgctgtgtc tggctgtcat cttcctctgc accctggctg gactgttggg    120

 ggcccggctg cccgacttct ccaagccttt gctgggcttt gagccacggg acacagacat    180

 tgggagcaag ttagtggtct ggagagcact acaagccctc acaggcccca ggaagctgct    240

 tttcctttcc ccagaccttg agctgaacag ctcgagctcc cacaacactc tgaggcctgc    300

 acccagaggc agtgcccagg agagcgctgt ccggcctcgg aga  atg gtg gag ccc     355
                                                  Met Val Glu Pro
                                                    1

 ctg gag gac aga agg caa gag aac ttc ttc tgt ggc ccc cct gag aag      403
 Leu Glu Asp Arg Arg Gln Glu Asn Phe Phe Cys Gly Pro Pro Glu Lys
   5                  10                  15                  20

 agc tat gca aag ctg gtg ttc atg tcc acc tcc tcg ggc agc cta tgg      451
 Ser Tyr Ala Lys Leu Val Phe Met Ser Thr Ser Ser Gly Ser Leu Trp
                  25                  30                  35

 aac ctg cat gcc atc cat tcc atg tgt cgc atg gaa cag gac cag atc      499
 Asn Leu His Ala Ile His Ser Met Cys Arg Met Glu Gln Asp Gln Ile
              40                  45                  50

 cgc tcc cat acc agc ttc ggg gct ctg tgc cag cgg aca gca gcc aac      547
 Arg Ser His Thr Ser Phe Gly Ala Leu Cys Gln Arg Thr Ala Ala Asn
          55                  60                  65

 cag tgc tgc ccc agc tgg tcc ctg ggc aac tat ctg gct gtg ctc tcc      595
 Gln Cys Cys Pro Ser Trp Ser Leu Gly Asn Tyr Leu Ala Val Leu Ser
      70                  75                  80

 aac cgc tcc tcc tgc ctg gac act acc caa gct gac gca gcc cgc aca      643
 Asn Arg Ser Ser Cys Leu Asp Thr Thr Gln Ala Asp Ala Ala Arg Thr
  85                  90                  95                 100

 ctg gcc ctg ctt cgg acc tgt gcc ctc tac tac cac agt ggc gcc ttg      691
 Leu Ala Leu Leu Arg Thr Cys Ala Leu Tyr Tyr His Ser Gly Ala Leu
                 105                 110                 115

 gtg ccc tct tgt ctg gga cct ggg cag aac aag tcc cca cgc tgt gcc      739
 Val Pro Ser Cys Leu Gly Pro Gly Gln Asn Lys Ser Pro Arg Cys Ala
             120                 125                 130

 cag gtt ccc acc aag tgc tcc cag agt agt gcc atc tac caa ctc ctg      787
 Gln Val Pro Thr Lys Cys Ser Gln Ser Ser Ala Ile Tyr Gln Leu Leu
         135                 140                 145

 cac ttt ctg ctt gac agg gac ttt ctg agt ccc cag acc act gac tac      835
 His Phe Leu Leu Asp Arg Asp Phe Leu Ser Pro Gln Thr Thr Asp Tyr
     150                 155                 160

 cag gtg cct tcc ctc aag tac agc ctg ctc ttc ctg ccc acc cca aag      883
 Gln Val Pro Ser Leu Lys Tyr Ser Leu Leu Phe Leu Pro Thr Pro Lys
 165                 170                 175                 180

 ggt gct tcc ctc atg gac atc tac ctg gac cgg ctg gcc acc ccc tgg      931
 Gly Ala Ser Leu Met Asp Ile Tyr Leu Asp Arg Leu Ala Thr Pro Trp
                 185                 190                 195

 ggg ctt gct gac aac tac acc tct gtc act ggc atg gac ctg ggc ctc      979
 Gly Leu Ala Asp Asn Tyr Thr Ser Val Thr Gly Met Asp Leu Gly Leu
             200                 205                 210

 aag cag gag ctg ctg agg cac ttc ctg gtc cag gac acg gtg tac ccc     1027
 Lys Gln Glu Leu Leu Arg His Phe Leu Val Gln Asp Thr Val Tyr Pro
         215                 220                 225

 ttg ctg gct ctg gtt gcc atc ttc ttc ggc atg gcc ctg tac ctg cgc     1075
 Leu Leu Ala Leu Val Ala Ile Phe Phe Gly Met Ala Leu Tyr Leu Arg
     230                 235                 240

 tca ctc ttc ctc acg ctc atg gtg ctg ctg ggg gtg ctg ggc tca ctg     1123
 Ser Leu Phe Leu Thr Leu Met Val Leu Leu Gly Val Leu Gly Ser Leu
 245                 250                 255                 260

 ctg gtg gcc ttc ttc ctt tac cag gtg gcc ttc cgc atg gcc tac ttc     1171
 Leu Val Ala Phe Phe Leu Tyr Gln Val Ala Phe Arg Met Ala Tyr Phe
                 265                 270                 275

 ccc ttc gtc aat ctg gca gcc ctc ctc ctg ctg agc agc gtc tgc gcc     1219
 Pro Phe Val Asn Leu Ala Ala Leu Leu Leu Leu Ser Ser Val Cys Ala
             280                 285                 290

 aac cac acg ctc atc ttc ttc gac ctg tgg cgc ctt agc aag agc cag     1267
 Asn His Thr Leu Ile Phe Phe Asp Leu Trp Arg Leu Ser Lys Ser Gln
         295                 300                 305

 ctg ccg tcg ggg ggg ctg gcg cag cgc gtg ggc cgc acc atg cac cac     1315
 Leu Pro Ser Gly Gly Leu Ala Gln Arg Val Gly Arg Thr Met His His
     310                 315                 320

 ttc ggc tac ctg ctg ctg gtc tcc ggc ctc acc acg agc gcg gcc ttc     1363
 Phe Gly Tyr Leu Leu Leu Val Ser Gly Leu Thr Thr Ser Ala Ala Phe
 325                 330                 335                 340

 tat gcc agc tac ctg agc cgc ctg ccg gcc gtt cgc tgc ctc gcc ctc     1411
 Tyr Ala Ser Tyr Leu Ser Arg Leu Pro Ala Val Arg Cys Leu Ala Leu
                 345                 350                 355

 ttc atg ggc acg gct gtg ctg gtg cac ctg gcg ctc acg ctg gtc tgg     1459
 Phe Met Gly Thr Ala Val Leu Val His Leu Ala Leu Thr Leu Val Trp
             360                 365                 370

 ctg ccc gcc tcc gcc gtg ctc cac gag cgc tac ctg gcg cgc ggc tgt     1507
 Leu Pro Ala Ser Ala Val Leu His Glu Arg Tyr Leu Ala Arg Gly Cys
         375                 380                 385

 gcg cgc cgg gcg cgg ggc cgg tgg gag ggc agc gcg ccc cgg cgg cta     1555
 Ala Arg Arg Ala Arg Gly Arg Trp Glu Gly Ser Ala Pro Arg Arg Leu
     390                 395                 400

 ctg ctg gcg ctg cac cgg cgg ctc cgc ggc ctg cgg agg gcg gcg gct     1603
 Leu Leu Ala Leu His Arg Arg Leu Arg Gly Leu Arg Arg Ala Ala Ala
 405                 410                 415                 420

 ggc acc tcg cgt ctg ctc ttc cag cgc ctg ctg ccc tgc ggc gtc atc     1651
 Gly Thr Ser Arg Leu Leu Phe Gln Arg Leu Leu Pro Cys Gly Val Ile
                 425                 430                 435

 aag ttc cgc tac atc tgg atc tgc tgg ttc gca gca ctg gcg gca ggg     1699
 Lys Phe Arg Tyr Ile Trp Ile Cys Trp Phe Ala Ala Leu Ala Ala Gly
             440                 445                 450

 ggc gcc tac atc gcc gga gtc agc ccc cgc ctg cgg ctg ccc acg ctg     1747
 Gly Ala Tyr Ile Ala Gly Val Ser Pro Arg Leu Arg Leu Pro Thr Leu
         455                 460                 465

 ccg ccg ccc ggc ggc cag gtc ttc cgg ccc agc cac ccc ttc gag cgc     1795
 Pro Pro Pro Gly Gly Gln Val Phe Arg Pro Ser His Pro Phe Glu Arg
     470                 475                 480

 ttc gac gca gag tat cgc cag ctg ttc ctg ttc gag cag ctg ccg cag     1843
 Phe Asp Ala Glu Tyr Arg Gln Leu Phe Leu Phe Glu Gln Leu Pro Gln
 485                 490                 495                 500

 ggc gag ggc ggc cac atg ccc gtg gtt ttg gtg tgg ggc gtc ctg cct     1891
 Gly Glu Gly Gly His Met Pro Val Val Leu Val Trp Gly Val Leu Pro
                 505                 510                 515

 gtg gac act ggc gac cct ctg gac cct cgt agc aac agc agc ctg gtg     1939
 Val Asp Thr Gly Asp Pro Leu Asp Pro Arg Ser Asn Ser Ser Leu Val
             520                 525                 530

 agg gac cct gcc ttc tcg gcc agc ggc cct gag gcc cag cgc tgg ctg     1987
 Arg Asp Pro Ala Phe Ser Ala Ser Gly Pro Glu Ala Gln Arg Trp Leu
         535                 540                 545

 ctg gca ctc tgt cac cgg gcc cgg aat cag agc ttc ttc gac acc ctg     2035
 Leu Ala Leu Cys His Arg Ala Arg Asn Gln Ser Phe Phe Asp Thr Leu
     550                 555                 560

 cag gaa ggc tgg ccc acg ctg tgt ttc gtg gag acc ctc cag cgc tgg     2083
 Gln Glu Gly Trp Pro Thr Leu Cys Phe Val Glu Thr Leu Gln Arg Trp
 565                 570                 575                 580

 atg gag agc ccc agc tgc gcc cgc ctg ggg cct gac ctc tgc tgc ggc     2131
 Met Glu Ser Pro Ser Cys Ala Arg Leu Gly Pro Asp Leu Cys Cys Gly
                 585                 590                 595

 cac tcg gac ttc ccc tgg gcc ccc cag ttt ttc ctg cac tgc ctg aaa     2179
 His Ser Asp Phe Pro Trp Ala Pro Gln Phe Phe Leu His Cys Leu Lys
             600                 605                 610

 atg atg gct ctg gag caa ggc ccc gat ggc acc cag gac ctg gga ctc     2227
 Met Met Ala Leu Glu Gln Gly Pro Asp Gly Thr Gln Asp Leu Gly Leu
         615                 620                 625

 cgc ttt gat gcc cat ggc agc ctg gcc gcc ctg gtc cta caa ttc cag     2275
 Arg Phe Asp Ala His Gly Ser Leu Ala Ala Leu Val Leu Gln Phe Gln
     630                 635                 640

 acc aac ttc cgg aac agt ccg gac tac aac cag acc cag ctc ttc tac     2323
 Thr Asn Phe Arg Asn Ser Pro Asp Tyr Asn Gln Thr Gln Leu Phe Tyr
 645                 650                 655                 660

 aat gag gtc agc cac tgg ctg gca gcg gag ctg ggc atg gca cct cca     2371
 Asn Glu Val Ser His Trp Leu Ala Ala Glu Leu Gly Met Ala Pro Pro
                 665                 670                 675

 ggc ctc cgc cgt ggt tgg ttc act agc cgt cta gag ctg tat agc ctg     2419
 Gly Leu Arg Arg Gly Trp Phe Thr Ser Arg Leu Glu Leu Tyr Ser Leu
             680                 685                 690

 cag cac agc ctg agc act gag cct gct gtg gtg ctg ggc ctg gct ttg     2467
 Gln His Ser Leu Ser Thr Glu Pro Ala Val Val Leu Gly Leu Ala Leu
         695                 700                 705

 gcg ctg gcc ttt gcc aca ctg ctc ctg ggc acc tgg aat gtt ccc ctc     2515
 Ala Leu Ala Phe Ala Thr Leu Leu Leu Gly Thr Trp Asn Val Pro Leu
     710                 715                 720

 agc cta ttc tcc gtg gca gct gtg gca ggc acc gtg ctg ctc act gta     2563
 Ser Leu Phe Ser Val Ala Ala Val Ala Gly Thr Val Leu Leu Thr Val
 725                 730                 735                 740

 gga ctc ctg gtt ctc ctc gag tgg cag ctc aac act gcc gag gcc ctg     2611
 Gly Leu Leu Val Leu Leu Glu Trp Gln Leu Asn Thr Ala Glu Ala Leu
                 745                 750                 755

 ttt ctc tct gcc tca gtg ggc ctc tca gta gac ttc act gtc aac tac     2659
 Phe Leu Ser Ala Ser Val Gly Leu Ser Val Asp Phe Thr Val Asn Tyr
             760                 765                 770

 tgc atc tcc tat cac ctg tgc cca cac cct gac cgc ctg agc cgt gtg     2707
 Cys Ile Ser Tyr His Leu Cys Pro His Pro Asp Arg Leu Ser Arg Val
         775                 780                 785

 gcc ttc tct ctg cgc cag acc agc tgc gcc aca gcc gtg ggg gct gca     2755
 Ala Phe Ser Leu Arg Gln Thr Ser Cys Ala Thr Ala Val Gly Ala Ala
     790                 795                 800

 gcc ctg ttt gcg gca ggc gtg ctc atg ctg cct gcc aca gtg ctg ctc     2803
 Ala Leu Phe Ala Ala Gly Val Leu Met Leu Pro Ala Thr Val Leu Leu
 805                 810                 815                 820

 tat cgc aag ctg ggc atc atc ctc atg atg gtc aaa tgc gtc agt tgt     2851
 Tyr Arg Lys Leu Gly Ile Ile Leu Met Met Val Lys Cys Val Ser Cys
                 825                 830                 835

 ggc ttt gcc agc ttc ttc ttc caa tct ctc tgc tgt ttc ttc ggg cca     2899
 Gly Phe Ala Ser Phe Phe Phe Gln Ser Leu Cys Cys Phe Phe Gly Pro
             840                 845                 850

 gag aag aac tgt ggg cag atc ctc tgg ccc tgt gcc cac ctg cca tgg     2947
 Glu Lys Asn Cys Gly Gln Ile Leu Trp Pro Cys Ala His Leu Pro Trp
         855                 860                 865

 gat gct ggt act ggg gac cct ggt ggg gag aag gca ggc cgc cca cga     2995
 Asp Ala Gly Thr Gly Asp Pro Gly Gly Glu Lys Ala Gly Arg Pro Arg
     870                 875                 880

 cca ggg tca gtg gga ggg atg ccc ggg tcc tgc tca gag caa tat gag     3043
 Pro Gly Ser Val Gly Gly Met Pro Gly Ser Cys Ser Glu Gln Tyr Glu
 885                 890                 895                 900

 cta cag ccc ctg gca cgg cgt cgg agc ccc agc ttt gac acc agc aca     3091
 Leu Gln Pro Leu Ala Arg Arg Arg Ser Pro Ser Phe Asp Thr Ser Thr
                 905                 910                 915

 gcc acc agc aag ctg tcc cac cgg ccc tca gta ctc tct gag gat ctg     3139
 Ala Thr Ser Lys Leu Ser His Arg Pro Ser Val Leu Ser Glu Asp Leu
             920                 925                 930

 cag ctc cat gat ggt ccg tgc tgt tcc cgg ccc cca cca gcc cct gcc     3187
 Gln Leu His Asp Gly Pro Cys Cys Ser Arg Pro Pro Pro Ala Pro Ala
         935                 940                 945

 tcc cca agg gag ctg ctg ctg gac cac cag gca gtc ttc agc cag tgc     3235
 Ser Pro Arg Glu Leu Leu Leu Asp His Gln Ala Val Phe Ser Gln Cys
     950                 955                 960

 cct gcc ctg cag acc tcc tcc ccc tat aag cag gct ggc ccc agc ccc     3283
 Pro Ala Leu Gln Thr Ser Ser Pro Tyr Lys Gln Ala Gly Pro Ser Pro
 965                 970                 975                 980

 aaa acc cgg gcc agg cag gac tcc caa ggg gag gag gct gag ccc ctg     3331
 Lys Thr Arg Ala Arg Gln Asp Ser Gln Gly Glu Glu Ala Glu Pro Leu
                 985                 990                 995

 cca gcc tca cca gaa gcc cca gcc cac tct cct aag gcc aag gct gca     3379
 Pro Ala Ser Pro Glu Ala Pro Ala His Ser Pro Lys Ala Lys Ala Ala
            1000                1005                1010

 gat cct cct gat ggc ttc tgt tcc tca gcc agc acc ctg gag ggg ctc     3427
 Asp Pro Pro Asp Gly Phe Cys Ser Ser Ala Ser Thr Leu Glu Gly Leu
        1015                1020                1025

 agc gtc tct gat gag acc tgc cta agc acc tct gag ccc agt gcc cgt     3475
 Ser Val Ser Asp Glu Thr Cys Leu Ser Thr Ser Glu Pro Ser Ala Arg
    1030                1035                1040

 gta cca gat tcc gtg ggt gtg tcc cca gat gac ctg gat gac act ggg     3523
 Val Pro Asp Ser Val Gly Val Ser Pro Asp Asp Leu Asp Asp Thr Gly
1045                1050                1055                1060

 cag cca gtc ctt gag cga ggc cag ctc aat ggg aag cgg gac acc ctg     3571
 Gln Pro Val Leu Glu Arg Gly Gln Leu Asn Gly Lys Arg Asp Thr Leu
                1065                1070                1075

 tgg ctg gcg ctg agg gag aca gtg tat gac cca tca ttg ccc gct tcc     3619
 Trp Leu Ala Leu Arg Glu Thr Val Tyr Asp Pro Ser Leu Pro Ala Ser
            1080                1085                1090

 cat cac agc agc ttg tcc tgg aag ggc cga ggg ggg cca ggg gat ggc     3667
 His His Ser Ser Leu Ser Trp Lys Gly Arg Gly Gly Pro Gly Asp Gly
        1095                1100                1105

 agc cct gtg gtg ctg ccc aat agc cag cca gac ctg cca gat gtt tgg     3715
 Ser Pro Val Val Leu Pro Asn Ser Gln Pro Asp Leu Pro Asp Val Trp
    1110                1115                1120

 ctg cgc agg ccc agc act cac aca tca ggc tat agc agc tga gggggac     3764
 Leu Arg Arg Pro Ser Thr His Thr Ser Gly Tyr Ser Ser 
1125                1130                1135

 ccggggaggc tggacagggc gcggaaccct gtcatggatg acaaggcaag ggcagcaata   3824

 ggctggagcc cgaaggtatt tctccagatc cacagggaga ggtctcaccc tccagctgtg   3884

 gatgttaaac cctgccagat gtcccagcct tgatctgtct gctcctactc ctcacatctg   3944

 gaggattcca gcaggagggg ttttggaggg gacctgcttg cgacctgctg agggcttgtc   4004

 tgctcccaca gcaccatcta agacccctcc tctagaagtg gggaaggcca gatgtgtagc   4064

 ttcgggtatc agaggaggct gacctggccc ccatcccaag ttacaagaac ttcagtgaga   4124

 ctaagggacc cccatcctag ggatcttgtc agggttcctt actgaccaga ggagcccgca   4184

 gcaatctcca cagcctcctg ggtctcaccc ctttcatggg ctcttcatca ggacacttcc   4244

 ctctcttttg ggagcttctc tgggcagaat tgggctggga cctctctccc caactgccct   4304

 gctctcctca tactcaccgg tttgaccaga aattctccaa atccagccat agatggctgc   4364

 tgggtgtgca gcaggagaag gaggatggtc agccttggag catctctcaa ttacgggaca   4424

 gtccctcttt ggaagcaggc tcctgtgctt tcctgtgtta ataaacagta ataatccttt   4484

 ccaaaaaaaa aaaaa                                                    4499




      <210> 270
      <211> 788
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(783)

      <400> 270
 ctagggtttc tgagc atg aat cca acc atc cca gcc ttg gat aca gaa att      51
                  Met Asn Pro Thr Ile Pro Ala Leu Asp Thr Glu Ile
                    1               5                  10

 gca cca att agt gat aca gag gag acc cat cct cat cgt tgt ggc atg       99
 Ala Pro Ile Ser Asp Thr Glu Glu Thr His Pro His Arg Cys Gly Met
          15                  20                  25

 gag gtc ctg gtc ctc ata gtg ctg atc ctc atc att gac ctg gtc ggg      147
 Glu Val Leu Val Leu Ile Val Leu Ile Leu Ile Ile Asp Leu Val Gly
      30                  35                  40

 ctg gca gga aat gca gtc atg ctc tgg ctc ctg ggc ttc tgc atg cac      195
 Leu Ala Gly Asn Ala Val Met Leu Trp Leu Leu Gly Phe Cys Met His
  45                  50                  55                  60

 agt aac acc ttc tct ctc tac atc ctc aac ctg gcc agg gct gac ttc      243
 Ser Asn Thr Phe Ser Leu Tyr Ile Leu Asn Leu Ala Arg Ala Asp Phe
                  65                  70                  75

 ctc tgc acc tgc ttc cag att ata aca ttc att aat ttc ttc agt gac      291
 Leu Cys Thr Cys Phe Gln Ile Ile Thr Phe Ile Asn Phe Phe Ser Asp
              80                  85                  90

 ttt gtt agt tct ctc tcc atc cat ttc tct aga ttt gtc acc acg gtg      339
 Phe Val Ser Ser Leu Ser Ile His Phe Ser Arg Phe Val Thr Thr Val
          95                 100                 105

 ttg ttc tcc gcc tgt att aca ggc ctg agc atg ctg agc acc atc agc      387
 Leu Phe Ser Ala Cys Ile Thr Gly Leu Ser Met Leu Ser Thr Ile Ser
     110                 115                 120

 acc gag cac cgc ctg tcc gtc ctg tgg ccc atc tgg tac tgc tgc cac      435
 Thr Glu His Arg Leu Ser Val Leu Trp Pro Ile Trp Tyr Cys Cys His
 125                 130                 135                 140

 tgc ccc aca cac ctg tca gcg gtc atg tgt gtc ctg ctc tgg gcc ctg      483
 Cys Pro Thr His Leu Ser Ala Val Met Cys Val Leu Leu Trp Ala Leu
                 145                 150                 155

 tcc ctg ttg cag agc atc ctg gag tgg atg ttc tgt agc ttc ctg ttt      531
 Ser Leu Leu Gln Ser Ile Leu Glu Trp Met Phe Cys Ser Phe Leu Phe
             160                 165                 170

 agt gat gtt gac tct gat aat tgg tgt caa ata tta gat ttc ctc act      579
 Ser Asp Val Asp Ser Asp Asn Trp Cys Gln Ile Leu Asp Phe Leu Thr
         175                 180                 185

 gct gtg tgg ctg att ttt tta atc tgt ggt tct ctg tgg gtt cac cct      627
 Ala Val Trp Leu Ile Phe Leu Ile Cys Gly Ser Leu Trp Val His Pro
     190                 195                 200

 ggt cct gct tgt cag gat cat atg tgg atc cca gaa gat gcc gct gac      675
 Gly Pro Ala Cys Gln Asp His Met Trp Ile Pro Glu Asp Ala Ala Asp
 205                 210                 215                 220

 cag gct gta tgt gac cat cct gct cac agg gct ggt ctt cct ctt ctg      723
 Gln Ala Val Cys Asp His Pro Ala His Arg Ala Gly Leu Pro Leu Leu
                 225                 230                 235

 cag cct gcc cct cag cat tca gtg att cct att ata ctg gat cga gaa      771
 Gln Pro Ala Pro Gln His Ser Val Ile Pro Ile Ile Leu Asp Arg Glu
             240                 245                 250

 gga ttt gga tga cttac                                                788
 Gly Phe Gly 
         255





      <210> 271
      <211> 6924
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(6359)

      <400> 271
 ctagcccagc cccgcgg   atg aca gga gcc ggg gag ccg agg agg gag gag      50
                      Met Thr Gly Ala Gly Glu Pro Arg Arg Glu Glu
                        1               5                  10

 ccg ccg ccg cag ccg agc gct ggg ctg agg agc aga gag agc ggg gcg       98
 Pro Pro Pro Gln Pro Ser Ala Gly Leu Arg Ser Arg Glu Ser Gly Ala
              15                  20                  25

 ccg agt gcg ggc ggc tgg gag cgc gct gag cgg ggg aga ggc gct gcc      146
 Pro Ser Ala Gly Gly Trp Glu Arg Ala Glu Arg Gly Arg Gly Ala Ala
          30                  35                  40

 gca cgg ccg gcc aca gga cca cct ccc cgg aga ata ggg cct ctt tat      194
 Ala Arg Pro Ala Thr Gly Pro Pro Pro Arg Arg Ile Gly Pro Leu Tyr
      45                  50                  55

 ggc atg tgg ctg gta act ttc ctc ctg ctc ctg gac tct tta cac aaa      242
 Gly Met Trp Leu Val Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys
  60                  65                  70                  75

 gcc cgc cct gaa gat gtt ggc acc agc ctc tac ttt gta aat gac tcc      290
 Ala Arg Pro Glu Asp Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser
                  80                  85                  90

 ttg cag cag gtg acc ttt tcc agc tcc gtg ggg gtg gtg gtg ccc tgc      338
 Leu Gln Gln Val Thr Phe Ser Ser Ser Val Gly Val Val Val Pro Cys
              95                 100                 105

 ccg gcc gcg ggc tcc ccc agc gcg gcc ctt cga tgg tac ctg gcc aca      386
 Pro Ala Ala Gly Ser Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr
         110                 115                 120

 ggg gac gac atc tac gac gtg ccg cac atc cgg cac gtc cac gcc aac      434
 Gly Asp Asp Ile Tyr Asp Val Pro His Ile Arg His Val His Ala Asn
     125                 130                 135

 ggg acg ctg cag ctc tac ccc ttc tcc ccc tcc gcc ttc aat agc ttt      482
 Gly Thr Leu Gln Leu Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe
 140                 145                 150                 155

 atc cac gac aat gac tac ttc tgc acc gcg gag aac gct gcc ggc aag      530
 Ile His Asp Asn Asp Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys
                 160                 165                 170

 atc cgg agc ccc aac atc cgc gtc aaa gca gtt ttc agg gaa ccc tac      578
 Ile Arg Ser Pro Asn Ile Arg Val Lys Ala Val Phe Arg Glu Pro Tyr
             175                 180                 185

 acc gtc cgg gtg gag gat caa agg tca atg cgt ggc aac gtg gcc gtc      626
 Thr Val Arg Val Glu Asp Gln Arg Ser Met Arg Gly Asn Val Ala Val
         190                 195                 200

 ttc aag tgc ctc atc ccc tct tca gtg cag gaa tat gtt agc gtt gta      674
 Phe Lys Cys Leu Ile Pro Ser Ser Val Gln Glu Tyr Val Ser Val Val
     205                 210                 215

 tct tgg gag aaa gac aca gtc tcc atc atc cca gaa cac agg ttt ttt      722
 Ser Trp Glu Lys Asp Thr Val Ser Ile Ile Pro Glu His Arg Phe Phe
 220                 225                 230                 235

 att acc tac cac ggc ggg ctg tac atc tct gac gta cag aag gag gac      770
 Ile Thr Tyr His Gly Gly Leu Tyr Ile Ser Asp Val Gln Lys Glu Asp
                 240                 245                 250

 gcc ctc tcc acc tat cgc tgc atc acc aag cac aag tat agc ggg gag      818
 Ala Leu Ser Thr Tyr Arg Cys Ile Thr Lys His Lys Tyr Ser Gly Glu
             255                 260                 265

 acc cgg cag agc aat ggg gca cgc ctc tct gtg aca gac cct gct gag      866
 Thr Arg Gln Ser Asn Gly Ala Arg Leu Ser Val Thr Asp Pro Ala Glu
         270                 275                 280

 tcg atc ccc acc atc ctg gat ggc ttc cac tcc cag gaa gtg tgg gcc      914
 Ser Ile Pro Thr Ile Leu Asp Gly Phe His Ser Gln Glu Val Trp Ala
     285                 290                 295

 ggc cac acc gtg gag ctg ccc tgc acc gcc tcg ggc tac cct atc ccc      962
 Gly His Thr Val Glu Leu Pro Cys Thr Ala Ser Gly Tyr Pro Ile Pro
 300                 305                 310                 315

 gcc atc cgc tgg ctc aag gat ggc cgg ccc ctc ccg gct gac agc cgc     1010
 Ala Ile Arg Trp Leu Lys Asp Gly Arg Pro Leu Pro Ala Asp Ser Arg
                 320                 325                 330

 tgg acc aag cgc atc aca ggg ctg acc atc agc gac ttg cgg acc gag     1058
 Trp Thr Lys Arg Ile Thr Gly Leu Thr Ile Ser Asp Leu Arg Thr Glu
             335                 340                 345

 gac agc ggc acc tac att tgt gag gtc acc aac acc ttc ggt tcg gca     1106
 Asp Ser Gly Thr Tyr Ile Cys Glu Val Thr Asn Thr Phe Gly Ser Ala
         350                 355                 360

 gag gcc aca ggc atc ctc atg gtc att gat ccc ctt cat gtg acc ctg     1154
 Glu Ala Thr Gly Ile Leu Met Val Ile Asp Pro Leu His Val Thr Leu
     365                 370                 375

 aca cca aag aag ctg aag acc ggc att ggc agc acg gtc atc ctc tcc     1202
 Thr Pro Lys Lys Leu Lys Thr Gly Ile Gly Ser Thr Val Ile Leu Ser
 380                 385                 390                 395

 tgt gcc ctg acg ggc tcc cca gag ttc acc atc cgc tgg tat cgc aac     1250
 Cys Ala Leu Thr Gly Ser Pro Glu Phe Thr Ile Arg Trp Tyr Arg Asn
                 400                 405                 410

 acg gag ctg gtg ctg cct gac gag gcc atc tcc atc cgc ggg ctc agc     1298
 Thr Glu Leu Val Leu Pro Asp Glu Ala Ile Ser Ile Arg Gly Leu Ser
             415                 420                 425

 aac gag acg ctg ctc atc acc tcg gcc cag aag agc cat tcc ggg gcc     1346
 Asn Glu Thr Leu Leu Ile Thr Ser Ala Gln Lys Ser His Ser Gly Ala
         430                 435                 440

 tac cag tgc ttc gct acc cgc aag gcc cag acc gcc cag gac ttt gcc     1394
 Tyr Gln Cys Phe Ala Thr Arg Lys Ala Gln Thr Ala Gln Asp Phe Ala
     445                 450                 455

 atc att gca ctt gag gat ggc acg ccc cgc atc gtc tcg tcc ttc agc     1442
 Ile Ile Ala Leu Glu Asp Gly Thr Pro Arg Ile Val Ser Ser Phe Ser
 460                 465                 470                 475

 gag aag gtg gtc aac ccc ggg gag cag ttc tca ctg atg tgt gcg gcc     1490
 Glu Lys Val Val Asn Pro Gly Glu Gln Phe Ser Leu Met Cys Ala Ala
                 480                 485                 490

 aag ggc gcc ccg ccc ccc acg gtc acc tgg gcc ctc gac gat gag ccc     1538
 Lys Gly Ala Pro Pro Pro Thr Val Thr Trp Ala Leu Asp Asp Glu Pro
             495                 500                 505

 atc gtg cgg gat ggc agc cac cgc acc aac cag tac acc atg tcg gac     1586
 Ile Val Arg Asp Gly Ser His Arg Thr Asn Gln Tyr Thr Met Ser Asp
         510                 515                 520

 ggc acc acc atc agc cac atg aac gtc aca ggc ccc cag atc cgc gac     1634
 Gly Thr Thr Ile Ser His Met Asn Val Thr Gly Pro Gln Ile Arg Asp
     525                 530                 535

 ggg ggc gtg tac cgg tgc aca gcg cgg aac ttg gtg ggc agt gct gaa     1682
 Gly Gly Val Tyr Arg Cys Thr Ala Arg Asn Leu Val Gly Ser Ala Glu
 540                 545                 550                 555

 tat cag gcg cga ata aac gta aga ggc cca ccc agc atc cgg gct atg     1730
 Tyr Gln Ala Arg Ile Asn Val Arg Gly Pro Pro Ser Ile Arg Ala Met
                 560                 565                 570

 cgg aac atc aca gca gtc gcc ggg cgg gac acc ctt atc aac tgc agg     1778
 Arg Asn Ile Thr Ala Val Ala Gly Arg Asp Thr Leu Ile Asn Cys Arg
             575                 580                 585

 gtc atc ggc tat ccc tac tac tcc atc aag tgg tac aag gat gcc ctg     1826
 Val Ile Gly Tyr Pro Tyr Tyr Ser Ile Lys Trp Tyr Lys Asp Ala Leu
         590                 595                 600

 ctg ctg cca gac aac cac cgc cag gtg gtg ttt gag aat ggg acc ctc     1874
 Leu Leu Pro Asp Asn His Arg Gln Val Val Phe Glu Asn Gly Thr Leu
     605                 610                 615

 aag ctg act gac gtg cag aag ggc atg gat gag ggg gag tac ctg tgc     1922
 Lys Leu Thr Asp Val Gln Lys Gly Met Asp Glu Gly Glu Tyr Leu Cys
 620                 625                 630                 635

 agt gtc ctc atc cag ccc cag ctc tcc atc agc cag agc gtt cac gta     1970
 Ser Val Leu Ile Gln Pro Gln Leu Ser Ile Ser Gln Ser Val His Val
                 640                 645                 650

 gcc gtc aaa gtg ccc cct ctg atc cag ccc ttc gaa ttc cca ccc gcc     2018
 Ala Val Lys Val Pro Pro Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala
             655                 660                 665

 tcc atc ggc cag ctg ctc tac att ccc tgt gtg gtg tcc tcg ggg gac     2066
 Ser Ile Gly Gln Leu Leu Tyr Ile Pro Cys Val Val Ser Ser Gly Asp
         670                 675                 680

 atg ccc atc cgt atc acc tgg agg aag gac gga cag gtg atc atc tca     2114
 Met Pro Ile Arg Ile Thr Trp Arg Lys Asp Gly Gln Val Ile Ile Ser
     685                 690                 695

 ggc tcg ggc gtg acc atc gag agc aag gaa ttc atg agc tcc ctg cag     2162
 Gly Ser Gly Val Thr Ile Glu Ser Lys Glu Phe Met Ser Ser Leu Gln
 700                 705                 710                 715

 atc tct agc gtc tcc ctc aag cac aac ggc aac tat aca tgc atc gcc     2210
 Ile Ser Ser Val Ser Leu Lys His Asn Gly Asn Tyr Thr Cys Ile Ala
                 720                 725                 730

 agc aac gca gcc gcc acc gtg agc cgg gag cgc cag ctc atc gtg cgt     2258
 Ser Asn Ala Ala Ala Thr Val Ser Arg Glu Arg Gln Leu Ile Val Arg
             735                 740                 745

 gtg ccc cct cga ttt gtg gtg caa ccc aac aac cag gat ggc atc tac     2306
 Val Pro Pro Arg Phe Val Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr
         750                 755                 760

 ggc aaa gct ggt gtg ctc aac tgc tcg gtg gac ggc tac ccc cca ccc     2354
 Gly Lys Ala Gly Val Leu Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro
     765                 770                 775

 aag gtc atg tgg aag cat gcc aag ggg agc ggg aac ccc cag cag tac     2402
 Lys Val Met Trp Lys His Ala Lys Gly Ser Gly Asn Pro Gln Gln Tyr
 780                 785                 790                 795

 cac cct gtg ccc ctc act ggc cgc atc cag atc ctg ccc aac agc tcg     2450
 His Pro Val Pro Leu Thr Gly Arg Ile Gln Ile Leu Pro Asn Ser Ser
                 800                 805                 810

 ctg ctg atc cgc cac gtc cta gaa gag gac atc ggc tac tac ctc tgc     2498
 Leu Leu Ile Arg His Val Leu Glu Glu Asp Ile Gly Tyr Tyr Leu Cys
             815                 820                 825

 cag gcc agc aac ggc gta ggc acc gac atc agc aag tcc atg ttc ctc     2546
 Gln Ala Ser Asn Gly Val Gly Thr Asp Ile Ser Lys Ser Met Phe Leu
         830                 835                 840

 aca gtc aag atc ccg gcc atg atc act tcc cac ccc aac acc acc atc     2594
 Thr Val Lys Ile Pro Ala Met Ile Thr Ser His Pro Asn Thr Thr Ile
     845                 850                 855

 gcc atc aag ggc cat gcg aag gag cta aac tgc acg gca cgg ggt gag     2642
 Ala Ile Lys Gly His Ala Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu
 860                 865                 870                 875

 cgg ccc atc atc atc cgc tgg gag aag ggg gac aca gtc atc gac cct     2690
 Arg Pro Ile Ile Ile Arg Trp Glu Lys Gly Asp Thr Val Ile Asp Pro
                 880                 885                 890

 gac cgc gtc atg cgg tat gcc atc gcc acc aag gac aac ggc gac gag     2738
 Asp Arg Val Met Arg Tyr Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu
             895                 900                 905

 gtc gtc tcc aca ctg aag ctc aag ccc gct gac cgt ggg gac tct gtg     2786
 Val Val Ser Thr Leu Lys Leu Lys Pro Ala Asp Arg Gly Asp Ser Val
         910                 915                 920

 ttc ttc agc tgc cat gcc atc aac tcg tat ggg gag gac cgg ggc ttg     2834
 Phe Phe Ser Cys His Ala Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu
     925                 930                 935

 atc caa ctc act gtg caa gag ccc ccc gac ccc cca gag ctg gag atc     2882
 Ile Gln Leu Thr Val Gln Glu Pro Pro Asp Pro Pro Glu Leu Glu Ile
 940                 945                 950                 955

 cgg gag gtg aag gcc cgg agc atg aac ctg cgc tgg acc cag cga ttc     2930
 Arg Glu Val Lys Ala Arg Ser Met Asn Leu Arg Trp Thr Gln Arg Phe
                 960                 965                 970

 gac ggg aac agc atc atc acg ggc ttc gac att gaa tac aag aac aaa     2978
 Asp Gly Asn Ser Ile Ile Thr Gly Phe Asp Ile Glu Tyr Lys Asn Lys
             975                 980                 985

 tca gat tcc tgg gac ttc aag cag tcc aca cgc aac atc tcc ccc acc     3026
 Ser Asp Ser Trp Asp Phe Lys Gln Ser Thr Arg Asn Ile Ser Pro Thr
         990                 995                1000

 atc aac cag gcc aac att gtg gac ttg cac ccg gca tct gtg tac agc     3074
 Ile Asn Gln Ala Asn Ile Val Asp Leu His Pro Ala Ser Val Tyr Ser
    1005                1010                1015

 atc cgc atg tac tct ttc aac aag att ggc cgc agt gaa cca agc aag     3122
 Ile Arg Met Tyr Ser Phe Asn Lys Ile Gly Arg Ser Glu Pro Ser Lys
1020                1025                1030                1035

 gag ctc acc atc agc act gag gag gcc gct ccc gat ggg ccc ccc atg     3170
 Glu Leu Thr Ile Ser Thr Glu Glu Ala Ala Pro Asp Gly Pro Pro Met
                1040                1045                1050

 gat gtt acc ttg cag cca gtg acc tca cag agc atc cag gtg acc tgg     3218
 Asp Val Thr Leu Gln Pro Val Thr Ser Gln Ser Ile Gln Val Thr Trp
            1055                1060                1065

 aag gca ccc aag aag gag ctg cag aac ggt gtc atc cgg ggc tac cag     3266
 Lys Ala Pro Lys Lys Glu Leu Gln Asn Gly Val Ile Arg Gly Tyr Gln
        1070                1075                1080

 att ggc tac aga gag aac agc ccc ggc agc aac ggg cag tac agc atc     3314
 Ile Gly Tyr Arg Glu Asn Ser Pro Gly Ser Asn Gly Gln Tyr Ser Ile
    1085                1090                1095

 gtg gag atg aag gcc acg ggg gac agc gag gtc tac acc ctg gac aac     3362
 Val Glu Met Lys Ala Thr Gly Asp Ser Glu Val Tyr Thr Leu Asp Asn
1100                1105                1110                1115

 ctc aag aag ttc gcc cag tat ggg gtg gtg gtc caa gcc ttc aat cgg     3410
 Leu Lys Lys Phe Ala Gln Tyr Gly Val Val Val Gln Ala Phe Asn Arg
                1120                1125                1130

 gct ggc acg ggg ccc tct tcc agc gag atc aat gcc acc act ctg gag     3458
 Ala Gly Thr Gly Pro Ser Ser Ser Glu Ile Asn Ala Thr Thr Leu Glu
            1135                1140                1145

 gat gtg ccc agc cag ccc cct gag aac gtc cgg gcc ctg tcc atc act     3506
 Asp Val Pro Ser Gln Pro Pro Glu Asn Val Arg Ala Leu Ser Ile Thr
        1150                1155                1160

 tct gac gtg gcc gtc atc tcc tgg tca gag ccc ccg cgc agc acc ctc     3554
 Ser Asp Val Ala Val Ile Ser Trp Ser Glu Pro Pro Arg Ser Thr Leu
    1165                1170                1175

 aat ggc gtc ctc aaa ggc tat cgg gtc atc ttc tgg tcc ctc tat gtt     3602
 Asn Gly Val Leu Lys Gly Tyr Arg Val Ile Phe Trp Ser Leu Tyr Val
1180                1185                1190                1195

 gat ggg gag tgg ggc gag atg cag aac atc acc acc acg cgg gag cgg     3650
 Asp Gly Glu Trp Gly Glu Met Gln Asn Ile Thr Thr Thr Arg Glu Arg
                1200                1205                1210

 gtg gag ctg cgg ggc atg gag aag ttc acc aac tac agc gtc cag gtg     3698
 Val Glu Leu Arg Gly Met Glu Lys Phe Thr Asn Tyr Ser Val Gln Val
            1215                1220                1225

 ctg gcc tac acc cag gct ggg gac ggc gta cgc agc agt gtg ctc tac     3746
 Leu Ala Tyr Thr Gln Ala Gly Asp Gly Val Arg Ser Ser Val Leu Tyr
        1230                1235                1240

 atc cag acc aag gag gac gtt cca ggt ccc cct gct ggc atc aaa gct     3794
 Ile Gln Thr Lys Glu Asp Val Pro Gly Pro Pro Ala Gly Ile Lys Ala
    1245                1250                1255

 gtc cct tca tca gct agc agt gtg gtt gtg tct tgg ctc ccc cct acc     3842
 Val Pro Ser Ser Ala Ser Ser Val Val Val Ser Trp Leu Pro Pro Thr
1260                1265                1270                1275

 aag ccc aac ggg gtg atc cgc aag tac acc atc ttc tgt tcc agc ccc     3890
 Lys Pro Asn Gly Val Ile Arg Lys Tyr Thr Ile Phe Cys Ser Ser Pro
                1280                1285                1290

 ggg tct ggc cag ccg gct ccc agc gag tac gag acg agt cca gag cag     3938
 Gly Ser Gly Gln Pro Ala Pro Ser Glu Tyr Glu Thr Ser Pro Glu Gln
            1295                1300                1305

 ctc ttc tac cgg atc gcc cac cta aac cgc ggt cag cag tat ctg ctg     3986
 Leu Phe Tyr Arg Ile Ala His Leu Asn Arg Gly Gln Gln Tyr Leu Leu
        1310                1315                1320

 tgg gtg gcc gcc gtc acc tct gcc ggc cgg ggc aac agc agc gag aag     4034
 Trp Val Ala Ala Val Thr Ser Ala Gly Arg Gly Asn Ser Ser Glu Lys
    1325                1330                1335

 gtg acc atc gag cct gct ggc aag gcc cca gca aag atc atc tcc ttt     4082
 Val Thr Ile Glu Pro Ala Gly Lys Ala Pro Ala Lys Ile Ile Ser Phe
1340                1345                1350                1355

 ggg ggc acc gtg aca aca cct tgg atg aaa gat gtt cgg ctg cct tgc     4130
 Gly Gly Thr Val Thr Thr Pro Trp Met Lys Asp Val Arg Leu Pro Cys
                1360                1365                1370

 aat tca gtg gga gat cca gcc cct gct gtg aag tgg acc aag gac agt     4178
 Asn Ser Val Gly Asp Pro Ala Pro Ala Val Lys Trp Thr Lys Asp Ser
            1375                1380                1385

 gaa gac tcg gcc att cca gtg tcc atg gat ggg cac cgg ctc atc cac     4226
 Glu Asp Ser Ala Ile Pro Val Ser Met Asp Gly His Arg Leu Ile His
        1390                1395                1400

 acc aat ggc aca ctg ctg ctg cgt gca gtg aag gct gag gac tct ggc     4274
 Thr Asn Gly Thr Leu Leu Leu Arg Ala Val Lys Ala Glu Asp Ser Gly
    1405                1410                1415

 tac tac acg tgc acg gcc acc aac act ggt ggc ttt gac acc atc atc     4322
 Tyr Tyr Thr Cys Thr Ala Thr Asn Thr Gly Gly Phe Asp Thr Ile Ile
1420                1425                1430                1435

 gtc aac ctt ctg gtg caa gtt ccc ccg gac cag ccc cgc ctc act gtc     4370
 Val Asn Leu Leu Val Gln Val Pro Pro Asp Gln Pro Arg Leu Thr Val
                1440                1445                1450

 tcc aaa acc tca gct tcg tcc atc acc ctg acc tgg att cca ggt gac     4418
 Ser Lys Thr Ser Ala Ser Ser Ile Thr Leu Thr Trp Ile Pro Gly Asp
            1455                1460                1465

 aat ggg ggc agc tcc atc cga ggc ttc gtg cta cag tac tcg gtg gac     4466
 Asn Gly Gly Ser Ser Ile Arg Gly Phe Val Leu Gln Tyr Ser Val Asp
        1470                1475                1480

 aac agc gag gag tgg aag gat gtg ttc atc agc tcc agc gag cgc tcc     4514
 Asn Ser Glu Glu Trp Lys Asp Val Phe Ile Ser Ser Ser Glu Arg Ser
    1485                1490                1495

 ttc aag ctg gac agc ctc aag tgt ggc acg tgg tac aag gtg aag ctg     4562
 Phe Lys Leu Asp Ser Leu Lys Cys Gly Thr Trp Tyr Lys Val Lys Leu
1500                1505                1510                1515

 gca gcc aag aac agc gtg ggc tct ggg cgc atc agc gag atc atc gag     4610
 Ala Ala Lys Asn Ser Val Gly Ser Gly Arg Ile Ser Glu Ile Ile Glu
                1520                1525                1530

 gcc aag acc cac ggg cgg gag ccc tcc ttc agc aaa gac caa cac ctc     4658
 Ala Lys Thr His Gly Arg Glu Pro Ser Phe Ser Lys Asp Gln His Leu
            1535                1540                1545

 ttc acc cac atc aac tcc acg cat gct cgg ctt aac ctg cag ggc tgg     4706
 Phe Thr His Ile Asn Ser Thr His Ala Arg Leu Asn Leu Gln Gly Trp
        1550                1555                1560

 aac aat ggg ggc tgc cct atc aca gcc atc gtt ctg gag tac cgg ccc     4754
 Asn Asn Gly Gly Cys Pro Ile Thr Ala Ile Val Leu Glu Tyr Arg Pro
    1565                1570                1575

 aag ggg acc tgg gcc tgg cag ggc ctc cgg gcc aac agc tcc ggg gag     4802
 Lys Gly Thr Trp Ala Trp Gln Gly Leu Arg Ala Asn Ser Ser Gly Glu
1580                1585                1590                1595

 gtg ttt ctg acg gaa ctg cga gag gcc acg tgg tac gag ctg cgc atg     4850
 Val Phe Leu Thr Glu Leu Arg Glu Ala Thr Trp Tyr Glu Leu Arg Met
                1600                1605                1610

 agg gct tgc aac agt gcg ggc tgc ggc aat gaa aca gcc cag ttc gcc     4898
 Arg Ala Cys Asn Ser Ala Gly Cys Gly Asn Glu Thr Ala Gln Phe Ala
            1615                1620                1625

 acc ctg gac tac gat ggc agc acc att cca ccc atc aag tct gct caa     4946
 Thr Leu Asp Tyr Asp Gly Ser Thr Ile Pro Pro Ile Lys Ser Ala Gln
        1630                1635                1640

 ggt gaa ggg gat gat gtg aag aag ctg ttc acc atc ggc tgc cct gtc     4994
 Gly Glu Gly Asp Asp Val Lys Lys Leu Phe Thr Ile Gly Cys Pro Val
    1645                1650                1655

 atc ctg gcc aca ctg ggg gtg gca ctg ctc ttc atc gta cgc aag aag     5042
 Ile Leu Ala Thr Leu Gly Val Ala Leu Leu Phe Ile Val Arg Lys Lys
1660                1665                1670                1675

 agg aag gag aaa cgg ctg aag cga ctc cga gat gca aag agt ttg gca     5090
 Arg Lys Glu Lys Arg Leu Lys Arg Leu Arg Asp Ala Lys Ser Leu Ala
                1680                1685                1690

 gaa atg ttg ata agc aag aac aat aga agc ttt gac acc cct gtg aaa     5138
 Glu Met Leu Ile Ser Lys Asn Asn Arg Ser Phe Asp Thr Pro Val Lys
            1695                1700                1705

 ggg cca ccc cag ggc cca cgg cta cac att gac atc ccc agg gtc cag     5186
 Gly Pro Pro Gln Gly Pro Arg Leu His Ile Asp Ile Pro Arg Val Gln
        1710                1715                1720

 ctg ctc atc gag gac aaa gaa ggc atc aag caa ctg gga gat gac aag     5234
 Leu Leu Ile Glu Asp Lys Glu Gly Ile Lys Gln Leu Gly Asp Asp Lys
    1725                1730                1735

 gcc acc atc cct gtg aca gat gct gag ttc agc caa gct gtc aac cca     5282
 Ala Thr Ile Pro Val Thr Asp Ala Glu Phe Ser Gln Ala Val Asn Pro
1740                1745                1750                1755

 cag agc ttc tgt act ggc gtc tcc ttg cac cac cca acc ctc atc cag     5330
 Gln Ser Phe Cys Thr Gly Val Ser Leu His His Pro Thr Leu Ile Gln
                1760                1765                1770

 agc aca gga ccc ctc atc gac atg tct gac atc cgg cca gga acc aat     5378
 Ser Thr Gly Pro Leu Ile Asp Met Ser Asp Ile Arg Pro Gly Thr Asn
            1775                1780                1785

 cca gtg tcc agg aag aat gtg aag tca gcc cac agc acc cgg aac cgg     5426
 Pro Val Ser Arg Lys Asn Val Lys Ser Ala His Ser Thr Arg Asn Arg
        1790                1795                1800

 tac tca agc cag tgg acc ctg acc aag tgc cag gcc tcc aca cct gcc     5474
 Tyr Ser Ser Gln Trp Thr Leu Thr Lys Cys Gln Ala Ser Thr Pro Ala
    1805                1810                1815

 cgc acc ctc acc tcc gac tgg cgc acc gtg ggc tcc cag cat ggt gtc     5522
 Arg Thr Leu Thr Ser Asp Trp Arg Thr Val Gly Ser Gln His Gly Val
1820                1825                1830                1835

 acg gtc act gag agt gac agc tac agt gcc agc ctg tcc cag gac aca     5570
 Thr Val Thr Glu Ser Asp Ser Tyr Ser Ala Ser Leu Ser Gln Asp Thr
                1840                1845                1850

 gac aaa gga agg aac agc atg gtg tcc act gag agt gcc tct tcc acc     5618
 Asp Lys Gly Arg Asn Ser Met Val Ser Thr Glu Ser Ala Ser Ser Thr
            1855                1860                1865

 tac gag gag ctg gcc cgg gcc tat gag cat gcc aag ctg gag gag cag     5666
 Tyr Glu Glu Leu Ala Arg Ala Tyr Glu His Ala Lys Leu Glu Glu Gln
        1870                1875                1880

 ctg cag cac gcc aag ttt gag atc acc gag tgc ttc atc tct gac agt     5714
 Leu Gln His Ala Lys Phe Glu Ile Thr Glu Cys Phe Ile Ser Asp Ser
    1885                1890                1895

 tcc tct gac cag atg acc aca ggc acc aac gag aac gcc gac agc atg     5762
 Ser Ser Asp Gln Met Thr Thr Gly Thr Asn Glu Asn Ala Asp Ser Met
1900                1905                1910                1915

 aca tcc atg agc aca ccc tca gag cct ggc atc tgc cgc ttt acc gcc     5810
 Thr Ser Met Ser Thr Pro Ser Glu Pro Gly Ile Cys Arg Phe Thr Ala
                1920                1925                1930

 tca cca ccc aag ccc cag gat gcg gac cgg ggc aaa aac gtg gct gtg     5858
 Ser Pro Pro Lys Pro Gln Asp Ala Asp Arg Gly Lys Asn Val Ala Val
            1935                1940                1945

 ccc atc cct cac cgg gcc aac aag agt gac tac tgc aac ctg ccc ctg     5906
 Pro Ile Pro His Arg Ala Asn Lys Ser Asp Tyr Cys Asn Leu Pro Leu
        1950                1955                1960

 tat gcc aag tca gag gcc ttc ttt cga aag gca gat gga cgt gag ccc     5954
 Tyr Ala Lys Ser Glu Ala Phe Phe Arg Lys Ala Asp Gly Arg Glu Pro
    1965                1970                1975

 tgc ccc gtg gtc cca ccc cgt gag gcc tcc atc cgg aac ctg gct cga     6002
 Cys Pro Val Val Pro Pro Arg Glu Ala Ser Ile Arg Asn Leu Ala Arg
1980                1985                1990                1995

 acc tac cac acc cag gct cgc cac ctg acc ctg gac cct gcc agc aag     6050
 Thr Tyr His Thr Gln Ala Arg His Leu Thr Leu Asp Pro Ala Ser Lys
                2000                2005                2010

 tcc ttg ggc ctt ccc cac cca ggg gcc ccc gct gcc gcc tcc aca gcc     6098
 Ser Leu Gly Leu Pro His Pro Gly Ala Pro Ala Ala Ala Ser Thr Ala
            2015                2020                2025

 acc tta cct cag agg act ctg gcc atg cca gcc ccc cca gcc ggc aca     6146
 Thr Leu Pro Gln Arg Thr Leu Ala Met Pro Ala Pro Pro Ala Gly Thr
        2030                2035                2040

 gcc ccc cca gcc ccc ggc ccc acc cct gct gag cca ccc acc gcc ccc     6194
 Ala Pro Pro Ala Pro Gly Pro Thr Pro Ala Glu Pro Pro Thr Ala Pro
    2045                2050                2055

 agc gct gcc cct ccg gcc ccc agc acc gag cct cca cga gcc ggg ggc     6242
 Ser Ala Ala Pro Pro Ala Pro Ser Thr Glu Pro Pro Arg Ala Gly Gly
2060                2065                2070                2075

 cca cac acc aaa atg ggg ggc tcc agg gac tcg ctt ctc gag atg agc     6290
 Pro His Thr Lys Met Gly Gly Ser Arg Asp Ser Leu Leu Glu Met Ser
                2080                2085                2090

 aca tcg ggg gta ggg agg tct cag aag cag ggg gcc ggg gcc tac tcc     6338
 Thr Ser Gly Val Gly Arg Ser Gln Lys Gln Gly Ala Gly Ala Tyr Ser
            2095                2100                2105

 aaa tcc tac acc ctg gtg tag gg ccggcaggaa gagcagccac gcctgggccg     6391
 Lys Ser Tyr Thr Leu Val 
        2110

 cgccgcgccg cagccccaca cgccagctcg gctgtttttc tgcattattt atattcaact   6451

 gacagacaaa aaccaaccaa cgacaaaaca aaaaccccca atcatgaacg cctgtacata   6511

 gaactctttt gtacaaatga aactattttc ttcttctcca tgaagccagg gcacaaagaa   6571

 tttgacagta caagtcaaat cccccacccc acaaaatatg tgtggagata tatatacata   6631

 tatagacaga caggaacgcg tccacgagct atatatctat atatttctct caccctattt   6691

 tgagacagag gcacaaagac tcagcaattt ttttccctcc tcctcacctt ccccccagtc   6751

 taggtggttt tgacaaagac caaaatccca actcagagac actgcatgcg attttactgt   6811

 tccaagaaaa ccaggagttg cttcaatttg caggtgctta tgtgttaata cctttttcta   6871

 tgaaaaaaga cccagcgccg tgtgcaataa aggttatgtt tctaaaaaaa aaa          6924




      <210> 272
      <211> 1022
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (273)..(968)

      <400> 272
 atggggcgta ttgaacagct ccgggagaag agtgttgctg ggtcagggcg ctggtgtcca     60

 gcgaagggga agaagcaggc gctacatttt ggggagggag ggggaagagg cctcgtggca    120

 ggcagcagca gcagtgaagg tggctacaga attgctaatg gagtgggcca tgccatggga    180

 actgttttgg gggtgttcct ggctcgactg aagcttaaaa atgaactggt gactttagca    240

 gagaagtgag accctgcagc tgagggagca tc  atg gca gtg ttt ctg gag gcc     293
                                      Met Ala Val Phe Leu Glu Ala
                                        1               5

 aag gat gcc cat tcg gtc ctg aaa cga ttc cct cgt gcc aat gag ttc      341
 Lys Asp Ala His Ser Val Leu Lys Arg Phe Pro Arg Ala Asn Glu Phe
          10                  15                  20

 ctg gag gag ctg cgc cag ggc acc atc gag cga gag tgc atg gag gag      389
 Leu Glu Glu Leu Arg Gln Gly Thr Ile Glu Arg Glu Cys Met Glu Glu
      25                  30                  35

 atc tgc agc tac gag gag gtc aag gaa gtg ttt gag aac aaa gag aaa      437
 Ile Cys Ser Tyr Glu Glu Val Lys Glu Val Phe Glu Asn Lys Glu Lys
  40                  45                  50                  55

 acg atg gag ttc tgg aaa ggg tac cca aat gca gtc tac tct gtc cga      485
 Thr Met Glu Phe Trp Lys Gly Tyr Pro Asn Ala Val Tyr Ser Val Arg
                  60                  65                  70

 gac ccc tcg cag agc tca gat gcc atg tat gtg gtg gta ccc ctt ctg      533
 Asp Pro Ser Gln Ser Ser Asp Ala Met Tyr Val Val Val Pro Leu Leu
              75                  80                  85

 ggg gtg gca ctg ctg att gtc atc gcc ttg ttc atc atc tgg agg tgc      581
 Gly Val Ala Leu Leu Ile Val Ile Ala Leu Phe Ile Ile Trp Arg Cys
          90                  95                 100

 cag ctg cag aaa gcg acc cgt cac cac ccc tcc tat gct cag aac cgg      629
 Gln Leu Gln Lys Ala Thr Arg His His Pro Ser Tyr Ala Gln Asn Arg
     105                 110                 115

 tac cta gcc agt cgc gcc ggg cac acc ctc ccc cgg gtc atg gtg tac      677
 Tyr Leu Ala Ser Arg Ala Gly His Thr Leu Pro Arg Val Met Val Tyr
 120                 125                 130                 135

 cgg ggt act gtg cat agc caa ggg gag cct tct ggg cac cga gag gca      725
 Arg Gly Thr Val His Ser Gln Gly Glu Pro Ser Gly His Arg Glu Ala
                 140                 145                 150

 gcg agc agc ccc cag gtg gtg ctg ggg ccc agt cgg ggg ggc agg acc      773
 Ala Ser Ser Pro Gln Val Val Leu Gly Pro Ser Arg Gly Gly Arg Thr
             155                 160                 165

 aca gtc cgg cta gag agc acc ctc tac ctc cct gag ctc tct ctc tcc      821
 Thr Val Arg Leu Glu Ser Thr Leu Tyr Leu Pro Glu Leu Ser Leu Ser
         170                 175                 180

 aga ctg tcc agc acc acc cct ccc ccc tcc tac gag gag gtg act gcg      869
 Arg Leu Ser Ser Thr Thr Pro Pro Pro Ser Tyr Glu Glu Val Thr Ala
     185                 190                 195

 ccc caa gag agc agc agt gag gag gcc agc gtg tct tac agt gac cca      917
 Pro Gln Glu Ser Ser Ser Glu Glu Ala Ser Val Ser Tyr Ser Asp Pro
 200                 205                 210                 215

 ccc cca aag tac gag gag ata gtg gcc gcc aac cct ggc gct gac aag      965
 Pro Pro Lys Tyr Glu Glu Ile Val Ala Ala Asn Pro Gly Ala Asp Lys
                 220                 225                 230

 tag tggg acgtttgtgc cctgtcctgg atgaacgcct ctttccgagg tctcctattt     1022
 






      <210> 273
      <211> 542
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (53)..(502)

      <400> 273
 ggactgaagt accaactaag tcatctcctt tcaaattatc accgacacca tc    atg      55
                                                              Met
                                                                1

 gat tca agc acc gca cac agt ccg gtg ttt ctg gta ttt cct cca gaa      103
 Asp Ser Ser Thr Ala His Ser Pro Val Phe Leu Val Phe Pro Pro Glu
               5                  10                  15

 atc act gct tca gaa tat gag tcc aca gaa ctt tca gcc acg acc ttt      151
 Ile Thr Ala Ser Glu Tyr Glu Ser Thr Glu Leu Ser Ala Thr Thr Phe
          20                  25                  30

 tca act caa agc ccc ttg caa aaa tta ttt gct aga aaa atg aaa atc      199
 Ser Thr Gln Ser Pro Leu Gln Lys Leu Phe Ala Arg Lys Met Lys Ile
      35                  40                  45

 tta ggg act atc cag atc ctg ttt gga att atg acc ttt tct ttt gga      247
 Leu Gly Thr Ile Gln Ile Leu Phe Gly Ile Met Thr Phe Ser Phe Gly
  50                  55                  60                  65

 gtt atc ttc ctt ttc acc ttg tta aaa cca tat cca agg ttt ccc ttt      295
 Val Ile Phe Leu Phe Thr Leu Leu Lys Pro Tyr Pro Arg Phe Pro Phe
                  70                  75                  80

 ata ttt ctt tca gga tat cca ttc tgg ggc tct gtt ttg ttc att aat      343
 Ile Phe Leu Ser Gly Tyr Pro Phe Trp Gly Ser Val Leu Phe Ile Asn
              85                  90                  95

 tct gga gcc ttc cta att gca gtg aaa aga aaa acc aca gaa act ctg      391
 Ser Gly Ala Phe Leu Ile Ala Val Lys Arg Lys Thr Thr Glu Thr Leu
         100                 105                 110

 gga att ttg att aca ttg atg act ttc agc att att gaa tta ttc att      439
 Gly Ile Leu Ile Thr Leu Met Thr Phe Ser Ile Ile Glu Leu Phe Ile
     115                 120                 125

 tct ctg cct ttc tca att ttg ggg tgc cac tca gag gat tgt gat tgt      487
 Ser Leu Pro Phe Ser Ile Leu Gly Cys His Ser Glu Asp Cys Asp Cys
 130                 135                 140                 145

 gaa caa tgt tgt tga ctagcactgt gagaataaag atgtgttaaa ataaaaaaaa      542
 Glu Gln Cys Cys 






      <210> 274
      <211> 1074
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1074)

      <400> 274
  atg aat tgg gta aat aag agt gtc cca cag gag ttc att ctg tta gtt      48
  Met Asn Trp Val Asn Lys Ser Val Pro Gln Glu Phe Ile Leu Leu Val
    1               5                  10                  15

 ttc tca gat caa cca tgg cta gag att cca ccc ttt gtg atg ttt ctg       96
 Phe Ser Asp Gln Pro Trp Leu Glu Ile Pro Pro Phe Val Met Phe Leu
              20                  25                  30

 ttt tcc tat atc ttg aca atc ttt ggc aat ctg aca ata att ctt gtg      144
 Phe Ser Tyr Ile Leu Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val
          35                  40                  45

 tca cat gtg gat ttc aaa ctc cac acc cct atg tac ttt ttt ctt agc      192
 Ser His Val Asp Phe Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser
      50                  55                  60

 aat ctc tca ctc ctg gac ctt tgc tat acc aca agt aca gtt cca caa      240
 Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln
  65                  70                  75                  80

 atg ctg gta aac ata tgc aac acc agg aaa gta atc agt tat ggt ggc      288
 Met Leu Val Asn Ile Cys Asn Thr Arg Lys Val Ile Ser Tyr Gly Gly
                  85                  90                  95

 tgt gtg gcc cag ctt ttc att ttc ctg gcc ttg ggt tcc aca gaa tgt      336
 Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ser Thr Glu Cys
             100                 105                 110

 ctt ctc ctg gcc gtc atg tgc ttt gat agg ttt gta gct att tgt cgg      384
 Leu Leu Leu Ala Val Met Cys Phe Asp Arg Phe Val Ala Ile Cys Arg
         115                 120                 125

 cct ctc cat tac tca att atc atg cac cag agg ctc tgc ttc cag ttg      432
 Pro Leu His Tyr Ser Ile Ile Met His Gln Arg Leu Cys Phe Gln Leu
     130                 135                 140

 gca gct gca tcc tgg att agt ggc ttt agc aat tca gta tta cag tcc      480
 Ala Ala Ala Ser Trp Ile Ser Gly Phe Ser Asn Ser Val Leu Gln Ser
 145                 150                 155                 160

 acc tgg aca ctt aag atg cca ctg tgt ggt cac aaa gaa gtg gat cac      528
 Thr Trp Thr Leu Lys Met Pro Leu Cys Gly His Lys Glu Val Asp His
                 165                 170                 175

 ttc ttc tgt gaa gtc cct gct ctg ctc aag ttg tcc tgt gtt gac aca      576
 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Asp Thr
             180                 185                 190

 aca gca aat gag gct gaa cta ttc ttc atc agt gtg cta ttc ctt cta      624
 Thr Ala Asn Glu Ala Glu Leu Phe Phe Ile Ser Val Leu Phe Leu Leu
         195                 200                 205

 ata ccc gtg aca ctc atc ctt ata tcg tat gct ttt att gtc caa gca      672
 Ile Pro Val Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Gln Ala
     210                 215                 220

 gtg ttg aga atc cag tct gct gaa ggt caa cga aag gca ttt ggg aca      720
 Val Leu Arg Ile Gln Ser Ala Glu Gly Gln Arg Lys Ala Phe Gly Thr
 225                 230                 235                 240

 tgt ggc tcc cat cta att gtg gtg tca ctt ttt tat ggt aca gct atc      768
 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ile
                 245                 250                 255

 tcc atg tac ctg caa cca cct tca ccc agc tcc aaa gac cgg gga aag      816
 Ser Met Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Arg Gly Lys
             260                 265                 270

 atg gtt tct ctc ttc tgt gga atc att gca ccc atg ctg aat ccc ctt      864
 Met Val Ser Leu Phe Cys Gly Ile Ile Ala Pro Met Leu Asn Pro Leu
         275                 280                 285

 ata tat aca ctt agg aac aaa gag gta aag gaa gcc ttt aaa agg ttg      912
 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Lys Arg Leu
     290                 295                 300

 gtt gca aag agt ctt ctt aat caa gaa ata aga aat atg caa atg ata      960
 Val Ala Lys Ser Leu Leu Asn Gln Glu Ile Arg Asn Met Gln Met Ile
 305                 310                 315                 320

 agc ttt gct aaa gac aca gtg ctt act tac ctt act aac ttc tcc gca     1008
 Ser Phe Ala Lys Asp Thr Val Leu Thr Tyr Leu Thr Asn Phe Ser Ala
                 325                 330                 335

 agt tgt cct att ttt gtc att act ata gaa aac tat tgt aat ctc cct     1056
 Ser Cys Pro Ile Phe Val Ile Thr Ile Glu Asn Tyr Cys Asn Leu Pro
             340                 345                 350

 caa aga aaa ttt cct tga                                             1074
 Gln Arg Lys Phe Pro 
         355





      <210> 275
      <211> 3321
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3267)

      <400> 275
  atg gag att aaa gac cag gga gcc caa atg gag ccg ctg ctg cct acg      48
  Met Glu Ile Lys Asp Gln Gly Ala Gln Met Glu Pro Leu Leu Pro Thr
    1               5                  10                  15

 aga aat gat gaa gaa gca gtt gtg gat aga ggt gga act cgt tct att       96
 Arg Asn Asp Glu Glu Ala Val Val Asp Arg Gly Gly Thr Arg Ser Ile
              20                  25                  30

 ctc aaa aca cac ttt gag aaa gaa gat tta gaa ggt cat cga aca cta      144
 Leu Lys Thr His Phe Glu Lys Glu Asp Leu Glu Gly His Arg Thr Leu
          35                  40                  45

 ttt att gga gta cat gtg ccc ttg gga gga aga aaa agc cat cga cgt      192
 Phe Ile Gly Val His Val Pro Leu Gly Gly Arg Lys Ser His Arg Arg
      50                  55                  60

 cac agg cat cgt ggt cat aaa cac aga aag aga gac aga gaa aga gat      240
 His Arg His Arg Gly His Lys His Arg Lys Arg Asp Arg Glu Arg Asp
  65                  70                  75                  80

 tca gga tta gag gat gga agg gag tca cct tct ttt gac acc cca tca      288
 Ser Gly Leu Glu Asp Gly Arg Glu Ser Pro Ser Phe Asp Thr Pro Ser
                  85                  90                  95

 cag agg gta cag ttt att ctt gga acc gag gat gat gac gag gaa cac      336
 Gln Arg Val Gln Phe Ile Leu Gly Thr Glu Asp Asp Asp Glu Glu His
             100                 105                 110

 att cct cat gac ctt ttc aca gaa ctg gat gag att tgt tgg cgt gaa      384
 Ile Pro His Asp Leu Phe Thr Glu Leu Asp Glu Ile Cys Trp Arg Glu
         115                 120                 125

 ggt gag gac gct gag tgg cga gaa aca gcc agg tgg ttg aag ttt gaa      432
 Gly Glu Asp Ala Glu Trp Arg Glu Thr Ala Arg Trp Leu Lys Phe Glu
     130                 135                 140

 gaa gat gtg gaa gat gga gga gaa agg tgg agc aag cct tat gtg gct      480
 Glu Asp Val Glu Asp Gly Gly Glu Arg Trp Ser Lys Pro Tyr Val Ala
 145                 150                 155                 160

 act ctt tca ttg cac agc ttg ttt gaa ttg aga agt tgt att ctg aat      528
 Thr Leu Ser Leu His Ser Leu Phe Glu Leu Arg Ser Cys Ile Leu Asn
                 165                 170                 175

 gga act gtg ttg ctg gac atg cat gcc aac act tta gaa gaa att gca      576
 Gly Thr Val Leu Leu Asp Met His Ala Asn Thr Leu Glu Glu Ile Ala
             180                 185                 190

 gat atg gtt ctt gac caa caa gtg agc tca ggt cag ctg aat gaa gat      624
 Asp Met Val Leu Asp Gln Gln Val Ser Ser Gly Gln Leu Asn Glu Asp
         195                 200                 205

 gta cgc cat agg gtc cat gag gca ttg atg aaa cag cat cat cat cag      672
 Val Arg His Arg Val His Glu Ala Leu Met Lys Gln His His His Gln
     210                 215                 220

 agt cag aaa aaa ctc acc aac agg att ccc att gtt cgt tcc ttt gct      720
 Ser Gln Lys Lys Leu Thr Asn Arg Ile Pro Ile Val Arg Ser Phe Ala
 225                 230                 235                 240

 gat att ggc aag aaa cag tca gaa cca aat tcc atg gac aaa aat gca      768
 Asp Ile Gly Lys Lys Gln Ser Glu Pro Asn Ser Met Asp Lys Asn Ala
                 245                 250                 255

 ggt cag gtt gtt tct cct cag tct gct cca gcc tgt gtt gaa aat aaa      816
 Gly Gln Val Val Ser Pro Gln Ser Ala Pro Ala Cys Val Glu Asn Lys
             260                 265                 270

 aat gat gtt agc aga gaa aac agc act gtt gac ttt agc aag gtt gat      864
 Asn Asp Val Ser Arg Glu Asn Ser Thr Val Asp Phe Ser Lys Val Asp
         275                 280                 285

 ctg cat ttt atg aaa aag att cct cca ggt gct gaa gca tcg aac atc      912
 Leu His Phe Met Lys Lys Ile Pro Pro Gly Ala Glu Ala Ser Asn Ile
     290                 295                 300

 tta gtg gga gaa ctg gag ttc ttg gat cga aca gta gtt gcg ttt gtc      960
 Leu Val Gly Glu Leu Glu Phe Leu Asp Arg Thr Val Val Ala Phe Val
 305                 310                 315                 320

 agg ttg tct cca gct gta ttg ctt caa gga ctg gct gaa gtc cca atc     1008
 Arg Leu Ser Pro Ala Val Leu Leu Gln Gly Leu Ala Glu Val Pro Ile
                 325                 330                 335

 cca acc aga ttt ttg ttc att ctt ctg gga ccc ctg gga aag ggt caa     1056
 Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Leu Gly Lys Gly Gln
             340                 345                 350

 cag tac cat gag att ggc aga tca att gca acc cta atg aca gat gag     1104
 Gln Tyr His Glu Ile Gly Arg Ser Ile Ala Thr Leu Met Thr Asp Glu
         355                 360                 365

 gta ttt cat gat gtt gcc tat aaa gct aaa gat cgt aat gac ttg gta     1152
 Val Phe His Asp Val Ala Tyr Lys Ala Lys Asp Arg Asn Asp Leu Val
     370                 375                 380

 tca gga att gat gag ttt ctg gat cag gtt act gtt ctc cct cct gga     1200
 Ser Gly Ile Asp Glu Phe Leu Asp Gln Val Thr Val Leu Pro Pro Gly
 385                 390                 395                 400

 gaa tgg gat cca agc att cga ata gag cct ccc aaa aat gtt cct tcc     1248
 Glu Trp Asp Pro Ser Ile Arg Ile Glu Pro Pro Lys Asn Val Pro Ser
                 405                 410                 415

 cag gag aag agg aag att cct gct gta cca aat gga aca gca gct cat     1296
 Gln Glu Lys Arg Lys Ile Pro Ala Val Pro Asn Gly Thr Ala Ala His
             420                 425                 430

 ggg gaa gca gag ccc cac gga gga cat agt gga cct gaa ctc cag cga     1344
 Gly Glu Ala Glu Pro His Gly Gly His Ser Gly Pro Glu Leu Gln Arg
         435                 440                 445

 act gga agg att ttt ggg gga ctt att tta gat atc aaa aga aaa gct     1392
 Thr Gly Arg Ile Phe Gly Gly Leu Ile Leu Asp Ile Lys Arg Lys Ala
     450                 455                 460

 cca tac ttc tgg agt gac ttc aga gat gct ttc agc ctg cag tgc tta     1440
 Pro Tyr Phe Trp Ser Asp Phe Arg Asp Ala Phe Ser Leu Gln Cys Leu
 465                 470                 475                 480

 gca tct ttt cta ttt ctc tac tgc gcg tgt atg tct cct gtc atc acg     1488
 Ala Ser Phe Leu Phe Leu Tyr Cys Ala Cys Met Ser Pro Val Ile Thr
                 485                 490                 495

 ttt gga gga ctg ctg gga gaa gca act gaa ggg cgt ata agt gca att     1536
 Phe Gly Gly Leu Leu Gly Glu Ala Thr Glu Gly Arg Ile Ser Ala Ile
             500                 505                 510

 gaa tct ctc ttt gga gca tcc atg acc ggg ata gcc tat tct ctc ttt     1584
 Glu Ser Leu Phe Gly Ala Ser Met Thr Gly Ile Ala Tyr Ser Leu Phe
         515                 520                 525

 ggt gga cag cct ctt acc ata tta ggc agt aca gga cca gtt ttg gtg     1632
 Gly Gly Gln Pro Leu Thr Ile Leu Gly Ser Thr Gly Pro Val Leu Val
     530                 535                 540

 ttt gaa aag att ttg ttt aaa ttt tgc aaa gaa tat ggg ctg tca tac     1680
 Phe Glu Lys Ile Leu Phe Lys Phe Cys Lys Glu Tyr Gly Leu Ser Tyr
 545                 550                 555                 560

 cta tct tta aga gct agc att gga ctt tgg act gca act cta tgt atc     1728
 Leu Ser Leu Arg Ala Ser Ile Gly Leu Trp Thr Ala Thr Leu Cys Ile
                 565                 570                 575

 ata ctt gtg gcc aca gat gct agt tcc ctt gtc tgc tac atc act cgg     1776
 Ile Leu Val Ala Thr Asp Ala Ser Ser Leu Val Cys Tyr Ile Thr Arg
             580                 585                 590

 ttt act gaa gaa gct ttt gct tcc ctg att tgc atc att ttc att tat     1824
 Phe Thr Glu Glu Ala Phe Ala Ser Leu Ile Cys Ile Ile Phe Ile Tyr
         595                 600                 605

 gag gcc ctg gag aag ttg ttt gaa ctc agt gaa gca tat cca atc aac     1872
 Glu Ala Leu Glu Lys Leu Phe Glu Leu Ser Glu Ala Tyr Pro Ile Asn
     610                 615                 620

 atg cat aat gat ctg gaa ctg ctg aca caa tac tcg tgt aac tgt gtg     1920
 Met His Asn Asp Leu Glu Leu Leu Thr Gln Tyr Ser Cys Asn Cys Val
 625                 630                 635                 640

 gaa ccg cat aat ccc agc aat ggc aca ttg aag gaa tgg agg gaa tcc     1968
 Glu Pro His Asn Pro Ser Asn Gly Thr Leu Lys Glu Trp Arg Glu Ser
                 645                 650                 655

 aat att tct gcc tct gac ata att tgg gag aac cta act gtg tca gaa     2016
 Asn Ile Ser Ala Ser Asp Ile Ile Trp Glu Asn Leu Thr Val Ser Glu
             660                 665                 670

 tgc aaa tca ttg cat gga gag tat gtt gga cgg gcc tgt ggc cat gat     2064
 Cys Lys Ser Leu His Gly Glu Tyr Val Gly Arg Ala Cys Gly His Asp
         675                 680                 685

 cac cca tat gtt cca gat gtt cta ttt tgg tct gtg atc ctg ttc ttt     2112
 His Pro Tyr Val Pro Asp Val Leu Phe Trp Ser Val Ile Leu Phe Phe
     690                 695                 700

 tcc aca gtt act ctg tca gcc acc ctg aag cag ttc aag act agc aga     2160
 Ser Thr Val Thr Leu Ser Ala Thr Leu Lys Gln Phe Lys Thr Ser Arg
 705                 710                 715                 720

 tat ttt cca acc aag gtt cga tcc ata gtg agt gac ttt gct gtc ttt     2208
 Tyr Phe Pro Thr Lys Val Arg Ser Ile Val Ser Asp Phe Ala Val Phe
                 725                 730                 735

 ctt aca att ctg tgt atg gtt tta att gac tat gcc att ggg atc cca     2256
 Leu Thr Ile Leu Cys Met Val Leu Ile Asp Tyr Ala Ile Gly Ile Pro
             740                 745                 750

 tct cca aaa cta caa gta cca agt gtt ttc aag ccc act aga gat gat     2304
 Ser Pro Lys Leu Gln Val Pro Ser Val Phe Lys Pro Thr Arg Asp Asp
         755                 760                 765

 cgt ggc tgg ttt gtt acg cct tta ggt cca aac cca tgg tgg aca gta     2352
 Arg Gly Trp Phe Val Thr Pro Leu Gly Pro Asn Pro Trp Trp Thr Val
     770                 775                 780

 ata gct gct ata att cca gct ctg ctt tgt act att cta att ttt atg     2400
 Ile Ala Ala Ile Ile Pro Ala Leu Leu Cys Thr Ile Leu Ile Phe Met
 785                 790                 795                 800

 gac caa cag att aca gct gtc atc atc aac agg aaa gag cat aag cta     2448
 Asp Gln Gln Ile Thr Ala Val Ile Ile Asn Arg Lys Glu His Lys Leu
                 805                 810                 815

 aag aaa ggt tgt ggg tac cat ctg gac cta tta atg gtg gct gtc atg     2496
 Lys Lys Gly Cys Gly Tyr His Leu Asp Leu Leu Met Val Ala Val Met
             820                 825                 830

 ctc ggt gta tgc tcc atc atg ggc ctg cca tgg ttt gtg gct gcc aca     2544
 Leu Gly Val Cys Ser Ile Met Gly Leu Pro Trp Phe Val Ala Ala Thr
         835                 840                 845

 gtc ctc tcc atc act cat gtc aat agc cta aaa ctg gaa tca gaa tgc     2592
 Val Leu Ser Ile Thr His Val Asn Ser Leu Lys Leu Glu Ser Glu Cys
     850                 855                 860

 tca gct cca gga gaa caa ccc aaa ttt ctc ggc att cgg gag caa agg     2640
 Ser Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Ile Arg Glu Gln Arg
 865                 870                 875                 880

 gtt act ggg ctt atg att ttt att ctt atg ggt tca tca gtc ttt atg     2688
 Val Thr Gly Leu Met Ile Phe Ile Leu Met Gly Ser Ser Val Phe Met
                 885                 890                 895

 acc agt att ctg aag ttt att ccc atg cca gtg cta tat gga gtg ttt     2736
 Thr Ser Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe
             900                 905                 910

 ctt tat atg ggt gct tca tct cta aag gga att cag ttc ttt gat agg     2784
 Leu Tyr Met Gly Ala Ser Ser Leu Lys Gly Ile Gln Phe Phe Asp Arg
         915                 920                 925

 ata aag ctc ttc tgg atg ccg gca aaa cat caa cca gat ttt ata tac     2832
 Ile Lys Leu Phe Trp Met Pro Ala Lys His Gln Pro Asp Phe Ile Tyr
     930                 935                 940

 cta agg cac gta ccg ctt cga aaa gtg cat ctc ttc aca att att cag     2880
 Leu Arg His Val Pro Leu Arg Lys Val His Leu Phe Thr Ile Ile Gln
 945                 950                 955                 960

 atg agt tgc ctt ggc ctt ttg tgg ata ata aaa gtt tca aga gct gct     2928
 Met Ser Cys Leu Gly Leu Leu Trp Ile Ile Lys Val Ser Arg Ala Ala
                 965                 970                 975

 att gtc ttt ccc atg atg gtg tta gcc ctg gta ttt gta aga aag ttg     2976
 Ile Val Phe Pro Met Met Val Leu Ala Leu Val Phe Val Arg Lys Leu
             980                 985                 990

 atg gac ttg ttg ttc acg aag cgg gaa ctc agc tgg ttg gat gat ttg     3024
 Met Asp Leu Leu Phe Thr Lys Arg Glu Leu Ser Trp Leu Asp Asp Leu
         995                1000                1005

 atg ccc gag agt aag aaa aag aaa ctg gaa tat gct gaa aaa gaa gaa     3072
 Met Pro Glu Ser Lys Lys Lys Lys Leu Glu Tyr Ala Glu Lys Glu Glu
    1010                1015                1020

 gaa caa tgt gtg cta cct atg gaa gat gag ggc aca gta caa ctc cca     3120
 Glu Gln Cys Val Leu Pro Met Glu Asp Glu Gly Thr Val Gln Leu Pro
1025                1030                1035                1040

 ttg gaa ggg cac tat aga gat gat cca tct gtg atc aat ata tct gat     3168
 Leu Glu Gly His Tyr Arg Asp Asp Pro Ser Val Ile Asn Ile Ser Asp
                1045                1050                1055

 gaa atg tca aag act gcc ttg tgg agg aac ctt ctg att act gcc gat     3216
 Glu Met Ser Lys Thr Ala Leu Trp Arg Asn Leu Leu Ile Thr Ala Asp
            1060                1065                1070

 aac tca aaa gat aag gag tca agc ttt cct tcc aaa agc tcc cct tcc     3264
 Asn Ser Lys Asp Lys Glu Ser Ser Phe Pro Ser Lys Ser Ser Pro Ser
        1075                1080                1085

 taa tcac tctagaagct gattccccaa agcattgaaa gccgaaaaga gaagaaagct     3321
 






      <210> 276
      <211> 3170
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(1401)

      <400> 276
 atgccgggtg actcctcccc ggggactctc ccactctggg acgcgtcact ctccccaccc     60

 ctgggtccgg accccggcgg cttctcgcgc gcgagccacg cgggggacaa gtcgcggcca    120

 cctgctccgg agctggggag cccgggcgcc gtccgcccgc gcgtcggttc gtgtgccccg    180

 ggcccc   atg gag ctg cgg gtc agc aac acc agc tgc gag aac ggt tcc     228
          Met Glu Leu Arg Val Ser Asn Thr Ser Cys Glu Asn Gly Ser
            1               5                  10

 ctg ctc cac ctc tac tgc tcc tcc caa gaa gtc ctg tgc cag att gtc      276
 Leu Leu His Leu Tyr Cys Ser Ser Gln Glu Val Leu Cys Gln Ile Val
  15                  20                  25                  30

 aat gac ctc agc cct gag gtg ccc agc aat gcc acc ttt cac agc tgg      324
 Asn Asp Leu Ser Pro Glu Val Pro Ser Asn Ala Thr Phe His Ser Trp
                  35                  40                  45

 cag gaa aga atc agg cag aac tat ggc ttc tac atc ggc ctg ggc ctg      372
 Gln Glu Arg Ile Arg Gln Asn Tyr Gly Phe Tyr Ile Gly Leu Gly Leu
              50                  55                  60

 gca ttc ctg tct agc ttc ctc atc ggc agc agc gtc atc ctc aag aag      420
 Ala Phe Leu Ser Ser Phe Leu Ile Gly Ser Ser Val Ile Leu Lys Lys
          65                  70                  75

 aaa ggc ctc ttg cga ctc gtg gcc acg gga gcc act cga gct gtg gat      468
 Lys Gly Leu Leu Arg Leu Val Ala Thr Gly Ala Thr Arg Ala Val Asp
      80                  85                  90

 gga ggc ttc ggc tac ctg aaa gat gca atg tgg tgg gct gga ttt ctc      516
 Gly Gly Phe Gly Tyr Leu Lys Asp Ala Met Trp Trp Ala Gly Phe Leu
  95                 100                 105                 110

 acc atg gct gct gga gaa gtt gcc aac ttt gga gcc tac gca ttt gca      564
 Thr Met Ala Ala Gly Glu Val Ala Asn Phe Gly Ala Tyr Ala Phe Ala
                 115                 120                 125

 cct gca aca gtc gtc acg cct ctg gga gcg ctg agt gtc ctc ata agt      612
 Pro Ala Thr Val Val Thr Pro Leu Gly Ala Leu Ser Val Leu Ile Ser
             130                 135                 140

 gcc atc ctc tcc tca tat ttc ctg agg gag agt ctg aac ctg ctg ggg      660
 Ala Ile Leu Ser Ser Tyr Phe Leu Arg Glu Ser Leu Asn Leu Leu Gly
         145                 150                 155

 aag ctg ggc tgt gtg atc tgt gtg gcc gga agc aca gtg atg gtg ata      708
 Lys Leu Gly Cys Val Ile Cys Val Ala Gly Ser Thr Val Met Val Ile
     160                 165                 170

 cat gct cct gag gaa gag aag gtc act acc atc atg gag atg gct tcc      756
 His Ala Pro Glu Glu Glu Lys Val Thr Thr Ile Met Glu Met Ala Ser
 175                 180                 185                 190

 aag gtg aaa gac aca ggg ttc atc gtg ttt gct gtg ctt ctg ctg gtg      804
 Lys Val Lys Asp Thr Gly Phe Ile Val Phe Ala Val Leu Leu Leu Val
                 195                 200                 205

 tca tgc ctc atc ctc atc ttt gtc att gcc cca tgt tac ggg caa agg      852
 Ser Cys Leu Ile Leu Ile Phe Val Ile Ala Pro Cys Tyr Gly Gln Arg
             210                 215                 220

 aat atc ctc atc tac atc atc atc tgc tct gtg atc ggg gcc ttc tct      900
 Asn Ile Leu Ile Tyr Ile Ile Ile Cys Ser Val Ile Gly Ala Phe Ser
         225                 230                 235

 gtg gct gct gtc aag ggg ctg ggc atc acc atc aag aac ttc ttc cag      948
 Val Ala Ala Val Lys Gly Leu Gly Ile Thr Ile Lys Asn Phe Phe Gln
     240                 245                 250

 ggg ctg cca gtt gtc cgg cac ccg ctc ccc tac atc ctg tcc ctc atc      996
 Gly Leu Pro Val Val Arg His Pro Leu Pro Tyr Ile Leu Ser Leu Ile
 255                 260                 265                 270

 ctg gca ctg acc ctc agc act cag gtc aac ttc ctc aac aga gca ccg     1044
 Leu Ala Leu Thr Leu Ser Thr Gln Val Asn Phe Leu Asn Arg Ala Pro
                 275                 280                 285

 gac att ttc aac act tcc ctg gtg ttc ccc atc tac tac gtg ttc ttc     1092
 Asp Ile Phe Asn Thr Ser Leu Val Phe Pro Ile Tyr Tyr Val Phe Phe
             290                 295                 300

 acc acg gtg gtc gtt acc tcg tcc atc atc ctc ttc aag gag tgg tac     1140
 Thr Thr Val Val Val Thr Ser Ser Ile Ile Leu Phe Lys Glu Trp Tyr
         305                 310                 315

 agc atg tct gct gtg gac att gca ggc acc ctc tcg ggc ttt gtc acc     1188
 Ser Met Ser Ala Val Asp Ile Ala Gly Thr Leu Ser Gly Phe Val Thr
     320                 325                 330

 atc atc ttg ggc gtg ttc atg ctg cat gct ttc aaa gac ctg gac atc     1236
 Ile Ile Leu Gly Val Phe Met Leu His Ala Phe Lys Asp Leu Asp Ile
 335                 340                 345                 350

 agc tgc gcc agc ttg ccc cac atg cac aaa aac cca ccc cct tct ccc     1284
 Ser Cys Ala Ser Leu Pro His Met His Lys Asn Pro Pro Pro Ser Pro
                 355                 360                 365

 gcc ccg gaa ccc act gtt att aga ctg gaa gac aag aac gtc ctt gtg     1332
 Ala Pro Glu Pro Thr Val Ile Arg Leu Glu Asp Lys Asn Val Leu Val
             370                 375                 380

 gac aat ata gaa ctt gcc agc acc tca tca cca gaa gag aaa ccc aaa     1380
 Asp Asn Ile Glu Leu Ala Ser Thr Ser Ser Pro Glu Glu Lys Pro Lys
         385                 390                 395

 gta ttt ata atc cat tcc tga ag cttggaatat gtgagtgaga ggatgagtcc     1433
 Val Phe Ile Ile His Ser 
     400

 gatggtacag cctgccctcc caatttcaaa accacctggt tattttccag tgcaactgtt   1493

 accaatgggc tctcttttct tgagaagttc atttatacct catcactgtt tccaggagaa   1553

 aaatctttac ccaaatagca atggtggcag aacttcctgg aaacagattc agtgaccaaa   1613

 tacccaagtt tacatcagtg cctgcaggtt ccctggacct tccttctcat tcattctttc   1673

 ggtgccatct ctatgccgtt gggaagaaga tggagtctga cccactgaat gtagcacagt   1733

 ccaaggactt ctctaagata ttggtcattg gaagttcctt cacaccaatt ctcctcctga   1793

 gacggaatct ccgttgttgt tgttgttgtt gttttctagc ccaaggatga catagagctg   1853

 gctcccagag gcccacagag caattggcca tgcctcccta tccagagctg acagggacac   1913

 aaccagtgta aaatatcctg ttgcctttgt cacttcctct ttggaggcag aagcaagacc   1973

 tcagctgacc ttcttactgt gaaagccact tgatgtctca gggaaaaatt tcaaccagct   2033

 cattccccga gcactccagc ctggcagtca gcacctcggc atccacccag tccatcccac   2093

 catcacccct tccccctcta cttacatcct aaggagtcgg tcactgagac ataaaggcag   2153

 taatcgcaga actggaaaca aaacaataat agagccacag ccaaactctg gtggccaaac   2213

 ccagtgttgc attttgtctt actctgaaag aagaacagca aattcactgc ttcaaagtgg   2273

 cctggctgcc aagctagaat ttggcagaac gcactttact attcctcaag gagtcaacca   2333

 acctatgatc tggggaggtg ggaagaggat gaggagcaaa gttgggattt ggcagaaggc   2393

 agtcccaggc tctctggata ctaggggcta acttttgtgt tgactctggt gctcatctgg   2453

 gaacttagga gaaacgagct caggggtaat ttctgggttg cagccttaaa ggcttggaca   2513

 gctgtgaatc tcaatggcca actggaggtg cagacttggc atggggtgca ttctagctgt   2573

 tgaccagatt gctaccgagt cccctcctcc actgatgagc tgcccacact gggaagcagc   2633

 atgccctgac tgttccaaca ccacctgcta tggggagtac ctttggtccc ctcacatttg   2693

 gccagaggca tacaaaaaac cagagcagct ggagagggag ataattacta ttccttccct   2753

 tcctatctcc tttctagcca caagagtgtg ggggttggag aagaaccatt agaaagggaa   2813

 attagtgggc tggtgtatct ggaaagaggg aagacttgat cctcagcccc gaggttggtg   2873

 cagggcctcc cctgtgtgac tctacctgca ctctgtgttt atatcctgtg ccctaagtgg   2933

 gccaagccca ggtaaattcc tgctggcctt ggaactccaa ggtttggctg accagcagac   2993

 tggctccctg actcttcagc ctcaaatccc cagtttttga tgaatgtgga tttctgtctg   3053

 taattaaaag caatgcaaca agttggctct tgagaatggc agtaaactga gggccctaag   3113

 agtgtggtct gcagggtcaa gaataaagat tacagattat atttaaaaaa aaaaaaa      3170


      <210> 277
      <211> 363
      <212> PRT
      <213> Homo sapiens


      <400> 277
 Met Leu Leu Ser Ile Gly Met Leu Met Leu Ser Ala Thr Gln Val Tyr
   1               5                  10                  15    
 Thr Ile Leu Thr Val Gln Leu Phe Ala Phe Leu Asn Leu Leu Pro Val
              20                  25                  30        
 Glu Ala Asp Ile Leu Ala Tyr Asn Phe Glu Asn Ala Ser Gln Thr Phe
          35                  40                  45            
 Asp Asp Leu Pro Ala Arg Phe Gly Tyr Arg Leu Pro Ala Glu Gly Leu
      50                  55                  60                
 Lys Gly Phe Leu Ile Asn Ser Lys Pro Glu Asn Ala Cys Glu Pro Ile
  65                  70                  75                  80
 Val Pro Pro Pro Val Phe Asp Ile Lys Val Leu Asn Ala Gln Arg Ala
                  85                  90                  95    
 Gly Tyr Lys Ala Ala Ile Val His Asn Val Asp Ser Asp Asp Leu Ile
             100                 105                 110        
 Ser Met Gly Ser Asn Asp Ile Glu Val Leu Lys Lys Ile Asp Ile Pro
         115                 120                 125            
 Ser Val Phe Ile Gly Glu Ser Ser Ala Asn Ser Leu Lys Asp Glu Phe
     130                 135                 140                
 Thr Tyr Glu Lys Gly Gly His Leu Ile Leu Val Pro Glu Phe Ser Leu
 145                 150                 155                 160
 Pro Leu Glu Tyr Tyr Leu Ile Pro Phe Leu Ile Ile Val Gly Ile Cys
                 165                 170                 175    
 Leu Ile Leu Ile Val Ile Phe Met Ile Thr Lys Phe Val Gln Asp Arg
             180                 185                 190        
 His Arg Ala Arg Arg Asn Arg Leu Arg Lys Asp Gln Leu Lys Lys Leu
         195                 200                 205            
 Pro Val His Lys Phe Lys Lys Gly Asp Glu Tyr Asp Val Cys Ala Ile
     210                 215                 220                
 Cys Leu Asp Glu Tyr Glu Asp Gly Asp Lys Leu Arg Ile Leu Pro Cys
 225                 230                 235                 240
 Ser His Ala Tyr His Cys Lys Cys Val Asp Pro Trp Leu Thr Lys Thr
                 245                 250                 255    
 Lys Lys Thr Cys Pro Val Cys Lys Gln Lys Val Val Pro Ser Gln Gly
             260                 265                 270        
 Asp Ser Asp Ser Asp Thr Asp Ser Ser Gln Glu Glu Asn Glu Val Thr
         275                 280                 285            
 Glu His Thr Pro Leu Leu Arg Pro Leu Ala Ser Val Ser Ala Gln Ser
     290                 295                 300                
 Phe Gly Ala Leu Ser Glu Ser Arg Ser His Gln Asn Met Thr Glu Ser
 305                 310                 315                 320
 Ser Asp Tyr Glu Glu Asp Asp Asn Glu Asp Thr Asp Ser Ser Asp Ala
                 325                 330                 335    
 Glu Asn Glu Ile Asn Glu His Asp Val Val Val Gln Leu Gln Pro Asn
             340                 345                 350        
 Gly Glu Arg Asp Tyr Asn Ile Ala Asn Thr Val
         355                 360            



      <210> 278
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 278
 Met Leu Leu Ser Ile Gly Met Leu Met Leu Ser Ala Thr Gln Val Tyr
   1               5                  10                  15    
 Thr Ile Leu Thr Val Gln Leu Phe Ala Phe Leu Asn Leu Leu Pro Val
              20                  25                  30        
 Glu Ala Asp Ile Leu Ala Tyr Asn Phe Glu Asn Ala Ser Gln Thr Phe
          35                  40                  45            
 Asp Asp Leu Pro Ala Arg Phe Gly Tyr Arg Leu Pro Ala Glu Gly Leu
      50                  55                  60                
 Lys Val Leu Asn Ala Gln Arg Ala Gly Tyr Lys Ala Ala Ile Val His
  65                  70                  75                  80
 Asn Val Asp Ser Asp Asp Leu Ile Ser Met Gly Ser Asn Asp Ile Glu
                  85                  90                  95    
 Val Leu Lys Lys Ile Asp Ile Pro Ser Val Phe Ile Gly Glu Ser Ser
             100                 105                 110        
 Ala Asn Ser Leu Lys Asp Glu Phe Thr Tyr Glu Lys Gly Gly His Leu
         115                 120                 125            
 Ile Leu Val Pro Glu Phe Ser Leu Pro Leu Glu Tyr Tyr Leu Ile Pro
     130                 135                 140                
 Phe Leu Ile Ile Val Gly Ile Cys Leu Ile Leu Ile Val Ile Phe Met
 145                 150                 155                 160
 Ile Thr Lys Phe Val Gln Asp Arg His Arg Ala Arg Arg Asn Arg Leu
                 165                 170                 175    
 Arg Lys Asp Gln Leu Lys Lys Leu Pro Val His Lys Phe Lys Lys Gly
             180                 185                 190        
 Asp Glu Tyr Asp Val Cys Ala Ile Cys Leu Asp Glu Tyr Glu Asp Gly
         195                 200                 205            
 Asp Lys Leu Arg Ile Leu Pro Cys Ser His Ala Tyr His Cys Lys Cys
     210                 215                 220                
 Val Asp Pro Trp Leu Thr Lys Thr Lys Lys Thr Cys Pro Val Cys Lys
 225                 230                 235                 240
 Gln Lys Val Val Pro Ser Gln Gly Asp Ser Asp Ser Asp Thr Asp Ser
                 245                 250                 255    
 Ser Gln Glu Glu Asn Glu Val Thr Glu His Thr Pro Leu Leu Arg Pro
             260                 265                 270        
 Leu Ala Ser Val Ser Ala Gln Ser Phe Gly Ala Leu Ser Glu Ser Arg
         275                 280                 285            
 Ser His Gln Asn Met Thr Glu Ser Ser Asp Tyr Glu Glu Asp Asp Asn
     290                 295                 300                
 Glu Asp Thr Asp Ser Ser Asp Ala Glu Asn Glu Ile Asn Glu His Asp
 305                 310                 315                 320
 Val Val Val Gln Leu Gln Pro Asn Gly Glu Arg Asp Tyr Asn Ile Ala
                 325                 330                 335    
 Asn Thr Val
            



      <210> 279
      <211> 352
      <212> PRT
      <213> Homo sapiens


      <400> 279
 Met Leu Leu Ser Ile Gly Met Leu Met Leu Ser Ala Thr Gln Val Tyr
   1               5                  10                  15    
 Thr Ile Leu Thr Val Gln Leu Phe Ala Phe Leu Asn Leu Leu Pro Val
              20                  25                  30        
 Glu Ala Asp Ile Leu Ala Tyr Asn Phe Glu Asn Ala Ser Gln Thr Phe
          35                  40                  45            
 Asp Asp Leu Pro Ala Arg Phe Gly Tyr Arg Leu Pro Ala Glu Gly Leu
      50                  55                  60                
 Lys Gly Phe Leu Ile Asn Ser Lys Pro Glu Asn Ala Cys Glu Pro Ile
  65                  70                  75                  80
 Val Pro Pro Pro Val Lys Asp Asn Ser Ser Gly Thr Phe Ile Val Leu
                  85                  90                  95    
 Ile Arg Arg Leu Asp Cys Asn Phe Asp Ile Lys Val Leu Asn Ala Gln
             100                 105                 110        
 Arg Ala Gly Tyr Lys Ala Ala Ile Val His Asn Val Asp Ser Asp Asp
         115                 120                 125            
 Leu Ile Ser Met Gly Ser Asn Asp Ile Glu Val Leu Lys Lys Ile Asp
     130                 135                 140                
 Ile Pro Ser Val Phe Ile Gly Glu Ser Ser Ala Asn Ser Leu Lys Asp
 145                 150                 155                 160
 Glu Phe Thr Tyr Glu Lys Gly Gly His Leu Ile Leu Val Pro Glu Phe
                 165                 170                 175    
 Ser Leu Pro Leu Glu Tyr Tyr Leu Ile Pro Phe Leu Ile Ile Val Gly
             180                 185                 190        
 Ile Cys Leu Ile Leu Ile Val Ile Phe Met Ile Thr Lys Phe Val Gln
         195                 200                 205            
 Asp Arg His Arg Ala Arg Arg Asn Arg Leu Arg Lys Asp Gln Leu Lys
     210                 215                 220                
 Lys Leu Pro Val His Lys Phe Lys Lys Gly Asp Glu Tyr Asp Val Cys
 225                 230                 235                 240
 Ala Ile Cys Leu Asp Glu Tyr Glu Asp Gly Asp Lys Leu Arg Ile Leu
                 245                 250                 255    
 Pro Cys Ser His Gly Asp Ser Asp Ser Asp Thr Asp Ser Ser Gln Glu
             260                 265                 270        
 Glu Asn Glu Val Thr Glu His Thr Pro Leu Leu Arg Pro Leu Ala Ser
         275                 280                 285            
 Val Ser Ala Gln Ser Phe Gly Ala Leu Ser Glu Ser Arg Ser His Gln
     290                 295                 300                
 Asn Met Thr Glu Ser Ser Asp Tyr Glu Glu Asp Asp Asn Glu Asp Thr
 305                 310                 315                 320
 Asp Ser Ser Asp Ala Glu Asn Glu Ile Asn Glu His Asp Val Val Val
                 325                 330                 335    
 Gln Leu Gln Pro Asn Gly Glu Arg Asp Tyr Asn Ile Ala Asn Thr Val
             340                 345                 350        





      <210> 280
      <211> 266
      <212> PRT
      <213> Homo sapiens


      <400> 280
 Met Leu Leu Thr Leu Ala Gly Gly Ala Leu Phe Phe Pro Gly Leu Phe
   1               5                  10                  15    
 Ala Leu Cys Thr Trp Ala Leu Arg Arg Ser Gln Pro Gly Trp Ser Arg
              20                  25                  30        
 Thr Asp Cys Val Met Ile Ser Thr Arg Leu Val Ser Ser Val His Ala
          35                  40                  45            
 Val Leu Ala Thr Gly Ser Gly Ile Val Ile Ile Arg Ser Cys Asp Asp
      50                  55                  60                
 Val Ile Thr Gly Arg His Trp Leu Ala Arg Glu Tyr Val Trp Phe Leu
  65                  70                  75                  80
 Ile Pro Tyr Met Ile Tyr Asp Ser Tyr Ala Met Tyr Leu Cys Glu Trp
                  85                  90                  95    
 Cys Arg Thr Arg Asp Gln Asn Arg Ala Pro Ser Leu Thr Leu Arg Asn
             100                 105                 110        
 Phe Leu Ser Arg Asn Arg Leu Met Ile Thr His His Ala Val Ile Leu
         115                 120                 125            
 Phe Val Leu Val Pro Val Ala Gln Arg Leu Arg Gly Asp Leu Gly Asp
     130                 135                 140                
 Phe Phe Val Gly Cys Ile Phe Thr Ala Glu Leu Ser Thr Pro Phe Val
 145                 150                 155                 160
 Ser Leu Gly Arg Val Leu Ile Gln Ala Cys Met Asn Glu Met Thr Glu
                 165                 170                 175    
 Ser Leu Lys Gln Gln His Thr Leu Leu Tyr Lys Val Asn Gly Ile Leu
             180                 185                 190        
 Thr Leu Ala Thr Phe Leu Ser Cys Arg Ile Leu Leu Phe Pro Phe Met
         195                 200                 205            
 Tyr Trp Ser Tyr Gly Arg Gln Gln Gly Leu Ser Leu Leu Gln Val Pro
     210                 215                 220                
 Phe Ser Ile Pro Phe Tyr Cys Asn Val Ala Asn Ala Phe Leu Val Ala
 225                 230                 235                 240
 Pro Gln Ile Tyr Trp Phe Cys Leu Leu Cys Arg Lys Ala Val Arg Leu
                 245                 250                 255    
 Phe Asp Thr Pro Gln Ala Lys Lys Asp Gly
             260                 265    



      <210> 281
      <211> 121
      <212> PRT
      <213> Homo sapiens


      <400> 281
 Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu
   1               5                  10                  15    
 Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys
              20                  25                  30        
 Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Leu Leu Leu Met Ser Leu
          35                  40                  45            
 His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp Asn Ile
      50                  55                  60                
 Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Met Gly Val Phe Asp Pro
  65                  70                  75                  80
 Thr Glu Ile His Asn Arg Gly Gln Leu Lys Ser His Met Lys Glu Ala
                  85                  90                  95    
 Met Ile Lys Leu Gly Phe His Leu Leu Cys Phe Phe Met Tyr Leu Tyr
             100                 105                 110        
 Ser Met Ile Leu Ala Leu Ile Asn Asp
         115                 120    



      <210> 282
      <211> 174
      <212> PRT
      <213> Homo sapiens


      <400> 282
 Met Ala Arg Ala Cys Leu Gln Ala Val Lys Tyr Leu Met Phe Ala Phe
   1               5                  10                  15    
 Asn Leu Leu Phe Trp Phe Phe Leu Leu Leu Leu Leu Val Phe Leu Leu
              20                  25                  30        
 Glu Ala Thr Ile Ala Ile Leu Phe Phe Ala Tyr Thr Asp Lys Ile Asp
          35                  40                  45            
 Arg Tyr Ala Gln Gln Asp Leu Lys Lys Gly Leu His Leu Tyr Gly Thr
      50                  55                  60                
 Gln Gly Asn Val Gly Leu Thr Asn Ala Trp Ser Ile Ile Gln Thr Asp
  65                  70                  75                  80
 Phe Arg Cys Cys Gly Val Ser Asn Tyr Thr Asp Trp Phe Glu Val Tyr
                  85                  90                  95    
 Asn Ala Thr Arg Val Pro Asp Ser Cys Cys Leu Glu Phe Ser Glu Ser
             100                 105                 110        
 Cys Gly Leu His Ala Pro Gly Thr Trp Trp Lys Ala Pro Cys Tyr Glu
         115                 120                 125            
 Thr Val Lys Val Trp Leu Gln Glu Asn Leu Leu Ala Val Gly Ile Phe
     130                 135                 140                
 Gly Leu Cys Thr Ala Leu Val Gln Ile Leu Gly Leu Thr Phe Ala Met
 145                 150                 155                 160
 Thr Met Tyr Cys Gln Val Val Lys Ala Asp Thr Tyr Cys Ala
                 165                 170                



      <210> 283
      <211> 413
      <212> PRT
      <213> Homo sapiens


      <400> 283
 Met Arg Gly Lys Leu Leu Pro Leu Ala Gly Leu Tyr Leu Val Gln Gly
   1               5                  10                  15    
 Leu Pro Tyr Gly Leu Gln Ser Gly Leu Leu Pro Val Leu Leu Arg Ala
              20                  25                  30        
 Gly Gly Leu Ser Leu Thr Arg Val Gly Leu Ala Lys Val Leu Tyr Ala
          35                  40                  45            
 Pro Trp Leu Leu Lys Leu Ala Trp Ala Pro Leu Val Asp Ala Gln Gly
      50                  55                  60                
 Ser Ala Arg Ala Trp Val Thr Arg Ser Thr Ala Gly Leu Gly Leu Val
  65                  70                  75                  80
 Cys Gly Leu Leu Ala Gly Leu Pro Pro Pro Gly Ala Gly Gln Ala Gly
                  85                  90                  95    
 Leu Pro Ala Ala Val Ala Gly Leu Leu Leu Leu Leu Asn Leu Gly Ala
             100                 105                 110        
 Ala Met His Gly Cys Gly Pro Gly Arg Ala Trp Pro Val Gln Leu Leu
         115                 120                 125            
 Glu Pro Ala Glu Leu Gly Pro Gly Asn Thr Val Gln Val Val Ala Tyr
     130                 135                 140                
 Lys Leu Gly Ala Ala Leu Ala Gly Gly Ala Leu Leu Ala Leu Leu Pro
 145                 150                 155                 160
 Thr Phe Ser Trp Pro Gln Leu Phe Leu Leu Leu Ala Ala Thr Tyr Trp
                 165                 170                 175    
 Leu Ala Ala Ala Leu Ala Trp Ala Ala Pro Ala Leu Arg Arg Leu Pro
             180                 185                 190        
 Gln Gln Pro Pro Ser Glu Gln Arg Pro His Thr Ala His Leu Leu Arg
         195                 200                 205            
 Asp Val Leu Ala Val Pro Gly Thr Val Trp Thr Ala Gly Phe Val Leu
     210                 215                 220                
 Thr Tyr Lys Leu Gly Glu Gln Gly Ala Ser Ser Leu Phe Pro Leu Leu
 225                 230                 235                 240
 Leu Leu Asp His Gly Val Ser Ala Pro Glu Leu Gly Leu Trp Asn Gly
                 245                 250                 255    
 Val Gly Ala Val Val Cys Ser Ile Ala Gly Ser Ser Leu Gly Gly Thr
             260                 265                 270        
 Leu Leu Ala Lys His Trp Lys Leu Leu Pro Leu Leu Arg Ser Val Leu
         275                 280                 285            
 Arg Phe Arg Leu Gly Gly Leu Ala Cys Gln Thr Ala Leu Val Phe His
     290                 295                 300                
 Leu Asp Thr Leu Gly Ala Ser Met Asp Ala Gly Thr Ile Leu Arg Gly
 305                 310                 315                 320
 Ser Ala Leu Leu Ser Leu Cys Leu Gln His Phe Leu Gly Gly Leu Val
                 325                 330                 335    
 Thr Thr Val Thr Phe Thr Gly Met Met Arg Cys Ser Gln Leu Ala Pro
             340                 345                 350        
 Arg Ala Leu Gln Ala Thr His Tyr Ser Leu Leu Ala Thr Leu Glu Leu
         355                 360                 365            
 Leu Gly Lys Leu Leu Leu Gly Thr Leu Ala Gly Gly Leu Ala Asp Gly
     370                 375                 380                
 Leu Gly Pro His Pro Cys Phe Leu Leu Leu Leu Ile Leu Ser Ala Phe
 385                 390                 395                 400
 Pro Val Leu Tyr Leu Asp Leu Ala Pro Ser Thr Phe Leu
                 405                 410            



      <210> 284
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 284
 Met Gly Lys Asp Phe Arg Tyr Tyr Phe Gln His Pro Trp Ser Arg Met
   1               5                  10                  15    
 Ile Val Ala Tyr Leu Val Ile Phe Phe Asn Phe Leu Ile Phe Ala Glu
              20                  25                  30        
 Asp Pro Val Ser His Ser Gln Thr Glu Ala Asn Val Ile Val Val Gly
          35                  40                  45            
 Asn Cys Phe Ser Phe Val Thr Asn Lys Tyr Pro Arg Gly Val Gly Trp
      50                  55                  60                
 Arg Ile Leu Lys Val Leu Leu Trp Leu Leu Ala Ile Leu Thr Gly Leu
  65                  70                  75                  80
 Ile Ala Gly Lys Phe Leu Phe His Gln Arg Leu Phe Gly Gln Leu Leu
                  85                  90                  95    
 Arg Leu Lys Met Phe Arg Glu Asp His Gly Ser Trp Met Thr Met Phe
             100                 105                 110        
 Phe Ser Thr Ile Leu Phe Leu Phe Ile Phe Ser His Ile Tyr Asn Thr
         115                 120                 125            
 Ile Leu Leu Met Asp Gly Asn Met Gly Ala Tyr Ile Ile Thr Asp Tyr
     130                 135                 140                
 Met Gly Ile Arg Asn Glu Ser Phe Met Lys Leu Ala Ala Val Gly Thr
 145                 150                 155                 160
 Trp Met Gly Asp Phe Val Thr Ala Trp Met Val Thr Asp Met Met Leu
                 165                 170                 175    
 Gln Asp Lys Pro Tyr Pro Asp Trp Gly Lys Ser Ala Arg Ala Phe Trp
             180                 185                 190        
 Lys Lys Gly Asn Val Arg Ile Thr Leu Phe Trp Thr Val Leu Phe Thr
         195                 200                 205            
 Leu Thr Ser Val Val Val Leu Val Ile Thr Thr Asp Trp Ile Ser Trp
     210                 215                 220                
 Asp Lys Leu Asn Arg Gly Phe Leu Pro Ser Asp Glu Val Ser Arg Ala
 225                 230                 235                 240
 Phe Leu Ala Ser Phe Ile Leu Val Phe Asp Leu Leu Ile Val Met Gln
                 245                 250                 255    
 Asp Trp Glu Phe Pro His Phe Met Gly Asp Val Asp Val Asn Leu Pro
             260                 265                 270        
 Gly Leu His Thr Pro His Met Gln Phe Lys Ile Pro Phe Phe Gln Lys
         275                 280                 285            
 Ile Phe Lys Glu Glu Tyr Arg Ile His Ile Thr Gly Lys Trp Phe Asn
     290                 295                 300                
 Tyr Gly Ile Ile Phe Leu Val Leu Ile Leu Asp Leu Asn Met Trp Lys
 305                 310                 315                 320
 Asn Gln Ile Phe Tyr Lys Pro His Glu Tyr Gly Gln Tyr Ile Gly Pro
                 325                 330                 335    
 Gly Gln Lys Ile Tyr Thr Val Lys Asp Ser Glu Ser Leu Lys Asp Leu
             340                 345                 350        
 Asn Arg Thr Lys Leu Ser Trp Glu Trp Arg Ser Asn His Thr Asn Pro
         355                 360                 365            
 Arg Thr Asn Lys Thr Tyr Val Glu Gly Asp Met Phe Leu His Ser Arg
     370                 375                 380                
 Phe Ile Gly Ala Ser Leu Asp Val Lys Cys Leu Ala Phe Val Pro Ser
 385                 390                 395                 400
 Leu Ile Ala Phe Val Trp Phe Gly Phe Phe Ile Trp Phe Phe Gly Arg
                 405                 410                 415    
 Phe Leu Lys Asn Glu Pro Arg Met Glu Asn Gln Asp Lys Thr Tyr Thr
             420                 425                 430        
 Arg Met Lys Arg Lys Ser Pro Ser Glu His Ser Lys Asp Met Gly Ile
         435                 440                 445            
 Thr Arg Glu Asn Thr Gln Ala Ser Val Glu Asp Pro Leu Asn Asp Pro
     450                 455                 460                
 Ser Leu Val Cys Ile Arg Ser Asp Phe Asn Glu Ile Val Tyr Lys Ser
 465                 470                 475                 480
 Ser His Leu Thr Ser Glu Asn Leu Ser Ser Gln Leu Asn Glu Ser Thr
                 485                 490                 495    
 Ser Ala Thr Glu Ala Asp Gln Asp Pro Thr Thr Ser Lys Ser Thr Pro
             500                 505                 510        
 Thr Asn
        



      <210> 285
      <211> 939
      <212> PRT
      <213> Homo sapiens


      <400> 285
 Met Val Leu Pro Pro Ser Leu Met Val Ala Gly Val Tyr Cys Leu Val
   1               5                  10                  15    
 Val Ala Val Ile Phe Ala Thr Ile Lys Thr Val Asn Tyr Arg Leu His
              20                  25                  30        
 Ala Met Phe Asp Gln Gly Glu Ile Val Glu Lys Arg Ser Ser Thr Met
          35                  40                  45            
 Gly Glu Leu Glu Glu Glu Pro Ala Gln Gly Asp Ser Asn Pro Pro Arg
      50                  55                  60                
 Asp Pro Gly Val Glu Met Thr Val Phe Arg Lys Val Ser Ser Thr Pro
  65                  70                  75                  80
 Pro Val Arg Cys Ser Ser Gln His Ser Val Phe Gly Phe Asn Gln Val
                  85                  90                  95    
 Ser Glu Leu Leu Pro Arg Met Glu Asp Ser Gly Pro Leu Arg Asp Ile
             100                 105                 110        
 Lys Glu Leu Val Arg Glu Gln Gly Ser Asn Asn Val Ile Val Thr Ser
         115                 120                 125            
 Ala Asp Arg Glu Met Leu Lys Leu Ser Ser Gln Glu Lys Leu Ile Gly
     130                 135                 140                
 Asp Leu Pro Gln Thr Pro Pro Gly Ala Val Pro Asp Pro Ser Leu Ala
 145                 150                 155                 160
 Ser Thr Asp Ser Ser Glu Pro Ser Pro Leu Ala Gly Asp Gly Ala Pro
                 165                 170                 175    
 Trp Ser Gly Ser Ser Met Ala Asp Thr Pro Met Ser Pro Leu Leu Lys
             180                 185                 190        
 Gly Ser Leu Ser Gln Glu Leu Ser Lys Ser Phe Leu Thr Leu Thr Gln
         195                 200                 205            
 Pro Asp Arg Ala Leu Val Arg Thr Ser Ser Arg Arg Glu Gln Arg Arg
     210                 215                 220                
 Gly Ala Gly Gly Tyr Gln Pro Leu Asp Arg Arg Gly Ser Gly Glu Pro
 225                 230                 235                 240
 Thr Pro Gln Lys Ala Gly Ser Ser Asp Ser Cys Phe Ser Gly Thr Asp
                 245                 250                 255    
 Arg Glu Thr Leu Ser Ser Phe Lys Ser Glu Lys Thr Asn Ser Thr His
             260                 265                 270        
 Leu Asp Ser Pro Pro Gly Gly Pro Ala Pro Glu Gly Ser Asp Thr Asp
         275                 280                 285            
 Pro Pro Ser Glu Ala Glu Leu Pro Ala Ser Pro Asp Ala Gly Val Pro
     290                 295                 300                
 Ser Asp Asp Thr Leu Arg Ser Phe Asp Thr Val Ile Gly Ala Gly Thr
 305                 310                 315                 320
 Pro Pro Gly Leu Ala Glu Pro Leu Leu Val Val Arg Pro Lys Asp Leu
                 325                 330                 335    
 Ala Leu Leu Arg Pro Ser Lys Arg Gln Pro Pro Leu Arg Arg His Ser
             340                 345                 350        
 Pro Pro Gly Arg Ala Pro Arg Arg Pro Leu Leu Glu Gly Gly Gly Phe
         355                 360                 365            
 Phe Glu Asp Glu Asp Thr Ser Glu Gly Ser Glu Leu Ser Pro Ala Ser
     370                 375                 380                
 Ser Leu Arg Ser Gln Arg Arg Tyr Ser Thr Asp Ser Ser Ser Ser Thr
 385                 390                 395                 400
 Ser Cys Tyr Ser Pro Glu Ser Ser Arg Gly Ala Ala Gly Gly Pro Arg
                 405                 410                 415    
 Lys Arg Arg Ala Pro His Gly Ala Glu Glu Gly Thr Ala Val Pro Pro
             420                 425                 430        
 Lys Arg Pro Tyr Gly Thr Gln Arg Thr Pro Ser Thr Ala Ser Ala Lys
         435                 440                 445            
 Thr His Ala Arg Val Leu Ser Met Asp Gly Ala Gly Gly Asp Val Leu
     450                 455                 460                
 Arg Pro Pro Leu Ala Gly Cys Lys Ala Glu Leu Glu Ala Gln Val Gly
 465                 470                 475                 480
 Val Glu Gln Ala Ala Ser Glu Pro Val Val Leu Pro Ala Glu Ala Arg
                 485                 490                 495    
 Arg Gly Pro Ala Ala Asn Gln Pro Gly Trp Arg Gly Glu Leu Gln Glu
             500                 505                 510        
 Glu Gly Ala Val Gly Gly Ala Ala Glu Glu Thr Gly Arg Arg Asp Arg
         515                 520                 525            
 Ser Ser Ser Val Arg Arg Thr Gln Ala Ile Arg Arg Arg His Asn Ala
     530                 535                 540                
 Gly Ser Asn Pro Thr Pro Pro Ala Ser Val Met Gly Ser Pro Pro Ser
 545                 550                 555                 560
 Ser Leu Gln Glu Ala Gln Arg Gly Arg Ala Ala Ser His Ser Arg Ala
                 565                 570                 575    
 Leu Thr Leu Pro Ser Ala Leu His Phe Ala Ser Ser Leu Leu Leu Thr
             580                 585                 590        
 Arg Ala Gly Ala Asn Val His Glu Ala Cys Thr Phe Asp Asp Thr Ser
         595                 600                 605            
 Glu Gly Ala Val His Tyr Phe Tyr Asp Glu Ser Gly Val Arg Arg Ser
     610                 615                 620                
 Tyr Thr Phe Gly Leu Ala Gly Gly Gly Tyr Glu Asn Pro Val Gly Gln
 625                 630                 635                 640
 Gln Gly Glu Gln Thr Ala Asn Gly Ala Trp Asp Arg His Ser His Ser
                 645                 650                 655    
 Ser Ser Phe His Ser Ala Asp Val Pro Glu Ala Thr Gly Gly Leu Asn
             660                 665                 670        
 Leu Leu Gln Pro Arg Pro Val Val Leu Gln Gly Met Gln Val Arg Arg
         675                 680                 685            
 Val Pro Leu Glu Ile Pro Glu Asp Ser Leu His Glu Ser Gln Glu Gln
     690                 695                 700                
 Thr Leu Met Glu Glu Ala Pro Pro Arg Ala Gln His Ser Tyr Lys Tyr
 705                 710                 715                 720
 Trp Leu Leu Pro Gly Arg Trp Thr Ser Val Arg Tyr Glu Arg Leu Ala
                 725                 730                 735    
 Leu Leu Ala Leu Leu Asp Arg Thr Arg Gly Val Leu Glu Asn Ile Phe
             740                 745                 750        
 Gly Val Gly Leu Ser Ser Leu Val Ala Phe Leu Gly Tyr Leu Leu Leu
         755                 760                 765            
 Leu Lys Gly Phe Phe Thr Asp Ile Trp Val Phe Gln Phe Cys Leu Val
     770                 775                 780                
 Ile Ala Ser Cys Gln Tyr Ser Leu Leu Lys Ser Val Gln Pro Asp Ala
 785                 790                 795                 800
 Ala Ser Pro Met His Gly His Asn Trp Val Ile Ala Tyr Ser Arg Pro
                 805                 810                 815    
 Val Tyr Phe Cys Ile Cys Cys Leu Leu Ile Trp Leu Leu Asp Ala Leu
             820                 825                 830        
 Gly Ser Ala Gln Pro Phe Pro Pro Val Ser Leu Tyr Gly Leu Thr Leu
         835                 840                 845            
 Phe Ser Ala Ser Phe Phe Phe Cys Ala Arg Asp Val Ala Thr Val Phe
     850                 855                 860                
 Thr Leu Cys Phe Pro Phe Val Phe Leu Leu Gly Leu Leu Pro Gln Val
 865                 870                 875                 880
 Asn Thr Cys Pro Arg Pro Arg Ser Pro Pro Glu Ala Leu Pro Cys Leu
                 885                 890                 895    
 His Ile Cys Phe Ala Leu Thr Gln Phe Gly Asn Ser Asn Cys Pro Ala
             900                 905                 910        
 Glu Val His Ser Pro Asp Pro Phe Pro Thr Leu Val Arg Val Ala Gly
         915                 920                 925            
 Phe Phe Lys Pro Leu Ser Gly Ile Ser Leu Cys
     930                 935                



      <210> 286
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 286
 Met Gly Cys Asp Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln
   1               5                  10                  15    
 Pro Thr Leu Thr Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile
              20                  25                  30        
 Ala Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser
          35                  40                  45            
 Ser Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu
      50                  55                  60                
 Leu Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln
  65                  70                  75                  80
 Ser Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe
                  85                  90                  95    
 Ala Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met
             100                 105                 110        
 Ala Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met
         115                 120                 125            
 Gln Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val
     130                 135                 140                
 Leu His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala
 145                 150                 155                 160
 Asp Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Ala
                 165                 170                 175    
 Asn Thr Thr Ser Arg Gly His Leu Phe His Val Ser Arg Val Leu Gly
             180                 185                 190        
 Gln His His Val Asp Ala Lys Pro Trp Ser Asn Gln Thr Phe Pro Gly
         195                 200                 205            
 Leu Thr Pro Lys Asp Gly Ala Gly Thr Arg Val Ser Tyr Ala Phe Trp
     210                 215                 220                
 Ile Met Ala Leu Ile Asn Leu Pro Val Pro Met Ala Val Leu Met Leu
 225                 230                 235                 240
 Leu Ser Lys Glu Arg Leu Leu Thr Cys Cys Pro Gln Arg Arg Pro Leu
                 245                 250                 255    
 Leu Leu Ser Ala Asp Glu Leu Ala Leu Glu Thr Gln Pro Pro Glu Lys
             260                 265                 270        
 Glu Asp Ala Ser Ser Leu Pro Pro Lys Phe Gln Ser His Leu Gly His
         275                 280                 285            
 Glu Asp Leu Phe Ser Cys Cys Gln Arg Lys Asn Leu Arg Gly Ala Pro
     290                 295                 300                
 Tyr Ser Phe Phe Ala Ile His Ile Thr Gly Ala Leu Val Leu Phe Met
 305                 310                 315                 320
 Thr Asp Gly Leu Thr Gly Ala Tyr Ser Ala Phe Val Tyr Ser Tyr Ala
                 325                 330                 335    
 Val Glu Lys Pro Leu Ser Val Gly His Lys Val Ala Gly Tyr Leu Pro
             340                 345                 350        
 Ser Leu Phe Trp Gly Phe Ile Thr Leu Gly Arg Leu Leu Ser Ile Pro
         355                 360                 365            
 Ile Ser Ser Arg Met Lys Pro Ala Thr Met Val Phe Ile Asn Val Val
     370                 375                 380                
 Gly Val Val Val Thr Phe Leu Val Leu Leu Ile Phe Ser Tyr Asn Val
 385                 390                 395                 400
 Val Phe Leu Phe Val Gly Thr Ala Ser Leu Gly Leu Phe Leu Ser Ser
                 405                 410                 415    
 Thr Phe Pro Ser Met Leu Ala Tyr Thr Glu Asp Ser Leu Gln Tyr Lys
             420                 425                 430        
 Gly Cys Ala Thr Thr Val Leu Val Thr Gly Ala Gly Val Gly Glu Met
         435                 440                 445            
 Val Leu Gln Met Leu Val Gly Ser Ile Phe Gln Ala Gln Gly Ser Tyr
     450                 455                 460                
 Ser Phe Leu Val Cys Gly Val Ile Phe Gly Cys Leu Ala Phe Thr Phe
 465                 470                 475                 480
 Tyr Ile Leu Leu Leu Phe Phe His Arg Met His Pro Gly Leu Pro Ser
                 485                 490                 495    
 Val Pro Thr Gln Asp Arg Ser Ile Gly Met Glu Asn Ser Glu Cys Tyr
             500                 505                 510        
 Gln Arg
        



      <210> 287
      <211> 362
      <212> PRT
      <213> Homo sapiens


      <400> 287
 Met Glu Pro Pro Gly Arg Arg Glu Cys Pro Phe Pro Ser Trp Arg Phe
   1               5                  10                  15    
 Pro Gly Leu Leu Leu Ala Ala Met Val Leu Leu Leu Tyr Ser Phe Ser
              20                  25                  30        
 Asp Ala Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly
          35                  40                  45            
 Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys
      50                  55                  60                
 Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys
  65                  70                  75                  80
 Asp Arg Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg
                  85                  90                  95    
 Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro
             100                 105                 110        
 Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn
         115                 120                 125            
 Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys
     130                 135                 140                
 Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val
 145                 150                 155                 160
 Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser
                 165                 170                 175    
 Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp
             180                 185                 190        
 Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile
         195                 200                 205            
 Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys
     210                 215                 220                
 Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser
 225                 230                 235                 240
 Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys
                 245                 250                 255    
 Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser
             260                 265                 270        
 Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Gly Pro Arg
         275                 280                 285            
 Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro
     290                 295                 300                
 Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile
 305                 310                 315                 320
 Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr
                 325                 330                 335    
 Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu
             340                 345                 350        
 Thr His Arg Glu Val Lys Phe Thr Ser Leu
         355                 360        



      <210> 288
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 288
 Met Ala Thr Ser Leu Val Ile Val Val Ser Val Gln Ile Ala Leu Asp
   1               5                  10                  15    
 Thr Ser Tyr Trp Thr Phe Ile Asn His Val Phe Ile Trp Gly Ser Ile
              20                  25                  30        
 Ala Ile Tyr Phe Ser Ile Leu Phe Thr Met His Ser Asn Gly Ile Phe
          35                  40                  45            
 Gly Ile Phe Pro Asn Gln Phe Pro Phe Val Gly Asn Ala Arg His Ser
      50                  55                  60                
 Leu Thr Gln Lys Cys Ile Trp Leu Val Ile Leu Leu Thr Thr Val Ala
  65                  70                  75                  80
 Ser Val Met Pro Val Val Ala Phe Arg Phe Leu Lys Val Asp Leu Tyr
                  85                  90                  95    
 Pro Thr Leu Ser Asp Gln Ile Arg Arg Trp Gln Lys Ala Gln Lys Lys
             100                 105                 110        
 Ala Arg Pro Pro Ser Ser Arg Arg Pro Arg Thr Arg Arg Ser Ser Ser
         115                 120                 125            
 Arg Arg Ser Gly Tyr Ala Phe Ala His Gln Glu Gly Tyr Gly Glu Leu
     130                 135                 140                
 Ile Thr Ser Gly Lys Asn Met Arg Ala Lys Asn Pro Pro Pro Thr Ser
 145                 150                 155                 160
 Gly Leu Glu Lys Thr His Tyr Asn Ser Thr Ser Trp Ile Glu Asn Leu
                 165                 170                 175    
 Cys Lys Lys Thr Thr Asp Thr Val Ser Ser Phe Ser Gln Asp Lys Thr
             180                 185                 190        
 Val Lys Leu
         195



      <210> 289
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 289
 Met Asn Leu Gly Val Ser Met Leu Arg Ile Leu Phe Leu Leu Asp Val
   1               5                  10                  15    
 Gly Gly Ala Gln Val Leu Ala Thr Gly Lys Thr Pro Gly Ala Glu Ile
              20                  25                  30        
 Asp Phe Lys Tyr Ala Leu Ile Gly Thr Ala Val Gly Val Ala Ile Ser
          35                  40                  45            
 Ala Gly Phe Leu Ala Leu Lys Ile Cys Met Ile Arg Arg His Leu Phe
      50                  55                  60                
 Asp Asp Asp Ser Ser Asp Leu Lys Ser Thr Pro Gly Gly Leu Ser Gly
  65                  70                  75                  80
 Glu Gly Cys Gly Ala Arg Ala Trp Leu Cys Pro Thr Gln Arg Gly Thr
                  85                  90                  95    
 Glu Gly His Ser Val Met Leu Ala Thr Ala Arg Met Asn Pro Gln Ala
             100                 105                 110        
 Gln Ser Pro Thr Gly Cys Lys Gly Arg Gln
         115                 120        



      <210> 290
      <211> 389
      <212> PRT
      <213> Homo sapiens


      <400> 290
 Met Lys Thr Gly His Phe Glu Ile Val Thr Met Leu Leu Ala Thr Met
   1               5                  10                  15    
 Ile Leu Val Asp Ile Phe Gln Val Lys Ala Glu Val Leu Asp Met Ala
              20                  25                  30        
 Asp Asn Ala Phe Asp Asp Glu Tyr Leu Lys Cys Thr Asp Arg Met Glu
          35                  40                  45            
 Ile Lys Tyr Val Pro Gln Leu Leu Lys Glu Glu Lys Ala Ser His Gln
      50                  55                  60                
 Gln Leu Asp Thr Val Trp Glu Asn Ala Lys Ala Lys Trp Ala Ala Arg
  65                  70                  75                  80
 Lys Thr Gln Ile Phe Leu Pro Met Asn Phe Lys Asp Asn His Gly Ile
                  85                  90                  95    
 Ala Leu Met Ala Tyr Ile Ser Glu Ala Gln Glu Gln Thr Pro Phe Tyr
             100                 105                 110        
 His Leu Phe Ser Glu Ala Val Lys Met Ala Gly Gln Ser Arg Glu Asp
         115                 120                 125            
 Tyr Ile Tyr Gly Phe Gln Phe Lys Ala Phe His Phe Tyr Leu Thr Arg
     130                 135                 140                
 Ala Leu Gln Leu Leu Arg Lys Pro Cys Glu Ala Ser Ser Lys Thr Val
 145                 150                 155                 160
 Val Tyr Arg Thr Ser Gln Gly Thr Ser Phe Thr Phe Gly Gly Leu Asn
                 165                 170                 175    
 Gln Ala Arg Phe Gly His Phe Thr Leu Ala Tyr Ser Ala Lys Pro Gln
             180                 185                 190        
 Ala Ala Asn Asp Gln Leu Thr Val Leu Ser Ile Tyr Thr Cys Leu Gly
         195                 200                 205            
 Val Asp Ile Glu Asn Phe Leu Asp Lys Glu Ser Glu Arg Ile Thr Leu
     210                 215                 220                
 Ile Pro Leu Asn Glu Val Phe Gln Val Ser Gln Glu Gly Ala Gly Asn
 225                 230                 235                 240
 Asn Leu Ile Leu Gln Ser Ile Asn Lys Thr Cys Ser His Tyr Glu Cys
                 245                 250                 255    
 Ala Phe Leu Gly Gly Leu Lys Thr Glu Asn Cys Ile Glu Asn Leu Glu
             260                 265                 270        
 Tyr Phe Gln Pro Ile Tyr Val Tyr Asn Pro Gly Glu Lys Asn Gln Lys
         275                 280                 285            
 Leu Glu Asp His Ser Glu Lys Asn Trp Lys Leu Glu Asp His Gly Glu
     290                 295                 300                
 Lys Asn Gln Lys Leu Glu Asp His Gly Val Lys Ile Leu Glu Pro Thr
 305                 310                 315                 320
 Gln Ile Pro Gly Met Lys Ile Pro Glu Pro Phe Pro Leu Pro Glu Asp
                 325                 330                 335    
 Lys Ser Gln Gly Asn Ile Asn Asn Pro Thr Pro Gly Pro Val Pro Val
             340                 345                 350        
 Pro Gly Pro Lys Ser His Pro Ser Ala Ser Ser Gly Lys Leu Leu Leu
         355                 360                 365            
 Pro Gln Phe Gly Met Val Ile Ile Leu Ile Ser Val Ser Ala Ile Asn
     370                 375                 380                
 Leu Phe Val Ala Leu
 385                



      <210> 291
      <211> 176
      <212> PRT
      <213> Homo sapiens


      <400> 291
 Met Gly Lys Ala Ala Ala Ala Val Ala Phe Gly Ala Glu Val Gly Val
   1               5                  10                  15    
 Arg Leu Ala Leu Phe Ala Ala Phe Leu Val Thr Glu Leu Leu Pro Pro
              20                  25                  30        
 Phe Gln Arg Leu Ile Gln Pro Glu Glu Met Trp Leu Tyr Arg Asn Pro
          35                  40                  45            
 Tyr Val Glu Ala Glu Tyr Phe Pro Thr Lys Pro Met Phe Val Ile Ala
      50                  55                  60                
 Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala Lys Phe Leu Lys Lys
  65                  70                  75                  80
 Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu Ala Ala Ser Leu Ala
                  85                  90                  95    
 Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile Lys Leu Ile Val Gly
             100                 105                 110        
 Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe Pro Asp Gly Leu Ala
         115                 120                 125            
 His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp Val Val Asn Glu Gly
     130                 135                 140                
 Arg Lys Ser Phe Pro Ser Gly His Ser Ser Cys Met Asn Ile Ile Trp
 145                 150                 155                 160
 Thr Leu Pro Tyr Ala Cys Phe His Ile Ile Glu Phe Asn Leu Glu Ser
                 165                 170                 175    





      <210> 292
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 292
 Met Trp Val Leu Gly Ile Ala Ala Thr Phe Cys Gly Leu Phe Leu Leu
   1               5                  10                  15    
 Pro Gly Phe Ala Leu Gln Ile Gln Cys Tyr Gln Cys Glu Glu Phe Gln
              20                  25                  30        
 Leu Asn Asn Asp Cys Ser Ser Pro Glu Phe Ile Val Asn Cys Thr Val
          35                  40                  45            
 Asn Val Gln Asp Met Cys Gln Lys Glu Val Met Glu Gln Ser Ala Gly
      50                  55                  60                
 Ile Met Tyr Arg Lys Ser Cys Ala Ser Ser Ala Ala Cys Leu Ile Ala
  65                  70                  75                  80
 Ser Ala Gly Tyr Gln Ser Phe Cys Ser Pro Gly Lys Leu Asn Ser Val
                  85                  90                  95    
 Cys Ile Ser Cys Cys Asn Thr Pro Leu Cys Asn Gly Pro Arg Pro Lys
             100                 105                 110        
 Lys Arg Gly Ser Ser Ala Ser Ala Leu Arg Pro Gly Leu Arg Thr Thr
         115                 120                 125            
 Ile Leu Phe Leu Lys Leu Ala Leu Phe Ser Ala His Cys
     130                 135                 140    



      <210> 293
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 293
 Met Ala Leu Ile Phe Arg Thr Ala Met Gln Ser Val Gly Leu Leu Leu
   1               5                  10                  15    
 Ser Leu Leu Gly Trp Ile Leu Ser Ile Ile Thr Thr Tyr Leu Pro His
              20                  25                  30        
 Trp Lys Asn Leu Asn Leu Asp Leu Asn Glu Met Glu Asn Trp Thr Met
          35                  40                  45            
 Gly Leu Trp Gln Thr Cys Val Ile Gln Glu Glu Val Gly Met Gln Cys
      50                  55                  60                
 Lys Asp Phe Asp Ser Phe Leu Ala Leu Pro Ala Glu Leu Arg Val Ser
  65                  70                  75                  80
 Arg Ile Leu Met Phe Leu Ser Asn Gly Leu Gly Phe Leu Gly Leu Leu
                  85                  90                  95    
 Val Ser Gly Phe Gly Leu Asp Cys Leu Arg Ile Gly Glu Ser Gln Arg
             100                 105                 110        
 Asp Leu Lys Arg Arg Leu Leu Ile Leu Gly Gly Ile Leu Ser Trp Ala
         115                 120                 125            
 Ser Gly Ile Thr Ala Leu Val Pro Val Ser Trp Val Ala His Lys Thr
     130                 135                 140                
 Val Gln Glu Phe Trp Asp Glu Asn Val Pro Asp Phe Val Pro Arg Arg
 145                 150                 155                 160
 Val Ser Ala Pro Leu Cys Ser Leu Leu Gln Pro Arg Ser Pro Ser Phe
                 165                 170                 175    
 Gly Pro Leu Arg Ser Gly Thr Asn Thr Arg Ser Ser Ser Arg Thr Gly
             180                 185                 190        
 Asp Glu Lys His Gln Pro Glu Thr Leu Ser Gln Lys Gly Gln Ala Ser
         195                 200                 205            
 Ala Val Gln Glu Thr Leu Ala Gln His Trp Ile Trp
     210                 215                 220



      <210> 294
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 294
 Met Ala Ile Ser Gly Val Pro Val Leu Gly Phe Phe Ile Ile Ala Val
   1               5                  10                  15    
 Leu Met Ser Ala Gln Glu Ser Trp Ala Ile Lys Glu Glu His Val Ile
              20                  25                  30        
 Ile Gln Ala Glu Phe Tyr Leu Asn Pro Asp Gln Ser Gly Glu Phe Met
          35                  40                  45            
 Phe Asp Phe Asp Gly Asp Glu Ile Phe His Val Asp Met Ala Lys Lys
      50                  55                  60                
 Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Phe Ala Ser Phe Glu
  65                  70                  75                  80
 Ala Gln Gly Ala Leu Ala Asn Ile Ala Val Asp Lys Ala Asn Leu Glu
                  85                  90                  95    
 Ile Met Thr Lys Arg Ser Asn Tyr Thr Pro Ile Thr Asn Val Pro Pro
             100                 105                 110        
 Glu Val Thr Val Leu Thr Asn Ser Pro Val Glu Leu Arg Glu Pro Asn
         115                 120                 125            
 Val Leu Ile Cys Phe Ile Asp Lys Phe Thr Pro Pro Val Val Asn Val
     130                 135                 140                
 Thr Trp Leu Arg Asn Gly Leu Phe Arg Lys Phe His Tyr Leu Pro Phe
 145                 150                 155                 160
 Leu Pro Ser Thr Glu Asp Val Tyr Asp Cys Arg Val Glu His Trp Gly
                 165                 170                 175    
 Leu Asp Glu Pro Leu Leu Lys His Trp Glu Phe Asp Ala Pro Ser Pro
             180                 185                 190        
 Leu Pro Glu Thr Thr Glu Asn Val Val Cys Ala Leu Gly Leu Thr Val
         195                 200                 205            
 Gly Leu Val Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys Gly Val
     210                 215                 220                
 Arg Lys Ser Asn Ala Ala Glu Arg Arg Gly Pro Leu
 225                 230                 235    



      <210> 295
      <211> 532
      <212> PRT
      <213> Homo sapiens


      <400> 295
 Met Ala Pro Ser Phe Thr Ala Arg Ile Gln Leu Phe Leu Leu Arg Ala
   1               5                  10                  15    
 Leu Gly Phe Leu Ile Gly Leu Val Gly Arg Ala Ala Leu Val Leu Gly
              20                  25                  30        
 Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg Pro Val Thr Glu Pro Leu
          35                  40                  45            
 Leu Leu Leu Ser Gly Met Gln Leu Ala Lys Leu Ile Arg Gln Arg Lys
      50                  55                  60                
 Val Lys Cys Ile Asp Val Val Gln Ala Tyr Ile Asn Arg Ile Lys Asp
  65                  70                  75                  80
 Val Asn Pro Met Ile Asn Gly Ile Val Lys Tyr Arg Phe Glu Glu Ala
                  85                  90                  95    
 Met Lys Glu Ala His Ala Val Asp Gln Lys Leu Ala Glu Lys Gln Glu
             100                 105                 110        
 Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro Phe Leu Gly Val Pro Leu
         115                 120                 125            
 Thr Val Lys Glu Ala Phe Gln Leu Gln Gly Met Pro Asn Ser Ser Gly
     130                 135                 140                
 Leu Met Asn Arg Arg Asp Ala Ile Ala Lys Thr Asp Ala Thr Val Gly
 145                 150                 155                 160
 Ala Leu Leu Lys Gly Ala Gly Ala Ile Pro Leu Gly Ile Thr Asn Cys
                 165                 170                 175    
 Ser Glu Leu Cys Met Trp Tyr Glu Ser Ser Asn Lys Ile Tyr Gly Arg
             180                 185                 190        
 Ser Asn Asn Pro Tyr Asp Leu Gln His Ile Val Gly Gly Ser Ser Gly
         195                 200                 205            
 Gly Glu Gly Cys Thr Leu Ala Ala Ala Cys Ser Val Ile Gly Val Gly
     210                 215                 220                
 Ser Asp Ile Gly Gly Ser Ile Arg Met Pro Ala Phe Phe Asn Gly Ile
 225                 230                 235                 240
 Phe Gly His Lys Pro Ser Pro Gly Val Val Pro Asn Lys Gly Gln Phe
                 245                 250                 255    
 Pro Leu Ala Val Gly Ala Gln Glu Leu Phe Leu Cys Thr Gly Pro Met
             260                 265                 270        
 Cys Arg Tyr Ala Glu Asp Leu Ala Pro Met Leu Lys Val Met Ala Gly
         275                 280                 285            
 Pro Gly Ile Lys Arg Leu Lys Leu Asp Thr Lys Val His Leu Lys Asp
     290                 295                 300                
 Leu Lys Phe Tyr Trp Met Glu His Asp Gly Gly Ser Phe Leu Met Ser
 305                 310                 315                 320
 Lys Val Asp Gln Asp Leu Ile Met Thr Gln Lys Lys Val Ala Val His
                 325                 330                 335    
 Leu Glu Thr Ile Leu Gly Ala Ser Val Gln His Val Lys Leu Lys Lys
             340                 345                 350        
 Met Lys Tyr Ser Phe Gln Leu Trp Ile Ala Met Met Ser Ala Lys Gly
         355                 360                 365            
 His Asp Gly Lys Glu Pro Val Lys Phe Val Asp Leu Leu Gly Asp His
     370                 375                 380                
 Gly Lys His Val Ser Pro Leu Trp Glu Leu Ile Lys Trp Cys Leu Gly
 385                 390                 395                 400
 Leu Ser Val Tyr Thr Ile Pro Ser Ile Gly Leu Ala Leu Leu Glu Glu
                 405                 410                 415    
 Lys Leu Arg Tyr Ser Asn Glu Lys Tyr Gln Lys Phe Lys Ala Val Glu
             420                 425                 430        
 Glu Ser Leu Arg Lys Glu Leu Val Asp Met Leu Gly Asp Asp Gly Val
         435                 440                 445            
 Phe Leu Tyr Pro Ser His Pro Thr Val Ala Pro Lys His His Val Pro
     450                 455                 460                
 Leu Thr Arg Pro Phe Asn Phe Ala Tyr Thr Gly Val Phe Ser Ala Leu
 465                 470                 475                 480
 Gly Leu Pro Val Thr Gln Cys Pro Leu Gly Leu Asn Ala Lys Gly Leu
                 485                 490                 495    
 Pro Leu Gly Ile Gln Val Val Ala Gly Pro Phe Asn Asp His Leu Thr
             500                 505                 510        
 Leu Ala Val Ala Gln Tyr Leu Glu Lys Thr Phe Gly Gly Trp Val Cys
         515                 520                 525            
 Pro Gly Lys Phe
     530        



      <210> 296
      <211> 595
      <212> PRT
      <213> Homo sapiens


      <400> 296
 Met Lys Phe Phe Ser Tyr Ile Leu Val Tyr Arg Arg Phe Leu Phe Val
   1               5                  10                  15    
 Val Phe Thr Val Leu Val Leu Leu Pro Leu Pro Ile Val Leu His Thr
              20                  25                  30        
 Lys Glu Ala Glu Cys Ala Tyr Thr Leu Phe Val Val Ala Thr Phe Trp
          35                  40                  45            
 Leu Thr Glu Ala Leu Pro Leu Ser Val Thr Ala Leu Leu Pro Ser Leu
      50                  55                  60                
 Met Leu Pro Met Phe Gly Ile Met Pro Ser Lys Lys Val Ala Ser Ala
  65                  70                  75                  80
 Tyr Phe Lys Asp Phe His Leu Leu Leu Ile Gly Val Ile Cys Leu Ala
                  85                  90                  95    
 Thr Ser Ile Glu Lys Trp Asn Leu His Lys Arg Ile Ala Leu Lys Met
             100                 105                 110        
 Val Met Met Val Gly Val Asn Pro Ala Trp Leu Thr Leu Gly Phe Met
         115                 120                 125            
 Ser Ser Thr Ala Phe Leu Ser Met Trp Leu Ser Asn Thr Ser Thr Ala
     130                 135                 140                
 Ala Met Val Met Pro Ile Ala Glu Ala Val Val Gln Gln Ile Ile Asn
 145                 150                 155                 160
 Ala Glu Ala Glu Val Glu Ala Thr Gln Met Thr Tyr Phe Asn Gly Ser
                 165                 170                 175    
 Thr Asn His Gly Leu Glu Ile Asp Glu Ser Val Asn Gly His Glu Ile
             180                 185                 190        
 Asn Glu Arg Lys Glu Lys Thr Lys Pro Val Pro Gly Tyr Asn Asn Asp
         195                 200                 205            
 Thr Gly Lys Ile Ser Ser Lys Val Glu Leu Glu Lys Asn Ser Gly Met
     210                 215                 220                
 Arg Thr Lys Tyr Arg Thr Lys Lys Gly His Val Thr Arg Lys Leu Thr
 225                 230                 235                 240
 Cys Leu Cys Ile Ala Tyr Ser Ser Thr Ile Gly Gly Leu Thr Thr Ile
                 245                 250                 255    
 Thr Gly Thr Ser Thr Asn Leu Ile Phe Ala Glu Tyr Phe Asn Thr Arg
             260                 265                 270        
 Tyr Pro Asp Cys Arg Cys Leu Asn Phe Gly Ser Trp Phe Thr Phe Ser
         275                 280                 285            
 Phe Pro Ala Ala Leu Ile Ile Leu Leu Leu Ser Trp Ile Trp Leu Gln
     290                 295                 300                
 Trp Leu Phe Leu Gly Phe Asn Phe Lys Glu Met Phe Lys Cys Gly Lys
 305                 310                 315                 320
 Thr Lys Thr Val Gln Gln Lys Ala Cys Ala Glu Val Ile Lys Gln Glu
                 325                 330                 335    
 Tyr Gln Lys Leu Gly Pro Ile Arg Tyr Gln Glu Ile Val Thr Leu Val
             340                 345                 350        
 Leu Phe Ile Ile Met Ala Leu Leu Trp Phe Ser Arg Asp Pro Gly Phe
         355                 360                 365            
 Val Pro Gly Trp Ser Ala Leu Phe Ser Glu Tyr Pro Gly Phe Ala Thr
     370                 375                 380                
 Asp Ser Thr Val Ala Leu Leu Ile Gly Leu Leu Phe Phe Leu Ile Pro
 385                 390                 395                 400
 Ala Lys Thr Leu Thr Lys Thr Thr Pro Thr Gly Glu Ile Val Ala Phe
                 405                 410                 415    
 Asp Tyr Ser Pro Leu Ile Thr Trp Lys Glu Phe Gln Ser Phe Met Pro
             420                 425                 430        
 Trp Asp Ile Ala Ile Leu Val Gly Gly Gly Phe Ala Leu Ala Asp Gly
         435                 440                 445            
 Cys Glu Glu Ser Gly Leu Ser Lys Trp Ile Gly Asn Lys Leu Ser Pro
     450                 455                 460                
 Leu Gly Ser Leu Pro Ala Trp Leu Ile Ile Leu Ile Ser Ser Leu Met
 465                 470                 475                 480
 Val Thr Ser Leu Thr Glu Val Ala Ser Asn Pro Ala Thr Ile Thr Leu
                 485                 490                 495    
 Phe Leu Pro Ile Leu Ser Pro Leu Ala Glu Ala Ile His Val Asn Pro
             500                 505                 510        
 Leu Tyr Ile Leu Ile Pro Ser Thr Leu Cys Thr Ser Phe Ala Phe Leu
         515                 520                 525            
 Leu Pro Val Ala Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly His
     530                 535                 540                
 Leu Lys Val Ile Asp Met Val Lys Ala Gly Leu Gly Val Asn Ile Val
 545                 550                 555                 560
 Gly Val Ala Val Val Met Leu Gly Ile Cys Thr Trp Ile Val Pro Met
                 565                 570                 575    
 Phe Asp Leu Tyr Thr Tyr Pro Ser Trp Ala Pro Ala Met Ser Asn Glu
             580                 585                 590        
 Thr Met Pro
         595



      <210> 297
      <211> 302
      <212> PRT
      <213> Homo sapiens


      <400> 297
 Met Ala Thr Leu Ser Val Ile Gly Ser Ser Ser Leu Ile Ala Tyr Ala
   1               5                  10                  15    
 Val Phe His Asn Ile Gln Lys Ser Pro Glu Ile Arg Pro Leu Phe Tyr
              20                  25                  30        
 Leu Ser Phe Cys Asp Leu Leu Leu Gly Leu Cys Trp Leu Thr Glu Thr
          35                  40                  45            
 Leu Leu Tyr Gly Ala Ser Val Ala Asn Lys Asp Ile Ile Cys Tyr Asn
      50                  55                  60                
 Leu Gln Ala Val Gly Gln Val Ile Asp Tyr Thr Cys Arg Val Gly Gln
  65                  70                  75                  80
 Met Ala Phe Val Phe Ser Ser Leu Ile Pro Leu Leu Leu Met Thr Pro
                  85                  90                  95    
 Val Phe Cys Leu Gly Asn Thr Ser Glu Cys Phe Gln Asn Phe Ser Gln
             100                 105                 110        
 Ser His Lys Cys Ile Leu Met His Ser Pro Pro Ser Ala Met Ala Glu
         115                 120                 125            
 Leu Pro Pro Ser Ala Asn Thr Ser Val Cys Ser Thr Leu Tyr Phe Tyr
     130                 135                 140                
 Gly Ile Ala Ile Phe Leu Gly Ser Phe Val Leu Ser Leu Leu Thr Ile
 145                 150                 155                 160
 Met Val Leu Leu Ile Arg Ala Gln Thr Leu Tyr Lys Lys Phe Val Lys
                 165                 170                 175    
 Ser Thr Gly Phe Leu Gly Ser Glu Gln Trp Ala Val Ile His Ile Val
             180                 185                 190        
 Asp Gln Arg Val Arg Phe Tyr Pro Val Ala Phe Phe Cys Cys Trp Gly
         195                 200                 205            
 Pro Ala Val Ile Leu Met Ile Ile Lys Leu Thr Lys Pro Gln Asp Thr
     210                 215                 220                
 Lys Leu His Met Ala Leu Tyr Val Leu Gln Ala Leu Thr Ala Thr Ser
 225                 230                 235                 240
 Gln Gly Leu Leu Asn Cys Gly Val Tyr Gly Trp Thr Gln His Lys Phe
                 245                 250                 255    
 His Gln Leu Lys Gln Glu Ala Arg Arg Asp Ala Asp Thr Gln Thr Pro
             260                 265                 270        
 Leu Leu Cys Ser Gln Lys Arg Phe Tyr Ser Arg Gly Leu Asn Ser Leu
         275                 280                 285            
 Glu Ser Thr Leu Thr Phe Pro Ala Ser Thr Ser Thr Ile Phe
     290                 295                 300        



      <210> 298
      <211> 703
      <212> PRT
      <213> Homo sapiens


      <400> 298
 Met Arg Leu Trp Lys Ala Val Val Val Thr Leu Ala Phe Met Ser Val
   1               5                  10                  15    
 Asp Ile Cys Val Thr Thr Ala Ile Tyr Val Phe Ser His Leu Asp Arg
              20                  25                  30        
 Ser Leu Leu Glu Asp Ile Arg His Phe Asn Ile Phe Asp Ser Val Leu
          35                  40                  45            
 Asp Leu Trp Ala Ala Cys Leu Tyr Arg Ser Cys Leu Leu Leu Gly Ala
      50                  55                  60                
 Thr Ile Gly Val Ala Lys Asn Ser Ala Leu Gly Pro Arg Arg Leu Arg
  65                  70                  75                  80
 Ala Ser Trp Leu Val Ile Thr Leu Val Cys Leu Phe Val Gly Ile Tyr
                  85                  90                  95    
 Ala Met Val Lys Leu Leu Leu Phe Ser Glu Val Arg Arg Pro Ile Arg
             100                 105                 110        
 Asp Pro Trp Phe Trp Ala Leu Phe Val Trp Thr Tyr Ile Ser Leu Gly
         115                 120                 125            
 Ala Ser Phe Leu Leu Trp Trp Leu Leu Ser Thr Val Arg Pro Gly Thr
     130                 135                 140                
 Gln Ala Leu Glu Pro Gly Ala Ala Thr Glu Ala Glu Gly Phe Pro Gly
 145                 150                 155                 160
 Ser Gly Arg Pro Pro Pro Glu Gln Ala Ser Gly Ala Thr Leu Gln Lys
                 165                 170                 175    
 Leu Leu Ser Tyr Thr Lys Pro Asp Val Ala Phe Leu Val Ala Ala Ser
             180                 185                 190        
 Phe Phe Leu Ile Val Ala Ala Leu Gly Glu Thr Phe Leu Pro Tyr Tyr
         195                 200                 205            
 Thr Gly Arg Ala Ile Asp Gly Ile Val Ile Gln Lys Ser Met Asp Gln
     210                 215                 220                
 Phe Ser Thr Ala Val Val Ile Val Cys Leu Leu Ala Ile Gly Ser Ser
 225                 230                 235                 240
 Phe Ala Ala Gly Ile Arg Gly Gly Ile Phe Thr Leu Ile Phe Ala Arg
                 245                 250                 255    
 Leu Asn Ile Arg Leu Arg Asn Cys Leu Phe Arg Ser Leu Val Ser Gln
             260                 265                 270        
 Glu Thr Ser Phe Phe Asp Glu Asn Arg Thr Gly Asp Leu Ile Ser Arg
         275                 280                 285            
 Leu Thr Ser Asp Thr Thr Met Val Ser Asp Leu Val Ser Gln Asn Ile
     290                 295                 300                
 Asn Val Phe Leu Arg Asn Thr Val Lys Val Thr Gly Val Val Val Phe
 305                 310                 315                 320
 Met Phe Ser Leu Ser Trp Gln Leu Ser Leu Val Thr Phe Met Gly Phe
                 325                 330                 335    
 Pro Ile Ile Met Met Val Ser Asn Ile Tyr Gly Lys Tyr Tyr Lys Arg
             340                 345                 350        
 Leu Ser Lys Glu Val Gln Asn Ala Leu Ala Arg Ala Ser Asn Thr Ala
         355                 360                 365            
 Glu Glu Thr Ile Ser Ala Met Lys Thr Val Arg Ser Phe Ala Asn Glu
     370                 375                 380                
 Glu Glu Glu Ala Glu Val Tyr Leu Arg Lys Leu Gln Gln Val Tyr Lys
 385                 390                 395                 400
 Leu Asn Arg Lys Glu Ala Ala Ala Tyr Met Tyr Tyr Val Trp Gly Ser
                 405                 410                 415    
 Gly Leu Thr Leu Leu Val Val Gln Val Ser Ile Leu Tyr Tyr Gly Gly
             420                 425                 430        
 His Leu Val Ile Ser Gly Gln Met Thr Ser Gly Asn Leu Ile Ala Phe
         435                 440                 445            
 Ile Ile Tyr Glu Phe Val Leu Gly Asp Cys Met Glu Asn Val Ser Phe
     450                 455                 460                
 Ser Leu Ser Pro Gly Lys Val Thr Ala Leu Val Gly Pro Ser Gly Ser
 465                 470                 475                 480
 Gly Lys Ser Ser Cys Val Asn Ile Leu Glu Asn Phe Tyr Pro Leu Glu
                 485                 490                 495    
 Gly Gly Arg Val Leu Leu Asp Gly Lys Pro Ile Ser Ala Tyr Asp His
             500                 505                 510        
 Lys Tyr Leu His Arg Val Ile Ser Leu Val Ser Gln Glu Pro Val Leu
         515                 520                 525            
 Phe Ala Arg Ser Ile Thr Asp Asn Ile Ser Tyr Gly Leu Pro Thr Val
     530                 535                 540                
 Pro Phe Glu Met Val Val Glu Ala Ala Gln Lys Ala Asn Ala His Gly
 545                 550                 555                 560
 Phe Ile Met Glu Leu Gln Asp Gly Tyr Ser Thr Glu Thr Gly Glu Lys
                 565                 570                 575    
 Gly Ala Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Met Ala Arg
             580                 585                 590        
 Ala Leu Val Arg Asn Pro Pro Val Leu Ile Leu Asp Glu Ala Thr Ser
         595                 600                 605            
 Ala Leu Asp Ala Glu Ser Glu Tyr Leu Ile Gln Gln Ala Ile His Gly
     610                 615                 620                
 Asn Leu Gln Lys His Thr Val Leu Ile Ile Ala His Arg Leu Ser Thr
 625                 630                 635                 640
 Val Glu His Ala His Leu Ile Val Val Leu Asp Lys Gly Arg Val Val
                 645                 650                 655    
 Gln Gln Gly Thr His Gln Gln Leu Leu Ala Gln Gly Gly Leu Tyr Ala
             660                 665                 670        
 Lys Leu Val Gln Arg Gln Met Leu Gly Leu Gln Pro Ala Ala Asp Phe
         675                 680                 685            
 Thr Ala Gly His Asn Glu Pro Val Ala Asn Gly Ser His Lys Ala
     690                 695                 700            



      <210> 299
      <211> 196
      <212> PRT
      <213> Homo sapiens


      <400> 299
 Met Ala Arg Leu Gly Ala Leu Leu Leu Ala Ala Ala Leu Gly Ala Leu
   1               5                  10                  15    
 Leu Ser Phe Ala Leu Leu Ala Ala Ala Val Ala Ser Asp Tyr Trp Tyr
              20                  25                  30        
 Ile Leu Glu Val Ala Asp Ala Gly Asn Gly Ser Ala Trp Pro Gly Arg
          35                  40                  45            
 Ala Glu Leu Leu Ser Ser His Ser Gly Leu Trp Arg Ile Cys Glu Val
      50                  55                  60                
 Leu His Arg Ala Val Ile Val Val Leu Pro Leu Ser Leu Val Leu Leu
  65                  70                  75                  80
 Val Cys Gly Trp Ile Cys Gly Leu Leu Ser Ser Leu Ala Gln Ser Val
                  85                  90                  95    
 Ser Leu Leu Leu Phe Thr Gly Cys Tyr Phe Leu Leu Gly Ser Val Leu
             100                 105                 110        
 Thr Leu Ala Gly Val Ser Ile Tyr Ile Ser Tyr Ser His Leu Ala Phe
         115                 120                 125            
 Ala Glu Thr Val Gln Gln Tyr Gly Pro Gln His Met Gln Gly Val Arg
     130                 135                 140                
 Val Ser Phe Gly Trp Ser Met Ala Leu Ala Trp Gly Ser Cys Ala Leu
 145                 150                 155                 160
 Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala Ala Trp Thr Leu Ser
                 165                 170                 175    
 Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro Gln Gln Val Gly Gly
             180                 185                 190        
 Arg Gly Gly Asp
         195    



      <210> 300
      <211> 236
      <212> PRT
      <213> Homo sapiens


      <400> 300
 Met Pro Phe Arg Met Ser Gly Tyr Ile Pro Phe Gly Thr Pro Ile Val
   1               5                  10                  15    
 Val Gly Leu Leu Leu Pro Asn Gln Thr Leu Ala Ser Thr Val Phe Trp
              20                  25                  30        
 Gln Trp Leu Asn Gln Ser His Asn Ala Cys Val Asn Tyr Ala Asn Arg
          35                  40                  45            
 Asn Ala Thr Lys Pro Ser Pro Ala Ser Lys Phe Ile Gln Gly Tyr Leu
      50                  55                  60                
 Gly Ala Val Ile Ser Ala Val Ser Ile Ala Val Gly Leu Asn Val Leu
  65                  70                  75                  80
 Val Gln Lys Ala Asn Lys Phe Thr Pro Ala Thr Arg Leu Leu Ile Gln
                  85                  90                  95    
 Arg Phe Val Pro Phe Pro Ala Val Ala Ser Ala Asn Ile Cys Asn Val
             100                 105                 110        
 Val Leu Met Arg Tyr Gly Glu Leu Glu Glu Gly Ile Asp Val Leu Asp
         115                 120                 125            
 Ser Asp Gly Asn Leu Val Gly Ser Ser Lys Ile Ala Ala Arg His Ala
     130                 135                 140                
 Leu Leu Glu Thr Ala Leu Thr Arg Val Val Leu Pro Met Pro Ile Leu
 145                 150                 155                 160
 Val Leu Pro Pro Ile Val Met Ser Met Leu Glu Lys Thr Ala Leu Leu
                 165                 170                 175    
 Gln Ala Arg Pro Arg Leu Leu Leu Pro Val Gln Ser Leu Val Cys Leu
             180                 185                 190        
 Ala Ala Phe Gly Leu Ala Leu Pro Leu Ala Ile Ser Leu Phe Pro Gln
         195                 200                 205            
 Met Ser Glu Ile Glu Thr Ser Gln Leu Glu Pro Glu Ile Ala Gln Ala
     210                 215                 220                
 Thr Ser Ser Arg Thr Val Val Tyr Asn Lys Gly Leu
 225                 230                 235    



      <210> 301
      <211> 547
      <212> PRT
      <213> Homo sapiens


      <400> 301
 Met Ala Val Ile Ser Leu Leu Phe Leu Ala Val Met Tyr Val Val His
   1               5                  10                  15    
 His Pro Leu Met Val Ser Asp Arg Met Asp Leu Asp Thr Leu Ala Arg
              20                  25                  30        
 Ser Arg Gln Leu Glu Lys Arg Met Ser Glu Glu Met Arg Leu Leu Glu
          35                  40                  45            
 Met Glu Phe Glu Glu Arg Lys Arg Ala Ala Glu Gln Arg Gln Lys Ala
      50                  55                  60                
 Glu Asn Phe Trp Thr Gly Asp Thr Ser Ser Asp Gln Leu Val Leu Gly
  65                  70                  75                  80
 Lys Lys Asp Met Gly Trp Pro Phe Gln Ala Asp Gly Gln Glu Gly Pro
                  85                  90                  95    
 Leu Gly Trp Met Leu Gly Asn Leu Trp Asn Thr Gly Leu Phe Cys Leu
             100                 105                 110        
 Phe Leu Val Phe Glu Leu Leu Arg Gln Asn Met Gln His Glu Pro Ala
         115                 120                 125            
 Phe Asp Ser Ser Ser Glu Glu Glu Glu Glu Glu Val Arg Val Val Pro
     130                 135                 140                
 Val Thr Ser Tyr Asn Trp Leu Thr Asp Phe Pro Ser Gln Glu Ala Leu
 145                 150                 155                 160
 Asp Ser Phe Tyr Lys His Tyr Val Gln Asn Ala Ile Arg Asp Leu Pro
                 165                 170                 175    
 Cys Thr Cys Glu Phe Val Glu Ser Phe Val Asp Asp Leu Ile Glu Ala
             180                 185                 190        
 Cys Arg Val Leu Ser Arg Gln Glu Ala His Pro Gln Leu Glu Asp Cys
         195                 200                 205            
 Leu Gly Ile Gly Ala Ala Phe Glu Lys Trp Gly Thr Leu His Glu Thr
     210                 215                 220                
 Gln Lys Phe Asp Ile Leu Val Pro Ile Val Pro Pro Gln Gly Thr Met
 225                 230                 235                 240
 Phe Val Leu Glu Met Arg Asp Pro Ala Leu Gly Arg Arg Cys Gly Cys
                 245                 250                 255    
 Val Leu Val Glu Ser Glu Cys Val Cys Lys Arg Glu Lys Leu Leu Gly
             260                 265                 270        
 Asp Val Leu Cys Leu Val His His His Arg Asp Pro Ser Ala Val Leu
         275                 280                 285            
 Gly Lys Cys Ser Ser Ser Ile Lys Ala Ala Leu Cys Thr Gly Phe His
     290                 295                 300                
 Leu Asp Val Cys Lys Thr Val Gln Trp Phe Arg Asn Met Met Gly Asn
 305                 310                 315                 320
 Ala Trp Ala Leu Val Ala His Lys Tyr Asp Phe Lys Leu Ser Leu Pro
                 325                 330                 335    
 Pro Ser Thr Thr Ser Cys Lys Leu Arg Leu Asp Tyr Arg Ser Gly Arg
             340                 345                 350        
 Phe Leu Ser Ile His Leu Val Leu Gly Val Gln Arg Glu Asp Thr Leu
         355                 360                 365            
 Val Tyr Leu Val Ser Gln Ala Pro Asp Gln Glu Gln Leu Thr Ser Val
     370                 375                 380                
 Asp Trp Pro Glu Ser Phe Val Ala Cys Glu His Leu Phe Leu Lys Leu
 385                 390                 395                 400
 Val Gly Arg Phe Ala Pro Glu Asn Thr Cys His Leu Lys Cys Leu Gln
                 405                 410                 415    
 Ile Ile Leu Ser Leu Arg Gln His Gln Ser Leu Pro His Gly Ala Ser
             420                 425                 430        
 Arg Pro Ile Leu Thr Ser Tyr His Phe Lys Thr Ala Leu Met His Leu
         435                 440                 445            
 Leu Leu Arg Leu Pro Leu Thr Asp Trp Ala His Asn Met Leu Ser Gln
     450                 455                 460                
 Arg Leu Gln Asp Ile Leu Trp Phe Leu Gly Arg Gly Leu Gln Gln Arg
 465                 470                 475                 480
 Ser Leu His His Phe Leu Ile Gly Asn Asn Phe Leu Pro Leu Thr Ile
                 485                 490                 495    
 Pro Ile Pro Lys Thr Phe Arg Asn Ala Glu Pro Val Asn Leu Phe Gln
             500                 505                 510        
 His Leu Val Leu Asn Pro Lys Ala His Ser Gln Ala Val Glu Glu Phe
         515                 520                 525            
 Gln Asn Leu Leu Thr Gln Val Lys Thr Leu Pro His Ala Pro Leu Ala
     530                 535                 540                
 Ala Ala Pro
 545        



      <210> 302
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 302
 Met Leu Phe Leu Ala Leu Gly Ser Pro Trp Ala Val Glu Leu Pro Leu
   1               5                  10                  15    
 Cys Gly Arg Arg Thr Ala Leu Cys Ala Ala Ala Ala Leu Arg Gly Pro
              20                  25                  30        
 Arg Ala Ser Val Ser Arg Ala Ser Ser Ser Ser Gly Pro Ser Gly Pro
          35                  40                  45            
 Val Ala Gly Trp Ser Thr Gly Pro Ser Gly Ala Ala Arg Leu Leu Arg
      50                  55                  60                
 Arg Pro Gly Arg Ala Gln Ile Pro Val Tyr Trp Glu Gly Tyr Val Arg
  65                  70                  75                  80
 Phe Leu Asn Thr Pro Ser Asp Lys Ser Glu Asp Gly Arg Leu Ile Tyr
                  85                  90                  95    
 Thr Gly Asn Met Ala Arg Ala Val Phe Gly Val Lys Cys Phe Ser Tyr
             100                 105                 110        
 Ser Thr Ser Leu Ile Gly Leu Thr Phe Leu Pro Tyr Ile Phe Thr Gln
         115                 120                 125            
 Asn Asn Ala Ile Ser Glu Ser Val Pro Leu Pro Ile Gln Ile Ile Phe
     130                 135                 140                
 Tyr Gly Ile Met Gly Ser Phe Thr Val Ile Thr Pro Val Leu Leu His
 145                 150                 155                 160
 Phe Ile Thr Lys Gly Tyr Val Ile Arg Leu Tyr His Glu Ala Thr Thr
                 165                 170                 175    
 Asp Thr Tyr Lys Ala Ile Thr Tyr Asn Ala Met Leu Ala Glu Thr Ser
             180                 185                 190        
 Thr Val Phe His Gln Asn Asp Val Lys Ile Pro Asp Ala Lys His Val
         195                 200                 205            
 Phe Thr Thr Phe Tyr Ala Lys Thr Lys Ser Leu Leu Val Asn Pro Val
     210                 215                 220                
 Leu Phe Pro Asn Arg Glu Asp Tyr Ile His Leu Met Gly Tyr Asp Lys
 225                 230                 235                 240
 Glu Glu Phe Ile Leu Tyr Met Glu Glu Thr Ser Glu Glu Lys Arg His
                 245                 250                 255    
 Lys Asp Asp Lys
             260



      <210> 303
      <211> 311
      <212> PRT
      <213> Homo sapiens


      <400> 303
 Met Cys Met Asp Ala Phe Gln Gly Ile Leu Lys Phe Phe Leu Asn Gln
   1               5                  10                  15    
 Lys Thr Val Ile Gly Tyr Ser Phe Met Ala Leu Leu Thr Val Gly Ser
              20                  25                  30        
 Glu Arg Leu Phe Ser Val Val Ala Phe Lys Cys Pro Cys Ser Thr Glu
          35                  40                  45            
 Asn Met Thr Tyr Gly Leu Val Phe Leu Phe Ala Pro Ala Trp Val Leu
      50                  55                  60                
 Leu Ile Leu Gly Phe Phe Leu Asn Asn Arg Ser Trp Arg Leu Phe Thr
  65                  70                  75                  80
 Gly Cys Cys Val Asn Pro Arg Lys Ile Phe Pro Arg Gly His Ser Cys
                  85                  90                  95    
 Arg Phe Phe Tyr Val Leu Gly Gln Ile Thr Leu Ser Ser Leu Val Ala
             100                 105                 110        
 Pro Val Met Trp Leu Ser Val Ala Leu Leu Asn Gly Thr Phe Tyr Glu
         115                 120                 125            
 Cys Ala Met Ser Gly Thr Arg Ser Ser Gly Leu Leu Glu Leu Ile Cys
     130                 135                 140                
 Lys Gly Lys Pro Lys Glu Cys Trp Glu Glu Leu His Lys Val Ser Cys
 145                 150                 155                 160
 Gly Lys Thr Ser Met Leu Pro Thr Val Asn Glu Glu Leu Lys Leu Ser
                 165                 170                 175    
 Leu Gln Ala Gln Ser Gln Ile Leu Gly Trp Cys Leu Ile Cys Ser Ala
             180                 185                 190        
 Ser Phe Phe Ser Leu Leu Thr Thr Cys Tyr Ala Arg Cys Arg Ser Lys
         195                 200                 205            
 Val Ser Tyr Leu Gln Leu Ser Phe Trp Lys Thr Tyr Ala Gln Lys Glu
     210                 215                 220                
 Lys Glu Gln Leu Glu Asn Thr Phe Leu Asp Tyr Ala Asn Lys Leu Ser
 225                 230                 235                 240
 Glu Arg Asn Leu Lys Cys Phe Phe Glu Asn Lys Arg Pro Asp Pro Phe
                 245                 250                 255    
 Pro Met Pro Thr Phe Ala Ala Trp Glu Ala Ala Ser Glu Leu His Ser
             260                 265                 270        
 Phe His Gln Ser Gln Gln His Tyr Ser Thr Leu His Arg Val Val Asp
         275                 280                 285            
 Asn Gly Leu Gln Leu Ser Pro Glu Asp Asp Glu Thr Thr Met Val Leu
     290                 295                 300                
 Val Gly Thr Ala His Asn Met
 305                 310    



      <210> 304
      <211> 99
      <212> PRT
      <213> Homo sapiens


      <400> 304
 Met Glu Ala Val Val Phe Val Phe Ser Leu Leu Asp Cys Cys Ala Leu
   1               5                  10                  15    
 Ile Phe Leu Ser Val Tyr Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys
              20                  25                  30        
 Asp Tyr Ile Asn Ala Arg Ser Cys Cys Ser Lys Leu Asn Lys Trp Val
          35                  40                  45            
 Ile Pro Glu Leu Ile Gly His Thr Ile Val Thr Val Leu Leu Leu Met
      50                  55                  60                
 Ser Leu His Trp Phe Ile Phe Leu Leu Asn Leu Pro Val Ala Thr Trp
  65                  70                  75                  80
 Asn Ile Tyr Arg Tyr Ile Met Val Pro Ser Gly Asn Lys Tyr Thr Ile
                  85                  90                  95    
 Glu Gly Ser
            



      <210> 305
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 305
 Met Leu Trp Thr Leu Leu Ser Ile Val Val Ala Phe Ala Glu Leu Ile
   1               5                  10                  15    
 Ala Phe Met Ser Ala Asp Trp Leu Ile Gly Lys Ala Arg Ser Arg Gly
              20                  25                  30        
 Gly Val Glu Pro Ala Gly Pro Gly Gly Gly Ser Pro Glu Pro Tyr His
          35                  40                  45            
 Pro Thr Leu Gly Ile Tyr Ala Arg Cys Ile Arg Asn Pro Gly Val Gln
      50                  55                  60                
 His Phe Gln Arg Asp Thr Leu Cys Gly Pro Tyr Ala Glu Ser Phe Gly
  65                  70                  75                  80
 Glu Ile Ala Ser Gly Phe Trp Gln Ala Thr Ala Ile Phe Leu Ala Val
                  85                  90                  95    
 Gly Ile Phe Ile Leu Cys Met Val Ala Leu Val Ser Val Phe Thr Met
             100                 105                 110        
 Cys Val Gln Ser Ile Met Lys Lys Ser Ile Phe Asn Val Cys Gly Leu
         115                 120                 125            
 Leu Gln Gly Ile Ala Gly Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr
     130                 135                 140                
 Pro Ala Gly Trp Gly Cys Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr
 145                 150                 155                 160
 Ala Ser Ala Tyr Lys Pro Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr
                 165                 170                 175    
 Thr Ala Ile Gly Gly Thr Val Leu Thr Phe Ile Cys Ala Val Phe Ser
             180                 185                 190        
 Ala Gln Ala Glu Ile Ala Thr Ser Ser Asp Lys Val Gln Glu Glu Ile
         195                 200                 205            
 Glu Glu Gly Lys Asn Leu Ile Cys Leu Leu
     210                 215            



      <210> 306
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 306
 Met Val Ser Trp Lys Gly Ile Tyr Phe Ile Leu Thr Leu Phe Trp Gly
   1               5                  10                  15    
 Ser Phe Phe Gly Ser Ile Phe Met Leu Ser Pro Phe Leu Pro Leu Met
              20                  25                  30        
 Phe Val Asn Pro Ser Trp Tyr Arg Trp Ile Asn Asn Arg Leu Val Ala
          35                  40                  45            
 Thr Trp Leu Thr Leu Pro Val Ala Leu Leu Glu Thr Met Phe Gly Val
      50                  55                  60                
 Lys Val Ile Ile Thr Gly Asp Ala Phe Val Pro Gly Glu Arg Ser Val
  65                  70                  75                  80
 Ile Ile Met Asn His Arg Thr Arg Met Asp Trp Met Phe Leu Trp Asn
                  85                  90                  95    
 Cys Leu Met Arg Tyr Ser Tyr Leu Arg Leu Glu Lys Ile Cys Leu Lys
             100                 105                 110        
 Ala Ser Leu Lys Gly Val Pro Gly Trp Ala Met Gln Ala Ala Ala Tyr
         115                 120                 125            
 Ile Phe Ile His Arg Lys Trp Lys Asp Asp Lys Ser His Phe Glu Asp
     130                 135                 140                
 Met Ile Asp Tyr Phe Cys Asp Ile His Glu Pro Leu Gln Leu Leu Ile
 145                 150                 155                 160
 Phe Pro Glu Gly Thr Asp Leu Thr Glu Asn Ser Lys Ser Arg Ser Asn
                 165                 170                 175    
 Ala Phe Ala Glu Lys Asn Gly Leu Gln Lys Tyr Glu Tyr Val Leu His
             180                 185                 190        
 Pro Arg Thr Thr Gly Phe Thr Phe Val Val Asp Arg Leu Arg Glu Gly
         195                 200                 205            
 Lys His Pro Phe Gln Asn Val Leu Phe Asn Lys Ser Gly Lys Ser Arg
     210                 215                 220                
 Arg Gly Pro Phe Cys Lys Arg
 225                 230    



      <210> 307
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 307
 Met Gly Tyr Cys Ser Gly Arg Cys Thr Leu Ile Phe Ile Cys Gly Met
   1               5                  10                  15    
 Gln Leu Val Cys Val Leu Glu Arg Gln Ile Phe Asp Phe Leu Gly Tyr
              20                  25                  30        
 Gln Trp Ala Pro Ile Leu Ala Asn Phe Val His Ile Ile Ile Val Ile
          35                  40                  45            
 Leu Gly Leu Phe Gly Thr Ile Gln Tyr Arg Pro Arg Tyr Ile Thr Gly
      50                  55                  60                
 Tyr Ala Val Trp Leu Val Leu Trp Val Thr Trp Asn Val Phe Val Ile
  65                  70                  75                  80
 Cys Phe Tyr Leu Glu Ala Gly Asp Leu Ser Lys Glu Thr Asp Leu Ile
                  85                  90                  95    
 Leu Thr Phe Asn Ile Ser Met His Arg Ser Trp Trp Met Glu Asn Gly
             100                 105                 110        
 Pro Gly Cys Thr Val Thr Ser Val Thr Pro Ala Pro Asp Trp Ala Pro
         115                 120                 125            
 Glu Asp His Arg Tyr Ile Thr Val Ser Gly Cys Leu Leu Glu Tyr Gln
     130                 135                 140                
 Tyr Ile Glu Val Ala His Ser Ser Leu Gln Ile Val Leu Ala Ala Leu
 145                 150                 155                 160
 Arg Val Ile Ser Phe Leu Arg Leu Gln Asp Gln Ala Phe His Thr Thr
                 165                 170                 175    
 Ser Leu Leu Ser Asp Asn Glu Ser Val Tyr Leu Tyr Cys Ala Tyr Arg
             180                 185                 190        
 Thr Ser Gln
         195



      <210> 308
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 308
 Met Arg Ser Ser Leu Ala Pro Gly Val Trp Phe Phe Arg Ala Phe Ser
   1               5                  10                  15    
 Arg Asp Ser Trp Phe Arg Gly Leu Ile Leu Leu Leu Thr Phe Leu Ile
              20                  25                  30        
 Tyr Ala Cys Tyr His Met Ser Arg Lys Pro Ile Ser Ile Val Lys Ser
          35                  40                  45            
 Arg Leu His Gln Asn Cys Ser Glu Gln Ile Lys Pro Ile Asn Asp Thr
      50                  55                  60                
 His Ser Leu Asn Asp Thr Met Trp Cys Ser Trp Ala Pro Phe Asp Lys
  65                  70                  75                  80
 Asp Asn Tyr Lys Glu Leu Leu Gly Gly Val Asp Asn Ala Phe Leu Ile
                  85                  90                  95    
 Ala Tyr Ala Ile Gly Met Phe Ile Ser Gly Val Phe Gly Glu Arg Leu
             100                 105                 110        
 Pro Leu Arg Tyr Tyr Leu Ser Ala Gly Met Leu Leu Ser Gly Leu Phe
         115                 120                 125            
 Thr Ser Leu Phe Gly Leu Gly Tyr Phe Trp Asn Ile His Glu Leu Trp
     130                 135                 140                
 Tyr Phe Val Val Ile Gln Val Cys Asn Gly Leu Val Gln Thr Thr Gly
 145                 150                 155                 160
 Trp Pro Ser Val Val Thr Cys Val Gly Asn Trp Phe Gly Lys Gly Lys
                 165                 170                 175    
 Arg Gly Phe Ile Met Gly Ile Trp Asn Ser His Thr Ser Val Gly Asn
             180                 185                 190        
 Ile Leu Gly Ser Leu Ile Ala Gly Ile Trp Val Asn Gly Gln Trp Gly
         195                 200                 205            
 Leu Ser Phe Ile Val Pro Gly Ile Ile Thr Ala Val Met Gly Val Ile
     210                 215                 220                
 Thr Phe Leu Phe Leu Ile Glu His Pro Glu Asp Val Asp Cys Ala Pro
 225                 230                 235                 240
 Pro Gln His His Gly Glu Pro Ala Glu Asn Gln Asp Asn Pro Glu Asp
                 245                 250                 255    
 Pro Gly Asn Ser Pro Cys Ser Ile Arg Glu Ser Gly Leu Glu Thr Val
             260                 265                 270        
 Ala Lys Cys Ser Lys Gly Pro Cys Glu Glu Pro Ala Ala Ile Ser Phe
         275                 280                 285            
 Phe Gly Ala Leu Arg Ile Pro Gly Val Val Glu Phe Ser Leu Cys Leu
     290                 295                 300                
 Leu Phe Ala Lys Leu Val Ser Tyr Thr Phe Leu Tyr Trp Leu Pro Leu
 305                 310                 315                 320
 Tyr Ile Ala Asn Val Ala His Phe Ser Ala Lys Glu Ala Gly Asp Leu
                 325                 330                 335    
 Ser Thr Leu Phe Asp Val Gly Gly Ile Ile Gly Gly Ile Val Ala Gly
             340                 345                 350        
 Leu Val Ser Asp Tyr Thr Asn Gly Arg Ala Thr Thr Cys Cys Val Met
         355                 360                 365            
 Leu Ile Leu Ala Ala Pro Met Met Phe Leu Tyr Asn Tyr Ile Gly Gln
     370                 375                 380                
 Asp Gly Ile Ala Ser Ser Ile Val Met Leu Ile Ile Cys Gly Gly Leu
 385                 390                 395                 400
 Val Asn Gly Pro Tyr Ala Leu Ile Thr Thr Ala Val Ser Ala Asp Leu
                 405                 410                 415    
 Gly Thr His Lys Ser Leu Lys Gly Asn Ala Lys Ala Leu Ser Thr Val
             420                 425                 430        
 Thr Ala Ile Ile Asp Gly Thr Gly Ser Ile Gly Ala Ala Leu Gly Pro
         435                 440                 445            
 Leu Leu Ala Gly Leu Ile Ser Pro Thr Gly Trp Asn Asn Val Phe Tyr
     450                 455                 460                
 Met Leu Ile Ser Ala Asp Val Leu Ala Cys Leu Leu Leu Cys Arg Leu
 465                 470                 475                 480
 Val Tyr Lys Glu Ile Leu Ala Trp Lys Val Ser Leu Ser Arg Gly Ser
                 485                 490                 495    
 Gly Tyr Lys Glu Ile
             500    



      <210> 309
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 309
 Met Gly Glu Glu Asn Gln Thr Phe Val Ser Lys Phe Ile Phe Leu Gly
   1               5                  10                  15    
 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Ile Leu Phe Leu
              20                  25                  30        
 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Gln Leu Ile Ile Ile Leu
          35                  40                  45            
 Ile Phe Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg
      50                  55                  60                
 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln
  65                  70                  75                  80
 Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Tyr Gly
                  85                  90                  95    
 Cys Met Thr Gln Ile Ile Val Phe Leu Leu Val Gly Cys Thr Glu Cys
             100                 105                 110        
 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys
         115                 120                 125            
 Pro Leu Tyr Tyr Ser Thr Ile Met Thr Gln Arg Val Cys Leu Trp Leu
     130                 135                 140                
 Ser Phe Arg Ser Cys Gln His His Gln His Arg Thr Leu Leu Pro Glu
 145                 150                 155                 160
 Leu Leu Ile Leu Glu Thr Glu Tyr Cys Cys Ile His Cys His Val Ser
                 165                 170                 175    
 Pro Phe Thr Gly Pro Glu Phe Gln Val Cys Gly Val Gly Gly Ala Cys
             180                 185                 190        
 Arg Lys Gly Arg Gly Trp Gln Arg Pro Gly Leu Pro His Arg Ser Gly
         195                 200                 205            
 Ser Arg Gly Leu Leu Gly Gly Ser Phe His Ser Trp Cys Ala Cys Ala
     210                 215                 220                
 Arg Val Arg Arg Gly Cys Ser Ala Ala Ile Tyr Glu Thr Arg Ser Arg
 225                 230                 235                 240
 Gln
    



      <210> 310
      <211> 71
      <212> PRT
      <213> Homo sapiens


      <400> 310
 Met Leu Phe Lys Leu Leu Gln Arg Gln Thr Tyr Thr Cys Leu Ser His
   1               5                  10                  15    
 Arg Tyr Gly Leu Tyr Val Cys Phe Leu Gly Val Val Val Thr Ile Val
              20                  25                  30        
 Ser Ala Phe Gln Phe Gly Glu Val Val Leu Glu Trp Ser Arg Asp Gln
          35                  40                  45            
 Tyr His Val Leu Phe Asp Ser Tyr Arg Asp Asn Ile Ala Gly Lys Ser
      50                  55                  60                
 Phe Gln Asn Arg Ser Val Arg
  65                  70    



      <210> 311
      <211> 450
      <212> PRT
      <213> Homo sapiens


      <400> 311
 Met Gly Leu Arg Ser His His Leu Ser Leu Gly Leu Leu Leu Leu Phe
   1               5                  10                  15    
 Leu Leu Pro Ala Glu Cys Leu Gly Ala Glu Gly Arg Leu Ala Leu Lys
              20                  25                  30        
 Leu Phe Arg Asp Leu Phe Ala Asn Tyr Thr Ser Ala Leu Arg Pro Val
          35                  40                  45            
 Ala Asp Thr Asp Gln Thr Leu Asn Val Thr Leu Glu Val Thr Leu Ser
      50                  55                  60                
 Gln Ile Ile Asp Met Asp Glu Arg Asn Gln Val Leu Thr Leu Tyr Leu
  65                  70                  75                  80
 Trp Ile Arg Gln Glu Trp Thr Asp Ala Tyr Leu Arg Trp Asp Pro Asn
                  85                  90                  95    
 Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro Ser Ser Leu Val Trp
             100                 105                 110        
 Arg Pro Asp Ile Val Leu Tyr Asn Lys Ala Asp Ala Gln Pro Pro Gly
         115                 120                 125            
 Ser Ala Ser Thr Asn Val Val Leu Arg His Asp Gly Ala Val Arg Trp
     130                 135                 140                
 Asp Ala Pro Ala Ile Thr Arg Ser Ser Cys Arg Val Asp Val Ala Ala
 145                 150                 155                 160
 Phe Pro Phe Asp Ala Gln His Cys Gly Leu Thr Phe Gly Ser Trp Thr
                 165                 170                 175    
 His Gly Gly His Gln Leu Asp Val Arg Pro Arg Gly Ala Ala Ala Ser
             180                 185                 190        
 Leu Ala Asp Phe Val Glu Asn Val Glu Trp Arg Val Leu Gly Met Pro
         195                 200                 205            
 Ala Arg Arg Arg Val Leu Thr Tyr Gly Cys Cys Ser Glu Pro Tyr Pro
     210                 215                 220                
 Asp Val Thr Phe Thr Leu Leu Leu Arg Arg Arg Ala Ala Ala Tyr Val
 225                 230                 235                 240
 Cys Asn Leu Leu Leu Pro Cys Val Leu Ile Ser Leu Leu Ala Pro Leu
                 245                 250                 255    
 Ala Phe His Leu Pro Ala Asp Ser Gly Glu Lys Val Ser Leu Gly Val
             260                 265                 270        
 Thr Val Leu Leu Ala Leu Thr Val Phe Gln Leu Leu Leu Ala Glu Ser
         275                 280                 285            
 Met Pro Pro Ala Glu Ser Val Pro Leu Ile Gly Lys Tyr Tyr Met Ala
     290                 295                 300                
 Thr Met Thr Met Val Thr Phe Ser Thr Ala Leu Thr Ile Leu Ile Met
 305                 310                 315                 320
 Asn Leu His Tyr Cys Gly Pro Ser Val Arg Pro Val Pro Ala Trp Ala
                 325                 330                 335    
 Arg Ala Leu Leu Leu Gly His Leu Ala Arg Gly Leu Cys Val Arg Glu
             340                 345                 350        
 Arg Gly Glu Pro Cys Gly Gln Ser Arg Pro Pro Glu Leu Ser Pro Ser
         355                 360                 365            
 Pro Gln Ser Pro Glu Gly Gly Ala Gly Pro Pro Ala Gly Pro Cys His
     370                 375                 380                
 Glu Pro Arg Cys Leu Cys Arg Gln Glu Ala Leu Leu His His Val Ala
 385                 390                 395                 400
 Thr Ile Ala Asn Thr Phe Arg Ser His Arg Ala Ala Gln Arg Cys His
                 405                 410                 415    
 Glu Asp Trp Lys Arg Leu Ala Arg Val Met Asp Arg Phe Phe Leu Ala
             420                 425                 430        
 Ile Phe Phe Ser Met Ala Leu Val Met Ser Leu Leu Val Leu Val Gln
         435                 440                 445            
 Ala Leu
     450



      <210> 312
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 312
 Met Gly Arg Ala Arg Arg Phe Gln Trp Pro Leu Leu Leu Leu Trp Ala
   1               5                  10                  15    
 Ala Ala Ala Gly Pro Gly Ala Gly Gln Glu Val Gln Thr Glu Asn Val
              20                  25                  30        
 Thr Val Ala Glu Gly Gly Val Ala Glu Ile Thr Cys Arg Leu His Gln
          35                  40                  45            
 Tyr Asp Gly Ser Ile Val Val Ile Gln Asn Pro Ala Arg Gln Thr Leu
      50                  55                  60                
 Phe Phe Asn Gly Thr Arg Ala Leu Lys Asp Glu Arg Phe Gln Leu Glu
  65                  70                  75                  80
 Glu Phe Ser Pro Arg Arg Val Arg Ile Arg Leu Ser Asp Ala Arg Leu
                  85                  90                  95    
 Glu Asp Glu Gly Gly Tyr Phe Cys Gln Leu Tyr Thr Glu Asp Thr His
             100                 105                 110        
 His Gln Ile Ala Thr Leu Thr Val Leu Val Ala Pro Glu Asn Pro Val
         115                 120                 125            
 Val Glu Val Arg Glu Gln Ala Val Glu Gly Gly Glu Val Glu Leu Ser
     130                 135                 140                
 Cys Leu Val Pro Arg Ser Arg Pro Ala Ala Thr Leu Arg Trp Tyr Arg
 145                 150                 155                 160
 Asp Arg Lys Glu Leu Lys Val Ser Asp Arg Gly Val Ala Gly Val Ser
                 165                 170                 175    
 Ser Ser Gln Glu Asn Gly Lys Val Trp Ser Val Ala Ser Thr Val Arg
             180                 185                 190        
 Phe Arg Val Asp Arg Lys Asp Asp Gly Gly Ile Ile Ile Cys Glu Ala
         195                 200                 205            
 Gln Asn Gln Ala Leu Pro Ser Gly His Ser Lys Gln Thr Gln Tyr Val
     210                 215                 220                
 Leu Asp Val Gln Tyr Ser Pro Thr Ala Arg Ile His Ala Ser Gln Ala
 225                 230                 235                 240
 Val Val Arg Glu Gly Asp Thr Leu Val Leu Thr Cys Ala Val Thr Gly
                 245                 250                 255    
 Asn Pro Arg Pro Asn Gln Ile Arg Trp Asn Arg Gly Asn Glu Ser Leu
             260                 265                 270        
 Pro Glu Arg Ala Glu Ala Val Gly Glu Thr Leu Thr Leu Pro Gly Leu
         275                 280                 285            
 Val Ser Ala Asp Asn Gly Thr Tyr Thr Cys Glu Ala Ser Asn Lys His
     290                 295                 300                
 Gly His Ala Arg Ala Leu Tyr Val Leu Val Val Tyr Asp Pro Gly Ala
 305                 310                 315                 320
 Val Val Glu Ala Gln Thr Ser Val Pro Tyr Ala Ile Val Gly Gly Ile
                 325                 330                 335    
 Leu Ala Leu Leu Val Phe Leu Ile Ile Cys Val Leu Val Gly Met Val
             340                 345                 350        
 Trp Cys Ser Val Arg Gln Lys Gly Ser Tyr Leu Thr His Glu Ala Ser
         355                 360                 365            
 Gly Leu Asp Glu Gln Gly Glu Val Arg Glu Ala Phe Leu Asn Gly Ser
     370                 375                 380                
 Asp Gly His Lys Arg Lys Glu Glu Phe Phe Ile
 385                 390                 395



      <210> 313
      <211> 771
      <212> PRT
      <213> Homo sapiens


      <400> 313
 Met Ala Pro Gly Pro Phe Ser Ser Ala Leu Leu Ser Pro Pro Pro Ala
   1               5                  10                  15    
 Ala Leu Pro Phe Leu Leu Leu Leu Trp Ala Gly Ala Ser Arg Gly Gln
              20                  25                  30        
 Pro Cys Pro Gly Arg Cys Ile Cys Gln Asn Val Ala Pro Thr Leu Thr
          35                  40                  45            
 Met Leu Cys Ala Lys Thr Gly Leu Leu Phe Val Pro Pro Ala Ile Asp
      50                  55                  60                
 Arg Arg Val Val Glu Leu Arg Leu Thr Asp Asn Phe Ile Ala Ala Val
  65                  70                  75                  80
 Arg Arg Arg Asp Phe Ala Asn Met Thr Ser Leu Val His Leu Thr Leu
                  85                  90                  95    
 Ser Arg Asn Thr Ile Gly Gln Val Ala Ala Gly Ala Phe Ala Asp Leu
             100                 105                 110        
 Arg Ala Leu Arg Ala Leu His Leu Asp Ser Asn Arg Leu Ala Glu Val
         115                 120                 125            
 Arg Gly Asp Gln Leu Arg Gly Leu Gly Asn Leu Arg His Leu Ile Leu
     130                 135                 140                
 Gly Asn Asn Gln Ile Arg Arg Val Glu Ser Ala Ala Phe Asp Ala Phe
 145                 150                 155                 160
 Leu Ser Thr Val Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Glu Ala
                 165                 170                 175    
 Leu Pro Trp Glu Ala Val Gly Gln Met Val Asn Leu Asn Thr Leu Thr
             180                 185                 190        
 Leu Asp His Asn Leu Ile Asp His Ile Ala Glu Gly Thr Phe Val Gln
         195                 200                 205            
 Leu His Lys Leu Val Arg Leu Asp Met Thr Ser Asn Arg Leu His Lys
     210                 215                 220                
 Leu Pro Pro Asp Gly Leu Phe Leu Arg Ser Gln Gly Thr Gly Pro Lys
 225                 230                 235                 240
 Pro Pro Thr Pro Leu Thr Val Ser Phe Gly Gly Asn Pro Leu His Cys
                 245                 250                 255    
 Asn Cys Glu Leu Leu Trp Leu Arg Arg Leu Thr Arg Glu Asp Asp Leu
             260                 265                 270        
 Glu Thr Cys Ala Thr Pro Glu His Leu Thr Asp Arg Tyr Phe Trp Ser
         275                 280                 285            
 Ile Pro Glu Glu Glu Phe Leu Cys Glu Pro Pro Leu Ile Thr Arg Gln
     290                 295                 300                
 Ala Gly Gly Arg Ala Leu Val Val Glu Gly Gln Ala Val Ser Leu Arg
 305                 310                 315                 320
 Cys Arg Ala Val Gly Asp Pro Glu Pro Val Val His Trp Val Ala Pro
                 325                 330                 335    
 Asp Gly Arg Leu Leu Gly Asn Ser Ser Arg Thr Arg Val Arg Gly Asp
             340                 345                 350        
 Gly Thr Leu Asp Val Thr Ile Thr Thr Leu Arg Asp Ser Gly Thr Phe
         355                 360                 365            
 Thr Cys Ile Ala Ser Asn Ala Ala Gly Glu Ala Thr Ala Pro Val Glu
     370                 375                 380                
 Val Cys Val Val Pro Leu Pro Leu Met Ala Pro Pro Pro Ala Ala Pro
 385                 390                 395                 400
 Pro Pro Leu Thr Glu Pro Gly Ser Ser Asp Ile Ala Thr Pro Gly Arg
                 405                 410                 415    
 Pro Gly Ala Asn Asp Ser Ala Ala Glu Arg Arg Leu Val Ala Ala Glu
             420                 425                 430        
 Leu Thr Ser Asn Ser Val Leu Ile Arg Trp Pro Ala Gln Arg Pro Val
         435                 440                 445            
 Pro Gly Ile Arg Met Tyr Gln Val Gln Tyr Asn Ser Ser Val Asp Asp
     450                 455                 460                
 Ser Leu Val Tyr Arg Met Ile Pro Ser Thr Ser Gln Thr Phe Leu Val
 465                 470                 475                 480
 Asn Asp Leu Ala Ala Gly Arg Ala Tyr Asp Leu Cys Val Leu Ala Val
                 485                 490                 495    
 Tyr Asp Asp Gly Ala Thr Ala Leu Pro Ala Thr Arg Val Val Gly Cys
             500                 505                 510        
 Val Gln Phe Thr Thr Ala Gly Asp Pro Ala Pro Cys Arg Pro Leu Arg
         515                 520                 525            
 Ala His Phe Leu Gly Gly Thr Met Ile Ile Ala Ile Gly Gly Val Ile
     530                 535                 540                
 Val Ala Ser Val Leu Val Phe Ile Val Leu Leu Met Ile Arg Tyr Lys
 545                 550                 555                 560
 Val Tyr Gly Asp Gly Asp Ser Arg Arg Val Lys Gly Ser Arg Ser Leu
                 565                 570                 575    
 Pro Arg Val Ser His Val Cys Ser Gln Thr Asn Gly Ala Gly Thr Gly
             580                 585                 590        
 Ala Ala Gln Ala Pro Ala Leu Pro Ala Gln Asp His Tyr Glu Ala Leu
         595                 600                 605            
 Arg Glu Val Glu Ser Gln Ala Ala Pro Ala Val Ala Val Glu Ala Lys
     610                 615                 620                
 Ala Met Glu Ala Glu Thr Ala Ser Ala Glu Pro Glu Val Val Leu Gly
 625                 630                 635                 640
 Arg Ser Leu Gly Gly Ser Ala Thr Ser Leu Cys Leu Leu Pro Ser Glu
                 645                 650                 655    
 Glu Thr Ser Gly Glu Glu Ser Arg Ala Ala Val Gly Pro Arg Arg Ser
             660                 665                 670        
 Arg Ser Gly Ala Leu Glu Pro Pro Thr Ser Ala Pro Pro Thr Leu Ala
         675                 680                 685            
 Leu Val Pro Gly Gly Ala Ala Ala Arg Pro Arg Pro Gln Gln Arg Tyr
     690                 695                 700                
 Ser Phe Asp Gly Asp Tyr Gly Ala Leu Phe Gln Ser His Ser Tyr Pro
 705                 710                 715                 720
 Arg Arg Ala Arg Arg Thr Lys Arg His Arg Ser Thr Pro His Leu Asp
                 725                 730                 735    
 Gly Ala Gly Gly Gly Ala Ala Gly Glu Asp Gly Asp Leu Gly Leu Gly
             740                 745                 750        
 Ser Ala Arg Ala Cys Leu Ala Phe Thr Ser Thr Glu Trp Met Leu Glu
         755                 760                 765            
 Ser Thr Val
     770    



      <210> 314
      <211> 500
      <212> PRT
      <213> Homo sapiens


      <400> 314
 Met Arg Gly Glu Leu Trp Leu Leu Val Leu Val Leu Arg Glu Ala Ala
   1               5                  10                  15    
 Arg Ala Leu Ser Pro Gln Pro Gly Ala Gly His Asp Glu Gly Pro Gly
              20                  25                  30        
 Ser Gly Trp Ala Ala Lys Gly Thr Val Arg Gly Trp Asn Arg Arg Ala
          35                  40                  45            
 Arg Glu Ser Pro Gly His Val Ser Glu Pro Asp Arg Thr Gln Leu Ser
      50                  55                  60                
 Gln Asp Leu Gly Gly Gly Thr Leu Ala Met Asp Thr Leu Pro Asp Asn
  65                  70                  75                  80
 Arg Thr Arg Val Val Glu Asp Asn His Ser Tyr Tyr Val Ser Arg Leu
                  85                  90                  95    
 Tyr Gly Pro Ser Glu Pro His Ser Arg Glu Leu Trp Val Asp Val Ala
             100                 105                 110        
 Glu Ala Asn Arg Ser Gln Val Lys Ile His Thr Ile Leu Ser Asn Thr
         115                 120                 125            
 His Arg Gln Ala Ser Arg Val Val Leu Ser Phe Asp Phe Pro Phe Tyr
     130                 135                 140                
 Gly His Pro Leu Arg Gln Ile Thr Ile Ala Thr Gly Gly Phe Ile Phe
 145                 150                 155                 160
 Met Gly Asp Val Ile His Arg Met Leu Thr Ala Thr Gln Tyr Val Ala
                 165                 170                 175    
 Pro Leu Met Ala Asn Phe Asn Pro Gly Tyr Ser Asp Asn Ser Thr Val
             180                 185                 190        
 Val Tyr Phe Asp Asn Gly Thr Val Phe Val Val Gln Trp Asp His Val
         195                 200                 205            
 Tyr Leu Gln Gly Trp Glu Asp Lys Gly Ser Phe Thr Phe Gln Ala Ala
     210                 215                 220                
 Leu His His Asp Gly Arg Ile Val Phe Ala Tyr Lys Glu Ile Pro Met
 225                 230                 235                 240
 Ser Val Pro Glu Ile Ser Ser Ser Gln His Pro Val Lys Thr Gly Leu
                 245                 250                 255    
 Ser Asp Ala Phe Met Ile Leu Asn Pro Ser Pro Asp Val Pro Glu Ser
             260                 265                 270        
 Arg Arg Arg Ser Ile Phe Glu Tyr His Arg Ile Glu Leu Asp Pro Ser
         275                 280                 285            
 Lys Val Thr Ser Met Ser Ala Val Glu Phe Thr Pro Leu Pro Thr Cys
     290                 295                 300                
 Leu Gln His Arg Ser Cys Asp Ala Cys Met Ser Ser Asp Leu Thr Phe
 305                 310                 315                 320
 Asn Cys Ser Trp Cys His Val Leu Gln Arg Cys Ser Ser Gly Phe Asp
                 325                 330                 335    
 Arg Tyr Arg Gln Glu Trp Met Asp Tyr Gly Cys Ala Gln Glu Ala Glu
             340                 345                 350        
 Gly Arg Met Cys Glu Asp Phe Gln Asp Glu Asp His Asp Ser Ala Ser
         355                 360                 365            
 Pro Asp Thr Ser Phe Ser Pro Tyr Asp Gly Asp Leu Thr Thr Thr Ser
     370                 375                 380                
 Ser Ser Leu Phe Ile Asp Ser Leu Thr Thr Glu Asp Asp Thr Lys Leu
 385                 390                 395                 400
 Asn Pro Tyr Ala Gly Gly Asp Gly Leu Gln Asn Asn Leu Ser Pro Lys
                 405                 410                 415    
 Thr Lys Gly Thr Pro Val His Leu Gly Thr Ile Val Gly Ile Val Leu
             420                 425                 430        
 Ala Val Leu Leu Val Ala Ala Ile Ile Leu Ala Gly Ile Tyr Ile Asn
         435                 440                 445            
 Gly His Pro Thr Ser Asn Ala Ala Leu Phe Phe Ile Glu Arg Arg Pro
     450                 455                 460                
 His His Trp Pro Ala Met Lys Phe Arg Ser His Pro Asp His Ser Thr
 465                 470                 475                 480
 Tyr Ala Glu Val Glu Pro Ser Gly His Glu Lys Glu Gly Phe Met Glu
                 485                 490                 495    
 Ala Glu Gln Cys
             500



      <210> 315
      <211> 488
      <212> PRT
      <213> Homo sapiens


      <400> 315
 Met Arg Gly Glu Leu Trp Leu Leu Val Leu Val Leu Arg Glu Ala Ala
   1               5                  10                  15    
 Arg Ala Leu Ser Pro Gln Pro Gly Ala Gly His Asp Glu Gly Pro Gly
              20                  25                  30        
 Ser Gly Trp Ala Ala Lys Gly Thr Val Arg Gly Trp Asn Arg Arg Ala
          35                  40                  45            
 Arg Glu Ser Pro Gly His Val Ser Glu Pro Asp Arg Thr Gln Leu Ser
      50                  55                  60                
 Gln Asp Leu Gly Gly Gly Thr Leu Ala Met Asp Thr Leu Pro Asp Asn
  65                  70                  75                  80
 Arg Thr Arg Val Val Glu Asp Asn His Ser Tyr Tyr Val Ser Arg Leu
                  85                  90                  95    
 Tyr Gly Pro Ser Glu Pro His Ser Arg Glu Leu Trp Val Asp Val Ala
             100                 105                 110        
 Glu Ala Asn Arg Ser Gln Val Lys Ile His Thr Ile Leu Ser Asn Thr
         115                 120                 125            
 His Arg Gln Ala Ser Arg Val Val Leu Ser Phe Asp Phe Pro Phe Tyr
     130                 135                 140                
 Gly His Pro Leu Arg Gln Ile Thr Ile Ala Thr Gly Gly Phe Ile Phe
 145                 150                 155                 160
 Met Gly Asp Val Ile His Arg Met Leu Thr Ala Thr Gln Tyr Val Ala
                 165                 170                 175    
 Pro Leu Met Ala Asn Phe Asn Pro Gly Tyr Ser Asp Asn Ser Thr Val
             180                 185                 190        
 Val Tyr Phe Asp Asn Gly Thr Val Phe Val Val Gln Trp Asp His Val
         195                 200                 205            
 Tyr Leu Gln Gly Trp Glu Asp Lys Gly Ser Phe Thr Phe Gln Ala Ala
     210                 215                 220                
 Leu His His Asp Gly Arg Ile Val Phe Ala Tyr Lys Glu Ile Pro Met
 225                 230                 235                 240
 Ser Val Pro Glu Ile Ser Ser Ser Gln His Pro Val Lys Thr Gly Leu
                 245                 250                 255    
 Ser Asp Ala Phe Met Ile Leu Asn Pro Ser Pro Asp Val Pro Glu Ser
             260                 265                 270        
 Arg Arg Arg Ser Ile Phe Glu Tyr His Arg Ile Glu Leu Asp Pro Ser
         275                 280                 285            
 Lys Val Thr Ser Met Ser Ala Val Glu Phe Thr Pro Leu Pro Thr Cys
     290                 295                 300                
 Leu Gln His Arg Ser Cys Asp Ala Cys Met Ser Ser Asp Leu Thr Phe
 305                 310                 315                 320
 Asn Cys Ser Trp Cys His Val Leu Gln Arg Cys Ser Ser Gly Phe Asp
                 325                 330                 335    
 Arg Tyr Arg Gln Glu Trp Met Asp Tyr Gly Cys Ala Gln Glu Ala Glu
             340                 345                 350        
 Gly Arg Met Cys Glu Asp Phe Gln Asp Glu Asp His Asp Ser Ala Ser
         355                 360                 365            
 Pro Asp Thr Ser Phe Ser Pro Tyr Asp Gly Asp Leu Thr Thr Thr Ser
     370                 375                 380                
 Ser Ser Leu Phe Ile Asp Ser Leu Thr Thr Glu Gly Leu Gln Asn Asn
 385                 390                 395                 400
 Leu Ser Pro Lys Thr Lys Gly Thr Pro Val His Leu Gly Thr Ile Val
                 405                 410                 415    
 Gly Ile Val Leu Ala Val Leu Leu Val Ala Ala Ile Ile Leu Ala Gly
             420                 425                 430        
 Ile Tyr Ile Asn Gly His Pro Thr Ser Asn Ala Ala Leu Phe Phe Ile
         435                 440                 445            
 Glu Arg Arg Pro His His Trp Pro Ala Met Lys Phe Arg Ser His Pro
     450                 455                 460                
 Asp His Ser Thr Tyr Ala Glu Val Glu Pro Ser Gly His Glu Lys Glu
 465                 470                 475                 480
 Gly Phe Met Glu Ala Glu Gln Cys
                 485            



      <210> 316
      <211> 286
      <212> PRT
      <213> Homo sapiens


      <400> 316
 Met Gly Ala Ile Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe
   1               5                  10                  15    
 Phe Leu Cys Gly Leu Ser Phe Ser Glu Thr Cys Thr Thr Val Val Val
              20                  25                  30        
 Ile Pro Arg Met Leu Val Asp Phe Leu Ser Glu Ser Lys Thr Ile Ser
          35                  40                  45            
 Leu Pro Glu Cys Ala Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Ser
      50                  55                  60                
 Asn Asn Cys Phe Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala
  65                  70                  75                  80
 Ile His Asn Pro Leu Gln Tyr His Thr Leu Met Thr Arg Lys Ile Cys
                  85                  90                  95    
 Leu Gln Met Met Met Ala Ser Trp Met Val Gly Phe Leu Phe Ser Leu
             100                 105                 110        
 Cys Ile Ile Val Thr Val Phe Asn Leu Ser Leu Cys Asp Leu Asn Thr
         115                 120                 125            
 Ile Gln His Tyr Phe Cys Asp Ile Ser Pro Val Val Ser Leu Ala Cys
     130                 135                 140                
 Asn Tyr Thr Phe Tyr His Glu Met Ala Ile Phe Val Leu Ser Ala Phe
 145                 150                 155                 160
 Val Leu Val Gly Ser Cys Ile Leu Ile Met Ile Ser Tyr Val Phe Ile
                 165                 170                 175    
 Val Phe Ile Val Ile Lys Met Pro Ser Ala Lys Gly Arg Ser Lys Ala
             180                 185                 190        
 Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Ser Ile His Tyr Gly
         195                 200                 205            
 Phe Ala Cys Phe Val Tyr Leu Arg Pro Lys Asn Ser Asn Ser Phe Asp
     210                 215                 220                
 Glu Asp Met Leu Thr Ala Met Ile Tyr Thr Ile Leu Met Pro Leu Leu
 225                 230                 235                 240
 Asn Pro Ile Val Tyr Ser Leu Arg Asn Lys Glu Met Gln Ile Ala Leu
                 245                 250                 255    
 Arg Lys Thr Leu Gly Ser Val Phe Gly Val Phe Pro Gln Lys Thr Lys
             260                 265                 270        
 Lys Glu Pro Glu His Leu Lys Lys Leu His Ser Ile Asp Lys
         275                 280                 285    



      <210> 317
      <211> 559
      <212> PRT
      <213> Homo sapiens


      <400> 317
 Met Trp Thr Asn Phe Phe Lys Leu Arg Leu Phe Cys Cys Leu Leu Ala
   1               5                  10                  15    
 Val Leu Met Val Val Val Leu Val Ile Asn Val Thr Gln Val Glu Tyr
              20                  25                  30        
 Leu Asp His Glu Thr Val Ser Ala Thr Phe Ile Asp Ser Ser Gly Gln
          35                  40                  45            
 Phe Val Ser Ser Gln Val Thr Gly Ile Ser Arg Asn Pro Tyr Cys Gly
      50                  55                  60                
 Tyr Asp Gln Gln Thr Leu Ser Ser Gln Glu Arg Met Glu Glu Asp Ser
  65                  70                  75                  80
 Leu Leu Ala Ala Leu His Arg Gln Val Pro Asp Val Gly Pro Val Pro
                  85                  90                  95    
 Phe Val Lys Ser Thr Asp Pro Ser Ser Ser Tyr Phe Val Ile Leu Asn
             100                 105                 110        
 Ser Ala Ala Phe Phe Lys Val Gly Ser Gln Leu Glu Val Leu Val His
         115                 120                 125            
 Val Gln Asp Phe Gln Arg Lys Pro Lys Lys Tyr Gly Gly Asp Tyr Leu
     130                 135                 140                
 Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly Ala Val Gly Arg
 145                 150                 155                 160
 Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe Phe Thr Leu Leu
                 165                 170                 175    
 Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val His Pro Ser Glu
             180                 185                 190        
 Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys Pro Asp Arg Val
         195                 200                 205            
 Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser Glu Thr Thr Glu
     210                 215                 220                
 Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys Asn Phe Thr Asp
 225                 230                 235                 240
 Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro Lys Lys Leu Pro
                 245                 250                 255    
 Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr Leu Lys Gly Leu
             260                 265                 270        
 Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly Val Asn Ile Lys
         275                 280                 285            
 Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr Val Ile Pro Arg
     290                 295                 300                
 Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln Gly Ser Gly Thr
 305                 310                 315                 320
 Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg Pro Arg Lys Phe
                 325                 330                 335    
 Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr Glu Cys Leu Gln
             340                 345                 350        
 Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile Arg Gln Trp Phe
         355                 360                 365            
 Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu Phe Asn Leu Gly
     370                 375                 380                
 Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp Gln Lys His Asn
 385                 390                 395                 400
 Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile Arg Phe Thr Thr
                 405                 410                 415    
 Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu Leu Asn Gly Ile
             420                 425                 430        
 Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val Trp Ser His Phe
         435                 440                 445            
 Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu Arg Asn Ile Arg
     450                 455                 460                
 Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys Thr Val Val Val
 465                 470                 475                 480
 Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu Val Ser Leu Phe
                 485                 490                 495    
 Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile Leu Arg Arg Met
             500                 505                 510        
 Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp Glu Met Thr Leu
         515                 520                 525            
 Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu Val Ile Val Lys
     530                 535                 540                
 Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro Leu Glu Thr
 545                 550                 555                



      <210> 318
      <211> 435
      <212> PRT
      <213> Homo sapiens


      <400> 318
 Met Ala Ala Pro Leu Val Leu Val Leu Val Val Ala Val Thr Val Arg
   1               5                  10                  15    
 Ala Ala Leu Phe Arg Ser Ser Leu Ala Glu Phe Ile Ser Glu Arg Val
              20                  25                  30        
 Glu Val Val Ser Pro Leu Ser Ser Trp Lys Arg Val Val Glu Gly Leu
          35                  40                  45            
 Ser Leu Leu Asp Leu Gly Val Ser Pro Tyr Ser Gly Ala Val Phe His
      50                  55                  60                
 Glu Thr Pro Leu Ile Ile Tyr Leu Phe His Phe Leu Ile Asp Tyr Ala
  65                  70                  75                  80
 Glu Leu Val Phe Met Ile Thr Asp Ala Leu Thr Ala Ile Ala Leu Tyr
                  85                  90                  95    
 Phe Ala Ile Gln Asp Phe Asn Lys Val Val Phe Lys Lys Gln Lys Leu
             100                 105                 110        
 Leu Leu Glu Leu Asp Gln Tyr Ala Pro Asp Val Ala Glu Leu Ile Arg
         115                 120                 125            
 Thr Pro Met Glu Met Arg Tyr Ile Pro Leu Lys Val Ala Leu Phe Tyr
     130                 135                 140                
 Leu Leu Asn Pro Tyr Thr Ile Leu Ser Cys Val Ala Lys Ser Thr Cys
 145                 150                 155                 160
 Ala Ile Asn Asn Thr Leu Ile Ala Phe Phe Ile Leu Thr Thr Ile Lys
                 165                 170                 175    
 Gly Ser Ala Phe Leu Ser Ala Ile Phe Leu Ala Leu Ala Thr Tyr Gln
             180                 185                 190        
 Ser Leu Tyr Pro Leu Thr Leu Phe Val Pro Gly Leu Leu Tyr Leu Leu
         195                 200                 205            
 Gln Arg Gln Tyr Ile Pro Val Lys Met Lys Ser Lys Ala Phe Trp Ile
     210                 215                 220                
 Phe Ser Trp Glu Tyr Ala Met Met Tyr Val Gly Ser Leu Val Val Ile
 225                 230                 235                 240
 Ile Cys Leu Ser Phe Phe Leu Leu Ser Ser Trp Asp Phe Ile Pro Ala
                 245                 250                 255    
 Val Tyr Gly Phe Ile Leu Ser Val Pro Asp Leu Thr Pro Asn Ile Gly
             260                 265                 270        
 Leu Phe Trp Tyr Phe Phe Ala Glu Met Phe Glu His Phe Ser Leu Phe
         275                 280                 285            
 Phe Val Cys Val Phe Gln Ile Asn Val Phe Phe Tyr Thr Ile Pro Leu
     290                 295                 300                
 Ala Ile Lys Leu Lys Glu His Pro Ile Phe Phe Met Phe Ile Gln Ile
 305                 310                 315                 320
 Ala Val Ile Ala Ile Phe Lys Ser Tyr Pro Thr Val Gly Asp Val Ala
                 325                 330                 335    
 Leu Tyr Met Ala Phe Phe Pro Val Trp Asn His Leu Tyr Arg Phe Leu
             340                 345                 350        
 Arg Asn Ile Phe Val Leu Thr Cys Ile Ile Ile Val Cys Ser Leu Leu
         355                 360                 365            
 Phe Pro Val Leu Trp His Leu Trp Ile Tyr Ala Gly Ser Ala Asn Ser
     370                 375                 380                
 Asn Phe Phe Tyr Ala Ile Thr Leu Thr Phe Asn Val Gly Gln Ile Leu
 385                 390                 395                 400
 Leu Ile Ser Asp Tyr Phe Tyr Ala Phe Leu Arg Arg Glu Tyr Tyr Leu
                 405                 410                 415    
 Thr His Gly Leu Tyr Leu Thr Ala Lys Asp Gly Thr Glu Ala Met Leu
             420                 425                 430        
 Val Leu Lys
         435



      <210> 319
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 319
 Met Leu Thr Leu Glu Asp Lys Asp Met Lys Gly Phe Ser Trp Ala Ile
   1               5                  10                  15    
 Val Pro Ala Leu Thr Ser Leu Gly Tyr Leu Ile Ile Leu Val Val Ser
              20                  25                  30        
 Ile Phe Pro Phe Trp Val Arg Leu Thr Asn Glu Glu Ser His Glu Val
          35                  40                  45            
 Phe Phe Ser Gly Leu Phe Glu Asn Cys Phe Asn Ala Lys Cys Trp Lys
      50                  55                  60                
 Pro Arg Pro Leu Ser Ile Tyr Ile Ile Leu Gly Arg Val Phe Leu Leu
  65                  70                  75                  80
 Ser Ala Val Phe Leu Ala Phe Val Thr Thr Phe Ile Met Met Pro Phe
                  85                  90                  95    
 Ala Ser Glu Phe Phe Pro Arg Thr Trp Lys Gln Asn Phe Val Leu Ala
             100                 105                 110        
 Cys Ile Ser Phe Phe Thr Gly Ala Cys Ala Phe Leu Ala Leu Val Leu
         115                 120                 125            
 His Ala Leu Glu Ile Lys Ala Leu Arg Met Lys Leu Gly Pro Leu Gln
     130                 135                 140                
 Phe Ser Val Leu Trp Pro Tyr Tyr Val Leu Gly Phe Gly Ile Phe Leu
 145                 150                 155                 160
 Phe Ile Val Ala Gly Thr Ile Cys Leu Ile Gln Glu Met Val Cys Pro
                 165                 170                 175    
 Cys Trp His Leu Leu Ser Thr Ser Gln Ser Met Glu Glu Asp His Gly
             180                 185                 190        
 Ser Leu Tyr Leu Asp Asn Leu Glu Ser Leu Gly Gly Glu Pro Ser Ser
         195                 200                 205            
 Val Gln Lys Glu Thr Gln Val Thr Ala Glu Thr Val Ile
     210                 215                 220    



      <210> 320
      <211> 360
      <212> PRT
      <213> Homo sapiens


      <400> 320
 Met Thr Asp Ser Arg Val Val Trp Ala Thr Ser Cys Gly Ala Gly Leu
   1               5                  10                  15    
 His Pro Pro Ala Leu Leu Cys Thr Thr Ser Val Leu Cys Cys Phe Ala
              20                  25                  30        
 Ala Glu Pro Thr Gln Ser Cys Arg Trp Val Leu Leu Gly Phe Leu Val
          35                  40                  45            
 Ala Ala Thr Phe Ala Trp Asn Leu Leu Val Leu Ala Thr Ile Leu Arg
      50                  55                  60                
 Val Arg Thr Phe His Arg Val Pro His Asn Leu Val Ala Ser Met Ala
  65                  70                  75                  80
 Val Ser Asp Val Leu Val Ala Ala Leu Val Met Pro Leu Ser Leu Val
                  85                  90                  95    
 His Glu Leu Ser Gly Arg Arg Trp Gln Leu Gly Arg Arg Leu Cys Gln
             100                 105                 110        
 Leu Trp Ile Ala Cys Asp Val Leu Cys Cys Thr Ala Ser Ile Trp Asn
         115                 120                 125            
 Val Thr Ala Ile Ala Leu Asp Arg Tyr Trp Ser Ile Thr Arg His Met
     130                 135                 140                
 Glu Tyr Thr Leu Arg Thr Arg Lys Cys Val Ser Asn Val Met Ile Ala
 145                 150                 155                 160
 Leu Thr Trp Ala Leu Ser Ala Val Ile Ser Leu Ala Pro Leu Leu Phe
                 165                 170                 175    
 Gly Trp Gly Glu Thr Tyr Ser Glu Gly Ser Glu Glu Cys Gln Val Ser
             180                 185                 190        
 Arg Glu Pro Ser Tyr Ala Val Phe Ser Thr Val Gly Ala Phe Tyr Leu
         195                 200                 205            
 Pro Leu Cys Val Val Leu Phe Val Tyr Trp Lys Ile Tyr Lys Ala Ala
     210                 215                 220                
 Lys Phe Arg Val Gly Ser Arg Lys Thr Asn Ser Val Ser Pro Ile Ser
 225                 230                 235                 240
 Glu Ala Val Glu Val Lys Asp Ser Ala Lys Gln Pro Gln Met Val Phe
                 245                 250                 255    
 Thr Val Arg His Ala Thr Val Thr Phe Gln Pro Glu Gly Asp Thr Trp
             260                 265                 270        
 Arg Glu Gln Lys Glu Gln Arg Ala Ala Leu Met Val Gly Ile Leu Ile
         275                 280                 285            
 Gly Val Phe Val Leu Cys Trp Ile Pro Phe Phe Leu Thr Glu Leu Ile
     290                 295                 300                
 Ser Pro Leu Cys Ser Cys Asp Ile Pro Ala Ile Trp Lys Ser Ile Phe
 305                 310                 315                 320
 Leu Trp Leu Gly Tyr Ser Asn Ser Phe Phe Asn Pro Leu Ile Tyr Thr
                 325                 330                 335    
 Ala Phe Asn Lys Asn Tyr Asn Ser Ala Phe Lys Asn Phe Phe Ser Arg
             340                 345                 350        
 Gln His Phe Ile Arg Trp Cys Thr
         355                 360



      <210> 321
      <211> 336
      <212> PRT
      <213> Homo sapiens


      <400> 321
 Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met
   1               5                  10                  15    
 Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly
              20                  25                  30        
 Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr
          35                  40                  45            
 Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val
      50                  55                  60                
 Cys Ser Ala Met Pro Phe Met Ser Ile Tyr Phe Leu Lys Gly Phe Gln
  65                  70                  75                  80
 Trp Glu Tyr Gln Ser Ala Gln Cys Arg Val Val Asn Phe Leu Gly Thr
                  85                  90                  95    
 Leu Ser Met His Ala Ser Met Phe Val Ser Leu Leu Ile Leu Ser Trp
             100                 105                 110        
 Ile Ala Ile Ser Arg Tyr Ala Thr Leu Met Gln Lys Asp Ser Ser Gln
         115                 120                 125            
 Glu Thr Thr Ser Cys Tyr Glu Lys Ile Phe Tyr Gly His Leu Leu Lys
     130                 135                 140                
 Lys Phe Arg Gln Pro Asn Phe Ala Arg Lys Leu Cys Ile Tyr Ile Trp
 145                 150                 155                 160
 Gly Val Val Leu Gly Ile Ile Ile Pro Val Thr Val Tyr Tyr Ser Val
                 165                 170                 175    
 Ile Glu Ala Thr Glu Gly Glu Glu Ser Leu Cys Tyr Asn Arg Gln Met
             180                 185                 190        
 Glu Leu Gly Ala Met Ile Ser Gln Ile Ala Gly Leu Ile Gly Thr Thr
         195                 200                 205            
 Phe Ile Gly Phe Ser Phe Leu Val Val Leu Thr Ser Tyr Tyr Ser Phe
     210                 215                 220                
 Val Ser His Leu Arg Lys Ile Arg Thr Cys Thr Ser Ile Met Glu Lys
 225                 230                 235                 240
 Asp Leu Thr Tyr Ser Ser Val Lys Arg His Leu Leu Val Ile Gln Ile
                 245                 250                 255    
 Leu Leu Ile Val Cys Phe Leu Pro Tyr Ser Ile Phe Lys Pro Ile Phe
             260                 265                 270        
 Tyr Val Leu His Gln Arg Asp Asn Cys Gln Gln Leu Asn Tyr Leu Ile
         275                 280                 285            
 Glu Thr Lys Asn Ile Leu Thr Cys Leu Ala Ser Ala Arg Ser Ser Thr
     290                 295                 300                
 Asp Pro Ile Ile Phe Leu Leu Leu Asp Lys Thr Phe Lys Lys Thr Leu
 305                 310                 315                 320
 Tyr Asn Leu Phe Thr Lys Ser Asn Ser Ala His Met Gln Ser Tyr Gly
                 325                 330                 335    





      <210> 322
      <211> 637
      <212> PRT
      <213> Homo sapiens


      <400> 322
 Met Ile Ala Glu Leu Val Ser Ser Ala Leu Gly Leu Ala Leu Tyr Leu
   1               5                  10                  15    
 Asn Thr Leu Ser Ala Asp Phe Cys Tyr Asp Asp Ser Arg Ala Ile Lys
              20                  25                  30        
 Thr Asn Gln Asp Leu Leu Pro Glu Thr Pro Trp Thr His Ile Phe Tyr
          35                  40                  45            
 Asn Asp Phe Trp Gly Thr Leu Leu Thr His Ser Gly Ser His Lys Ser
      50                  55                  60                
 Tyr Arg Pro Leu Cys Thr Leu Ser Phe Arg Leu Asn His Ala Ile Gly
  65                  70                  75                  80
 Gly Leu Asn Pro Trp Ser Tyr His Leu Val Asn Val Leu Leu His Ala
                  85                  90                  95    
 Ala Val Thr Gly Leu Phe Thr Ser Phe Ser Lys Ile Leu Leu Gly Asp
             100                 105                 110        
 Gly Tyr Trp Thr Phe Met Ala Gly Leu Met Phe Ala Ser His Pro Ile
         115                 120                 125            
 His Thr Glu Ala Val Ala Gly Ile Val Gly Arg Ala Asp Val Gly Ala
     130                 135                 140                
 Ser Leu Phe Phe Leu Leu Ser Leu Leu Cys Tyr Ile Lys His Cys Ser
 145                 150                 155                 160
 Thr Arg Gly Tyr Ser Ala Arg Thr Trp Gly Trp Phe Leu Gly Ser Gly
                 165                 170                 175    
 Leu Cys Ala Gly Cys Ser Met Leu Trp Lys Glu Gln Gly Val Thr Val
             180                 185                 190        
 Leu Ala Val Ser Ala Val Tyr Asp Val Phe Val Phe His Arg Leu Lys
         195                 200                 205            
 Ile Lys Gln Ile Leu Pro Thr Ile Tyr Lys Arg Lys Asn Leu Ser Leu
     210                 215                 220                
 Phe Leu Ser Ile Ser Leu Leu Ile Phe Trp Gly Ser Ser Leu Leu Gly
 225                 230                 235                 240
 Ala Arg Leu Tyr Trp Met Gly Asn Lys Pro Pro Ser Phe Ser Asn Ser
                 245                 250                 255    
 Asp Asn Pro Ala Gly Asp Ser Asp Ser Leu Leu Thr Arg Thr Leu Thr
             260                 265                 270        
 Leu Phe Tyr Leu Pro Thr Lys Asn Leu Trp Leu Leu Leu Cys Pro Asp
         275                 280                 285            
 Thr Leu Ser Phe Asp Trp Ser Met Asp Ala Val Pro Leu Leu Lys Thr
     290                 295                 300                
 Val Cys Asp Trp Arg Asn Leu His Thr Val Ala Phe Tyr Thr Gly Leu
 305                 310                 315                 320
 Leu Leu Leu Ala Tyr Tyr Gly Leu Lys Ser Pro Ser Val Asp Arg Glu
                 325                 330                 335    
 Cys Asn Gly Lys Thr Val Thr Asn Gly Lys Gln Asn Ala Asn Gly His
             340                 345                 350        
 Ser Cys Leu Ser Asp Val Glu Tyr Gln Asn Ser Glu Thr Lys Ser Ser
         355                 360                 365            
 Phe Ala Ser Lys Val Glu Asn Gly Ile Lys Asn Asp Val Ser Gln Arg
     370                 375                 380                
 Thr Gln Leu Pro Ser Thr Glu Asn Ile Val Val Leu Ser Leu Ser Leu
 385                 390                 395                 400
 Leu Ile Ile Pro Phe Val Pro Ala Thr Asn Leu Phe Phe Tyr Val Gly
                 405                 410                 415    
 Phe Val Ile Ala Glu Arg Val Leu Tyr Ile Pro Ser Met Gly Phe Cys
             420                 425                 430        
 Leu Leu Ile Thr Val Gly Ala Arg Ala Leu Tyr Val Lys Val Gln Lys
         435                 440                 445            
 Arg Phe Leu Lys Ser Leu Ile Phe Tyr Ala Thr Ala Thr Leu Ile Val
     450                 455                 460                
 Phe Tyr Gly Leu Lys Thr Ala Ile Arg Asn Gly Asp Trp Gln Asn Glu
 465                 470                 475                 480
 Glu Met Leu Tyr Arg Ser Gly Ile Lys Val Asn Pro Ala Lys Ala Trp
                 485                 490                 495    
 Gly Asn Leu Gly Asn Val Leu Lys Ser Gln Ser Lys Ile Ser Glu Ala
             500                 505                 510        
 Glu Ser Ala Tyr Arg Asn Ala Leu Tyr Tyr Arg Ser Asn Met Ala Asp
         515                 520                 525            
 Met Leu Tyr Asn Leu Gly Leu Leu Leu Gln Glu Asn Ser Arg Phe Ala
     530                 535                 540                
 Glu Ala Leu His Tyr Tyr Lys Leu Ala Ile Gly Ser Arg Pro Thr Leu
 545                 550                 555                 560
 Ala Ser Ala Tyr Leu Asn Thr Gly Ile Ile Leu Met Asn Gln Gly Arg
                 565                 570                 575    
 Thr Glu Glu Ala Arg Arg Thr Phe Leu Lys Cys Ser Glu Ile Pro Asp
             580                 585                 590        
 Glu Asn Leu Lys Asp Pro His Ala His Lys Ser Ser Val Thr Ser Cys
         595                 600                 605            
 Leu Tyr Asn Leu Gly Lys Leu Tyr His Glu Gln Gly His Tyr Glu Val
     610                 615                 620                
 Trp Pro Met Pro Leu Cys Pro Phe Pro Ser Pro Leu Phe
 625                 630                 635        



      <210> 323
      <211> 517
      <212> PRT
      <213> Homo sapiens


      <400> 323
 Met Gly Leu Gly Gln Pro Gln Ala Trp Leu Leu Gly Leu Pro Thr Ala
   1               5                  10                  15    
 Val Val Tyr Gly Ser Leu Ala Leu Phe Thr Thr Ile Leu His Asn Val
              20                  25                  30        
 Phe Leu Leu Tyr Tyr Val Asp Thr Phe Val Ser Val Tyr Lys Ile Asn
          35                  40                  45            
 Lys Met Ala Phe Trp Val Gly Glu Thr Val Phe Leu Leu Trp Asn Ser
      50                  55                  60                
 Leu Asn Asp Pro Leu Phe Gly Trp Leu Ser Asp Arg Gln Phe Leu Ser
  65                  70                  75                  80
 Ser Gln Pro Arg Ser Gly Ala Gly Leu Ser Ser Arg Ala Val Val Leu
                  85                  90                  95    
 Ala Arg Val Gln Ala Leu Gly Trp His Gly Pro Leu Leu Ala Leu Ser
             100                 105                 110        
 Phe Leu Ala Phe Trp Val Pro Trp Ala Pro Ala Gly Leu Gln Phe Leu
         115                 120                 125            
 Leu Cys Leu Cys Leu Tyr Asp Gly Phe Leu Thr Leu Val Asp Leu His
     130                 135                 140                
 His His Ala Leu Leu Ala Asp Leu Ala Leu Ser Ala His Asp Arg Thr
 145                 150                 155                 160
 His Leu Asn Phe Tyr Cys Ser Leu Phe Ser Ala Ala Gly Ser Leu Ser
                 165                 170                 175    
 Val Phe Ala Ser Tyr Ala Phe Trp Asn Lys Glu Asp Phe Ser Ser Phe
             180                 185                 190        
 Arg Ala Phe Cys Val Thr Leu Ala Val Ser Ser Gly Leu Gly Phe Leu
         195                 200                 205            
 Gly Ala Thr Gln Leu Leu Arg Arg Arg Val Glu Ala Ala Arg Lys Asp
     210                 215                 220                
 Pro Gly Cys Ser Gly Leu Val Val Asp Ser Gly Leu Cys Gly Glu Glu
 225                 230                 235                 240
 Leu Leu Val Gly Ser Glu Glu Ala Asp Ser Ile Thr Leu Gly Arg Tyr
                 245                 250                 255    
 Leu Arg Gln Leu Ala Arg His Arg Asn Phe Leu Trp Phe Val Ser Met
             260                 265                 270        
 Asp Leu Val Gln Val Phe His Cys His Phe Asn Ser Asn Phe Phe Pro
         275                 280                 285            
 Leu Phe Leu Glu His Leu Leu Ser Asp His Ile Ser Leu Ser Thr Gly
     290                 295                 300                
 Ser Ile Leu Leu Gly Leu Ser Tyr Val Ala Pro His Leu Asn Asn Leu
 305                 310                 315                 320
 Tyr Phe Leu Ser Leu Cys Arg Arg Trp Gly Val Tyr Ala Val Val Arg
                 325                 330                 335    
 Gly Leu Phe Leu Leu Lys Leu Gly Leu Ser Leu Leu Met Leu Leu Ala
             340                 345                 350        
 Gly Pro Asp His Leu Ser Leu Leu Cys Leu Phe Ile Ala Ser Asn Arg
         355                 360                 365            
 Val Phe Thr Glu Gly Thr Cys Lys Leu Leu Thr Leu Val Val Thr Asp
     370                 375                 380                
 Leu Val Asp Glu Asp Leu Val Leu Asn His Arg Lys Gln Ala Ala Ser
 385                 390                 395                 400
 Ala Leu Leu Phe Gly Met Val Ala Leu Val Thr Lys Pro Gly Gln Thr
                 405                 410                 415    
 Phe Ala Pro Leu Leu Gly Thr Trp Leu Leu Cys Phe Tyr Thr Gly His
             420                 425                 430        
 Asp Leu Phe Gln Gln Ser Leu Ile Thr Pro Val Gly Ser Ala His Pro
         435                 440                 445            
 Trp Pro Glu Pro Pro Ala Pro Ala Pro Ala Gln Ala Pro Thr Leu Arg
     450                 455                 460                
 Gln Gly Cys Phe Tyr Leu Leu Val Leu Val Pro Ile Thr Cys Ala Leu
 465                 470                 475                 480
 Leu Gln Leu Phe Thr Trp Ser Gln Phe Thr Leu His Gly Arg Arg Leu
                 485                 490                 495    
 His Met Val Lys Ala Gln Arg Gln Asn Leu Ser Gln Ala Gln Thr Leu
             500                 505                 510        
 Asp Val Lys Met Val
         515        



      <210> 324
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 324
 Met His Gly Lys Ile Thr Pro Phe Gln Met Tyr Leu Leu His Ser Ile
   1               5                  10                  15    
 Leu Phe Met Leu Cys Leu Val Gly Met Val Glu Phe Asn Lys Ser Thr
              20                  25                  30        
 Arg Glu Cys Ile Leu Phe Lys Thr Leu Trp Leu Ile Pro Leu Phe Thr
          35                  40                  45            
 Tyr Lys Leu Ala Tyr Leu Cys Glu Lys Leu Lys Phe Val Lys Phe Cys
      50                  55                  60                
 Ala Ser Leu Leu Ile Ala Val Phe Asp His
  65                  70                



      <210> 325
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 325
 Met Met Thr Cys Ser Phe Arg Arg Phe Ile Ile Ala Thr Thr Ile Gly
   1               5                  10                  15    
 Ser Asp Ser Lys Lys Met Leu Phe Phe Phe Ser Ile Ala Leu Ser Ser
              20                  25                  30        
 Phe Phe Phe Leu Asn Leu Phe Leu Cys Leu Cys Asn Ser Arg Val Ile
          35                  40                  45            
 Gly Ile Val Leu Thr Ile Ser
      50                  55



      <210> 326
      <211> 244
      <212> PRT
      <213> Homo sapiens


      <400> 326
 Met Val Leu Leu Leu Val Ile Leu Ile Pro Val Leu Met Leu Gly Thr
   1               5                  10                  15    
 Cys Arg Met Val Cys Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr
              20                  25                  30        
 Ala Ala Thr Pro Asp Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile
          35                  40                  45            
 Gln Gly Pro Lys Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg
      50                  55                  60                
 Gly Pro Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly
  65                  70                  75                  80
 Glu Lys Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala
                  85                  90                  95    
 Pro Gly Leu Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr
             100                 105                 110        
 Gly Pro Lys Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly
         115                 120                 125            
 Tyr Glu Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His
     130                 135                 140                
 Tyr Asp Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr
 145                 150                 155                 160
 Phe Phe Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met
                 165                 170                 175    
 Trp Ala Asp Leu Cys Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala
             180                 185                 190        
 Gln Asp Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu
         195                 200                 205            
 His Leu Glu Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys
     210                 215                 220                
 Ala His Gly Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile
 225                 230                 235                 240
 Ile Tyr Ala Asp
                



      <210> 327
      <211> 577
      <212> PRT
      <213> Homo sapiens


      <400> 327
 Met Ala Glu Ala Ala Thr Gly Phe Leu Glu Gln Leu Lys Ser Cys Ile
   1               5                  10                  15    
 Val Trp Ser Trp Thr Tyr Leu Trp Thr Val Trp Phe Phe Ile Val Leu
              20                  25                  30        
 Phe Leu Val Tyr Ile Leu Arg Val Pro Leu Lys Ile Asn Asp Asn Leu
          35                  40                  45            
 Ser Thr Val Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val
      50                  55                  60                
 Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe
  65                  70                  75                  80
 Glu Trp Trp His Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val
                  85                  90                  95    
 Ser Val Ser His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser
             100                 105                 110        
 Ser Asn Asn Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln
         115                 120                 125            
 Ser Val Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg
     130                 135                 140                
 Gly Ala Glu Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu
 145                 150                 155                 160
 Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe
                 165                 170                 175    
 Thr Cys Asp Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys
             180                 185                 190        
 Ala Trp Arg Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu
         195                 200                 205            
 Ala Leu Glu Ile Asn Glu Ile Arg Ser Arg Val Glu Val Pro Leu Ile
     210                 215                 220                
 Ala Ser Ser Thr Ile Trp Glu Ile Lys Leu Leu Pro Lys Cys Ala Thr
 225                 230                 235                 240
 Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Ala Glu Ala
                 245                 250                 255    
 Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly Asp Gly Cys Tyr Arg
             260                 265                 270        
 Arg Ser Gln Gln Leu Gln His His Gly Ser Gln Tyr Glu Ala Gln His
         275                 280                 285            
 Arg Arg Asp Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met
     290                 295                 300                
 Cys Ala Arg Arg Leu Gly Arg Thr Arg Glu Ala Val Lys Met Met Arg
 305                 310                 315                 320
 Asp Leu Met Lys Glu Phe Pro Leu Leu Ser Met Phe Asn Ile His Glu
                 325                 330                 335    
 Asn Leu Leu Glu Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln
             340                 345                 350        
 Ala Val Leu Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr
         355                 360                 365            
 Ile Cys Tyr Thr Ala Ala Leu Leu Lys Ala Arg Ala Val Ser Asp Lys
     370                 375                 380                
 Phe Ser Pro Glu Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Met
 385                 390                 395                 400
 Asn Ala Val Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val
                 405                 410                 415    
 Pro Lys Tyr Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His
             420                 425                 430        
 Ile Leu Lys Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His
         435                 440                 445            
 Leu Ala His Trp Lys Arg Val Glu Gly Ala Leu Asn Leu Leu His Cys
     450                 455                 460                
 Thr Trp Glu Gly Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly
 465                 470                 475                 480
 His Leu Phe Tyr Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu
                 485                 490                 495    
 Leu Leu Pro Ser Phe His Glu Val Ser Val Tyr Pro Lys Lys Glu Leu
             500                 505                 510        
 Pro Phe Phe Ile Leu Phe Thr Ala Gly Leu Cys Ser Phe Thr Ala Met
         515                 520                 525            
 Leu Ala Leu Leu Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala
     530                 535                 540                
 Lys Ala Phe Leu Ser Thr Leu Phe Ala Pro Leu Asn Phe Val Met Glu
 545                 550                 555                 560
 Lys Val Glu Ser Ile Leu Pro Ser Ser Leu Trp His Gln Leu Thr Arg
                 565                 570                 575    
 Ile
    



      <210> 328
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 328
 Met Ala Glu Ala Ala Thr Gly Phe Leu Glu Gln Leu Lys Ser Cys Ile
   1               5                  10                  15    
 Val Trp Ser Trp Thr Tyr Leu Trp Thr Val Trp Phe Phe Ile Val Leu
              20                  25                  30        
 Phe Leu Val Tyr Ile Leu Arg Val Pro Leu Lys Ile Asn Asp Asn Leu
          35                  40                  45            
 Ser Thr Val Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val
      50                  55                  60                
 Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe
  65                  70                  75                  80
 Glu Trp Trp His Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val
                  85                  90                  95    
 Ser Val Ser His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser
             100                 105                 110        
 Ser Asn Asn Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln
         115                 120                 125            
 Ser Val Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg
     130                 135                 140                
 Gly Ala Glu Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu
 145                 150                 155                 160
 Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe
                 165                 170                 175    
 Thr Cys Asp Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys
             180                 185                 190        
 Ala Trp Arg Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu
         195                 200                 205            
 Ala Leu Glu Ile Asn Glu Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu
     210                 215                 220                
 Glu Glu Ala Thr Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala
 225                 230                 235                 240
 Leu Lys Ala Gly Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His
                 245                 250                 255    
 His Gly Ser Gln Tyr Glu Ala Gln His Arg Arg Asp Thr Asn Val Leu
             260                 265                 270        
 Val Tyr Ile Lys Arg Arg Leu Ala Met Cys Ala Arg Arg Leu Gly Arg
         275                 280                 285            
 Thr Arg Glu Ala Val Lys Met Met Arg Asp Leu Met Lys Glu Phe Pro
     290                 295                 300                
 Leu Leu Ser Met Phe Asn Ile His Glu Asn Leu Leu Glu Ala Leu Leu
 305                 310                 315                 320
 Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala Lys Tyr Asp
                 325                 330                 335    
 Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr Ala Ala Leu
             340                 345                 350        
 Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu Ala Ala Ser
         355                 360                 365            
 Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu Ala Ile His
     370                 375                 380                
 Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu Leu Glu Met
 385                 390                 395                 400
 Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg Gly Asp Ser
                 405                 410                 415    
 Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp Lys Arg Val
             420                 425                 430        
 Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly Thr Phe Arg
         435                 440                 445            
 Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr Pro Tyr Pro
     450                 455                 460                
 Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser Met Leu Ala
 465                 470                 475                 480
 Leu Leu Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala
                 485                 490                 495    
 Phe Leu Ser Thr Leu Phe Ala Pro Leu Asn Phe Val Met Glu Lys Val
             500                 505                 510        
 Glu Ser Ile Leu Pro Ser Ser Leu Trp His Gln Leu Thr Arg Ile
         515                 520                 525        



      <210> 329
      <211> 568
      <212> PRT
      <213> Homo sapiens


      <400> 329
 Met Ala Glu Ala Ala Thr Gly Phe Leu Glu Gln Leu Lys Ser Cys Ile
   1               5                  10                  15    
 Val Trp Ser Trp Thr Tyr Leu Trp Thr Val Trp Phe Phe Ile Val Leu
              20                  25                  30        
 Phe Leu Val Tyr Ile Leu Arg Val Pro Leu Lys Ile Asn Asp Asn Leu
          35                  40                  45            
 Ser Thr Val Ser Met Phe Leu Asn Thr Leu Thr Pro Lys Phe Tyr Val
      50                  55                  60                
 Ala Leu Thr Gly Thr Ser Ser Leu Ile Ser Gly Leu Ile Leu Ile Phe
  65                  70                  75                  80
 Glu Trp Trp Tyr Phe Arg Lys Tyr Gly Thr Ser Phe Ile Glu Gln Val
                  85                  90                  95    
 Ser Val Ser His Leu Arg Pro Leu Leu Gly Gly Val Asp Asn Asn Ser
             100                 105                 110        
 Ser Asn Asn Ser Asn Ser Ser Asn Gly Asp Ser Asp Ser Asn Arg Gln
         115                 120                 125            
 Ser Val Ser Glu Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg
     130                 135                 140                
 Gly Ala Glu Tyr Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu
 145                 150                 155                 160
 Thr Tyr Tyr Asp Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe
                 165                 170                 175    
 Thr Cys Asp Ser Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys
             180                 185                 190        
 Ala Trp Arg Glu Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu
         195                 200                 205            
 Ala Leu Glu Ile Asn Glu Ile Arg Ser Arg Val Glu Val Pro Leu Ile
     210                 215                 220                
 Ala Ser Ser Thr Ile Trp Glu Ile Lys Leu Leu Pro Lys Cys Ala Thr
 225                 230                 235                 240
 Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr Thr Ile Ala Glu Ala
                 245                 250                 255    
 Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly Asp Gly Cys Tyr Arg
             260                 265                 270        
 Arg Ser Gln Gln Leu Gln His His Gly Ser Gln Tyr Glu Ala Gln His
         275                 280                 285            
 Arg Arg Asp Thr Asn Val Leu Val Tyr Ile Lys Arg Arg Leu Ala Met
     290                 295                 300                
 Cys Ala Arg Arg Leu Gly Arg Thr Arg Glu Ala Val Lys Met Met Arg
 305                 310                 315                 320
 Asp Leu Met Lys Glu Phe Pro Leu Leu Ser Met Phe Asn Ile His Glu
                 325                 330                 335    
 Asn Leu Leu Glu Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln
             340                 345                 350        
 Ala Val Leu Ala Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr
         355                 360                 365            
 Ile Cys Tyr Thr Ala Ala Leu Leu Lys Ala Arg Ala Val Ser Asp Lys
     370                 375                 380                
 Phe Ser Pro Glu Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Met
 385                 390                 395                 400
 Asn Ala Val Glu Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val
                 405                 410                 415    
 Pro Lys Tyr Leu Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His
             420                 425                 430        
 Ile Leu Lys Arg Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His
         435                 440                 445            
 Leu Ala His Trp Lys Arg Val Glu Gly Ala Leu Asn Leu Leu His Cys
     450                 455                 460                
 Thr Trp Glu Gly Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly
 465                 470                 475                 480
 His Leu Phe Tyr Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu
                 485                 490                 495    
 Leu Leu Pro Ser Phe His Glu Val Ser Val Tyr Pro Lys Lys Glu Leu
             500                 505                 510        
 Pro Phe Phe Ile Leu Phe Thr Ala Gly Leu Cys Ser Phe Thr Ala Met
         515                 520                 525            
 Leu Ala Leu Leu Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala
     530                 535                 540                
 Lys Ala Val Ser Val Cys Leu Glu Gly Gly Leu Gly Glu Trp Met Gly
 545                 550                 555                 560
 Lys Ala Lys Gly Ile Lys Ala Ala
                 565            



      <210> 330
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 330
 Met Ala Cys Val Ser Val Asp His Tyr Pro Ala Val Val Cys Ala His
   1               5                  10                  15    
 Trp Gly Pro Cys Leu Arg Thr Ala Gly Arg Ala Arg Leu Val Cys Val
              20                  25                  30        
 Ala Ile Trp Thr Leu Val Leu Leu Gln Thr Met Pro Leu Leu Leu Met
          35                  40                  45            
 Pro Met Thr Lys Pro Leu Val Gly Lys Leu Ala Cys Met Glu Tyr Ser
      50                  55                  60                
 Ser Met Glu Ser Val Leu Gly Leu Pro Leu Met Val Leu Val Ala Phe
  65                  70                  75                  80
 Ala Ile Gly Phe Cys Gly Pro Val Gly Ile Ile Leu Ser Cys Tyr Met
                  85                  90                  95    
 Lys Ile Thr Trp Lys Leu Cys Ser Thr Ala Asp Pro Val Thr Ser Arg
             100                 105                 110        
 Lys Gly Arg His Trp Arg Gly Cys Leu Leu Thr Leu Leu Met Leu Val
         115                 120                 125            
 Ala Val Val Val Cys Phe Ser Pro Tyr His Leu Asn Ile Lys Gln Phe
     130                 135                 140                
 Met Ala Arg Gly Met Leu His Leu Pro Ser Cys Ala Glu Arg Arg Ala
 145                 150                 155                 160
 Phe Leu Leu Ser Leu Gln Ala Thr Val Ala Leu Met Asn Met Asn Cys
                 165                 170                 175    
 Gly Ile Thr Pro Ser Phe Thr Ser Leu His Pro Pro Ile Thr Gly Asn
             180                 185                 190        
 Gly Ser Trp Ala Phe
         195        



      <210> 331
      <211> 1049
      <212> PRT
      <213> Homo sapiens


      <400> 331
 Met Glu Lys Arg Leu Gly Val Lys Pro Asn Pro Ala Ser Trp Ile Leu
   1               5                  10                  15    
 Ser Gly Tyr Tyr Trp Gln Thr Ser Ala Lys Trp Leu Arg Ser Leu Tyr
              20                  25                  30        
 Leu Phe Tyr Thr Cys Phe Cys Phe Ser Val Leu Trp Leu Ser Thr Asp
          35                  40                  45            
 Ala Ser Glu Ser Arg Cys Gln Gln Gly Lys Thr Gln Phe Gly Val Gly
      50                  55                  60                
 Leu Arg Ser Gly Gly Glu Asn His Leu Trp Leu Leu Glu Gly Thr Pro
  65                  70                  75                  80
 Ser Leu Gln Ser Cys Trp Ala Ala Cys Cys Gln Asp Ser Ala Cys His
                  85                  90                  95    
 Val Phe Trp Trp Leu Glu Gly Met Cys Ile Gln Ala Asp Cys Ser Arg
             100                 105                 110        
 Pro Gln Ser Cys Arg Ala Phe Arg Thr His Ser Ser Asn Ser Met Leu
         115                 120                 125            
 Val Phe Leu Lys Lys Phe Gln Thr Ala Asp Asp Leu Gly Phe Leu Pro
     130                 135                 140                
 Glu Asp Asp Val Pro His Leu Leu Gly Leu Gly Trp Asn Trp Ala Ser
 145                 150                 155                 160
 Trp Arg Gln Ser Pro Pro Arg Ala Ala Leu Arg Pro Ala Val Ser Ser
                 165                 170                 175    
 Ser Asp Gln Gln Ser Leu Ile Arg Lys Leu Gln Lys Arg Gly Ser Pro
             180                 185                 190        
 Ser Asp Val Val Thr Pro Ile Val Thr Gln His Ser Lys Val Asn Asp
         195                 200                 205            
 Ser Asn Glu Leu Gly Gly Leu Thr Thr Ser Gly Ser Ala Glu Val His
     210                 215                 220                
 Lys Ala Ile Thr Ile Ser Ser Pro Leu Thr Thr Asp Leu Thr Ala Glu
 225                 230                 235                 240
 Leu Ser Gly Gly Pro Lys Asn Val Ser Val Gln Pro Glu Ile Ser Glu
                 245                 250                 255    
 Gly Leu Ala Thr Thr Pro Ser Thr Gln Gln Val Lys Ser Ser Glu Lys
             260                 265                 270        
 Thr Gln Ile Ala Val Pro Gln Pro Val Ala Pro Ser Tyr Ser Tyr Ala
         275                 280                 285            
 Thr Pro Thr Pro Gln Ala Ser Phe Gln Ser Thr Ser Ala Pro Tyr Pro
     290                 295                 300                
 Val Ile Lys Glu Leu Val Val Ser Ala Gly Glu Ser Val Gln Ile Thr
 305                 310                 315                 320
 Leu Pro Lys Asn Glu Val Gln Leu Asn Ala Tyr Val Leu Gln Glu Pro
                 325                 330                 335    
 Pro Lys Gly Glu Thr Tyr Thr Tyr Asp Trp Gln Leu Ile Thr His Pro
             340                 345                 350        
 Arg Asp Tyr Ser Gly Glu Met Glu Gly Lys His Ser Gln Ile Leu Lys
         355                 360                 365            
 Leu Ser Lys Leu Thr Pro Gly Leu Tyr Glu Phe Lys Val Ile Val Glu
     370                 375                 380                
 Gly Gln Asn Ala His Gly Glu Gly Tyr Val Asn Val Thr Val Lys Pro
 385                 390                 395                 400
 Glu Pro Arg Lys Asn Arg Pro Pro Ile Ala Ile Val Ser Pro Gln Phe
                 405                 410                 415    
 Gln Glu Ile Ser Leu Pro Thr Thr Ser Thr Val Ile Asp Gly Ser Gln
             420                 425                 430        
 Ser Thr Asp Asp Asp Lys Ile Val Gln Tyr His Trp Glu Glu Leu Lys
         435                 440                 445            
 Gly Pro Leu Arg Glu Glu Lys Ile Ser Glu Asp Thr Ala Ile Leu Lys
     450                 455                 460                
 Leu Ser Lys Leu Val Pro Gly Asn Tyr Thr Phe Ser Leu Thr Val Val
 465                 470                 475                 480
 Asp Ser Asp Gly Ala Thr Asn Ser Thr Thr Ala Asn Leu Thr Val Asn
                 485                 490                 495    
 Lys Ala Val Asp Tyr Pro Pro Val Ala Asn Ala Gly Pro Asn Gln Val
             500                 505                 510        
 Ile Thr Leu Pro Gln Asn Ser Ile Thr Leu Phe Gly Asn Gln Ser Thr
         515                 520                 525            
 Asp Asp His Gly Ile Thr Ser Tyr Glu Trp Ser Leu Ser Pro Ser Ser
     530                 535                 540                
 Lys Gly Lys Val Val Glu Met Gln Gly Val Arg Thr Pro Thr Leu Gln
 545                 550                 555                 560
 Leu Ser Ala Met Gln Glu Gly Asp Tyr Thr Tyr Gln Leu Thr Val Thr
                 565                 570                 575    
 Asp Thr Ile Gly Gln Gln Ala Thr Ala Gln Val Thr Val Ile Val Gln
             580                 585                 590        
 Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp Ala Gly Pro Asp Lys Glu
         595                 600                 605            
 Leu Thr Leu Pro Val Asp Ser Thr Thr Leu Asp Gly Ser Lys Ser Ser
     610                 615                 620                
 Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp Glu Lys Thr Gln Gly Pro
 625                 630                 635                 640
 Asp Gly Val Gln Leu Glu Asn Ala Asn Ser Ser Val Ala Thr Val Thr
                 645                 650                 655    
 Gly Leu Gln Val Gly Thr Tyr Val Phe Thr Leu Thr Val Lys Asp Glu
             660                 665                 670        
 Arg Asn Leu Gln Ser Gln Ser Ser Val Asn Val Ile Val Lys Glu Glu
         675                 680                 685            
 Ile Asn Lys Pro Pro Ile Ala Lys Ile Thr Gly Asn Val Val Ile Thr
     690                 695                 700                
 Leu Pro Thr Ser Thr Ala Glu Leu Asp Gly Ser Lys Ser Ser Asp Asp
 705                 710                 715                 720
 Lys Gly Ile Val Ser Tyr Leu Trp Thr Arg Asp Glu Gly Ser Pro Ala
                 725                 730                 735    
 Ala Gly Glu Val Leu Asn His Ser Asp His His Pro Ile Leu Phe Leu
             740                 745                 750        
 Ser Asn Leu Val Glu Gly Thr Tyr Thr Phe His Leu Lys Val Thr Asp
         755                 760                 765            
 Ala Lys Gly Glu Ser Asp Thr Asp Arg Thr Thr Val Glu Val Lys Pro
     770                 775                 780                
 Asp Pro Arg Lys Asn Asn Leu Val Glu Ile Ile Leu Asp Ile Asn Val
 785                 790                 795                 800
 Ser Gln Leu Thr Glu Arg Leu Lys Gly Met Phe Ile Arg Gln Ile Gly
                 805                 810                 815    
 Val Leu Leu Gly Val Leu Asp Ser Asp Ile Ile Val Gln Lys Ile Gln
             820                 825                 830        
 Pro Tyr Thr Glu Gln Ser Thr Lys Met Val Phe Phe Val Gln Asn Glu
         835                 840                 845            
 Pro Pro His Gln Ile Phe Lys Gly His Glu Val Ala Ala Met Leu Lys
     850                 855                 860                
 Ser Glu Leu Arg Lys Gln Lys Ala Asp Phe Leu Ile Phe Arg Ala Leu
 865                 870                 875                 880
 Glu Val Asn Thr Val Thr Cys Gln Leu Asn Cys Ser Asp His Gly His
                 885                 890                 895    
 Cys Asp Ser Phe Thr Lys Arg Cys Ile Cys Asp Pro Phe Trp Met Glu
             900                 905                 910        
 Asn Phe Ile Lys Val Gln Leu Arg Asp Gly Asp Ser Asn Cys Glu Trp
         915                 920                 925            
 Ser Val Leu Tyr Val Ile Ile Ala Thr Phe Val Ile Val Val Ala Leu
     930                 935                 940                
 Gly Ile Leu Ser Trp Thr Val Ile Cys Cys Cys Lys Arg Gln Lys Gly
 945                 950                 955                 960
 Lys Pro Lys Arg Lys Ser Lys Tyr Lys Ile Leu Asp Ala Thr Asp Gln
                 965                 970                 975    
 Glu Ser Leu Glu Leu Lys Pro Thr Ser Arg Ala Gly Ile Lys Gln Lys
             980                 985                 990        
 Gly Leu Leu Leu Ser Ser Ser Leu Met His Ser Glu Ser Glu Leu Asp
         995                1000                1005            
 Ser Asp Asp Ala Ile Phe Thr Trp Pro Asp Arg Glu Lys Gly Lys Leu
    1010                1015                1020                
 Leu His Gly Gln Asn Gly Ser Val Pro Asn Gly Gln Thr Pro Leu Lys
1025                1030                1035                1040
 Ala Arg Ser Pro Arg Glu Glu Ile Leu
                1045                



      <210> 332
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 332
 Met Arg Pro Leu Pro Ser Gly Arg Arg Lys Thr Arg Gly Ile Ser Leu
   1               5                  10                  15    
 Gly Leu Phe Ala Leu Cys Leu Ala Ala Ala Arg Cys Leu Gln Ser Gln
              20                  25                  30        
 Gly Val Ser Leu Tyr Ile Pro Gln Ala Thr Ile Asn Ala Thr Val Lys
          35                  40                  45            
 Glu Asp Ile Leu Leu Ser Val Glu Tyr Ser Cys His Gly Val Pro Thr
      50                  55                  60                
 Ile Glu Trp Thr Tyr Ser Ser Asn Trp Gly Thr Gln Lys Ile Val Glu
  65                  70                  75                  80
 Trp Lys Pro Gly Thr Gln Ala Asn Ile Ser Gln Ser His Lys Asp Arg
                  85                  90                  95    
 Val Cys Thr Phe Asp Asn Gly Ser Ile Gln Leu Phe Ser Val Gly Val
             100                 105                 110        
 Arg Asp Ser Gly Tyr Tyr Val Ile Thr Val Thr Glu Arg Leu Gly Ser
         115                 120                 125            
 Ser Gln Phe Gly Thr Ile Val Leu His Val Ser Glu Ile Leu Tyr Glu
     130                 135                 140                
 Asp Leu His Phe Val Ala Val Ile Leu Ala Phe Leu Ala Ala Val Ala
 145                 150                 155                 160
 Ala Val Leu Ile Ser Leu Met Trp Val Cys Asn Lys Cys Ala Tyr Lys
                 165                 170                 175    
 Phe Gln Arg Lys Arg Arg His Lys Leu Lys Glu Ser Thr Thr Glu Glu
             180                 185                 190        
 Ile Glu Leu Glu Asp Val Glu Cys
         195                 200



      <210> 333
      <211> 371
      <212> PRT
      <213> Homo sapiens


      <400> 333
 Met Leu Gly Ser Arg Ala Ala Gly Phe Ala Arg Gly Leu Arg Ala Val
   1               5                  10                  15    
 Ala Leu Ala Trp Leu Pro Gly Trp Arg Gly Arg Ser Phe Ala Leu Ala
              20                  25                  30        
 Arg Ala Ala Gly Ala Pro His Gly Gly Asp Leu Gln Pro Pro Ala Cys
          35                  40                  45            
 Pro Glu Pro Arg Gly Arg Gln Leu Ser Leu Ser Ala Ala Ala Val Val
      50                  55                  60                
 Asp Ser Ala Pro Arg Pro Leu Gln Pro Tyr Leu Arg Leu Met Arg Leu
  65                  70                  75                  80
 Asp Lys Pro Ile Gly Thr Trp Leu Leu Tyr Leu Pro Cys Thr Trp Ser
                  85                  90                  95    
 Ile Gly Leu Ala Ala Glu Pro Gly Cys Phe Pro Asp Trp Tyr Met Leu
             100                 105                 110        
 Ser Leu Phe Gly Thr Gly Ala Ile Leu Met Arg Gly Ala Gly Cys Thr
         115                 120                 125            
 Ile Asn Asp Met Trp Asp Gln Asp Tyr Asp Lys Lys Val Thr Arg Thr
     130                 135                 140                
 Ala Asn Arg Pro Ile Ala Ala Gly Asp Ile Ser Thr Phe Gln Ser Phe
 145                 150                 155                 160
 Val Phe Leu Gly Gly Gln Leu Thr Leu Ala Leu Gly Val Leu Leu Cys
                 165                 170                 175    
 Leu Asn Tyr Tyr Ser Ile Ala Leu Gly Ala Gly Ser Leu Leu Leu Val
             180                 185                 190        
 Ile Thr Tyr Pro Leu Met Lys Arg Ile Ser Tyr Trp Pro Gln Leu Ala
         195                 200                 205            
 Leu Gly Leu Thr Phe Asn Trp Gly Ala Leu Leu Gly Trp Ser Ala Ile
     210                 215                 220                
 Lys Gly Ser Cys Asp Pro Ser Val Cys Leu Pro Leu Tyr Phe Ser Gly
 225                 230                 235                 240
 Val Met Trp Thr Leu Ile Tyr Asp Thr Ile Tyr Ala His Gln Asp Lys
                 245                 250                 255    
 Arg Asp Asp Val Leu Ile Gly Leu Lys Ser Thr Ala Leu Arg Phe Gly
             260                 265                 270        
 Glu Asn Thr Lys Pro Trp Leu Ser Gly Phe Ser Val Ala Met Leu Gly
         275                 280                 285            
 Ala Leu Ser Leu Val Gly Val Asn Ser Gly Gln Thr Ala Pro Tyr Tyr
     290                 295                 300                
 Ala Ala Leu Gly Ala Val Gly Ala His Leu Thr His Gln Ile Tyr Thr
 305                 310                 315                 320
 Leu Asp Ile His Arg Pro Glu Asp Cys Trp Asn Lys Phe Ile Ser Asn
                 325                 330                 335    
 Arg Thr Leu Gly Leu Ile Val Phe Leu Gly Ile Val Leu Gly Asn Leu
             340                 345                 350        
 Trp Lys Glu Lys Lys Thr Asp Lys Thr Lys Lys Gly Ile Glu Asn Lys
         355                 360                 365            
 Ile Glu Asn
     370    



      <210> 334
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 334
 Met Cys Thr Gly Gly Cys Ala Arg Cys Leu Gly Gly Thr Leu Ile Pro
   1               5                  10                  15    
 Leu Ala Phe Phe Gly Phe Leu Ala Asn Ile Leu Leu Phe Phe Pro Gly
              20                  25                  30        
 Gly Ile Leu Gly Ser Gly Val Leu Met Ile Phe Pro Ala Leu Val Phe
          35                  40                  45            
 Leu Gly Leu Lys Asn Asn Asp Cys Cys Gly Cys Cys Gly Asn Glu Gly
      50                  55                  60                
 Cys Gly Lys Arg Phe Ala Met Phe Thr Ser Thr Ile Phe Ala Val Val
  65                  70                  75                  80
 Gly Phe Leu Gly Ala Gly Tyr Ser Phe Ile Ile Ser Ala Ile Ser Ile
                  85                  90                  95    
 Asn Lys Gly Pro Lys Cys Leu Met Ala Asn Ser Thr Trp Gly Tyr Pro
             100                 105                 110        
 Phe His Asp Gly Asp Tyr Leu Asn Asp Glu Ala Leu Trp Asn Lys Cys
         115                 120                 125            
 Arg Glu Pro Leu Asn Val Val Pro Trp Asn Leu Thr Leu Phe Ser Ile
     130                 135                 140                
 Leu Leu Val Val Gly Gly Ile Gln Met Val Leu Cys Ala Ile Gln Val
 145                 150                 155                 160
 Val Asn Gly Leu Leu Gly Thr Leu Cys Gly Asp Cys Gln Cys Cys Gly
                 165                 170                 175    
 Cys Cys Gly Gly Asp Gly Pro Val
             180                



      <210> 335
      <211> 563
      <212> PRT
      <213> Homo sapiens


      <400> 335
 Met Gly Ser Leu Ser Asn Tyr Ala Leu Leu Gln Leu Thr Leu Thr Ala
   1               5                  10                  15    
 Phe Leu Thr Ile Leu Val Gln Pro Gln His Leu Leu Ala Pro Val Phe
              20                  25                  30        
 Arg Thr Leu Ser Ile Leu Thr Asn Gln Ser Asn Cys Trp Leu Cys Glu
          35                  40                  45            
 His Leu Asp Asn Ala Glu Gln Pro Glu Leu Val Phe Val Pro Ala Ser
      50                  55                  60                
 Ala Ser Thr Trp Trp Thr Tyr Ser Gly Gln Trp Met Tyr Glu Arg Val
  65                  70                  75                  80
 Trp Tyr Pro Gln Ala Glu Val Gln Asn His Ser Thr Ser Ser Tyr Arg
                  85                  90                  95    
 Lys Val Thr Trp His Trp Glu Ala Ser Met Glu Ala Gln Gly Leu Ser
             100                 105                 110        
 Phe Ala Gln Val Arg Leu Leu Glu Gly Asn Phe Ser Leu Cys Val Glu
         115                 120                 125            
 Asn Lys Asn Gly Ser Gly Pro Phe Leu Gly Asn Ile Pro Lys Gln Tyr
     130                 135                 140                
 Cys Asn Gln Ile Leu Trp Phe Asp Ser Thr Asp Gly Thr Phe Met Pro
 145                 150                 155                 160
 Ser Ile Asp Val Thr Asn Glu Ser Arg Asn Asp Asp Asp Asp Thr Ser
                 165                 170                 175    
 Val Cys Leu Gly Thr Arg Gln Cys Ser Trp Phe Ala Gly Cys Thr Asn
             180                 185                 190        
 Arg Thr Trp Asn Ser Ser Ala Val Pro Leu Ile Gly Leu Pro Asn Thr
         195                 200                 205            
 Gln Asp Tyr Lys Trp Val Asp Arg Asn Ser Gly Leu Thr Trp Ser Gly
     210                 215                 220                
 Asn Asp Thr Cys Leu Tyr Ser Phe Gln Asn Gln Thr Lys Gly Leu Leu
 225                 230                 235                 240
 Tyr Gln Leu Phe Arg Asn Leu Phe Cys Ser Tyr Gly Leu Thr Glu Ala
                 245                 250                 255    
 His Gly Lys Trp Arg Cys Ala Asp Ala Ser Ile Thr Asn Asp Lys Gly
             260                 265                 270        
 His Asp Gly His Arg Thr Pro Thr Trp Trp Leu Thr Gly Ser Asn Leu
         275                 280                 285            
 Thr Leu Ser Val Asn Asn Ser Gly Leu Phe Phe Leu Cys Gly Asn Gly
     290                 295                 300                
 Val Tyr Lys Gly Phe Pro Pro Lys Trp Ser Gly Arg Cys Gly Leu Gly
 305                 310                 315                 320
 Tyr Leu Val Pro Ser Leu Thr Arg Tyr Leu Thr Leu Asn Ala Ser Gln
                 325                 330                 335    
 Ile Thr Asn Leu Arg Ser Phe Ile His Lys Val Thr Pro His Arg Cys
             340                 345                 350        
 Thr Gln Gly Asp Thr Asp Asn Pro Pro Leu Tyr Cys Asn Pro Lys Asp
         355                 360                 365            
 Asn Ser Thr Ile Arg Ala Leu Phe Pro Ser Leu Gly Thr Tyr Asp Leu
     370                 375                 380                
 Glu Lys Ala Ile Leu Asn Ile Ser Lys Ala Met Glu Gln Glu Phe Ser
 385                 390                 395                 400
 Ala Thr Lys Gln Thr Leu Glu Ala His Gln Ser Lys Val Ser Ser Leu
                 405                 410                 415    
 Ala Ser Ala Ser Arg Lys Asp His Val Leu Asp Ile Pro Thr Thr Gln
             420                 425                 430        
 Arg Gln Thr Ala Cys Gly Thr Val Gly Lys Gln Cys Cys Leu Tyr Ile
         435                 440                 445            
 Asn Tyr Ser Glu Glu Ile Lys Ser Asn Ile Gln Arg Leu His Glu Ala
     450                 455                 460                
 Ser Glu Asn Leu Lys Asn Val Pro Leu Leu Asp Trp Gln Gly Ile Phe
 465                 470                 475                 480
 Ala Lys Val Gly Asp Trp Phe Arg Ser Trp Gly Tyr Val Leu Leu Ile
                 485                 490                 495    
 Val Leu Phe Cys Leu Phe Ile Phe Val Leu Ile Tyr Val Arg Val Phe
             500                 505                 510        
 Arg Lys Ser Arg Arg Ser Leu Asn Ser Gln Pro Leu Asn Leu Ala Leu
         515                 520                 525            
 Ser Pro Gln Gln Ser Ala Gln Leu Leu Val Ser Glu Thr Ser Cys Gln
     530                 535                 540                
 Val Ser Asn Arg Ala Met Lys Gly Leu Thr Thr His Gln Tyr Asp Thr
 545                 550                 555                 560
 Ser Leu Leu
            



      <210> 336
      <211> 771
      <212> PRT
      <213> Homo sapiens


      <400> 336
 Met Gly Arg Ala Gly Thr Gly Thr Gly Gly Glu Ala Val Ala Ala Val
   1               5                  10                  15    
 Val Ala Gly Pro Leu Leu Leu Leu Leu Leu Ala Arg Pro Pro Pro Ala
              20                  25                  30        
 Ser Ala Gly Tyr Ser Gly Lys Ser Glu Val Gly Leu Val Ser Glu His
          35                  40                  45            
 Phe Ser Gln Ala Pro Gln Arg Leu Ser Phe Tyr Ser Trp Tyr Gly Ser
      50                  55                  60                
 Ala Arg Leu Phe Arg Phe Arg Val Pro Pro Asp Ala Val Leu Leu Arg
  65                  70                  75                  80
 Trp Leu Leu Gln Val Ser Arg Glu Ser Gly Ala Ala Cys Thr Asp Ala
                  85                  90                  95    
 Glu Ile Thr Val His Phe Arg Ser Gly Ala Pro Pro Val Ile Asn Pro
             100                 105                 110        
 Leu Gly Thr Ser Phe Pro Asp Asp Thr Ala Val Gln Pro Ser Phe Gln
         115                 120                 125            
 Val Gly Val Pro Leu Ser Thr Thr Pro Arg Ser Asn Ala Ser Val Asn
     130                 135                 140                
 Val Ser His Pro Ala Pro Gly Asp Trp Phe Val Ala Ala His Leu Pro
 145                 150                 155                 160
 Pro Ser Ser Gln Lys Ile Glu Leu Lys Gly Leu Ala Pro Thr Cys Ala
                 165                 170                 175    
 Tyr Val Phe Gln Pro Glu Leu Leu Val Thr Arg Val Val Glu Ile Ser
             180                 185                 190        
 Ile Met Glu Pro Asp Val Pro Leu Pro Gln Thr Leu Leu Ser His Pro
         195                 200                 205            
 Ser Tyr Leu Lys Val Phe Val Pro Asp Tyr Thr Arg Glu Leu Leu Leu
     210                 215                 220                
 Glu Leu Arg Asp Cys Val Ser Asn Gly Ser Leu Gly Cys Pro Val Arg
 225                 230                 235                 240
 Leu Thr Val Gly Pro Val Thr Leu Pro Ser Asn Phe Gln Lys Val Leu
                 245                 250                 255    
 Thr Cys Thr Gly Ala Pro Trp Pro Cys Arg Leu Leu Leu Pro Ser Pro
             260                 265                 270        
 Pro Trp Asp Arg Trp Leu Gln Val Thr Ala Glu Ser Leu Val Gly Pro
         275                 280                 285            
 Leu Gly Thr Val Ala Phe Ser Ala Val Ala Ala Leu Thr Ala Cys Arg
     290                 295                 300                
 Pro Arg Ser Val Thr Val Gln Pro Leu Leu Gln Ser Ser Gln Asn Gln
 305                 310                 315                 320
 Ser Phe Asn Ala Ser Ser Gly Leu Leu Ser Pro Ser Pro Asp His Gln
                 325                 330                 335    
 Asp Leu Gly Arg Ser Gly Arg Val Asp Arg Ser Pro Phe Cys Leu Thr
             340                 345                 350        
 Asn Tyr Pro Val Thr Arg Glu Asp Met Asp Val Val Ser Val His Phe
         355                 360                 365            
 Gln Pro Leu Asp Arg Val Ser Val Arg Val Cys Ser Asp Thr Pro Ser
     370                 375                 380                
 Val Met Arg Leu Arg Leu Asn Thr Gly Met Asp Ser Gly Gly Ser Leu
 385                 390                 395                 400
 Thr Ile Ser Leu Arg Ala Asn Lys Thr Glu Met Arg Asn Glu Thr Val
                 405                 410                 415    
 Val Val Ala Cys Val Asn Ala Ala Ser Pro Phe Leu Gly Phe Asn Thr
             420                 425                 430        
 Ser Leu Asn Cys Thr Thr Ala Phe Phe Gln Gly Tyr Pro Leu Ser Leu
         435                 440                 445            
 Ser Ala Trp Ser Arg Arg Ala Asn Leu Ile Ile Pro Tyr Pro Glu Thr
     450                 455                 460                
 Asp Asn Trp Tyr Leu Ser Leu Gln Leu Met Cys Pro Glu Asn Ala Glu
 465                 470                 475                 480
 Asp Cys Glu Gln Ala Val Val His Val Glu Thr Thr Leu Tyr Leu Val
                 485                 490                 495    
 Pro Cys Leu Asn Asp Cys Gly Pro Tyr Gly Gln Cys Leu Leu Leu Arg
             500                 505                 510        
 Arg His Ser Tyr Leu Tyr Ala Ser Cys Ser Cys Lys Ala Gly Trp Arg
         515                 520                 525            
 Gly Trp Ser Cys Thr Asp Asn Ser Thr Ala Gln Thr Val Ala Gln Gln
     530                 535                 540                
 Arg Ala Ala Thr Leu Leu Leu Thr Leu Ser Asn Leu Met Phe Leu Ala
 545                 550                 555                 560
 Pro Ile Ala Val Ser Val Arg Arg Phe Phe Leu Val Glu Ala Ser Val
                 565                 570                 575    
 Tyr Ala Tyr Thr Met Phe Phe Ser Thr Phe Tyr His Ala Cys Asp Gln
             580                 585                 590        
 Pro Gly Glu Ala Val Leu Cys Ile Leu Ser Tyr Asp Thr Leu Gln Tyr
         595                 600                 605            
 Cys Asp Phe Leu Gly Ser Gly Ala Ala Ile Trp Val Thr Ile Leu Cys
     610                 615                 620                
 Met Ala Arg Leu Lys Thr Val Leu Lys Tyr Val Leu Phe Leu Leu Gly
 625                 630                 635                 640
 Thr Leu Val Ile Ala Met Ser Leu Gln Leu Asp Arg Arg Gly Met Trp
                 645                 650                 655    
 Asn Met Leu Gly Pro Cys Leu Phe Ala Phe Val Ile Met Ala Ser Met
             660                 665                 670        
 Trp Ala Tyr Arg Cys Gly His Arg Arg Gln Cys Tyr Pro Thr Ser Trp
         675                 680                 685            
 Gln Arg Trp Ala Phe Tyr Leu Leu Pro Gly Val Ser Met Ala Ser Val
     690                 695                 700                
 Gly Ile Ala Ile Tyr Thr Ser Met Met Thr Ser Asp Asn Tyr Tyr Tyr
 705                 710                 715                 720
 Thr His Ser Ile Trp His Ile Leu Leu Ala Gly Ser Ala Ala Leu Leu
                 725                 730                 735    
 Leu Pro Pro Pro Asp Gln Pro Ala Glu Pro Trp Ala Cys Ser Gln Lys
             740                 745                 750        
 Phe Pro Cys His Tyr Gln Ile Cys Lys Asn Asp Arg Glu Glu Leu Tyr
         755                 760                 765            
 Ala Val Thr
     770    



      <210> 337
      <211> 395
      <212> PRT
      <213> Homo sapiens


      <400> 337
 Met Trp Leu Pro Arg Val Ser Ser Thr Ala Val Thr Ala Leu Leu Leu
   1               5                  10                  15    
 Ala Gln Thr Phe Leu Leu Leu Phe Leu Val Ser Arg Pro Gly Pro Ser
              20                  25                  30        
 Ser Pro Ala Gly Gly Glu Ala Arg Val His Val Leu Val Leu Ser Ser
          35                  40                  45            
 Trp Arg Ser Gly Ser Ser Phe Val Gly Gln Leu Phe Asn Gln His Pro
      50                  55                  60                
 Asp Val Phe Tyr Leu Met Glu Pro Ala Trp His Val Trp Thr Thr Leu
  65                  70                  75                  80
 Ser Gln Gly Ser Ala Ala Thr Leu His Met Ala Val Arg Asp Leu Val
                  85                  90                  95    
 Arg Ser Val Phe Leu Cys Asp Met Asp Val Phe Asp Ala Tyr Leu Pro
             100                 105                 110        
 Trp Arg Arg Asn Leu Ser Asp Leu Phe Gln Trp Ala Val Ser Arg Ala
         115                 120                 125            
 Leu Cys Ser Pro Pro Ala Cys Ser Ala Phe Pro Arg Gly Ala Ile Ser
     130                 135                 140                
 Ser Glu Ala Val Cys Lys Pro Leu Cys Ala Arg Gln Ser Phe Thr Leu
 145                 150                 155                 160
 Ala Arg Glu Ala Cys Arg Ser Tyr Ser His Val Val Leu Lys Glu Val
                 165                 170                 175    
 Arg Phe Phe Asn Leu Gln Val Leu Tyr Pro Leu Leu Ser Asp Pro Ala
             180                 185                 190        
 Leu Asn Leu Arg Ile Val His Leu Val Arg Asp Pro Arg Ala Val Leu
         195                 200                 205            
 Arg Ser Arg Glu Gln Thr Ala Lys Ala Leu Ala Arg Asp Asn Gly Ile
     210                 215                 220                
 Val Leu Gly Thr Asn Gly Thr Trp Val Glu Ala Asp Pro Gly Leu Arg
 225                 230                 235                 240
 Val Val Arg Glu Val Cys Arg Ser His Val Arg Ile Ala Glu Ala Ala
                 245                 250                 255    
 Thr Leu Lys Pro Pro Pro Phe Leu Arg Gly Arg Tyr Arg Leu Val Arg
             260                 265                 270        
 Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala Glu Ile Arg Ala Leu Tyr
         275                 280                 285            
 Ala Phe Thr Gly Leu Ser Leu Thr Pro Gln Leu Glu Ala Trp Ile His
     290                 295                 300                
 Asn Ile Thr His Gly Ser Gly Pro Gly Ala Arg Arg Glu Ala Phe Lys
 305                 310                 315                 320
 Thr Ser Ser Arg Asn Ala Leu Asn Val Ser Gln Ala Trp Arg His Ala
                 325                 330                 335    
 Leu Pro Phe Ala Lys Ile Arg Arg Val Gln Glu Leu Cys Ala Gly Ala
             340                 345                 350        
 Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr Ser Glu Asp Glu Gln Arg
         355                 360                 365            
 Asn Leu Ala Leu Asp Leu Val Leu Pro Arg Gly Leu Asn Gly Phe Thr
     370                 375                 380                
 Trp Ala Ser Ser Thr Ala Ser His Pro Arg Asn
 385                 390                 395



      <210> 338
      <211> 312
      <212> PRT
      <213> Homo sapiens


      <400> 338
 Met Glu Lys Trp Asn His Thr Ser Asn Asp Phe Ile Leu Leu Gly Leu
   1               5                  10                  15    
 Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu Leu Cys Leu Ile Ile Leu
              20                  25                  30        
 Ile Phe Phe Leu Ala Ser Val Gly Asn Ser Ala Met Ile His Leu Ile
          35                  40                  45            
 His Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln
      50                  55                  60                
 Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met
  65                  70                  75                  80
 Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu Gly Cys
                  85                  90                  95    
 Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu
             100                 105                 110        
 Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Ser
         115                 120                 125            
 Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met Met Cys Val Lys Met Ile
     130                 135                 140                
 Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val
 145                 150                 155                 160
 Phe Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asp His Phe
                 165                 170                 175    
 Phe Cys Asp Val Pro Ala Met Leu Leu Leu Ala Cys Thr Asp Thr Trp
             180                 185                 190        
 Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Phe
         195                 200                 205            
 Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly Arg Val Leu Phe Ala Val
     210                 215                 220                
 Tyr His Met His Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr Thr Ile
 225                 230                 235                 240
 Ser Thr His Leu Thr Val Val Ile Ser Tyr Tyr Ala Pro Phe Val Tyr
                 245                 250                 255    
 Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp Lys Ile
             260                 265                 270        
 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile
         275                 280                 285            
 Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Met Arg Arg Val Phe
     290                 295                 300                
 Gly Ile Phe Ser Phe Leu Lys Glu
 305                 310        



      <210> 339
      <211> 299
      <212> PRT
      <213> Homo sapiens


      <400> 339
 Met Glu Lys Trp Asn His Thr Ser Asn Asp Phe Ile Leu Leu Gly Leu
   1               5                  10                  15    
 Leu Pro Pro Asn Gln Thr Gly Ile Phe Leu Leu Cys Leu Ile Ile Leu
              20                  25                  30        
 Ile Phe Phe Leu Ala Ser Val Gly Asn Ser Ala Met Ile His Leu Ile
          35                  40                  45            
 His Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln
      50                  55                  60                
 Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met
  65                  70                  75                  80
 Ala Tyr Asn Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu Gly Cys
                  85                  90                  95    
 Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu
             100                 105                 110        
 Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His Ser
         115                 120                 125            
 Leu Tyr Tyr Pro Ile Arg Met Ser Lys Met Met Cys Val Lys Met Ile
     130                 135                 140                
 Gly Gly Ser Trp Thr Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val
 145                 150                 155                 160
 Phe Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asp His Phe
                 165                 170                 175    
 Phe Cys Asp Val Pro Ala Met Leu Leu Leu Ala Cys Thr Asp Thr Trp
             180                 185                 190        
 Val Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Phe
         195                 200                 205            
 Pro Phe Ile Gly Ile Thr Ser Ser Cys Gly Arg Val Leu Phe Ala Val
     210                 215                 220                
 Tyr His Met His Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr Thr Ile
 225                 230                 235                 240
 Ser Thr His Leu Thr Val Val Ile Ser Tyr Tyr Ala Pro Phe Val Tyr
                 245                 250                 255    
 Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp Lys Ile
             260                 265                 270        
 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile
         275                 280                 285            
 Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Leu
     290                 295                



      <210> 340
      <211> 848
      <212> PRT
      <213> Homo sapiens


      <400> 340
 Met Trp Leu Arg Leu Gly Pro Pro Ser Leu Ser Leu Ser Pro Lys Pro
   1               5                  10                  15    
 Thr Val Gly Arg Ser Leu Cys Leu Thr Leu Trp Phe Leu Ser Leu Ala
              20                  25                  30        
 Leu Arg Ala Ser Thr Gln Ala Pro Ala Pro Thr Val Asn Thr His Phe
          35                  40                  45            
 Gly Lys Leu Arg Gly Ala Arg Val Pro Leu Pro Ser Glu Ile Leu Gly
      50                  55                  60                
 Pro Val Asp Gln Tyr Leu Gly Val Pro Tyr Ala Ala Pro Pro Ile Gly
  65                  70                  75                  80
 Glu Lys Arg Phe Leu Pro Pro Glu Pro Pro Pro Ser Trp Ser Gly Ile
                  85                  90                  95    
 Arg Asn Ala Thr His Phe Pro Pro Val Cys Pro Gln Asn Ile His Thr
             100                 105                 110        
 Ala Val Pro Glu Val Met Leu Pro Val Trp Phe Thr Ala Asn Leu Asp
         115                 120                 125            
 Ile Val Ala Thr Tyr Ile Gln Glu Pro Asn Glu Asp Cys Leu Tyr Leu
     130                 135                 140                
 Asn Val Tyr Val Pro Thr Glu Asp Val Lys Arg Ile Ser Lys Glu Cys
 145                 150                 155                 160
 Ala Arg Lys Pro Asn Lys Lys Ile Cys Arg Lys Gly Gly Ser Gly Ala
                 165                 170                 175    
 Lys Lys Gln Gly Glu Asp Leu Ala Asp Asn Asp Gly Asp Glu Asp Glu
             180                 185                 190        
 Asp Ile Arg Asp Ser Gly Ala Lys Pro Val Met Val Tyr Ile His Gly
         195                 200                 205            
 Gly Ser Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu
     210                 215                 220                
 Ala Ser Tyr Gly Asn Val Ile Val Ile Thr Leu Asn Tyr Arg Val Gly
 225                 230                 235                 240
 Val Leu Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr
                 245                 250                 255    
 Gly Leu Leu Asp Gln Ile Gln Ala Leu Arg Trp Val Ser Glu Asn Ile
             260                 265                 270        
 Ala Phe Phe Gly Gly Asp Pro Arg Arg Ile Thr Val Phe Gly Ser Gly
         275                 280                 285            
 Ile Gly Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His His Ser Glu
     290                 295                 300                
 Gly Leu Phe Gln Arg Ala Ile Ile Gln Ser Gly Ser Ala Leu Ser Ser
 305                 310                 315                 320
 Trp Ala Val Asn Tyr Gln Pro Val Lys Tyr Thr Ser Leu Leu Ala Asp
                 325                 330                 335    
 Lys Val Gly Cys Asn Val Leu Asp Thr Val Asp Met Val Asp Cys Leu
             340                 345                 350        
 Arg Gln Lys Ser Ala Lys Glu Leu Val Glu Gln Asp Ile Gln Pro Ala
         355                 360                 365            
 Arg Tyr His Val Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro
     370                 375                 380                
 Asp Asp Pro Glu Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp
 385                 390                 395                 400
 Ile Met Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Glu Gly
                 405                 410                 415    
 Val Val Asp Pro Glu Asp Gly Val Ser Gly Thr Asp Phe Asp Tyr Ser
             420                 425                 430        
 Val Ser Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp
         435                 440                 445            
 Thr Leu Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Arg
     450                 455                 460                
 Asp Asn Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp
 465                 470                 475                 480
 His Gln Trp Val Glu Pro Ser Val Val Thr Ala Asp Leu His Ala Arg
                 485                 490                 495    
 Tyr Gly Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser
             500                 505                 510        
 Leu Met Lys Pro Ala Trp Ser Asp Ala Ala His Gly Asp Glu Val Pro
         515                 520                 525            
 Tyr Val Phe Gly Val Pro Met Val Gly Pro Thr Asp Leu Phe Pro Cys
     530                 535                 540                
 Asn Phe Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr
 545                 550                 555                 560
 Trp Thr Asn Phe Ala Lys Thr Gly Asp Pro Asn Lys Pro Val Pro Gln
                 565                 570                 575    
 Asp Thr Lys Phe Ile His Thr Lys Ala Asn Arg Phe Glu Glu Val Ala
             580                 585                 590        
 Trp Ser Lys Tyr Asn Pro Arg Asp Gln Leu Tyr Leu His Ile Gly Leu
         595                 600                 605            
 Lys Pro Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp
     610                 615                 620                
 Lys His Leu Val Pro His Leu Tyr Asn Leu His Asp Met Phe His Tyr
 625                 630                 635                 640
 Thr Ser Thr Thr Thr Lys Val Pro Pro Pro Asp Thr Thr His Ser Ser
                 645                 650                 655    
 His Ile Thr Arg Arg Pro Asn Gly Lys Thr Trp Ser Thr Lys Arg Pro
             660                 665                 670        
 Ala Ile Ser Pro Ala Tyr Ser Asn Glu Asn Ala Gln Gly Ser Trp Asn
         675                 680                 685            
 Gly Asp Gln Asp Ala Gly Pro Leu Leu Val Glu Asn Pro Arg Asp Tyr
     690                 695                 700                
 Ser Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe
 705                 710                 715                 720
 Leu Asn Val Leu Ala Phe Ala Ala Leu Tyr Tyr Arg Lys Asp Lys Arg
                 725                 730                 735    
 Arg Gln Glu Pro Leu Arg Gln Pro Ser Pro Gln Arg Gly Ala Gly Ala
             740                 745                 750        
 Pro Glu Leu Gly Ala Ala Pro Glu Glu Glu Leu Ala Ala Leu Gln Leu
         755                 760                 765            
 Gly Pro Thr His His Glu Cys Glu Ala Gly Pro Pro His Asp Thr Leu
     770                 775                 780                
 Arg Leu Thr Ala Leu Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro
 785                 790                 795                 800
 Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn
                 805                 810                 815    
 Ser Leu Val Gly Leu Gln Thr Leu His Pro Tyr Asn Thr Phe Ala Ala
             820                 825                 830        
 Gly Phe Asn Ser Thr Gly Leu Pro His Ser His Ser Thr Thr Arg Val
         835                 840                 845            





      <210> 341
      <211> 936
      <212> PRT
      <213> Homo sapiens


      <400> 341
 Met Val Cys Ser Ala Ala Pro Leu Leu Leu Leu Ala Thr Thr Leu Pro
   1               5                  10                  15    
 Leu Leu Gly Ser Pro Val Ala Gln Ala Ser Gln Pro Val Ser Glu Thr
              20                  25                  30        
 Gly Val Arg Pro Arg Glu Gly Leu Gln Arg Arg Gln Trp Gly Pro Leu
          35                  40                  45            
 Ile Gly Arg Asp Lys Ala Trp Asn Glu Arg Ile Asp Arg Pro Phe Pro
      50                  55                  60                
 Ala Cys Pro Ile Pro Leu Ser Ser Ser Phe Gly Arg Trp Pro Lys Gly
  65                  70                  75                  80
 Gln Thr Met Trp Ala Gln Thr Ser Thr Leu Thr Leu Thr Glu Glu Glu
                  85                  90                  95    
 Leu Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly Ser Gly Gln Leu Leu
             100                 105                 110        
 Asp Gln Glu Asn Gly Ala Gly Glu Cys Asn Val Asn His Lys Gly Asn
         115                 120                 125            
 Phe Tyr Cys Ala Cys Leu Ser Gly Tyr Gln Trp Asn Thr Ser Ile Cys
     130                 135                 140                
 Leu His Tyr Pro Pro Cys Gln Ser Leu His Asn His Gln Pro Cys Gly
 145                 150                 155                 160
 Cys Leu Val Phe Ser His Pro Glu Pro Gly Tyr Cys Gln Leu Leu Pro
                 165                 170                 175    
 Pro Gly Glu Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn
             180                 185                 190        
 Leu Tyr Glu Val Val Arg Val Pro Leu Lys Ala Thr Asp Val Ala Arg
         195                 200                 205            
 Leu Pro Tyr Gln Leu Ser Ile Ser Cys Ala Thr Ser Pro Gly Phe Gln
     210                 215                 220                
 Leu Ser Cys Cys Ile Pro Ser Thr Asn Leu Ala Tyr Thr Ala Ala Trp
 225                 230                 235                 240
 Ser Pro Gly Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser
                 245                 250                 255    
 Gln Cys Phe Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp Thr Thr
             260                 265                 270        
 Tyr Ala Cys Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro
         275                 280                 285            
 Ile Ser Ile Thr Ile Ile Gln Asp Gly Asp Ile Thr Cys Pro Glu Asp
     290                 295                 300                
 Ala Ser Val Leu Thr Trp Asn Val Thr Lys Ala Gly His Val Ala Gln
 305                 310                 315                 320
 Ala Pro Cys Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly
                 325                 330                 335    
 Ala Asp Gly Val Trp Gly Pro Val His Ser Ser Cys Thr Asp Ala Arg
             340                 345                 350        
 Leu Leu Ala Leu Phe Thr Arg Thr Lys Leu Leu Gln Ala Gly Gln Gly
         355                 360                 365            
 Ser Pro Ala Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln
     370                 375                 380                
 Ala Ala Glu Ala Ser Ser Pro Ser Asp Leu Leu Thr Leu Leu Ser Thr
 385                 390                 395                 400
 Met Lys Tyr Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp
                 405                 410                 415    
 Arg Arg Ala Leu Lys Asn Leu Leu Ile Ala Thr Asp Lys Val Leu Asp
             420                 425                 430        
 Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp
         435                 440                 445            
 Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu
     450                 455                 460                
 Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu
 465                 470                 475                 480
 Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser
                 485                 490                 495    
 Phe Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu
             500                 505                 510        
 Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val
         515                 520                 525            
 Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu
     530                 535                 540                
 Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile
 545                 550                 555                 560
 Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe
                 565                 570                 575    
 Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His Ser Leu
             580                 585                 590        
 Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val
         595                 600                 605            
 Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala
     610                 615                 620                
 Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu
 625                 630                 635                 640
 Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu
                 645                 650                 655    
 Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn
             660                 665                 670        
 Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val Phe Cys
         675                 680                 685            
 Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro
     690                 695                 700                
 Gly Pro Arg Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe
 705                 710                 715                 720
 Leu Tyr Leu Ala Thr Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu
                 725                 730                 735    
 Ala His Gln Leu Leu Phe Val Phe His Gln Leu Ala Lys His Arg Val
             740                 745                 750        
 Leu Pro Leu Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala
         755                 760                 765            
 Gly Val Thr Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu
     770                 775                 780                
 Gly Glu Cys Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Thr Phe Val
 785                 790                 795                 800
 Gly Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met
                 805                 810                 815    
 Ala Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala
             820                 825                 830        
 Glu Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu
         835                 840                 845            
 Thr Pro Ile Phe Gly Leu Thr Trp Gly Leu Gly Leu Ala Thr Leu Leu
     850                 855                 860                
 Glu Glu Val Ser Thr Val Pro His Tyr Ile Phe Thr Ile Leu Asn Thr
 865                 870                 875                 880
 Leu Gln Gly Val Phe Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys
                 885                 890                 895    
 Ile Gln Glu Ala Leu Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser
             900                 905                 910        
 Ser Thr Ile Ser Leu Ala Thr Asn Glu Gly Cys Ile Leu Glu His Ser
         915                 920                 925            
 Lys Gly Gly Ser Asp Thr Ala Arg
     930                 935    



      <210> 342
      <211> 249
      <212> PRT
      <213> Homo sapiens


      <400> 342
 Met Glu Thr Thr Asn His Ser Ala Val Thr Glu Phe Phe Leu Val Gly
   1               5                  10                  15    
 Leu Ser Gln Tyr Pro Glu Leu Gln Leu Phe Leu Phe Leu Leu Cys Leu
              20                  25                  30        
 Ile Met Tyr Met Ile Ile Leu Leu Gly Asn Ser Phe Leu Ile Ile Ile
          35                  40                  45            
 Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly
      50                  55                  60                
 Asn Leu Ser Phe Leu Gly Ile Cys Tyr Thr Ser Ser Ser Ile Pro Pro
  65                  70                  75                  80
 Met Leu Ile Ile Phe Val Ser Glu Arg Lys Ser Ile Ser Phe Ile Gly
                  85                  90                  95    
 Cys Ala Leu Gln Met Val Val Ser Leu Gly Leu Gly Ser Ile Glu Cys
             100                 105                 110        
 Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn
         115                 120                 125            
 Pro Leu Arg Tyr Ser Ile Ile Met Asn Arg Val Leu Tyr Val Gln Met
     130                 135                 140                
 Ala Ala Trp Ser Trp Ile Ile Gly Cys Leu Thr Ser Leu Leu Arg Thr
 145                 150                 155                 160
 Val Leu Thr Met Met Leu Pro Phe Cys Gly Asn Asn Ile Ile Asp His
                 165                 170                 175    
 Leu Thr Ser His Leu Thr Val Val Ile Leu Phe Tyr Gly Ser Val Leu
             180                 185                 190        
 Phe Met His Met Lys Pro Lys Ser Lys Phe Thr Thr Ala Ser Asp Glu
         195                 200                 205            
 Ile Ile Gly Leu Ser Tyr Glu Val Ile Thr Pro Met Asn Pro Ile Ile
     210                 215                 220                
 Tyr Ser Leu Arg Asn Lys Glu Ile Lys Glu Ala Val Lys Lys Ile Leu
 225                 230                 235                 240
 Ser Arg His Val His Leu Trp Lys Ile
                 245                



      <210> 343
      <211> 307
      <212> PRT
      <213> Homo sapiens


      <400> 343
 Met His Val Cys Leu Cys Val Trp Val His Ile Cys Val Cys Val Pro
   1               5                  10                  15    
 Val Cys Val Gly Ala His Leu Cys Val Trp Val His Ile Cys Val Cys
              20                  25                  30        
 Val Arg Leu Cys Val Trp Val His Ile Cys Val Cys Val Cys Leu Cys
          35                  40                  45            
 Val Cys Leu Cys Val Trp Val Pro Val Cys Val Gly His Ile Cys Val
      50                  55                  60                
 Cys Val Cys Leu Cys Val Gly Ala His Leu Cys Val Cys Leu Cys Val
  65                  70                  75                  80
 Cys Ala Cys Val Trp Gly Cys Thr Phe Val Cys Ala Pro Val Cys Gly
                  85                  90                  95    
 Gly Ala His Leu Cys Val Arg Leu Cys Val Trp Val His Ile Cys Val
             100                 105                 110        
 Cys Val Arg Leu Cys Gly Cys Leu Cys Val Cys Gly Ala His Leu Cys
         115                 120                 125            
 Val Cys Val Cys Leu Cys Val Gly Ala His Leu Cys Val Cys Leu Cys
     130                 135                 140                
 Val Cys Ala Cys Val Trp Gly Cys Thr Phe Val Cys Val Cys Ala Cys
 145                 150                 155                 160
 Val Trp Gly Cys Thr Phe Val Cys Val Cys Ala Cys Val Cys Gly Cys
                 165                 170                 175    
 Thr Phe Val Cys Val Cys Ala Cys Val Cys Gly Cys Thr Phe Val Cys
             180                 185                 190        
 Val Cys Leu Cys Val Trp Val His Ile Cys Val Cys Val Cys Leu Cys
         195                 200                 205            
 Val Trp Val His Ile Cys Val Cys Ala Cys Val Trp Val His Ile Cys
     210                 215                 220                
 Val Cys Val Pro Val Cys Val Cys Leu Cys Val Trp Val His Ile Cys
 225                 230                 235                 240
 Val Cys Val Cys Leu Cys Val Trp Val His Ile Cys Val Cys Val Cys
                 245                 250                 255    
 Ala Cys Val Cys Val Ala Gly Pro Gly Cys Gln Thr Leu Asn Lys Arg
             260                 265                 270        
 Arg Lys Thr Ser Val Phe Ile Leu Leu Val Gly Arg Trp Ser Arg Asn
         275                 280                 285            
 Thr Trp Met Glu Ser Ala Leu Gln Glu Arg Cys Leu Cys Leu Trp Arg
     290                 295                 300                
 Gly Pro Trp
 305        



      <210> 344
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 344
 Met Ser Ile Thr Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile
   1               5                  10                  15    
 Leu Leu Gly Phe Thr Asp His Pro Glu Leu Gln Ala Leu Leu Phe Val
              20                  25                  30        
 Thr Phe Leu Gly Ile Tyr Leu Thr Thr Leu Ala Trp Asn Leu Ala Leu
          35                  40                  45            
 Ile Phe Leu Ile Arg Gly Asp Thr His Leu His Thr Pro Met Tyr Phe
      50                  55                  60                
 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Ala Val
  65                  70                  75                  80
 Ala Pro Asn Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser
                  85                  90                  95    
 Phe Val Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Gly Met Gly Leu
             100                 105                 110        
 Ser Glu Cys Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala
         115                 120                 125            
 Ile Ser Ser Pro Leu Leu Tyr Pro Thr Ile Met Thr Gln Gly Leu Cys
     130                 135                 140                
 Thr Arg Met Val Val Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu
 145                 150                 155                 160
 Ile Gln Ala Ser Ser Ile Phe Arg Leu His Phe Cys Gly Pro Asn Ile
                 165                 170                 175    
 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys
             180                 185                 190        
 Ser Asp Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Val Thr
         195                 200                 205            
 Val Gly Gly Thr Ser Phe Leu Gln Leu Leu Ile Ser Tyr Gly Tyr Ile
     210                 215                 220                
 Val Ser Ala Val Leu Lys Ile Pro Ser Ala Glu Gly Arg Trp Lys Ala
 225                 230                 235                 240
 Cys Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly
                 245                 250                 255    
 Thr Ala Leu Phe Val Tyr Leu Arg Pro Ser Ser Ser Tyr Leu Leu Gly
             260                 265                 270        
 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu
         275                 280                 285            
 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu
     290                 295                 300                
 Trp Lys Val Leu Glu Arg Lys Lys Val Phe Ser
 305                 310                 315



      <210> 345
      <211> 798
      <212> PRT
      <213> Homo sapiens


      <400> 345
 Met Gly Ser Arg Phe Leu Leu Val Leu Leu Ser Gly Leu Thr Val Leu
   1               5                  10                  15    
 Leu Ala Leu Pro Gly Ser Glu Ala Lys Asn Ser Gly Ala Ser Cys Pro
              20                  25                  30        
 Pro Cys Pro Lys Tyr Ala Ser Cys His Asn Ser Thr His Cys Thr Cys
          35                  40                  45            
 Glu Asp Gly Phe Arg Ala Arg Ser Gly Arg Thr Tyr Phe His Asp Ser
      50                  55                  60                
 Ser Glu Lys Cys Glu Asp Ile Asn Glu Cys Glu Thr Gly Leu Ala Lys
  65                  70                  75                  80
 Cys Lys Tyr Lys Ala Tyr Cys Arg Asn Lys Val Gly Gly Tyr Ile Cys
                  85                  90                  95    
 Ser Cys Leu Val Lys Tyr Thr Leu Phe Asn Phe Leu Ala Gly Ile Ile
             100                 105                 110        
 Asp Tyr Asp His Pro Asp Cys Tyr Glu Asn Ser Gly Glu Asn Asn Ser
         115                 120                 125            
 Gln Gly Thr Thr Gln Ser Asn Val Asp Ile Trp Val Ser Gly Val Lys
     130                 135                 140                
 Pro Gly Phe Gly Lys Gln Leu Glu Asn Leu Arg Arg Asn Gly Ser Arg
 145                 150                 155                 160
 Glu Asp Phe Ala Arg Arg Ala Thr Gln Leu Ile Gln Ser Val Glu Leu
                 165                 170                 175    
 Ser Ile Trp Asn Ala Ser Phe Ala Ser Pro Gly Lys Gly Gln Ile Ser
             180                 185                 190        
 Glu Phe Asp Ile Val Tyr Glu Thr Lys Arg Cys Asn Glu Thr Arg Glu
         195                 200                 205            
 Asn Ala Phe Leu Glu Ala Gly Asn Asn Thr Met Asp Ile Asn Cys Ala
     210                 215                 220                
 Asp Ala Leu Lys Gly Asn Leu Arg Asp Trp Lys Thr Asn Val Leu Tyr
 225                 230                 235                 240
 Lys Val Gln Arg Val Asn Met Leu Gly Leu Leu Phe Gln Met Thr Phe
                 245                 250                 255    
 Val Ile Thr Thr Gln Leu Cys His Gln Ser Val Lys Ala Ala Ile Asp
             260                 265                 270        
 Asp Val Ser Val Lys Glu Glu His Cys Ser Cys Pro Ile Thr Tyr Gln
         275                 280                 285            
 Ser Leu Gly Asp Ile Leu Asn Ala Ser Phe Phe Ser Lys Arg Lys Gly
     290                 295                 300                
 Met Gln Glu Val Lys Leu Asn Ser Tyr Val Val Ser Gly Thr Val Gly
 305                 310                 315                 320
 Leu Lys Glu Lys Ile Ser Leu Ser Glu Pro Val Phe Leu Thr Phe Arg
                 325                 330                 335    
 His Asn Gln Pro Gly Asp Lys Arg Thr Lys His Ile Cys Val Tyr Trp
             340                 345                 350        
 Glu Gly Ser Glu Gly Gly Arg Trp Ser Thr Glu Gly Cys Ser His Val
         355                 360                 365            
 His Ser Asn Gly Ser Tyr Thr Lys Cys Lys Cys Phe His Leu Ser Ser
     370                 375                 380                
 Phe Ala Val Leu Val Ala Leu Ala Pro Lys Glu Asp Pro Val Leu Thr
 385                 390                 395                 400
 Val Ile Thr Gln Val Gly Leu Thr Ile Ser Leu Leu Cys Leu Phe Leu
                 405                 410                 415    
 Ala Ile Leu Thr Phe Leu Leu Cys Arg Pro Ile Gln Asn Thr Ser Thr
             420                 425                 430        
 Ser Leu His Leu Glu Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu
         435                 440                 445            
 Phe Leu Thr Gly Ile Asn Arg Thr Glu Pro Glu Val Leu Cys Ser Ile
     450                 455                 460                
 Ile Ala Gly Leu Leu His Phe Leu Tyr Leu Ala Cys Phe Thr Trp Met
 465                 470                 475                 480
 Leu Leu Glu Gly Leu His Leu Phe Leu Thr Val Arg Asn Leu Lys Val
                 485                 490                 495    
 Ala Asn Tyr Thr Ser Thr Gly Arg Phe Lys Lys Arg Phe Met Tyr Pro
             500                 505                 510        
 Val Gly Tyr Gly Ile Pro Ala Val Ile Ile Ala Val Ser Ala Ile Val
         515                 520                 525            
 Gly Pro Gln Asn Tyr Gly Thr Phe Thr His Cys Trp Leu Lys Leu Asp
     530                 535                 540                
 Lys Gly Phe Ile Trp Ser Phe Met Gly Pro Val Ala Val Ile Ile Leu
 545                 550                 555                 560
 Ile Asn Leu Val Phe Tyr Phe Gln Val Leu Trp Ile Leu Arg Ser Lys
                 565                 570                 575    
 Leu Ser Ser Leu Asn Lys Glu Val Ser Thr Ile Gln Asp Thr Arg Val
             580                 585                 590        
 Met Thr Phe Lys Ala Ile Ser Gln Leu Phe Ile Leu Gly Cys Ser Trp
         595                 600                 605            
 Gly Leu Gly Phe Phe Met Val Glu Glu Val Gly Lys Thr Ile Gly Ser
     610                 615                 620                
 Ile Ile Ala Tyr Ser Phe Thr Ile Ile Asn Thr Leu Gln Gly Val Leu
 625                 630                 635                 640
 Leu Phe Val Val His Cys Leu Leu Asn Arg Gln Ile Asn Ser Leu Leu
                 645                 650                 655    
 Leu Thr Trp Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn
             660                 665                 670        
 Ala Glu Val Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala
         675                 680                 685            
 Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe
     690                 695                 700                
 Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile Ile
 705                 710                 715                 720
 Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn
                 725                 730                 735    
 Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr Lys
             740                 745                 750        
 Pro Ser Ser Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met Pro
         755                 760                 765            
 Ser Ala Ser Lys Thr Ser Ile Ile Gly Tyr Ile Ala Pro Thr Met Val
     770                 775                 780                
 Gly Gln Cys Val Thr Phe Gln Met Glu His Phe Leu Phe Ser
 785                 790                 795            



      <210> 346
      <211> 702
      <212> PRT
      <213> Homo sapiens


      <400> 346
 Met Gly Ser Arg Phe Leu Leu Val Leu Leu Ser Gly Leu Thr Val Leu
   1               5                  10                  15    
 Leu Ala Leu Pro Gly Ser Glu Ala Lys Asn Ser Gly Glu Asn Asn Ser
              20                  25                  30        
 Gln Gly Thr Thr Gln Ser Asn Val Asp Ile Trp Val Ser Gly Val Lys
          35                  40                  45            
 Pro Gly Phe Gly Lys Gln Leu Glu Asn Leu Arg Arg Asn Gly Ser Arg
      50                  55                  60                
 Glu Asp Phe Ala Arg Arg Ala Thr Gln Leu Ile Gln Ser Val Glu Leu
  65                  70                  75                  80
 Ser Ile Trp Asn Ala Ser Phe Ala Ser Pro Gly Lys Gly Gln Ile Ser
                  85                  90                  95    
 Glu Phe Asp Ile Val Tyr Glu Thr Lys Arg Cys Asn Glu Thr Arg Glu
             100                 105                 110        
 Asn Ala Phe Leu Glu Ala Gly Asn Asn Thr Met Asp Ile Asn Cys Ala
         115                 120                 125            
 Asp Ala Leu Lys Gly Asn Leu Arg Asp Trp Lys Thr Asn Val Leu Tyr
     130                 135                 140                
 Lys Val Gln Arg Val Asn Met Leu Gly Leu Leu Phe Gln Met Thr Phe
 145                 150                 155                 160
 Val Ile Thr Thr Gln Leu Cys His Gln Ser Val Lys Ala Ala Ile Asp
                 165                 170                 175    
 Asp Val Ser Val Lys Glu Glu His Cys Ser Cys Pro Ile Thr Tyr Gln
             180                 185                 190        
 Ser Leu Gly Asp Ile Leu Asn Ala Ser Phe Phe Ser Lys Arg Lys Gly
         195                 200                 205            
 Met Gln Glu Val Lys Leu Asn Ser Tyr Val Val Ser Gly Thr Val Gly
     210                 215                 220                
 Leu Lys Glu Lys Ile Ser Leu Ser Glu Pro Val Phe Leu Thr Phe Arg
 225                 230                 235                 240
 His Asn Gln Pro Gly Asp Lys Arg Thr Lys His Ile Cys Val Tyr Trp
                 245                 250                 255    
 Glu Gly Ser Glu Gly Gly Arg Trp Ser Thr Glu Gly Cys Ser His Val
             260                 265                 270        
 His Ser Asn Gly Ser Tyr Thr Lys Cys Lys Cys Phe His Leu Ser Ser
         275                 280                 285            
 Phe Ala Val Leu Val Ala Leu Ala Pro Lys Glu Asp Pro Val Leu Thr
     290                 295                 300                
 Val Ile Thr Gln Val Gly Leu Thr Ile Ser Leu Leu Cys Leu Phe Leu
 305                 310                 315                 320
 Ala Ile Leu Thr Phe Leu Leu Cys Arg Pro Ile Gln Asn Thr Ser Thr
                 325                 330                 335    
 Ser Leu His Leu Glu Leu Ser Leu Cys Leu Phe Leu Ala His Leu Leu
             340                 345                 350        
 Phe Leu Thr Gly Ile Asn Arg Thr Glu Pro Glu Val Leu Cys Ser Ile
         355                 360                 365            
 Ile Ala Gly Leu Leu His Phe Leu Tyr Leu Ala Cys Phe Thr Trp Met
     370                 375                 380                
 Leu Leu Glu Gly Leu His Leu Phe Leu Thr Val Arg Asn Leu Lys Val
 385                 390                 395                 400
 Ala Asn Tyr Thr Ser Thr Gly Arg Phe Lys Lys Arg Phe Met Tyr Pro
                 405                 410                 415    
 Val Gly Tyr Gly Ile Pro Ala Val Ile Ile Ala Val Ser Ala Ile Val
             420                 425                 430        
 Gly Pro Gln Asn Tyr Gly Thr Phe Thr His Cys Trp Leu Lys Leu Asp
         435                 440                 445            
 Lys Gly Phe Ile Trp Ser Phe Met Gly Pro Val Ala Val Ile Ile Leu
     450                 455                 460                
 Ile Asn Leu Val Phe Tyr Phe Gln Val Leu Trp Ile Leu Arg Ser Lys
 465                 470                 475                 480
 Leu Ser Ser Leu Asn Lys Glu Val Ser Thr Ile Gln Asp Thr Arg Val
                 485                 490                 495    
 Met Thr Phe Lys Ala Ile Ser Gln Leu Phe Ile Leu Gly Cys Ser Trp
             500                 505                 510        
 Gly Leu Gly Phe Phe Met Val Glu Glu Val Gly Lys Thr Ile Gly Ser
         515                 520                 525            
 Ile Ile Ala Tyr Ser Phe Thr Ile Ile Asn Thr Leu Gln Gly Val Leu
     530                 535                 540                
 Leu Phe Val Val His Cys Leu Leu Asn Arg Gln Ile Asn Ser Leu Leu
 545                 550                 555                 560
 Leu Thr Trp Thr Leu Trp Ile Leu Arg Gln Arg Leu Ser Ser Val Asn
                 565                 570                 575    
 Ala Glu Val Ser Thr Leu Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala
             580                 585                 590        
 Phe Ala Gln Leu Phe Ile Leu Gly Cys Ser Trp Val Leu Gly Ile Phe
         595                 600                 605            
 Gln Ile Gly Pro Val Ala Gly Val Met Ala Tyr Leu Phe Thr Ile Ile
     610                 615                 620                
 Asn Ser Leu Gln Gly Ala Phe Ile Phe Leu Ile His Cys Leu Leu Asn
 625                 630                 635                 640
 Gly Gln Val Arg Glu Glu Tyr Lys Arg Trp Ile Thr Gly Lys Thr Lys
                 645                 650                 655    
 Pro Ser Ser Gln Ser Gln Thr Ser Arg Ile Leu Leu Ser Ser Met Pro
             660                 665                 670        
 Ser Ala Ser Lys Thr Ser Ile Ile Gly Tyr Ile Ala Pro Thr Met Val
         675                 680                 685            
 Gly Gln Cys Val Thr Phe Gln Met Glu His Phe Leu Phe Ser
     690                 695                 700        



      <210> 347
      <211> 368
      <212> PRT
      <213> Homo sapiens


      <400> 347
 Met Glu Gly Leu Val Phe Leu Asn Ala Leu Ala Thr Arg Leu Leu Phe
   1               5                  10                  15    
 Leu Leu His Ser Leu Val Gly Val Trp Arg Val Thr Glu Val Lys Lys
              20                  25                  30        
 Glu Pro Arg Tyr Trp Leu Leu Ala Leu Leu Asn Leu Leu Leu Phe Leu
          35                  40                  45            
 Glu Thr Ala Leu Thr Leu Lys Phe Lys Arg Gly Arg Gly Tyr Lys Trp
      50                  55                  60                
 Phe Ser Pro Ala Ile Phe Leu Tyr Leu Ile Ser Ile Val Pro Ser Leu
  65                  70                  75                  80
 Trp Leu Leu Glu Leu His His Glu Thr Gln Tyr Cys Ser Ile Gln Ala
                  85                  90                  95    
 Glu Gly Thr Ser Gln Asn Thr Ser Arg Lys Glu Asp Phe Asn Gln Thr
             100                 105                 110        
 Leu Thr Ser Asn Glu Gln Thr Ser Arg Ala Asp Asp Leu Ile Glu Thr
         115                 120                 125            
 Ala Lys Val Phe Val Asn Asn Leu Ser Thr Val Cys Glu Lys Val Trp
     130                 135                 140                
 Thr Leu Gly Leu His Gln Thr Phe Leu Leu Met Leu Ile Ile Gly Arg
 145                 150                 155                 160
 Trp Leu Leu Pro Ile Gly Gly Gly Ile Thr Arg Asp Gln Leu Ser Gln
                 165                 170                 175    
 Leu Leu Leu Met Phe Val Gly Thr Ala Ala Asp Ile Leu Glu Phe Thr
             180                 185                 190        
 Ser Glu Thr Leu Glu Glu Gln Asn Val Arg Asn Ser Pro Ala Leu Val
         195                 200                 205            
 Tyr Ala Ile Leu Val Ile Trp Thr Trp Ser Met Leu Gln Phe Pro Leu
     210                 215                 220                
 Asp Leu Ala Val Gln Asn Val Val Cys Pro Val Ser Val Thr Glu Arg
 225                 230                 235                 240
 Gly Phe Pro Ser Leu Phe Phe Cys Gln Tyr Ser Ala Asp Leu Trp Asn
                 245                 250                 255    
 Ile Gly Ile Ser Ala Phe Ile Gln Asp Gly Pro Phe Leu Val Val Arg
             260                 265                 270        
 Leu Ile Leu Met Thr Tyr Phe Lys Val Ile Asn Gln Met Leu Val Phe
         275                 280                 285            
 Phe Ala Ala Lys Asn Phe Leu Val Val Val Leu Gln Leu Tyr Arg Leu
     290                 295                 300                
 Val Val Leu Ala Leu Ala Val Arg Ala Ser Leu Arg Ser Gln Ser Glu
 305                 310                 315                 320
 Gly Leu Lys Gly Glu His Gly Cys Arg Ala Gln Thr Ser Glu Ser Gly
                 325                 330                 335    
 Pro Ser Gln Arg Asp Trp Gln Asn Glu Ser Lys Glu Gly Leu Ala Ile
             340                 345                 350        
 Pro Leu Arg Gly Ser Pro Val Thr Ser Asp Asp Ser His His Thr Pro
         355                 360                 365            





      <210> 348
      <211> 87
      <212> PRT
      <213> Homo sapiens


      <400> 348
 Met Gly Glu Thr Gln Val Leu Leu Pro Arg Ser Ser Gln Gly Pro Arg
   1               5                  10                  15    
 Arg Arg Met Leu Pro Pro Phe Ser Leu Val Tyr Thr His Phe Leu Val
              20                  25                  30        
 Ala Ser Leu Leu Pro Val Ile Leu Ala Val Phe Pro Asp Ser Ala Gln
          35                  40                  45            
 Ile Val Pro Leu Leu Lys Pro Ile Pro Arg Pro Gln Pro Glu Val Ile
      50                  55                  60                
 Phe Pro Ser Ser Glu Leu Leu Glu Gln Leu Leu Ser Val Gln Phe Val
  65                  70                  75                  80
 Trp Gln Ala His Thr Val Ala
                  85        



      <210> 349
      <211> 170
      <212> PRT
      <213> Homo sapiens


      <400> 349
 Met Asn Val Arg Met Phe Ser Leu Met Val Gly Ile Phe Ser Val Leu
   1               5                  10                  15    
 Asn Thr Thr Gln Phe Phe Ile Phe Asp Leu Asn Gln Lys Thr His Ile
              20                  25                  30        
 Cys Tyr Glu Ala Lys Phe Ser Ile Tyr Val Asp Ser Lys Ser Glu Leu
          35                  40                  45            
 Val Thr Trp Thr Leu Phe His Arg Ala Asn Ile Ser Thr Gly Leu Ser
      50                  55                  60                
 Leu Thr Thr Ile Ile Ile Gly Cys Phe Leu Leu Tyr Cys Ile His Lys
  65                  70                  75                  80
 Asn Ile Tyr Met Gly Leu Leu Ile Tyr Ala Met Trp Ile Ile Thr Tyr
                  85                  90                  95    
 Glu Leu Ile Asn Phe Ser Ile Val Leu Leu Leu Asn Gly Ile Ile Lys
             100                 105                 110        
 Asp His Phe Lys Met Leu Ser Tyr Leu His Trp Ile Phe Gln Ile Ser
         115                 120                 125            
 His Met Leu Leu His Phe Phe Cys Leu Pro Phe Ile Val Lys His Ala
     130                 135                 140                
 Tyr Asn Leu Tyr Lys Glu Ser Gln Thr Val Gly Arg Lys Arg Arg His
 145                 150                 155                 160
 Arg Leu Cys Ser Thr Ile Ala Val Asn Leu
                 165                 170



      <210> 350
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 350
 Met Ala Pro Arg Ala Leu Pro Gly Ser Ala Val Leu Ala Ala Ala Val
   1               5                  10                  15    
 Phe Val Gly Gly Ala Val Ser Ser Pro Leu Val Ala Pro Asp Asn Gly
              20                  25                  30        
 Ser Ser Arg Thr Leu His Ser Arg Thr Glu Thr Thr Pro Ser Pro Ser
          35                  40                  45            
 Asn Asp Thr Gly Asn Gly His Pro Glu Tyr Ile Ala Tyr Ala Leu Val
      50                  55                  60                
 Pro Val Phe Phe Ile Met Gly Leu Phe Gly Val Leu Ile Cys His Leu
  65                  70                  75                  80
 Leu Lys Lys Lys Gly Tyr Arg Cys Thr Thr Glu Ala Glu Gln Asp Ile
                  85                  90                  95    
 Glu Glu Glu Lys Val Glu Lys Ile Glu Leu Asn Asp Ser Val Asn Glu
             100                 105                 110        
 Asn Ser Asp Thr Val Gly Gln Ile Val His Tyr Ile Met Lys Asn Glu
         115                 120                 125            
 Ala Asn Ala Asp Val Leu Lys Ala Met Val Ala Asp Asn Ser Leu Tyr
     130                 135                 140                
 Asp Pro Glu Ser Pro Val Thr Pro Ser Thr Pro Gly Ser Pro Pro Val
 145                 150                 155                 160
 Ser Pro Gly Pro Leu Ser Pro Gly Gly Thr Pro Gly Lys His Val Cys
                 165                 170                 175    
 Gly His His Leu His Thr Val Gly Gly Val Val Glu Arg Asp Val Cys
             180                 185                 190        
 His Arg Cys Arg His Lys Arg Trp His Phe Ile Lys Pro Thr Asn Lys
         195                 200                 205            
 Ser Arg Glu Ser Arg Pro Arg Arg Gln Gly Glu Val Thr Val Leu Ser
     210                 215                 220                
 Val Gly Arg Phe Arg Val Thr Lys Val Glu His Lys Ser Asn Gln Lys
 225                 230                 235                 240
 Glu Arg Arg Ser Leu Met Ser Val Ser Gly Ala Glu Thr Val Asn Gly
                 245                 250                 255    
 Glu Val Pro Ala Thr Pro Val Lys Arg Glu Arg Ser Gly Thr Glu
             260                 265                 270    



      <210> 351
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 351
 Met Arg Pro Glu His Lys Arg Lys Ile Leu Val Leu Gly Leu Pro Thr
   1               5                  10                  15    
 Ser Arg Ser Lys Leu Cys Phe Val Leu Phe Cys Phe Val Leu Phe Cys
              20                  25                  30        
 Phe Val Leu Phe Val Lys Leu Phe Pro Gly Leu Phe Leu Gln His Leu
          35                  40                  45            
 Phe Leu Ser Leu Thr Asp Ser Phe His Ala Lys Val Thr Gln Thr Pro
      50                  55                  60                
 Gly His Leu Val Lys Gly Lys Gly Gln Lys Thr Lys Met Asp Cys Thr
  65                  70                  75                  80
 Pro Glu Lys Gly His Thr Phe Val Tyr Trp Tyr Gln Gln Asn Gln Asn
                  85                  90                  95    
 Lys Glu Phe Met Leu Leu Ile Ser Phe Gln Asn Glu Gln Val Leu Gln
             100                 105                 110        
 Glu Thr Glu Met His Lys Lys Arg Phe Ser Ser Gln Cys Pro Lys Asn
         115                 120                 125            
 Pro Pro Cys Ser Leu Ala Ile Leu Ser Ser Glu Pro Gly Asp Thr Ala
     130                 135                 140                
 Leu Tyr Leu Cys Ala Thr Ser Pro Ser Thr Ala Leu Lys Cys Gln Phe
 145                 150                 155                 160
 Leu Leu Ala His Lys Leu Ala Thr Asp Pro Ala Gln Glu Ala Gly Asp
                 165                 170                 175    
 Val Leu Gly Trp Lys Gly Val Thr Glu Asn Asn Trp Ser Gln Leu Lys
             180                 185                 190        
 Pro Gln Trp Asn Leu Thr Gln Gly
         195                 200



      <210> 352
      <211> 48
      <212> PRT
      <213> Homo sapiens


      <400> 352
 Met Leu Pro Leu Met Thr Tyr Ile Ile Gln Tyr Ile Tyr Thr Tyr Ile
   1               5                  10                  15    
 Phe Phe Val Arg Val Leu Ala Ile Leu Phe Leu Arg Arg Val Leu Ser
              20                  25                  30        
 Gln Thr Leu Leu His Ala Val Tyr Gly Val Ser Cys Val Leu Ile Phe
          35                  40                  45            





      <210> 353
      <211> 101
      <212> PRT
      <213> Homo sapiens


      <400> 353
 Met Glu Ser Ser Val Pro Phe Glu Lys Ala Asn Leu Gln Leu Ala Phe
   1               5                  10                  15    
 Val Ile Leu Ala Ile Phe Cys Leu Phe Ala Lys Ser Leu Ile Val Pro
              20                  25                  30        
 Ser Val Val Cys Leu Pro Val Ile Ser Ala Pro Pro Glu Ser Leu Leu
          35                  40                  45            
 Glu Met Arg His Pro Asn Pro Thr Thr Ala Leu Pro Ser Gln Ile Leu
      50                  55                  60                
 Pro Pro His Glu Ala Pro Gln Gly Ser Thr Ser Ser Leu Lys Phe Gln
  65                  70                  75                  80
 Glu Ser Asn Ser Thr Thr Lys Tyr Thr Phe Ile Ile Arg Lys Arg Ile
                  85                  90                  95    
 Val Ser Phe Lys Trp
             100    



      <210> 354
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 354
 Met Leu Leu Met Lys Ser Ile Leu Leu Lys Val Val Cys Val Leu Cys
   1               5                  10                  15    
 Ile Tyr Leu Lys Phe Lys Leu Met Ala Leu Ile Tyr Val Pro Asp Lys
              20                  25                  30        
 Asn Asn Thr Asn Asn Asn Ile Leu Arg Tyr Asn His Asn Glu Ile Ser
          35                  40                  45            
 Ile Gly Ile Ser Val Gln Cys His Phe Ile Leu Ser Leu Cys Val Leu
      50                  55                  60                
 Cys Ile Val Leu Thr Asn Leu Pro Asn Arg
  65                  70                



      <210> 355
      <211> 618
      <212> PRT
      <213> Homo sapiens


      <400> 355
 Met Ala Pro Pro Leu Leu Leu Leu Leu Leu Ala Ser Gly Ala Ala Ala
   1               5                  10                  15    
 Cys Pro Leu Pro Cys Val Cys Gln Asn Leu Ser Glu Ser Leu Ser Thr
              20                  25                  30        
 Leu Cys Ala His Arg Gly Leu Leu Phe Val Pro Pro Asn Val Asp Arg
          35                  40                  45            
 Arg Thr Val Glu Leu Arg Leu Ala Asp Asn Phe Ile Gln Ala Leu Gly
      50                  55                  60                
 Pro Pro Asp Phe Arg Asn Met Thr Gly Leu Val Asp Leu Thr Leu Ser
  65                  70                  75                  80
 Arg Asn Ala Ile Thr Arg Ile Gly Ala Arg Ala Phe Gly Asp Leu Glu
                  85                  90                  95    
 Ser Leu Arg Ser Leu His Leu Asp Gly Asn Arg Leu Val Glu Leu Gly
             100                 105                 110        
 Thr Gly Ser Leu Arg Gly Pro Val Asn Leu Gln His Leu Ile Leu Ser
         115                 120                 125            
 Gly Asn Gln Leu Gly Arg Ile Ala Pro Gly Ala Phe Asp Asp Phe Leu
     130                 135                 140                
 Glu Ser Leu Glu Asp Leu Asp Leu Ser Tyr Asn Asn Leu Arg Gln Val
 145                 150                 155                 160
 Pro Trp Ala Gly Ile Gly Ala Met Pro Ala Leu His Thr Leu Asn Leu
                 165                 170                 175    
 Asp His Asn Leu Ile Asp Ala Leu Pro Pro Gly Ala Phe Ala Gln Leu
             180                 185                 190        
 Gly Gln Leu Ser Arg Leu Asp Leu Thr Ser Asn Arg Leu Ala Thr Leu
         195                 200                 205            
 Ala Pro Asp Pro Leu Phe Ser Pro Gly Thr Leu His Cys Asn Cys Glu
     210                 215                 220                
 Leu Leu Trp Leu Arg Arg Leu Ala Arg Pro Asp Asp Leu Glu Thr Cys
 225                 230                 235                 240
 Ala Ser Pro Pro Gly Leu Ala Gly Arg Tyr Phe Trp Ala Val Pro Glu
                 245                 250                 255    
 Gly Glu Phe Ser Cys Glu Pro Pro Leu Ile Ala Arg His Thr Gln Arg
             260                 265                 270        
 Leu Trp Val Leu Glu Gly Gln Arg Ala Thr Leu Arg Cys Arg Ala Leu
         275                 280                 285            
 Gly Asp Pro Ala Pro Thr Met His Trp Val Gly Pro Asp Asp Arg Leu
     290                 295                 300                
 Val Gly Asn Ser Ser Arg Ala Arg Ala Phe Pro Asn Gly Thr Leu Glu
 305                 310                 315                 320
 Ile Gly Val Thr Gly Ala Gly Asp Ala Gly Gly Tyr Thr Cys Ile Ala
                 325                 330                 335    
 Thr Asn Pro Ala Gly Glu Ala Thr Ala Arg Val Glu Leu Arg Val Leu
             340                 345                 350        
 Ala Leu Pro His Gly Gly Asn Ser Ser Ala Glu Gly Gly Arg Pro Gly
         355                 360                 365            
 Pro Ser Asp Ile Ala Ala Ser Ala Arg Thr Ala Ala Glu Gly Glu Gly
     370                 375                 380                
 Thr Leu Glu Ser Glu Pro Ala Val Gln Val Thr Glu Val Thr Ala Thr
 385                 390                 395                 400
 Ser Gly Leu Val Ser Trp Gly Pro Gly Arg Pro Ala Asp Pro Val Trp
                 405                 410                 415    
 Met Phe Gln Ile Gln Tyr Asn Ser Ser Glu Asp Glu Thr Leu Ile Tyr
             420                 425                 430        
 Arg Ile Val Pro Ala Ser Ser His His Phe Leu Leu Lys His Leu Val
         435                 440                 445            
 Pro Gly Ala Asp Tyr Asp Leu Cys Leu Leu Ala Leu Ser Pro Ala Ala
     450                 455                 460                
 Gly Pro Ser Asp Leu Thr Ala Thr Arg Leu Leu Gly Cys Ala His Phe
 465                 470                 475                 480
 Ser Thr Leu Pro Ala Ser Pro Leu Cys His Ala Leu Gln Ala His Val
                 485                 490                 495    
 Leu Gly Gly Thr Leu Thr Val Ala Val Gly Gly Val Leu Val Ala Ala
             500                 505                 510        
 Leu Leu Val Phe Thr Val Ala Leu Leu Val Arg Gly Arg Gly Ala Gly
         515                 520                 525            
 Asn Gly Arg Leu Pro Leu Lys Leu Ser His Val Gln Ser Gln Thr Asn
     530                 535                 540                
 Gly Gly Pro Ser Pro Thr Pro Lys Ala His Pro Pro Arg Ser Pro Pro
 545                 550                 555                 560
 Pro Arg Pro Gln Arg Ser Cys Ser Leu Asp Leu Gly Asp Ala Gly Cys
                 565                 570                 575    
 Tyr Gly Tyr Ala Arg Arg Leu Gly Gly Ala Trp Ala Arg Arg Ser His
             580                 585                 590        
 Ser Val His Gly Gly Leu Leu Gly Ala Gly Cys Arg Gly Val Gly Gly
         595                 600                 605            
 Ser Ala Glu Arg Leu Glu Glu Ser Val Val
     610                 615            



      <210> 356
      <211> 343
      <212> PRT
      <213> Homo sapiens


      <400> 356
 Met Val Pro Ala Ala Gly Arg Arg Pro Pro Arg Val Met Arg Leu Leu
   1               5                  10                  15    
 Gly Trp Trp Gln Val Leu Leu Trp Val Leu Gly Leu Pro Val Arg Gly
              20                  25                  30        
 Val Glu Val Ala Glu Glu Ser Gly Arg Leu Trp Ser Glu Glu Leu Leu
          35                  40                  45            
 His Asp Pro Met Gly Arg Asp Arg Ala Ala Glu Glu Ala Asn Ala Val
      50                  55                  60                
 Leu Gly Leu Asp Thr Gln Gly Asp His Met Val Met Leu Ser Val Ile
  65                  70                  75                  80
 Pro Gly Glu Ala Glu Asp Lys Val Ser Ser Glu Pro Ser Gly Val Thr
                  85                  90                  95    
 Cys Gly Ala Gly Gly Ala Glu Asp Ser Arg Cys Asn Val Arg Glu Ser
             100                 105                 110        
 Leu Phe Ser Leu Asp Gly Ala Gly Ala His Phe Pro Asp Arg Glu Glu
         115                 120                 125            
 Glu Tyr Tyr Thr Glu Pro Glu Val Ala Glu Ser Asp Ala Ala Pro Thr
     130                 135                 140                
 Glu Asp Ser Asn Asn Thr Glu Ser Leu Lys Ser Pro Lys Val Asn Cys
 145                 150                 155                 160
 Glu Glu Arg Asn Ile Thr Gly Leu Glu Asn Phe Thr Leu Lys Ile Leu
                 165                 170                 175    
 Asn Met Ser Gln Asp Leu Met Asp Phe Leu Asn Pro Asn Gly Ser Asp
             180                 185                 190        
 Cys Thr Leu Val Leu Phe Tyr Thr Pro Trp Cys Arg Phe Ser Ala Ser
         195                 200                 205            
 Leu Ala Pro His Phe Asn Ser Leu Pro Arg Ala Phe Pro Ala Leu His
     210                 215                 220                
 Phe Leu Ala Leu Asp Ala Ser Gln His Ser Ser Leu Ser Thr Arg Phe
 225                 230                 235                 240
 Gly Thr Val Ala Val Pro Asn Ile Leu Leu Phe Gln Gly Ala Lys Pro
                 245                 250                 255    
 Met Ala Arg Phe Asn His Thr Asp Arg Thr Leu Glu Thr Leu Lys Ile
             260                 265                 270        
 Phe Ile Phe Asn Gln Thr Gly Ile Glu Ala Lys Lys Asn Val Val Val
         275                 280                 285            
 Thr Gln Ala Asp Gln Ile Gly Pro Leu Pro Ser Thr Leu Ile Lys Ser
     290                 295                 300                
 Val Asp Trp Leu Leu Val Phe Ser Leu Phe Phe Leu Ile Ser Phe Ile
 305                 310                 315                 320
 Met Tyr Ala Thr Ile Arg Thr Glu Ser Ile Arg Trp Leu Ile Pro Gly
                 325                 330                 335    
 Gln Glu Gln Glu His Val Glu
             340            



      <210> 357
      <211> 956
      <212> PRT
      <213> Homo sapiens


      <400> 357
 Met Pro Gly Gly Ala Gly Ala Ala Arg Leu Cys Leu Leu Ala Phe Ala
   1               5                  10                  15    
 Leu Gln Pro Leu Arg Pro Arg Ala Ala Arg Glu Pro Gly Trp Thr Ser
              20                  25                  30        
 Lys Gly Ser Glu Glu Gly Ser Pro Lys Leu Gln His Glu Leu Ile Ile
          35                  40                  45            
 Pro Gln Trp Lys Thr Ser Glu Ser Pro Val Arg Glu Lys His Pro Leu
      50                  55                  60                
 Lys Ala Glu Leu Arg Val Met Ala Glu Gly Arg Glu Leu Ile Leu Asp
  65                  70                  75                  80
 Leu Glu Lys Asn Glu Gln Leu Phe Ala Pro Ser Tyr Thr Glu Thr His
                  85                  90                  95    
 Tyr Thr Ser Ser Gly Asn Pro Gln Thr Thr Thr Arg Lys Leu Glu Asp
             100                 105                 110        
 His Cys Phe Tyr His Gly Thr Val Arg Glu Thr Glu Leu Ser Ser Val
         115                 120                 125            
 Thr Leu Ser Thr Cys Arg Gly Ile Arg Gly Leu Ile Thr Val Ser Ser
     130                 135                 140                
 Asn Leu Ser Tyr Val Ile Glu Pro Leu Pro Asp Ser Lys Gly Gln His
 145                 150                 155                 160
 Leu Ile Tyr Arg Ser Glu His Leu Lys Pro Pro Pro Gly Asn Cys Gly
                 165                 170                 175    
 Phe Glu His Ser Lys Pro Thr Thr Arg Asp Trp Ala Leu Gln Phe Thr
             180                 185                 190        
 Gln Gln Thr Lys Lys Arg Pro Arg Arg Met Lys Arg Glu Asp Leu Asn
         195                 200                 205            
 Ser Met Lys Tyr Val Glu Leu Tyr Leu Val Ala Asp Tyr Leu Glu Phe
     210                 215                 220                
 Gln Lys Asn Arg Arg Asp Gln Asp Ala Thr Lys His Lys Leu Ile Glu
 225                 230                 235                 240
 Ile Ala Asn Tyr Val Asp Lys Phe Tyr Arg Ser Leu Asn Ile Arg Ile
                 245                 250                 255    
 Ala Leu Val Gly Leu Glu Val Trp Thr His Gly Asn Met Cys Glu Val
             260                 265                 270        
 Ser Glu Asn Pro Tyr Ser Thr Leu Trp Ser Phe Leu Ser Trp Arg Arg
         275                 280                 285            
 Lys Leu Leu Ala Gln Lys Tyr His Asp Asn Ala Gln Leu Ile Thr Gly
     290                 295                 300                
 Met Ser Phe His Gly Thr Thr Ile Gly Leu Ala Pro Leu Met Ala Met
 305                 310                 315                 320
 Cys Ser Val Tyr Gln Ser Gly Gly Val Asn Met Asp His Ser Glu Asn
                 325                 330                 335    
 Ala Ile Gly Val Ala Ala Thr Met Ala His Glu Met Gly His Asn Phe
             340                 345                 350        
 Gly Met Thr His Asp Ser Ala Asp Cys Cys Ser Ala Ser Ala Ala Asp
         355                 360                 365            
 Gly Gly Cys Ile Met Ala Ala Ala Thr Gly His Pro Phe Pro Lys Val
     370                 375                 380                
 Phe Asn Gly Cys Asn Arg Arg Glu Leu Asp Arg Tyr Leu Gln Ser Gly
 385                 390                 395                 400
 Gly Gly Met Cys Leu Ser Asn Met Pro Asp Thr Arg Met Leu Tyr Gly
                 405                 410                 415    
 Gly Arg Arg Cys Gly Asn Gly Tyr Leu Glu Asp Gly Glu Glu Cys Asp
             420                 425                 430        
 Cys Gly Glu Glu Glu Glu Cys Asn Asn Pro Cys Cys Asn Ala Ser Asn
         435                 440                 445            
 Cys Thr Leu Arg Pro Gly Ala Glu Cys Ala His Gly Ser Cys Cys His
     450                 455                 460                
 Gln Cys Lys Leu Leu Ala Pro Gly Thr Leu Cys Arg Glu Gln Ala Arg
 465                 470                 475                 480
 Gln Cys Asp Leu Pro Glu Phe Cys Thr Gly Lys Ser Pro His Cys Pro
                 485                 490                 495    
 Thr Asn Phe Tyr Gln Met Asp Gly Thr Pro Cys Glu Gly Gly Gln Ala
             500                 505                 510        
 Tyr Cys Tyr Asn Gly Met Cys Leu Thr Tyr Gln Glu Gln Cys Gln Gln
         515                 520                 525            
 Leu Trp Gly Pro Gly Ala Arg Pro Ala Pro Asp Leu Cys Phe Glu Lys
     530                 535                 540                
 Val Asn Val Ala Gly Asp Thr Phe Gly Asn Cys Gly Lys Asp Met Asn
 545                 550                 555                 560
 Gly Glu His Arg Lys Cys Asn Met Arg Asp Ala Lys Cys Gly Lys Ile
                 565                 570                 575    
 Gln Cys Gln Ser Ser Glu Ala Arg Pro Leu Glu Ser Asn Ala Val Pro
             580                 585                 590        
 Ile Asp Thr Thr Ile Ile Met Asn Gly Arg Gln Ile Gln Cys Arg Gly
         595                 600                 605            
 Thr His Val Tyr Arg Gly Pro Glu Glu Glu Gly Asp Met Leu Asp Pro
     610                 615                 620                
 Gly Leu Val Met Thr Gly Thr Lys Cys Gly Tyr Asn His Ile Cys Phe
 625                 630                 635                 640
 Glu Gly Gln Cys Arg Asn Thr Ser Phe Phe Glu Thr Glu Gly Cys Gly
                 645                 650                 655    
 Lys Lys Cys Asn Gly His Gly Val Cys Asn Asn Asn Gln Asn Cys His
             660                 665                 670        
 Cys Leu Pro Gly Trp Ala Pro Pro Phe Cys Asn Thr Pro Gly His Gly
         675                 680                 685            
 Gly Ser Ile Asp Ser Gly Pro Met Pro Pro Glu Ser Val Gly Pro Val
     690                 695                 700                
 Val Ala Gly Val Leu Val Ala Ile Leu Val Leu Ala Val Leu Met Leu
 705                 710                 715                 720
 Met Tyr Tyr Cys Cys Arg Gln Asn Asn Lys Leu Gly Gln Leu Lys Pro
                 725                 730                 735    
 Ser Ala Leu Pro Ser Lys Leu Arg Gln Gln Phe Ser Cys Pro Phe Arg
             740                 745                 750        
 Val Ser Gln Asn Ser Gly Thr Gly His Ala Asn Pro Thr Phe Lys Leu
         755                 760                 765            
 Gln Thr Pro Gln Gly Lys Arg Lys Val Ile Asn Thr Pro Glu Ile Leu
     770                 775                 780                
 Arg Lys Pro Ser Gln Pro Pro Pro Arg Pro Pro Pro Asp Tyr Leu Arg
 785                 790                 795                 800
 Gly Gly Ser Pro Pro Ala Pro Leu Pro Ala His Leu Ser Arg Ala Ala
                 805                 810                 815    
 Arg Asn Ser Pro Gly Pro Gly Ser Gln Ile Glu Arg Thr Glu Ser Ser
             820                 825                 830        
 Arg Arg Pro Pro Pro Ser Arg Pro Ile Pro Pro Ala Pro Asn Cys Ile
         835                 840                 845            
 Val Ser Gln Asp Phe Ser Arg Pro Arg Pro Pro Gln Lys Ala Leu Pro
     850                 855                 860                
 Ala Asn Pro Val Pro Gly Arg Arg Ser Leu Pro Arg Pro Gly Gly Ala
 865                 870                 875                 880
 Ser Pro Leu Arg Pro Pro Gly Ala Gly Pro Gln Gln Ser Arg Pro Leu
                 885                 890                 895    
 Ala Ala Leu Ala Pro Lys Val Ser Pro Arg Glu Ala Leu Lys Val Lys
             900                 905                 910        
 Ala Gly Thr Arg Gly Leu Gln Gly Gly Arg Cys Arg Val Glu Lys Thr
         915                 920                 925            
 Lys Gln Phe Met Leu Leu Val Val Trp Thr Glu Leu Pro Glu Gln Lys
     930                 935                 940                
 Pro Arg Ala Lys His Ser Cys Phe Leu Val Pro Ala
 945                 950                 955    



      <210> 358
      <211> 382
      <212> PRT
      <213> Homo sapiens


      <400> 358
 Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val
   1               5                  10                  15    
 Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser
              20                  25                  30        
 Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Gly Cys His
          35                  40                  45            
 Ala Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val Cys Thr
      50                  55                  60                
 Glu Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu
  65                  70                  75                  80
 Ala Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe His Leu
                  85                  90                  95    
 Ile Val Ser Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala Lys Pro Val
             100                 105                 110        
 Phe Glu Gly Asp Leu Leu Val Leu Arg Cys Gln Ala Trp Gln Asp Trp
         115                 120                 125            
 Pro Leu Thr Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro
     130                 135                 140                
 Pro Gly Pro Asn Arg Glu Phe Ser Ile Thr Val Val Gln Lys Ala Asp
 145                 150                 155                 160
 Ser Gly His Tyr His Cys Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly
                 165                 170                 175    
 Ile Pro Glu Thr Ala Ser Val Val Ala Ile Thr Val Gln Glu Leu Phe
             180                 185                 190        
 Pro Ala Pro Ile Leu Arg Ala Val Pro Ser Ala Glu Pro Gln Ala Gly
         195                 200                 205            
 Ser Pro Met Thr Leu Ser Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser
     210                 215                 220                
 Ala Ala Arg Leu Leu Phe Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln
 225                 230                 235                 240
 Ser Arg Gly Leu Ser Ser Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp
                 245                 250                 255    
 His Ser Gly Ser Tyr Trp Cys Glu Ala Ala Thr Glu Asp Asn Gln Val
             260                 265                 270        
 Trp Lys Gln Ser Pro Gln Leu Glu Ile Arg Val Gln Gly Ala Ser Ser
         275                 280                 285            
 Ser Ala Ala Pro Pro Thr Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala
     290                 295                 300                
 Pro Gly Thr Ala Pro Glu Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro
 305                 310                 315                 320
 Thr Pro Ser Ser Glu Asp Pro Gly Phe Ser Ser Pro Leu Gly Met Pro
                 325                 330                 335    
 Asp Pro His Leu Tyr His Gln Met Gly Leu Leu Leu Lys His Met Gln
             340                 345                 350        
 Asp Val Arg Val Leu Leu Gly His Leu Leu Met Glu Leu Arg Glu Leu
         355                 360                 365            
 Ser Gly His Arg Lys Pro Gly Thr Thr Lys Ala Thr Ala Glu
     370                 375                 380        



      <210> 359
      <211> 376
      <212> PRT
      <213> Homo sapiens


      <400> 359
 Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly Asp Leu Asn Thr Val
   1               5                  10                  15    
 Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp Ala Leu Tyr Leu Ser
              20                  25                  30        
 Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu Ala Ala Ser Phe Glu
          35                  40                  45            
 Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu Glu Ser Ser Cys His
      50                  55                  60                
 Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala Gly Phe Gln Val Lys
  65                  70                  75                  80
 Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile Val Ser Tyr Asp Trp
                  85                  90                  95    
 Leu Ile Leu Gln Gly Pro Ala Lys Pro Val Phe Glu Gly Asp Leu Leu
             100                 105                 110        
 Val Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro Leu Thr Gln Val Thr
         115                 120                 125            
 Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro Gly Pro Asn Arg Glu
     130                 135                 140                
 Phe Ser Ile Thr Val Val Gln Lys Ala Asp Ser Gly His Tyr His Cys
 145                 150                 155                 160
 Ser Gly Ile Phe Gln Ser Pro Gly Pro Gly Ile Pro Glu Thr Ala Ser
                 165                 170                 175    
 Val Val Ala Ile Thr Val Gln Glu Leu Phe Pro Ala Pro Ile Leu Arg
             180                 185                 190        
 Ala Val Pro Ser Ala Glu Pro Gln Ala Gly Ser Pro Met Thr Leu Ser
         195                 200                 205            
 Cys Gln Thr Lys Leu Pro Leu Gln Arg Ser Ala Ala Arg Leu Leu Phe
     210                 215                 220                
 Ser Phe Tyr Lys Asp Gly Arg Ile Val Gln Ser Arg Gly Leu Ser Ser
 225                 230                 235                 240
 Glu Phe Gln Ile Pro Thr Ala Ser Glu Asp His Ser Gly Ser Tyr Trp
                 245                 250                 255    
 Cys Glu Ala Ala Thr Glu Asp Asn Gln Val Trp Lys Gln Ser Pro Gln
             260                 265                 270        
 Leu Glu Ile Arg Val Gln Gly Ala Ser Ser Ser Ala Ala Pro Pro Thr
         275                 280                 285            
 Leu Asn Pro Ala Pro Gln Lys Ser Ala Ala Pro Gly Thr Ala Pro Glu
     290                 295                 300                
 Glu Ala Pro Gly Pro Leu Pro Pro Pro Pro Thr Pro Ser Ser Glu Asp
 305                 310                 315                 320
 Pro Gly Phe Ser Ser Pro Leu Gly Met Pro Asp Pro His Leu Tyr His
                 325                 330                 335    
 Gln Met Gly Leu Leu Leu Lys His Met Gln Asp Val Arg Val Leu Leu
             340                 345                 350        
 Gly His Leu Leu Met Glu Leu Arg Glu Leu Ser Gly His Arg Lys Pro
         355                 360                 365            
 Gly Thr Thr Lys Ala Thr Ala Glu
     370                 375    



      <210> 360
      <211> 55
      <212> PRT
      <213> Homo sapiens


      <400> 360
 Met Tyr Val Asn Tyr Ser Thr Glu Gly Pro Ala Ala Leu Leu Asp Gln
   1               5                  10                  15    
 Ala Lys Leu Ser Leu Leu Val Trp Val Leu Cys Phe Val Leu Leu Phe
              20                  25                  30        
 Val Cys Phe Cys Gly Leu Ser Tyr Val Val Ile Ala Gln Val Pro Val
          35                  40                  45            
 Gly Leu Leu Cys Ile Thr Glu
      50                  55



      <210> 361
      <211> 291
      <212> PRT
      <213> Homo sapiens


      <400> 361
 Met Gly Val Ala Ala Arg Pro Pro Ala Leu Arg His Trp Phe Ser His
   1               5                  10                  15    
 Ser Ile Pro Leu Ala Ile Phe Ala Leu Leu Leu Leu Tyr Leu Ser Val
              20                  25                  30        
 Arg Ser Leu Gly Ala Arg Ser Gly Cys Gly Pro Arg Ala Gln Pro Cys
          35                  40                  45            
 Val Pro Gly Glu Thr Ala Pro Phe Gln Val Arg Gln Glu Ser Gly Thr
      50                  55                  60                
 Leu Glu Ala Pro Glu Arg Lys Gln Pro Pro Cys Leu Gly Pro Arg Gly
  65                  70                  75                  80
 Met Leu Gly Arg Met Met Arg Arg Phe His Ala Ser Leu Lys Pro Glu
                  85                  90                  95    
 Gly Asp Val Gly Leu Ser Pro Tyr Leu Ala Gly Trp Arg Ala Leu Val
             100                 105                 110        
 Glu Phe Leu Thr Pro Leu Gly Ser Val Phe Ala Phe Ala Thr Arg Glu
         115                 120                 125            
 Ala Phe Thr Lys Val Thr Asp Leu Glu Ala Arg Val His Gly Pro Asp
     130                 135                 140                
 Ala Glu His Tyr Trp Ser Leu Ala Ala Met Ala Ala Trp Glu Arg Arg
 145                 150                 155                 160
 Ala Gly Leu Leu Glu Gln Pro Gly Ala Ala Pro Arg Asp Pro Thr Arg
                 165                 170                 175    
 Ser Ser Gly Ser Arg Thr Leu Leu Leu Leu His Arg Ala Leu Arg Trp
             180                 185                 190        
 Ser Gln Leu Cys Leu His Arg Val Ala Thr Gly Ala Leu Gly Gly Pro
         195                 200                 205            
 Glu Ala Gly Val Gln Cys Ser Asp Ala Tyr Arg Ala Ala Leu Gly Pro
     210                 215                 220                
 His His Pro Trp Leu Val Arg Gln Thr Ala Arg Leu Ala Phe Leu Ala
 225                 230                 235                 240
 Phe Pro Gly Arg Arg Arg Leu Leu Glu Leu Ala Cys Pro Gly Ala Thr
                 245                 250                 255    
 Glu Ala Glu Ala Arg Ala Ala Leu Leu Arg Ala Ala Gly Thr Leu Glu
             260                 265                 270        
 Asp Val Tyr Asn Arg Thr Gln Ser Leu Leu Ala Glu Arg Gly Leu Leu
         275                 280                 285            
 Gln Leu Ala
     290    



      <210> 362
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 362
 Met Ala Leu Pro Ser Arg Ile Leu Leu Trp Lys Leu Val Leu Leu Gln
   1               5                  10                  15    
 Ser Ser Ala Val Leu Leu His Ser Gly Ser Ser Val Pro Ala Ala Ala
              20                  25                  30        
 Gly Ser Ser Val Val Ser Glu Ser Ala Val Ser Trp Glu Ala Gly Ala
          35                  40                  45            
 Arg Ala Val Leu Arg Cys Gln Ser Pro Arg Met Val Trp Thr Gln Asp
      50                  55                  60                
 Arg Leu His Asp Arg Gln Arg Val Leu His Trp Asp Leu Arg Gly Pro
  65                  70                  75                  80
 Gly Gly Gly Pro Ala Arg Arg Leu Leu Asp Leu Tyr Ser Ala Gly Glu
                  85                  90                  95    
 Gln Arg Val Tyr Glu Ala Arg Asp Arg Gly Arg Leu Glu Leu Ser Ala
             100                 105                 110        
 Ser Ala Phe Asp Asp Gly Asn Phe Ser Leu Leu Ile Arg Ala Val Glu
         115                 120                 125            
 Glu Thr Asp Ala Gly Leu Tyr Thr Cys Asn Leu His His His Tyr Cys
     130                 135                 140                
 His Leu Tyr Glu Ser Leu Ala Val Arg Leu Glu Val Thr Asp Gly Pro
 145                 150                 155                 160
 Pro Ala Thr Pro Ala Tyr Trp Asp Gly Glu Lys Glu Val Leu Ala Val
                 165                 170                 175    
 Ala Arg Gly Ala Pro Ala Leu Leu Thr Cys Val Asn Arg Gly His Val
             180                 185                 190        
 Trp Thr Asp Arg His Val Glu Glu Ala Gln Gln Val Val His Trp Asp
         195                 200                 205            
 Arg Gln Pro Pro Gly Val Pro His Asp Arg Ala Asp Arg Leu Leu Asp
     210                 215                 220                
 Leu Tyr Ala Ser Gly Glu Arg Arg Ala Tyr Gly Pro Leu Phe Leu Arg
 225                 230                 235                 240
 Asp Arg Val Ala Val Gly Ala Asp Ala Phe Glu Arg Gly Asp Phe Ser
                 245                 250                 255    
 Leu Arg Ile Glu Pro Leu Glu Val Ala Asp Glu Gly Thr Tyr Ser Cys
             260                 265                 270        
 His Leu His His His Tyr Cys Gly Leu His Glu Arg Arg Val Phe His
         275                 280                 285            
 Leu Thr Val Ala Glu Pro His Ala Glu Pro Pro Pro Arg Gly Ser Pro
     290                 295                 300                
 Gly Asn Gly Ser Ser His Ser Gly Ala Pro Gly Pro Asp Pro Thr Leu
 305                 310                 315                 320
 Ala Arg Gly His Asn Val Ile Asn Val Ile Val Pro Glu Ser Arg Ala
                 325                 330                 335    
 His Phe Phe Gln Gln Leu Gly Tyr Val Leu Ala Thr Leu Leu Leu Phe
             340                 345                 350        
 Ile Leu Leu Leu Val Thr Val Leu Leu Ala Ala Arg Arg Arg Arg Gly
         355                 360                 365            
 Gly Tyr Glu Tyr Ser Asp Gln Lys Ser Gly Lys Ser Lys Gly Lys Asp
     370                 375                 380                
 Val Asn Leu Ala Glu Phe Ala Val Ala Ala Gly Asp Gln Met Leu Tyr
 385                 390                 395                 400
 Arg Ser Glu Asp Ile Gln Leu Asp Tyr Lys Asn Asn Ile Leu Lys Glu
                 405                 410                 415    
 Arg Ala Glu Leu Ala His Ser Pro Leu Pro Ala Lys Tyr Ile Asp Leu
             420                 425                 430        
 Asp Lys Gly Phe Arg Lys Glu Asn Cys Lys
         435                 440        



      <210> 363
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 363
 Met Ala Leu Tyr Glu Leu Phe Ser His Pro Val Glu Arg Ser Tyr Arg
   1               5                  10                  15    
 Ala Gly Leu Cys Ser Lys Ala Ala Leu Phe Leu Leu Leu Ala Ala Ala
              20                  25                  30        
 Leu Thr Tyr Ile Pro Pro Leu Leu Val Ala Phe Arg Ser His Gly Phe
          35                  40                  45            
 Trp Leu Lys Arg Ser Ser Tyr Glu Glu Gln Pro Thr Val Arg Phe Gln
      50                  55                  60                
 His Gln Val Leu Leu Val Ala Leu Leu Gly Pro Glu Ser Asp Gly Phe
  65                  70                  75                  80
 Leu Ala Trp Ser Thr Phe Pro Ala Phe Asn Arg Leu Gln Gly Asp Arg
                  85                  90                  95    
 Leu Arg Val Pro Leu Val Ser Thr Arg Glu Glu Asp Arg Asn Gln Asp
             100                 105                 110        
 Gly Lys Thr Asp Met Leu His Phe Lys Leu Glu Leu Pro Leu Gln Ser
         115                 120                 125            
 Thr Glu His Val Leu Gly Val Gln Leu Ile Leu Thr Phe Ser Tyr Arg
     130                 135                 140                
 Leu His Arg Met Ala Thr Leu Val Met Gln Ser Met Ala Phe Leu Gln
 145                 150                 155                 160
 Ser Ser Phe Pro Val Pro Gly Ser Gln Leu Tyr Val Asn Gly Asp Leu
                 165                 170                 175    
 Arg Leu Gln Gln Lys Gln Pro Leu Ser Cys Gly Gly Leu Asp Ala Arg
             180                 185                 190        
 Tyr Asn Ile Ser Val Ile Asn Gly Thr Ser Pro Phe Ala Tyr Asp Tyr
         195                 200                 205            
 Asp Leu Thr His Ile Val Ala Ala Tyr Gln Glu Arg Asn Val Thr Thr
     210                 215                 220                
 Val Leu Asn Asp Pro Asn Pro Ile Trp Leu Val Gly Arg Ala Ala Asp
 225                 230                 235                 240
 Ala Pro Phe Val Ile Asn Ala Ile Ile Arg Tyr Pro Val Glu Val Ile
                 245                 250                 255    
 Ser Tyr Gln Pro Gly Phe Trp Glu Met Val Lys Phe Ala Trp Val Gln
             260                 265                 270        
 Tyr Val Ser Ile Leu Leu Ile Phe Leu Trp Val Phe Glu Arg Ile Lys
         275                 280                 285            
 Ile Phe Val Phe Gln Asn Gln Val Val Thr Thr Ile Pro Val Thr Val
     290                 295                 300                
 Thr Pro Arg Gly Asp Leu Cys Lys Glu His Leu Ser
 305                 310                 315    



      <210> 364
      <211> 274
      <212> PRT
      <213> Homo sapiens


      <400> 364
 Met Leu Thr Pro Met Val Ala Gly Gly Val Val Phe Pro Gly Leu Phe
   1               5                  10                  15    
 Leu Leu Ser Lys Asn Thr Leu Gln Arg Leu Pro Gln Leu Arg Trp Glu
              20                  25                  30        
 Glu Ala Asp Ala Val Ile Val Ser Ala Arg Leu Val Ser Ser Val Gln
          35                  40                  45            
 Ala Ile Met Ala Ser Thr Ala Gly Tyr Ile Val Ser Thr Ser Cys Lys
      50                  55                  60                
 His Ile Ile Asp Asp Gln His Trp Leu Ser Ser Ala Tyr Thr Gln Phe
  65                  70                  75                  80
 Ala Val Pro Tyr Phe Ile Tyr Asp Ile Tyr Ala Met Phe Leu Cys His
                  85                  90                  95    
 Trp His Lys His Gln Val Lys Gly His Gly Gly Asp Asp Gly Ala Ala
             100                 105                 110        
 Arg Ala Pro Gly Ser Thr Trp Ala Ile Ala Arg Gly Tyr Leu His Lys
         115                 120                 125            
 Glu Phe Leu Met Val Leu His His Ala Ala Met Val Leu Val Cys Phe
     130                 135                 140                
 Pro Leu Ser Val Val Trp Arg Gln Gly Lys Gly Asp Phe Phe Leu Gly
 145                 150                 155                 160
 Cys Met Leu Met Ala Glu Val Ser Thr Pro Phe Val Cys Leu Gly Lys
                 165                 170                 175    
 Ile Leu Ile Gln Tyr Lys Gln Gln His Thr Leu Leu His Lys Val Asn
             180                 185                 190        
 Gly Ala Leu Met Leu Leu Ser Phe Leu Cys Cys Arg Val Leu Leu Phe
         195                 200                 205            
 Pro Tyr Leu Tyr Trp Ala Tyr Gly Arg His Ala Gly Leu Pro Leu Leu
     210                 215                 220                
 Ala Val Pro Leu Ala Ile Pro Ala His Val Asn Leu Gly Ala Ala Leu
 225                 230                 235                 240
 Leu Leu Ala Pro Gln Leu Tyr Trp Phe Phe Leu Ile Cys Arg Gly Ala
                 245                 250                 255    
 Cys Arg Leu Phe Trp Pro Arg Ser Arg Pro Pro Pro Ala Cys Gln Ala
             260                 265                 270        
 Gln Asp
        



      <210> 365
      <211> 496
      <212> PRT
      <213> Homo sapiens


      <400> 365
 Met Asp Cys Tyr Arg Thr Ser Leu Ser Ser Ser Trp Ile Tyr Pro Thr
   1               5                  10                  15    
 Val Ile Leu Cys Leu Phe Gly Phe Phe Ser Met Met Arg Pro Ser Glu
              20                  25                  30        
 Pro Phe Leu Ile Pro Tyr Leu Ser Gly Pro Asp Lys Asn Leu Thr Ser
          35                  40                  45            
 Ala Glu Ile Thr Asn Glu Ile Phe Pro Val Trp Thr Tyr Ser Tyr Leu
      50                  55                  60                
 Val Leu Leu Leu Pro Val Phe Val Leu Thr Asp Tyr Val Arg Tyr Lys
  65                  70                  75                  80
 Pro Val Ile Ile Leu Gln Gly Ile Ser Phe Ile Ile Thr Trp Leu Leu
                  85                  90                  95    
 Leu Leu Phe Gly Gln Gly Val Lys Thr Met Gln Val Val Glu Phe Phe
             100                 105                 110        
 Tyr Gly Met Val Thr Ala Ala Glu Val Ala Tyr Tyr Ala Tyr Ile Tyr
         115                 120                 125            
 Ser Val Val Ser Pro Glu His Tyr Gln Arg Val Ser Gly Tyr Cys Arg
     130                 135                 140                
 Ser Val Thr Leu Ala Ala Tyr Thr Ala Gly Ser Val Leu Ala Gln Leu
 145                 150                 155                 160
 Leu Val Ser Leu Ala Asn Met Ser Tyr Phe Tyr Leu Asn Val Ile Ser
                 165                 170                 175    
 Leu Ala Ser Val Ser Val Ala Phe Leu Phe Ser Leu Phe Leu Pro Met
             180                 185                 190        
 Pro Lys Lys Ser Met Phe Phe His Ala Lys Pro Ser Arg Glu Ile Lys
         195                 200                 205            
 Lys Ser Ser Ser Val Asn Pro Val Leu Glu Glu Thr His Glu Gly Glu
     210                 215                 220                
 Ala Pro Gly Cys Glu Glu Gln Lys Pro Thr Ser Glu Ile Leu Ser Thr
 225                 230                 235                 240
 Ser Gly Lys Leu Asn Lys Gly Gln Leu Asn Ser Leu Lys Pro Ser Asn
                 245                 250                 255    
 Val Thr Val Asp Val Phe Val Gln Trp Phe Gln Asp Leu Lys Glu Cys
             260                 265                 270        
 Tyr Ser Ser Lys Arg Leu Phe Tyr Trp Ser Leu Trp Trp Ala Phe Ala
         275                 280                 285            
 Thr Ala Gly Phe Asn Gln Val Leu Asn Tyr Val Gln Ile Leu Trp Asp
     290                 295                 300                
 Tyr Lys Ala Pro Ser Gln Asp Ser Ser Ile Tyr Asn Gly Ala Val Glu
 305                 310                 315                 320
 Ala Ile Ala Thr Phe Gly Gly Ala Val Ala Ala Phe Ala Val Gly Tyr
                 325                 330                 335    
 Val Lys Val Asn Trp Asp Leu Leu Gly Glu Leu Ala Leu Val Val Phe
             340                 345                 350        
 Ser Val Val Asn Ala Gly Ser Leu Phe Leu Met His Tyr Thr Ala Asn
         355                 360                 365            
 Ile Trp Ala Cys Tyr Ala Gly Tyr Leu Ile Phe Lys Ser Ser Tyr Met
     370                 375                 380                
 Leu Leu Ile Thr Ile Ala Val Phe Gln Ile Ala Val Asn Leu Asn Val
 385                 390                 395                 400
 Glu Arg Tyr Ala Leu Val Phe Gly Ile Asn Thr Phe Ile Ala Leu Val
                 405                 410                 415    
 Ile Gln Thr Ile Met Thr Val Ile Val Val Asp Gln Arg Gly Leu Asn
             420                 425                 430        
 Leu Pro Val Ser Ile Gln Phe Leu Val Tyr Gly Ser Tyr Phe Ala Val
         435                 440                 445            
 Ile Ala Gly Ile Phe Leu Met Arg Ser Met Tyr Ile Thr Tyr Ser Thr
     450                 455                 460                
 Lys Ser Gln Lys Asp Val Gln Ser Pro Ala Pro Ser Glu Asn Pro Asp
 465                 470                 475                 480
 Val Ser His Pro Glu Glu Glu Ser Asn Ile Ile Met Ser Thr Lys Leu
                 485                 490                 495    





      <210> 366
      <211> 144
      <212> PRT
      <213> Homo sapiens


      <400> 366
 Met Ile Ser Ile Thr Glu Trp Gln Lys Ile Gly Val Gly Ile Thr Gly
   1               5                  10                  15    
 Phe Gly Ile Phe Phe Ile Leu Phe Gly Thr Leu Leu Tyr Phe Asp Ser
              20                  25                  30        
 Val Leu Leu Ala Phe Gly Asn Leu Leu Phe Leu Thr Gly Leu Ser Leu
          35                  40                  45            
 Ile Ile Gly Leu Arg Lys Thr Phe Trp Phe Phe Phe Gln Arg His Lys
      50                  55                  60                
 Leu Lys Gly Thr Ser Phe Leu Leu Gly Gly Val Val Ile Val Leu Leu
  65                  70                  75                  80
 Arg Trp Pro Leu Leu Gly Met Phe Leu Glu Thr Tyr Gly Phe Phe Ser
                  85                  90                  95    
 Leu Phe Lys Gly Phe Phe Pro Val Ala Phe Gly Phe Leu Gly Asn Val
             100                 105                 110        
 Cys Asn Ile Pro Phe Leu Gly Ala Val Ser Ser Met Met Pro Ala Ala
         115                 120                 125            
 Leu Arg Ser Ser Leu Gly Ser Glu Ala Glu Tyr Thr Glu Gly Ser Trp
     130                 135                 140                





      <210> 367
      <211> 495
      <212> PRT
      <213> Homo sapiens


      <400> 367
 Met Arg Leu Thr Arg Cys Gln Ala Ala Leu Ala Ala Ala Ile Thr Leu
   1               5                  10                  15    
 Asn Leu Leu Val Leu Phe Tyr Val Ser Trp Leu Gln His Gln Pro Arg
              20                  25                  30        
 Asn Ser Arg Ala Arg Gly Pro Arg Arg Ala Ser Ala Ala Gly Pro Arg
          35                  40                  45            
 Val Thr Val Leu Val Arg Glu Phe Glu Ala Phe Asp Asn Ala Val Pro
      50                  55                  60                
 Glu Leu Val Asp Ser Phe Leu Gln Gln Asp Pro Ala Gln Pro Val Val
  65                  70                  75                  80
 Val Ala Ala Asp Thr Leu Pro Tyr Pro Pro Leu Ala Leu Pro Arg Ile
                  85                  90                  95    
 Pro Asn Val Arg Leu Ala Leu Leu Gln Pro Ala Leu Asp Arg Pro Ala
             100                 105                 110        
 Ala Ala Ser Arg Pro Glu Thr Tyr Val Ala Thr Glu Phe Val Ala Leu
         115                 120                 125            
 Val Pro Asp Gly Ala Arg Ala Glu Ala Pro Gly Leu Leu Glu Arg Met
     130                 135                 140                
 Val Glu Ala Leu Arg Ala Gly Ser Ala Arg Leu Val Ala Ala Pro Val
 145                 150                 155                 160
 Ala Thr Ala Asn Pro Ala Arg Cys Leu Ala Leu Asn Val Ser Leu Arg
                 165                 170                 175    
 Glu Trp Thr Ala Arg Tyr Gly Ala Ala Pro Ala Ala Pro Arg Cys Asp
             180                 185                 190        
 Ala Leu Asp Gly Asp Ala Val Val Leu Leu Arg Ala Arg Asp Leu Phe
         195                 200                 205            
 Asn Leu Ser Ala Pro Leu Ala Arg Pro Val Gly Thr Ser Leu Phe Leu
     210                 215                 220                
 Gln Thr Ala Leu Arg Gly Trp Ala Val Gln Leu Leu Asp Leu Thr Phe
 225                 230                 235                 240
 Ala Ala Ala Arg Gln Pro Pro Leu Ala Thr Ala His Ala Arg Trp Lys
                 245                 250                 255    
 Ala Glu Arg Glu Gly Arg Ala Arg Arg Ala Ala Leu Leu Arg Ala Leu
             260                 265                 270        
 Gly Ile Arg Leu Val Ser Trp Glu Gly Gly Arg Leu Glu Trp Phe Gly
         275                 280                 285            
 Cys Asn Lys Glu Thr Thr Arg Cys Phe Gly Thr Val Val Gly Asp Thr
     290                 295                 300                
 Pro Ala Tyr Leu Tyr Glu Glu Arg Trp Thr Pro Pro Cys Cys Leu Arg
 305                 310                 315                 320
 Ala Leu Arg Glu Thr Ala Arg Tyr Val Val Gly Val Leu Glu Ala Ala
                 325                 330                 335    
 Gly Val Arg Tyr Trp Leu Glu Gly Gly Ser Leu Leu Gly Ala Ala Arg
             340                 345                 350        
 His Gly Asp Ile Ile Pro Trp Asp Tyr Asp Val Asp Leu Gly Ile Tyr
         355                 360                 365            
 Leu Glu Asp Val Gly Asn Cys Glu Gln Leu Arg Gly Ala Glu Ala Gly
     370                 375                 380                
 Ser Val Val Asp Glu Arg Gly Phe Val Trp Glu Lys Ala Val Glu Gly
 385                 390                 395                 400
 Asp Phe Phe Arg Val Gln Tyr Ser Glu Ser Asn His Leu His Val Asp
                 405                 410                 415    
 Leu Trp Pro Phe Tyr Pro Arg Asn Gly Val Met Thr Lys Asp Thr Trp
             420                 425                 430        
 Leu Asp His Arg Gln Asp Val Glu Phe Pro Glu His Phe Leu Gln Pro
         435                 440                 445            
 Leu Val Pro Leu Pro Phe Ala Gly Phe Val Ala Gln Ala Pro Asn Asn
     450                 455                 460                
 Tyr Arg Arg Phe Leu Glu Leu Lys Phe Gly Pro Gly Val Ile Glu Asn
 465                 470                 475                 480
 Pro Gln Tyr Pro Asn Pro Ala Leu Leu Ser Leu Thr Gly Ser Gly
                 485                 490                 495



      <210> 368
      <211> 379
      <212> PRT
      <213> Homo sapiens


      <400> 368
 Met Leu Pro Ile Thr Asp Arg Leu Leu His Leu Leu Gly Leu Glu Lys
   1               5                  10                  15    
 Thr Ala Phe Arg Ile Tyr Ala Val Ser Thr Leu Leu Leu Phe Leu Leu
              20                  25                  30        
 Phe Phe Leu Phe Arg Leu Leu Leu Arg Phe Leu Arg Leu Cys Arg Ser
          35                  40                  45            
 Phe Tyr Ile Thr Cys Arg Arg Leu Arg Cys Phe Pro Gln Pro Pro Arg
      50                  55                  60                
 Arg Asn Trp Leu Leu Gly His Leu Gly Met Tyr Leu Pro Asn Glu Ala
  65                  70                  75                  80
 Gly Leu Gln Asp Glu Lys Lys Val Leu Asp Asn Met His His Val Leu
                  85                  90                  95    
 Leu Val Trp Met Gly Pro Val Leu Pro Leu Leu Val Leu Val His Pro
             100                 105                 110        
 Asp Tyr Ile Lys Pro Leu Leu Gly Ala Ser Ala Ala Ile Ala Pro Lys
         115                 120                 125            
 Asp Asp Leu Phe Tyr Gly Phe Leu Lys Pro Trp Leu Gly Asp Gly Leu
     130                 135                 140                
 Leu Leu Ser Lys Gly Asp Lys Trp Ser Arg His Arg Arg Leu Leu Thr
 145                 150                 155                 160
 Pro Ala Phe His Phe Asp Ile Leu Lys Pro Tyr Met Lys Ile Phe Asn
                 165                 170                 175    
 Gln Ser Ala Asp Ile Met His Ala Lys Trp Arg His Leu Ala Glu Gly
             180                 185                 190        
 Ser Ala Val Ser Leu Asp Met Phe Glu His Ile Ser Leu Met Thr Leu
         195                 200                 205            
 Asp Ser Leu Gln Lys Cys Val Phe Ser Tyr Asn Ser Asn Cys Gln Glu
     210                 215                 220                
 Lys Met Ser Asp Tyr Ile Ser Ala Ile Ile Glu Leu Ser Ala Leu Ser
 225                 230                 235                 240
 Val Arg Arg Gln Tyr Arg Leu His His Tyr Leu Asp Phe Ile Tyr Tyr
                 245                 250                 255    
 Arg Ser Ala Asp Gly Arg Arg Phe Arg Gln Ala Cys Asp Met Val His
             260                 265                 270        
 His Phe Thr Thr Glu Val Ile Gln Glu Arg Arg Arg Ala Leu Arg Gln
         275                 280                 285            
 Gln Gly Ala Glu Ala Trp Leu Lys Ala Lys Gln Gly Lys Thr Leu Asp
     290                 295                 300                
 Phe Ile Asp Val Leu Leu Leu Ala Arg Asp Glu Asp Gly Lys Glu Leu
 305                 310                 315                 320
 Ser Asp Glu Asp Ile Arg Ala Glu Ala Asp Thr Phe Met Phe Glu Gly
                 325                 330                 335    
 His Asp Thr Thr Ser Ser Gly Ile Ser Trp Met Leu Phe Asn Leu Ala
             340                 345                 350        
 Lys Tyr Pro Glu Tyr Gln Glu Lys Cys Arg Glu Glu Ile Gln Glu Val
         355                 360                 365            
 Met Lys Gly Arg Glu Leu Glu Glu Leu Glu Trp
     370                 375                



      <210> 369
      <211> 932
      <212> PRT
      <213> Homo sapiens


      <400> 369
 Met Val Leu Pro Pro Ser Leu Met Val Ala Gly Val Tyr Cys Leu Val
   1               5                  10                  15    
 Val Ala Val Ile Phe Ala Thr Ile Lys Thr Val Asn Tyr Arg Leu His
              20                  25                  30        
 Ala Met Phe Asp Gln Gly Glu Ile Val Glu Lys Arg Ser Ser Thr Met
          35                  40                  45            
 Gly Glu Leu Glu Glu Glu Pro Ala Gln Gly Asp Ser Asn Pro Pro Arg
      50                  55                  60                
 Asp Pro Gly Val Glu Met Thr Val Phe Arg Lys Val Ser Ser Thr Pro
  65                  70                  75                  80
 Pro Val Arg Cys Ser Ser Gln His Ser Val Phe Gly Phe Asn Gln Val
                  85                  90                  95    
 Ser Glu Leu Leu Pro Arg Met Glu Asp Ser Gly Pro Leu Arg Asp Ile
             100                 105                 110        
 Lys Glu Leu Val Arg Glu Gln Gly Ser Asn Asn Val Ile Val Thr Ser
         115                 120                 125            
 Ala Asp Arg Glu Met Leu Lys Leu Ser Ser Gln Glu Lys Leu Ile Gly
     130                 135                 140                
 Asp Leu Pro Gln Thr Pro Pro Gly Ala Val Pro Asp Pro Ser Leu Ala
 145                 150                 155                 160
 Ser Thr Asp Ser Ser Glu Pro Ser Pro Leu Ala Gly Asp Gly Ala Pro
                 165                 170                 175    
 Trp Ser Gly Ser Ser Met Ala Asp Thr Pro Met Ser Pro Leu Leu Lys
             180                 185                 190        
 Gly Ser Leu Ser Gln Glu Leu Ser Lys Ser Phe Leu Thr Leu Thr Arg
         195                 200                 205            
 Pro Asp Arg Ala Leu Val Arg Thr Ser Ser Arg Arg Glu Gln Arg Arg
     210                 215                 220                
 Gly Ala Gly Gly Tyr Gln Pro Leu Asp Arg Arg Gly Ser Gly Glu Pro
 225                 230                 235                 240
 Thr Pro Gln Lys Ala Gly Ser Ser Asp Ser Cys Phe Ser Gly Thr Asp
                 245                 250                 255    
 Arg Glu Thr Leu Ser Ser Phe Lys Ser Glu Lys Thr Asn Ser Thr His
             260                 265                 270        
 Leu Asp Ser Pro Pro Gly Gly Pro Ala Pro Glu Gly Ser Asp Thr Asp
         275                 280                 285            
 Pro Pro Ser Glu Ala Glu Leu Pro Ala Ser Pro Asp Ala Gly Val Pro
     290                 295                 300                
 Ser Asp Asp Thr Leu Arg Ser Phe Asp Thr Val Ile Gly Ala Gly Thr
 305                 310                 315                 320
 Pro Pro Gly Leu Ala Glu Pro Leu Leu Val Val Arg Pro Lys Asp Leu
                 325                 330                 335    
 Ala Leu Leu Arg Pro Ser Lys Arg Gln Pro Pro Leu Arg Arg His Ser
             340                 345                 350        
 Pro Pro Gly Arg Ala Pro Arg Arg Pro Leu Leu Glu Gly Gly Gly Phe
         355                 360                 365            
 Phe Glu Asp Glu Asp Thr Ser Glu Gly Ser Glu Leu Ser Pro Ala Ser
     370                 375                 380                
 Ser Leu Arg Ser Gln Arg Arg Tyr Ser Thr Asp Ser Ser Ser Ser Thr
 385                 390                 395                 400
 Ser Cys Tyr Ser Pro Glu Ser Ser Arg Gly Ala Ala Gly Gly Pro Arg
                 405                 410                 415    
 Lys Arg Arg Ala Pro His Gly Ala Glu Glu Gly Thr Ala Val Pro Pro
             420                 425                 430        
 Lys Arg Pro Tyr Gly Thr Gln Arg Thr Pro Ser Thr Ala Ser Ala Lys
         435                 440                 445            
 Thr His Ala Arg Val Leu Ser Met Asp Gly Ala Gly Gly Asp Val Leu
     450                 455                 460                
 Arg Pro Pro Leu Ala Gly Cys Lys Ala Glu Leu Glu Ala Gln Val Gly
 465                 470                 475                 480
 Val Glu Gln Ala Ala Ser Glu Pro Val Val Leu Pro Ala Glu Ala Arg
                 485                 490                 495    
 Arg Gly Pro Ala Ala Asn Gln Pro Gly Trp Arg Gly Glu Leu Gln Glu
             500                 505                 510        
 Glu Gly Ala Val Gly Gly Ala Ala Glu Glu Thr Gly Arg Arg Asp Arg
         515                 520                 525            
 Ser Ser Ser Val Arg Arg Thr Gln Ala Ile Arg Arg Arg His Asn Ala
     530                 535                 540                
 Gly Ser Asn Pro Thr Pro Pro Ala Ser Val Met Gly Ser Pro Pro Ser
 545                 550                 555                 560
 Ser Leu Gln Glu Ala Gln Arg Gly Arg Ala Ala Ser His Ser Arg Ala
                 565                 570                 575    
 Leu Thr Leu Pro Ser Ala Leu His Phe Ala Ser Ser Leu Leu Leu Thr
             580                 585                 590        
 Arg Ala Gly Ala Asn Val His Glu Ala Cys Thr Phe Asp Asp Thr Ser
         595                 600                 605            
 Glu Gly Ala Val His Tyr Phe Tyr Asp Glu Ser Gly Val Arg Arg Ser
     610                 615                 620                
 Tyr Thr Phe Gly Leu Ala Gly Gly Gly Tyr Glu Asn Pro Val Gly Gln
 625                 630                 635                 640
 Gln Gly Glu Gln Thr Ala Asn Gly Ala Trp Asp Arg His Ser His Ser
                 645                 650                 655    
 Ser Ser Phe His Ser Ala Asp Val Pro Glu Ala Thr Gly Gly Leu Asn
             660                 665                 670        
 Leu Leu Gln Pro Arg Pro Val Val Leu Gln Gly Met Gln Val Arg Arg
         675                 680                 685            
 Val Pro Leu Glu Ile Pro Glu Glu Gln Thr Leu Met Glu Glu Ala Pro
     690                 695                 700                
 Pro Arg Ala Gln His Ser Tyr Lys Tyr Trp Leu Leu Pro Gly Arg Trp
 705                 710                 715                 720
 Thr Ser Val Arg Tyr Glu Arg Leu Ala Leu Leu Ala Leu Leu Asp Arg
                 725                 730                 735    
 Thr Arg Gly Val Leu Glu Asn Ile Phe Gly Val Gly Leu Ser Ser Leu
             740                 745                 750        
 Val Ala Phe Leu Gly Tyr Leu Leu Leu Leu Lys Gly Phe Phe Thr Asp
         755                 760                 765            
 Ile Trp Val Phe Gln Phe Cys Leu Val Ile Ala Ser Cys Gln Tyr Ser
     770                 775                 780                
 Leu Leu Lys Ser Val Gln Pro Asp Ala Ala Ser Pro Met His Gly His
 785                 790                 795                 800
 Asn Trp Val Ile Ala Tyr Ser Arg Pro Val Tyr Phe Cys Ile Cys Cys
                 805                 810                 815    
 Leu Leu Ile Trp Leu Leu Asp Ala Leu Gly Ser Ala Gln Pro Phe Pro
             820                 825                 830        
 Pro Val Ser Leu Tyr Gly Leu Thr Leu Phe Ser Ala Ser Phe Phe Phe
         835                 840                 845            
 Cys Ala Arg Asp Val Ala Thr Val Phe Thr Leu Cys Phe Pro Phe Val
     850                 855                 860                
 Phe Leu Leu Gly Leu Leu Pro Gln Val Asn Thr Cys Pro Arg Pro Arg
 865                 870                 875                 880
 Ser Pro Pro Glu Ala Leu Pro Cys Leu His Ile Cys Phe Ala Leu Thr
                 885                 890                 895    
 Gln Phe Gly Asn Ser Asn Cys Pro Ala Glu Val His Ser Pro Asp Pro
             900                 905                 910        
 Phe Pro Thr Leu Val Arg Val Ala Gly Phe Ser Lys Pro Leu Ser Gly
         915                 920                 925            
 Ile Ser Leu Cys
     930        



      <210> 370
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 370
 Met Phe Thr Leu Leu Val Leu Leu Ser Gln Leu Pro Thr Val Thr Leu
   1               5                  10                  15    
 Gly Phe Pro His Cys Ala Arg Gly Pro Lys Ala Ser Lys His Ala Gly
              20                  25                  30        
 Glu Glu Val Phe Thr Ser Lys Glu Glu Ala Asn Phe Phe Ile His Arg
          35                  40                  45            
 Arg Leu Leu Tyr Asn Arg Phe Asp Leu Glu Leu Phe Thr Pro Gly Asn
      50                  55                  60                
 Leu Glu Arg Glu Cys Asn Glu Glu Leu Cys Asn Tyr Glu Glu Ala Arg
  65                  70                  75                  80
 Glu Ile Phe Val Asp Glu Asp Lys Thr Ile Ala Phe Trp Gln Glu Tyr
                  85                  90                  95    
 Ser Ala Lys Gly Pro Thr Thr Lys Ser Asp Gly Asn Arg Glu Lys Ile
             100                 105                 110        
 Asp Val Met Gly Leu Leu Thr Gly Leu Ile Ala Ala Gly Val Phe Leu
         115                 120                 125            
 Val Ile Phe Gly Leu Leu Gly Tyr Tyr Leu Cys Ile Thr Lys Cys Asn
     130                 135                 140                
 Arg Leu Gln His Pro Cys Ser Ser Ala Val Tyr Glu Arg Gly Arg His
 145                 150                 155                 160
 Thr Pro Ser Ile Ile Phe Arg Arg Pro Glu Glu Ala Ala Leu Ser Pro
                 165                 170                 175    
 Leu Pro Pro Ser Val Glu Asp Ala Gly Leu Pro Ser Tyr Glu Gln Ala
             180                 185                 190        
 Val Ala Leu Thr Arg Lys His Ser Val Ser Pro Pro Pro Pro Tyr Pro
         195                 200                 205            
 Gly His Thr Lys Gly Phe Arg Val Phe Lys Lys Ser Met Ser Leu Pro
     210                 215                 220                
 Ser His
 225    



      <210> 371
      <211> 399
      <212> PRT
      <213> Homo sapiens


      <400> 371
 Met Pro Leu Tyr Glu Gly Leu Gly Ser Gly Gly Glu Lys Thr Ala Val
   1               5                  10                  15    
 Val Ile Asp Leu Gly Glu Ala Phe Thr Lys Cys Gly Phe Ala Gly Glu
              20                  25                  30        
 Thr Gly Pro Arg Cys Ile Ile Pro Ser Val Ile Glu Glu Leu Tyr Ser
          35                  40                  45            
 Tyr Leu Lys Glu Phe Ile His Ile Leu Tyr Phe Arg His Leu Leu Val
      50                  55                  60                
 Asn Pro Arg Asp Arg Arg Val Val Ile Ile Glu Ser Val Leu Cys Pro
  65                  70                  75                  80
 Ser His Phe Arg Glu Thr Leu Thr Arg Val Leu Phe Lys Tyr Phe Glu
                  85                  90                  95    
 Val Pro Ser Val Leu Leu Ala Pro Ser His Leu Met Ala Leu Leu Thr
             100                 105                 110        
 Leu Gly Ile Asn Ser Ala Met Val Leu Asp Cys Gly Tyr Arg Glu Ser
         115                 120                 125            
 Leu Val Leu Pro Ile Tyr Glu Gly Ile Pro Val Leu Asn Cys Trp Gly
     130                 135                 140                
 Ala Leu Pro Leu Gly Gly Lys Ala Leu His Lys Glu Leu Glu Thr Gln
 145                 150                 155                 160
 Leu Leu Glu Gln Cys Thr Val Asp Thr Ser Val Ala Lys Glu Gln Ser
                 165                 170                 175    
 Leu Pro Ser Val Met Gly Ser Val Pro Glu Gly Val Leu Glu Asp Ile
             180                 185                 190        
 Lys Ala Arg Thr Cys Phe Val Ser Asp Leu Lys Arg Gly Leu Lys Ile
         195                 200                 205            
 Gln Ala Ala Lys Phe Asn Ile Asp Gly Asn Asn Glu Arg Pro Ser Pro
     210                 215                 220                
 Pro Pro Asn Val Asp Tyr Pro Leu Asp Gly Glu Lys Ile Leu His Ile
 225                 230                 235                 240
 Leu Gly Ser Ile Arg Asp Ser Val Val Glu Ile Leu Phe Glu Gln Asp
                 245                 250                 255    
 Asn Glu Glu Gln Ser Val Ala Thr Leu Ile Leu Asp Ser Leu Ile Gln
             260                 265                 270        
 Cys Pro Ile Asp Thr Arg Lys Gln Leu Ala Glu Asn Leu Val Val Ile
         275                 280                 285            
 Gly Gly Thr Ser Met Leu Pro Gly Phe Leu His Arg Leu Leu Ala Glu
     290                 295                 300                
 Ile Arg Tyr Leu Val Glu Lys Pro Lys Tyr Lys Lys Ala Leu Gly Thr
 305                 310                 315                 320
 Lys Thr Phe Arg Ile His Thr Pro Pro Ala Lys Ala Asn Cys Val Ala
                 325                 330                 335    
 Trp Leu Gly Gly Ala Ile Phe Gly Ala Leu Gln Asp Ile Leu Gly Ser
             340                 345                 350        
 Arg Ser Val Ser Lys Glu Tyr Tyr Asn Gln Thr Gly Arg Ile Pro Asp
         355                 360                 365            
 Trp Cys Ser Leu Asn Asn Pro Pro Leu Glu Met Met Phe Asp Val Gly
     370                 375                 380                
 Lys Thr Gln Pro Pro Leu Met Lys Arg Ala Phe Ser Thr Glu Lys
 385                 390                 395                



      <210> 372
      <211> 544
      <212> PRT
      <213> Homo sapiens


      <400> 372
 Met Glu Lys Leu Gln Glu His Leu Ile Lys Ala Lys Ala Phe Thr Ile
   1               5                  10                  15    
 Lys Lys Thr Leu Glu Ile Tyr Val Pro Ile Lys Gln Phe Phe Tyr Asn
              20                  25                  30        
 Leu Ile His Pro Glu Tyr Ser Ala Val Thr Asp Val Tyr Val Leu Met
          35                  40                  45            
 Phe Leu Ala Asp Thr Val Asp Phe Ile Ile Ile Val Phe Gly Phe Trp
      50                  55                  60                
 Ala Phe Gly Lys His Ser Ala Ala Ala Asp Ile Thr Ser Ser Leu Ser
  65                  70                  75                  80
 Glu Asp Gln Val Pro Gly Pro Phe Leu Val Met Val Leu Ile Gln Phe
                  85                  90                  95    
 Gly Thr Met Val Val Asp Arg Ala Leu Tyr Leu Arg Lys Thr Val Leu
             100                 105                 110        
 Gly Lys Val Ile Phe Gln Val Ile Leu Val Phe Gly Ile His Phe Trp
         115                 120                 125            
 Met Phe Phe Ile Leu Pro Gly Val Thr Glu Arg Lys Phe Ser Gln Asn
     130                 135                 140                
 Leu Val Ala Gln Leu Trp Tyr Phe Val Lys Cys Val Tyr Phe Gly Leu
 145                 150                 155                 160
 Ser Ala Tyr Gln Ile Arg Cys Gly Tyr Pro Thr Arg Val Leu Gly Asn
                 165                 170                 175    
 Phe Leu Thr Lys Ser Tyr Asn Tyr Val Asn Leu Phe Leu Phe Gln Gly
             180                 185                 190        
 Phe Arg Leu Val Pro Phe Leu Thr Glu Leu Arg Ala Val Met Asp Trp
         195                 200                 205            
 Val Trp Thr Asp Thr Thr Leu Ser Leu Ser Ser Trp Ile Cys Val Glu
     210                 215                 220                
 Asp Ile Tyr Ala His Ile Phe Ile Leu Lys Cys Trp Arg Glu Ser Glu
 225                 230                 235                 240
 Lys Pro Ile Phe Thr Met Ser Ala Gln Gln Ser Gln Leu Lys Val Met
                 245                 250                 255    
 Asp Gln Gln Ser Phe Asn Lys Phe Ile Gln Ala Phe Ser Arg Asp Thr
             260                 265                 270        
 Gly Ala Met Gln Phe Leu Glu Asn Tyr Glu Lys Glu Asp Ile Thr Val
         275                 280                 285            
 Ala Glu Leu Glu Gly Asn Ser Asn Ser Leu Trp Thr Ile Ser Pro Pro
     290                 295                 300                
 Ser Lys Gln Lys Met Ile His Glu Leu Leu Asp Pro Asn Ser Ser Phe
 305                 310                 315                 320
 Ser Val Val Phe Ser Trp Ser Ile Gln Arg Asn Leu Ser Leu Gly Ala
                 325                 330                 335    
 Lys Ser Glu Ile Ala Thr Asp Lys Leu Ser Phe Pro Leu Lys Asn Ile
             340                 345                 350        
 Thr Arg Lys Asn Ile Ala Lys Met Ile Ala Gly Asn Ser Thr Glu Ser
         355                 360                 365            
 Ser Lys Thr Pro Val Thr Ile Glu Lys Ile Tyr Pro Tyr Tyr Val Lys
     370                 375                 380                
 Ala Pro Ser Asp Ser Asn Ser Lys Pro Ile Lys Gln Leu Leu Ser Glu
 385                 390                 395                 400
 Asn Asn Phe Met Asp Ile Thr Ile Ile Leu Ser Arg Asp Asn Thr Thr
                 405                 410                 415    
 Lys Tyr Asn Ser Glu Trp Trp Val Leu Asn Leu Thr Gly Asn Arg Ile
             420                 425                 430        
 Tyr Asn Pro Asn Ser Gln Ala Leu Glu Leu Val Val Phe Asn Asp Lys
         435                 440                 445            
 Val Ser Pro Pro Ser Leu Gly Phe Leu Ala Gly Tyr Gly Ile Met Gly
     450                 455                 460                
 Leu Tyr Ala Ser Val Val Leu Val Ile Gly Lys Phe Val Arg Glu Phe
 465                 470                 475                 480
 Phe Ser Gly Ile Ser His Ser Ile Met Phe Glu Glu Leu Pro Asn Val
                 485                 490                 495    
 Asp Arg Ile Leu Lys Leu Cys Thr Asp Ile Phe Leu Val Arg Glu Thr
             500                 505                 510        
 Gly Glu Leu Glu Leu Glu Glu Asp Leu Tyr Ala Lys Leu Ile Phe Leu
         515                 520                 525            
 Tyr Arg Ser Pro Glu Thr Met Ile Lys Trp Thr Arg Glu Lys Thr Asn
     530                 535                 540                





      <210> 373
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 373
 Met Glu Thr Ser Ala Ser Ser Ser Gln Pro Gln Asp Asn Ser Gln Val
   1               5                  10                  15    
 His Arg Glu Thr Glu Asp Val Asp Tyr Gly Glu Thr Asp Phe His Lys
              20                  25                  30        
 Gln Asp Gly Lys Ala Gly Leu Phe Ser Gln Glu Gln Tyr Glu Arg Asn
          35                  40                  45            
 Lys Ser Ser Ser Ser Ser Phe Ser Ser Ser Ser Ser Ser Ser Ser Ser
      50                  55                  60                
 Ser Ser Ser Ser Ser Ser Glu Ser Asn Asp Glu Asp Gln Gln Pro Arg
  65                  70                  75                  80
 Ala Thr Gly Lys His Arg Arg Ser Leu Gly Ala Gly Tyr Pro His Gly
                  85                  90                  95    
 Asn Gly Ser Pro Gly Pro Gly His Gly Glu Pro Asp Val Leu Lys Asp
             100                 105                 110        
 Glu Leu Gln Leu Tyr Gly Asp Ala Pro Gly Glu Val Val Pro Ser Gly
         115                 120                 125            
 Glu Ser Gly Leu Arg Arg Arg Gly Ser Asp Pro Ala Ser Gly Glu Val
     130                 135                 140                
 Glu Ala Ser Gln Leu Arg Arg Leu Asn Ile Lys Lys Asp Asp Glu Phe
 145                 150                 155                 160
 Phe His Phe Val Leu Leu Cys Phe Ala Ile Gly Ala Leu Leu Val Cys
                 165                 170                 175    
 Tyr His Tyr Tyr Ala Asp Trp Phe Met Ser Leu Gly Val Gly Leu Leu
             180                 185                 190        
 Thr Phe Ala Ser Leu Glu Thr Val Gly Ile Tyr Phe Gly Leu Val Tyr
         195                 200                 205            
 Arg Ile His Ser Val Leu Gln Gly Phe Ile Pro Leu Phe Gln Lys Phe
     210                 215                 220                
 Arg Leu Thr Gly Phe Arg Lys Thr Asp
 225                 230            



      <210> 374
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 374
 Met Thr Thr Ala Thr Pro Leu Gly Asp Thr Thr Phe Phe Ser Leu Asn
   1               5                  10                  15    
 Met Thr Thr Arg Gly Glu Asp Phe Leu Tyr Lys Ser Ser Gly Ala Ile
              20                  25                  30        
 Val Ala Ala Val Val Val Val Val Ile Ile Ile Phe Thr Val Val Leu
          35                  40                  45            
 Ile Leu Leu Lys Met Tyr Asn Arg Lys Met Arg Thr Arg Arg Glu Leu
      50                  55                  60                
 Glu Pro Lys Gly Pro Lys Pro Thr Ala Pro Ser Ala Val Gly Pro Asn
  65                  70                  75                  80
 Ser Asn Gly Ser Gln His Pro Ala Thr Val Thr Phe Ser Pro Val Asp
                  85                  90                  95    
 Val His Val Glu Thr Arg
             100        



      <210> 375
      <211> 568
      <212> PRT
      <213> Homo sapiens


      <400> 375
 Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys
   1               5                  10                  15    
 Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Glu Ile Gln His
              20                  25                  30        
 Ala Glu Glu Phe Leu Ile Lys Pro Glu Ser Lys Val Ala Lys Leu Val
          35                  40                  45            
 Thr Ser Gln Trp Pro Leu Leu Leu Lys Asn Phe Asp Lys Leu Asn Val
      50                  55                  60                
 Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn Pro Leu Lys
  65                  70                  75                  80
 Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn Leu Asp Lys
                  85                  90                  95    
 Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile Arg Arg Ile
             100                 105                 110        
 Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp Pro Lys Val
         115                 120                 125            
 Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg Leu Val Lys
     130                 135                 140                
 Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val Arg Leu His
 145                 150                 155                 160
 Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu Glu Thr Leu
                 165                 170                 175    
 Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala Val Lys Arg
             180                 185                 190        
 Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile Glu Tyr Asp
         195                 200                 205            
 Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu Ala Gly Thr
     210                 215                 220                
 Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu Gly Val Gly
 225                 230                 235                 240
 Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val Met Ser Glu
                 245                 250                 255    
 Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala Gln Trp Leu
             260                 265                 270        
 Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val Val Tyr Pro
         275                 280                 285            
 Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met Lys Asp Ser
     290                 295                 300                
 Ala Val Ser Ser Gly Leu Gly Val Tyr Ile Trp Lys Glu Arg Thr Pro
 305                 310                 315                 320
 Lys Met Arg Leu Ala Leu Phe Ile Ala Phe Leu Gly Phe Cys Gly Gly
                 325                 330                 335    
 Gln Gln Leu Gly Pro Leu His Leu Val Pro Ser Leu Gln Val Asn Ala
             340                 345                 350        
 Ile Cys Tyr Gly Ala Lys Ile Met Leu Pro Gly Val Leu Arg Tyr Glu
         355                 360                 365            
 Asp Gly Ile Glu Val Asn Gln Glu Ile Val Val Ile Thr Thr Lys Gly
     370                 375                 380                
 Glu Ala Ile Cys Met Ala Ile Ala Leu Met Thr Thr Ala Val Ile Ser
 385                 390                 395                 400
 Thr Cys Asp His Gly Ile Val Ala Lys Ile Lys Arg Val Ile Met Glu
                 405                 410                 415    
 Arg Asp Thr Tyr Pro Arg Lys Trp Gly Leu Gly Pro Lys Ala Ser Gln
             420                 425                 430        
 Lys Lys Leu Met Ile Lys Gln Gly Leu Leu Asp Lys His Gly Lys Pro
         435                 440                 445            
 Thr Asp Ser Thr Pro Ala Thr Trp Lys Gln Glu Tyr Val Asp Tyr Ser
     450                 455                 460                
 Glu Ser Ala Lys Lys Glu Val Val Ala Glu Val Val Lys Ala Pro Gln
 465                 470                 475                 480
 Val Val Ala Glu Ala Ala Lys Thr Ala Lys Val Ser Gly Met Leu Ser
                 485                 490                 495    
 Ser Val Trp Lys Arg Lys Arg Glu Ser Glu Ser Glu Ser Asp Glu Thr
             500                 505                 510        
 Pro Pro Ala Ala Pro Gln Leu Ile Lys Lys Glu Lys Lys Lys Ser Lys
         515                 520                 525            
 Lys Asp Lys Lys Ala Lys Ala Gly Leu Glu Ser Gly Ala Glu Pro Gly
     530                 535                 540                
 Asp Gly Asp Ser Asp Thr Thr Lys Lys Lys Lys Lys Lys Lys Lys Ala
 545                 550                 555                 560
 Lys Glu Val Glu Leu Val Ser Glu
                 565            



      <210> 376
      <211> 495
      <212> PRT
      <213> Homo sapiens


      <400> 376
 Met Ala Asp Ala Glu Val Ile Ile Leu Pro Lys Lys His Lys Lys Lys
   1               5                  10                  15    
 Lys Glu Arg Lys Ser Leu Pro Glu Glu Asp Val Ala Asn Phe Asp Lys
              20                  25                  30        
 Leu Asn Val Arg Thr Thr His Tyr Thr Pro Leu Ala Cys Gly Ser Asn
          35                  40                  45            
 Pro Leu Lys Arg Glu Ile Gly Asp Tyr Ile Arg Thr Gly Phe Ile Asn
      50                  55                  60                
 Leu Asp Lys Pro Ser Asn Pro Ser Ser His Glu Val Val Ala Trp Ile
  65                  70                  75                  80
 Arg Arg Ile Leu Arg Val Glu Lys Thr Gly His Ser Gly Thr Leu Asp
                  85                  90                  95    
 Pro Lys Val Thr Gly Cys Leu Ile Val Cys Ile Glu Arg Ala Thr Arg
             100                 105                 110        
 Leu Val Lys Ser Gln Gln Ser Ala Gly Lys Glu Tyr Val Gly Ile Val
         115                 120                 125            
 Arg Leu His Asn Ala Ile Glu Gly Gly Thr Gln Leu Ser Arg Ala Leu
     130                 135                 140                
 Glu Thr Leu Thr Gly Ala Leu Phe Gln Arg Pro Pro Leu Ile Ala Ala
 145                 150                 155                 160
 Val Lys Arg Gln Leu Arg Val Arg Thr Ile Tyr Glu Ser Lys Met Ile
                 165                 170                 175    
 Glu Tyr Asp Pro Glu Arg Arg Leu Gly Ile Phe Trp Val Ser Cys Glu
             180                 185                 190        
 Ala Gly Thr Tyr Ile Arg Thr Leu Cys Val His Leu Gly Leu Leu Leu
         195                 200                 205            
 Gly Val Gly Gly Gln Met Gln Glu Leu Arg Arg Val Arg Ser Gly Val
     210                 215                 220                
 Met Ser Glu Lys Asp His Met Val Thr Met His Asp Val Leu Asp Ala
 225                 230                 235                 240
 Gln Trp Leu Tyr Asp Asn His Lys Asp Glu Ser Tyr Leu Arg Arg Val
                 245                 250                 255    
 Val Tyr Pro Leu Glu Lys Leu Leu Thr Ser His Lys Arg Leu Val Met
             260                 265                 270        
 Lys Asp Ser Ala Val Asn Ala Ile Cys Tyr Gly Ala Lys Ile Met Leu
         275                 280                 285            
 Pro Gly Val Leu Arg Tyr Glu Asp Gly Ile Glu Val Asn Gln Glu Ile
     290                 295                 300                
 Val Val Ile Thr Thr Lys Gly Glu Ala Ile Cys Met Ala Ile Ala Leu
 305                 310                 315                 320
 Met Thr Thr Ala Val Ile Ser Thr Cys Asp His Gly Ile Val Ala Lys
                 325                 330                 335    
 Ile Lys Arg Val Ile Met Glu Arg Asp Thr Tyr Pro Arg Lys Trp Gly
             340                 345                 350        
 Leu Gly Pro Lys Ala Ser Gln Lys Lys Leu Met Ile Lys Gln Gly Leu
         355                 360                 365            
 Leu Asp Lys His Gly Lys Pro Thr Asp Ser Thr Pro Ala Thr Trp Lys
     370                 375                 380                
 Gln Glu Tyr Val Asp Tyr Ser Glu Ser Ala Lys Lys Glu Val Val Ala
 385                 390                 395                 400
 Glu Val Val Lys Ala Pro Gln Val Val Ala Glu Ala Ala Lys Thr Ala
                 405                 410                 415    
 Lys Val Ser Gly Met Leu Ser Ser Val Trp Lys Arg Lys Arg Glu Ser
             420                 425                 430        
 Glu Ser Glu Ser Asp Glu Thr Pro Pro Ala Ala Pro Gln Leu Ile Lys
         435                 440                 445            
 Lys Glu Lys Lys Lys Ser Lys Lys Asp Lys Lys Ala Lys Ala Gly Leu
     450                 455                 460                
 Glu Ser Gly Ala Glu Pro Gly Asp Gly Asp Ser Asp Thr Thr Lys Lys
 465                 470                 475                 480
 Lys Lys Lys Lys Lys Lys Ala Lys Glu Val Glu Leu Val Ser Glu
                 485                 490                 495



      <210> 377
      <211> 283
      <212> PRT
      <213> Homo sapiens


      <400> 377
 Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser
   1               5                  10                  15    
 Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu
              20                  25                  30        
 Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr
          35                  40                  45            
 Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His
      50                  55                  60                
 Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu
  65                  70                  75                  80
 Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu
                  85                  90                  95    
 Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln
             100                 105                 110        
 His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu
         115                 120                 125            
 Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu
     130                 135                 140                
 Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu
 145                 150                 155                 160
 Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Val Asp Ile Tyr Asn Ser
                 165                 170                 175    
 Asp Pro Leu Ile Cys Arg Ala Gly Leu Lys Val Cys Phe Gly Ile Gln
             180                 185                 190        
 Leu Leu Asn Ala Val Ser Arg Val Glu Arg Ala Leu Pro Lys Leu Thr
         195                 200                 205            
 Val Pro Phe Leu Leu Leu Gln Gly Ser Ala Asp Arg Leu Cys Asp Ser
     210                 215                 220                
 Lys Gly Ala Tyr Leu Leu Met Glu Leu Ala Lys Ser Gln Asp Lys Thr
 225                 230                 235                 240
 Leu Lys Ile Tyr Glu Gly Ala Tyr His Val Leu His Lys Glu Leu Pro
                 245                 250                 255    
 Glu Val Thr Asn Ser Val Phe His Glu Ile Asn Met Trp Val Ser Gln
             260                 265                 270        
 Arg Thr Ala Thr Ala Gly Thr Ala Ser Pro Pro
         275                 280            



      <210> 378
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 378
 Met Glu Thr Gly Pro Glu Asp Pro Ser Ser Met Pro Glu Glu Ser Ser
   1               5                  10                  15    
 Pro Arg Arg Thr Pro Gln Ser Ile Pro Tyr Gln Asp Leu Pro His Leu
              20                  25                  30        
 Val Asn Ala Asp Gly Gln Tyr Leu Phe Cys Arg Tyr Trp Lys Pro Thr
          35                  40                  45            
 Gly Thr Pro Lys Ala Leu Ile Phe Val Ser His Gly Ala Gly Glu His
      50                  55                  60                
 Ser Gly Arg Tyr Glu Glu Leu Ala Arg Met Leu Met Gly Leu Asp Leu
  65                  70                  75                  80
 Leu Val Phe Ala His Asp His Val Gly His Gly Gln Ser Glu Gly Glu
                  85                  90                  95    
 Arg Met Val Val Ser Asp Phe His Val Phe Val Arg Asp Val Leu Gln
             100                 105                 110        
 His Val Asp Ser Met Gln Lys Asp Tyr Pro Gly Leu Pro Val Phe Leu
         115                 120                 125            
 Leu Gly His Ser Met Gly Gly Ala Ile Ala Ile Leu Thr Ala Ala Glu
     130                 135                 140                
 Arg Pro Gly His Phe Ala Gly Met Val Leu Ile Ser Pro Leu Val Leu
 145                 150                 155                 160
 Ala Asn Pro Glu Ser Ala Thr Thr Phe Lys Asp Tyr Ser Arg Ile Leu
                 165                 170                 175    
 Lys His Leu Met Glu Lys Ala Ser Arg Met Leu Lys Phe Trp Ile Pro
             180                 185                 190        
 Arg Pro Phe Trp Val Leu Ala Ala Lys Val Leu Asn Leu Val Leu Pro
         195                 200                 205            
 Asn Leu Ser Leu Gly Pro Ile Asp Ser Ser Val Leu Ser Arg Asn Lys
     210                 215                 220                
 Thr Glu Val Asp Ile Tyr Asn Ser Asp Pro Leu Ile Cys Arg Ala Gly
 225                 230                 235                 240
 Leu Lys Val Cys Phe Gly Ile Gln Leu Leu Asn Ala Val Ser Arg Val
                 245                 250                 255    
 Glu Arg Ala Leu Pro Lys Leu Thr Val Pro Phe Leu Leu Leu Gln Gly
             260                 265                 270        
 Ser Ala Asp Arg Leu Cys Asp Ser Lys Gly Ala Tyr Leu Leu Met Glu
         275                 280                 285            
 Leu Ala Lys Ser Gln Asp Lys Thr Leu Lys Ile Tyr Glu Gly Ala Tyr
     290                 295                 300                
 His Val Leu His Lys Glu Leu Pro Glu Val Thr Asn Ser Val Phe His
 305                 310                 315                 320
 Glu Ile Asn Met Trp Val Ser Gln Arg Thr Ala Thr Ala Gly Thr Ala
                 325                 330                 335    
 Ser Pro Pro
            



      <210> 379
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 379
 Met Asp Cys Ser Gly Ala His Val Gln Val Thr Cys Ala Lys Leu Ile
   1               5                  10                  15    
 Ser Arg Thr Gly His Leu Met Lys Leu Leu Ser Gly Gln Gln Glu Val
              20                  25                  30        
 Lys Ala Ser Lys Ile Glu Trp Asp Thr Asp Gln Trp Lys Ile Glu Asn
          35                  40                  45            
 Tyr Ile Asn Glu Ser Thr Glu Ala Gln Ser Glu Gln Lys Glu Lys Ser
      50                  55                  60                
 Leu Glu Leu Lys Lys Glu Val Pro Gly Tyr Gly Tyr Thr Asp Lys Leu
  65                  70                  75                  80
 Ile Leu Ala Leu Ile Val Thr Gly Ile Leu Thr Ile Leu Ile Ile Leu
                  85                  90                  95    
 Phe Cys Leu Ile Val Ile Cys Cys His Arg Arg Ser Leu Gln Glu Asp
             100                 105                 110        
 Glu Glu Gly Phe Ser Arg Gly Ile Phe Arg Phe Leu Pro Arg Arg Gly
         115                 120                 125            
 Cys Ser Ser Arg Arg Glu Ser Gln Asp Gly Leu Ser Ser Phe Gly Gln
     130                 135                 140                
 Pro Leu Trp Phe Lys Asp Met Tyr Lys Pro Leu Ser Ala Thr Arg Ile
 145                 150                 155                 160
 Asn Asn His Ala Trp Lys Leu His Lys Lys Ser Ser Asn Glu Asp Lys
                 165                 170                 175    
 Ile Leu Asn Arg Asp Pro Gly Asp Ser Glu Ala Pro Thr Glu Glu Glu
             180                 185                 190        
 Glu Ser Glu Ala Leu Pro
         195            



      <210> 380
      <211> 220
      <212> PRT
      <213> Homo sapiens


      <400> 380
 Met Ala Asp Pro Asp Pro Arg Tyr Pro Arg Ser Ser Ile Glu Asp Asp
   1               5                  10                  15    
 Phe Asn Tyr Gly Ser Ser Val Ala Ser Ala Thr Val His Ile Arg Met
              20                  25                  30        
 Ala Phe Leu Arg Val Phe Leu Tyr Phe Glu Ser Val Arg Thr Phe Val
          35                  40                  45            
 His Glu Ser Pro Ala Leu Ile Leu Leu Phe Ala Leu Gly Ser Leu Gly
      50                  55                  60                
 Leu Ile Phe Ala Leu Thr Leu Asn Arg His Lys Tyr Pro Leu Asn Leu
  65                  70                  75                  80
 Tyr Leu Leu Phe Gly Phe Thr Leu Leu Glu Ala Leu Thr Val Ala Val
                  85                  90                  95    
 Val Val Thr Phe Tyr Asp Val Tyr Ile Ile Leu Gln Ala Phe Ile Leu
             100                 105                 110        
 Thr Thr Thr Val Phe Phe Gly Leu Thr Val Tyr Thr Leu Gln Ser Lys
         115                 120                 125            
 Lys Asp Phe Ser Lys Phe Gly Ala Gly Leu Phe Ala Leu Leu Trp Ile
     130                 135                 140                
 Leu Cys Leu Ser Gly Phe Leu Lys Phe Phe Phe Tyr Ser Glu Ile Met
 145                 150                 155                 160
 Glu Leu Val Leu Ala Ala Ala Gly Ala Leu Leu Phe Cys Gly Phe Ile
                 165                 170                 175    
 Ile Tyr Asp Thr His Ser Leu Met His Lys Leu Ser Pro Glu Glu Tyr
             180                 185                 190        
 Val Leu Ala Ala Ile Ser Leu Tyr Leu Asp Ile Ile Asn Leu Phe Leu
         195                 200                 205            
 His Leu Leu Arg Phe Leu Glu Ala Val Asn Lys Lys
     210                 215                 220



      <210> 381
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 381
 Met Ala Glu Gly Asp Asn Arg Ser Thr Asn Leu Leu Ala Ala Glu Thr
   1               5                  10                  15    
 Ala Ser Leu Glu Glu Gln Leu Gln Gly Trp Gly Glu Val Met Leu Met
              20                  25                  30        
 Ala Asp Lys Val Leu Arg Trp Glu Arg Ala Trp Phe Pro Pro Ala Ile
          35                  40                  45            
 Met Gly Val Val Ser Leu Val Phe Leu Ile Ile Tyr Tyr Leu Asp Pro
      50                  55                  60                
 Ser Val Leu Ser Gly Val Ser Cys Phe Val Met Phe Leu Cys Leu Ala
  65                  70                  75                  80
 Asp Tyr Leu Val Pro Ile Leu Ala Pro Arg Ile Phe Gly Ser Asn Lys
                  85                  90                  95    
 Trp Thr Thr Glu Gln Gln Gln Arg Phe His Glu Ile Cys Ser Asn Leu
             100                 105                 110        
 Val Lys Thr Arg Arg Arg Ala Val Gly Trp Trp Lys Arg Leu Phe Thr
         115                 120                 125            
 Leu Lys Glu Glu Val Gly Gln Gln Val His Asn Leu Leu Leu Thr Tyr
     130                 135                 140                
 Leu Ile Val Thr Ser Leu Leu Leu Leu Pro Gly Leu Asn Gln His Gly
 145                 150                 155                 160
 Ile Ile Leu Lys Tyr Ile Gly Met Ala Lys Arg Glu Ile Asn Lys Leu
                 165                 170                 175    
 Leu Lys Gln Lys Glu Lys Lys Asn Glu
             180                 185



      <210> 382
      <211> 766
      <212> PRT
      <213> Homo sapiens


      <400> 382
 Met Gly Gln Leu Val Gly Leu Val Glu Leu Pro His Leu Leu Gln His
   1               5                  10                  15    
 Gln Gly His Ser Leu Cys Thr Gly Gln Leu Thr Val Glu Leu Asn Ala
              20                  25                  30        
 His Gln Val Gly His Ala Val Gln Gln Pro Gly His Leu Leu Gln Leu
          35                  40                  45            
 Leu Ala Arg Val Leu His Thr Ala Arg Pro Gly Val Val Asp Glu Glu
      50                  55                  60                
 Asp Ala Val Gly Val Gly Cys Leu Glu Pro Ala Leu Pro Gly His Asp
  65                  70                  75                  80
 Asp Leu Val Ala Gln Leu Val Pro Arg Val Gly Leu Leu Leu Pro His
                  85                  90                  95    
 Leu Pro Gly Cys Leu Val Leu Leu Leu Phe Tyr Leu Leu His Leu His
             100                 105                 110        
 Asp Pro Lys His Phe Pro Ser Val Glu Asn Met Glu Ala Glu Arg Gly
         115                 120                 125            
 Pro Glu Arg Arg Pro Ala Glu Arg Ser Ser Pro Gly Gln Thr Pro Glu
     130                 135                 140                
 Glu Gly Ala Gln Ala Leu Ala Glu Phe Ala Ala Leu His Gly Pro Ala
 145                 150                 155                 160
 Leu Arg Ala Ser Gly Val Pro Glu Arg Tyr Trp Gly Arg Leu Leu His
                 165                 170                 175    
 Lys Leu Glu His Glu Val Phe Asp Ala Gly Glu Val Phe Gly Ile Met
             180                 185                 190        
 Gln Val Glu Glu Val Glu Glu Glu Glu Asp Glu Ala Ala Arg Glu Val
         195                 200                 205            
 Arg Lys Gln Gln Pro Asn Pro Gly Asn Glu Leu Cys Tyr Lys Val Ile
     210                 215                 220                
 Val Thr Arg Glu Ser Gly Leu Gln Ala Ala His Pro Asn Ser Ile Phe
 225                 230                 235                 240
 Leu Ile Asp His Ala Trp Thr Cys Arg Val Glu His Ala Arg Gln Gln
                 245                 250                 255    
 Leu Gln Gln Val Pro Gly Leu Leu His Arg Met Ala Asn Leu Met Gly
             260                 265                 270        
 Ile Glu Phe His Gly Glu Leu Pro Ser Thr Glu Ala Val Ala Leu Val
         275                 280                 285            
 Leu Glu Glu Met Trp Lys Phe Asn Gln Thr Tyr Gln Leu Ala His Gly
     290                 295                 300                
 Thr Ala Glu Glu Lys Met Pro Val Trp Tyr Ile Met Asp Glu Phe Gly
 305                 310                 315                 320
 Ser Arg Ile Gln His Ala Asp Val Pro Ser Phe Ala Thr Ala Pro Phe
                 325                 330                 335    
 Phe Tyr Met Pro Gln Gln Val Ala Tyr Thr Leu Leu Trp Pro Leu Arg
             340                 345                 350        
 Asp Leu Asp Thr Gly Glu Glu Val Thr Arg Asp Phe Ala Tyr Gly Glu
         355                 360                 365            
 Thr Asp Pro Leu Ile Arg Lys Cys Met Leu Leu Pro Trp Ala Pro Thr
     370                 375                 380                
 Asp Met Leu Asp Leu Ser Ser Cys Thr Pro Glu Pro Pro Ala Glu His
 385                 390                 395                 400
 Tyr Gln Ala Ile Leu Glu Glu Asn Lys Glu Lys Leu Pro Leu Asp Ile
                 405                 410                 415    
 Asn Pro Val Val His Pro His Gly His Ile Phe Lys Val Tyr Thr Asp
             420                 425                 430        
 Val Gln Gln Val Ala Ser Ser Leu Thr His Pro Arg Phe Thr Leu Thr
         435                 440                 445            
 Gln Ser Glu Ala Asp Ala Asp Ile Leu Phe Asn Phe Ser His Phe Lys
     450                 455                 460                
 Asp Tyr Arg Lys Leu Ser Gln Glu Arg Pro Gly Val Leu Leu Asn Gln
 465                 470                 475                 480
 Phe Pro Cys Glu Asn Leu Leu Thr Val Lys Asp Cys Leu Ala Ser Ile
                 485                 490                 495    
 Ala Arg Arg Ala Gly Gly Pro Glu Gly Pro Pro Trp Leu Pro Arg Thr
             500                 505                 510        
 Phe Asn Leu Arg Thr Glu Leu Pro Gln Phe Val Ser Tyr Phe Gln Gln
         515                 520                 525            
 Arg Glu Arg Trp Gly Glu Asp Asn His Trp Ile Cys Lys Pro Trp Asn
     530                 535                 540                
 Leu Ala Arg Ser Leu Asp Thr His Val Thr Lys Ser Leu His Ser Ile
 545                 550                 555                 560
 Ile Arg His Arg Glu Ser Thr Pro Lys Val Val Ser Lys Tyr Ile Glu
                 565                 570                 575    
 Ser Pro Val Leu Phe Leu Arg Glu Asp Val Gly Lys Val Lys Phe Asp
             580                 585                 590        
 Ile Arg Tyr Ile Val Leu Leu Arg Ser Val Arg Pro Leu Arg Leu Phe
         595                 600                 605            
 Val Tyr Asp Val Phe Trp Leu Arg Phe Ser Asn Arg Ala Phe Ala Leu
     610                 615                 620                
 Asn Asp Leu Asp Asp Tyr Glu Lys His Phe Thr Val Met Asn Tyr Asp
 625                 630                 635                 640
 Pro Asp Val Val Leu Lys Gln Val His Cys Glu Glu Phe Ile Pro Glu
                 645                 650                 655    
 Phe Glu Lys Gln Tyr Pro Glu Phe Pro Trp Thr Asp Val Gln Ala Glu
             660                 665                 670        
 Ile Phe Arg Ala Phe Thr Glu Leu Phe Gln Val Ala Cys Ala Lys Pro
         675                 680                 685            
 Pro Pro Leu Gly Leu Cys Asp Tyr Pro Ser Ser Arg Ala Met Tyr Ala
     690                 695                 700                
 Val Asp Leu Met Leu Lys Trp Asp Asn Gly Pro Asp Gly Arg Arg Val
 705                 710                 715                 720
 Met Gln Pro Gln Ile Leu Glu Val Asn Phe Asn Pro Asp Cys Glu Arg
                 725                 730                 735    
 Ala Cys Arg Tyr His Pro Thr Phe Phe Asn Asp Val Phe Ser Thr Leu
             740                 745                 750        
 Phe Leu Asp Gln Pro Gly Gly Cys His Val Thr Cys Leu Val
         755                 760                 765    



      <210> 383
      <211> 422
      <212> PRT
      <213> Homo sapiens


      <400> 383
 Met Gln Gln Pro Gln Pro Gln Gly Gln Gln Gln Pro Gly Pro Gly Gln
   1               5                  10                  15    
 Gln Leu Gly Gly Gln Gly Ala Ala Pro Gly Ala Gly Gly Gly Pro Gly
              20                  25                  30        
 Gly Gly Pro Gly Pro Gly Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu
          35                  40                  45            
 Glu Ser Ile Phe His Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala
      50                  55                  60                
 Cys Leu Asp Glu Leu Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly
  65                  70                  75                  80
 Ala Gly Ala Gly Ala Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser
                  85                  90                  95    
 Val Pro Gly Asp Pro Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr
             100                 105                 110        
 Pro Ala Val Pro Pro Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu
         115                 120                 125            
 Ala Ala Val Leu Glu Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu
     130                 135                 140                
 Leu Leu Gln His Leu Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr
 145                 150                 155                 160
 Asn Leu Pro Gln His Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro
                 165                 170                 175    
 Ala Glu Gln Cys Thr Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu
             180                 185                 190        
 Glu Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu
         195                 200                 205            
 Glu Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys
     210                 215                 220                
 Glu Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp
 225                 230                 235                 240
 Tyr Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu
                 245                 250                 255    
 Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly
             260                 265                 270        
 Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val
         275                 280                 285            
 Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln
     290                 295                 300                
 Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser
 305                 310                 315                 320
 Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser
                 325                 330                 335    
 Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met
             340                 345                 350        
 Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser
         355                 360                 365            
 Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val
     370                 375                 380                
 Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln
 385                 390                 395                 400
 Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr
                 405                 410                 415    
 Pro Pro Lys Glu Asp Gly
             420        



      <210> 384
      <211> 478
      <212> PRT
      <213> Homo sapiens


      <400> 384
 Met Gly Ser Arg Trp Ser Ser Glu Glu Glu Arg Gln Pro Leu Leu Gly
   1               5                  10                  15    
 Pro Gly Leu Gly Pro Gly Leu Gly Ala Ser Trp Arg Ser Arg Glu Ala
              20                  25                  30        
 Ala Ala Ala Ala Leu Pro Ala Ala Val Pro Gly Pro Gly Arg Val Tyr
          35                  40                  45            
 Gly Arg Arg Trp Leu Val Leu Leu Leu Phe Ser Leu Leu Ala Phe Val
      50                  55                  60                
 Gln Gly Leu Val Trp Asn Thr Trp Gly Pro Ile Gln Asn Ser Ala Arg
  65                  70                  75                  80
 Gln Ala Tyr Gly Phe Ser Ser Trp Asp Ile Ala Leu Leu Val Leu Trp
                  85                  90                  95    
 Gly Pro Ile Gly Phe Leu Pro Cys Phe Ala Phe Met Trp Leu Leu Asp
             100                 105                 110        
 Lys Arg Gly Leu Arg Ile Thr Val Leu Leu Thr Ser Phe Leu Met Val
         115                 120                 125            
 Leu Gly Thr Gly Leu Arg Cys Ile Pro Ile Ser Asp Leu Ile Leu Lys
     130                 135                 140                
 Arg Arg Leu Ile His Gly Gly Gln Met Leu Asn Gly Leu Ala Gly Pro
 145                 150                 155                 160
 Thr Val Met Asn Ala Ala Pro Phe Leu Ser Thr Thr Trp Phe Ser Ala
                 165                 170                 175    
 Asp Glu Arg Ala Thr Ala Thr Ala Ile Ala Ser Met Leu Ser Tyr Leu
             180                 185                 190        
 Gly Gly Ala Cys Ala Phe Leu Val Gly Pro Leu Val Val Pro Ala Pro
         195                 200                 205            
 Asn Gly Thr Ser Pro Leu Leu Ala Ala Glu Ser Ser Arg Ala His Ile
     210                 215                 220                
 Lys Asp Arg Ile Glu Ala Val Leu Tyr Ala Glu Phe Gly Val Val Cys
 225                 230                 235                 240
 Leu Ile Phe Ser Ala Thr Leu Ala Tyr Phe Pro Pro Arg Pro Pro Leu
                 245                 250                 255    
 Pro Pro Ser Val Ala Ala Ala Ser Gln Arg Leu Ser Tyr Arg Arg Ser
             260                 265                 270        
 Val Cys Arg Leu Leu Ser Asn Phe Arg Phe Leu Met Ile Ala Leu Ala
         275                 280                 285            
 Tyr Ala Ile Pro Leu Gly Val Phe Ala Gly Trp Ser Gly Val Leu Asp
     290                 295                 300                
 Leu Ile Leu Thr Pro Ala His Val Ser Gln Val Asp Ala Gly Trp Ile
 305                 310                 315                 320
 Gly Phe Trp Ser Ile Val Gly Gly Cys Val Val Gly Ile Ala Met Ala
                 325                 330                 335    
 Arg Phe Ala Asp Phe Ile Arg Gly Met Leu Lys Leu Ile Leu Leu Leu
             340                 345                 350        
 Leu Phe Ser Gly Ala Thr Leu Ser Ser Thr Trp Phe Thr Leu Thr Cys
         355                 360                 365            
 Leu Asn Ser Ile Thr His Leu Pro Leu Thr Thr Val Thr Leu Tyr Ala
     370                 375                 380                
 Ser Cys Ile Leu Leu Gly Val Phe Leu Asn Ser Ser Val Pro Ile Phe
 385                 390                 395                 400
 Phe Glu Leu Phe Val Glu Thr Val Tyr Pro Val Pro Glu Gly Ile Thr
                 405                 410                 415    
 Cys Gly Val Val Thr Phe Leu Ser Asn Met Phe Met Gly Val Leu Leu
             420                 425                 430        
 Phe Phe Leu Thr Phe Tyr His Thr Glu Leu Ser Trp Phe Asn Trp Cys
         435                 440                 445            
 Leu Pro Gly Ser Cys Leu Leu Ser Leu Leu Leu Ile Leu Cys Phe Arg
     450                 455                 460                
 Glu Ser Tyr Asp Arg Leu Tyr Leu Asp Val Val Val Ser Val
 465                 470                 475            



      <210> 385
      <211> 552
      <212> PRT
      <213> Homo sapiens


      <400> 385
 Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn
   1               5                  10                  15    
 Glu Glu Arg Lys Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu
              20                  25                  30        
 Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg
          35                  40                  45            
 Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe
      50                  55                  60                
 Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg
  65                  70                  75                  80
 Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala
                  85                  90                  95    
 Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr
             100                 105                 110        
 Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu
         115                 120                 125            
 Gly Phe Ser Ser Pro Cys Thr Phe Ala Ala Ala Val Ser Gly Ala Asn
     130                 135                 140                
 Gly Ser Thr Leu Trp Glu Arg Pro Val Ala Gln Asp Val Ala Leu Val
 145                 150                 155                 160
 Glu Cys Ala Val Pro Gln Pro Arg Gly Ser Glu Ala Pro Ser Ala Cys
                 165                 170                 175    
 Ile Leu Val Gly Arg Pro Ser Ser Phe Ile Ala Val Asn Leu Phe Thr
             180                 185                 190        
 Gly Glu Thr Leu Trp Asn His Ser Ser Ser Phe Ser Gly Asn Ala Ser
         195                 200                 205            
 Ile Leu Ser Pro Leu Leu Gln Val Pro Asp Val Asp Gly Asp Gly Ala
     210                 215                 220                
 Pro Asp Leu Leu Val Leu Thr Gln Glu Arg Glu Glu Val Ser Gly His
 225                 230                 235                 240
 Leu Tyr Ser Gly Ser Thr Gly His Gln Ile Gly Leu Arg Gly Ser Leu
                 245                 250                 255    
 Gly Val Asp Gly Glu Ser Gly Phe Leu Leu His Val Thr Arg Thr Gly
             260                 265                 270        
 Ala His Tyr Ile Leu Phe Pro Cys Ala Ser Ser Leu Cys Gly Cys Ser
         275                 280                 285            
 Val Lys Gly Leu Tyr Glu Lys Val Thr Gly Ser Gly Gly Pro Phe Lys
     290                 295                 300                
 Ser Asp Pro His Trp Glu Ser Met Leu Asn Ala Thr Thr Arg Arg Met
 305                 310                 315                 320
 Leu Ser His Ser Ser Gly Ala Val Arg Tyr Leu Met His Val Pro Gly
                 325                 330                 335    
 Asn Ala Gly Ala Asp Val Leu Leu Val Gly Ser Glu Ala Phe Val Leu
             340                 345                 350        
 Leu Asp Gly Gln Glu Leu Thr Pro Arg Trp Thr Pro Lys Ala Ala His
         355                 360                 365            
 Val Leu Arg Lys Pro Ile Phe Gly Arg Tyr Lys Pro Asp Thr Leu Ala
     370                 375                 380                
 Val Ala Val Glu Asn Gly Thr Gly Thr Asp Arg Gln Ile Leu Phe Leu
 385                 390                 395                 400
 Asp Leu Gly Thr Gly Ala Val Leu Cys Ser Leu Ala Leu Pro Ser Leu
                 405                 410                 415    
 Pro Gly Gly Pro Leu Ser Ala Ser Leu Pro Thr Ala Asp His Arg Ser
             420                 425                 430        
 Ala Phe Phe Phe Trp Gly Leu His Glu Leu Gly Ser Thr Ser Glu Thr
         435                 440                 445            
 Glu Thr Gly Glu Ala Arg His Ser Leu Tyr Met Phe His Pro Thr Leu
     450                 455                 460                
 Pro Arg Val Leu Leu Glu Leu Ala Asn Val Ser Thr His Ile Val Ala
 465                 470                 475                 480
 Phe Asp Ala Val Leu Phe Glu Pro Ser Arg His Ala Ala Tyr Ile Leu
                 485                 490                 495    
 Leu Thr Gly Pro Ala Asp Ser Glu Ala Pro Gly Leu Val Ser Val Ile
             500                 505                 510        
 Lys His Lys Val Arg Asp Leu Val Pro Ser Ser Arg Val Val Arg Leu
         515                 520                 525            
 Gly Glu Gly Gly Pro Asp Ser Asp Gln Ala Ile Arg Asp Arg Phe Ser
     530                 535                 540                
 Arg Leu Arg Tyr Gln Ser Glu Ala
 545                 550        



      <210> 386
      <211> 543
      <212> PRT
      <213> Homo sapiens


      <400> 386
 Met Leu Asp His Lys Asp Leu Glu Ala Glu Ile His Pro Leu Lys Asn
   1               5                  10                  15    
 Glu Glu Arg Lys Ser Gln Glu Asn Leu Gly Asn Pro Ser Lys Asn Glu
              20                  25                  30        
 Asp Asn Val Lys Ser Ala Pro Pro Gln Ser Arg Leu Ser Arg Cys Arg
          35                  40                  45            
 Ala Ala Ala Phe Phe Leu Ser Leu Phe Leu Cys Leu Phe Val Val Phe
      50                  55                  60                
 Val Val Ser Phe Val Ile Pro Cys Pro Asp Arg Pro Ala Ser Gln Arg
  65                  70                  75                  80
 Met Trp Arg Ile Asp Tyr Ser Ala Ala Val Ile Tyr Asp Phe Leu Ala
                  85                  90                  95    
 Val Asp Asp Ile Asn Gly Asp Arg Ile Gln Asp Val Leu Phe Leu Tyr
             100                 105                 110        
 Lys Asn Thr Asn Ser Ser Asn Asn Phe Ser Arg Ser Cys Val Asp Glu
         115                 120                 125            
 Ala Ala Val Ser Gly Ala Asn Gly Ser Thr Leu Trp Glu Arg Pro Val
     130                 135                 140                
 Ala Gln Asp Val Ala Leu Val Glu Cys Ala Val Pro Gln Pro Arg Gly
 145                 150                 155                 160
 Ser Glu Ala Pro Ser Ala Cys Ile Leu Val Gly Arg Pro Ser Ser Phe
                 165                 170                 175    
 Ile Ala Val Asn Leu Phe Thr Gly Glu Thr Leu Trp Asn His Ser Ser
             180                 185                 190        
 Ser Phe Ser Gly Asn Ala Ser Ile Leu Ser Pro Leu Leu Gln Val Pro
         195                 200                 205            
 Asp Val Asp Gly Asp Gly Ala Pro Asp Leu Leu Val Leu Thr Gln Glu
     210                 215                 220                
 Arg Glu Glu Val Ser Gly His Leu Tyr Ser Gly Ser Thr Gly His Gln
 225                 230                 235                 240
 Ile Gly Leu Arg Gly Ser Leu Gly Val Asp Gly Glu Ser Gly Phe Leu
                 245                 250                 255    
 Leu His Val Thr Arg Thr Gly Ala His Tyr Ile Leu Phe Pro Cys Ala
             260                 265                 270        
 Ser Ser Leu Cys Gly Cys Ser Val Lys Gly Leu Tyr Glu Lys Val Thr
         275                 280                 285            
 Gly Ser Gly Gly Pro Phe Lys Ser Asp Pro His Trp Glu Ser Met Leu
     290                 295                 300                
 Asn Ala Thr Thr Arg Arg Met Leu Ser His Ser Ser Gly Ala Val Arg
 305                 310                 315                 320
 Tyr Leu Met His Val Pro Gly Asn Ala Gly Ala Asp Val Leu Leu Val
                 325                 330                 335    
 Gly Ser Glu Ala Phe Val Leu Leu Asp Gly Gln Glu Leu Thr Pro Arg
             340                 345                 350        
 Trp Thr Pro Lys Ala Ala His Val Leu Arg Lys Pro Ile Phe Gly Arg
         355                 360                 365            
 Tyr Lys Pro Asp Thr Leu Ala Val Ala Val Glu Asn Gly Thr Gly Thr
     370                 375                 380                
 Asp Arg Gln Ile Leu Phe Leu Asp Leu Gly Thr Gly Ala Val Leu Cys
 385                 390                 395                 400
 Ser Leu Ala Leu Pro Ser Leu Pro Gly Gly Pro Leu Ser Ala Ser Leu
                 405                 410                 415    
 Pro Thr Ala Asp His Arg Ser Ala Phe Phe Phe Trp Gly Leu His Glu
             420                 425                 430        
 Leu Gly Ser Thr Ser Glu Thr Glu Thr Gly Glu Ala Arg His Ser Leu
         435                 440                 445            
 Tyr Met Phe His Pro Thr Leu Pro Arg Val Leu Leu Glu Leu Ala Asn
     450                 455                 460                
 Val Ser Thr His Ile Val Ala Phe Asp Ala Val Leu Phe Glu Pro Ser
 465                 470                 475                 480
 Arg His Ala Ala Tyr Ile Leu Leu Thr Gly Pro Ala Asp Ser Glu Ala
                 485                 490                 495    
 Pro Gly Leu Val Ser Val Ile Lys His Lys Val Arg Asp Leu Val Pro
             500                 505                 510        
 Ser Ser Arg Val Val Arg Leu Gly Glu Gly Gly Pro Asp Ser Asp Gln
         515                 520                 525            
 Ala Ile Arg Asp Arg Phe Ser Arg Leu Arg Tyr Gln Ser Glu Ala
     530                 535                 540            



      <210> 387
      <211> 107
      <212> PRT
      <213> Homo sapiens


      <400> 387
 Met Thr Val Thr Gly Phe Phe Ile Gly Gly Pro Ser Asn Met Ile Ser
   1               5                  10                  15    
 Ser Ala Ile Ser Ala Asp Leu Gly Arg Gln Glu Leu Ile Gln Arg Ser
              20                  25                  30        
 Ser Glu Ala Leu Ala Thr Val Thr Gly Ile Val Asp Gly Ser Gly Ser
          35                  40                  45            
 Ile Gly Ala Ala Val Gly Gln Tyr Leu Val Ser Leu Ile Arg Asp Lys
      50                  55                  60                
 Leu Gly Trp Met Trp Val Phe Tyr Phe Phe Ile Leu Met Thr Ser Cys
  65                  70                  75                  80
 Thr Ile Val Phe Ile Ser Pro Leu Ile Val Arg Glu Ile Phe Ser Leu
                  85                  90                  95    
 Val Leu Arg Arg Gln Ala His Ile Leu Arg Glu
             100                 105        



      <210> 388
      <211> 511
      <212> PRT
      <213> Homo sapiens


      <400> 388
 Met Glu Ser Thr Gly Ser Val Gly Glu Ala Pro Gly Gly Pro Arg Val
   1               5                  10                  15    
 Leu Val Val Gly Gly Gly Ile Ala Gly Leu Gly Ala Ala Gln Arg Leu
              20                  25                  30        
 Cys Gly His Ser Ala Phe Pro His Leu Arg Val Leu Glu Ala Thr Ala
          35                  40                  45            
 Arg Ala Gly Gly Arg Ile Arg Ser Glu Arg Cys Phe Gly Gly Val Val
      50                  55                  60                
 Glu Val Gly Ala His Trp Ile His Gly Pro Ser Arg Gly Asn Pro Val
  65                  70                  75                  80
 Phe Gln Leu Ala Ala Glu Tyr Gly Leu Leu Gly Glu Lys Glu Leu Ser
                  85                  90                  95    
 Gln Glu Asn Gln Leu Val Glu Thr Gly Gly His Val Gly Leu Pro Ser
             100                 105                 110        
 Val Ser Tyr Ala Ser Ser Gly Ala Ser Val Ser Leu Gln Leu Val Ala
         115                 120                 125            
 Glu Met Ala Thr Leu Phe Tyr Gly Leu Ile Asp Gln Thr Arg Glu Phe
     130                 135                 140                
 Leu His Ala Ala Glu Thr Pro Val Pro Ser Val Gly Glu Tyr Leu Lys
 145                 150                 155                 160
 Lys Glu Ile Gly Gln His Val Ala Gly Trp Thr Glu Asp Glu Glu Thr
                 165                 170                 175    
 Arg Lys Leu Lys Leu Ala Val Leu Asn Ser Phe Phe Asn Leu Glu Cys
             180                 185                 190        
 Cys Val Ser Gly Thr His Ser Met Asp Leu Val Ala Leu Ala Pro Phe
         195                 200                 205            
 Gly Glu Tyr Thr Val Leu Pro Gly Leu Asp Cys Thr Phe Ser Lys Gly
     210                 215                 220                
 Tyr Gln Gly Leu Thr Asn Cys Met Met Ala Ala Leu Pro Glu Asp Thr
 225                 230                 235                 240
 Val Val Phe Glu Lys Pro Val Lys Thr Ile His Trp Asn Gly Ser Phe
                 245                 250                 255    
 Gln Glu Ala Ala Phe Pro Gly Glu Thr Phe Pro Val Ser Val Glu Cys
             260                 265                 270        
 Glu Asp Gly Asp Arg Phe Pro Ala His His Val Ile Val Thr Val Pro
         275                 280                 285            
 Leu Gly Phe Leu Arg Glu His Leu Asp Thr Phe Phe Asp Pro Pro Leu
     290                 295                 300                
 Pro Ala Glu Lys Ala Glu Ala Ile Arg Lys Ile Gly Phe Gly Thr Asn
 305                 310                 315                 320
 Asn Lys Ile Phe Leu Glu Phe Glu Glu Pro Phe Trp Glu Pro Asp Cys
                 325                 330                 335    
 Gln Leu Ile Gln Leu Val Trp Glu Asp Thr Ser Pro Leu Glu Asp Ala
             340                 345                 350        
 Ala Pro Glu Leu Gln Asp Ala Trp Phe Arg Lys Leu Ile Gly Phe Val
         355                 360                 365            
 Val Leu Pro Ala Phe Ala Ser Val His Val Leu Cys Gly Phe Ile Ala
     370                 375                 380                
 Gly Leu Glu Ser Glu Phe Met Glu Thr Leu Ser Asp Glu Glu Val Leu
 385                 390                 395                 400
 Leu Cys Leu Thr Gln Val Leu Arg Arg Val Thr Gly Asn Pro Arg Leu
                 405                 410                 415    
 Pro Ala Pro Lys Ser Val Leu Arg Ser Arg Trp His Ser Ala Pro Tyr
             420                 425                 430        
 Thr Arg Gly Ser Tyr Ser Tyr Val Ala Val Gly Ser Thr Gly Gly Asp
         435                 440                 445            
 Leu Asp Leu Leu Ala Gln Pro Leu Pro Ala Asp Gly Ala Gly Ala Gln
     450                 455                 460                
 Leu Gln Ile Leu Phe Ala Gly Glu Ala Thr His Arg Thr Phe Tyr Ser
 465                 470                 475                 480
 Thr Thr His Gly Ala Leu Leu Ser Gly Trp Arg Glu Ala Asp Arg Leu
                 485                 490                 495    
 Leu Ser Leu Trp Ala Pro Gln Val Gln Gln Pro Arg Pro Arg Leu
             500                 505                 510    



      <210> 389
      <211> 1307
      <212> PRT
      <213> Homo sapiens


      <400> 389
 Met Ser Gly Gly Gly Gly Gly Gly Gly Ser Ala Pro Ser Arg Phe Ala
   1               5                  10                  15    
 Asp Tyr Phe Val Ile Cys Gly Leu Asp Thr Glu Thr Gly Leu Glu Pro
              20                  25                  30        
 Asp Glu Leu Ser Ala Leu Cys Gln Tyr Ile Gln Ala Ser Lys Ala Arg
          35                  40                  45            
 Asp Gly Ala Ser Pro Phe Ile Ser Ser Thr Thr Glu Gly Glu Asn Phe
      50                  55                  60                
 Glu Gln Thr Pro Leu Arg Arg Thr Phe Lys Ser Lys Val Leu Ala Arg
  65                  70                  75                  80
 Tyr Pro Glu Asn Val Glu Trp Asn Pro Phe Asp Gln Asp Ala Val Gly
                  85                  90                  95    
 Met Leu Cys Met Pro Lys Gly Leu Ala Phe Lys Thr Gln Ala Asp Pro
             100                 105                 110        
 Arg Glu Pro Gln Phe His Ala Phe Ile Ile Thr Arg Glu Asp Gly Ser
         115                 120                 125            
 Arg Thr Phe Gly Phe Ala Leu Thr Phe Tyr Glu Glu Val Thr Ser Lys
     130                 135                 140                
 Gln Ile Cys Ser Ala Met Gln Thr Leu Tyr His Met His Asn Ala Glu
 145                 150                 155                 160
 Tyr Asp Val Leu His Ala Pro Pro Ala Asp Asp Arg Asp Gln Ser Ser
                 165                 170                 175    
 Met Glu Asp Gly Glu Asp Thr Pro Val Thr Lys Leu Gln Arg Phe Asn
             180                 185                 190        
 Ser Tyr Asp Ile Ser Arg Asp Thr Leu Tyr Val Ser Lys Cys Ile Cys
         195                 200                 205            
 Leu Ile Thr Pro Met Ser Phe Met Lys Ala Cys Arg Ser Val Leu Gln
     210                 215                 220                
 Gln Leu His Gln Ala Val Thr Ser Pro Gln Pro Pro Pro Leu Pro Leu
 225                 230                 235                 240
 Glu Ser Tyr Ile Tyr Asn Val Leu Tyr Glu Val Pro Leu Pro Pro Pro
                 245                 250                 255    
 Gly Arg Ser Leu Lys Phe Ser Gly Val Tyr Gly Pro Ile Ile Cys Gln
             260                 265                 270        
 Arg Pro Ser Thr Asn Glu Leu Pro Leu Phe Asp Phe Pro Val Lys Glu
         275                 280                 285            
 Val Phe Glu Leu Leu Gly Val Glu Asn Val Phe Gln Leu Phe Thr Cys
     290                 295                 300                
 Ala Leu Leu Glu Phe Gln Ile Leu Leu Tyr Ser Gln His Tyr Gln Arg
 305                 310                 315                 320
 Leu Met Thr Val Ala Glu Thr Ile Thr Ala Leu Met Phe Pro Phe Gln
                 325                 330                 335    
 Trp Gln His Val Tyr Val Pro Ile Leu Pro Ala Ser Leu Leu His Phe
             340                 345                 350        
 Leu Asp Ala Pro Val Pro Tyr Leu Met Gly Leu His Ser Asn Gly Leu
         355                 360                 365            
 Asp Asp Arg Ser Lys Leu Glu Leu Pro Gln Glu Ala Asn Leu Cys Phe
     370                 375                 380                
 Val Asp Ile Asp Asn His Phe Ile Glu Leu Pro Glu Asp Leu Pro Gln
 385                 390                 395                 400
 Phe Pro Asn Lys Leu Glu Phe Val Gln Glu Val Ser Glu Ile Leu Met
                 405                 410                 415    
 Ala Phe Gly Ile Pro Pro Glu Gly Asn Leu His Cys Ser Glu Ser Ala
             420                 425                 430        
 Ser Lys Leu Lys Arg Leu Arg Ala Ser Glu Leu Val Ser Asp Lys Arg
         435                 440                 445            
 Asn Gly Asn Ile Ala Gly Ser Pro Leu His Ser Tyr Glu Leu Leu Lys
     450                 455                 460                
 Glu Asn Glu Thr Ile Ala Arg Leu Gln Ala Leu Val Lys Arg Thr Gly
 465                 470                 475                 480
 Val Ser Leu Glu Lys Leu Glu Val Arg Glu Asp Pro Ser Ser Asn Lys
                 485                 490                 495    
 Asp Leu Lys Val Gln Cys Asp Glu Glu Glu Leu Arg Ile Tyr Gln Leu
             500                 505                 510        
 Asn Ile Gln Ile Arg Glu Val Phe Ala Asn Arg Phe Thr Gln Met Phe
         515                 520                 525            
 Ala Asp Tyr Glu Val Phe Val Ile Gln Pro Ser Gln Asp Lys Glu Ser
     530                 535                 540                
 Trp Phe Thr Asn Arg Glu Gln Met Gln Asn Phe Asp Lys Ala Ser Phe
 545                 550                 555                 560
 Leu Ser Asp Gln Pro Glu Pro Tyr Leu Pro Phe Leu Ser Arg Phe Leu
                 565                 570                 575    
 Glu Thr Gln Met Phe Ala Ser Phe Ile Asp Asn Lys Ile Met Cys His
             580                 585                 590        
 Asp Asp Asp Asp Lys Asp Pro Val Leu Arg Val Phe Asp Ser Arg Val
         595                 600                 605            
 Asp Lys Ile Arg Leu Leu Asn Val Arg Thr Pro Thr Leu Arg Thr Ser
     610                 615                 620                
 Met Tyr Gln Lys Cys Thr Thr Val Asp Glu Ala Glu Lys Ala Ile Glu
 625                 630                 635                 640
 Leu Arg Leu Ala Lys Ile Asp His Thr Ala Ile His Pro His Leu Leu
                 645                 650                 655    
 Asp Met Lys Ile Gly Gln Gly Lys Tyr Glu Pro Gly Phe Phe Pro Lys
             660                 665                 670        
 Leu Gln Ser Asp Val Leu Ser Thr Gly Pro Ala Ser Asn Lys Trp Thr
         675                 680                 685            
 Lys Arg Asn Ala Pro Ala Gln Trp Arg Arg Lys Asp Arg Gln Lys Gln
     690                 695                 700                
 His Thr Glu His Leu Arg Leu Asp Asn Asp Gln Arg Glu Lys Tyr Ile
 705                 710                 715                 720
 Gln Glu Ala Arg Thr Met Gly Ser Thr Ile Arg Gln Pro Lys Leu Ser
                 725                 730                 735    
 Asn Leu Ser Pro Ser Val Ile Ala Gln Thr Asn Trp Lys Phe Val Glu
             740                 745                 750        
 Gly Leu Leu Lys Glu Cys Arg Asn Lys Thr Lys Arg Met Leu Val Glu
         755                 760                 765            
 Lys Met Gly Arg Glu Ala Val Glu Leu Gly His Gly Glu Val Asn Ile
     770                 775                 780                
 Thr Gly Val Glu Glu Asn Thr Leu Ile Ala Ser Leu Cys Asp Leu Leu
 785                 790                 795                 800
 Glu Arg Ile Trp Ser His Gly Leu Gln Val Lys Gln Gly Lys Ser Ala
                 805                 810                 815    
 Leu Trp Ser His Leu Leu His Tyr Gln Asp Asn Arg Gln Arg Lys Leu
             820                 825                 830        
 Thr Ser Gly Ser Leu Ser Thr Ser Gly Ile Leu Leu Asp Ser Glu Arg
         835                 840                 845            
 Arg Lys Ser Asp Ala Ser Ser Leu Met Pro Pro Leu Arg Ile Ser Leu
     850                 855                 860                
 Ile Gln Asp Met Arg His Ile Gln Asn Ile Gly Glu Ile Lys Thr Asp
 865                 870                 875                 880
 Val Gly Lys Ala Arg Ala Trp Val Arg Leu Ser Met Glu Lys Lys Leu
                 885                 890                 895    
 Leu Ser Arg His Leu Lys Gln Leu Leu Ser Asp His Glu Leu Thr Lys
             900                 905                 910        
 Lys Leu Tyr Lys Arg Tyr Ala Phe Leu Arg Cys Asp Asp Glu Lys Glu
         915                 920                 925            
 Gln Phe Leu Tyr His Leu Leu Ser Phe Asn Ala Val Asp Tyr Phe Cys
     930                 935                 940                
 Phe Thr Asn Val Phe Thr Thr Ile Leu Ile Pro Tyr His Ile Leu Ile
 945                 950                 955                 960
 Val Pro Ser Lys Lys Leu Gly Gly Ser Met Phe Thr Ala Asn Pro Trp
                 965                 970                 975    
 Ile Cys Ile Ser Gly Glu Leu Gly Glu Thr Gln Ile Met Gln Ile Pro
             980                 985                 990        
 Arg Asn Val Leu Glu Met Thr Phe Glu Cys Gln Asn Leu Gly Lys Leu
         995                1000                1005            
 Thr Thr Val Gln Ile Gly His Asp Asn Ser Gly Leu Tyr Ala Lys Trp
    1010                1015                1020                
 Leu Val Glu Tyr Val Met Val Arg Asn Glu Ile Thr Gly His Thr Tyr
1025                1030                1035                1040
 Lys Phe Pro Cys Gly Arg Trp Leu Gly Lys Gly Met Asp Asp Gly Ser
                1045                1050                1055    
 Leu Glu Arg Ile Leu Val Gly Glu Leu Leu Thr Ser Gln Pro Glu Val
            1060                1065                1070        
 Asp Glu Arg Pro Cys Arg Thr Pro Pro Leu Gln Gln Ser Pro Ser Val
        1075                1080                1085            
 Ile Arg Arg Leu Val Thr Ile Ser Pro Asn Asn Lys Pro Lys Leu Asn
    1090                1095                1100                
 Thr Gly Gln Ile Gln Glu Ser Ile Gly Glu Ala Val Asn Gly Ile Val
1105                1110                1115                1120
 Lys His Phe His Lys Pro Glu Lys Glu Arg Gly Ser Leu Thr Leu Leu
                1125                1130                1135    
 Leu Cys Gly Glu Cys Gly Leu Val Ser Ala Leu Glu Gln Ala Phe Gln
            1140                1145                1150        
 His Gly Phe Lys Ser Pro Arg Leu Phe Lys Asn Val Phe Ile Trp Asp
        1155                1160                1165            
 Phe Leu Glu Lys Ala Gln Thr Tyr Tyr Glu Thr Leu Glu Lys Asn Glu
    1170                1175                1180                
 Val Val Pro Glu Glu Asn Trp His Thr Arg Ala Arg Asn Phe Cys Arg
1185                1190                1195                1200
 Phe Val Thr Ala Ile Asn Asn Thr Pro Arg Asn Ile Gly Lys Asp Gly
                1205                1210                1215    
 Lys Phe Gln Met Leu Val Cys Leu Gly Ala Arg Gly Ile Met Lys Ile
            1220                1225                1230        
 Lys Ser Leu Met Ser Val Pro Ala His Ala Glu Cys Tyr Val Arg Asp
        1235                1240                1245            
 His Leu Leu His His Trp Ile Ala Leu Leu Ala Asp Cys Pro Ile Thr
    1250                1255                1260                
 Ala His Met Tyr Glu Asp Val Ala Leu Ile Lys Asp His Thr Leu Val
1265                1270                1275                1280
 Asn Ser Leu Ile Arg Val Leu Gln Thr Leu Gln Glu Phe Asn Ile Thr
                1285                1290                1295    
 Leu Glu Thr Ser Leu Val Lys Gly Ile Asp Ile
            1300                1305        



      <210> 390
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 390
 Met Gln Arg Arg Ser Arg Gly Ile Asn Thr Gly Leu Ile Leu Leu Leu
   1               5                  10                  15    
 Ser Gln Ile Phe His Val Gly Ile Asn Asn Ile Pro Pro Val Thr Leu
              20                  25                  30        
 Ala Thr Leu Ala Leu Asn Ile Trp Phe Phe Leu Asn Pro Gln Lys Pro
          35                  40                  45            
 Leu Tyr Ser Ser Cys Leu Ser Val Glu Lys Cys Tyr Gln Gln Lys Asp
      50                  55                  60                
 Trp Gln Arg Leu Leu Leu Ser Pro Leu His His Ala Asp Asp Trp His
  65                  70                  75                  80
 Leu Tyr Phe Asn Met Ala Ser Met Leu Trp Lys Gly Ile Asn Leu Glu
                  85                  90                  95    
 Arg Arg Leu Gly Ser Arg Trp Phe Ala Tyr Val Ile Thr Ala Phe Ser
             100                 105                 110        
 Val Leu Thr Gly Val Val Tyr Leu Leu Leu Gln Phe Ala Val Ala Glu
         115                 120                 125            
 Phe Met Asp Glu Pro Asp Phe Lys Arg Ser Cys Ala Val Gly Phe Ser
     130                 135                 140                
 Gly Val Leu Phe Ala Leu Lys Val Leu Asn Asn His Tyr Cys Pro Gly
 145                 150                 155                 160
 Gly Phe Val Asn Ile Leu Gly Phe Pro Val Pro Asn Arg Phe Ala Cys
                 165                 170                 175    
 Trp Val Glu Leu Val Ala Ile His Leu Phe Ser Pro Gly Thr Ser Phe
             180                 185                 190        
 Ala Gly His Leu Ala Gly Ile Leu Val Gly Leu Met Tyr Thr Gln Gly
         195                 200                 205            
 Pro Leu Lys Lys Ile Met Glu Ala Cys Ala Gly Gly Phe Ser Ser Ser
     210                 215                 220                
 Val Gly Tyr Pro Gly Arg Gln Tyr Tyr Phe Asn Ser Ser Gly Ser Ser
 225                 230                 235                 240
 Gly Tyr Gln Asp Tyr Tyr Pro His Gly Arg Pro Asp His Tyr Glu Glu
                 245                 250                 255    
 Ala Pro Arg Asn Tyr Asp Thr Tyr Thr Ala Gly Leu Ser Glu Glu Glu
             260                 265                 270        
 Gln Leu Glu Arg Ala Leu Gln Ala Ser Leu Trp Asp Arg Gly Asn Thr
         275                 280                 285            
 Arg Asn Ser Pro Pro Pro Tyr Gly Phe His Leu Ser Pro Glu Glu Met
     290                 295                 300                
 Arg Arg Gln Arg Leu His Arg Phe Asp Ser Gln
 305                 310                 315



      <210> 391
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 391
 Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu Leu Gln Ser Phe
   1               5                  10                  15    
 Glu Arg Arg Phe Leu Ala Ala Arg Thr Leu Arg Ser Phe Pro Trp Gln
              20                  25                  30        
 Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu Leu Leu Arg
          35                  40                  45            
 Asp Ile Leu His Lys Thr Val Lys His Pro Val Cys Val Lys His Pro
      50                  55                  60                
 Pro Ser Val Lys Tyr Ala Arg Cys Phe Leu Ser Glu Leu Ile Lys Lys
  65                  70                  75                  80
 Pro Ser Gly Gly Ser Val Thr Leu Ser Glu Ser Thr Ala Ile Ile Ser
                  85                  90                  95    
 Tyr Gly Thr Thr Gly Leu Val Thr Trp Asp Ala Ala Leu Tyr Leu Ala
             100                 105                 110        
 Glu Trp Ala Ile Glu Asn Pro Ala Val Phe Thr Asn Arg Thr Val Leu
         115                 120                 125            
 Glu Leu Gly Ser Gly Ala Gly Leu Thr Gly Leu Ala Ile Cys Lys Met
     130                 135                 140                
 Cys Arg Pro Arg Ala Tyr Ile Phe Ser Asp Cys His Ser Arg Val Leu
 145                 150                 155                 160
 Glu Gln Leu Arg Gly Asn Val Leu Leu Asn Gly Leu Ser Leu Glu Ala
                 165                 170                 175    
 Asp Ile Thr Ala Asn Val Arg Gln Pro Gln Val Thr Val Ala Gln Leu
             180                 185                 190        
 Asp Trp Asp Val Ala Thr Val His Gln Leu Ser Ala Phe Gln Pro Asp
         195                 200                 205            
 Val Val Ile Ala Ala Asp Val Leu Tyr Cys Pro Glu Ala Ile Met Ser
     210                 215                 220                
 Leu Val Gly Val Leu Arg Arg Val Ala Ala Ala Gly Arg Thr Ser Gly
 225                 230                 235                 240
 Leu Leu Arg Ser Thr Trp Pro Leu Pro Ser Ala Thr Gln Arg Arg Ala
                 245                 250                 255    
 Ser Cys Ser Pro Pro Ser
             260        



      <210> 392
      <211> 558
      <212> PRT
      <213> Homo sapiens


      <400> 392
 Met Ser Asn Asp Gly Arg Ser Arg Asn Arg Asp Arg Arg Tyr Asp Glu
   1               5                  10                  15    
 Val Pro Ser Asp Leu Pro Tyr Gln Asp Thr Thr Ile Arg Thr His Pro
              20                  25                  30        
 Thr Leu His Asp Ser Glu Arg Ala Val Ser Ala Asp Pro Leu Pro Pro
          35                  40                  45            
 Pro Pro Leu Pro Leu Gln Pro Pro Phe Gly Pro Asp Phe Tyr Ser Ser
      50                  55                  60                
 Asp Thr Glu Glu Pro Ala Ile Ala Pro Asp Leu Lys Pro Val Arg Arg
  65                  70                  75                  80
 Phe Val Pro Asp Ser Trp Lys Asn Phe Phe Arg Gly Lys Lys Lys Asp
                  85                  90                  95    
 Pro Glu Trp Asp Lys Pro Val Ser Asp Ile Arg Tyr Ile Ser Asp Gly
             100                 105                 110        
 Val Glu Cys Ser Pro Pro Ala Ser Pro Ala Arg Pro Asn His Arg Ser
         115                 120                 125            
 Pro Leu Asn Ser Cys Lys Asp Pro Tyr Gly Gly Ser Glu Gly Thr Phe
     130                 135                 140                
 Ser Ser Arg Lys Glu Ala Asp Ala Val Phe Pro Arg Asp Pro Tyr Gly
 145                 150                 155                 160
 Ser Leu Asp Arg His Thr Gln Thr Val Arg Thr Tyr Ser Glu Lys Val
                 165                 170                 175    
 Glu Glu Tyr Asn Leu Arg Tyr Ser Tyr Met Lys Ser Trp Ala Gly Leu
             180                 185                 190        
 Leu Arg Ile Leu Gly Val Val Glu Leu Leu Leu Gly Ala Gly Val Phe
         195                 200                 205            
 Ala Cys Val Thr Ala Tyr Ile His Lys Asp Ser Glu Trp Tyr Asn Leu
     210                 215                 220                
 Phe Gly Tyr Ser Gln Pro Tyr Gly Met Gly Gly Val Gly Gly Leu Gly
 225                 230                 235                 240
 Ser Met Tyr Gly Gly Tyr Tyr Tyr Thr Gly Pro Lys Thr Pro Phe Val
                 245                 250                 255    
 Leu Val Val Ala Gly Leu Ala Trp Ile Thr Thr Ile Ile Ile Leu Val
             260                 265                 270        
 Leu Gly Met Ser Met Tyr Tyr Arg Thr Ile Leu Leu Asp Ser Asn Trp
         275                 280                 285            
 Trp Pro Leu Thr Glu Phe Gly Ile Asn Val Ala Leu Phe Ile Leu Tyr
     290                 295                 300                
 Met Ala Ala Ala Ile Val Tyr Val Asn Asp Thr Asn Arg Gly Gly Leu
 305                 310                 315                 320
 Cys Tyr Tyr Pro Leu Phe Asn Thr Pro Val Asn Ala Val Phe Cys Arg
                 325                 330                 335    
 Val Glu Gly Gly Gln Ile Ala Ala Met Ile Phe Leu Phe Val Thr Met
             340                 345                 350        
 Ile Val Tyr Leu Ile Ser Ala Leu Val Cys Leu Lys Leu Trp Arg His
         355                 360                 365            
 Glu Ala Ala Arg Arg His Arg Glu Tyr Met Glu Gln Gln Glu Ile Asn
     370                 375                 380                
 Glu Pro Ser Leu Ser Ser Lys Arg Lys Met Cys Glu Met Ala Thr Ser
 385                 390                 395                 400
 Gly Asp Arg Gln Arg Asp Ser Glu Val Asn Phe Lys Glu Leu Arg Thr
                 405                 410                 415    
 Ala Lys Met Lys Pro Glu Leu Leu Ser Gly His Ile Pro Pro Gly His
             420                 425                 430        
 Ile Pro Lys Pro Ile Val Met Pro Asp Tyr Val Ala Lys Tyr Pro Val
         435                 440                 445            
 Ile Gln Thr Asp Asp Glu Arg Glu Arg Tyr Lys Ala Val Phe Gln Asp
     450                 455                 460                
 Gln Phe Ser Glu Tyr Lys Glu Leu Ser Ala Glu Val Gln Ala Val Leu
 465                 470                 475                 480
 Arg Lys Phe Asp Glu Leu Asp Ala Val Met Ser Arg Leu Pro His His
                 485                 490                 495    
 Ser Glu Ser Arg Gln Glu His Glu Arg Ile Ser Arg Ile His Glu Glu
             500                 505                 510        
 Phe Lys Lys Lys Lys Asn Asp Pro Thr Phe Leu Glu Lys Lys Glu Arg
         515                 520                 525            
 Cys Asp Tyr Leu Lys Asn Lys Leu Ser His Ile Lys Gln Arg Ile Gln
     530                 535                 540                
 Glu Tyr Asp Lys Val Met Asn Trp Asp Val Gln Gly Tyr Ser
 545                 550                 555            



      <210> 393
      <211> 410
      <212> PRT
      <213> Homo sapiens


      <400> 393
 Met Gly Ala Gln Val Arg Leu Pro Pro Gly Glu Pro Cys Arg Glu Gly
   1               5                  10                  15    
 Tyr Val Leu Ser Leu Val Cys Pro Asn Ser Ser Gln Ala Trp Cys Glu
              20                  25                  30        
 Ile Thr Asn Val Ser Gln Leu Leu Ala Ser Pro Val Leu Tyr Thr Asp
          35                  40                  45            
 Leu Asn Tyr Ser Ile Asn Asn Leu Ser Ile Ser Ala Asn Val Glu Asn
      50                  55                  60                
 Lys Tyr Ser Leu Tyr Val Gly Leu Val Leu Ala Val Ser Ser Ser Ile
  65                  70                  75                  80
 Phe Ile Gly Ser Ser Phe Ile Leu Lys Lys Lys Gly Leu Leu Gln Leu
                  85                  90                  95    
 Ala Ser Lys Gly Phe Thr Arg Ala Gly Gln Gly Gly His Ser Tyr Leu
             100                 105                 110        
 Lys Glu Trp Leu Trp Trp Val Gly Leu Leu Ser Met Gly Ala Gly Glu
         115                 120                 125            
 Ala Ala Asn Phe Ala Ala Tyr Ala Phe Ala Pro Ala Thr Leu Val Thr
     130                 135                 140                
 Pro Leu Gly Ala Leu Ser Val Leu Ile Ser Ala Ile Leu Ser Ser Tyr
 145                 150                 155                 160
 Phe Leu Asn Glu His Leu Asn Ile His Gly Lys Ile Gly Cys Ile Leu
                 165                 170                 175    
 Ser Ile Leu Gly Ser Thr Val Met Val Ile His Ala Pro Gln Glu Glu
             180                 185                 190        
 Glu Val Thr Ser Leu His Glu Met Glu Met Lys Leu Arg Asp Pro Gly
         195                 200                 205            
 Phe Ile Ser Phe Ala Val Ile Ile Thr Val Ile Ser Leu Val Leu Ile
     210                 215                 220                
 Leu Ile Val Ala Pro Lys Lys Gly Gln Thr Asn Ile Leu Val Tyr Ile
 225                 230                 235                 240
 Ser Ile Cys Ser Leu Ile Gly Ala Phe Ser Val Ser Ser Val Lys Gly
                 245                 250                 255    
 Leu Gly Ile Ala Ile Lys Glu Leu Ile Glu Trp Lys Pro Val Tyr Lys
             260                 265                 270        
 His Pro Leu Val Phe Val Leu Leu Ala Val Leu Val Leu Ser Val Thr
         275                 280                 285            
 Thr Gln Ile Asn Tyr Leu Asn Lys Ala Leu Asp Thr Phe Asn Thr Ser
     290                 295                 300                
 Leu Val Thr Pro Ile Tyr Tyr Val Phe Phe Thr Ser Met Val Val Thr
 305                 310                 315                 320
 Cys Ser Ala Ile Leu Phe Gln Glu Trp Tyr Gly Met Thr Ala Gly Asp
                 325                 330                 335    
 Ile Ile Gly Thr Leu Ser Gly Phe Phe Thr Ile Ile Ile Gly Ile Phe
             340                 345                 350        
 Leu Leu His Ala Phe Lys Asn Thr Asp Ile Thr Trp Ser Glu Leu Thr
         355                 360                 365            
 Ser Thr Ala Lys Lys Glu Ala Val Ser Leu Asn Val Asn Glu Asn Asn
     370                 375                 380                
 Tyr Val Leu Leu Glu Asn Leu Glu Cys Ser Ala Pro Gly Tyr Asn Asp
 385                 390                 395                 400
 Asp Val Thr Leu Phe Ser Arg Thr Asp Asp
                 405                 410



      <210> 394
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 394
 Met Ala Asp Val Ile Asn Val Ser Val Asn Leu Glu Ala Phe Ser Gln
   1               5                  10                  15    
 Ala Ile Ser Ala Ile Gln Ala Leu Arg Ser Ser Val Ser Arg Leu Phe
              20                  25                  30        
 Asp Cys Leu Lys Asp Gly Met Arg Asn Lys Glu Thr Leu Glu Gly Arg
          35                  40                  45            
 Glu Lys Ala Phe Ile Ala His Phe Gln Asp Asn Leu His Ser Val Asn
      50                  55                  60                
 Arg Asp Leu Asn Glu Leu Glu Arg Leu Ser Asn Gln Met Gly Val Ser
  65                  70                  75                  80
 Ala Lys Arg Arg Pro Lys Ala Gln Pro Thr Thr Leu Val Leu Pro Pro
                  85                  90                  95    
 Gln Tyr Val Asp Asp Val Ile Ser Arg Ile Asp Arg Met Phe Pro Glu
             100                 105                 110        
 Met Ser Ile His Leu Ser Arg Pro Asn Gly Thr Ser Ala Met Leu Leu
         115                 120                 125            
 Val Thr Leu Gly Lys Val Leu Lys Val Ile Val Val Met Arg Ser Leu
     130                 135                 140                
 Phe Ile Asp Arg Thr Ile Val Lys Gly Tyr Asn Glu Asn Val Tyr Thr
 145                 150                 155                 160
 Glu Asp Gly Lys Leu Asp Ile Trp Ser Lys Ser Asn Tyr Gln Val Phe
                 165                 170                 175    
 Gln Lys Val Thr Asp His Ala Thr Thr Ala Leu Leu His Tyr Gln Leu
             180                 185                 190        
 Pro Gln Met Pro Asp Val Val Val Arg Ser Phe Met Thr Trp Leu Arg
         195                 200                 205            
 Ser Tyr Ile Lys Leu Phe Gln Ala Pro Cys Gln Arg Cys Gly Lys Phe
     210                 215                 220                
 Leu Gln Asp Gly Leu Pro Pro Thr Trp Arg Asp Phe Arg Thr Leu Glu
 225                 230                 235                 240
 Ala Phe His Asp Thr Cys Arg Gln
                 245            



      <210> 395
      <211> 967
      <212> PRT
      <213> Homo sapiens


      <400> 395
 Met Pro Trp Val Glu Pro Lys Pro Arg Pro Gly Pro Glu Gln Lys Pro
   1               5                  10                  15    
 Lys Leu Thr Lys Pro Asp Ser Ala Thr Gly Pro Gln Trp Tyr Gln Glu
              20                  25                  30        
 Ser Gln Glu Ser Glu Ser Glu Gly Lys Gln Pro Pro Pro Gly Pro Leu
          35                  40                  45            
 Ala Pro Pro Lys Ser Pro Glu Pro Ser Gly Pro Leu Ala Ser Glu Gln
      50                  55                  60                
 Asp Ala Pro Leu Pro Glu Gly Asp Asp Ala Pro Pro Arg Pro Ser Met
  65                  70                  75                  80
 Leu Asp Asp Ala Pro Arg Leu Pro Leu Glu Leu Asp Asp Ala Pro Leu
                  85                  90                  95    
 Pro Glu Glu Glu Thr Pro Glu Pro Thr Ala Ile Cys Arg His Arg His
             100                 105                 110        
 Arg Cys His Thr Asp Cys Leu Glu Gly Leu Leu Ser Arg Thr Phe Gln
         115                 120                 125            
 Trp Leu Gly Trp Gln Val Gly Ala His Pro Trp Ile Phe Leu Leu Ala
     130                 135                 140                
 Pro Leu Met Leu Thr Ala Ala Leu Gly Thr Gly Phe Leu Tyr Leu Pro
 145                 150                 155                 160
 Lys Asp Glu Glu Glu Asp Leu Glu Glu His Tyr Thr Pro Val Gly Ser
                 165                 170                 175    
 Pro Ala Lys Ala Glu Arg Arg Phe Val Gln Gly His Phe Thr Thr Asn
             180                 185                 190        
 Asp Ser Tyr Arg Phe Ser Ala Ser Arg Arg Ser Thr Glu Ala Asn Phe
         195                 200                 205            
 Val Ser Leu Leu Val Val Ser Tyr Ser Asp Ser Leu Leu Asp Pro Ala
     210                 215                 220                
 Thr Phe Ala Glu Val Ser Lys Leu Asp Gly Ala Val Gln Asp Leu Arg
 225                 230                 235                 240
 Val Ala Arg Glu Lys Gly Ser Gln Ile Gln Tyr Gln Gln Val Cys Ala
                 245                 250                 255    
 Arg Tyr Arg Ala Leu Cys Val Pro Pro Asn Pro Ile Leu Tyr Ala Trp
             260                 265                 270        
 Gln Val Asn Lys Thr Leu Asn Leu Ser Ser Ile Ser Phe Pro Ala Tyr
         275                 280                 285            
 Asn His Gly Arg His Pro Leu Tyr Leu Thr Gly Phe Phe Gly Gly Tyr
     290                 295                 300                
 Ile Leu Gly Gly Ser Leu Gly Met Gly Gln Leu Leu Leu Arg Ala Lys
 305                 310                 315                 320
 Ala Met Arg Leu Leu Tyr Tyr Leu Lys Thr Glu Asp Pro Glu Tyr Asp
                 325                 330                 335    
 Val Gln Ser Lys Gln Trp Leu Thr His Leu Leu Asp Gln Phe Thr Asn
             340                 345                 350        
 Ile Lys Asn Ile Leu Ala Leu Lys Lys Ile Glu Val Pro Gly Gly Val
         355                 360                 365            
 Gly Leu Gln Gly Gly Gln Glu Lys Val Val His Phe Thr Ser Leu Ser
     370                 375                 380                
 Arg Gln Leu Glu Phe Glu Ala Thr Ser Val Thr Val Ile Pro Val Phe
 385                 390                 395                 400
 His Leu Ala Tyr Ile Leu Ile Ile Leu Phe Ala Val Thr Ser Cys Phe
                 405                 410                 415    
 Arg Phe Asp Cys Ile Arg Asn Lys Met Cys Val Ala Ala Phe Gly Val
             420                 425                 430        
 Ile Ser Ala Phe Leu Ala Val Val Ser Gly Phe Gly Leu Leu Leu His
         435                 440                 445            
 Ile Gly Val Pro Phe Val Ile Ile Val Ala Asn Ser Pro Phe Leu Ile
     450                 455                 460                
 Leu Gly Val Gly Val Asp Asp Met Phe Ile Met Ile Ser Ala Trp His
 465                 470                 475                 480
 Lys Thr Asn Leu Ala Gly Asp Ile Arg Glu Arg Met Ser Asn Val Tyr
                 485                 490                 495    
 Ser Lys Ala Ala Val Ser Ile Thr Ile Thr Thr Ile Thr Asn Ile Leu
             500                 505                 510        
 Ala Leu Tyr Thr Gly Ile Met Ser Ser Phe Arg Ser Val Gln Cys Phe
         515                 520                 525            
 Cys Ile Tyr Thr Gly Thr Thr Leu Leu Phe Cys Tyr Phe Tyr Asn Ile
     530                 535                 540                
 Thr Cys Phe Gly Ala Phe Met Ala Leu Asp Gly Lys Arg Glu Val Val
 545                 550                 555                 560
 Cys Leu Cys Trp Leu Lys Lys Ala Asp Pro Lys Trp Pro Ser Phe Lys
                 565                 570                 575    
 Lys Phe Cys Cys Phe Pro Phe Gly Ser Val Pro Asp Glu His Gly Thr
             580                 585                 590        
 Asp Ile His Pro Met Ser Leu Phe Phe Arg Asp Tyr Phe Gly Pro Phe
         595                 600                 605            
 Leu Thr Arg Ser Glu Ser Lys Tyr Phe Val Val Phe Ile Tyr Val Leu
     610                 615                 620                
 Tyr Ile Ile Ser Ser Ile Tyr Gly Cys Phe His Val Gln Glu Gly Leu
 625                 630                 635                 640
 Asp Leu Arg Asn Leu Ala Ser Asp Asp Ser Tyr Ile Thr Pro Tyr Phe
                 645                 650                 655    
 Asn Val Glu Glu Asn Tyr Phe Ser Asp Tyr Gly Pro Arg Val Met Val
             660                 665                 670        
 Ile Val Thr Lys Lys Val Asp Tyr Trp Asp Lys Asp Val Arg Gln Lys
         675                 680                 685            
 Leu Glu Asn Cys Thr Lys Ile Phe Glu Lys Asn Val Tyr Val Asp Lys
     690                 695                 700                
 Asn Leu Thr Glu Phe Trp Leu Asp Ala Tyr Val Gln Tyr Leu Lys Gly
 705                 710                 715                 720
 Asn Ser Gln Asp Pro Asn Glu Lys Asn Thr Phe Met Asn Asn Ile Pro
                 725                 730                 735    
 Asp Phe Leu Ser Asn Phe Pro Asn Phe Gln His Asp Ile Asn Ile Ser
             740                 745                 750        
 Ser Ser Asn Glu Ile Ile Ser Ser Arg Gly Phe Ile Gln Thr Thr Asp
         755                 760                 765            
 Val Ser Ser Ser Ala Lys Lys Lys Ile Leu Leu Phe Gln Leu Arg Arg
     770                 775                 780                
 Ile Ala Glu Asp Cys Gln Ile Pro Leu Met Val Tyr Asn Gln Ala Phe
 785                 790                 795                 800
 Ile Tyr Phe Asp Gln Tyr Ala Ala Ile Leu Glu Asp Thr Val Arg Asn
                 805                 810                 815    
 Val Leu Val Ala Ser Ala Ala Met Phe Ile Val Ser Leu Leu Leu Ile
             820                 825                 830        
 Pro Tyr Pro Leu Cys Ser Leu Trp Val Thr Phe Ala Ile Gly Ser Val
         835                 840                 845            
 Ile Val Gly Val Thr Gly Phe Met Ala Phe Trp Lys Val Asn Leu Asp
     850                 855                 860                
 Ser Ile Ser Met Ile Asn Leu Val Ile Cys Ile Gly Phe Ser Phe Asp
 865                 870                 875                 880
 Phe Ser Ala His Ile Ser Tyr Ala Phe Val Ser Ser Ser Gln Pro Ser
                 885                 890                 895    
 Val Asn Gln Lys Ser Val Glu Ala Leu Tyr Leu Leu Gly Tyr Pro Val
             900                 905                 910        
 Leu Gln Ser Ala Ile Ser Thr Ile Ile Gly Val Cys Val Leu Ala Ala
         915                 920                 925            
 Ala Lys Ala Tyr Ile Phe Arg Thr Phe Phe Lys Ile Met Phe Leu Val
     930                 935                 940                
 Met Ile Phe Gly Ala Ala His Gly Leu Ile Phe Ile Pro Val Phe Leu
 945                 950                 955                 960
 Thr Phe Phe Gly Arg Phe Ile
                 965        



      <210> 396
      <211> 445
      <212> PRT
      <213> Homo sapiens


      <400> 396
 Met Val Asp Thr Glu Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala
   1               5                  10                  15    
 Gly Asp Leu Glu Ser Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly
              20                  25                  30        
 Asn Ile Gln Glu Ile Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser
          35                  40                  45            
 Phe Gly Phe Thr Glu Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp
      50                  55                  60                
 Gly Ser Val Ile Thr Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser
  65                  70                  75                  80
 Val Thr Tyr Pro Val Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly
                  85                  90                  95    
 Ala Leu Asn Ile Glu Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr
             100                 105                 110        
 His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg
         115                 120                 125            
 Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys
     130                 135                 140                
 Ile Gln Lys Lys Lys Lys Lys Lys Cys Gln Tyr Cys Arg Phe His Lys
 145                 150                 155                 160
 Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met
                 165                 170                 175    
 Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu
             180                 185                 190        
 His Asp Ile Glu Asp Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys
         195                 200                 205            
 Arg Ile Tyr Glu Ala Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys
     210                 215                 220                
 Ala Arg Val Ile Leu Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val
 225                 230                 235                 240
 Ile His Asp Met Glu Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala
                 245                 250                 255    
 Lys Leu Val Ala Asn Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile
             260                 265                 270        
 Phe His Cys Cys Gln Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr
         275                 280                 285            
 Glu Phe Ala Lys Ala Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp
     290                 295                 300                
 Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met
 305                 310                 315                 320
 Leu Ser Ser Val Met Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn
                 325                 330                 335    
 Gly Phe Ile Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys
             340                 345                 350        
 Asp Ile Met Glu Pro Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu
         355                 360                 365            
 Glu Leu Asp Asp Ser Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys
     370                 375                 380                
 Cys Gly Gly Gly His Gln Ser Asn His Pro Asp Asp Ile Phe Leu Phe
 385                 390                 395                 400
 Pro Lys Leu Leu Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu
                 405                 410                 415    
 His Ala Gln Leu Val Gln Ile Ile Lys Lys Thr Glu Ser Asp Ala Ala
             420                 425                 430        
 Leu His Pro Leu Leu Gln Glu Ile Tyr Arg Asp Met Tyr
         435                 440                 445



      <210> 397
      <211> 418
      <212> PRT
      <213> Homo sapiens


      <400> 397
 Met Pro Phe Ala Trp Lys Phe Lys Ala Phe Leu Asp Glu Ala Gln Lys
   1               5                  10                  15    
 Ile Lys Gly Leu Val Ile Glu Tyr Phe Glu Ser Gln Ile Ser Gln Val
              20                  25                  30        
 Cys Met Trp Phe Phe Ser Lys Tyr Ala Gln Glu Trp Asn Ile Ser Phe
          35                  40                  45            
 Tyr Glu Cys Glu Met Phe Glu Ile Gln Ile Cys Gln Glu Leu Pro Pro
      50                  55                  60                
 His Trp Val Gln Gly Ser Gly Gly Leu Val Leu Pro Lys Val Ser Pro
  65                  70                  75                  80
 Leu Tyr Pro Ala Asn Ser Gly Lys Phe Thr Arg Phe Arg Tyr Lys Pro
                  85                  90                  95    
 Ala Ala Leu Gly Leu Glu Pro Pro Leu Pro Pro Arg Ser Phe Pro Asn
             100                 105                 110        
 Leu Phe Ser Arg Pro Glu Pro Leu Pro Glu Pro Gly Arg Arg Gly Cys
         115                 120                 125            
 Asn Arg Ser Arg Glu Pro Ala Ala Arg Ala Pro Ser Pro Pro Pro Pro
     130                 135                 140                
 Phe Glu Gly Ala Pro Gly Arg Ala Met Val Lys Val Thr Phe Asn Ser
 145                 150                 155                 160
 Ala Leu Ala Gln Lys Glu Ala Lys Lys Asp Glu Pro Lys Ser Gly Glu
                 165                 170                 175    
 Glu Ala Leu Ile Ile Pro Pro Asp Ala Val Ala Val Asp Cys Lys Asp
             180                 185                 190        
 Pro Asp Asp Val Val Pro Val Gly Gln Arg Arg Ala Trp Cys Trp Cys
         195                 200                 205            
 Met Cys Phe Gly Leu Ala Phe Met Leu Ala Gly Val Ile Leu Gly Gly
     210                 215                 220                
 Ala Tyr Leu Tyr Lys Tyr Phe Ala Leu Gln Pro Asp Asp Val Tyr Tyr
 225                 230                 235                 240
 Cys Gly Ile Lys Tyr Ile Lys Asp Asp Val Ile Leu Asn Glu Pro Ser
                 245                 250                 255    
 Ala Asp Ala Pro Ala Ala Leu Tyr Gln Thr Ile Glu Glu Asn Ile Lys
             260                 265                 270        
 Ile Phe Glu Glu Glu Glu Val Glu Phe Ile Ser Val Pro Val Pro Glu
         275                 280                 285            
 Phe Ala Asp Ser Asp Pro Ala Asn Ile Val His Asp Phe Asn Lys Lys
     290                 295                 300                
 Leu Thr Ala Tyr Leu Asp Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro
 305                 310                 315                 320
 Leu Asn Thr Ser Ile Val Met Pro Pro Arg Asn Leu Leu Glu Leu Leu
                 325                 330                 335    
 Ile Asn Ile Lys Ala Gly Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His
             340                 345                 350        
 Glu His Met Val Ile Thr Asp Arg Ile Glu Asn Ile Asp His Leu Gly
         355                 360                 365            
 Phe Phe Ile Tyr Arg Leu Cys His Asp Lys Glu Thr Tyr Lys Leu Gln
     370                 375                 380                
 Arg Arg Glu Thr Ile Lys Gly Ile Gln Lys Arg Glu Ala Ser Asn Cys
 385                 390                 395                 400
 Phe Ala Ile Arg His Phe Glu Asn Lys Phe Ala Val Glu Thr Leu Ile
                 405                 410                 415    
 Cys Ser
        



      <210> 398
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 398
 Met Gly Glu Lys Met Ala Glu Glu Glu Arg Phe Pro Asn Thr Thr His
   1               5                  10                  15    
 Glu Gly Phe Asn Val Thr Leu His Thr Thr Leu Val Val Thr Thr Lys
              20                  25                  30        
 Leu Val Leu Pro Thr Pro Gly Lys Pro Ile Leu Pro Val Gln Thr Gly
          35                  40                  45            
 Glu Gln Ala Gln Gln Glu Glu Gln Ser Ser Gly Met Thr Ile Phe Phe
      50                  55                  60                
 Ser Leu Leu Val Leu Ala Ile Cys Ile Ile Leu Val His Leu Leu Ile
  65                  70                  75                  80
 Arg Tyr Arg Leu His Phe Leu Pro Glu Ser Val Ala Val Val Ser Leu
                  85                  90                  95    
 Gly Ile Leu Met Gly Ala Val Ile Lys Ile Ile Glu Phe Lys Lys Leu
             100                 105                 110        
 Ala Asn Trp Lys Glu Glu Glu Met Phe Arg Pro Asn Met Phe Phe Leu
         115                 120                 125            
 Leu Leu Leu Pro Pro Ile Ile Phe Glu Ser Gly Tyr Ser Leu His Lys
     130                 135                 140                
 Gly Asn Phe Phe Gln Asn Ile Gly Ser Ile Thr Leu Phe Ala Val Phe
 145                 150                 155                 160
 Gly Thr Ala Ile Ser Ala Phe Val Val Gly Gly Gly Ile Tyr Phe Leu
                 165                 170                 175    
 Gly Gln Ala Asp Val Ile Ser Lys Leu Asn Met Thr Asp Ser Phe Ala
             180                 185                 190        
 Phe Gly Ser Leu Ile Ser Ala Val Asp Pro Val Ala Thr Ile Ala Ile
         195                 200                 205            
 Phe Asn Ala Leu His Val Asp Pro Val Leu Asn Met Leu Val Phe Gly
     210                 215                 220                
 Glu Ser Ile Leu Asn Asp Ala Val Ser Ile Val Leu Thr Asn Thr Ala
 225                 230                 235                 240
 Glu Gly Leu Thr Arg Lys Asn Met Ser Asp Val Ser Gly Trp Gln Thr
                 245                 250                 255    
 Phe Leu Gln Ala Leu Asp Tyr Phe Leu Lys Met Phe Phe Gly Ser Ala
             260                 265                 270        
 Ala Leu Gly Thr Leu Thr Gly Leu Ile Ser Ala Leu Val Leu Lys His
         275                 280                 285            
 Ile Asp Leu Arg Lys Thr Pro Ser Leu Glu Phe Gly Met Met Ile Ile
     290                 295                 300                
 Phe Ala Tyr Leu Pro Tyr Gly Leu Ala Glu Gly Ile Ser Leu Ser Gly
 305                 310                 315                 320
 Ile Met Ala Ile Leu Phe Ser Gly Ile Val Met Ser His Tyr Thr His
                 325                 330                 335    
 His Asn Leu Ser Pro Val Thr Gln Ile Leu Met Gln Gln Thr Leu Arg
             340                 345                 350        
 Thr Val Ala Phe Leu Cys Glu Thr Cys Val Phe Ala Phe Leu Gly Leu
         355                 360                 365            
 Ser Ile Phe Ser Phe Pro His Lys Phe Glu Ile Ser Phe Val Ile Trp
     370                 375                 380                
 Cys Ile Val Leu Val Leu Phe Gly Arg Ala Val Asn Ile Phe Pro Leu
 385                 390                 395                 400
 Ser Tyr Leu Leu Asn Phe Phe Arg Asp His Lys Ile Thr Pro Lys Met
                 405                 410                 415    
 Met Phe Ile Met Trp Phe Ser Gly Leu Arg Gly Ala Ile Pro Tyr Ala
             420                 425                 430        
 Leu Ser Leu His Leu Asp Leu Glu Pro Met Glu Lys Arg Gln Leu Ile
         435                 440                 445            
 Gly Thr Thr Thr Ile Val Ile Val Leu Phe Thr Ile Leu Leu Leu Gly
     450                 455                 460                
 Gly Ser Thr Met Pro Leu Ile Arg Leu Met Asp Ile Glu Asp Ala Lys
 465                 470                 475                 480
 Ala His Arg Arg Asn Lys Lys Asp Val Asn Leu Ser Lys Thr Glu Lys
                 485                 490                 495    
 Met Gly Asn Thr Val Glu Ser Glu His Leu Ser Glu Leu Thr Glu Glu
             500                 505                 510        
 Glu Tyr Glu Ala His Tyr Ile Arg Arg Gln Asp Leu Lys Gly Phe Val
         515                 520                 525            
 Trp Leu Asp Ala Lys Tyr Leu Asn Pro Phe Phe Thr Arg Arg Leu Thr
     530                 535                 540                
 Gln Glu Asp Leu His His Gly Arg Ile Gln Met Lys Thr Leu Thr Asn
 545                 550                 555                 560
 Lys Trp Tyr Glu Glu Val Arg Gln Gly Pro Ser Gly Ser Glu Asp Asp
                 565                 570                 575    
 Glu Gln Glu Leu Leu
             580    



      <210> 399
      <211> 310
      <212> PRT
      <213> Homo sapiens


      <400> 399
 Met Ala Met Asn Tyr Asn Ala Lys Asp Glu Val Asp Gly Gly Pro Pro
   1               5                  10                  15    
 Cys Ala Pro Gly Gly Thr Ala Lys Thr Arg Arg Pro Asp Asn Thr Ala
              20                  25                  30        
 Phe Lys Gln Gln Arg Leu Pro Ala Trp Gln Pro Ile Leu Thr Ala Gly
          35                  40                  45            
 Thr Val Leu Pro Ile Phe Phe Ile Ile Gly Leu Ile Phe Ile Pro Ile
      50                  55                  60                
 Gly Ile Gly Ile Phe Val Thr Ser Asn Asn Ile Arg Glu Ile Glu Ile
  65                  70                  75                  80
 Asp Tyr Thr Gly Thr Glu Pro Ser Ser Pro Cys Asn Lys Cys Leu Ser
                  85                  90                  95    
 Pro Asp Val Thr Pro Cys Phe Cys Thr Ile Asn Phe Thr Leu Glu Lys
             100                 105                 110        
 Ser Phe Glu Gly Asn Val Phe Met Tyr Tyr Gly Leu Ser Asn Phe Tyr
         115                 120                 125            
 Gln Asn His Arg Arg Tyr Val Lys Ser Arg Asp Asp Ser Gln Leu Asn
     130                 135                 140                
 Gly Asp Ser Ser Ala Leu Leu Asn Pro Ser Lys Glu Cys Glu Pro Tyr
 145                 150                 155                 160
 Arg Arg Asn Glu Asp Lys Pro Ile Ala Pro Cys Gly Ala Ile Ala Asn
                 165                 170                 175    
 Ser Met Phe Asn Asp Thr Leu Glu Leu Phe Leu Ile Gly Asn Asp Ser
             180                 185                 190        
 Tyr Pro Ile Pro Ile Ala Leu Lys Lys Lys Gly Ile Ala Trp Trp Thr
         195                 200                 205            
 Asp Lys Asn Val Lys Phe Arg Asn Pro Pro Gly Gly Asp Asn Leu Glu
     210                 215                 220                
 Glu Arg Phe Lys Gly Thr Thr Lys Pro Val Asn Trp Leu Lys Pro Val
 225                 230                 235                 240
 Tyr Met Leu Asp Ser Asp Pro Asp Asn Asn Gly Phe Ile Asn Glu Asp
                 245                 250                 255    
 Phe Ile Val Trp Met Arg Thr Ala Ala Leu Pro Thr Phe Arg Lys Leu
             260                 265                 270        
 Tyr Arg Leu Ile Glu Arg Lys Ser Asp Leu His Pro Thr Leu Pro Ala
         275                 280                 285            
 Gly Arg Tyr Ser Leu Asn Val Thr Tyr Ser Ile Leu Phe Trp Leu Gly
     290                 295                 300                
 Ile Gln Ile His Arg Ala
 305                 310



      <210> 400
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 400
 Met Ile His Leu Arg Ile Ile Gln Arg Cys Tyr Met Ala Gly Leu Glu
   1               5                  10                  15    
 Asn Lys Lys Asn Val Val Phe Glu Ala Lys Gln Ile Cys Ile Gly Ile
              20                  25                  30        
 Leu Val Leu Pro Phe Ile Arg Cys Cys Cys Leu Val Gln Ile Thr Phe
          35                  40                  45            
 Ser Leu Ser Leu His Phe Leu Ile Tyr Asn Met Arg Arg Ile Ile Leu
      50                  55                  60                
 Ile Phe Val Val Val Val
  65                  70



      <210> 401
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 401
 Met Gln Ala Glu Glu Thr Lys Gly Ile Gly Ile Thr Ser Met Ala Lys
   1               5                  10                  15    
 Cys Leu Val Lys Ile Gln Thr Arg Arg Ser Leu Gln Leu His Met Val
              20                  25                  30        
 Asn His Cys Asn Ser Asn Val Phe Val Arg Leu Leu Arg Leu Gly Ser
          35                  40                  45            
 Lys Val Thr Ala Arg Asn Thr Gly Val Pro Leu Pro Lys Glu Glu Asn
      50                  55                  60                
 Ile Ser Ala Pro Leu Ile Ser Ser Ser Pro Val Lys Ala Ala Arg Glu
  65                  70                  75                  80
 Tyr Glu Asp Pro Pro Ser Glu Glu Glu Asp Lys Ile Lys Glu Glu Pro
                  85                  90                  95    
 Leu Thr Ile Ser Glu Leu Val Tyr Asn Pro Ser Ala Ser Leu Leu Pro
             100                 105                 110        
 Thr Pro Val Asp Asp Asp Glu Ile Asp Met Leu Phe Asp Cys Pro Ser
         115                 120                 125            
 Arg Leu Glu Leu Glu Arg Glu Asp Thr Asp Ser Phe Glu Asp Leu Glu
     130                 135                 140                
 Ala Asp Glu Asn Ala Phe Leu Ile Ala Glu Glu Glu Glu Leu Lys Glu
 145                 150                 155                 160
 Ala Arg Arg Ala Leu Ser Trp Ser Tyr Asp Ile Leu Thr Gly His Ile
                 165                 170                 175    
 Arg Val Asn Pro Leu Val Lys Ser Phe Ser Arg Leu Leu Val Val Gly
             180                 185                 190        
 Leu Gly Leu Leu Leu Phe Val Phe Pro Leu Leu Leu Leu Leu Leu Glu
         195                 200                 205            
 Ser Gly Ile Asp Leu Ser Phe Leu Cys Glu Ile Arg Gln Thr Pro Glu
     210                 215                 220                
 Phe Glu Gln Phe His Tyr Glu Tyr Tyr Cys Pro Leu Lys Glu Trp Val
 225                 230                 235                 240
 Ala Gly Lys Val His Leu Ile Leu Tyr Met Leu Gly Cys Ser
                 245                 250                



      <210> 402
      <211> 497
      <212> PRT
      <213> Homo sapiens


      <400> 402
 Met Ala Leu Cys Gly Gln Ala Ala Gly Ala Ala Ser Leu Pro Ser Glu
   1               5                  10                  15    
 Leu Ile Val His Ile Phe Ser Phe Leu Pro Ala Pro Asp Arg Leu Arg
              20                  25                  30        
 Ala Ser Ala Ser Cys Ser His Trp Arg Glu Cys Leu Phe Tyr Pro Ala
          35                  40                  45            
 Leu Trp Pro Gln Leu Arg Ile Cys Leu Arg Val Ser Pro Ala Glu Gln
      50                  55                  60                
 Pro Arg Leu Glu Phe Leu Met Arg Lys Cys Gly Trp Phe Val Arg Glu
  65                  70                  75                  80
 Leu Arg Val Glu Phe Ala Ala Glu Asn Tyr Leu Ser Gly Gly Gly Pro
                  85                  90                  95    
 Gly Asp Gly Gly Gly Ala Asp Thr Gly Thr Gly Gly Glu Glu Val Glu
             100                 105                 110        
 Ala Leu Gln Leu Ser Ala Arg Trp Leu Glu Val Leu Arg Thr Tyr Leu
         115                 120                 125            
 Glu Leu Val Leu Cys Val Leu Val Ser Ile Arg Asn Asn Arg Asn Leu
     130                 135                 140                
 Gln Lys Phe Ser Leu Phe Gly Asp Ile Ser Val Leu Gln Gln Gln Gly
 145                 150                 155                 160
 Ser Leu Ser Asn Thr Tyr Leu Ser Lys Val Asp Pro Asp Gly Lys Lys
                 165                 170                 175    
 Ile Lys Gln Ile Gln Gln Leu Phe Glu Glu Ile Leu Ser Asn Ser Arg
             180                 185                 190        
 Gln Leu Lys Trp Leu Ser Cys Gly Phe Met Leu Glu Ile Val Thr Pro
         195                 200                 205            
 Thr Ser Leu Ser Ser Leu Ser Asn Ala Val Ala Asn Thr Met Glu His
     210                 215                 220                
 Leu Ser Leu Leu Asp Asn Asn Ile Pro Gly Asn Ser Thr Leu Ile Thr
 225                 230                 235                 240
 Ala Val Glu Leu Glu Arg Phe Val Asn Leu His Ser Leu Ala Leu Asp
                 245                 250                 255    
 Phe Cys Asp Phe Thr Ala Glu Met Ala Arg Val Leu Thr Asp Ser Asn
             260                 265                 270        
 His Val Pro Leu Gln Arg Leu Ser Leu Leu Val His Asn Val Ser Val
         275                 280                 285            
 Met His Lys Ser Leu Asp Asn Met Pro Asn Asp Glu His Trp Lys Ala
     290                 295                 300                
 Leu Ser Arg Lys Ser Thr Ser Phe Arg Val Tyr Ile Met Ala Phe Asp
 305                 310                 315                 320
 Ile Lys Ser Glu Asp Met Leu Lys Ile Leu Lys Pro Ser Ile Pro Leu
                 325                 330                 335    
 Glu Arg Ile His Phe Asp Ser Tyr Ile Thr Cys Val Ser Gly Ala Ile
             340                 345                 350        
 Val Asp Leu Ile Ser Arg Gln Tyr Asp Lys Phe Leu Thr His Phe Ile
         355                 360                 365            
 Leu Met Asn Asp Val Ile Asp Thr Ser Gly Phe Pro Asp Leu Ser Asp
     370                 375                 380                
 Asn Arg Asn Glu Asp Pro Leu Val Leu Leu Ala Trp Arg Cys Thr Lys
 385                 390                 395                 400
 Leu Ser Leu Leu Ala Ile His Gly Tyr Thr Val Trp Ala His Asn Leu
                 405                 410                 415    
 Ile Ala Ile Ala Arg Leu Arg Gly Ser Asp Leu Lys Val Leu Glu Val
             420                 425                 430        
 Thr Glu Glu Ser Ile Asp Phe Asp Gln Gly Glu Leu Ala Asp Gln Asp
         435                 440                 445            
 Val Asp Pro Val His Asn Leu Ile Glu Gln Val Ser Leu Gly Leu Gly
     450                 455                 460                
 Gln Pro Trp His Ala Val Met Asp Ile Glu Ser Leu Ser Val Phe Thr
 465                 470                 475                 480
 Glu Pro Asn Arg His Phe Tyr Arg Glu Met Gln Ser Phe Ser Glu Asp
                 485                 490                 495    
 Ile
    



      <210> 403
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 403
 Met Ser Ser Cys Ser Asn Val Cys Gly Ser Arg Gln Ala Gln Ala Ala
   1               5                  10                  15    
 Ala Glu Gly Gly Tyr Gln Arg Tyr Gly Val Arg Ser Tyr Leu His Gln
              20                  25                  30        
 Phe Tyr Glu Asp Cys Thr Ala Ser Ile Trp Glu Tyr Glu Asp Asp Phe
          35                  40                  45            
 Gln Ile Gln Arg Ser Pro Asn Arg Trp Ser Ser Val Phe Trp Lys Val
      50                  55                  60                
 Gly Leu Ile Ser Gly Thr Val Phe Val Ile Leu Gly Leu Thr Val Leu
  65                  70                  75                  80
 Ala Val Gly Phe Leu Val Pro Pro Lys Ile Glu Ala Phe Gly Glu Ala
                  85                  90                  95    
 Asp Phe Val Val Val Asp Thr His Ala Val Gln Phe Asn Ser Ala Leu
             100                 105                 110        
 Asp Met Tyr Lys Leu Ala Gly Ala Val Leu Phe Cys Ile Gly Gly Thr
         115                 120                 125            
 Ser Met Ala Gly Cys Leu Leu Met Ser Val Phe Val Lys Ser Tyr Ser
     130                 135                 140                
 Lys Glu Glu Lys Phe Leu Gln Gln Lys Phe Lys Glu Arg Ile Ala Asp
 145                 150                 155                 160
 Ile Lys Ala His Thr Gln Pro Val Thr Lys Ala Pro Gly Pro Gly Glu
                 165                 170                 175    
 Thr Lys Ile Pro Val Thr Leu Ser Arg Val Gln Asn Val Gln Pro Leu
             180                 185                 190        
 Leu Ala Thr
         195



      <210> 404
      <211> 715
      <212> PRT
      <213> Homo sapiens


      <400> 404
 Met Ser Ala Lys Glu Arg Pro Lys Gly Lys Val Ile Lys Asp Ser Val
   1               5                  10                  15    
 Thr Leu Leu Pro Cys Phe Tyr Phe Val Glu Leu Pro Ile Leu Ala Ser
              20                  25                  30        
 Ser Val Val Ser Leu Tyr Phe Leu Glu Leu Thr Asp Val Phe Lys Pro
          35                  40                  45            
 Val His Ser Gly Phe Ser Cys Tyr Asp Arg Ser Leu Ser Met Pro Tyr
      50                  55                  60                
 Ile Glu Pro Thr Gln Glu Ala Ile Pro Phe Leu Met Leu Leu Ser Leu
  65                  70                  75                  80
 Ala Phe Ala Gly Pro Ala Ile Thr Ile Met Val Gly Glu Gly Ile Leu
                  85                  90                  95    
 Tyr Cys Cys Leu Ser Lys Arg Arg Asn Gly Val Gly Leu Glu Pro Asn
             100                 105                 110        
 Ile Asn Ala Gly Gly Cys Asn Phe Asn Ser Phe Leu Arg Arg Ala Val
         115                 120                 125            
 Arg Phe Val Gly Val His Val Phe Gly Leu Cys Ser Thr Ala Leu Ile
     130                 135                 140                
 Thr Asp Ile Ile Gln Leu Ser Thr Gly Tyr Gln Ala Pro Tyr Phe Leu
 145                 150                 155                 160
 Thr Val Cys Lys Pro Asn Tyr Thr Ser Leu Asn Val Ser Cys Lys Glu
                 165                 170                 175    
 Asn Ser Tyr Ile Val Glu Asp Ile Cys Ser Gly Ser Asp Leu Thr Val
             180                 185                 190        
 Ile Asn Ser Gly Arg Lys Ser Phe Pro Ser Gln His Ala Thr Leu Ala
         195                 200                 205            
 Ala Phe Ala Ala Val Tyr Val Ser Met Tyr Phe Asn Ser Thr Leu Thr
     210                 215                 220                
 Asp Ser Ser Lys Leu Leu Lys Pro Leu Leu Val Phe Thr Phe Ile Ile
 225                 230                 235                 240
 Cys Gly Ile Ile Cys Gly Leu Thr Arg Ile Thr Gln Tyr Lys Asn His
                 245                 250                 255    
 Pro Val Asp Val Tyr Cys Gly Phe Leu Ile Gly Gly Gly Ile Ala Leu
             260                 265                 270        
 Tyr Leu Gly Leu Tyr Ala Val Gly Asn Phe Leu Pro Ser Asp Glu Ser
         275                 280                 285            
 Met Phe Gln His Arg Asp Ala Leu Arg Ser Leu Thr Asp Leu Asn Gln
     290                 295                 300                
 Asp Pro Asn Arg Leu Leu Ser Ala Lys Asn Gly Ser Ser Ser Asp Gly
 305                 310                 315                 320
 Ile Ala His Thr Glu Gly Ile Leu Asn Arg Asn His Arg Asp Ala Ser
                 325                 330                 335    
 Ser Leu Thr Asn Leu Lys Arg Ala Asn Ala Asp Val Glu Ile Ile Thr
             340                 345                 350        
 Pro Arg Ser Pro Met Gly Lys Glu Asn Met Val Thr Phe Ser Asn Thr
         355                 360                 365            
 Leu Pro Arg Ala Asn Thr Pro Ser Val Glu Asp Pro Val Arg Arg Asn
     370                 375                 380                
 Ala Ser Ile His Ala Ser Met Asp Ser Ala Arg Ser Lys Gln Leu Leu
 385                 390                 395                 400
 Thr Gln Trp Lys Asn Lys Asn Glu Ser Arg Lys Leu Ser Leu Gln Val
                 405                 410                 415    
 Ile Glu Pro Glu Pro Gly Gln Ser Pro Pro Arg Ser Ile Glu Met Arg
             420                 425                 430        
 Ser Ser Ser Glu Pro Ser Arg Val Gly Val Asn Gly Asp His His Gly
         435                 440                 445            
 Pro Gly Asn Gln Tyr Leu Lys Ile Gln Pro Gly Ala Val Pro Gly Cys
     450                 455                 460                
 Asn Asn Ser Met Pro Gly Gly Pro Arg Val Ser Ile Gln Ser Arg Pro
 465                 470                 475                 480
 Gly Ser Ser Gln Leu Val His Ile Pro Glu Glu Thr Gln Glu Asn Ile
                 485                 490                 495    
 Ser Thr Ser Pro Lys Ser Ser Ser Ala Arg Ala Lys Trp Leu Lys Ala
             500                 505                 510        
 Ala Glu Lys Thr Val Ala Cys Asn Arg Ser Asn Ser Gln Pro Arg Ile
         515                 520                 525            
 Met Gln Val Ile Ala Met Ser Lys Gln Gln Gly Val Leu Gln Ser Ser
     530                 535                 540                
 Pro Lys Asn Thr Glu Gly Ser Thr Val Ser Cys Thr Gly Ser Ile Arg
 545                 550                 555                 560
 Tyr Lys Thr Leu Thr Asp His Glu Pro Ser Gly Ile Val Arg Val Glu
                 565                 570                 575    
 Ala His Pro Glu Asn Asn Arg Pro Ile Ile Gln Ile Pro Ser Thr Glu
             580                 585                 590        
 Gly Glu Gly Ser Gly Ser Trp Lys Trp Lys Ala Pro Glu Lys Gly Ser
         595                 600                 605            
 Leu Arg Gln Thr Tyr Glu Leu Asn Asp Leu Asn Arg Asp Ser Glu Ser
     610                 615                 620                
 Cys Glu Ser Leu Lys Asp Ser Phe Gly Ser Gly Asp Arg Lys Arg Ser
 625                 630                 635                 640
 Asn Ile Asp Ser Asn Glu His His His His Gly Ile Thr Thr Ile Arg
                 645                 650                 655    
 Val Thr Pro Val Glu Gly Ser Glu Ile Gly Ser Glu Thr Leu Ser Ile
             660                 665                 670        
 Ser Ser Ser Arg Asp Ser Thr Leu Arg Arg Lys Gly Asn Ile Ile Leu
         675                 680                 685            
 Ile Pro Glu Arg Ser Asn Ser Pro Glu Asn Thr Arg Asn Ile Phe Tyr
     690                 695                 700                
 Lys Gly Thr Ser Pro Thr Arg Ala Tyr Lys Asp
 705                 710                 715



      <210> 405
      <211> 331
      <212> PRT
      <213> Homo sapiens


      <400> 405
 Met Phe Lys Gly Leu Arg Glu Ser Val Phe Ala Phe Cys Ser Arg Val
   1               5                  10                  15    
 Met Arg Lys Cys Met Trp Leu Cys Val Gln Asp Ser Asn Val Phe Val
              20                  25                  30        
 Ser Gln Pro Ser Ser Val Leu Thr Gln Ala Pro Gly Ser Arg Ser Arg
          35                  40                  45            
 Ser Arg Ser Val Asp Ala Leu His Ala Ser Lys Arg Arg Ala Trp Gly
      50                  55                  60                
 Ile Val Ala Gly Leu Pro Gly Arg Gly Arg Val Leu Ala Ala Ala Ala
  65                  70                  75                  80
 Arg Ser Arg Val Pro Ala Ala Ala Ala Ala Ala Met Val Ser Pro Val
                  85                  90                  95    
 Thr Val Val Lys Ser Glu Gly Pro Lys Leu Val Pro Phe Phe Lys Ala
             100                 105                 110        
 Thr Cys Val Tyr Phe Val Leu Trp Leu Pro Ser Ser Ser Pro Ser Trp
         115                 120                 125            
 Val Ser Thr Leu Ile Lys Cys Leu Pro Ile Phe Cys Leu Trp Leu Phe
     130                 135                 140                
 Leu Leu Ala His Gly Leu Gly Phe Leu Leu Ala His Pro Ser Ala Thr
 145                 150                 155                 160
 Arg Ile Phe Val Gly Leu Val Phe Ser Ala Val Gly Asp Ala Phe Leu
                 165                 170                 175    
 Ile Trp Gln Asp Gln Gly Tyr Phe Val His Gly Leu Leu Met Phe Ala
             180                 185                 190        
 Val Thr His Met Phe Tyr Ala Ser Ala Phe Gly Met Gln Pro Leu Ala
         195                 200                 205            
 Leu Arg Thr Gly Leu Val Met Ala Ala Leu Ser Gly Leu Cys Tyr Ala
     210                 215                 220                
 Leu Leu Tyr Pro Cys Leu Ser Gly Ala Phe Thr Tyr Leu Val Gly Val
 225                 230                 235                 240
 Tyr Val Ala Leu Ile Gly Phe Met Gly Trp Arg Ala Met Ala Gly Leu
                 245                 250                 255    
 Arg Leu Ala Gly Ala Asp Trp Arg Trp Thr Glu Leu Ala Ala Gly Ser
             260                 265                 270        
 Gly Ala Leu Phe Phe Ile Ile Ser Asp Leu Thr Ile Ala Leu Asn Lys
         275                 280                 285            
 Phe Cys Phe Pro Val Pro Tyr Ser Arg Ala Leu Ile Met Ser Thr Tyr
     290                 295                 300                
 Tyr Val Ala Gln Met Leu Val Ala Leu Ser Ala Val Glu Ser Arg Glu
 305                 310                 315                 320
 Pro Val Glu His Tyr Arg Leu Thr Lys Ala Asn
                 325                 330    



      <210> 406
      <211> 783
      <212> PRT
      <213> Homo sapiens


      <400> 406
 Met Leu Asp Gln His His Thr Asp Leu Ile Leu Lys Leu His Ala Ala
   1               5                  10                  15    
 Val Thr Lys Ile Gln Val Pro Arg Pro Gly Phe Asn Tyr Thr Phe Ala
              20                  25                  30        
 His Ile Cys Ile Leu Asn Asn Asp Lys Thr Cys Ile Ala Asp Asp Ile
          35                  40                  45            
 Val His Val Leu Glu Glu Leu Lys Asn Ala Arg Ala Thr Asn Arg Thr
      50                  55                  60                
 Asn Phe Ala Ile Thr Tyr Pro Ile Thr His Leu Lys Asp Gly Arg Ala
  65                  70                  75                  80
 Val Tyr Asn Gly His Gln Leu Gly Gly Val Thr Val His Ser Lys Asp
                  85                  90                  95    
 Arg Val Lys Ser Ala Glu Ala Ile Gln Leu Thr Tyr Tyr Leu Gln Ser
             100                 105                 110        
 Ile Asn Ser Leu Asn Asp Met Val Ala Glu Arg Trp Glu Ser Ser Phe
         115                 120                 125            
 Cys Asp Thr Val Arg Leu Phe Gln Lys Ser Asn Ser Lys Val Lys Met
     130                 135                 140                
 Tyr Pro Tyr Thr Ser Ser Ser Leu Arg Glu Asp Phe Gln Lys Thr Ser
 145                 150                 155                 160
 Arg Val Ser Glu Arg Tyr Leu Val Thr Ser Leu Ile Leu Val Val Thr
                 165                 170                 175    
 Met Ala Ile Leu Cys Cys Ser Met Gln Asp Cys Val Arg Ser Lys Pro
             180                 185                 190        
 Trp Leu Gly Leu Leu Gly Leu Val Thr Ile Ser Leu Ala Thr Leu Thr
         195                 200                 205            
 Ala Ala Gly Ile Ile Asn Leu Thr Gly Gly Lys Tyr Asn Ser Thr Phe
     210                 215                 220                
 Leu Gly Val Pro Phe Val Met Leu Gly His Gly Leu Tyr Gly Thr Phe
 225                 230                 235                 240
 Glu Met Leu Ser Ser Trp Arg Lys Thr Arg Glu Asp Gln His Val Lys
                 245                 250                 255    
 Glu Arg Thr Ala Ala Val Tyr Ala Asp Ser Met Leu Ser Phe Ser Leu
             260                 265                 270        
 Thr Thr Ala Met Tyr Leu Val Thr Phe Gly Ile Gly Ala Ser Pro Phe
         275                 280                 285            
 Thr Asn Ile Glu Ala Ala Arg Ile Phe Cys Cys Asn Ser Cys Ile Ala
     290                 295                 300                
 Ile Phe Phe Asn Tyr Leu Tyr Val Leu Ser Phe Tyr Gly Ser Ser Leu
 305                 310                 315                 320
 Val Phe Thr Gly Tyr Ile Glu Asn Asn Tyr Gln His Ser Ile Phe Cys
                 325                 330                 335    
 Arg Lys Val Pro Lys Pro Glu Ala Leu Gln Glu Lys Pro Ala Trp Tyr
             340                 345                 350        
 Arg Phe Leu Leu Thr Ala Arg Phe Ser Glu Asp Thr Ala Glu Gly Glu
         355                 360                 365            
 Glu Ala Asn Thr Tyr Glu Ser His Leu Leu Val Cys Phe Leu Lys Arg
     370                 375                 380                
 Tyr Tyr Cys Asp Trp Ile Thr Asn Thr Tyr Val Lys Pro Phe Val Val
 385                 390                 395                 400
 Leu Phe Tyr Leu Ile Tyr Ile Ser Phe Ala Leu Met Gly Tyr Leu Gln
                 405                 410                 415    
 Val Ser Glu Gly Ser Asp Leu Ser Asn Ile Val Ala Thr Ala Thr Gln
             420                 425                 430        
 Thr Ile Glu Tyr Thr Thr Ala Gln Gln Lys Tyr Phe Ser Asn Tyr Ser
         435                 440                 445            
 Pro Val Ile Gly Phe Tyr Ile Tyr Glu Ser Ile Glu Tyr Trp Asn Thr
     450                 455                 460                
 Ser Val Gln Glu Asp Val Leu Glu Tyr Thr Lys Gly Phe Val Arg Ile
 465                 470                 475                 480
 Ser Trp Phe Glu Ser Tyr Leu Asn Tyr Leu Arg Lys Leu Asn Val Ser
                 485                 490                 495    
 Thr Gly Leu Pro Lys Lys Asn Phe Thr Asp Met Leu Arg Asn Ser Phe
             500                 505                 510        
 Leu Lys Ala Pro Gln Phe Ser His Phe Gln Glu Asp Ile Ile Phe Ser
         515                 520                 525            
 Lys Lys Tyr Asn Asp Glu Val Asp Val Val Ala Ser Arg Met Phe Leu
     530                 535                 540                
 Val Ala Lys Thr Met Glu Thr Asn Arg Glu Glu Leu Tyr Asp Leu Leu
 545                 550                 555                 560
 Glu Thr Leu Arg Arg Leu Ser Val Thr Ser Lys Val Lys Phe Ile Val
                 565                 570                 575    
 Phe Asn Pro Ser Phe Val Tyr Met Asp Arg Tyr Ala Ser Ser Leu Gly
             580                 585                 590        
 Ala Pro Leu His Asn Ser Cys Ile Ser Ala Leu Phe Leu Leu Phe Phe
         595                 600                 605            
 Ser Ala Phe Leu Val Ala Asp Ser Leu Ile Asn Val Trp Ile Thr Leu
     610                 615                 620                
 Thr Val Val Ser Val Glu Phe Gly Val Ile Gly Phe Met Thr Leu Trp
 625                 630                 635                 640
 Lys Val Glu Leu Asp Cys Ile Ser Val Leu Cys Leu Ile Tyr Gly Ile
                 645                 650                 655    
 Asn Tyr Thr Ile Asp Asn Cys Ala Pro Met Leu Ser Thr Phe Val Leu
             660                 665                 670        
 Gly Lys Asp Phe Thr Arg Thr Lys Trp Val Lys Asn Ala Leu Glu Val
         675                 680                 685            
 His Gly Val Ala Ile Leu Gln Ser Tyr Leu Cys Tyr Ile Val Gly Leu
     690                 695                 700                
 Ile Pro Leu Ala Ala Val Pro Ser Asn Leu Thr Cys Thr Leu Phe Arg
 705                 710                 715                 720
 Cys Leu Phe Leu Ile Ala Phe Val Thr Phe Phe His Cys Phe Ala Ile
                 725                 730                 735    
 Leu Pro Val Ile Leu Thr Phe Leu Pro Pro Ser Lys Lys Lys Arg Lys
             740                 745                 750        
 Glu Lys Lys Asn Pro Glu Asn Arg Glu Glu Ile Glu Cys Val Glu Met
         755                 760                 765            
 Val Asp Ile Asp Ser Thr Arg Val Val Asp Gln Ile Thr Thr Val
     770                 775                 780            



      <210> 407
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 407
 Met Ser Ala Gln Arg Leu Ile Ser Asn Arg Thr Ser Gln Gln Ser Ala
   1               5                  10                  15    
 Ser Asn Ser Asp Tyr Thr Trp Glu Tyr Glu Tyr Tyr Glu Ile Gly Pro
              20                  25                  30        
 Val Ser Phe Glu Gly Leu Lys Ala His Lys Tyr Ser Ile Val Ile Gly
          35                  40                  45            
 Phe Trp Val Gly Leu Ala Val Phe Val Ile Phe Met Phe Phe Val Leu
      50                  55                  60                
 Thr Leu Leu Thr Lys Thr Gly Ala Pro His Gln Asp Asn Ala Glu Ser
  65                  70                  75                  80
 Ser Glu Lys Arg Phe Arg Met Asn Ser Phe Val Ser Asp Phe Gly Arg
                  85                  90                  95    
 Pro Leu Glu Pro Asp Lys Val Phe Ser Arg Gln Gly Asn Glu Glu Ser
             100                 105                 110        
 Arg Ser Leu Phe His Cys Tyr Ile Asn Glu Val Glu Arg Leu Asp Arg
         115                 120                 125            
 Ala Lys Ala Cys His Gln Thr Thr Ala Leu Asp Ser Asp Val Gln Leu
     130                 135                 140                
 Gln Glu Ala Ile Arg Ser Ser Gly Gln Pro Glu Glu Glu Leu Asn Arg
 145                 150                 155                 160
 Leu Met Lys Phe Asp Ile Pro Asn Phe Val Asn Thr Asp Gln Asn Tyr
                 165                 170                 175    
 Phe Gly Glu Asp Asp Leu Leu Ile Ser Glu Pro Pro Ile Val Leu Glu
             180                 185                 190        
 Thr Lys Pro Leu Ser Gln Thr Ser His Lys Asp Leu Asp
         195                 200                 205



      <210> 408
      <211> 182
      <212> PRT
      <213> Homo sapiens


      <400> 408
 Met Trp Pro Pro Asp Pro Asp Pro Asp Pro Asp Pro Glu Pro Ala Gly
   1               5                  10                  15    
 Gly Ser Arg Pro Gly Pro Ala Val Pro Gly Leu Arg Ala Leu Leu Pro
              20                  25                  30        
 Ala Arg Ala Phe Leu Cys Ser Leu Lys Gly Arg Leu Leu Leu Ala Glu
          35                  40                  45            
 Ser Gly Leu Ser Phe Ile Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala
      50                  55                  60                
 Ser Ala Phe Leu Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr
  65                  70                  75                  80
 Phe Leu Phe Ala Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu
                  85                  90                  95    
 Cys Trp Pro Met Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile
             100                 105                 110        
 Tyr Phe Ala Ile Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala
         115                 120                 125            
 Ser Lys Ala Ala Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala
     130                 135                 140                
 Thr Asp Phe Tyr Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln
 145                 150                 155                 160
 Gly Asp Ser Ala Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn
                 165                 170                 175    
 Ser Asp Ser Asp Ser Asp
             180        



      <210> 409
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 409
 Met Ile Arg Val Pro Cys Ile Trp His Cys Leu Glu Gly Thr Tyr Thr
   1               5                  10                  15    
 Ala Glu Glu Gly Lys Gly Ser Asp Gly Val Met Glu Glu Val Trp Gln
              20                  25                  30        
 Gly Lys Gln Glu Gly Asp Ala Gly Arg Gln Met Val Asp Pro Arg Arg
          35                  40                  45            
 Thr Gly Lys Asn Cys Asn Arg Gly Ser Arg Gly Val Gln Ser Val Arg
      50                  55                  60                
 Gly Trp Lys Cys Glu Ser Gln Glu Leu Ser Gly Ile Trp Val Ala Ser
  65                  70                  75                  80
 Cys Thr Val Lys Glu Ser Val Thr Gln Ala Ser His Arg Trp His Thr
                  85                  90                  95    
 Tyr Arg Leu Gly Leu Ile Leu Asp Ser Cys Ser Glu Gln Ser Gly Arg
             100                 105                 110        
 Arg Gln Arg His Lys Pro Cys Glu Arg Cys Val Trp Asn His Leu Val
         115                 120                 125            
 Ser Lys Ser His Val Ile Pro Arg Ser Lys Glu Thr Gly Trp Ile Trp
     130                 135                 140                
 Gly Trp Ser Gly Met Lys Lys His Leu Ser Ala Ser Glu Gly Cys Met
 145                 150                 155                 160
 Ala His Gly Ser Ile Ser Ile Met Pro Cys Pro Phe Ala His Leu Val
                 165                 170                 175    
 Leu Leu Val Val Thr Ser Leu Val Thr Gly Lys Val Ser Lys Asp Ile
             180                 185                 190        
 Gly Val Glu His Pro Gly
         195            



      <210> 410
      <211> 843
      <212> PRT
      <213> Homo sapiens


      <400> 410
 Met Ala Pro Ala Gly Ala Leu Pro Val Arg Val Glu Ser Thr Pro Val
   1               5                  10                  15    
 Ala Leu Gly Ala Val Thr Lys Ala Pro Val Ser Val Cys Val Glu Pro
              20                  25                  30        
 Thr Ala Ser Gln Pro Leu Arg Ser Pro Val Gly Thr Leu Val Thr Lys
          35                  40                  45            
 Val Ala Pro Val Ser Ala Pro Pro Lys Val Ser Ser Gly Pro Arg Leu
      50                  55                  60                
 Pro Ala Pro Gln Ile Val Ala Val Lys Ala Pro Asn Thr Thr Thr Ile
  65                  70                  75                  80
 Gln Phe Pro Ala Asn Leu Gln Leu Pro Pro Gly Thr Val Leu Ile Lys
                  85                  90                  95    
 Ser Asn Ser Gly Pro Leu Met Leu Val Ser Pro Gln Gln Thr Val Thr
             100                 105                 110        
 Arg Ala Glu Thr Thr Ser Asn Ile Thr Ser Arg Pro Ala Val Pro Ala
         115                 120                 125            
 Asn Pro Gln Thr Val Lys Ile Cys Thr Val Pro Asn Ser Ser Ser Gln
     130                 135                 140                
 Leu Ile Lys Lys Val Ala Val Thr Pro Val Lys Lys Leu Ala Gln Ile
 145                 150                 155                 160
 Gly Thr Thr Val Val Thr Thr Val Pro Lys Pro Ser Ser Val Gln Ser
                 165                 170                 175    
 Val Ala Val Pro Thr Ser Val Val Thr Val Thr Pro Gly Lys Pro Leu
             180                 185                 190        
 Asn Thr Val Thr Thr Leu Lys Pro Ser Ser Leu Gly Ala Ser Ser Thr
         195                 200                 205            
 Pro Ser Asn Glu Pro Asn Leu Lys Ala Glu Asn Ser Ala Ala Val Gln
     210                 215                 220                
 Ile Asn Leu Ser Pro Thr Met Leu Glu Asn Val Lys Lys Cys Lys Asn
 225                 230                 235                 240
 Phe Leu Ala Met Leu Ile Lys Leu Ala Cys Ser Gly Ser Gln Ser Pro
                 245                 250                 255    
 Glu Met Gly Gln Asn Val Lys Lys Leu Val Glu Gln Leu Leu Asp Ala
             260                 265                 270        
 Lys Ile Glu Ala Glu Glu Phe Thr Arg Lys Leu Tyr Val Glu Leu Lys
         275                 280                 285            
 Ser Ser Pro Gln Pro His Leu Val Pro Phe Leu Lys Lys Ser Val Val
     290                 295                 300                
 Ala Leu Arg Gln Leu Leu Pro Asn Ser Gln Ser Phe Ile Gln Gln Cys
 305                 310                 315                 320
 Val Gln Gln Thr Ser Ser Asp Met Val Ile Ala Thr Cys Thr Thr Thr
                 325                 330                 335    
 Val Thr Thr Ser Pro Val Val Thr Thr Thr Val Ser Ser Ser Gln Ser
             340                 345                 350        
 Glu Lys Ser Ile Ile Val Ser Gly Ala Thr Ala Pro Arg Thr Val Ser
         355                 360                 365            
 Val Gln Thr Leu Asn Pro Leu Ala Gly Pro Val Gly Ala Lys Ala Gly
     370                 375                 380                
 Val Val Thr Leu His Ser Val Gly Pro Thr Ala Ala Thr Gly Gly Thr
 385                 390                 395                 400
 Thr Ala Gly Thr Gly Leu Leu Gln Thr Ser Lys Pro Leu Val Thr Ser
                 405                 410                 415    
 Val Ala Asn Thr Val Thr Thr Val Ser Leu Gln Pro Glu Lys Pro Val
             420                 425                 430        
 Val Ser Gly Thr Ala Val Thr Leu Ser Leu Pro Ala Val Thr Phe Gly
         435                 440                 445            
 Glu Thr Ser Gly Ala Ala Ile Cys Leu Pro Ser Val Lys Pro Val Val
     450                 455                 460                
 Ser Ser Ala Gly Thr Thr Ser Asp Lys Pro Val Ile Gly Thr Pro Val
 465                 470                 475                 480
 Gln Ile Lys Leu Ala Gln Pro Gly Pro Val Leu Ser Gln Pro Ala Gly
                 485                 490                 495    
 Ile Pro Gln Ala Val Gln Val Lys Gln Leu Phe Ser Leu Phe His Val
             500                 505                 510        
 Val Gln Gln Pro Ser Gly Gly Asn Glu Lys Gln Val Thr Thr Ile Ser
         515                 520                 525            
 His Ser Ser Thr Leu Thr Ile Gln Lys Cys Gly Gln Lys Thr Met Pro
     530                 535                 540                
 Val Asn Thr Ile Ile Pro Thr Ser Gln Phe Pro Pro Ala Ser Ile Leu
 545                 550                 555                 560
 Lys Gln Ile Thr Leu Pro Gly Asn Lys Ile Leu Ser Leu Gln Ala Ser
                 565                 570                 575    
 Pro Thr Gln Lys Asn Arg Ile Lys Glu Asn Val Thr Ser Cys Phe Arg
             580                 585                 590        
 Asp Glu Asp Asp Ile Asn Asp Val Thr Ser Met Ala Gly Val Asn Leu
         595                 600                 605            
 Asn Glu Glu Asn Ala Cys Ile Leu Ala Thr Asn Ser Glu Leu Val Gly
     610                 615                 620                
 Thr Leu Ile Gln Ser Cys Lys Asp Glu Pro Phe Leu Phe Ile Gly Ala
 625                 630                 635                 640
 Leu Gln Lys Arg Ile Leu Asp Ile Gly Lys Lys His Asp Ile Thr Glu
                 645                 650                 655    
 Leu Asn Ser Asp Ala Val Asn Leu Ile Ser Gln Ala Thr Gln Glu Arg
             660                 665                 670        
 Leu Arg Gly Leu Leu Glu Lys Leu Thr Ala Ile Ala Gln His Arg Met
         675                 680                 685            
 Thr Thr Tyr Lys Ala Ser Glu Asn Tyr Ile Leu Cys Ser Asp Thr Arg
     690                 695                 700                
 Ser Gln Leu Lys Phe Leu Glu Lys Leu Asp Gln Leu Glu Lys Gln Arg
 705                 710                 715                 720
 Lys Asp Leu Glu Glu Arg Glu Met Leu Leu Lys Ala Ala Lys Ser Arg
                 725                 730                 735    
 Ser Asn Lys Glu Asp Pro Glu Gln Leu Arg Leu Lys Gln Lys Ala Lys
             740                 745                 750        
 Glu Leu Gln Gln Leu Glu Leu Ala Gln Ile Gln His Arg Asp Ala Asn
         755                 760                 765            
 Leu Thr Ala Leu Ala Ala Ile Gly Pro Arg Lys Lys Arg Pro Leu Glu
     770                 775                 780                
 Ser Gly Ile Glu Gly Leu Lys Asp Asn Leu Leu Ala Ser Gly Thr Ser
 785                 790                 795                 800
 Ser Leu Thr Ala Thr Lys Gln Leu His Arg Pro Arg Ile Thr Arg Ile
                 805                 810                 815    
 Cys Leu Arg Asp Leu Ile Phe Cys Met Glu Gln Glu Arg Glu Met Lys
             820                 825                 830        
 Tyr Ser Arg Ala Leu Tyr Leu Ala Leu Leu Lys
         835                 840            



      <210> 411
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 411
 Met Asp Gly Thr Asn Gly Ser Thr Gln Thr His Phe Ile Leu Leu Gly
   1               5                  10                  15    
 Phe Ser Asp Arg Pro His Leu Glu Arg Ile Leu Phe Val Val Ile Leu
              20                  25                  30        
 Ile Ala Tyr Leu Leu Thr Leu Val Gly Asn Thr Thr Ile Ile Leu Val
          35                  40                  45            
 Ser Arg Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala
      50                  55                  60                
 His Leu Ser Phe Leu Asp Leu Ser Phe Thr Thr Ser Ser Ile Pro Gln
  65                  70                  75                  80
 Leu Leu Tyr Asn Leu Asn Gly Cys Asp Lys Thr Ile Ser Tyr Met Gly
                  85                  90                  95    
 Cys Ala Ile Gln Leu Phe Leu Phe Leu Gly Leu Gly Gly Val Glu Cys
             100                 105                 110        
 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Cys Val Ala Ile Cys Lys
         115                 120                 125            
 Pro Leu His Tyr Met Val Ile Met Asn Pro Arg Leu Cys Arg Gly Leu
     130                 135                 140                
 Val Ser Val Thr Trp Gly Cys Gly Val Ala Asn Ser Leu Ala Met Ser
 145                 150                 155                 160
 Pro Val Thr Leu Arg Leu Pro Arg Cys Gly His His Glu Val Asp His
                 165                 170                 175    
 Phe Leu Arg Glu Met Pro Ala Leu Ile Arg Met Ala Cys Val Ser Thr
             180                 185                 190        
 Val Ala Ile Glu Gly Thr Val Phe Val Leu Lys Lys Gly Val Val Leu
         195                 200                 205            
 Ser Pro Leu Val Phe Ile Leu Leu Ser Tyr Ser Tyr Ile Val Arg Ala
     210                 215                 220                
 Val Leu Gln Ile Arg Ser Ala Ser Gly Arg Gln Lys Ala Phe Gly Thr
 225                 230                 235                 240
 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Asn Ile Ile
                 245                 250                 255    
 Tyr Met Tyr Met Gln Pro Gly Ala Ser Ser Ser Gln Asp Gln Gly Lys
             260                 265                 270        
 Phe Leu Thr Leu Phe Tyr Asn Ile Val Thr Pro Leu Leu Asn Pro Leu
         275                 280                 285            
 Ile Tyr Thr Leu Arg Asn Arg Glu Val Lys Gly Ala Leu Gly Arg Leu
     290                 295                 300                
 Leu Leu Gly Lys Arg Glu Leu Gly Lys Glu
 305                 310                



      <210> 412
      <211> 344
      <212> PRT
      <213> Homo sapiens


      <400> 412
 Met Asp Leu His Leu Phe Asp Tyr Ser Glu Pro Gly Asn Phe Ser Asp
   1               5                  10                  15    
 Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys Ile Val Val Asp Thr Val
              20                  25                  30        
 Met Cys Pro Asn Met Pro Asn Gly Met Ile Ala Asn Ser Val Val Val
          35                  40                  45            
 Trp Val Asn Ile Gln Ala Lys Thr Thr Gly Tyr Asp Thr His Cys Tyr
      50                  55                  60                
 Ile Leu Asn Leu Ala Ile Ala Asp Leu Trp Val Val Leu Thr Ile Pro
  65                  70                  75                  80
 Val Trp Val Val Ser Leu Val Gln His Asn Gln Trp Pro Met Gly Glu
                  85                  90                  95    
 Leu Thr Cys Lys Val Thr His Leu Ile Phe Ser Ile Asn Leu Phe Gly
             100                 105                 110        
 Ser Ile Phe Phe Leu Thr Cys Met Ser Val Asp Arg Tyr Leu Ser Ile
         115                 120                 125            
 Thr Tyr Phe Thr Asn Thr Pro Ser Ser Arg Lys Lys Met Val Arg Arg
     130                 135                 140                
 Val Val Cys Ile Leu Val Trp Leu Leu Ala Phe Cys Val Ser Leu Pro
 145                 150                 155                 160
 Asp Thr Tyr Tyr Leu Lys Thr Val Thr Ser Ala Ser Asn Asn Glu Thr
                 165                 170                 175    
 Tyr Cys Arg Ser Phe Tyr Pro Glu His Ser Ile Lys Glu Trp Leu Ile
             180                 185                 190        
 Gly Met Glu Leu Val Ser Val Val Leu Gly Phe Ala Val Pro Phe Ser
         195                 200                 205            
 Ile Ile Ala Val Phe Tyr Phe Leu Leu Ala Arg Ala Ile Ser Ala Ser
     210                 215                 220                
 Ser Asp Gln Glu Lys His Ser Ser Arg Lys Ile Ile Phe Ser Tyr Val
 225                 230                 235                 240
 Val Val Phe Leu Val Cys Trp Leu Pro Tyr His Val Ala Val Leu Leu
                 245                 250                 255    
 Asp Ile Phe Ser Ile Leu His Tyr Ile Pro Phe Thr Cys Arg Leu Glu
             260                 265                 270        
 His Ala Leu Phe Thr Ala Leu His Val Thr Gln Cys Leu Ser Leu Val
         275                 280                 285            
 His Cys Cys Val Asn Pro Val Leu Tyr Ser Phe Ile Asn Arg Asn Tyr
     290                 295                 300                
 Arg Tyr Glu Leu Met Lys Ala Phe Ile Phe Lys Tyr Ser Ala Lys Thr
 305                 310                 315                 320
 Gly Leu Thr Lys Leu Ile Asp Ala Ser Arg Val Ser Glu Thr Glu Tyr
                 325                 330                 335    
 Ser Ala Leu Glu Gln Ser Thr Lys
             340                



      <210> 413
      <211> 387
      <212> PRT
      <213> Homo sapiens


      <400> 413
 Met Gly Gly Gly Pro Ala Ala Gly Gly Pro Gly Arg Val Thr Pro Gly
   1               5                  10                  15    
 Ala Arg Pro Ala Pro Asp Pro Asp Pro Arg Ala Ser Pro Pro Cys Thr
              20                  25                  30        
 Leu Pro Pro Ala Pro Gly Val Arg Thr Met Leu Lys Ser Arg Leu Arg
          35                  40                  45            
 Met Phe Leu Asn Glu Leu Lys Leu Leu Val Leu Thr Gly Gly Gly Arg
      50                  55                  60                
 Pro Arg Ala Glu Pro Gln Pro Arg Gly Gly Arg Gly Gly Gly Cys Gly
  65                  70                  75                  80
 Trp Ala Pro Phe Ala Gly Cys Ser Thr Arg Asp Gly Asp Gly Asp Glu
                  85                  90                  95    
 Glu Glu Tyr Tyr Gly Ser Glu Pro Arg Ala Arg Gly Leu Ala Gly Asp
             100                 105                 110        
 Lys Glu Pro Arg Ala Gly Pro Leu Pro Pro Pro Ala Pro Pro Leu Pro
         115                 120                 125            
 Pro Pro Gly Ala Leu Asp Ala Leu Ser Leu Ser Ser Ser Leu Asp Ser
     130                 135                 140                
 Gly Leu Arg Thr Pro Gln Cys Arg Ile Cys Phe Gln Gly Pro Glu Gln
 145                 150                 155                 160
 Gly Glu Leu Leu Ser Pro Cys Arg Cys Asp Gly Ser Val Arg Cys Thr
                 165                 170                 175    
 His Gln Pro Cys Leu Ile Arg Trp Ile Ser Glu Arg Gly Ser Trp Ser
             180                 185                 190        
 Cys Glu Leu Cys Tyr Phe Lys Tyr Gln Val Leu Ala Ile Ser Thr Lys
         195                 200                 205            
 Asn Pro Leu Gln Trp Gln Ala Ile Ser Leu Thr Val Ile Glu Lys Val
     210                 215                 220                
 Gln Ile Ala Ala Ile Val Leu Gly Ser Leu Phe Leu Val Ala Ser Ile
 225                 230                 235                 240
 Ser Trp Leu Ile Trp Ser Ser Leu Ser Pro Ser Ala Lys Trp Gln Arg
                 245                 250                 255    
 Gln Asp Leu Leu Phe Gln Ile Cys Tyr Gly Met Tyr Gly Phe Met Asp
             260                 265                 270        
 Val Val Cys Ile Gly Leu Ile Ile His Glu Gly Ser Ser Val Tyr Arg
         275                 280                 285            
 Ile Phe Lys Arg Trp Gln Ala Val Asn Gln Gln Trp Lys Val Leu Asn
     290                 295                 300                
 Tyr Asp Lys Thr Lys Asp Ile Gly Gly Asp Ala Gly Gly Gly Thr Ala
 305                 310                 315                 320
 Gly Lys Ser Gly Pro Arg Asn Ser Arg Thr Gly Pro Thr Ser Gly Ala
                 325                 330                 335    
 Thr Ser Arg Pro Pro Ala Ala Gln Arg Met Arg Thr Leu Leu Pro Gln
             340                 345                 350        
 Arg Cys Gly Tyr Thr Ile Leu His Leu Leu Gly Gln Leu Arg Pro Pro
         355                 360                 365            
 Asp Ala Arg Ser Ser Ser His Ser Gly Arg Glu Val Val Met Arg Val
     370                 375                 380                
 Thr Thr Val
 385        



      <210> 414
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 414
 Met Ala Ala Gly Gly Arg Met Glu Asp Gly Ser Leu Asp Ile Thr Gln
   1               5                  10                  15    
 Ser Ile Glu Asp Asp Pro Leu Leu Asp Ala Gln Leu Leu Pro His His
              20                  25                  30        
 Ser Leu Gln Ala His Phe Arg Pro Arg Phe His Pro Leu Pro Thr Val
          35                  40                  45            
 Ile Ile Val Asn Leu Leu Trp Phe Ile His Leu Val Phe Val Val Leu
      50                  55                  60                
 Ala Phe Leu Thr Gly Val Leu Cys Ser Tyr Pro Asn Pro Asn Glu Asp
  65                  70                  75                  80
 Lys Cys Pro Gly Asn Tyr Thr Asn Pro Leu Lys Val Gln Thr Val Ile
                  85                  90                  95    
 Ile Leu Gly Lys Val Ile Leu Trp Ile Leu His Leu Leu Leu Glu Cys
             100                 105                 110        
 Tyr Ile Gln Tyr His His Ser Lys Ile Arg Asn Arg Gly Tyr Asn Leu
         115                 120                 125            
 Ile Tyr Arg Ser Thr Arg His Leu Lys Arg Leu Ala Leu Met Ile Gln
     130                 135                 140                
 Ser Ser Gly Asn Thr Val Leu Leu Leu Ile Leu Cys Met Gln His Ser
 145                 150                 155                 160
 Phe Pro Glu Pro Gly Arg Leu Tyr Leu Asp Leu Ile Leu Ala Ile Leu
                 165                 170                 175    
 Ala Leu Glu Leu Ile Cys Ser Leu Ile Cys Leu Leu Ile Tyr Thr Val
             180                 185                 190        
 Lys Ile Arg Arg Phe Asn Lys Ala Lys Pro Glu Pro Asp Ile Leu Glu
         195                 200                 205            
 Glu Glu Lys Ile Tyr Ala Tyr Pro Ser Asn Ile Thr Ser Glu Thr Gly
     210                 215                 220                
 Phe Arg Thr Ile Ser Ser Leu Glu Glu Ile Val Glu Lys Gln Gly Asp
 225                 230                 235                 240
 Thr Ile Glu Tyr Leu Lys Arg His Asn Ala Leu Leu Ser Lys Arg Leu
                 245                 250                 255    
 Leu Ala Leu Thr Ser Ser Asp Leu Gly Cys Gln Pro Ser Arg Thr
             260                 265                 270    



      <210> 415
      <211> 1110
      <212> PRT
      <213> Homo sapiens


      <400> 415
 Met Val Phe Leu Lys Arg Gly Thr Val Pro Asp Ser Glu Lys Met Leu
   1               5                  10                  15    
 Thr Gly Leu Pro Val Glu Ala Thr Leu Arg Asn Pro Gly Glu Thr Arg
              20                  25                  30        
 Glu Thr Glu Ala Leu Lys Gly Asp Gln Arg Ser Ser Pro His Phe Pro
          35                  40                  45            
 Gly Leu Pro Ala Leu Ala His Glu Gln Gly Asn Lys Gly Leu Arg Leu
      50                  55                  60                
 Ser Gln Thr Gly Trp Cys Gly Leu Gly Ile Leu Leu Val Thr Ser Pro
  65                  70                  75                  80
 Ala Lys Val Pro Gln Pro Leu Cys Pro Lys Met Gly Arg Gly Ala Gly
                  85                  90                  95    
 Arg Glu Tyr Ser Pro Ala Ala Thr Thr Ala Glu Asn Gly Gly Gly Lys
             100                 105                 110        
 Lys Lys Gln Lys Glu Lys Glu Leu Asp Glu Leu Lys Lys Glu Val Ala
         115                 120                 125            
 Met Asp Asp His Lys Leu Ser Leu Asp Glu Leu Gly Arg Lys Tyr Gln
     130                 135                 140                
 Val Asp Leu Ser Lys Gly Leu Thr Asn Gln Arg Ala Gln Asp Val Leu
 145                 150                 155                 160
 Ala Arg Asp Gly Pro Asn Ala Leu Thr Pro Pro Pro Thr Thr Pro Glu
                 165                 170                 175    
 Trp Val Lys Phe Cys Arg Gln Leu Phe Gly Gly Phe Ser Ile Leu Leu
             180                 185                 190        
 Trp Ile Gly Ala Ile Leu Cys Phe Leu Ala Tyr Gly Ile Gln Ala Ala
         195                 200                 205            
 Met Glu Asp Glu Pro Ser Asn Asp Asn Leu Tyr Leu Gly Val Val Leu
     210                 215                 220                
 Ala Ala Val Val Ile Val Thr Gly Cys Phe Ser Tyr Tyr Gln Glu Ala
 225                 230                 235                 240
 Lys Ser Ser Lys Ile Met Asp Ser Phe Lys Asn Met Val Pro Gln Gln
                 245                 250                 255    
 Ala Leu Val Ile Arg Glu Gly Glu Lys Met Gln Ile Asn Ala Glu Glu
             260                 265                 270        
 Val Val Val Gly Asp Leu Val Glu Val Lys Gly Gly Asp Arg Val Pro
         275                 280                 285            
 Ala Asp Leu Arg Ile Ile Ser Ser His Gly Cys Lys Val Asp Asn Ser
     290                 295                 300                
 Ser Leu Thr Gly Glu Ser Glu Pro Gln Thr Arg Ser Pro Glu Phe Thr
 305                 310                 315                 320
 His Glu Asn Pro Leu Glu Thr Arg Asn Ile Cys Phe Phe Ser Thr Asn
                 325                 330                 335    
 Cys Val Glu Gly Thr Ala Arg Gly Ile Val Ile Ala Thr Gly Asp Arg
             340                 345                 350        
 Thr Val Met Gly Arg Ile Ala Thr Leu Ala Ser Gly Leu Glu Val Gly
         355                 360                 365            
 Arg Thr Pro Ile Ala Met Glu Ile Glu His Phe Ile Gln Leu Ile Thr
     370                 375                 380                
 Gly Val Ala Val Phe Leu Gly Val Ser Phe Phe Val Leu Ser Leu Ile
 385                 390                 395                 400
 Leu Gly Tyr Ser Trp Leu Glu Ala Val Ile Phe Leu Ile Gly Ile Ile
                 405                 410                 415    
 Val Ala Asn Val Pro Glu Gly Leu Leu Ala Thr Val Thr Val Cys Leu
             420                 425                 430        
 Thr Leu Thr Ala Lys Arg Met Ala Arg Lys Asn Cys Leu Val Lys Asn
         435                 440                 445            
 Leu Glu Ala Val Glu Thr Leu Gly Ser Thr Ser Thr Ile Cys Ser Asp
     450                 455                 460                
 Lys Thr Gly Thr Leu Thr Gln Asn Arg Met Thr Val Ala His Met Trp
 465                 470                 475                 480
 Phe Asp Asn Gln Ile His Glu Ala Asp Thr Thr Glu Asp Gln Ser Gly
                 485                 490                 495    
 Ala Thr Phe Asp Lys Arg Ser Pro Thr Trp Thr Ala Leu Ser Arg Ile
             500                 505                 510        
 Ala Gly Leu Cys Asn Arg Ala Val Phe Lys Ala Gly Gln Glu Asn Ile
         515                 520                 525            
 Ser Val Ser Lys Arg Asp Thr Ala Gly Asp Ala Ser Glu Ser Ala Leu
     530                 535                 540                
 Leu Lys Cys Ile Glu Leu Ser Cys Gly Ser Val Arg Lys Met Arg Asp
 545                 550                 555                 560
 Arg Asn Pro Lys Val Ala Glu Ile Pro Phe Asn Ser Thr Asn Lys Tyr
                 565                 570                 575    
 Gln Leu Ser Ile His Glu Arg Glu Asp Ser Pro Gln Ser His Val Leu
             580                 585                 590        
 Val Met Lys Gly Ala Pro Glu Arg Ile Leu Asp Arg Cys Ser Thr Ile
         595                 600                 605            
 Leu Val Gln Gly Lys Glu Ile Pro Leu Asp Lys Glu Met Gln Asp Ala
     610                 615                 620                
 Phe Gln Asn Ala Tyr Met Glu Leu Gly Gly Leu Gly Glu Arg Val Leu
 625                 630                 635                 640
 Gly Phe Cys Gln Leu Asn Leu Pro Ser Gly Lys Phe Pro Arg Gly Phe
                 645                 650                 655    
 Lys Phe Asp Ser Gly Glu Leu Asn Phe Pro Thr Glu Lys Leu Cys Phe
             660                 665                 670        
 Val Gly Leu Met Ser Met Ile Asp Pro Pro Arg Ala Ala Val Pro Asp
         675                 680                 685            
 Ala Val Gly Lys Cys Arg Ser Ala Gly Ile Lys Val Ile Met Val Thr
     690                 695                 700                
 Gly Asp His Pro Ile Thr Ala Lys Ala Ile Ala Lys Gly Val Gly Ile
 705                 710                 715                 720
 Ile Ser Glu Gly Asn Glu Thr Val Glu Asp Ile Ala Ala Arg Leu Asn
                 725                 730                 735    
 Ile Pro Met Ser Gln Val Asn Pro Arg Glu Ala Lys Ala Cys Val Val
             740                 745                 750        
 His Gly Ser Asp Leu Lys Asp Met Thr Ser Glu Gln Leu Asp Glu Ile
         755                 760                 765            
 Leu Lys Asn His Thr Glu Ile Val Phe Ala Arg Thr Ser Pro Gln Gln
     770                 775                 780                
 Lys Leu Ile Ile Val Glu Gly Cys Gln Arg Gln Gly Ala Ile Val Ala
 785                 790                 795                 800
 Val Thr Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Lys Lys Ala Asp
                 805                 810                 815    
 Ile Gly Ile Ala Met Gly Ile Ser Gly Ser Asp Val Ser Lys Gln Ala
             820                 825                 830        
 Ala Asp Met Ile Leu Leu Asp Asp Asn Phe Ala Ser Ile Val Thr Gly
         835                 840                 845            
 Val Glu Glu Gly Arg Leu Ile Phe Asp Asn Leu Lys Lys Ser Ile Ala
     850                 855                 860                
 Tyr Thr Leu Thr Ser Asn Ile Pro Glu Ile Thr Pro Phe Leu Leu Phe
 865                 870                 875                 880
 Ile Ile Ala Asn Ile Pro Leu Pro Leu Gly Thr Val Thr Ile Leu Cys
                 885                 890                 895    
 Ile Asp Leu Gly Thr Asp Met Val Pro Ala Ile Ser Leu Ala Tyr Glu
             900                 905                 910        
 Ala Ala Glu Ser Asp Ile Met Lys Arg Gln Pro Arg Asn Ser Gln Thr
         915                 920                 925            
 Asp Lys Leu Val Asn Glu Arg Leu Ile Ser Met Ala Tyr Gly Gln Ile
     930                 935                 940                
 Gly Met Ile Gln Ala Leu Gly Gly Phe Phe Thr Tyr Phe Val Ile Leu
 945                 950                 955                 960
 Ala Glu Asn Gly Phe Leu Pro Ser Arg Leu Leu Gly Ile Arg Leu Asp
                 965                 970                 975    
 Trp Asp Asp Arg Thr Met Asn Asp Leu Glu Asp Ser Tyr Gly Gln Glu
             980                 985                 990        
 Trp Thr Tyr Glu Gln Arg Lys Val Val Glu Phe Thr Cys His Thr Ala
         995                1000                1005            
 Phe Phe Ala Ser Ile Val Val Val Gln Trp Ala Asp Leu Ile Ile Cys
    1010                1015                1020                
 Lys Thr Arg Arg Asn Ser Val Phe Gln Gln Gly Met Lys Asn Lys Ile
1025                1030                1035                1040
 Leu Ile Phe Gly Leu Leu Glu Glu Thr Ala Leu Ala Ala Phe Leu Ser
                1045                1050                1055    
 Tyr Cys Pro Gly Met Gly Val Ala Leu Arg Met Tyr Pro Leu Lys Val
            1060                1065                1070        
 Thr Trp Trp Phe Cys Ala Phe Pro Tyr Ser Leu Leu Ile Phe Ile Tyr
        1075                1080                1085            
 Asp Glu Val Arg Lys Leu Ile Leu Arg Arg Tyr Pro Gly Gly Trp Val
    1090                1095                1100                
 Glu Lys Glu Thr Tyr Tyr
1105                1110



      <210> 416
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 416
 Met Gly Pro Gly Ile Arg Leu Phe Ser Ser Ile Pro Pro Asn Asp Thr
   1               5                  10                  15    
 Ala Ala Ser Gln Ser Gly Gly Gly Val Cys Gly Ser Gly Arg Gly Arg
              20                  25                  30        
 Pro Pro Ala Gly Glu Gly Ala Val Arg Ala Ala Leu Gly Ala Gly Arg
          35                  40                  45            
 Gly Arg Ser Ala Gly Arg Arg Leu Leu Trp Arg Leu Pro Arg Leu Arg
      50                  55                  60                
 Leu Ala Ala Ser Gly Pro Ala Pro Val Thr Leu Gly Arg Ala Arg Pro
  65                  70                  75                  80
 Arg Pro Ala Arg Arg Arg Ser Pro Met Ala Pro Ser Arg Leu Gln Leu
                  85                  90                  95    
 Gly Leu Arg Ala Ala Tyr Ser Gly Ile Ser Ser Val Ala Gly Phe Ser
             100                 105                 110        
 Ile Phe Leu Val Trp Thr Val Val Tyr Arg Gln Pro Gly Thr Ala Ala
         115                 120                 125            
 Met Gly Gly Leu Ala Gly Val Leu Ala Leu Trp Val Leu Val Thr His
     130                 135                 140                
 Val Met Tyr Met Gln Asp Tyr Trp Arg Thr Trp Leu Lys Gly Leu Arg
 145                 150                 155                 160
 Gly Phe Phe Phe Val Gly Val Leu Phe Ser Ala Val Ser Ile Ala Ala
                 165                 170                 175    
 Phe Cys Thr Phe Leu Val Leu Ala Ile Thr Arg His Gln Ser Leu Thr
             180                 185                 190        
 Asp Pro Thr Ser Tyr Tyr Leu Ser Ser Val Trp Ser Phe Ile Ser Phe
         195                 200                 205            
 Lys Trp Ala Phe Leu Leu Ser Leu Tyr Ala His Arg Tyr Arg Ala Asp
     210                 215                 220                
 Phe Ala Asp Ile Ser Ile Leu Ser Asp Phe
 225                 230                



      <210> 417
      <211> 409
      <212> PRT
      <213> Homo sapiens


      <400> 417
 Met Gln Gly Phe Ile Cys Lys Gln Thr Asp Gln Val Val Leu Ile Leu
   1               5                  10                  15    
 Asp Ser Ala Asp Ala Ile Trp Ala Ile Gln Lys Leu Tyr Pro Val Val
              20                  25                  30        
 Ser Val Thr Ser Gly Phe Val Asp Val Phe Ser Ser Val Asn Ala Asn
          35                  40                  45            
 Ile Pro Cys Ser Thr Ser Gly Ser Val Ser Thr Phe Tyr Ser Ile Leu
      50                  55                  60                
 Pro Ile Arg Gln Ile Thr Lys Val Cys Phe Met Asp Gln Thr Pro Gln
  65                  70                  75                  80
 Val Leu Arg Phe Phe Leu Leu Gly Asn Lys Ser Thr Ser Lys Leu Leu
                  85                  90                  95    
 Leu Ala Val Phe Tyr His Glu Leu Gln Ser Pro His Val Phe Leu Gly
             100                 105                 110        
 Glu Ser Phe Ile Pro Pro Thr Leu Val Gln Ser Ala Ser Leu Leu Leu
         115                 120                 125            
 Asn Glu Ser Ile Gly Ala Asn Tyr Phe Asn Ile Met Asp Asn Leu Leu
     130                 135                 140                
 Tyr Val Val Leu Gln Gly Glu Glu Pro Ile Glu Ile Arg Ser Gly Val
 145                 150                 155                 160
 Ser Ile His Leu Ala Leu Thr Val Met Val Ser Val Leu Glu Lys Gly
                 165                 170                 175    
 Trp Glu Ile Val Ile Leu Glu Arg Leu Thr Asn Phe Leu Gln Ile Gly
             180                 185                 190        
 Gln Asn Gln Ile Arg Phe Ile His Glu Met Pro Gly His Glu Glu Thr
         195                 200                 205            
 Leu Lys Ala Ile Ala Asp Ser Arg Ala Lys Arg Lys Arg Asn Cys Pro
     210                 215                 220                
 Thr Val Thr Cys Thr Ser His Tyr Arg Arg Val Gly Gln Arg Arg Pro
 225                 230                 235                 240
 Leu Met Met Glu Met Asn Ser His Arg Ala Ser Pro Pro Met Thr Val
                 245                 250                 255    
 Glu Thr Ile Ser Lys Val Ile Val Ile Glu Ile Gly Asp Ser Pro Thr
             260                 265                 270        
 Val Arg Ser Thr Gly Met Ile Ser Ser Leu Ser Ser Asn Lys Leu Gln
         275                 280                 285            
 Asn Leu Ala His Arg Val Ile Thr Ala Gln Gln Thr Gly Val Leu Glu
     290                 295                 300                
 Asn Val Leu Asn Met Thr Ile Gly Ala Leu Leu Val Thr Gln Ser Lys
 305                 310                 315                 320
 Gly Val Ile Gly Tyr Gly Asn Thr Ser Ser Phe Lys Thr Gly Asn Leu
                 325                 330                 335    
 Ile Tyr Ile Arg Pro Tyr Ala Leu Ser Ile Leu Val Gln Pro Ser Asp
             340                 345                 350        
 Gly Glu Val Gly Asn Glu Leu Pro Val Gln Pro Gln Leu Val Phe Leu
         355                 360                 365            
 Asp Glu Gln Tyr His Gly Leu Gly Gln Gly Ala Ile Tyr Gln Val Gln
     370                 375                 380                
 Tyr Asp Phe Tyr Gly Glu Ile Glu Arg Leu Ala Leu Ser Gly Met Lys
 385                 390                 395                 400
 Asn Lys Cys Asp Asp Leu Ile His Thr
                 405                



      <210> 418
      <211> 945
      <212> PRT
      <213> Homo sapiens


      <400> 418
 Met Glu Met Lys Leu Pro Gly Gln Glu Gly Phe Glu Ala Ser Ser Ala
   1               5                  10                  15    
 Pro Arg Asn Ile Pro Ser Gly Glu Leu Asp Ser Asn Pro Asp Pro Gly
              20                  25                  30        
 Thr Gly Pro Ser Pro Asp Gly Pro Ser Asp Thr Glu Ser Lys Glu Leu
          35                  40                  45            
 Gly Val Pro Lys Asp Pro Leu Leu Phe Ile Gln Leu Asn Glu Leu Leu
      50                  55                  60                
 Gly Trp Pro Gln Ala Leu Glu Trp Arg Glu Thr Gly Arg Trp Val Leu
  65                  70                  75                  80
 Phe Glu Glu Lys Leu Glu Val Ala Ala Gly Arg Trp Ser Ala Pro His
                  85                  90                  95    
 Val Pro Thr Leu Ala Leu Pro Ser Leu Gln Lys Leu Arg Ser Leu Leu
             100                 105                 110        
 Ala Glu Gly Leu Val Leu Leu Asp Cys Pro Ala Gln Ser Leu Leu Glu
         115                 120                 125            
 Leu Val Glu Gln Val Thr Arg Val Glu Ser Leu Ser Pro Glu Leu Arg
     130                 135                 140                
 Gly Gln Leu Gln Ala Leu Leu Leu Gln Arg Pro Gln His Tyr Asn Gln
 145                 150                 155                 160
 Thr Thr Gly Thr Arg Pro Cys Trp Gly Ser Thr His Pro Arg Lys Ala
                 165                 170                 175    
 Ser Asp Asn Glu Glu Ala Pro Leu Arg Glu Gln Cys Gln Asn Pro Leu
             180                 185                 190        
 Arg Gln Lys Leu Pro Pro Gly Ala Glu Ala Gly Thr Val Leu Ala Gly
         195                 200                 205            
 Glu Leu Gly Phe Leu Ala Gln Pro Leu Gly Ala Phe Val Arg Leu Arg
     210                 215                 220                
 Asn Pro Val Val Leu Gly Ser Leu Thr Glu Val Ser Leu Pro Ser Arg
 225                 230                 235                 240
 Phe Phe Cys Leu Leu Leu Gly Pro Cys Met Leu Gly Lys Gly Tyr His
                 245                 250                 255    
 Glu Met Gly Arg Ala Ala Ala Val Leu Leu Ser Asp Pro Gln Phe Gln
             260                 265                 270        
 Trp Ser Val Arg Arg Ala Ser Asn Leu His Asp Leu Leu Ala Ala Leu
         275                 280                 285            
 Asp Ala Phe Leu Glu Glu Val Thr Val Leu Pro Pro Gly Arg Trp Asp
     290                 295                 300                
 Pro Thr Ala Arg Ile Pro Pro Pro Lys Cys Leu Pro Ser Gln His Lys
 305                 310                 315                 320
 Arg Leu Pro Ser Gln Gln Arg Glu Ile Arg Gly Pro Ala Val Pro Arg
                 325                 330                 335    
 Leu Thr Ser Ala Glu Asp Arg His Arg His Gly Pro His Ala His Ser
             340                 345                 350        
 Pro Glu Leu Gln Arg Thr Gly Arg Lys Val Pro Trp Tyr Pro Ser Asp
         355                 360                 365            
 Phe Leu Asp Ala Leu His Leu Gln Cys Phe Ser Ala Val Leu Tyr Ile
     370                 375                 380                
 Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly Leu Leu Gly
 385                 390                 395                 400
 Asp Ala Thr Asp Gly Ala Gln Gly Val Leu Glu Ser Phe Leu Gly Thr
                 405                 410                 415    
 Ala Met Ala Gly Ala Ala Phe Cys Leu Met Ala Gly Gln Pro Leu Thr
             420                 425                 430        
 Ile Leu Ser Ser Thr Gly Pro Val Leu Val Phe Glu Arg Leu Leu Phe
         435                 440                 445            
 Ser Phe Ser Arg Asp Tyr Ser Leu Asp Tyr Leu Pro Phe Arg Leu Trp
     450                 455                 460                
 Val Gly Ile Trp Val Ala Thr Phe Cys Leu Val Leu Val Ala Thr Glu
 465                 470                 475                 480
 Ala Ser Val Leu Val Arg Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe
                 485                 490                 495    
 Cys Ala Leu Ile Ser Leu Ile Phe Ile Tyr Asp Ala Val Gly Lys Met
             500                 505                 510        
 Leu Asn Leu Thr His Thr Tyr Pro Ile Gln Lys Pro Gly Ser Ser Ala
         515                 520                 525            
 Tyr Gly Cys Leu Cys Gln Tyr Pro Gly Pro Gly Gly Asn Glu Ser Gln
     530                 535                 540                
 Trp Ile Arg Thr Arg Pro Lys Asp Arg Asp Asp Ile Asp Leu Gly Leu
 545                 550                 555                 560
 Ile Asn Ala Ser Leu Leu Pro Pro Pro Glu Cys Thr Arg Gln Gly Gly
                 565                 570                 575    
 His Pro Arg Gly Pro Gly Cys His Thr Val Pro Asp Ile Ala Phe Phe
             580                 585                 590        
 Ser Leu Leu Leu Phe Leu Thr Ser Phe Phe Phe Ala Met Ala Leu Lys
         595                 600                 605            
 Cys Val Lys Thr Ser Arg Phe Phe Pro Ser Val Val Arg Lys Gly Leu
     610                 615                 620                
 Ser Asp Phe Ser Ser Val Leu Ala Ile Leu Leu Gly Cys Gly Leu Asp
 625                 630                 635                 640
 Ala Phe Leu Gly Leu Ala Thr Pro Lys Leu Met Val Pro Arg Glu Phe
                 645                 650                 655    
 Lys Pro Thr Leu Pro Gly Arg Gly Trp Leu Val Ser Pro Phe Gly Ala
             660                 665                 670        
 Asn Pro Trp Trp Trp Ser Val Ala Ala Ala Leu Pro Ala Leu Leu Leu
         675                 680                 685            
 Ser Ile Leu Ile Phe Met Asp Gln Gln Ile Thr Ala Val Ile Leu Asn
     690                 695                 700                
 Arg Met Glu Tyr Arg Leu Gln Lys Gly Ala Gly Phe His Leu Asp Leu
 705                 710                 715                 720
 Phe Cys Val Ala Val Leu Met Leu Leu Thr Ser Ala Leu Gly Leu Pro
                 725                 730                 735    
 Trp Tyr Val Ser Ala Thr Val Ile Ser Leu Ala His Met Asp Ser Leu
             740                 745                 750        
 Arg Arg Glu Ser Lys Ala Cys Ala Pro Gly Glu Arg Pro Asn Phe Leu
         755                 760                 765            
 Gly Ile Arg Glu Gln Arg Leu Thr Gly Leu Val Val Phe Ile Leu Thr
     770                 775                 780                
 Gly Ala Ser Ile Phe Leu Ala Pro Val Leu Lys Phe Ile Pro Met Pro
 785                 790                 795                 800
 Val Leu Tyr Gly Ile Phe Leu Tyr Met Gly Val Ala Ala Leu Ser Ser
                 805                 810                 815    
 Ile Gln Phe Thr Asn Arg Val Lys Leu Leu Leu Met Pro Ala Lys His
             820                 825                 830        
 Gln Pro Asp Leu Leu Leu Leu Arg His Val Pro Leu Thr Arg Val His
         835                 840                 845            
 Leu Phe Thr Ala Ile Gln Leu Ala Cys Leu Gly Leu Leu Trp Ile Ile
     850                 855                 860                
 Lys Ser Thr Pro Ala Ala Ile Ile Phe Pro Leu Met Leu Leu Gly Leu
 865                 870                 875                 880
 Val Gly Val Arg Lys Ala Leu Glu Arg Val Phe Ser Pro Gln Glu Leu
                 885                 890                 895    
 Leu Trp Leu Asp Glu Leu Met Pro Glu Glu Glu Arg Ser Ile Pro Glu
             900                 905                 910        
 Lys Gly Leu Glu Pro Glu His Ser Phe Ser Gly Ser Asp Ser Glu Asp
         915                 920                 925            
 Ser Glu Leu Met Tyr Gln Pro Lys Ala Pro Glu Ile Asn Ile Ser Val
     930                 935                 940                
 Asn
 945



      <210> 419
      <211> 276
      <212> PRT
      <213> Homo sapiens


      <400> 419
 Met Ser Leu Leu Glu Glu Lys Leu Leu Pro Val Leu Val Ser Val Pro
   1               5                  10                  15    
 Arg Pro Pro Ser Ile His Gly Gln Pro Gly Arg Val Arg Glu His Thr
              20                  25                  30        
 Asp Pro His Thr Gly Ser Gly Lys His Gly Gly Gln Lys Pro Thr Leu
          35                  40                  45            
 Asn Gln Thr Gly Ala Leu Ala Gln Thr Tyr Leu Phe Leu Pro Ala His
      50                  55                  60                
 Pro Ile Gln Val His Thr Phe Trp Ile Asp Thr Lys Asn Tyr Val Glu
  65                  70                  75                  80
 Val Thr Arg Lys Trp Tyr Ala Glu Ala Met Pro Phe Pro Leu Asn Phe
                  85                  90                  95    
 Phe Leu Pro Gly Arg Met Gln Arg Gln Tyr Met Glu Arg Leu Gln Leu
             100                 105                 110        
 Leu Thr Gly Glu His Arg Pro Glu Asp Glu Glu Glu Leu Glu Lys Glu
         115                 120                 125            
 Leu Tyr Arg Glu Ala Arg Glu Cys Leu Thr Leu Leu Ser Gln Arg Leu
     130                 135                 140                
 Gly Ser Gln Lys Phe Phe Phe Gly Asp Ala Pro Ala Ser Leu Asp Ala
 145                 150                 155                 160
 Phe Val Phe Ser Tyr Leu Ala Leu Leu Leu Gln Ala Lys Leu Pro Ser
                 165                 170                 175    
 Gly Lys Leu Gln Val His Leu Arg Gly Leu His Asn Leu Cys Ala Tyr
             180                 185                 190        
 Cys Thr His Ile Leu Ser Leu Tyr Phe Pro Trp Asp Gly Ala Glu Val
         195                 200                 205            
 Pro Pro Gln Arg Gln Thr Pro Ala Gly Pro Glu Thr Glu Glu Glu Pro
     210                 215                 220                
 Tyr Arg Arg Arg Asn Gln Ile Leu Ser Val Leu Ala Gly Leu Ala Ala
 225                 230                 235                 240
 Met Val Gly Tyr Ala Leu Leu Ser Gly Ile Val Ser Ile Gln Arg Ala
                 245                 250                 255    
 Thr Pro Ala Arg Ala Pro Gly Thr Arg Thr Leu Gly Met Ala Glu Glu
             260                 265                 270        
 Asp Glu Glu Glu
         275    



      <210> 420
      <211> 386
      <212> PRT
      <213> Homo sapiens


      <400> 420
 Met Gly Arg Arg Pro Pro Ser Pro Glu Ala Arg Gly Pro Val Pro Arg
   1               5                  10                  15    
 Ser Ser Ala Ala Ser Arg Ala Arg Arg Ser Leu Ala Ser Pro Gly Ile
              20                  25                  30        
 Ser Pro Gly Pro Leu Thr Ala Thr Ile Gly Gly Ala Val Ala Gly Gly
          35                  40                  45            
 Gly Pro Arg Gln Gly Arg Ala Glu Ala His Lys Glu Val Phe Pro Gly
      50                  55                  60                
 Gln Arg Val Gly Lys Met Ala Ala Pro Met Glu Leu Phe Cys Trp Ser
  65                  70                  75                  80
 Gly Gly Trp Gly Leu Pro Ser Val Asp Leu Asp Ser Leu Ala Val Leu
                  85                  90                  95    
 Thr Tyr Ala Arg Phe Thr Gly Ala Pro Leu Lys Val His Lys Ile Ser
             100                 105                 110        
 Asn Pro Trp Gln Ser Pro Ser Gly Thr Leu Pro Ala Leu Arg Thr Ser
         115                 120                 125            
 His Gly Glu Val Ile Ser Val Pro His Lys Ile Ile Thr His Leu Arg
     130                 135                 140                
 Lys Glu Lys Tyr Asn Ala Asp Tyr Asp Leu Ser Ala Arg Gln Gly Ala
 145                 150                 155                 160
 Asp Thr Leu Ala Phe Met Ser Leu Leu Glu Glu Lys Leu Leu Pro Val
                 165                 170                 175    
 Leu Val His Thr Phe Trp Ile Asp Thr Lys Asn Tyr Val Glu Val Thr
             180                 185                 190        
 Arg Lys Trp Tyr Ala Glu Ala Met Pro Phe Pro Leu Asn Phe Phe Leu
         195                 200                 205            
 Pro Gly Arg Met Gln Arg Gln Tyr Met Glu Arg Leu Gln Leu Leu Thr
     210                 215                 220                
 Gly Glu His Arg Pro Glu Asp Glu Glu Glu Leu Glu Lys Glu Leu Tyr
 225                 230                 235                 240
 Arg Glu Ala Arg Glu Cys Leu Thr Leu Leu Ser Gln Arg Leu Gly Ser
                 245                 250                 255    
 Gln Lys Phe Phe Phe Gly Asp Ala Pro Ala Ser Leu Asp Ala Phe Val
             260                 265                 270        
 Phe Ser Tyr Leu Ala Leu Leu Leu Gln Ala Lys Leu Pro Ser Gly Lys
         275                 280                 285            
 Leu Gln Val His Leu Arg Gly Leu His Asn Leu Cys Ala Tyr Cys Thr
     290                 295                 300                
 His Ile Leu Ser Leu Tyr Phe Pro Trp Asp Gly Ala Glu Val Pro Pro
 305                 310                 315                 320
 Gln Arg Gln Thr Pro Ala Gly Pro Glu Thr Glu Glu Glu Pro Tyr Arg
                 325                 330                 335    
 Arg Arg Asn Gln Ile Leu Ser Val Leu Ala Gly Leu Ala Ala Met Val
             340                 345                 350        
 Gly Tyr Ala Leu Leu Ser Gly Ile Val Ser Ile Gln Arg Ala Thr Pro
         355                 360                 365            
 Ala Arg Ala Pro Gly Thr Arg Thr Leu Gly Met Ala Glu Glu Asp Glu
     370                 375                 380                
 Glu Glu
 385    



      <210> 421
      <211> 546
      <212> PRT
      <213> Homo sapiens


      <400> 421
 Met Phe Thr Ala Asp Met Arg Glu Arg Asp Gln Asp Lys Ile His Leu
   1               5                  10                  15    
 Lys Gly Leu Thr Ala Thr Gly Phe Ser His Val Leu Gln Phe Met Tyr
              20                  25                  30        
 Tyr Gly Thr Ile Glu Leu Ser Met Asn Thr Val His Glu Ile Leu Gln
          35                  40                  45            
 Ala Ala Met Tyr Val Gln Leu Ile Glu Val Val Lys Phe Cys Cys Ser
      50                  55                  60                
 Phe Leu Leu Ala Lys Ile Cys Leu Glu Asn Cys Ala Glu Ile Met Arg
  65                  70                  75                  80
 Leu Leu Asp Asp Phe Gly Val Asn Ile Glu Gly Val Arg Glu Lys Leu
                  85                  90                  95    
 Asp Thr Phe Leu Leu Asp Asn Phe Val Pro Leu Met Ser Arg Pro Asp
             100                 105                 110        
 Phe Leu Ser Tyr Leu Ser Phe Glu Lys Leu Met Ser Tyr Leu Asp Asn
         115                 120                 125            
 Asp His Leu Ser Arg Phe Pro Glu Ile Glu Leu Tyr Glu Ala Val Gln
     130                 135                 140                
 Ser Trp Leu Arg His Asp Arg Arg Arg Trp Arg His Thr Asp Thr Ile
 145                 150                 155                 160
 Ile Gln Asn Ile Arg Phe Cys Leu Met Thr Pro Thr Ser Val Phe Glu
                 165                 170                 175    
 Lys Val Lys Thr Ser Glu Phe Tyr Arg Tyr Ser Arg Gln Leu Arg Tyr
             180                 185                 190        
 Glu Val Asp Gln Ala Leu Asn Tyr Phe Gln Asn Val His Gln Gln Pro
         195                 200                 205            
 Leu Leu Asp Met Lys Ser Ser Arg Ile Arg Ser Ala Lys Pro Gln Thr
     210                 215                 220                
 Thr Val Phe Arg Gly Met Ile Gly His Ser Met Val Asn Ser Lys Ile
 225                 230                 235                 240
 Leu Leu Leu Lys Lys Pro Arg Val Trp Trp Glu Leu Glu Gly Pro Gln
                 245                 250                 255    
 Val Pro Leu Arg Pro Asp Cys Leu Ala Ile Val Asn Asn Phe Val Phe
             260                 265                 270        
 Leu Leu Gly Gly Glu Glu Leu Gly Pro Asp Gly Glu Phe His Ala Ser
         275                 280                 285            
 Ser Lys Val Phe Arg Tyr Asp Pro Arg Gln Asn Ser Trp Leu Gln Met
     290                 295                 300                
 Ala Asp Met Ser Val Pro Arg Ser Glu Phe Ala Val Gly Val Ile Gly
 305                 310                 315                 320
 Lys Phe Ile Tyr Ala Val Ala Gly Arg Thr Arg Asp Glu Thr Phe Tyr
                 325                 330                 335    
 Ser Thr Glu Arg Tyr Asp Ile Thr Asn Asp Lys Trp Glu Phe Val Asp
             340                 345                 350        
 Pro Tyr Pro Val Asn Lys Tyr Gly His Glu Gly Thr Val Leu Asn Asn
         355                 360                 365            
 Lys Leu Phe Ile Thr Gly Gly Ile Thr Ser Ser Ser Thr Ser Lys Gln
     370                 375                 380                
 Val Cys Val Phe Asp Pro Ser Lys Glu Gly Thr Ile Glu Gln Arg Thr
 385                 390                 395                 400
 Arg Arg Thr Gln Val Val Thr Asn Cys Trp Glu Asn Lys Ser Lys Met
                 405                 410                 415    
 Asn Tyr Ala Arg Cys Phe His Lys Met Ile Ser Tyr Asn Gly Lys Leu
             420                 425                 430        
 Tyr Val Phe Gly Gly Val Cys Val Ile Leu Arg Ala Ser Phe Glu Ser
         435                 440                 445            
 Gln Gly Cys Pro Ser Thr Glu Val Tyr Asn Pro Glu Thr Asp Gln Trp
     450                 455                 460                
 Thr Ile Leu Ala Ser Met Pro Ile Gly Arg Ser Gly His Gly Val Thr
 465                 470                 475                 480
 Val Leu Asp Lys Gln Ile Met Val Leu Gly Gly Leu Cys Tyr Asn Gly
                 485                 490                 495    
 His Tyr Ser Asp Ser Ile Leu Thr Phe Asp Pro Asp Glu Asn Lys Trp
             500                 505                 510        
 Lys Glu Asp Glu Tyr Pro Arg Met Pro Cys Lys Leu Asp Gly Leu Gln
         515                 520                 525            
 Val Cys Asn Leu His Phe Pro Asp Tyr Val Leu Asp Glu Val Arg Arg
     530                 535                 540                
 Cys Asn
 545    



      <210> 422
      <211> 601
      <212> PRT
      <213> Homo sapiens


      <400> 422
 Met Glu Lys Ile Glu Glu Gln Phe Ala Asn Leu His Ile Val Lys Cys
   1               5                  10                  15    
 Ser Leu Gly Thr Lys Glu Pro Thr Tyr Leu Leu Gly Ile Asp Thr Ser
              20                  25                  30        
 Lys Thr Val Gln Ala Gly Lys Glu Asn Leu Val Ala Val Leu Cys Ser
          35                  40                  45            
 Asn Gly Ser Ile Arg Ile Tyr Asp Lys Glu Arg Leu Asn Val Leu Arg
      50                  55                  60                
 Glu Phe Ser Gly Tyr Pro Gly Leu Leu Asn Gly Val Arg Phe Ala Asn
  65                  70                  75                  80
 Ser Cys Asp Ser Val Tyr Ser Ala Cys Thr Asp Gly Thr Val Lys Cys
                  85                  90                  95    
 Trp Asp Ala Arg Val Ala Arg Glu Lys Pro Val Gln Leu Phe Lys Gly
             100                 105                 110        
 Tyr Pro Ser Asn Ile Phe Ile Ser Phe Asp Ile Asn Cys Asn Asp His
         115                 120                 125            
 Ile Ile Cys Ala Gly Thr Glu Lys Val Asp Asp Asp Ala Leu Leu Val
     130                 135                 140                
 Phe Trp Asp Ala Arg Met Asn Ser Gln Asn Leu Ser Thr Thr Lys Asp
 145                 150                 155                 160
 Ser Leu Gly Ala Tyr Ser Glu Thr His Ser Asp Asp Val Thr Gln Val
                 165                 170                 175    
 Arg Phe His Pro Ser Asn Pro Asn Met Val Val Ser Gly Ser Ser Asp
             180                 185                 190        
 Gly Leu Val Asn Val Phe Asp Ile Asn Ile Asp Asn Glu Glu Asp Ala
         195                 200                 205            
 Leu Val Thr Thr Cys Asn Ser Ile Ser Ser Val Ser Cys Ile Gly Trp
     210                 215                 220                
 Ser Gly Lys Gly Tyr Lys Gln Ile Tyr Cys Met Thr His Asp Glu Gly
 225                 230                 235                 240
 Phe Tyr Trp Trp Asp Leu Asn His Leu Asp Thr Asp Glu Pro Val Thr
                 245                 250                 255    
 Arg Leu Asn Ile Gln Asp Val Arg Glu Val Val Asn Met Lys Glu Asp
             260                 265                 270        
 Ala Leu Asp Tyr Leu Ile Gly Gly Leu Tyr His Glu Lys Thr Asp Thr
         275                 280                 285            
 Leu His Val Ile Gly Gly Thr Asn Lys Gly Arg Ile His Leu Met Asn
     290                 295                 300                
 Cys Ser Met Ser Gly Leu Thr His Val Thr Ser Leu Gln Gly Gly His
 305                 310                 315                 320
 Ala Ala Thr Val Arg Ser Phe Cys Trp Asn Val Gln Asp Asp Ser Leu
                 325                 330                 335    
 Leu Thr Gly Gly Glu Asp Ala Gln Leu Leu Leu Trp Lys Pro Gly Ala
             340                 345                 350        
 Ile Glu Lys Thr Phe Thr Lys Lys Glu Ser Met Lys Ile Ala Ser Ser
         355                 360                 365            
 Val His Gln Arg Val Arg Val His Ser Asn Asp Ser Tyr Lys Arg Arg
     370                 375                 380                
 Lys Lys Gln Leu Phe Gly Ala Gly Leu Ser Ser Val Arg Phe Ile Arg
 385                 390                 395                 400
 Gly Thr Gln Ser Ile His Lys Asn Leu Glu Ala Lys Ile Ala Arg Phe
                 405                 410                 415    
 His Gln Arg Glu Asp Ala Ile Leu Tyr Pro Ser Cys Cys Asp Ala Asn
             420                 425                 430        
 Ala Gly Leu Phe Glu Val Leu Leu Arg Pro Glu Asp Ala Val Leu Ser
         435                 440                 445            
 Asp Glu Leu Asn Cys Ala Ser Ile Ile His Gly Ile Cys Leu Cys Lys
     450                 455                 460                
 Ala His Lys Tyr His Tyr Cys His Leu Asp Val Ala Tyr Leu Glu Thr
 465                 470                 475                 480
 Lys Leu Gln Glu Ala Gln Lys His Arg Leu Phe Leu Val Ala Thr Asp
                 485                 490                 495    
 Gly Ala Phe Ser Met Asp Gly Asp Ile Val Pro Leu Gln Lys Ile Cys
             500                 505                 510        
 Arg Leu Ala Ser Arg Tyr Gly Ala Leu Val Phe Val Asp Glu Cys His
         515                 520                 525            
 Ala Thr Gly Phe Leu Gly Leu Thr Gly Gln Gly Thr Asp Glu Leu Leu
     530                 535                 540                
 Gly Val Met Gly Gln Val Thr Ile Ile Asn Ser Thr Leu Gly Lys Ala
 545                 550                 555                 560
 Leu Gly Gly Ala Ser Gly Gly Tyr Thr Thr Gly Pro Gly Pro Leu Val
                 565                 570                 575    
 Ser Leu Leu Leu Pro Ser Pro Ile Ser Ser Pro Thr Val Cys His Leu
             580                 585                 590        
 Leu Leu Leu Ala Ala Pro Leu Arg Pro
         595                 600    



      <210> 423
      <211> 1668
      <212> PRT
      <213> Homo sapiens


      <400> 423
 Met Ala Val Glu Gly Asp His Ser Met Cys Pro Pro Pro Pro Ile Arg
   1               5                  10                  15    
 Asn Glu Gln Pro Val Leu Val Leu Ala Gln Trp Leu Pro Ser Leu Pro
              20                  25                  30        
 Thr Ala Glu Leu Arg Leu Phe Leu Ala Gln Arg Leu Arg Trp Leu Cys
          35                  40                  45            
 Asp Ser Cys Pro Ala Ser Arg Ala Thr Cys Val Gln Ala Gly Leu Val
      50                  55                  60                
 Gly Cys Leu Leu Glu Thr Leu Ser Thr Gly Leu Ala Leu Glu Ala Arg
  65                  70                  75                  80
 Cys Gln Glu Gln Leu Leu Ala Leu Leu Gln Ala Leu Gly Arg Val Ser
                  85                  90                  95    
 Ile Arg Pro Met Glu Leu Arg His Leu Leu Arg Pro Arg Pro Gly Leu
             100                 105                 110        
 Asp Ser Glu Pro Gly Gly Ala Glu Ala Gly Lys Ala Arg His Ala Gly
         115                 120                 125            
 Ala Val Ile Arg Thr Leu Ser Gly Met Ala Arg His Gln Gly Pro Ala
     130                 135                 140                
 Arg Ala Leu Arg Tyr Phe Asp Leu Thr Pro Ser Met Ala Gly Ile Met
 145                 150                 155                 160
 Val Pro Pro Val Gln Arg Trp Pro Gly Pro Gly Phe Thr Phe His Ala
                 165                 170                 175    
 Trp Leu Cys Leu His Pro Met Asp Thr Ala Pro Thr Pro Ala Pro Thr
             180                 185                 190        
 Arg Pro Leu Gln Arg Lys Gln Leu Tyr Ser Phe Phe Thr Ser Ser Gly
         195                 200                 205            
 Ser Gly Phe Glu Ala Phe Phe Thr Ala Ala Gly Thr Leu Val Val Ala
     210                 215                 220                
 Val Cys Thr Arg Lys Glu Tyr Leu Thr Met Ser Leu Pro Glu Val Ser
 225                 230                 235                 240
 Phe Ala Asp Ser Ala Trp His Cys Val Ala Ile Val His Val Pro Gly
                 245                 250                 255    
 Arg Arg Pro Phe Ser Gln Asn Leu Val His Val Tyr Lys Asp Gly His
             260                 265                 270        
 Leu Val Lys Thr Ala Pro Leu Arg Cys Pro Ser Leu Ser Glu Pro Phe
         275                 280                 285            
 Ser Ser Cys Cys Ile Gly Ser Ala Gly Tyr Arg Thr Thr Thr Thr Thr
     290                 295                 300                
 Thr Gly Leu Pro Thr Pro Pro Val Pro Ala Thr Leu Ala Tyr Thr His
 305                 310                 315                 320
 Pro Ala Leu Thr Arg Ser Gln Ser Val Pro Ala Ser Thr Gly Leu Gly
                 325                 330                 335    
 Trp Gly Ser Gly Leu Val Ala Pro Leu Gln Glu Gly Ser Ile Asp Ser
             340                 345                 350        
 Thr Leu Ala Gly Thr Gln Asp Thr Arg Trp Gly Ser Pro Thr Ser Leu
         355                 360                 365            
 Glu Gly Glu Leu Gly Ala Val Ala Ile Phe His Glu Ala Leu Gln Ala
     370                 375                 380                
 Thr Ala Leu Arg Thr Leu Cys Thr Leu Gly Pro Asn Glu Thr Ala Pro
 385                 390                 395                 400
 Phe Lys Pro Glu Gly Glu Leu His Glu Leu Ser Thr Arg Leu Leu Leu
                 405                 410                 415    
 His Tyr Ser Pro His Ala Cys Lys Asn Asn Ile Cys Leu Asp Leu Ser
             420                 425                 430        
 Pro Ser His Gly Leu Asp Gly Arg Leu Thr Gly His Arg Val Glu Thr
         435                 440                 445            
 Trp Asp Val Lys Asp Val Val Asn Cys Val Gly Gly Met Gly Ala Leu
     450                 455                 460                
 Leu Pro Leu Leu Glu Arg Val Ala Ala Gln Pro Lys Glu Ala Glu Ala
 465                 470                 475                 480
 Gly Pro Ala Glu Thr His Asp Leu Val Gly Pro Glu Leu Thr Ser Gly
                 485                 490                 495    
 His Asn Thr Gln Gly Leu Val Leu Pro Leu Gly Lys Ser Ser Glu Glu
             500                 505                 510        
 Arg Met Glu Arg Asn Ala Val Ala Ala Phe Leu Leu Met Leu Arg Asn
         515                 520                 525            
 Phe Leu Gln Gly His Met Val Asn Gln Glu Ser Leu Val Gln Cys Gln
     530                 535                 540                
 Gly Pro Ala Ile Ile Gly Ala Leu Leu Arg Lys Val Pro Ser Trp Ala
 545                 550                 555                 560
 Met Asp Met Asn Val Leu Met Ser Ala Gln Leu Leu Met Glu Gln Val
                 565                 570                 575    
 Ala Ala Glu Gly Ser Gly Pro Leu Leu Tyr Leu Leu Tyr Gln His Leu
             580                 585                 590        
 Leu Phe Asn Phe His Leu Trp Thr Leu Ser Asp Phe Ala Val Arg Leu
         595                 600                 605            
 Gly His Ile Gln Tyr Met Ser Ser Ile Val Arg Glu His Arg Gln Lys
     610                 615                 620                
 Leu Arg Lys Lys Tyr Gly Val Gln Phe Ile Leu Asp Ala Leu Arg Thr
 625                 630                 635                 640
 His Tyr Ser Pro Gln Arg Glu Arg Pro Leu Ala Ala Asp Asp Leu Arg
                 645                 650                 655    
 Thr Val Gln Thr Ser Leu Leu Gly Leu Ala Arg Glu Phe Leu Val Arg
             660                 665                 670        
 Ser Leu Ser Ala Asp Asp Val Gln Val Thr Gln Thr Met Leu Ser Phe
         675                 680                 685            
 Leu Ala Ala Thr Gly Asp Asp Gly Gln Ala Val Gly Ala Leu Asp Leu
     690                 695                 700                
 Leu Leu Ala Leu Leu His Gly Ser Leu Val Gln Glu Ser Leu Ala Val
 705                 710                 715                 720
 Phe Leu Leu Glu Pro Gly Asn Leu Glu Val Leu Leu Ala Leu Leu Val
                 725                 730                 735    
 Arg Pro Gly Ser Leu Pro Leu Leu Pro Asp Arg Val Cys Lys Ile Leu
             740                 745                 750        
 Arg Arg Leu Gln Gln Asn Glu Arg Leu Pro Glu Arg Ser Arg Gln Arg
         755                 760                 765            
 Leu Arg Leu Arg Glu Cys Gly Leu Gln Gly Leu Val Ala Cys Leu Pro
     770                 775                 780                
 Glu Gly Thr Val Ser Pro Gln Leu Cys Gln Gly Leu Tyr Lys Leu Phe
 785                 790                 795                 800
 Leu Gly Ala Asp Cys Leu Asn Leu Ser Asp Leu Leu Ala Val Val Gln
                 805                 810                 815    
 Leu Ser Leu Gln Ala Asp Leu Ser Val Arg Leu Asp Ile Cys Arg Gln
             820                 825                 830        
 Leu Phe His Leu Ile Tyr Gly Gln Pro Asp Val Val Arg Leu Leu Ala
         835                 840                 845            
 Arg Gln Ala Gly Trp Gln Asp Val Leu Thr Arg Leu Tyr Val Leu Glu
     850                 855                 860                
 Ala Ala Thr Ala Gly Ser Pro Pro Pro Ser Ser Pro Glu Ser Pro Thr
 865                 870                 875                 880
 Ser Pro Lys Pro Ala Pro Pro Lys Pro Pro Thr Glu Ser Pro Ala Glu
                 885                 890                 895    
 Pro Ser Asp Val Phe Leu Pro Ser Glu Ala Pro Cys Pro Asp Pro Asp
             900                 905                 910        
 Gly Phe Tyr His Ala Leu Ser Pro Phe Cys Thr Pro Phe Asp Leu Gly
         915                 920                 925            
 Leu Glu Arg Ser Ser Val Gly Ser Gly Asn Thr Ala Gly Gly Gly Gly
     930                 935                 940                
 Ser Ser Gly Thr Leu Thr Pro Ala Ser Gln Pro Gly Thr Pro Ser Pro
 945                 950                 955                 960
 Leu Asp Gly Pro Arg Pro Phe Pro Ala Ala Pro Gly Arg His Ser Ser
                 965                 970                 975    
 Ser Leu Ser Asn Val Leu Glu Asp Gly Ser Leu Pro Glu Pro Thr Ile
             980                 985                 990        
 Ser Gly Asp Asp Thr Ser Asn Thr Ser Asn Pro Gln Gln Thr Ser Glu
         995                1000                1005            
 Glu Glu Leu Cys Asn Leu Leu Thr Asn Val Leu Phe Ser Val Thr Trp
    1010                1015                1020                
 Arg Gly Val Glu Gly Ser Asp Glu Ala Ala Trp Arg Glu Arg Gly Gln
1025                1030                1035                1040
 Val Phe Ser Val Leu Thr Gln Leu Gly Ala Ser Ala Thr Leu Val Arg
                1045                1050                1055    
 Pro Pro Asp Cys Ile Lys Arg Ser Leu Leu Glu Met Met Leu Glu Ser
            1060                1065                1070        
 Ala Leu Thr Asp Ile Lys Glu Ala Pro Val Gly Val Leu Ala Ser Leu
        1075                1080                1085            
 Thr Gln Gln Ala Leu Trp Leu Leu Arg Leu Leu Gln Asp Phe Leu Cys
    1090                1095                1100                
 Ala Glu Gly His Gly Asn Gln Glu Leu Trp Ser Glu Lys Leu Phe Glu
1105                1110                1115                1120
 Gly Val Cys Ser Leu Leu Asp Arg Leu Gly Ala Trp Pro His Leu Ala
                1125                1130                1135    
 Asn Gly Thr Ala Asp Leu Arg Glu Met Ala Gln Ile Gly Leu Arg Leu
            1140                1145                1150        
 Val Leu Gly Tyr Ile Leu Leu Glu Asp Pro Gln Leu His Ala Gln Ala
        1155                1160                1165            
 Tyr Val Arg Leu His Met Leu Leu Gln Thr Ala Val Pro Ala Arg Arg
    1170                1175                1180                
 Glu Glu Ala Cys Tyr Val Leu Ser Lys Leu Glu Ala Ala Leu Gly Arg
1185                1190                1195                1200
 Val Leu Asn Thr Ser Ser Leu Glu Ser Ala Thr Asp Glu Ala Gly Ser
                1205                1210                1215    
 Pro Leu Ala Ala Ala Ala Ala Ala Ala Ala Ala Glu Arg Cys Ser Trp
            1220                1225                1230        
 Leu Val Pro Leu Val Arg Thr Leu Leu Asp Arg Ala Tyr Glu Pro Leu
        1235                1240                1245            
 Gly Leu Gln Trp Gly Leu Pro Ser Leu Pro Pro Thr Asn Gly Ser Pro
    1250                1255                1260                
 Thr Phe Phe Glu Asp Phe Gln Ala Phe Cys Ala Thr Pro Glu Trp Arg
1265                1270                1275                1280
 His Phe Ile Asp Lys Gln Val Gln Pro Thr Met Ser Gln Phe Glu Met
                1285                1290                1295    
 Asp Thr Tyr Ala Lys Ser His Asp Leu Met Ser Gly Phe Trp Asn Ala
            1300                1305                1310        
 Cys Tyr Asp Met Leu Met Ser Ser Gly Gln Arg Arg Gln Trp Glu Arg
        1315                1320                1325            
 Ala Gln Ser Arg Arg Ala Phe Gln Glu Leu Val Leu Glu Pro Ala Gln
    1330                1335                1340                
 Arg Arg Ala Arg Leu Glu Gly Leu Arg Tyr Thr Ala Val Leu Lys Gln
1345                1350                1355                1360
 Gln Ala Thr Gln His Ser Met Ala Leu Leu His Trp Gly Ala Leu Trp
                1365                1370                1375    
 Arg Gln Leu Ala Ser Pro Cys Gly Ala Trp Ala Leu Arg Asp Thr Pro
            1380                1385                1390        
 Ile Pro Arg Trp Lys Leu Ser Ser Ala Glu Thr Tyr Ser Arg Met Arg
        1395                1400                1405            
 Leu Lys Leu Val Pro Asn His His Phe Asp Pro His Leu Glu Ala Ser
    1410                1415                1420                
 Ala Leu Arg Asp Asn Leu Gly Glu Val Pro Leu Thr Pro Thr Glu Glu
1425                1430                1435                1440
 Ala Ser Leu Pro Leu Ala Val Thr Lys Glu Ala Lys Val Ser Thr Pro
                1445                1450                1455    
 Pro Glu Leu Leu Gln Glu Asp Gln Leu Gly Glu Asp Glu Leu Ala Glu
            1460                1465                1470        
 Leu Glu Thr Pro Met Glu Ala Ala Glu Leu Asp Glu Gln Arg Glu Lys
        1475                1480                1485            
 Leu Val Leu Ser Ala Glu Cys Gln Leu Val Thr Val Val Ala Val Val
    1490                1495                1500                
 Pro Gly Leu Leu Glu Val Thr Thr Gln Asn Val Tyr Phe Tyr Asp Gly
1505                1510                1515                1520
 Ser Thr Glu Arg Val Glu Thr Glu Glu Gly Ile Gly Tyr Asp Phe Arg
                1525                1530                1535    
 Arg Pro Leu Ala Gln Leu Arg Glu Val His Leu Arg Arg Phe Asn Leu
            1540                1545                1550        
 Arg Arg Ser Ala Leu Glu Leu Phe Phe Ile Asp Gln Ala Asn Tyr Phe
        1555                1560                1565            
 Leu Asn Phe Pro Cys Lys Val Gly Thr Thr Pro Val Ser Ser Pro Ser
    1570                1575                1580                
 Gln Thr Pro Arg Pro Gln Pro Gly Pro Ile Pro Pro His Thr Gln Val
1585                1590                1595                1600
 Arg Asn Gln Val Tyr Ser Trp Leu Leu Arg Leu Arg Pro Pro Ser Gln
                1605                1610                1615    
 Gly Tyr Leu Ser Ser Arg Ser Pro Gln Glu Met Leu Arg Ala Ser Gly
            1620                1625                1630        
 Leu Thr Gln Lys Trp Val Gln Arg Glu Ile Ser Asn Phe Glu Tyr Leu
        1635                1640                1645            
 Met Gln Leu Asn Thr Ile Ala Gly Arg Thr Tyr Asn Asp Leu Ser Gln
    1650                1655                1660                
 Tyr Pro Val Val
1665            



      <210> 424
      <211> 434
      <212> PRT
      <213> Homo sapiens


      <400> 424
 Met Glu Pro Arg Val Val Lys Pro Pro Gly Gln Asp Leu Val Val Glu
   1               5                  10                  15    
 Ser Leu Lys Ser Arg Tyr Gly Leu Gly Gly Ser Cys Pro Asp Glu Tyr
              20                  25                  30        
 Asp Phe Ser Asn Phe Tyr Gln Ser Lys Tyr Lys Arg Arg Thr Leu Thr
          35                  40                  45            
 Ser Pro Gly Asp Leu Asp Ile Tyr Ser Gly Asp Lys Val Gly Ser Ser
      50                  55                  60                
 Leu Lys Tyr Ser Asp Glu Ser Lys His Cys Arg Thr Pro Leu Gly Ser
  65                  70                  75                  80
 Leu Phe Lys His Val Asn Val Asn Cys Leu Asp Asp Glu Leu Asp Ser
                  85                  90                  95    
 Phe His Asp Leu Lys Lys Gln Glu Thr Glu Glu Glu Leu Ile Glu Asn
             100                 105                 110        
 Asp Tyr Arg Val Ser Thr Ser Lys Ile Thr Lys Gln Ser Phe Lys Glu
         115                 120                 125            
 Ile Glu Lys Val Ala Leu Pro Thr Asn Thr Thr Ser Ser Arg Pro Arg
     130                 135                 140                
 Thr Glu Cys Cys Ser Asp Ala Gly Asp Ser Pro Leu Lys Pro Val Ser
 145                 150                 155                 160
 Cys Pro Lys Ser Lys Ala Ser Asp Lys Arg Ser Leu Leu Pro His Gln
                 165                 170                 175    
 Ile Ser Gln Ile Tyr Asp Glu Leu Phe Gln Ile His Leu Lys Leu Gln
             180                 185                 190        
 Cys Glu Thr Ala Ala Gln Gln Lys Phe Ala Glu Glu Leu Gln Lys Arg
         195                 200                 205            
 Glu Arg Phe Leu Leu Glu Arg Glu Gln Leu Leu Phe Arg His Glu Asn
     210                 215                 220                
 Ala Leu Ser Lys Ile Lys Gly Val Glu Glu Glu Val Leu Thr Arg Phe
 225                 230                 235                 240
 Gln Ile Ile Lys Glu Gln His Asp Ala Glu Val Glu His Leu Thr Glu
                 245                 250                 255    
 Val Leu Lys Glu Lys Asn Lys Glu Thr Lys Arg Leu Arg Ser Ser Phe
             260                 265                 270        
 Asp Ala Leu Lys Glu Leu Asn Asp Thr Leu Lys Lys Gln Leu Asn Glu
         275                 280                 285            
 Ala Ser Glu Glu Asn Arg Lys Ile Asp Ile Gln Ala Lys Arg Val Gln
     290                 295                 300                
 Ala Arg Leu Asp Asn Leu Gln Arg Lys Tyr Glu Phe Met Thr Ile Gln
 305                 310                 315                 320
 Arg Leu Lys Gly Ser Ser His Ala Val His Glu Met Lys Ser Leu Lys
                 325                 330                 335    
 Gln Glu Lys Ala Pro Val Ser Lys Thr Tyr Lys Val Pro Leu Asn Gly
             340                 345                 350        
 Gln Val Tyr Glu Leu Leu Thr Val Phe Met Asp Trp Ile Ser Asp His
         355                 360                 365            
 His Leu Ser Lys Val Lys His Glu Glu Ser Gly Met Asp Gly Lys Lys
     370                 375                 380                
 Pro Gln Leu Lys Phe Ala Ser Gln Arg Asn Asp Ile Gln Glu Lys Cys
 385                 390                 395                 400
 Val Lys Asn Pro Cys Ser Leu Ser Trp Lys Pro Val Ala Thr Leu Tyr
                 405                 410                 415    
 Phe Phe Val Leu Ala Leu Cys Cys Phe Glu Pro Leu Ser Leu Ile Phe
             420                 425                 430        
 Lys Tyr
        



      <210> 425
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 425
 Met Gly Arg Lys Asp Ala Ala Thr Ile Lys Leu Pro Val Asp Gln Tyr
   1               5                  10                  15    
 Arg Lys Gln Ile Gly Lys Gln Asp Tyr Lys Lys Thr Lys Pro Ile Leu
              20                  25                  30        
 Arg Ala Thr Lys Leu Lys Ala Glu Ala Lys Lys Thr Ala Ile Gly Ile
          35                  40                  45            
 Lys Glu Val Gly Leu Val Leu Ala Ala Ile Leu Ala Leu Leu Leu Ala
      50                  55                  60                
 Phe Tyr Ala Phe Phe Tyr Leu Arg Leu Thr Thr Asp Val Asp Pro Asp
  65                  70                  75                  80
 Leu Asp Gln Asp Glu Asp
                  85    



      <210> 426
      <211> 163
      <212> PRT
      <213> Homo sapiens


      <400> 426
 Met Thr Asp Gln Thr Tyr Cys Asp Arg Leu Val Gln Asp Thr Pro Phe
   1               5                  10                  15    
 Leu Thr Gly His Gly Arg Leu Ser Glu Gln Gln Val Asp Arg Ile Ile
              20                  25                  30        
 Leu Gln Leu Asn Arg Tyr Tyr Pro Gln Ile Leu Thr Asn Lys Glu Ala
          35                  40                  45            
 Glu Lys Phe Arg Asn Pro Lys Ala Ser Leu Arg Val Arg Leu Cys Asp
      50                  55                  60                
 Leu Leu Ser His Leu Gln Arg Ser Gly Glu Arg Asp Cys Gln Glu Phe
  65                  70                  75                  80
 Tyr Arg Ala Leu Tyr Ile His Ala Gln Pro Leu His Ser Arg Leu Pro
                  85                  90                  95    
 Ser Arg His Ala Leu Arg Pro Met Ser Phe Leu Ala Gly Leu Gly Leu
             100                 105                 110        
 Ala Val Gly Leu Ala Leu Leu Leu Tyr Cys Tyr Pro Pro Asp Pro Lys
         115                 120                 125            
 Gly Leu Pro Gly Thr Arg Arg Val Leu Gly Phe Ser Pro Val Ile Ile
     130                 135                 140                
 Asp Arg His Val Ser Arg Tyr Leu Leu Ala Phe Leu Ala Asp Asp Leu
 145                 150                 155                 160
 Gly Gly Leu
            



      <210> 427
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 427
 Met Pro Ala Pro His Gly Leu Ala Ala Arg Ala Thr Ser Leu Ser Gly
   1               5                  10                  15    
 Arg Ala Val Ala Glu Ser Trp His Gln Ser Gln Pro Cys Ser Pro Ser
              20                  25                  30        
 Leu Pro Arg Gly Ser Ala Tyr Ala Asn Ile Ile Ser Gln Phe Ala Gln
          35                  40                  45            
 Thr Val Phe Leu Leu Leu Tyr Ile Val Leu Lys Lys Leu His Leu Glu
      50                  55                  60                
 Thr Trp Ala Gly Trp Ser Ser Gln Cys Leu Gln Asp Trp Gly Pro Phe
  65                  70                  75                  80
 Phe Ser Leu Ala Val Pro Ser Met Leu Met Ile Cys Val Glu Trp Trp
                  85                  90                  95    
 Ala Tyr Glu Ile Gly Ser Phe Leu Met Gly Leu Leu Ser Val Val Asp
             100                 105                 110        
 Leu Ser Ala Gln Ala Val Ile Tyr Glu Val Ala Thr Val Thr Tyr Met
         115                 120                 125            
 Ile Pro Leu Gly Leu Ser Ile Gly Val Cys Val Arg Val Gly Met Ala
     130                 135                 140                
 Leu Gly Ala Ala Asp Thr Val Gln Ala Lys Arg Ser Ala Val Ser Gly
 145                 150                 155                 160
 Val Leu Ser Ile Val Gly Ile Ser Leu Val Leu Gly Thr Leu Ile Ser
                 165                 170                 175    
 Ile Leu Lys Asn Gln Leu Gly His Ile Phe Thr Asn Asp Glu Asp Val
             180                 185                 190        
 Ile Ala Leu Val Ser Gln Val Leu Pro Val Tyr Ser Val Phe His Val
         195                 200                 205            
 Phe Glu Ala Ile Cys Cys Val Tyr Gly Gly Val Leu Arg Gly Thr Gly
     210                 215                 220                
 Lys Gln Ala Phe Gly Ala Ala Val Asn Ala Ile Thr Tyr Tyr Ile Ile
 225                 230                 235                 240
 Gly Leu Pro Leu Gly Ile Leu Leu Thr Phe Val Val Arg Met Arg Ile
                 245                 250                 255    
 Met Gly Leu Trp Leu Gly Met Leu Ala Cys Val Phe Leu Ala Thr Ala
             260                 265                 270        
 Ala Phe Val Ala Tyr Thr Ala Arg Leu Asp Trp Lys Leu Ala Ala Glu
         275                 280                 285            
 Glu Ala Lys Lys His Ser Gly Arg Gln Gln Gln Gln Arg Ala Glu Ser
     290                 295                 300                
 Thr Ala Thr Arg Pro Gly Ala Ala Leu Gly Ala Ala Ser Ala Thr Leu
 305                 310                 315                 320
 Met Val Gly Leu Thr Val Arg Ile Leu Ala Thr Arg His
                 325                 330            



      <210> 428
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 428
 Met Pro Ala Pro His Gly Leu Ala Ala Arg Ala Thr Ser Leu Ser Gly
   1               5                  10                  15    
 Arg Ala Val Ala Glu Ser Trp His Gln Ser Gln Pro Cys Ser Pro Ser
              20                  25                  30        
 Leu Pro Arg Gly Ser Ala Tyr Ala Asn Ile Ile Ser Gln Phe Ala Gln
          35                  40                  45            
 Thr Val Phe Leu Leu Leu Tyr Ile Val Leu Lys Lys Leu His Leu Glu
      50                  55                  60                
 Thr Trp Ala Gly Trp Ser Ser Gln Cys Leu Gln Asp Trp Gly Pro Phe
  65                  70                  75                  80
 Phe Ser Leu Ala Val Pro Ser Met Leu Met Ile Cys Val Glu Trp Trp
                  85                  90                  95    
 Ala Tyr Glu Ile Gly Ser Phe Leu Met Gly Leu Leu Ser Val Val Asp
             100                 105                 110        
 Leu Ser Ala Gln Ala Val Ile Tyr Glu Val Ala Thr Val Thr Tyr Met
         115                 120                 125            
 Ile Pro Leu Gly Leu Ser Ile Gly Val Cys Val Arg Val Gly Met Ala
     130                 135                 140                
 Leu Gly Ala Ala Asp Thr Val Gln Ala Lys Arg Ser Ala Val Ser Gly
 145                 150                 155                 160
 Val Leu Ser Ile Val Gly Ile Ser Leu Val Leu Gly Thr Leu Ile Ser
                 165                 170                 175    
 Ile Leu Lys Asn Gln Leu Gly His Ile Phe Thr Asn Asp Glu Asp Val
             180                 185                 190        
 Ile Ala Leu Val Ser Gln Val Leu Pro Val Tyr Ser Val Phe His Val
         195                 200                 205            
 Phe Glu Ala Ile Cys Cys Val Tyr Gly Gly Val Leu Arg Gly Thr Gly
     210                 215                 220                
 Lys Gln Ala Phe Gly Ala Ala Val Asn Ala Ile Thr Tyr Tyr Ile Ile
 225                 230                 235                 240
 Gly Leu Pro Leu Gly Ile Leu Leu Thr Phe Val Val Arg Met Arg Ile
                 245                 250                 255    
 Met Gly Leu Trp Leu Gly Met Leu Ala Cys Val Phe Leu Ala Thr Ala
             260                 265                 270        
 Ala Phe Val Ala Tyr Thr Ala Arg Leu Asp Trp Lys Leu Ala Ala Glu
         275                 280                 285            
 Glu Ala Lys Lys His Ser Gly Arg Gln Gln Gln Gln Arg Ala Glu Ser
     290                 295                 300                
 Thr Ala Thr Arg Pro Gly Pro Glu Lys Ala Val Leu Ser Ser Val Ala
 305                 310                 315                 320
 Thr Gly Ser Ser Pro Gly Ile Thr Leu Thr Thr Tyr Ser Arg Ser Glu
                 325                 330                 335    
 Cys His Val Asp Phe Phe Arg Thr Pro Glu Glu Ala His Ala Leu Ser
             340                 345                 350        
 Ala Pro Thr Ser Arg Leu Ser Val Lys Gln Leu Val Ile Arg Arg Gly
         355                 360                 365            
 Ala Ala Leu Gly Ala Ala Ser Ala Thr Leu Met Val Gly Leu Thr Val
     370                 375                 380                
 Arg Ile Leu Ala Thr Arg His
 385                 390    



      <210> 429
      <211> 108
      <212> PRT
      <213> Homo sapiens


      <400> 429
 Met Glu Phe Leu Gln Ala Gly Thr His Thr Leu Gly His Val Ser Pro
   1               5                  10                  15    
 His Val Gln Gly Ser Leu Met Gln Ile Val Gly Asn Gln Val Trp Lys
              20                  25                  30        
 Phe Lys Asn Lys Arg His Glu Thr Lys Ala Ile Cys Phe Pro Tyr Ala
          35                  40                  45            
 Leu Thr Gly Glu Gly Arg Glu Glu Arg Gln Gly Pro Gln Arg Ala Ser
      50                  55                  60                
 Gln Leu Gly Leu Gly Met Ala Ala Val Arg Arg Asn Pro Gly Asn Cys
  65                  70                  75                  80
 Ile Asp Thr Lys Ile Leu Ile Ala Leu Val Phe Phe Val Leu Lys Phe
                  85                  90                  95    
 Ala Trp Phe Leu Ile Lys Asp Ser Asn Ile Ser Leu
             100                 105            



      <210> 430
      <211> 563
      <212> PRT
      <213> Homo sapiens


      <400> 430
 Met Glu Leu Arg Val Gly Asn Lys Tyr Arg Leu Gly Arg Lys Ile Gly
   1               5                  10                  15    
 Ser Gly Ser Phe Gly Asp Ile Tyr Leu Gly Ala Asn Ile Ala Ser Gly
              20                  25                  30        
 Glu Asp Val Ala Ile Lys Leu Glu Cys Val Lys Thr Lys His Pro Gln
          35                  40                  45            
 Leu His Ile Glu Ser Lys Phe Tyr Lys Met Met Gln Gly Gly Val Gly
      50                  55                  60                
 Ile Pro Ser Ile Lys Trp Cys Gly Ala Glu Gly Asp Tyr Asn Val Met
  65                  70                  75                  80
 Val Met Glu Leu Leu Gly Pro Ser Leu Glu Asp Leu Phe Asn Phe Cys
                  85                  90                  95    
 Ser Arg Lys Phe Ser Leu Lys Thr Val Leu Leu Leu Ala Asp Gln Met
             100                 105                 110        
 Ile Ser Arg Ile Glu Tyr Ile His Ser Lys Asn Phe Ile His Arg Asp
         115                 120                 125            
 Val Lys Pro Asp Asn Phe Leu Met Gly Leu Gly Lys Lys Gly Asn Leu
     130                 135                 140                
 Val Tyr Ile Ile Asp Phe Gly Leu Ala Lys Lys Tyr Arg Asp Ala Arg
 145                 150                 155                 160
 Thr His Gln His Ile Pro Tyr Arg Glu Asn Lys Asn Leu Thr Gly Thr
                 165                 170                 175    
 Ala Arg Tyr Ala Ser Ile Asn Thr His Leu Gly Ile Glu Gln Ser Arg
             180                 185                 190        
 Arg Asp Asp Leu Glu Ser Leu Gly Tyr Val Leu Met Tyr Phe Asn Leu
         195                 200                 205            
 Gly Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr Lys Arg Gln Lys
     210                 215                 220                
 Tyr Glu Arg Ile Ser Glu Lys Lys Met Ser Thr Pro Ile Glu Val Leu
 225                 230                 235                 240
 Cys Lys Gly Tyr Pro Ser Glu Phe Ser Thr Tyr Leu Asn Phe Cys Arg
                 245                 250                 255    
 Ser Leu Arg Phe Asp Asp Lys Pro Asp Tyr Ser Tyr Leu Arg Gln Leu
             260                 265                 270        
 Phe Arg Asn Leu Phe His Arg Gln Gly Phe Ser Tyr Asp Tyr Val Phe
         275                 280                 285            
 Asp Trp Asn Met Leu Lys Phe Val Ser His Leu Glu Ala Lys Ala Gly
     290                 295                 300                
 Leu Gly Asp Trp Met Gly Lys Ala Leu Thr Gln Arg Ala Arg Val Ser
 305                 310                 315                 320
 Trp Trp Arg Glu Gly Leu Pro Thr Asp Gly Arg Tyr Glu Leu Asp Ser
                 325                 330                 335    
 Val Val Asp Leu Thr Gly Val Pro Glu Pro Ser Ser Leu Ile Arg Ala
             340                 345                 350        
 Asp Ser Leu Cys His His Gly Gln Gln Gly Pro Gly Arg Ala Leu Ser
         355                 360                 365            
 Pro Val Gly Thr Arg Arg Ile Trp Leu His Leu Gly Ser Leu Leu Gly
     370                 375                 380                
 Ala Arg Ser Arg Ala Trp Val Val Leu Ala Ala Pro Pro Ala Ala Leu
 385                 390                 395                 400
 Ile Ala Ala Tyr Thr Val Leu Leu Leu Leu Phe Cys Thr Ser Gln Val
                 405                 410                 415    
 Ala Thr Cys Thr Met Ala Pro Arg Ala Ser Leu Asp Pro Val Met Val
             420                 425                 430        
 Leu Ala Phe Phe Leu Val Met Gly Pro Trp Gly Ala Ala Arg Asn Pro
         435                 440                 445            
 Glu Asp Val Asp Arg Glu Arg Arg Glu His Glu Arg Glu Glu Arg Met
     450                 455                 460                
 Gly Gln Leu Arg Gly Ser Ala Thr Arg Ala Leu Pro Pro Gly Pro Pro
 465                 470                 475                 480
 Thr Gly Ala Thr Ala Asn Arg Leu Arg Ser Ala Ala Glu Pro Val Ala
                 485                 490                 495    
 Ser Thr Pro Ala Ser Arg Ile Gln Pro Ala Gly Asn Thr Ser Pro Arg
             500                 505                 510        
 Ala Ile Ser Arg Val Asp Arg Glu Arg Lys Val Ser Met Arg Leu His
         515                 520                 525            
 Arg Gly Ala Pro Ala Asn Val Ser Ser Ser Asp Leu Thr Gly Arg Gln
     530                 535                 540                
 Glu Val Ser Arg Ile Pro Ala Ser Gln Thr Ser Val Pro Phe Asp His
 545                 550                 555                 560
 Leu Gly Lys
            



      <210> 431
      <211> 496
      <212> PRT
      <213> Homo sapiens


      <400> 431
 Met Phe Arg Gly Leu Asn Leu Ser Ser Gly Arg Val Leu Ala Arg Ser
   1               5                  10                  15    
 Glu Leu Pro Asp Pro Ala Lys His Leu Leu Phe Trp Ser Leu Lys Tyr
              20                  25                  30        
 Val Ile Met Ala Lys Phe Arg Arg Arg Thr Cys Ile Ile Leu Ala Leu
          35                  40                  45            
 Phe Ile Leu Phe Ile Phe Ser Leu Met Met Gly Leu Lys Met Leu Arg
      50                  55                  60                
 Pro Asn Thr Ala Thr Phe Gly Ala Pro Phe Gly Leu Asp Leu Leu Pro
  65                  70                  75                  80
 Glu Leu His Gln Arg Thr Ile His Leu Gly Lys Asn Phe Asp Phe Gln
                  85                  90                  95    
 Lys Ser Asp Arg Ile Asn Ser Glu Thr Asn Thr Lys Asn Leu Lys Ser
             100                 105                 110        
 Val Glu Ile Thr Met Lys Pro Ser Lys Ala Ser Glu Leu Asn Leu Asp
         115                 120                 125            
 Glu Leu Pro Pro Leu Asn Asn Tyr Leu His Val Phe Tyr Tyr Ser Trp
     130                 135                 140                
 Tyr Gly Asn Pro Gln Phe Asp Gly Lys Tyr Ile His Trp Asn His Pro
 145                 150                 155                 160
 Val Leu Glu His Trp Asp Pro Arg Ile Ala Lys Asn Tyr Pro Gln Gly
                 165                 170                 175    
 Arg His Asn Pro Pro Asp Asp Ile Gly Ser Ser Phe Tyr Pro Glu Leu
             180                 185                 190        
 Gly Ser Tyr Ser Ser Arg Asp Pro Ser Val Ile Glu Thr His Met Arg
         195                 200                 205            
 Gln Met Arg Ser Ala Ser Ile Gly Val Leu Ala Leu Ser Trp Tyr Pro
     210                 215                 220                
 Pro Asp Val Asn Asp Glu Asn Gly Glu Pro Thr Asp Asn Leu Val Pro
 225                 230                 235                 240
 Thr Ile Leu Asp Lys Ala His Lys Tyr Asn Leu Lys Val Thr Phe His
                 245                 250                 255    
 Ile Glu Pro Tyr Ser Asn Arg Asp Asp Gln Asn Met Tyr Lys Asn Val
             260                 265                 270        
 Lys Tyr Ile Ile Asp Lys Tyr Gly Asn His Pro Ala Phe Tyr Arg Tyr
         275                 280                 285            
 Lys Thr Lys Thr Gly Asn Ala Leu Pro Met Phe Tyr Val Tyr Asp Ser
     290                 295                 300                
 Tyr Ile Thr Lys Pro Glu Lys Trp Ala Asn Leu Leu Thr Thr Ser Gly
 305                 310                 315                 320
 Ser Arg Ser Ile Arg Asn Ser Pro Tyr Asp Gly Leu Phe Ile Ala Leu
                 325                 330                 335    
 Leu Val Glu Glu Lys His Lys Tyr Asp Ile Leu Gln Ser Gly Phe Asp
             340                 345                 350        
 Gly Ile Tyr Thr Tyr Phe Ala Thr Asn Gly Phe Thr Tyr Gly Ser Ser
         355                 360                 365            
 His Gln Asn Trp Ala Ser Leu Lys Leu Phe Cys Asp Lys Tyr Asn Leu
     370                 375                 380                
 Ile Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg
 385                 390                 395                 400
 Pro Trp Asn Thr Gln Asn Thr Arg Asn Arg Ile Asn Gly Lys Tyr Tyr
                 405                 410                 415    
 Glu Ile Gly Leu Ser Ala Ala Leu Gln Thr Arg Pro Ser Leu Ile Ser
             420                 425                 430        
 Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala
         435                 440                 445            
 Val Pro Lys Arg Thr Ser Asn Thr Val Tyr Leu Asp Tyr Arg Pro His
     450                 455                 460                
 Lys Pro Gly Leu Tyr Leu Glu Leu Thr Arg Lys Trp Ser Glu Lys Tyr
 465                 470                 475                 480
 Ser Lys Glu Arg Ala Thr Tyr Ala Leu Asp Arg Gln Leu Pro Val Ser
                 485                 490                 495    





      <210> 432
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 432
 Met Ala Glu Gln Gln Gly Arg Glu Leu Glu Ala Glu Cys Pro Val Cys
   1               5                  10                  15    
 Trp Asn Pro Phe Asn Asn Thr Phe His Thr Pro Lys Met Leu Asp Cys
              20                  25                  30        
 Cys His Ser Phe Cys Val Glu Cys Leu Ala His Leu Ser Leu Val Thr
          35                  40                  45            
 Pro Ala Arg Arg Arg Leu Leu Cys Pro Leu Cys Arg Gln Pro Thr Val
      50                  55                  60                
 Leu Ala Ser Gly Gln Pro Val Thr Asp Leu Pro Thr Asp Thr Ala Met
  65                  70                  75                  80
 Leu Thr Leu Leu Arg Leu Glu Pro His His Val Ile Leu Glu Gly His
                  85                  90                  95    
 Gln Leu Cys Leu Lys Asp Gln Pro Lys Ser Arg Tyr Phe Leu Arg Gln
             100                 105                 110        
 Pro Arg Val Tyr Thr Leu Asp Leu Gly Pro Gln Pro Trp Gly Pro Asp
         115                 120                 125            
 Trp Ala Ala Pro Arg His Gly Leu Cys His Arg Val Tyr Ala His Pro
     130                 135                 140                
 His Pro Gln Pro Pro Leu Phe Glu Gly Val Phe Pro Gln Pro Ser Val
 145                 150                 155                 160
 Pro His Leu Cys Leu Pro Asp Gly Arg His Pro Gln Cys His Ser Val
                 165                 170                 175    
 Ala His Ile Leu His Leu Leu Asp Gln Ala Val Pro Leu Gly Cys Gly
             180                 185                 190        
 Val Ser Ala Val Pro Arg Gln Glu Thr Lys Pro Phe Ser Val Ala Ala
         195                 200                 205            
 Gly Tyr Gly Asp Tyr Gly Ala Ser Phe Gly Ile Val Phe Leu Cys Ser
     210                 215                 220                
 Val Val Tyr Phe Thr Ile Gln Gly Leu Phe Arg Pro Cys Val Cys Phe
 225                 230                 235                 240
 Trp Glu Gln Phe Lys Lys Lys Thr Lys Lys Arg Lys Ala
                 245                 250            



      <210> 433
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 433
 Met Glu Asp Phe Ala Thr Arg Thr Tyr Gly Thr Ser Gly Leu Asp Asn
   1               5                  10                  15    
 Arg Pro Leu Phe Gly Glu Thr Ser Ala Lys Asp Arg Ile Ile Asn Leu
              20                  25                  30        
 Val Val Gly Ser Leu Thr Ser Leu Leu Ile Leu Val Thr Leu Ile Ser
          35                  40                  45            
 Ala Phe Val Phe Pro Gln Leu Pro Pro Lys Pro Leu Asn Ile Phe Phe
      50                  55                  60                
 Ala Val Cys Ile Ser Leu Ser Ser Ile Thr Ala Cys Ile Leu Ile Tyr
  65                  70                  75                  80
 Trp Tyr Arg Gln Gly Asp Leu Glu Pro Lys Phe Arg Lys Leu Ile Tyr
                  85                  90                  95    
 Tyr Ile Ile Phe Ser Ile Ile Met Leu Cys Ile Cys Ala Asn Leu Tyr
             100                 105                 110        
 Phe His Asp Val Gly Arg
         115            



      <210> 434
      <211> 303
      <212> PRT
      <213> Homo sapiens


      <400> 434
 Met Thr Arg Ala Arg Ile Gly Cys Phe Gly Pro Gly Gly Arg Ala Arg
   1               5                  10                  15    
 Gly Thr Glu Ser Ala Pro Glu Pro Ser Lys Arg Val Pro Pro Gly Arg
              20                  25                  30        
 Ser Trp Gln Thr Gln Glu Val Arg Gln Thr Arg Gly Ala Asn Gly Leu
          35                  40                  45            
 Gly Pro Arg Ala Gly Ser Ala Gly Ala Lys Ala Pro Gly Pro Ala Gln
      50                  55                  60                
 Gly Ala Ala Gln His Gly Leu Gly Gly Ser Ala Gly Leu Arg Val Arg
  65                  70                  75                  80
 Val Ser Pro Leu Ala Met Gly Ser Ala Ala Leu Glu Ile Leu Gly Leu
                  85                  90                  95    
 Val Leu Cys Leu Val Gly Trp Gly Gly Leu Ile Leu Ala Cys Gly Leu
             100                 105                 110        
 Pro Met Trp Gln Val Thr Ala Phe Leu Asp His Asn Ile Val Thr Ala
         115                 120                 125            
 Gln Thr Thr Trp Lys Gly Leu Trp Met Ser Cys Val Val Gln Ser Thr
     130                 135                 140                
 Gly His Met Gln Cys Lys Val Tyr Asp Ser Val Leu Ala Leu Ser Thr
 145                 150                 155                 160
 Glu Val Gln Ala Ala Arg Ala Leu Thr Val Ser Ala Val Leu Leu Ala
                 165                 170                 175    
 Phe Val Ala Leu Phe Val Thr Leu Ala Gly Ala Gln Cys Thr Thr Cys
             180                 185                 190        
 Val Ala Pro Gly Pro Ala Lys Ala Arg Val Ala Leu Thr Gly Gly Val
         195                 200                 205            
 Leu Tyr Leu Phe Cys Gly Leu Leu Ala Leu Val Pro Leu Cys Trp Phe
     210                 215                 220                
 Ala Asn Ile Val Val Arg Glu Phe Tyr Asp Pro Ser Val Pro Val Ser
 225                 230                 235                 240
 Gln Lys Tyr Glu Leu Gly Ala Ala Leu Tyr Ile Gly Trp Ala Ala Thr
                 245                 250                 255    
 Ala Leu Leu Met Val Gly Gly Cys Leu Leu Cys Cys Gly Ala Trp Val
             260                 265                 270        
 Cys Thr Gly Arg Pro Asp Leu Ser Phe Pro Val Lys Tyr Ser Ala Pro
         275                 280                 285            
 Arg Arg Pro Thr Ala Thr Gly Asp Tyr Asp Lys Lys Asn Tyr Val
     290                 295                 300            



      <210> 435
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 435
 Met Gly Lys Thr Phe Ser Gln Leu Gly Ser Trp Arg Glu Asp Glu Asn
   1               5                  10                  15    
 Lys Ser Ile Leu Ser Ser Lys Pro Ala Ile Gly Ser Lys Ala Val Asn
              20                  25                  30        
 Tyr Ser Ser Thr Gly Ser Ser Lys Ser Phe Cys Ser Cys Val Pro Cys
          35                  40                  45            
 Glu Gly Thr Ala Asp Ala Ser Phe Val Thr Cys Pro Thr Cys Gln Gly
      50                  55                  60                
 Ser Gly Lys Ile Pro Gln Glu Leu Glu Lys Gln Leu Val Ala Leu Ile
  65                  70                  75                  80
 Pro Tyr Gly Asp Gln Arg Leu Lys Pro Lys His Thr Lys Leu Phe Val
                  85                  90                  95    
 Phe Leu Ala Val Leu Ile Cys Leu Val Thr Ser Ser Phe Ile Val Phe
             100                 105                 110        
 Phe Leu Phe Pro Arg Ser Val Ile Val Gln Pro Ala Gly Leu Asn Ser
         115                 120                 125            
 Ser Thr Val Ala Phe Asp Glu Ala Asp Ile Tyr Leu Asn Ile Thr Asn
     130                 135                 140                
 Ile Leu Asn Ile Ser Asn Gly Asn Tyr Tyr Pro Ile Met Val Thr Gln
 145                 150                 155                 160
 Leu Thr Leu Glu Val Leu His Leu Ser Leu Val Val Gly Gln Val Ser
                 165                 170                 175    
 Asn Asn Leu Leu Leu His Ile Gly Pro Leu Ala Ser Glu Gln Met Phe
             180                 185                 190        
 Tyr Ala Val Ala Thr Lys Ile Arg Asp Glu Asn Thr Tyr Lys Ile Cys
         195                 200                 205            
 Thr Trp Leu Glu Ile Lys Val His His Val Leu Leu His Ile Gln Gly
     210                 215                 220                
 Thr Leu Thr Cys Ser Tyr Leu Ser His Ser Glu Gln Leu Val Phe Gln
 225                 230                 235                 240
 Ser Tyr Glu Tyr Val Asp Cys Arg Gly Asn Ala Ser Val Pro His Gln
                 245                 250                 255    
 Leu Thr Pro His Pro Pro
             260        



      <210> 436
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 436
 Met Gly Lys Glu Lys Arg Leu Ser Val His Leu Ile Leu Ala Thr Pro
   1               5                  10                  15    
 Pro Tyr Thr Ser Pro Ser Glu Asn Leu Pro Ser Pro Lys Tyr Ile Leu
              20                  25                  30        
 Leu Ala Leu His Leu Arg Asn Cys Cys Ser His Cys Pro His Asn Thr
          35                  40                  45            
 Pro Ile Ser Thr Phe Leu Pro Thr Leu Arg Tyr Cys Met His Ile Tyr
      50                  55                  60                
 Ile Phe Pro Leu Phe Lys Ile Gln Ile Ala Tyr Tyr Ala Cys Cys Ser
  65                  70                  75                  80
 Ala Leu Cys Phe Phe Phe Ile Leu Ala Ile Arg Ala Ala Ser Phe His
                  85                  90                  95    
 Phe Thr Ala Val Tyr Tyr Ser Ile Glu Trp Ile Asn His Asn Leu Phe
             100                 105                 110        
 Asn Gln Ser Leu Thr Asp Arg Arg Phe His Cys Phe Leu Ser Phe Ala
         115                 120                 125            
 Ile Asn Asn Ala Val Met Asn Ile Leu Val His Ile Ser His
     130                 135                 140        



      <210> 437
      <211> 743
      <212> PRT
      <213> Homo sapiens


      <400> 437
 Met Leu Lys Val Gln Val Asn Asp Ile Ile Ser Arg Gln Tyr Leu Ser
   1               5                  10                  15    
 Gln Ala Val Val Glu Val Phe Val Asn Tyr Thr Lys Thr Asn Ser Thr
              20                  25                  30        
 Val Thr Lys Ser Asn Gly Ala Val Leu Ile Lys Val Pro Tyr Lys Leu
          35                  40                  45            
 Gly Leu Ser Leu Thr Ile Ile Ala Tyr Lys Asp Gly Tyr Val Leu Thr
      50                  55                  60                
 Pro Leu Pro Trp Lys Thr Arg Arg Met Pro Ile Tyr Ser Ser Val Thr
  65                  70                  75                  80
 Leu Ser Leu Phe Pro Gln Ser Gln Ala Asn Ile Trp Leu Phe Glu Asp
                  85                  90                  95    
 Thr Val Leu Ile Thr Gly Lys Leu Ala Asp Ala Lys Ser Gln Pro Ser
             100                 105                 110        
 Val Gln Phe Ser Lys Ala Leu Ile Lys Leu Pro Asp Asn His His Ile
         115                 120                 125            
 Ser Asn Val Thr Gly Tyr Leu Thr Val Leu Gln Gln Phe Leu Lys Val
     130                 135                 140                
 Asp Asn Phe Leu His Thr Thr Gly Ile Thr Leu Asn Lys Pro Gly Phe
 145                 150                 155                 160
 Glu Asn Ile Glu Leu Thr Pro Leu Ala Ala Ile Cys Val Lys Ile Tyr
                 165                 170                 175    
 Ser Gly Gly Lys Glu Leu Lys Val Asn Gly Ser Ile Gln Val Ser Leu
             180                 185                 190        
 Pro Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly Asp Arg Ile Pro Ala
         195                 200                 205            
 Trp Thr Phe Asp Met Asn Thr Gly Ala Trp Val Asn His Gly Arg Gly
     210                 215                 220                
 Met Val Lys Glu His Asn Asn His Leu Ile Trp Thr Tyr Asp Ala Pro
 225                 230                 235                 240
 His Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro Gly Thr Arg Gly Ser
                 245                 250                 255    
 Gly Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala Tyr His Thr Val Phe
             260                 265                 270        
 Leu Thr Ala Ile Leu Gly Gly Thr Ile Val Ile Val Ile Gly Phe Phe
         275                 280                 285            
 Ala Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys Gly Thr Pro Gln Lys
     290                 295                 300                
 Arg Glu Arg Asn Ile Thr Lys Leu Glu Val Leu Lys Arg Asp Gln Thr
 305                 310                 315                 320
 Thr Ser Thr Thr His Ile Asn His Ile Ser Thr Val Lys Val Ala Leu
                 325                 330                 335    
 Lys Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala Lys Asn Ser Ser Tyr
             340                 345                 350        
 Ser Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu Thr Glu Glu Arg Val
         355                 360                 365            
 Ser Met Val Lys Thr Arg Asp Asp Phe Lys Ile Tyr Asn Glu Asp Val
     370                 375                 380                
 Ser Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser Arg Asn Pro Thr Gln
 385                 390                 395                 400
 Ser Leu Glu Pro Asn Val Gly Ser Lys Gln Pro Lys His Ile Asn Asn
                 405                 410                 415    
 Asn Leu Ser Ser Ser Leu Gly Asp Ala Gln Asp Glu Lys Arg Tyr Leu
             420                 425                 430        
 Thr Gly Asn Glu Glu Ala Tyr Gly Arg Ser His Ile Pro Glu Gln Leu
         435                 440                 445            
 Met His Ile Tyr Ser Gln Pro Ile Ala Ile Leu Gln Thr Ser Asp Leu
     450                 455                 460                
 Phe Ser Thr Pro Glu Gln Leu His Thr Ala Lys Ser Ala Thr Leu Pro
 465                 470                 475                 480
 Arg Lys Gly Gln Leu Val Tyr Gly Gln Leu Met Glu Pro Val Asn Arg
                 485                 490                 495    
 Glu Asn Phe Thr Gln Thr Leu Pro Lys Met Pro Ile His Ser His Ala
             500                 505                 510        
 Gln Pro Pro Asp Ala Arg Glu Glu Asp Ile Ile Leu Glu Gly Gln Gln
         515                 520                 525            
 Ser Leu Pro Ser Gln Ala Ser Asp Trp Ser Arg Tyr Ser Ser Ser Leu
     530                 535                 540                
 Leu Glu Ser Val Ser Val Pro Gly Thr Leu Asn Glu Ala Val Val Met
 545                 550                 555                 560
 Thr Pro Phe Ser Ser Glu Leu Gln Gly Ile Ser Glu Gln Thr Leu Leu
                 565                 570                 575    
 Glu Leu Ser Lys Gly Lys Pro Ser Pro His Pro Arg Ala Trp Phe Val
             580                 585                 590        
 Ser Leu Asp Gly Lys Pro Val Ala Gln Val Arg His Ser Phe Ile Asp
         595                 600                 605            
 Leu Lys Lys Gly Lys Arg Thr Gln Ser Asn Asp Thr Ser Leu Asp Ser
     610                 615                 620                
 Gly Val Asp Met Asn Glu Leu His Ser Ser Arg Lys Leu Glu Arg Glu
 625                 630                 635                 640
 Lys Thr Phe Ile Lys Ser Met His Gln Pro Lys Ile Leu Tyr Leu Glu
                 645                 650                 655    
 Asp Leu Asp Leu Ser Ser Ser Glu Ser Gly Thr Thr Val Cys Ser Pro
             660                 665                 670        
 Glu Asp Pro Ala Leu Arg His Ile Leu Asp Gly Gly Ser Gly Val Ile
         675                 680                 685            
 Met Glu His Pro Gly Glu Glu Ser Pro Gly Arg Lys Ser Thr Val Glu
     690                 695                 700                
 Asp Phe Glu Ala Asn Thr Ser Pro Thr Lys Arg Arg Gly Arg Pro Pro
 705                 710                 715                 720
 Leu Ala Lys Arg Asp Ser Lys Thr Asn Ile Trp Lys Lys Arg Glu Glu
                 725                 730                 735    
 Arg Pro Leu Ile Pro Ile Asn
             740            



      <210> 438
      <211> 748
      <212> PRT
      <213> Homo sapiens


      <400> 438
 Met Ser Ser Gly Gly Arg Phe Asn Phe Asp Asp Gly Gly Ser Tyr Cys
   1               5                  10                  15    
 Gly Gly Trp Glu Asp Gly Lys Ala His Gly His Gly Val Cys Thr Gly
              20                  25                  30        
 Pro Lys Gly Gln Gly Glu Tyr Thr Gly Ser Trp Ser His Gly Phe Glu
          35                  40                  45            
 Val Leu Gly Val Tyr Thr Trp Pro Ser Gly Asn Thr Tyr Gln Gly Thr
      50                  55                  60                
 Trp Ala Gln Gly Lys Arg His Gly Ile Gly Leu Glu Ser Lys Gly Lys
  65                  70                  75                  80
 Trp Val Tyr Lys Gly Glu Trp Thr His Gly Phe Lys Gly Arg Tyr Gly
                  85                  90                  95    
 Val Arg Glu Cys Ala Gly Asn Gly Ala Lys Tyr Glu Gly Thr Trp Ser
             100                 105                 110        
 Asn Gly Leu Gln Asp Gly Tyr Gly Thr Glu Thr Tyr Ser Asp Gly Gly
         115                 120                 125            
 Thr Tyr Gln Gly Gln Trp Val Gly Gly Met Arg Gln Gly Tyr Gly Val
     130                 135                 140                
 Arg Gln Ser Val Pro Tyr Gly Met Ala Ala Val Ile Arg Ser Pro Leu
 145                 150                 155                 160
 Arg Thr Ser Ile Asn Ser Leu Arg Ser Glu His Thr Asn Gly Thr Ala
                 165                 170                 175    
 Leu His Pro Asp Ala Ser Pro Ala Val Ala Gly Ser Pro Ala Val Ser
             180                 185                 190        
 Arg Gly Gly Phe Val Leu Val Ala His Ser Asp Ser Glu Ile Leu Lys
         195                 200                 205            
 Ser Lys Lys Lys Gly Leu Phe Arg Arg Ser Leu Leu Ser Gly Leu Lys
     210                 215                 220                
 Leu Arg Lys Ser Glu Ser Lys Ser Ser Leu Ala Ser Gln Arg Ser Lys
 225                 230                 235                 240
 Gln Ser Ser Phe Arg Ser Glu Ala Gly Met Ser Thr Val Ser Ser Thr
                 245                 250                 255    
 Ala Ser Asp Ile His Ser Thr Ile Ser Leu Gly Glu Ala Glu Ala Glu
             260                 265                 270        
 Leu Ala Val Ile Glu Asp Asp Ile Asp Ala Thr Thr Thr Glu Thr Tyr
         275                 280                 285            
 Val Gly Glu Trp Lys Asn Asp Lys Arg Ser Gly Phe Gly Val Ser Gln
     290                 295                 300                
 Arg Ser Asp Gly Leu Lys Tyr Glu Gly Glu Trp Ala Ser Asn Arg Arg
 305                 310                 315                 320
 His Gly Tyr Gly Cys Met Thr Phe Pro Asp Gly Thr Lys Glu Glu Gly
                 325                 330                 335    
 Lys Tyr Lys Gln Asn Ile Leu Val Gly Gly Lys Arg Lys Asn Leu Ile
             340                 345                 350        
 Pro Leu Arg Ala Ser Lys Ile Arg Glu Lys Val Asp Arg Ala Val Glu
         355                 360                 365            
 Ala Ala Glu Arg Ala Ala Thr Ile Ala Lys Gln Lys Ala Glu Ile Ala
     370                 375                 380                
 Ala Ser Arg Thr Ser His Ser Arg Ala Lys Ala Glu Ala Ala Leu Thr
 385                 390                 395                 400
 Ala Ala Gln Lys Ala Gln Glu Glu Ala Arg Ile Ala Arg Ile Thr Ala
                 405                 410                 415    
 Lys Glu Phe Ser Pro Ser Phe Gln His Arg Glu Asn Gly Leu Glu Tyr
             420                 425                 430        
 Gln Arg Pro Lys Arg Gln Thr Ser Cys Asp Asp Ile Glu Val Leu Ser
         435                 440                 445            
 Thr Gly Thr Pro Leu Gln Gln Glu Ser Pro Glu Leu Tyr Arg Lys Gly
     450                 455                 460                
 Thr Thr Pro Ser Asp Leu Thr Pro Asp Asp Ser Pro Leu Gln Ser Phe
 465                 470                 475                 480
 Pro Thr Ser Pro Ala Ala Thr Pro Pro Pro Ala Pro Ala Ala Arg Asn
                 485                 490                 495    
 Lys Val Ala His Phe Ser Arg Gln Val Ser Val Asp Glu Glu Arg Gly
             500                 505                 510        
 Gly Asp Ile Gln Met Leu Leu Glu Gly Arg Ala Gly Asp Cys Ala Arg
         515                 520                 525            
 Ser Ser Trp Gly Glu Glu Gln Ala Gly Gly Ser Arg Gly Val Arg Ser
     530                 535                 540                
 Gly Ala Leu Arg Gly Gly Leu Leu Val Asp Asp Phe Arg Thr Arg Gly
 545                 550                 555                 560
 Ser Gly Arg Lys Gln Pro Gly Asn Pro Lys Pro Arg Glu Arg Arg Thr
                 565                 570                 575    
 Glu Ser Pro Pro Val Phe Thr Trp Thr Ser His His Arg Ala Ser Asn
             580                 585                 590        
 His Ser Pro Gly Gly Ser Arg Leu Leu Glu Leu Gln Glu Glu Lys Leu
         595                 600                 605            
 Ser Asn Tyr Arg Met Glu Met Lys Pro Leu Leu Arg Met Glu Thr His
     610                 615                 620                
 Pro Gln Lys Arg Arg Tyr Ser Lys Gly Gly Ala Cys Arg Gly Leu Gly
 625                 630                 635                 640
 Asp Asp His Arg Pro Glu Asp Arg Gly Phe Gly Val Gln Arg Leu Arg
                 645                 650                 655    
 Ser Lys Ala Gln Asn Lys Glu Asn Phe Arg Pro Ala Ser Ser Ala Glu
             660                 665                 670        
 Pro Ala Val Gln Lys Leu Ala Ser Leu Arg Leu Gly Gly Ala Glu Pro
         675                 680                 685            
 Arg Leu Leu Arg Trp Asp Leu Thr Phe Ser Pro Pro Gln Lys Ser Leu
     690                 695                 700                
 Pro Val Ala Leu Glu Ser Asp Glu Glu Asn Gly Asp Glu Leu Lys Ser
 705                 710                 715                 720
 Ser Thr Gly Ser Ala Pro Ile Leu Val Val Met Val Ile Leu Leu Asn
                 725                 730                 735    
 Ile Gly Val Ala Ile Leu Phe Ile Asn Phe Phe Ile
             740                 745            



      <210> 439
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 439
 Met Ala Trp Glu Asn Arg Met Ala Leu Asp Met Ile Leu Ala Lys Lys
   1               5                  10                  15    
 Gly Gly Val Cys Val Met Ile Lys Thr Gln Cys Cys Thr Phe Ile Pro
              20                  25                  30        
 Asn Asn Thr Ala Pro Ser Gly Ser Ile Thr Arg Ala Leu Gln Gly Leu
          35                  40                  45            
 Thr Ala Leu Ser Asn Glu Leu Ala Lys Asn Ser Gly Val Asn Asp Pro
      50                  55                  60                
 Phe Ser Gly Trp Leu Glu Arg Trp Phe Gly Lys Trp Lys Gly Ile Ile
  65                  70                  75                  80
 Ala Ser Ile Leu Thr Ser Leu Ala Ala Val Ile Gly Val Val Ile Leu
                  85                  90                  95    
 Phe Gly Cys Cys Val Thr Pro Cys Ile Arg Gly Leu Val Gln Arg Leu
             100                 105                 110        
 Ile Glu Thr Val Leu Thr Lys Thr Ser Leu Ser Ser Pro Pro Pro Tyr
         115                 120                 125            
 Ser Asp Lys Leu Phe Leu Leu Lys Asp Gln Val Glu Gln Gln Ser Pro
     130                 135                 140                
 Asp Met Leu Lys Arg Phe Lys Glu Lys Arg Leu
 145                 150                 155



      <210> 440
      <211> 514
      <212> PRT
      <213> Homo sapiens


      <400> 440
 Met Ala Leu Gly Tyr Trp Arg Ala Gly Arg Ala Arg Asp Ala Ala Glu
   1               5                  10                  15    
 Phe Glu Leu Phe Phe Arg Arg Cys Pro Phe Gly Gly Ala Phe Ala Leu
              20                  25                  30        
 Ala Ala Gly Leu Arg Asp Cys Val Arg Phe Leu Arg Ala Phe Arg Leu
          35                  40                  45            
 Arg Asp Ala Asp Val Gln Phe Leu Ala Ser Val Leu Pro Pro Asp Thr
      50                  55                  60                
 Asp Pro Ala Phe Phe Glu His Leu Arg Ala Leu Asp Cys Ser Glu Val
  65                  70                  75                  80
 Thr Val Arg Ala Leu Pro Glu Gly Ser Leu Ala Phe Pro Gly Val Pro
                  85                  90                  95    
 Leu Leu Gln Val Ser Gly Pro Leu Leu Val Val Gln Leu Leu Glu Thr
             100                 105                 110        
 Pro Leu Leu Cys Leu Val Ser Tyr Ala Ser Leu Val Ala Thr Asn Ala
         115                 120                 125            
 Ala Arg Leu Arg Leu Ile Ala Gly Pro Glu Lys Arg Leu Leu Glu Met
     130                 135                 140                
 Gly Leu Arg Arg Ala Gln Gly Pro Asp Gly Gly Leu Thr Ala Ser Thr
 145                 150                 155                 160
 Tyr Ser Tyr Leu Gly Gly Phe Asp Ser Ser Ser Asn Val Leu Ala Gly
                 165                 170                 175    
 Gln Leu Arg Gly Val Pro Val Ala Gly Thr Leu Ala His Ser Phe Val
             180                 185                 190        
 Thr Ser Phe Ser Gly Ser Glu Val Pro Pro Asp Pro Met Leu Ala Pro
         195                 200                 205            
 Ala Ala Gly Glu Gly Pro Gly Val Asp Leu Ala Ala Lys Ala Gln Val
     210                 215                 220                
 Trp Leu Glu Gln Val Cys Ala His Leu Gly Leu Gly Val Gln Glu Pro
 225                 230                 235                 240
 His Pro Gly Glu Arg Ala Ala Phe Val Ala Tyr Ala Leu Ala Phe Pro
                 245                 250                 255    
 Arg Ala Phe Gln Gly Leu Leu Asp Thr Tyr Ser Val Trp Arg Ser Gly
             260                 265                 270        
 Leu Pro Asn Phe Leu Ala Val Ala Leu Ala Leu Gly Glu Leu Gly Tyr
         275                 280                 285            
 Arg Ala Val Gly Val Arg Leu Asp Ser Gly Asp Leu Leu Gln Gln Ala
     290                 295                 300                
 Gln Glu Ile Arg Lys Val Phe Arg Ala Ala Ala Ala Gln Phe Gln Val
 305                 310                 315                 320
 Pro Trp Leu Glu Ser Val Leu Ile Val Val Ser Asn Asn Ile Asp Glu
                 325                 330                 335    
 Glu Ala Leu Ala Arg Leu Ala Gln Glu Gly Ser Glu Val Asn Val Ile
             340                 345                 350        
 Gly Ile Gly Thr Ser Val Val Thr Cys Pro Gln Gln Pro Ser Leu Gly
         355                 360                 365            
 Gly Val Tyr Lys Leu Val Ala Val Gly Gly Gln Pro Arg Met Lys Leu
     370                 375                 380                
 Thr Glu Asp Pro Glu Lys Gln Thr Leu Pro Gly Ser Lys Ala Ala Phe
 385                 390                 395                 400
 Arg Leu Leu Gly Ser Asp Gly Ser Pro Leu Met Asp Met Leu Gln Leu
                 405                 410                 415    
 Ala Glu Glu Pro Val Pro Gln Ala Gly Gln Glu Leu Arg Val Trp Pro
             420                 425                 430        
 Pro Gly Ala Gln Glu Pro Cys Thr Val Arg Pro Ala Gln Val Glu Pro
         435                 440                 445            
 Leu Leu Arg Leu Cys Leu Gln Gln Gly Gln Leu Cys Glu Pro Leu Pro
     450                 455                 460                
 Ser Leu Ala Glu Ser Arg Ala Leu Ala Gln Leu Ser Leu Ser Arg Leu
 465                 470                 475                 480
 Ser Pro Glu His Arg Arg Leu Arg Ser Pro Ala Gln Tyr Gln Val Val
                 485                 490                 495    
 Leu Ser Glu Arg Leu Gln Ala Leu Val Asn Ser Leu Cys Ala Gly Gln
             500                 505                 510        
 Ser Pro
        



      <210> 441
      <211> 441
      <212> PRT
      <213> Homo sapiens


      <400> 441
 Met Ala Leu Gly Tyr Trp Arg Ala Gly Arg Ala Arg Asp Ala Ala Glu
   1               5                  10                  15    
 Phe Glu Leu Phe Phe Arg Arg Cys Pro Phe Gly Gly Ala Phe Ala Leu
              20                  25                  30        
 Ala Ala Gly Leu Arg Asp Cys Val Arg Phe Leu Arg Ala Phe Arg Leu
          35                  40                  45            
 Arg Asp Ala Asp Val Gln Phe Leu Ala Ser Val Leu Pro Pro Asp Thr
      50                  55                  60                
 Asp Pro Ala Phe Phe Glu His Leu Arg Ala Leu Asp Cys Ser Glu Val
  65                  70                  75                  80
 Thr Val Arg Ala Leu Pro Glu Gly Ser Leu Ala Phe Pro Gly Val Pro
                  85                  90                  95    
 Leu Leu Gln Val Ser Gly Pro Leu Leu Val Val Gln Leu Leu Glu Thr
             100                 105                 110        
 Pro Leu Leu Cys Leu Val Ser Tyr Ala Ser Leu Val Ala Thr Asn Ala
         115                 120                 125            
 Ala Arg Leu Arg Leu Ile Ala Gly Pro Glu Lys Arg Leu Leu Glu Met
     130                 135                 140                
 Gly Leu Arg Arg Ala Gln Gly Pro Asp Gly Gly Leu Thr Ala Ser Thr
 145                 150                 155                 160
 Tyr Ser Tyr Leu Gly Gly Phe Asp Ser Ser Ser Asn Val Leu Ala Gly
                 165                 170                 175    
 Gln Leu Arg Gly Val Pro Val Ala Gly Thr Leu Ala His Ser Phe Val
             180                 185                 190        
 Thr Ser Phe Ser Gly Ser Glu Val Pro Pro Asp Pro Met Leu Ala Pro
         195                 200                 205            
 Ala Ala Gly Glu Gly Pro Gly Val Asp Leu Ala Ala Lys Ala Gln Val
     210                 215                 220                
 Trp Leu Glu Gln Val Cys Ala His Leu Gly Leu Gly Val Gln Glu Pro
 225                 230                 235                 240
 His Pro Gly Glu Arg Ala Ala Phe Val Ala Tyr Ala Leu Ala Phe Pro
                 245                 250                 255    
 Arg Ala Phe Gln Gly Leu Leu Asp Thr Tyr Ser Val Trp Arg Ser Gly
             260                 265                 270        
 Leu Pro Asn Phe Leu Ala Val Ala Leu Ala Leu Gly Glu Leu Gly Tyr
         275                 280                 285            
 Arg Ala Val Gly Val Arg Leu Asp Ser Gly Asp Leu Leu Gln Gln Ala
     290                 295                 300                
 Gln Glu Ile Arg Lys Val Phe Arg Ala Ala Ala Ala Gln Phe Gln Val
 305                 310                 315                 320
 Pro Trp Leu Glu Ser Val Leu Ile Val Val Ser Asn Asn Ile Asp Glu
                 325                 330                 335    
 Glu Ala Leu Ala Arg Leu Ala Gln Glu Gly Ser Glu Val Asn Val Ile
             340                 345                 350        
 Gly Ile Gly Thr Ser Val Val Thr Cys Pro Gln Gln Pro Ser Leu Gly
         355                 360                 365            
 Gly Val Tyr Lys Leu Val Ala Val Gly Gly Gln Pro Arg Met Lys Leu
     370                 375                 380                
 Thr Glu Asp Pro Glu Lys Gln Thr Leu Pro Gly Ser Lys Ala Ala Phe
 385                 390                 395                 400
 Arg Leu Leu Gly Ser Asp Gly Glu Ala Leu Pro Ser Pro Leu Leu Ser
                 405                 410                 415    
 Thr Phe Lys Ala Pro Gly Pro Pro Leu Ile Leu Ala Pro Ser Thr Gln
             420                 425                 430        
 Gly Leu His Ser Trp Thr Cys Cys Ser
         435                 440    



      <210> 442
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 442
 Met Ala Leu Gly Tyr Trp Arg Ala Gly Arg Ala Arg Asp Ala Ala Glu
   1               5                  10                  15    
 Phe Glu Leu Phe Phe Arg Arg Cys Pro Phe Gly Gly Ala Phe Ala Leu
              20                  25                  30        
 Ala Ala Gly Leu Arg Asp Cys Val Arg Phe Leu Arg Ala Phe Arg Leu
          35                  40                  45            
 Arg Asp Ala Asp Val Gln Phe Leu Ala Ser Val Leu Pro Pro Asp Thr
      50                  55                  60                
 Asp Pro Ala Phe Phe Glu His Leu Arg Ala Leu Asp Cys Ser Glu Val
  65                  70                  75                  80
 Thr Val Arg Ala Leu Pro Glu Gly Ser Leu Ala Phe Pro Gly Val Pro
                  85                  90                  95    
 Leu Leu Gln Val Ser Gly Pro Leu Leu Val Val Gln Leu Leu Glu Thr
             100                 105                 110        
 Pro Leu Leu Cys Leu Val Ser Tyr Ala Ser Leu Val Ala Thr Asn Ala
         115                 120                 125            
 Ala Arg Leu Arg Leu Ile Ala Gly Pro Glu Lys Arg Leu Leu Glu Met
     130                 135                 140                
 Gly Leu Arg Arg Ala Gln Gly Pro Asp Gly Gly Leu Thr Ala Ser Thr
 145                 150                 155                 160
 Tyr Ser Tyr Leu Gly Gly Phe Asp Ser Ser Ser Asn Val Leu Ala Gly
                 165                 170                 175    
 Gln Leu Arg Gly Val Pro Val Ala Gly Thr Leu Ala His Ser Phe Val
             180                 185                 190        
 Thr Ser Phe Ser Gly Ser Glu Val Pro Pro Asp Pro Met Leu Ala Pro
         195                 200                 205            
 Ala Ala Gly Glu Gly Pro Gly Val Asp Leu Ala Ala Lys Ala Gln Val
     210                 215                 220                
 Trp Leu Glu Gln Val Cys Ala His Leu Gly Leu Gly Val Gln Glu Pro
 225                 230                 235                 240
 His Pro Gly Glu Arg Ala Ala Phe Val Ala Tyr Ala Leu Ala Phe Pro
                 245                 250                 255    
 Arg Ala Phe Gln Gly Leu Leu Asp Thr Tyr Ser Val Trp Arg Ser Gly
             260                 265                 270        
 Leu Pro Asn Phe Leu Ala Val Ala Leu Ala Leu Gly Glu Leu Gly Tyr
         275                 280                 285            
 Arg Ala Val Gly Val Arg Leu Asp Ser Gly Asp Leu Leu Gln Gln Ala
     290                 295                 300                
 Gln Glu Ile Arg Lys Val Phe Arg Ala Ala Ala Ala Gln Phe Gln Val
 305                 310                 315                 320
 Pro Trp Leu Glu Ser Val Leu Ile Val Val Ser Asn Asn Ile Asp Glu
                 325                 330                 335    
 Glu Ala Leu Ala Arg Leu Ala Gln Glu Gly Ser Glu Val Asn Val Ile
             340                 345                 350        
 Gly Ile Gly Thr Ser Val Val Thr Cys Pro Gln Gln Pro Ser Leu Gly
         355                 360                 365            
 Gly Val Tyr Lys Leu Val Ala Val Gly Gly Gln Pro Arg Met Lys Leu
     370                 375                 380                
 Thr Glu Asp Pro Glu Lys Gln Thr Leu Pro Gly Ser Lys Ala Ala Phe
 385                 390                 395                 400
 Arg Leu Leu Gly Ser Asp Gly Ser Pro Leu Met Asp Met Leu Gln Leu
                 405                 410                 415    
 Ala Glu Glu Pro Val Pro Gln Ala Gly Gln Glu Leu Arg Val Trp Pro
             420                 425                 430        
 Pro Gly Ala Gln Glu Pro Cys Thr Val Arg Pro Ala Gln Leu Cys Glu
         435                 440                 445            
 Pro Leu Pro Ser Leu Ala Glu Ser Arg Ala Leu Ala Gln Leu Ser Leu
     450                 455                 460                
 Ser Arg Leu Ser Pro Glu His Arg Arg Leu Arg Ser Pro Ala Gln Tyr
 465                 470                 475                 480
 Gln Val Val Leu Ser Glu Arg Leu Gln Ala Leu Val Asn Ser Leu Cys
                 485                 490                 495    
 Ala Gly Gln Ser Pro
             500    



      <210> 443
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 443
 Met Arg Glu Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly
   1               5                  10                  15    
 Val Phe Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln
              20                  25                  30        
 Pro Glu Glu Ile Trp Leu Tyr Lys Asn Pro Leu Val Gln Ser Asp Asn
          35                  40                  45            
 Ile Pro Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala
      50                  55                  60                
 Val Ile Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile
  65                  70                  75                  80
 Lys Glu Ala Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val
                  85                  90                  95    
 Cys Thr Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe
             100                 105                 110        
 Phe Tyr Arg Cys Phe Pro Asp Gly Val Met Asn Ser Glu Met His Cys
         115                 120                 125            
 Thr Gly Asp Pro Asp Leu Val Ser Glu Gly Arg Lys Ser Phe Pro Ser
     130                 135                 140                
 Ile His Ser Ser Phe Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe Tyr
 145                 150                 155                 160
 Leu Ala Gly Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys Ser
                 165                 170                 175    
 Trp Arg Leu Cys Ala Ala Ile Leu Pro Leu Tyr Cys Ala Met Met Ile
             180                 185                 190        
 Ala Leu Ser Arg Met Cys Asp Tyr Lys His His Trp Gln Asp Ser Phe
         195                 200                 205            
 Val Gly Gly Val Ile Gly Leu Ile Phe Ala Tyr Ile Cys Tyr Arg Gln
     210                 215                 220                
 His Tyr Pro Pro Leu Ala Asn Thr Ala Cys His Lys Pro Tyr Val Ser
 225                 230                 235                 240
 Leu Arg Val Pro Ala Ser Leu Lys Lys Glu Glu Arg Pro Thr Ala Asp
                 245                 250                 255    
 Ser Ala Pro Ser Leu Ala Leu Glu Gly Ile Thr Ala Gly Pro Val
             260                 265                 270    



      <210> 444
      <211> 312
      <212> PRT
      <213> Homo sapiens


      <400> 444
 Met Met Asp Leu Phe Val Gln Met Ala Ile Ile Met Gly Leu Lys Gln
   1               5                  10                  15    
 Thr Leu Ser Asn Cys Val Glu Tyr Leu Val Pro Trp Val Thr His Lys
              20                  25                  30        
 Cys Arg Ser Leu Arg Ala Ser Glu Ser Gly His Leu Pro Arg Asp Pro
          35                  40                  45            
 Glu Leu Arg Asp Trp Arg Arg Asn Tyr Leu Leu Asn Pro Val Asn Thr
      50                  55                  60                
 Phe Ser Leu Phe Asp Glu Phe Met Glu Met Met Ile Gln Tyr Gly Phe
  65                  70                  75                  80
 Thr Thr Ile Phe Val Ala Ala Phe Pro Leu Ala Pro Leu Leu Ala Leu
                  85                  90                  95    
 Phe Ser Asn Leu Val Glu Ile Arg Leu Asp Ala Ile Lys Met Val Trp
             100                 105                 110        
 Leu Gln Arg Arg Leu Val Pro Arg Lys Ala Lys Asp Ile Gly Thr Trp
         115                 120                 125            
 Leu Gln Val Leu Glu Thr Ile Gly Val Leu Ala Val Ile Ala Asn Gly
     130                 135                 140                
 Met Val Ile Ala Phe Thr Ser Glu Phe Ile Pro Arg Val Val Tyr Lys
 145                 150                 155                 160
 Tyr Arg Tyr Ser Pro Cys Leu Lys Glu Gly Asn Ser Thr Val Asp Cys
                 165                 170                 175    
 Leu Lys Gly Tyr Val Asn His Ser Leu Ser Val Phe His Thr Lys Asp
             180                 185                 190        
 Phe Gln Asp Pro Asp Gly Ile Glu Gly Ser Glu Asn Val Thr Leu Cys
         195                 200                 205            
 Arg Tyr Arg Asp Tyr Arg Asn Pro Pro Asp Tyr Asn Phe Ser Glu Gln
     210                 215                 220                
 Phe Trp Phe Leu Leu Ala Ile Arg Leu Ala Phe Val Ile Leu Phe Glu
 225                 230                 235                 240
 His Val Ala Leu Cys Ile Lys Leu Ile Ala Ala Trp Phe Val Pro Asp
                 245                 250                 255    
 Ile Pro Gln Ser Val Lys Asn Lys Val Leu Glu Val Lys Tyr Gln Arg
             260                 265                 270        
 Leu Arg Glu Lys Met Trp His Gly Arg Gln Arg Leu Gly Gly Val Gly
         275                 280                 285            
 Ala Gly Ser Arg Pro Pro Met Pro Ala His Pro Thr Pro Ala Ser Ile
     290                 295                 300                
 Phe Ser Ala Arg Ser Thr Asp Val
 305                 310        



      <210> 445
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 445
 Met Leu Lys Arg Phe Arg Glu Pro Lys His Glu Arg Arg Pro Trp Arg
   1               5                  10                  15    
 Ile Trp Phe Leu Asp Thr Ser Lys Gln Ala Ile Gly Met Leu Phe Ile
              20                  25                  30        
 His Phe Ala Asn Val Tyr Leu Ala Asp Leu Thr Glu Glu Asp Pro Cys
          35                  40                  45            
 Ser Leu Tyr Leu Ile Asn Phe Leu Leu Asp Ala Thr Val Gly Met Leu
      50                  55                  60                
 Leu Ile Tyr Val Gly Val Arg Ala Val Ser Val Leu Val Glu Trp Gln
  65                  70                  75                  80
 Gln Trp Glu Ser Leu Arg Phe Gly Glu Tyr Gly Asp Pro Leu Gln Cys
                  85                  90                  95    
 Gly Ala Trp Val Gly Gln Cys Ala Leu Tyr Ile Val Ile Met Ile Phe
             100                 105                 110        
 Glu Lys Ser Val Val Phe Ile Val Leu Leu Ile Leu Gln Trp Lys Lys
         115                 120                 125            
 Val Ala Leu Leu Asn Pro Ile Glu Asn Pro Asp Leu Lys Leu Ala Ile
     130                 135                 140                
 Val Met Leu Ile Val Pro Phe Phe Val Asn Ala Leu Met Phe Trp Val
 145                 150                 155                 160
 Val Asp Asn Phe Leu Met Arg Lys Gly Lys Thr Lys Ala Lys Leu Glu
                 165                 170                 175    
 Glu Arg Gly Ala Asn Gln Asp Ser Arg Asn Gly Ser Lys Val Arg Tyr
             180                 185                 190        
 Arg Arg Ala Ala Ser His Glu Glu Ser Glu Ser Glu Ile Leu Ile Ser
         195                 200                 205            
 Ala Asp Asp Glu Met Glu Glu Ser Asp Val Glu Glu Asp Leu Arg Arg
     210                 215                 220                
 Leu Thr Pro Leu Lys Pro Val Lys Lys Lys Lys His Arg Phe Gly Leu
 225                 230                 235                 240
 Pro Val
        



      <210> 446
      <211> 430
      <212> PRT
      <213> Homo sapiens


      <400> 446
 Met Ala Glu Ala Val Leu Ile Asp Leu Phe Gly Leu Lys Leu Asn Ser
   1               5                  10                  15    
 Gln Lys Asn Cys His Gln Thr Leu Leu Lys Thr Leu Asn Ala Val Gln
              20                  25                  30        
 Tyr His His Ala Ala Lys Ala Lys Phe Leu Cys Ile Met Cys Cys Ser
          35                  40                  45            
 Asn Ile Ser Tyr Glu Arg Asp Gly Glu Gln Asp Asn Cys Glu Ile Glu
      50                  55                  60                
 Thr Ser Asn Gly Leu Ser Ala Leu Leu Glu Glu Phe Glu Ile Val Ser
  65                  70                  75                  80
 Cys Pro Ser Met Ala Ala Thr Leu Tyr Thr Ile Lys Gln Lys Ile Asp
                  85                  90                  95    
 Glu Lys Asn Leu Ser Ser Ile Lys Val Ile Val Pro Arg His Arg Lys
             100                 105                 110        
 Thr Leu Met Lys Ala Phe Ile Asp Gln Leu Phe Thr Asp Val Tyr Asn
         115                 120                 125            
 Phe Glu Phe Glu Asp Leu Gln Val Thr Phe Arg Gly Gly Leu Phe Lys
     130                 135                 140                
 Gln Ser Ile Glu Ile Asn Val Ile Thr Ala Gln Glu Leu Arg Gly Ile
 145                 150                 155                 160
 Gln Asn Glu Ile Glu Thr Phe Leu Arg Ser Leu Pro Ala Leu Arg Gly
                 165                 170                 175    
 Lys Leu Thr Ile Ile Thr Ser Ser Leu Ile Pro Asp Ile Phe Ile His
             180                 185                 190        
 Gly Phe Thr Thr Arg Thr Gly Gly Ile Ser Tyr Ile Pro Thr Leu Ser
         195                 200                 205            
 Ser Phe Asn Leu Phe Ser Ser Ser Lys Arg Arg Asp Pro Lys Val Val
     210                 215                 220                
 Val Gln Glu Asn Leu Arg Arg Leu Ala Asn Ala Ala Gly Phe Asn Val
 225                 230                 235                 240
 Glu Lys Phe Tyr Arg Ile Lys Thr His His Ser Asn Asp Ile Trp Ile
                 245                 250                 255    
 Met Gly Arg Lys Glu Pro Asp Ser Tyr Asp Gly Ile Thr Thr Asn Gln
             260                 265                 270        
 Arg Gly Val Thr Ile Ala Ala Leu Gly Ala Asp Cys Ile Pro Ile Val
         275                 280                 285            
 Phe Ala Asp Pro Val Lys Lys Ala Cys Gly Val Ala His Ala Gly Trp
     290                 295                 300                
 Lys Gly Thr Leu Leu Gly Val Ala Met Ala Thr Val Asn Ala Met Ile
 305                 310                 315                 320
 Ala Glu Tyr Gly Cys Ser Leu Glu Asp Ile Val Val Val Leu Gly Pro
                 325                 330                 335    
 Ser Val Gly Pro Cys Cys Phe Thr Leu Pro Arg Glu Ser Ala Glu Ala
             340                 345                 350        
 Phe His Asn Leu His Pro Ala Cys Val Gln Leu Phe Asp Ser Pro Asn
         355                 360                 365            
 Pro Cys Ile Asp Ile Arg Lys Ala Thr Arg Ile Leu Leu Glu Gln Gly
     370                 375                 380                
 Gly Ile Leu Pro Gln Asn Ile Gln Asp Gln Asn Gln Asp Leu Asn Leu
 385                 390                 395                 400
 Cys Thr Ser Cys His Pro Asp Lys Phe Phe Ser His Val Arg Asp Gly
                 405                 410                 415    
 Leu Asn Phe Gly Thr Gln Ile Gly Phe Ile Ser Ile Lys Glu
             420                 425                 430



      <210> 447
      <211> 240
      <212> PRT
      <213> Homo sapiens


      <400> 447
 Met Tyr Leu Arg Arg Ala Val Ser Lys Thr Leu Ala Leu Pro Leu Arg
   1               5                  10                  15    
 Ala Pro Pro Asn Pro Ala Pro Leu Gly Lys Asp Ala Ser Leu Arg Arg
              20                  25                  30        
 Met Ser Ser Asn Arg Phe Pro Gly Ser Ser Gly Ser Asn Met Ile Tyr
          35                  40                  45            
 Tyr Leu Val Val Gly Val Thr Val Ser Ala Gly Gly Tyr Tyr Ala Tyr
      50                  55                  60                
 Lys Thr Val Thr Ser Asp Gln Ala Lys His Thr Glu His Lys Thr Asn
  65                  70                  75                  80
 Leu Lys Glu Lys Thr Lys Ala Glu Ile His Pro Phe Gln Gly Glu Lys
                  85                  90                  95    
 Glu Asn Val Ala Glu Thr Glu Lys Ala Ser Ser Glu Ala Pro Glu Glu
             100                 105                 110        
 Leu Ile Val Glu Ala Glu Val Val Asp Ala Glu Glu Ser Pro Ser Ala
         115                 120                 125            
 Thr Val Val Val Ile Lys Glu Ala Ser Ala Cys Pro Gly His Val Glu
     130                 135                 140                
 Ala Ala Pro Glu Thr Thr Ala Val Ser Ala Glu Thr Gly Pro Glu Val
 145                 150                 155                 160
 Thr Asp Ala Ala Ala Arg Glu Thr Thr Glu Val Asn Pro Glu Thr Thr
                 165                 170                 175    
 Pro Glu Val Thr Asn Ala Ala Leu Asp Glu Ala Val Thr Ile Asp Asn
             180                 185                 190        
 Asp Lys Asp Thr Thr Lys Asn Glu Thr Ser Asp Glu Tyr Ala Glu Leu
         195                 200                 205            
 Glu Glu Glu Asn Ser Pro Ala Glu Ser Glu Ser Ser Ala Gly Asp Asp
     210                 215                 220                
 Leu Gln Glu Glu Ala Ser Val Gly Ser Glu Ala Ala Ser Ala Gln Gly
 225                 230                 235                 240





      <210> 448
      <211> 330
      <212> PRT
      <213> Homo sapiens


      <400> 448
 Met Ala Ser Arg Glu Asp Glu Leu Arg Asn Cys Val Val Cys Gly Asp
   1               5                  10                  15    
 Gln Ala Thr Gly Tyr His Phe Asn Ala Leu Thr Cys Glu Gly Cys Lys
              20                  25                  30        
 Gly Phe Phe Arg Arg Thr Val Ser Gln Arg Arg His Cys Pro Ala Cys
          35                  40                  45            
 Arg Leu Gln Lys Cys Leu Asp Ala Gly Met Arg Lys Asp Met Ile Leu
      50                  55                  60                
 Ser Ala Glu Ala Leu Ala Leu Arg Arg Ala Lys Gln Ala Gln Arg Arg
  65                  70                  75                  80
 Ala Gln Gln Thr Pro Val Gln Leu Ser Lys Glu Gln Glu Glu Leu Ile
                  85                  90                  95    
 Arg Thr Leu Leu Gly Ala His Thr Arg His Met Gly Thr Met Phe Glu
             100                 105                 110        
 Gln Phe Val Gln Phe Arg Pro Pro Ala His Leu Phe Ile His His Gln
         115                 120                 125            
 Pro Leu Pro Thr Leu Ala Pro Val Leu Pro Leu Val Thr His Phe Ala
     130                 135                 140                
 Asp Ile Asn Thr Phe Met Val Leu Gln Val Ile Lys Phe Thr Lys Asp
 145                 150                 155                 160
 Leu Pro Val Phe Arg Ser Leu Pro Ile Glu Asp Gln Ile Ser Leu Leu
                 165                 170                 175    
 Lys Gly Ala Ala Val Glu Ile Cys His Ile Val Leu Asn Thr Thr Phe
             180                 185                 190        
 Cys Leu Gln Thr Gln Asn Phe Leu Cys Gly Pro Leu Arg Tyr Thr Ile
         195                 200                 205            
 Glu Asp Gly Ala Arg Val Gly Phe Gln Val Glu Phe Leu Glu Leu Leu
     210                 215                 220                
 Phe His Phe His Gly Thr Leu Arg Lys Leu Gln Leu Gln Glu Pro Glu
 225                 230                 235                 240
 Tyr Val Leu Leu Ala Ala Met Ala Leu Phe Ser Pro Asp Arg Pro Gly
                 245                 250                 255    
 Val Thr Gln Arg Asp Glu Ile Asp Gln Leu Gln Glu Glu Met Ala Leu
             260                 265                 270        
 Thr Leu Gln Ser Tyr Ile Lys Gly Gln Gln Arg Arg Pro Arg Asp Arg
         275                 280                 285            
 Phe Leu Tyr Ala Lys Leu Leu Gly Leu Leu Ala Glu Leu Arg Ser Ile
     290                 295                 300                
 Asn Glu Ala Tyr Gly Tyr Gln Ile Gln His Ile Gln Gly Leu Ser Ala
 305                 310                 315                 320
 Met Met Pro Leu Leu Gln Glu Ile Cys Ser
                 325                 330



      <210> 449
      <211> 623
      <212> PRT
      <213> Homo sapiens


      <400> 449
 Met Asp Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val
   1               5                  10                  15    
 Asn Asp Phe Pro Ser Ala Met Gln Glu Gly Ser Glu Val Leu Lys Val
              20                  25                  30        
 Val Ala Met Asp Gly Asp Arg Gly Lys Pro Asn Arg Ile Leu Tyr Ser
          35                  40                  45            
 Leu Val Asn Gly Asn Asp Gly Ala Phe Glu Ile Asn Glu Thr Ser Gly
      50                  55                  60                
 Ala Ile Ser Ile Thr Gln Ser Pro Ala Gln Leu Gln Arg Glu Val Tyr
  65                  70                  75                  80
 Glu Leu His Val Gln Val Thr Glu Met Ser Pro Ala Gly Ser Pro Ala
                  85                  90                  95    
 Ala Gln Ala Thr Val Pro Val Thr Ile Arg Ile Val Asp Leu Asn Asn
             100                 105                 110        
 His Pro Pro Thr Phe Tyr Gly Glu Ser Gly Pro Gln Asn Arg Phe Glu
         115                 120                 125            
 Leu Ser Met Asn Glu His Pro Pro Gln Gly Glu Ile Leu Arg Gly Leu
     130                 135                 140                
 Lys Ile Thr Val Asn Asp Ser Asp Gln Gly Ala Asn Ala Lys Phe Asn
 145                 150                 155                 160
 Leu Gln Leu Val Gly Pro Arg Gly Ile Phe Arg Val Val Pro Gln Thr
                 165                 170                 175    
 Val Leu Asn Glu Ala Gln Val Thr Ile Ile Val Glu Asn Ser Ala Ala
             180                 185                 190        
 Ile Asp Phe Glu Lys Ser Lys Val Leu Thr Phe Lys Leu Leu Ala Val
         195                 200                 205            
 Glu Val Asn Thr Pro Glu Lys Phe Ser Ser Thr Ala Asp Val Val Ile
     210                 215                 220                
 Gln Leu Leu Asp Thr Asn Asp Asn Val Pro Lys Phe Asp Ser Leu Tyr
 225                 230                 235                 240
 Tyr Val Ala Arg Ile Pro Glu Asn Ala Pro Gly Gly Ser Ser Val Val
                 245                 250                 255    
 Ala Val Thr Ala Val Asp Pro Asp Thr Gly Pro Trp Gly Glu Val Lys
             260                 265                 270        
 Tyr Ser Thr Tyr Gly Thr Gly Ala Asp Leu Phe Leu Ile His Pro Ser
         275                 280                 285            
 Thr Gly Leu Ile Tyr Thr Gln Pro Trp Ala Ser Leu Asp Ala Glu Ala
     290                 295                 300                
 Thr Ala Arg Tyr Asn Phe Tyr Val Lys Ala Glu Asp Met Glu Gly Lys
 305                 310                 315                 320
 Tyr Ser Val Ala Glu Val Phe Ile Thr Leu Leu Asp Val Asn Asp His
                 325                 330                 335    
 Pro Pro Gln Phe Gly Lys Ser Val Gln Lys Lys Thr Met Val Leu Gly
             340                 345                 350        
 Thr Pro Val Lys Ile Glu Ala Ile Asp Glu Asp Ala Glu Glu Pro Asn
         355                 360                 365            
 Asn Leu Val Asp Tyr Ser Ile Thr His Ala Glu Pro Ala Asn Val Phe
     370                 375                 380                
 Asp Ile Asn Ser His Thr Gly Glu Ile Trp Leu Lys Asn Ser Ile Arg
 385                 390                 395                 400
 Ser Leu Asp Ala Leu His Asn Ile Thr Pro Gly Arg Asp Cys Leu Trp
                 405                 410                 415    
 Ser Leu Glu Val Gln Ala Lys Asp Arg Gly Ser Pro Ser Phe Ser Thr
             420                 425                 430        
 Thr Ala Leu Leu Lys Ile Asp Ile Thr Asp Ala Glu Thr Leu Ser Arg
         435                 440                 445            
 Ser Pro Met Ala Ala Phe Leu Ile Gln Thr Lys Asp Asn Pro Met Lys
     450                 455                 460                
 Ala Val Gly Val Leu Ala Gly Thr Met Ala Thr Val Val Ala Ile Thr
 465                 470                 475                 480
 Val Leu Ile Ser Thr Ala Thr Phe Trp Arg Asn Lys Lys Ser Asn Lys
                 485                 490                 495    
 Val Leu Pro Met Arg Arg Val Leu Arg Lys Arg Pro Ser Pro Ala Pro
             500                 505                 510        
 Arg Thr Ile Arg Ile Glu Trp Leu Lys Ser Lys Ser Thr Lys Ala Ala
         515                 520                 525            
 Thr Lys Phe Met Leu Lys Glu Lys Pro Pro Asn Glu Asn Cys Asn Asn
     530                 535                 540                
 Asn Ser Pro Glu Ser Ser Leu Leu Pro Arg Ala Pro Ala Leu Pro Pro
 545                 550                 555                 560
 Pro Pro Ser Val Ala Pro Ser Thr Gly Ala Ala Gln Trp Thr Val Pro
                 565                 570                 575    
 Thr Val Ser Gly Ser Leu Thr Pro Gln Pro Thr Gln Pro Pro Pro Lys
             580                 585                 590        
 Pro Lys Thr Met Gly Ser Pro Val Gln Ser Thr Leu Ile Ser Glu Leu
         595                 600                 605            
 Lys Gln Lys Phe Glu Lys Lys Ser Val His Asn Lys Ala Tyr Phe
     610                 615                 620            



      <210> 450
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 450
 Met Ala Leu Ser Leu Pro Leu Gly Pro Arg Leu Gly Ser Glu Pro Leu
   1               5                  10                  15    
 Asn His Pro Pro Gly Ala Pro Arg Glu Ala Asp Ile Val Gly Cys Thr
              20                  25                  30        
 Val Cys Pro Ala Ser Gly Glu Glu Ser Thr Ser Pro Glu Gln Ala Gln
          35                  40                  45            
 Thr Leu Gly Gln Asp Ser Leu Gly Pro Pro Glu His Phe Gln Gly Gly
      50                  55                  60                
 Pro Arg Gly Asn Glu Pro Ala Ala His Pro Pro Arg Trp Ser Thr Pro
  65                  70                  75                  80
 Ser Ser Tyr Glu Asp Pro Ala Gly Gly Lys His Cys Glu His Pro Ile
                  85                  90                  95    
 Ser Gly Leu Glu Val Leu Glu Ala Glu Gln Asn Ser Leu His Leu Cys
             100                 105                 110        
 Leu Leu Gly Leu Gly Arg Arg Leu Gln Asp Leu Glu Gln Gly Leu Gly
         115                 120                 125            
 His Trp Ala Leu Ala Gln Ser Gly Met Val Gln Leu Gln Ala Leu Gln
     130                 135                 140                
 Val Asp Leu Arg Gly Ala Ala Glu Arg Val Glu Ala Leu Leu Ala Phe
 145                 150                 155                 160
 Gly Glu Gly Leu Ala Gln Arg Ser Glu Pro Arg Ala Trp Ala Ala Leu
                 165                 170                 175    
 Glu Gln Ile Leu Arg Ala Leu Gly Ala Tyr Arg Asp Ser Ile Phe Arg
             180                 185                 190        
 Arg Leu Trp Gln Leu Gln Ala Gln Leu Val Ser Tyr Ser Leu Val Phe
         195                 200                 205            
 Glu Glu Ala Asn Thr Leu Asp Gln Asp Leu Glu Val Glu Gly Asp Ser
     210                 215                 220                
 Asp Trp Pro Gly Pro Gly Gly Val Trp Gly Pro Trp Ala Pro Ser Ser
 225                 230                 235                 240
 Leu Pro Thr Ser Thr Glu Leu Glu Trp Asp Pro Ala Gly Asp Ile Gly
                 245                 250                 255    
 Gly Leu Gly Pro Leu Gly Gln Lys Thr Ala Arg Thr Leu Gly Val Pro
             260                 265                 270        
 Cys Glu Leu Cys Gly His Arg Gly Pro Gln Gly Arg Gly Gln Gly Leu
         275                 280                 285            
 Glu Glu Ala Asp Thr Ser His Ser Arg Gln Asp Met Leu Glu Ser Gly
     290                 295                 300                
 Leu Gly His Gln Lys Arg Leu Ala Arg His Gln Arg His Ser Leu Leu
 305                 310                 315                 320
 Arg Lys Pro Gln Asp Lys Lys Arg Gln Ala Ser Pro His Leu Gln Asp
                 325                 330                 335    
 Val Arg Leu Glu Gly Asn Pro Gly Ala Pro Asp Pro Ala Ser Arg Gln
             340                 345                 350        
 Pro Leu Thr Phe Leu Leu Ile Leu Phe Leu Leu Phe Leu Leu Leu Val
         355                 360                 365            
 Gly Ala Met Phe Leu Leu Pro Ala Ser Gly Gly Pro Cys Cys Ser His
     370                 375                 380                
 Ala Arg Ile Pro Arg Thr Pro Tyr Leu Val Leu Ser Tyr Val Asn Gly
 385                 390                 395                 400
 Leu Pro Pro Val
                



      <210> 451
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 451
 Met His His Arg Asn Asp Ser Gln Arg Leu Gly Lys Ala Gly Cys Pro
   1               5                  10                  15    
 Pro Glu Pro Ser Leu Gln Met Ala Asn Thr Asn Phe Leu Ser Thr Leu
              20                  25                  30        
 Ser Pro Glu His Cys Arg Pro Leu Ala Gly Glu Cys Met Asn Lys Leu
          35                  40                  45            
 Lys Cys Gly Ala Ala Glu Ala Glu Ile Met Asn Leu Pro Glu Arg Val
      50                  55                  60                
 Gly Thr Phe Ser Ala Ile Pro Ala Leu Gly Gly Ile Ser Leu Pro Pro
  65                  70                  75                  80
 Gly Val Ile Val Met Thr Ala Leu His Ser Pro Ala Ala Ala Ser Ala
                  85                  90                  95    
 Ala Val Thr Asp Ser Ala Phe Gln Ile Ala Asn Leu Ala Asp Cys Pro
             100                 105                 110        
 Gln Asn His Ser Ser Ser Ser Ser Ser Ser Ser Gly Gly Ala Gly Gly
         115                 120                 125            
 Ala Asn Pro Ala Lys Lys Lys Arg Lys Arg Cys Gly Val Cys Val Pro
     130                 135                 140                
 Cys Lys Arg Leu Ile Asn Cys Gly Val Cys Ser Ser Cys Arg Asn Arg
 145                 150                 155                 160
 Lys Thr Gly His Gln Ile Cys Lys Phe Arg Lys Cys Glu Glu Leu Lys
                 165                 170                 175    
 Lys Lys Pro Gly Thr Ser Leu Glu Arg Thr Pro Val Pro Ser Ala Glu
             180                 185                 190        
 Ala Phe Arg Trp Phe Phe
         195            



      <210> 452
      <211> 271
      <212> PRT
      <213> Homo sapiens


      <400> 452
 Met Tyr Tyr Ala Val Ser Gln Ala Arg Val Asn Ala Val Pro Gly Thr
   1               5                  10                  15    
 Met Leu Arg Pro Gln Arg Pro Gly Asp Leu Gln Leu Gly Ala Ser Leu
              20                  25                  30        
 Tyr Glu Leu Val Gly Tyr Arg Gln Pro Pro Ser Ser Ser Ser Ser Ser
          35                  40                  45            
 Thr Ser Ser Thr Ser Ser Thr Ser Ser Ser Ser Thr Thr Ala Pro Leu
      50                  55                  60                
 Leu Pro Lys Ala Ala Arg Glu Lys Pro Glu Ala Pro Ala Glu Pro Pro
  65                  70                  75                  80
 Gly Pro Gly Pro Gly Ser Gly Ala His Pro Gly Gly Ser Ala Arg Pro
                  85                  90                  95    
 Asp Ala Lys Glu Glu Gln Gln Gln Gln Leu Arg Arg Lys Ile Asn Ser
             100                 105                 110        
 Arg Glu Arg Lys Arg Met Gln Asp Leu Asn Leu Ala Met Asp Ala Leu
         115                 120                 125            
 Arg Glu Val Ile Leu Pro Tyr Ser Ala Ala His Cys Gln Gly Ala Pro
     130                 135                 140                
 Gly Arg Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr
 145                 150                 155                 160
 Ile Leu Leu Leu Gly Ser Ser Leu Gln Glu Leu Arg Arg Ala Leu Gly
                 165                 170                 175    
 Glu Gly Ala Gly Pro Ala Ala Pro Arg Leu Leu Leu Ala Gly Leu Pro
             180                 185                 190        
 Leu Leu Ala Ala Ala Pro Gly Ser Val Leu Leu Ala Pro Gly Ala Val
         195                 200                 205            
 Gly Pro Pro Asp Ala Leu Arg Pro Ala Lys Tyr Leu Ser Leu Ala Leu
     210                 215                 220                
 Asp Glu Pro Pro Cys Gly Gln Phe Ala Leu Pro Gly Gly Gly Ala Gly
 225                 230                 235                 240
 Gly Pro Gly Leu Cys Thr Cys Ala Val Cys Lys Phe Pro His Leu Val
                 245                 250                 255    
 Pro Ala Ser Leu Gly Leu Ala Ala Val Gln Ala Gln Phe Ser Lys
             260                 265                 270    



      <210> 453
      <211> 1538
      <212> PRT
      <213> Homo sapiens


      <400> 453
 Met Gln Lys Ile Gly Pro Glu Lys Asp Ser Glu Val Gln Thr Ser Val
   1               5                  10                  15    
 Met Ser Leu Gly Leu Thr Asp Val Ser Thr Gly Lys Arg Gln Leu Arg
              20                  25                  30        
 Leu Gly Leu Lys Pro Phe Lys Pro Pro Pro Pro Pro Leu Leu Arg Phe
          35                  40                  45            
 Cys Ser Gln Gly Asp Arg Arg Lys His Gln Arg Asp Glu Val Ser Glu
      50                  55                  60                
 Ser Glu Thr Ser Val Thr Glu Arg Lys Met Glu Ser Gln Arg Ala Val
  65                  70                  75                  80
 Gly Val Trp Gly Ala Gly Gly Thr Thr Tyr Leu Ser His Trp Pro Cys
                  85                  90                  95    
 Leu Cys Ala Pro Gly Pro Lys Pro Gln Lys Asp Ser Val Ser Asp Trp
             100                 105                 110        
 Ala Ile Val Leu Ile Thr Leu Thr Leu Val Ala Ala Ile Val Ser Leu
         115                 120                 125            
 Met Tyr Gly Ile Lys Lys Ala Cys Gln Phe Arg Arg Glu Met Ser Leu
     130                 135                 140                
 Gly Cys Gly Cys Gly Ser Val Thr Pro Tyr Ser Ser His His Glu Gly
 145                 150                 155                 160
 Glu Ala Ala Ser Gln Arg Tyr Ser Cys Gln Met Lys Gly Ala Thr Thr
                 165                 170                 175    
 Phe Gln Glu Tyr Gln Lys Thr Gly Glu Leu Ser Thr Ser Asp His Ile
             180                 185                 190        
 Phe Pro Leu Thr Pro Gly Leu Val Tyr Ser Ile Pro Phe Asp His Ile
         195                 200                 205            
 Val Leu His Ser Gly Gln Arg Pro Pro Glu Leu Pro Lys Ser Thr Glu
     210                 215                 220                
 Ile His Glu Gln Lys Arg His Cys Asn Thr Thr Arg His Ser Lys Pro
 225                 230                 235                 240
 Thr Asp Lys Pro Thr Gly Asn Ser Lys Thr Ile Asp His Lys Ser Ser
                 245                 250                 255    
 Thr Asp Asn His Glu Ala Pro Pro Thr Ser Glu Glu Asn Ser Ser Asn
             260                 265                 270        
 Gln Gly Lys Asp Pro Met Ile Arg Asn Gln Arg Ser Val Asp Pro Ala
         275                 280                 285            
 Asp Ser Thr Thr Thr His Lys Glu Ser Ala Gly Lys Lys His Ile Thr
     290                 295                 300                
 Pro Ala Pro Lys Ser Lys Ile Asn Cys Arg Lys Ser Thr Thr Gly Lys
 305                 310                 315                 320
 Ser Thr Val Thr Arg Lys Ser Asp Lys Thr Gly Arg Pro Leu Glu Lys
                 325                 330                 335    
 Ser Met Ser Thr Leu Asp Lys Thr Ser Thr Ser Ser His Lys Thr Thr
             340                 345                 350        
 Thr Ser Phe His Asn Ser Gly Asn Ser Gln Thr Lys Gln Lys Ser Thr
         355                 360                 365            
 Ser Phe Pro Glu Lys Ile Thr Ala Ala Ser Lys Thr Thr Tyr Lys Thr
     370                 375                 380                
 Thr Gly Thr Pro Glu Glu Ser Glu Lys Thr Glu Asp Ser Arg Thr Thr
 385                 390                 395                 400
 Val Ala Ser Asp Lys Leu Leu Thr Lys Thr Thr Lys Asn Ile Gln Glu
                 405                 410                 415    
 Thr Ile Ser Ala Asn Glu Leu Thr Gln Ser Leu Ala Glu Pro Thr Glu
             420                 425                 430        
 His Gly Gly Arg Thr Ala Asn Glu Asn Asn Thr Pro Ser Pro Ala Glu
         435                 440                 445            
 Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Leu Ser
     450                 455                 460                
 Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr
 465                 470                 475                 480
 Ala Pro Phe Pro Ala Gly Pro Thr Glu Asn Arg Glu Met Thr Ala Asn
                 485                 490                 495    
 Glu Asn Thr Thr Leu Phe Pro Ala Glu Pro Thr Glu His Gly Glu Arg
             500                 505                 510        
 Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu His
         515                 520                 525            
 Gly Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro
     530                 535                 540                
 Thr Glu His Gly Glu Arg Thr Pro Phe Ala Asn Asp Lys Thr Thr Ser
 545                 550                 555                 560
 Ser Ser Ala Glu Ser Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn
                 565                 570                 575    
 Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg
             580                 585                 590        
 Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Gly Pro Thr Glu Asn
         595                 600                 605            
 Arg Glu Thr Thr Ala Asn Glu Lys Thr Thr Leu Ser Pro Val Glu Pro
     610                 615                 620                
 Thr Glu Asn Arg Glu Thr Thr Ala Asn Glu Lys Thr Thr Pro Ser Pro
 625                 630                 635                 640
 Ala Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn Glu Lys
                 645                 650                 655    
 Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro
             660                 665                 670        
 Leu Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn
         675                 680                 685            
 Arg Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro Ser Pro Ala Glu Pro
     690                 695                 700                
 Thr Glu Asn Gly Asp Arg Thr Pro Leu Ala Asn Glu Lys Thr Thr Pro
 705                 710                 715                 720
 Ser Leu Ala Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn
                 725                 730                 735    
 Glu Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Glu Glu Arg
             740                 745                 750        
 Thr Pro Leu Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Glu Pro Thr
         755                 760                 765            
 Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala
     770                 775                 780                
 Gly Pro Thr Glu Asn Arg Glu Met Thr Ala Asn Glu Lys Thr Thr Leu
 785                 790                 795                 800
 Phe Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys
                 805                 810                 815    
 Thr Thr Ser Ser Pro Ala Glu Pro Thr Glu Asn Gly Gln Arg Thr Pro
             820                 825                 830        
 Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His
         835                 840                 845            
 Gly Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Leu Ser Pro Ala
     850                 855                 860                
 Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro
 865                 870                 875                 880
 Phe Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn
                 885                 890                 895    
 Thr Thr Pro Ser Pro Ala Gln Pro Thr Glu Asn Gly Asp Arg Thr Pro
             900                 905                 910        
 Leu Ala Asn Glu Lys Thr Thr Pro Ser Leu Ala Glu Pro Thr Glu Asn
         915                 920                 925            
 Gly Lys Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala
     930                 935                 940                
 Glu Pro Thr Glu His Ala Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr
 945                 950                 955                 960
 Thr Ser Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn
                 965                 970                 975    
 Glu Lys Thr Thr Gln Phe Pro Ala Glu Pro Thr Glu Asn Arg Glu Ser
             980                 985                 990        
 Thr Ala Asn Glu Lys Thr Thr Pro Phe Pro Ala Glu Pro Thr Glu Asn
         995                1000                1005            
 Arg Glu Trp Thr Ala Asn Glu Asn Thr Thr Leu Ser Pro Ala Glu Pro
    1010                1015                1020                
 Thr Glu His Glu Glu Met Thr Pro Leu Ala Asn Glu Lys Thr Thr Leu
1025                1030                1035                1040
 Ser Pro Ala Glu Pro Thr Glu Asn Gly Glu Arg Thr Pro Phe Thr Asn
                1045                1050                1055    
 Glu Lys Thr Thr Pro Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg
            1060                1065                1070        
 Thr Pro Leu Ala Asn Glu Ile Thr Thr Pro Ser Arg Ala Glu Pro Thr
        1075                1080                1085            
 Glu His Gly Glu Arg Ile Ala Asn Glu Lys Ala Thr Pro Ser Pro Ala
    1090                1095                1100                
 Lys Pro Thr Glu His Gly Glu Thr Thr Val Asn Glu Asp Thr Thr Pro
1105                1110                1115                1120
 Ser Ser Ala Glu Pro Thr Glu Asn Gly Glu Arg Thr Pro Leu Ala Asn
                1125                1130                1135    
 Glu Asn Thr Thr Thr Ser Pro Thr Glu Ser Thr Glu His Gly Glu Arg
            1140                1145                1150        
 Thr Ala Asn Glu Lys Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu His
        1155                1160                1165            
 Gly Glu Arg Thr Pro Ser Ala Asn Glu Lys Thr Ile Pro Ser Pro Ala
    1170                1175                1180                
 Lys Pro Thr Glu His Glu Glu Met Thr Pro Ser Ala Asn Glu Asn Thr
1185                1190                1195                1200
 Thr Pro Ser Pro Val Lys Pro Thr Glu His Gly Glu Lys Thr Thr Leu
                1205                1210                1215    
 Ala Asn Glu Lys Ile Thr Leu Ser Pro Glu Gly Pro Thr Glu His Gly
            1220                1225                1230        
 Ala Lys Thr Thr Ser Ala Asn Glu Lys Ile Thr Pro Ser Leu Ala Lys
        1235                1240                1245            
 Pro Thr Glu His Gly Glu Arg Thr Thr Ser Pro Asn Asp Lys Ile Thr
    1250                1255                1260                
 Ser Ser Ala Ala Glu Ser Thr Glu His Arg Asp Arg Ala Thr Ser Ala
1265                1270                1275                1280
 Asn Val Ile Thr Pro Ala Pro Ala Glu Pro Ile Lys His Ala Lys Arg
                1285                1290                1295    
 Thr Thr Leu Ala His Glu Lys Met Thr Gln Val Thr Glu Lys Ser Thr
            1300                1305                1310        
 Glu His Pro Glu Lys Thr Thr Ser Thr Thr Glu Lys Thr Thr Arg Thr
        1315                1320                1325            
 Pro Glu Lys Pro Thr Leu Tyr Ser Glu Lys Thr Ile Cys Thr Lys Gly
    1330                1335                1340                
 Lys Asn Thr Pro Val Pro Glu Lys Pro Thr Glu Asn Leu Gly Asn Thr
1345                1350                1355                1360
 Thr Leu Thr Thr Glu Thr Ile Lys Ala Pro Val Lys Ser Thr Glu Asn
                1365                1370                1375    
 Pro Glu Lys Thr Ala Ala Val Thr Lys Thr Ile Lys Pro Ser Val Lys
            1380                1385                1390        
 Val Thr Gly Asp Lys Ser Leu Thr Thr Thr Ser Ser His Leu Asn Lys
        1395                1400                1405            
 Thr Glu Val Thr His Gln Val Pro Thr Gly Ser Phe Thr Leu Ile Thr
    1410                1415                1420                
 Ser Arg Thr Lys Leu Ser Ser Ile Thr Ser Glu Ala Thr Gly Asn Glu
1425                1430                1435                1440
 Ser His Pro Tyr Leu Asn Lys Asp Gly Ser Gln Lys Gly Ile His Ala
                1445                1450                1455    
 Gly Gln Met Gly Glu Asn Asp Ser Phe Pro Ala Trp Ala Ile Val Ile
            1460                1465                1470        
 Val Val Leu Val Ala Val Ile Leu Leu Leu Val Phe Leu Gly Leu Ile
        1475                1480                1485            
 Phe Leu Val Ser Tyr Met Met Arg Thr Arg Arg Thr Leu Thr Gln Asn
    1490                1495                1500                
 Thr Gln Tyr Asn Asp Ala Glu Asp Glu Gly Gly Pro Asn Ser Tyr Pro
1505                1510                1515                1520
 Val Tyr Leu Met Glu Gln Gln Asn Leu Gly Met Gly Gln Ile Pro Ser
                1525                1530                1535    
 Pro Arg
        



      <210> 454
      <211> 341
      <212> PRT
      <213> Homo sapiens


      <400> 454
 Met Glu Ala Leu Gly Lys Leu Lys Gln Phe Asp Ala Tyr Pro Lys Thr
   1               5                  10                  15    
 Leu Glu Asp Phe Arg Val Lys Thr Cys Gly Gly Ala Thr Val Thr Ile
              20                  25                  30        
 Val Ser Gly Leu Leu Met Leu Leu Leu Phe Leu Ser Glu Leu Gln Tyr
          35                  40                  45            
 Tyr Leu Thr Thr Glu Val His Pro Glu Leu Tyr Val Asp Lys Ser Arg
      50                  55                  60                
 Gly Asp Lys Leu Lys Ile Asn Ile Asp Val Leu Phe Pro His Met Pro
  65                  70                  75                  80
 Cys Ala Tyr Leu Ser Ile Asp Ala Met Asp Val Ala Gly Glu Gln Gln
                  85                  90                  95    
 Leu Asp Val Glu His Asn Leu Phe Lys Gln Arg Leu Asp Lys Asp Gly
             100                 105                 110        
 Ile Pro Val Ser Ser Glu Ala Glu Arg His Glu Leu Gly Lys Val Glu
         115                 120                 125            
 Val Thr Val Phe Asp Pro Asp Ser Leu Asp Pro Asp Arg Cys Glu Ser
     130                 135                 140                
 Cys Tyr Gly Ala Glu Ala Glu Asp Ile Lys Cys Cys Asn Thr Cys Glu
 145                 150                 155                 160
 Asp Val Arg Glu Ala Tyr Arg Arg Arg Gly Trp Ala Phe Lys Asn Pro
                 165                 170                 175    
 Asp Thr Ile Glu Gln Cys Arg Arg Glu Gly Phe Ser Gln Lys Met Gln
             180                 185                 190        
 Glu Gln Lys Asn Glu Gly Cys Gln Val Tyr Gly Phe Leu Glu Val Asn
         195                 200                 205            
 Lys Val Ala Gly Asn Phe His Phe Ala Pro Gly Lys Ser Phe Gln Gln
     210                 215                 220                
 Ser His Val His Val His Asp Leu Gln Ser Phe Gly Leu Asp Asn Ile
 225                 230                 235                 240
 Asn Met Thr His Tyr Ile Gln His Leu Ser Phe Gly Glu Asp Tyr Pro
                 245                 250                 255    
 Gly Ile Val Asn Pro Leu Asp His Thr Asn Val Thr Ala Pro Gln Ala
             260                 265                 270        
 Ser Met Met Phe Gln Tyr Phe Val Lys Val Val Pro Thr Val Tyr Met
         275                 280                 285            
 Lys Val Lys Leu Thr Glu Lys His Arg Ser Phe Thr His Phe Leu Thr
     290                 295                 300                
 Gly Val Cys Ala Ile Ile Gly Gly Met Phe Thr Val Ala Gly Leu Ile
 305                 310                 315                 320
 Asp Ser Leu Ile Tyr His Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp
                 325                 330                 335    
 Leu Gly Lys Thr Thr
             340    



      <210> 455
      <211> 916
      <212> PRT
      <213> Homo sapiens


      <400> 455
 Met Glu Thr Ser Gln Glu Thr Ser Leu Phe Leu Val Lys Ile Leu Glu
   1               5                  10                  15    
 Glu Leu Asp Ser Lys Gln Asn Thr Val Ser Tyr Gln Asp Leu Cys Lys
              20                  25                  30        
 Ser Leu Cys Ala Arg Phe Asp Leu Ser Gln Leu Ala Lys Leu Arg Ser
          35                  40                  45            
 Val Leu Phe Tyr Thr Ala Cys Leu Asp Pro Asn Phe Pro Ala Thr Leu
      50                  55                  60                
 Phe Lys Asp Lys Met Lys Cys Thr Val Asn Asn Gln Gln Ser Lys Lys
  65                  70                  75                  80
 Ile Met Val Ala Ala Asp Ile Val Thr Ile Phe Asn Leu Ile Gln Met
                  85                  90                  95    
 Asn Gly Gly Ala Ala Lys Glu Lys Leu Pro Thr Gly Arg Gln Lys Val
             100                 105                 110        
 Arg Lys Lys Glu Ala Ser Phe Glu Ser Cys Arg Ser Asp Thr Glu Ile
         115                 120                 125            
 Cys Asn Ala Ala Glu Cys Glu Pro Leu Asn Cys Glu Leu Ser Glu Arg
     130                 135                 140                
 Ser Phe Ser Arg Gly Tyr Pro Ile Arg Gln Ser Ser Lys Cys Arg Lys
 145                 150                 155                 160
 Met Asp Cys Lys Asp Cys Pro Gln Phe Val Pro Ala Ser Glu Pro Asn
                 165                 170                 175    
 Phe Leu Leu Gly Val Ser Lys Glu Val Lys Asn Arg Ala Ala Ser Leu
             180                 185                 190        
 Asp Arg Leu Gln Ala Leu Ala Pro Tyr Ser Val Thr Ser Pro Gln Pro
         195                 200                 205            
 Cys Glu Met Gln Arg Thr Tyr Phe Pro Met Asn Ile Glu Asn Glu Ser
     210                 215                 220                
 Ile Ser Asp Gln Asp Ser Leu Pro Ile Asn Gln Ser Ile Lys Glu Thr
 225                 230                 235                 240
 Phe Ile Ser Asn Glu Glu Pro Phe Val Val Gln Ser Cys Val Gln Lys
                 245                 250                 255    
 Arg Asn Ile Phe Lys Glu Asp Phe His Asn Leu Met Ala Val Ser Pro
             260                 265                 270        
 Ser Leu Val Gly Pro Ile Ser Lys Ala Glu Asn Glu His Arg Glu Pro
         275                 280                 285            
 Gln Ser Arg Lys Glu Pro His Lys Pro Pro Phe Phe Asn His Ser Phe
     290                 295                 300                
 Glu Met Pro Tyr Asn Ser Gln Tyr Leu Asn Pro Val Tyr Ser Pro Val
 305                 310                 315                 320
 Pro Asp Lys Arg Arg Ala Lys His Glu Ser Leu Asp Asp Leu Gln Ala
                 325                 330                 335    
 Ser Thr Tyr Phe Gly Pro Thr Pro Val Met Gly Thr Gln Glu Ala Arg
             340                 345                 350        
 Arg Cys Leu Gly Lys Pro Asn Lys Gln Thr Pro Trp Pro Ala Lys Ser
         355                 360                 365            
 Trp Ser Leu Asn Thr Glu Glu Val Pro Asp Phe Glu Arg Ser Phe Phe
     370                 375                 380                
 Asn Arg Asn Pro Ser Glu Glu Lys Leu His Tyr Pro Asn Ala Ser Ser
 385                 390                 395                 400
 Gln Thr Pro Asn Phe Pro Ala Pro Glu Arg Arg Pro Thr Tyr Leu Val
                 405                 410                 415    
 Pro Lys Asp Gln Gln Pro Ile Leu Pro Ile Ala Tyr Ala Ala Lys Gln
             420                 425                 430        
 Asn Gly Leu Lys Ser Lys Glu Ile Ser Ser Pro Val Asp Leu Glu Lys
         435                 440                 445            
 His Glu Pro Val Lys Lys Phe Lys Asp Lys Ser Ile Asn Cys Thr Ser
     450                 455                 460                
 Gly Gln Leu Ser Ser Asp Thr Ser Ser Val Gly Thr Gln Thr Glu His
 465                 470                 475                 480
 Val Leu Glu Pro Lys Lys Cys Arg Asp Leu Cys Thr Ser Gly Gln Gly
                 485                 490                 495    
 Lys Tyr Ser Asp Arg His Thr Met Lys His Ser Asp Asp Asp Ser Glu
             500                 505                 510        
 Ile Val Ser Asp Asp Ile Ser Asp Ile Phe Arg Phe Leu Asp Asp Met
         515                 520                 525            
 Ser Ile Ser Gly Ser Thr Gly Val Ile Gln Ser Ser Cys Tyr Asn Ser
     530                 535                 540                
 Thr Gly Ser Leu Ser Gln Leu His Lys Ser Asp Cys Asp Ser Ser Pro
 545                 550                 555                 560
 Glu His Asn Leu Thr Lys Ile Ala Asn Gly Val Pro Asn Ser Lys Gly
                 565                 570                 575    
 Asp Lys Gly Asn Arg Pro Glu Asn Thr His His Ser Glu Glu Glu Leu
             580                 585                 590        
 Lys Thr Ser Val Cys Lys Leu Val Leu Arg Ile Gly Glu Ile Glu Arg
         595                 600                 605            
 Lys Leu Glu Ser Leu Ser Gly Val Arg Asp Glu Ile Ser Gln Val Leu
     610                 615                 620                
 Gly Lys Leu Asn Lys Leu Asp Gln Lys Met Gln Gln Pro Glu Lys Val
 625                 630                 635                 640
 Ser Val Gln Ile Asp Leu Asn Ser Leu Thr Ser Glu Gly Pro Ser Asp
                 645                 650                 655    
 Asp Ser Ala Ser Pro Arg Met Phe His Ala His Ser Gly Ser His Gly
             660                 665                 670        
 Pro Lys Leu Glu Asn Asn Pro Asp Trp Cys Cys Ser Asp Ala Ser Gly
         675                 680                 685            
 Ser Asn Ser Glu Ser Leu Arg Val Lys Ala Leu Lys Lys Ser Leu Phe
     690                 695                 700                
 Thr Arg Pro Ser Ser Arg Ser Leu Thr Glu Glu Asn Ser Ala Thr Glu
 705                 710                 715                 720
 Ser Lys Ile Ala Ser Ile Ser Asn Ser Pro Arg Asp Trp Arg Thr Ile
                 725                 730                 735    
 Thr Tyr Thr Asn Arg Val Gly Leu Asn Glu Glu Glu Ile Lys Asp Thr
             740                 745                 750        
 Gly Pro Gly Asp Asn Lys Asp Trp His Arg Lys Ser Lys Glu Ala Asp
         755                 760                 765            
 Arg Gln Tyr Asp Ile Pro Pro Gln His Arg Leu Pro Lys Gln Pro Lys
     770                 775                 780                
 Asp Gly Phe Leu Val Glu Gln Val Phe Ser Pro His Pro Tyr Pro Ala
 785                 790                 795                 800
 Ser Leu Lys Ala His Met Lys Ser Asn Pro Leu Tyr Thr Asp Met Arg
                 805                 810                 815    
 Leu Thr Glu Leu Ala Glu Val Lys Arg Gly Gln Pro Ser Trp Thr Ile
             820                 825                 830        
 Glu Glu Tyr Ala Arg Asn Ala Gly Asp Lys Gly Lys Leu Thr Ala Leu
         835                 840                 845            
 Asp Leu Gln Thr Gln Glu Ser Leu Asn Pro Asn Asn Leu Glu Tyr Trp
     850                 855                 860                
 Met Glu Asp Ile Tyr Thr Pro Gly Tyr Asp Ser Leu Leu Lys Arg Lys
 865                 870                 875                 880
 Glu Ala Glu Phe Arg Arg Ala Lys Val Cys Lys Ile Ala Ala Leu Ile
                 885                 890                 895    
 Ala Ala Ala Ala Cys Thr Val Ile Leu Val Ile Val Val Pro Ile Cys
             900                 905                 910        
 Thr Met Lys Ser
         915    



      <210> 456
      <211> 62
      <212> PRT
      <213> Homo sapiens


      <400> 456
 Met Arg Lys Ile Arg His Arg Glu Val Lys Val Gly Thr Asp Pro Asn
   1               5                  10                  15    
 Ser His Lys Ile Met Thr Ser Pro Ala Phe Lys Leu Ile Ile Lys Gly
              20                  25                  30        
 Trp Ala Gly Phe Val Leu Leu Tyr Val Ser Gly Asn Leu Tyr Leu Leu
          35                  40                  45            
 His Phe Pro Phe Ser Gln Asn Lys Ser His Asp Cys Asn Val
      50                  55                  60        



      <210> 457
      <211> 120
      <212> PRT
      <213> Homo sapiens


      <400> 457
 Met Gly Phe Tyr Leu Arg Lys Ile Thr Leu Thr Trp Gln Arg Asp Gly
   1               5                  10                  15    
 Glu Glu Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly
              20                  25                  30        
 Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Pro Gly Glu
          35                  40                  45            
 Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Gln Pro
      50                  55                  60                
 Leu Ile Leu Arg Trp Glu Gln Ser Pro Gln Pro Thr Ile Pro Ile Val
  65                  70                  75                  80
 Gly Ile Val Ala Gly Leu Val Val Leu Gly Ala Val Val Thr Gly Ala
                  85                  90                  95    
 Val Val Ala Ala Val Met Trp Arg Lys Lys Ser Ser Asp Arg Asn Arg
             100                 105                 110        
 Gly Ser Tyr Ser Gln Ala Ala Val
         115                 120



      <210> 458
      <211> 235
      <212> PRT
      <213> Homo sapiens


      <400> 458
 Met Val Glu Glu Asn His Thr Met Lys Asn Glu Phe Ile Leu Thr Gly
   1               5                  10                  15    
 Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe
              20                  25                  30        
 Ala Ile Tyr Leu Ile Thr Val Val Gly Asn Ile Ser Leu Val Ala Leu
          35                  40                  45            
 Ile Phe Thr His Cys Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly
      50                  55                  60                
 Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys
  65                  70                  75                  80
 Met Leu Glu Asn Phe Phe Ser Glu Gly Lys Arg Ile Ser Leu Tyr Glu
                  85                  90                  95    
 Cys Ala Val Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys
             100                 105                 110        
 Phe Leu Leu Ala Ala Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn
         115                 120                 125            
 Pro Leu Gln Tyr His Ile Met Met Ser Lys Lys Leu Cys Ile Gln Met
     130                 135                 140                
 Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His Val
 145                 150                 155                 160
 Gly Leu Val Phe Arg Leu Val Phe Cys Gly Ser Asn His Ile Asn His
                 165                 170                 175    
 Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro
             180                 185                 190        
 Tyr Ile Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Val Gln Val
         195                 200                 205            
 Phe Thr Ile Gly Met Ile Ser Ile Gln Lys Asn Thr Ala Lys Leu Glu
     210                 215                 220                
 Val Thr Ser Ser Lys Asp His Ser Ile Lys His
 225                 230                 235



      <210> 459
      <211> 470
      <212> PRT
      <213> Homo sapiens


      <400> 459
 Met Gly Ile Trp Thr Ser Gly Thr Asp Ile Phe Leu Ser Leu Trp Glu
   1               5                  10                  15    
 Ile Tyr Val Ser Pro Arg Ser Pro Gly Trp Met Asp Phe Ile Gln His
              20                  25                  30        
 Leu Gly Val Cys Cys Leu Val Ala Leu Ile Ser Val Gly Leu Leu Ser
          35                  40                  45            
 Val Ala Ala Cys Trp Phe Leu Pro Ser Ile Ile Ala Ala Ala Ala Ser
      50                  55                  60                
 Trp Ile Ile Thr Cys Val Leu Leu Cys Cys Ser Lys His Ala Arg Cys
  65                  70                  75                  80
 Phe Ile Leu Leu Val Phe Leu Ser Cys Gly Leu Arg Glu Gly Arg Asn
                  85                  90                  95    
 Ala Leu Ile Ala Ala Gly Thr Gly Ile Val Ile Leu Gly His Val Glu
             100                 105                 110        
 Asn Ile Phe His Asn Phe Lys Gly Leu Leu Asp Gly Met Thr Cys Asn
         115                 120                 125            
 Leu Arg Ala Lys Ser Phe Ser Ile His Phe Pro Leu Leu Lys Lys Tyr
     130                 135                 140                
 Ile Glu Ala Ile Gln Trp Ile Tyr Gly Leu Ala Thr Pro Leu Ser Val
 145                 150                 155                 160
 Phe Asp Asp Leu Val Ser Trp Asn Gln Thr Leu Ala Val Ser Leu Phe
                 165                 170                 175    
 Ser Pro Ser His Val Leu Glu Ala Gln Leu Asn Asp Ser Lys Gly Glu
             180                 185                 190        
 Val Leu Ser Val Leu Tyr Gln Met Ala Thr Thr Thr Glu Val Leu Ser
         195                 200                 205            
 Ser Leu Gly Gln Lys Leu Leu Ala Phe Ala Gly Leu Ser Leu Val Leu
     210                 215                 220                
 Leu Gly Thr Gly Leu Phe Met Lys Arg Phe Leu Gly Pro Cys Gly Trp
 225                 230                 235                 240
 Lys Tyr Glu Asn Ile Tyr Ile Thr Arg Gln Phe Val Gln Phe Asp Glu
                 245                 250                 255    
 Arg Glu Arg His Gln Gln Arg Pro Cys Val Leu Pro Leu Asn Lys Glu
             260                 265                 270        
 Glu Arg Arg Lys Tyr Val Ile Ile Pro Thr Phe Trp Pro Thr Pro Lys
         275                 280                 285            
 Glu Arg Lys Asn Leu Gly Leu Phe Phe Leu Pro Ile Leu Ile His Leu
     290                 295                 300                
 Cys Ile Trp Val Leu Phe Ala Ala Val Asp Tyr Leu Leu Tyr Arg Leu
 305                 310                 315                 320
 Ile Phe Ser Val Ser Lys Gln Phe Gln Ser Leu Pro Gly Phe Glu Val
                 325                 330                 335    
 His Leu Lys Leu His Gly Glu Lys Gln Gly Thr Gln Asp Ile Ile His
             340                 345                 350        
 Asp Ser Ser Phe Asn Ile Ser Val Phe Glu Pro Asn Cys Ile Pro Lys
         355                 360                 365            
 Pro Lys Phe Leu Leu Ser Glu Thr Trp Val Pro Leu Ser Val Ile Leu
     370                 375                 380                
 Leu Ile Leu Val Met Leu Gly Leu Leu Ser Ser Ile Leu Met Gln Leu
 385                 390                 395                 400
 Lys Ile Leu Val Ser Ala Ser Phe Tyr Pro Ser Val Glu Arg Lys Arg
                 405                 410                 415    
 Ile Gln Tyr Leu His Ala Lys Leu Leu Lys Lys Arg Ser Lys Gln Pro
             420                 425                 430        
 Leu Gly Glu Val Lys Arg Arg Leu Ser Leu Tyr Leu Thr Lys Ile His
         435                 440                 445            
 Phe Trp Leu Pro Val Leu Lys Met Ile Arg Lys Lys Gln Met Asp Met
     450                 455                 460                
 Ala Ser Ala Asp Lys Ser
 465                 470



      <210> 460
      <211> 159
      <212> PRT
      <213> Homo sapiens


      <400> 460
 Met Ala Asp Val Pro Gly Ala Gln Arg Ala Val Pro Gly Asp Gly Pro
   1               5                  10                  15    
 Glu Pro Arg Asp Pro Leu Asp Cys Trp Ala Cys Ala Val Leu Val Thr
              20                  25                  30        
 Ala Gln Asn Leu Leu Val Ala Ala Phe Asn Leu Leu Leu Leu Val Leu
          35                  40                  45            
 Val Leu Gly Thr Ile Leu Leu Pro Ala Val Thr Met Leu Gly Phe Gly
      50                  55                  60                
 Phe Leu Cys His Ser Gln Phe Leu Arg Ser Gln Ala Pro Pro Cys Thr
  65                  70                  75                  80
 Ala His Leu Arg Asp Pro Gly Phe Thr Ala Leu Leu Val Thr Gly Phe
                  85                  90                  95    
 Leu Leu Leu Val Pro Leu Leu Val Leu Ala Leu Ala Ser Tyr Arg Arg
             100                 105                 110        
 Leu Cys Leu Arg Leu Arg Leu Ala Asp Cys Leu Val Pro Tyr Ser Arg
         115                 120                 125            
 Ala Leu Tyr Arg Arg Arg Arg Ala Pro Gln Pro Arg Gln Ile Arg Ala
     130                 135                 140                
 Ser Pro Gly Ser Gln Ala Val Pro Thr Ser Gly Lys Val Trp Val
 145                 150                 155                



      <210> 461
      <211> 238
      <212> PRT
      <213> Homo sapiens


      <400> 461
 Met Glu Ser Leu Ser Glu Leu Gln Asn Pro Leu Leu Pro Arg Ser Pro
   1               5                  10                  15    
 Ala His Leu His Gly Pro Tyr Pro Tyr Pro Glu Thr Pro Pro Ser Trp
              20                  25                  30        
 Ser Cys Gln Glu Lys Leu Tyr Ser Tyr Leu Leu Gly Gly Ala Gly Pro
          35                  40                  45            
 Ala Gly Ala His Gln Leu Leu Asp Pro Gly Ser Leu Gln Leu Ala Val
      50                  55                  60                
 Glu Ala Trp Tyr Arg Pro Ser Cys Leu Leu Gly Arg Asp Lys Val Lys
  65                  70                  75                  80
 Glu Pro Arg Ala Gly Ser Cys Glu Thr Ser Phe Thr Glu Asp Arg Glu
                  85                  90                  95    
 Pro Gln Glu Gly Pro Pro Glu Gln Pro Thr Gly Pro Gly Gln Ala Ala
             100                 105                 110        
 Glu Asn Val Thr Ile Gln Thr Val Ser Tyr Gly Val Gln Glu Glu Leu
         115                 120                 125            
 Arg Asp Gln Glu Asp Asp Gln Glu Glu Glu Glu Ser Asp Ala Thr Ser
     130                 135                 140                
 Thr Glu Ser Glu Ser Glu Asp Asn Phe Leu Thr Leu Pro Pro Arg Asp
 145                 150                 155                 160
 His Leu Gly Leu Thr Leu Phe Ser Met Leu Cys Cys Phe Trp Pro Leu
                 165                 170                 175    
 Gly Ile Ala Ala Phe Tyr Phe Ser Gln Gly Thr Ser Lys Ala Ile Ser
             180                 185                 190        
 Lys Gly Asp Phe Arg Leu Ala Ser Thr Thr Ser Arg Arg Ala Leu Phe
         195                 200                 205            
 Leu Ala Thr Leu Ala Ile Ala Val Gly Ala Gly Leu Tyr Val Ala Val
     210                 215                 220                
 Val Val Ala Leu Ala Ala Tyr Met Ser Gln Asn Gly His Gly
 225                 230                 235            



      <210> 462
      <211> 699
      <212> PRT
      <213> Homo sapiens


      <400> 462
 Met Thr Glu Ser Ser Met Lys Lys Leu Ala Ser Thr Leu Leu Asp Ala
   1               5                  10                  15    
 Ile Thr Asp Lys Asp Pro Leu Val Gln Glu Gln Val Cys Ser Ala Leu
              20                  25                  30        
 Cys Ser Leu Gly Glu Val Arg Pro Val Glu Thr Leu Arg Ala Cys Glu
          35                  40                  45            
 Glu Tyr Leu Arg Gln His Asp Lys Leu Ala His Pro Tyr Arg Ala Ala
      50                  55                  60                
 Val Leu Arg Ala Met Glu Arg Val Leu Ser Ser Arg Ala Ser Glu Leu
  65                  70                  75                  80
 Asp Lys Asp Thr Ala Ser Thr Ile Ile Leu Leu Ala Ser Ser Glu Met
                  85                  90                  95    
 Thr Lys Thr Lys Asp Leu Val Trp Asp Trp Gln Gln Ala Ala Ser Gly
             100                 105                 110        
 Val Leu Val Ala Val Gly Arg Gln Phe Ile Ser Lys Val Met Glu Glu
         115                 120                 125            
 Leu Leu Arg Arg Leu His Pro Gly Thr Leu Pro His Cys Ala Val Leu
     130                 135                 140                
 His Thr Leu Ala Ser Leu Ser Val Ala Asn Ala Phe Gly Val Val Pro
 145                 150                 155                 160
 Phe Leu Pro Ser Val Leu Ser Ser Leu Leu Pro Val Leu Gly Val Ala
                 165                 170                 175    
 Lys Gln Asp Thr Val Arg Val Ala Phe Cys Ser Ala Leu Gln Arg Phe
             180                 185                 190        
 Ser Glu Gly Ala Leu Glu Tyr Leu Ala Asn Leu Asp Arg Ala Pro Asp
         195                 200                 205            
 Pro Thr Val Arg Lys Asp Ala Phe Ala Thr Asp Ile Phe Ser Ala Tyr
     210                 215                 220                
 Asp Val Leu Phe His Gln Trp Leu Gln Ser Arg Glu Ala Lys Leu Arg
 225                 230                 235                 240
 Leu Ala Val Val Glu Ala Leu Gly Pro Met Ser His Leu Leu Pro Ser
                 245                 250                 255    
 Glu Arg Leu Glu Glu Gln Leu Pro Lys Leu Leu Pro Gly Ile Leu Ala
             260                 265                 270        
 Leu Tyr Lys Lys His Ala Glu Thr Phe Tyr Leu Ser Lys Ser Leu Gly
         275                 280                 285            
 Gln Ile Leu Glu Ala Ala Val Ser Val Gly Ser Arg Thr Leu Glu Thr
     290                 295                 300                
 Gln Leu Asp Ala Leu Leu Ala Ala Leu His Ser Gln Ile Cys Val Pro
 305                 310                 315                 320
 Val Glu Ser Ser Ser Pro Leu Val Met Ser Asn Gln Lys Glu Val Leu
                 325                 330                 335    
 Arg Cys Phe Thr Val Leu Ala Cys Ser Ser Pro Asp Arg Leu Leu Ala
             340                 345                 350        
 Phe Leu Leu Pro Arg Leu Asp Thr Ser Asn Glu Arg Thr Arg Val Gly
         355                 360                 365            
 Thr Leu Gln Val Val Arg His Val Ile Asn Ser Ala Ala Ala Gln Met
     370                 375                 380                
 Glu Asp Lys Lys Pro Phe Ile Leu Ser Ser Met Arg Leu Pro Leu Leu
 385                 390                 395                 400
 Asp Thr Asn Ser Lys Val Lys Arg Ala Val Val Gln Val Ile Ser Ala
                 405                 410                 415    
 Met Ala His His Gly Tyr Leu Glu Gln Pro Gly Gly Glu Ala Met Ile
             420                 425                 430        
 Glu Tyr Ile Val Gln Gln Cys Ala Leu Pro Pro Glu Gln Glu Pro Glu
         435                 440                 445            
 Glu Pro Gly Pro Gly Ser Lys Asp Pro Lys Ala Asp Ser Val Arg Ala
     450                 455                 460                
 Ile Ser Val Arg Thr Leu Tyr Leu Val Ser Thr Thr Val Asp Arg Met
 465                 470                 475                 480
 Ser His Val Leu Trp Pro Tyr Leu Leu Gln Phe Leu Thr Pro Val Arg
                 485                 490                 495    
 Phe Thr Gly Ala Leu Thr Pro Leu Cys Arg Ser Leu Val His Leu Ala
             500                 505                 510        
 His Lys Arg Gln Glu Ala Gly Ala Asp Ala Phe Leu Ile Gln Tyr Asp
         515                 520                 525            
 Ala His Ala Ser Leu Pro Ser Pro Tyr Ala Val Thr Gly Arg Leu Leu
     530                 535                 540                
 Val Val Ser Ser Ser Pro Tyr Leu Gly Asp Gly Arg Gly Ala Ala Ala
 545                 550                 555                 560
 Leu Arg Leu Leu Ser Val Leu His Pro Asn Ile His Pro Leu Leu Gly
                 565                 570                 575    
 Gln His Trp Glu Thr Thr Val Pro Leu Leu Leu Gly Tyr Leu Asp Glu
             580                 585                 590        
 His Thr Glu Glu Thr Leu Pro Gln Glu Glu Trp Glu Glu Lys Leu Leu
         595                 600                 605            
 Met Phe Leu Arg Asp Thr Leu Ala Ile Ile Ser Asp Asn Ala Trp Ile
     610                 615                 620                
 Cys Gln Leu Ser Leu Glu Leu Cys Arg Gln Leu Pro Cys Tyr Asp Glu
 625                 630                 635                 640
 Ala Pro Gln Glu Lys Asn Phe Leu Tyr Lys Cys Ile Gly Thr Thr Leu
                 645                 650                 655    
 Gly Ala Val Ser Ser Lys Glu Val Val Arg Lys His Leu Gln Glu Leu
             660                 665                 670        
 Leu Glu Thr Gly Arg Tyr Gln Glu Glu Ala Glu Arg Glu Gly Leu Ala
         675                 680                 685            
 Cys Cys Phe Gly Ile Cys Ala Ile Ser His Leu
     690                 695                



      <210> 463
      <211> 501
      <212> PRT
      <213> Homo sapiens


      <400> 463
 Met Gln Val Ser Phe Asn Thr Ser Asp Arg Ser Gln Thr Val Thr Asp
   1               5                  10                  15    
 Leu Leu Leu Thr Ile Asp Val Thr Glu Val Val Glu Val Gly His Phe
              20                  25                  30        
 Trp Gly Tyr Arg Ile Asp Glu Asn Asn Ser Glu Ile Leu Lys Lys Leu
          35                  40                  45            
 Thr Ala Glu Ile Asn Gln Leu Thr Leu Val Pro Leu Pro Thr His Pro
      50                  55                  60                
 His Pro Asp Leu Val Cys Leu Ala Pro Phe Ala Asp Phe Asp Lys Gln
  65                  70                  75                  80
 Arg Tyr Phe Arg Ala Gln Val Leu Tyr Val Ser Gly Asn Ser Ala Glu
                  85                  90                  95    
 Val Phe Phe Val Asp Tyr Gly Asn Lys Ser His Val Asp Leu His Leu
             100                 105                 110        
 Leu Met Glu Ile Pro Cys Gln Phe Leu Glu Leu Pro Phe Gln Ala Leu
         115                 120                 125            
 Glu Phe Lys Ile Cys Lys Met Arg Pro Ser Ala Lys Ser Leu Val Cys
     130                 135                 140                
 Gly Lys His Trp Ser Asp Gly Ala Ser Gln Trp Phe Ala Ser Leu Val
 145                 150                 155                 160
 Ser Gly Cys Thr Leu Leu Val Lys Val Phe Ser Val Val His Ser Val
                 165                 170                 175    
 Leu His Val Asp Val Tyr Gln Tyr Ser Gly Val Gln Asp Ala Ile Asn
             180                 185                 190        
 Ile Arg Asp Val Leu Ile Gln Gln Gly Tyr Ala Glu Leu Thr Glu Glu
         195                 200                 205            
 Ser Tyr Glu Ser Lys Gln Ser His Glu Val Leu Lys Gly Leu Phe Ser
     210                 215                 220                
 Lys Ser Val Glu Asn Met Thr Asp Gly Ser Val Pro Phe Pro Met Lys
 225                 230                 235                 240
 Asp Asp Glu Lys Tyr Leu Ile Arg Ile Leu Leu Glu Ser Phe Ser Thr
                 245                 250                 255    
 Asn Lys Leu Gly Thr Pro Asn Cys Lys Ala Glu Leu His Gly Pro Phe
             260                 265                 270        
 Asn Pro Tyr Glu Leu Lys Cys His Ser Leu Thr Arg Ile Ser Lys Phe
         275                 280                 285            
 Arg Cys Val Trp Ile Glu Lys Glu Ser Ile Asn Ser Val Ile Ile Ser
     290                 295                 300                
 Asp Ala Pro Glu Asp Leu His Gln Arg Met Leu Val Ala Ala Ser Leu
 305                 310                 315                 320
 Ser Ile Asn Ala Thr Gly Ser Thr Met Leu Leu Arg Glu Thr Ser Leu
                 325                 330                 335    
 Met Pro His Ile Pro Gly Leu Pro Ala Leu Leu Ser Met Leu Phe Ala
             340                 345                 350        
 Pro Val Ile Glu Leu Arg Ile Asp Gln Asn Gly Lys Tyr Tyr Thr Gly
         355                 360                 365            
 Val Leu Cys Gly Leu Gly Trp Asn Pro Ala Thr Gly Ala Ser Ile Leu
     370                 375                 380                
 Pro Glu His Asp Met Glu Leu Ala Phe Asp Val Gln Phe Ser Val Glu
 385                 390                 395                 400
 Asp Val Val Glu Val Asn Ile Leu Arg Ala Ala Ile Asn Lys Leu Val
                 405                 410                 415    
 Cys Asp Gly Pro Asn Gly Cys Lys Cys Leu Gly Pro Glu Arg Val Ala
             420                 425                 430        
 Gln Leu Gln Asp Ile Ala Arg Gln Lys Leu Leu Gly Leu Phe Cys Gln
         435                 440                 445            
 Ser Lys Pro Arg Glu Lys Ile Val Pro Lys Trp His Glu Lys Pro Tyr
     450                 455                 460                
 Glu Trp Asn Gln Val Asp Pro Lys Leu Val Met Glu Gln Ala Asp Arg
 465                 470                 475                 480
 Glu Ser Ser Arg Gly Lys Asn Thr Phe Leu Tyr Gln Leu His Lys Leu
                 485                 490                 495    
 Val Val Leu Gly Thr
             500    



      <210> 464
      <211> 749
      <212> PRT
      <213> Homo sapiens


      <400> 464
 Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu
   1               5                  10                  15    
 Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His
              20                  25                  30        
 Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp
          35                  40                  45            
 His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val
      50                  55                  60                
 Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg
  65                  70                  75                  80
 Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp
                  85                  90                  95    
 Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys
             100                 105                 110        
 Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser
         115                 120                 125            
 Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr
     130                 135                 140                
 Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu
 145                 150                 155                 160
 Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val
                 165                 170                 175    
 Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala
             180                 185                 190        
 Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr
         195                 200                 205            
 Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly
     210                 215                 220                
 Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg
 225                 230                 235                 240
 Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys
                 245                 250                 255    
 Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro
             260                 265                 270        
 Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly
         275                 280                 285            
 Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser
     290                 295                 300                
 Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val
 305                 310                 315                 320
 Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly
                 325                 330                 335    
 Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro
             340                 345                 350        
 Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp
         355                 360                 365            
 Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn
     370                 375                 380                
 Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val
 385                 390                 395                 400
 Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly
                 405                 410                 415    
 Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro
             420                 425                 430        
 Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly
         435                 440                 445            
 Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln
     450                 455                 460                
 Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val
 465                 470                 475                 480
 Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu
                 485                 490                 495    
 Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu
             500                 505                 510        
 Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro
         515                 520                 525            
 Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly
     530                 535                 540                
 Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu
 545                 550                 555                 560
 Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg
                 565                 570                 575    
 Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala
             580                 585                 590        
 Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala
         595                 600                 605            
 Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser
     610                 615                 620                
 Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu
 625                 630                 635                 640
 Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu
                 645                 650                 655    
 Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser
             660                 665                 670        
 Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro
         675                 680                 685            
 His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro
     690                 695                 700                
 Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu
 705                 710                 715                 720
 Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro
                 725                 730                 735    
 Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp
             740                 745                



      <210> 465
      <211> 460
      <212> PRT
      <213> Homo sapiens


      <400> 465
 Met Ala Val Tyr Ser Val Gly Lys His Leu Phe Val Ser Gln Arg Lys
   1               5                  10                  15    
 Lys Ile Glu Arg Leu Val Ser Arg Glu Lys Phe Gly Ser Gln Leu Gly
              20                  25                  30        
 Phe Met Cys Glu Val Lys Lys Glu Val Glu Leu Leu Thr Asp Phe Leu
          35                  40                  45            
 Cys Phe Leu Glu Ile Tyr Gln Arg Arg Arg Leu Arg Val Val Leu Glu
      50                  55                  60                
 Val Thr Gly Leu Asp Thr Cys Tyr Pro Glu Arg Val Val Gly Val Leu
  65                  70                  75                  80
 Asn Ala Ile Asn Thr Leu Leu Ser Asp Ser His Ala Pro Phe Ile Phe
                  85                  90                  95    
 Ile Leu Val Val Asp Pro Ser Ile Leu Ala Ala Cys Leu Glu Ser Ala
             100                 105                 110        
 Gly Asn Met Lys Gly Thr Ala Asp Asn Gly Tyr Leu Phe Leu Asn Arg
         115                 120                 125            
 Thr Val Thr Leu Pro Phe Ser Val Pro Ile Met Gly Arg Arg Thr Lys
     130                 135                 140                
 Leu Gln Phe Leu His Asp Ala Val Gln Ser Arg Asp Asp Leu Leu Tyr
 145                 150                 155                 160
 Arg Glu Met Thr Arg Lys Pro Trp Leu Pro Gly Asp Ala Gly Gly Glu
                 165                 170                 175    
 Ser Ala Gln Leu Leu Ala Val Gln Ala Gln Ala Gly Thr Glu Arg Gly
             180                 185                 190        
 Gln Gly Arg Ile Asp Asp Glu Ala Ala Arg Arg Ile Gln Glu Ala Leu
         195                 200                 205            
 Phe Cys Leu His Asp Glu Arg Asp Cys Leu Tyr Glu Tyr Val Pro Asp
     210                 215                 220                
 Asn Val Val Ser Met Arg Arg Ile Val Asn Thr Val Pro Ile Thr Val
 225                 230                 235                 240
 Arg Leu Leu Gln Gln Gln Gln Gln Gln Gly Asp Phe Gly Gly Pro Thr
                 245                 250                 255    
 Pro Arg Gln Ala Val Ala Trp Val Val Leu Ala Asn Gln Trp Pro Cys
             260                 265                 270        
 Arg Leu Ser Trp Ala Leu Gln Cys Leu Glu Asp Arg Gln Gln Thr Gly
         275                 280                 285            
 Gly Ala Pro Glu Gly Arg Ala Arg Leu Trp Asp Val Phe Arg Asp Asn
     290                 295                 300                
 Ser Arg Glu Leu His Thr Met Thr Lys Ala Leu Gln Asn Val Leu Asp
 305                 310                 315                 320
 Leu Asp Gly Asp Pro Glu Leu Phe Glu Arg Phe Leu Gly Ala Asp Phe
                 325                 330                 335    
 Pro Phe Thr Val Ala Glu Ala Gln Ser Leu Leu Arg Cys Thr Val Asn
             340                 345                 350        
 Leu Asp His Ser Ile Arg Arg Arg Met Gly Leu Ile Arg Ala Val Ser
         355                 360                 365            
 Ala Leu Lys Pro Pro Ser Pro Pro Lys Ser Pro Thr Arg Asp Thr Pro
     370                 375                 380                
 His Ala Ala His Arg Ala Asn Ser Ala Ser Arg Ala Pro Pro Ser Gly
 385                 390                 395                 400
 Arg Ala Ser Gly Gln Ala Gly Glu Gly His His Thr Gly Asp Leu Ala
                 405                 410                 415    
 His Arg Gly Lys Leu Trp Pro Val Ala Cys Ala Leu Phe Arg Pro Gly
             420                 425                 430        
 Gln Ser Ser Pro Gly Tyr Leu Pro Tyr Glu Ser Leu Gln Gly His Trp
         435                 440                 445            
 Leu Val Thr Asp Thr Glu Ala Thr Ala Ser Ala Pro
     450                 455                 460



      <210> 466
      <211> 467
      <212> PRT
      <213> Homo sapiens


      <400> 466
 Met Lys Asp Asn Ser Ser Ser Ser Ser Thr Asp Ser Arg Ser Arg Ser
   1               5                  10                  15    
 Ser Ser Arg Ser Pro Thr Arg His Phe Arg Arg Ser Asp Ser His Ser
              20                  25                  30        
 Asp Ser Asp Ser Ser Tyr Ser Gly Asn Glu Cys His Pro Val Gly Arg
          35                  40                  45            
 Arg Asn Pro Pro Pro Lys Gly Arg Gly Gly Arg Gly Ala His Met Asp
      50                  55                  60                
 Arg Gly Arg Gly Arg Ala Gln Arg Gly Lys Arg His Asp Leu Ala Pro
  65                  70                  75                  80
 Thr Lys Arg Ser Arg Lys Lys Met Ala Ala Leu Glu Cys Glu Asp Pro
                  85                  90                  95    
 Glu Arg Glu Leu Lys Lys Gln Lys Arg Ala Ala Arg Phe Gln His Gly
             100                 105                 110        
 His Ser Arg Arg Leu Arg Leu Glu Pro Leu Val Leu Gln Met Ser Ser
         115                 120                 125            
 Leu Glu Ser Ser Gly Ala Asp Pro Asp Trp Gln Glu Leu Gln Ile Val
     130                 135                 140                
 Gly Thr Cys Pro Asp Ile Thr Lys His Tyr Leu Arg Leu Thr Cys Ala
 145                 150                 155                 160
 Pro Asp Pro Ser Thr Val Arg Pro Val Ala Val Leu Lys Lys Ser Leu
                 165                 170                 175    
 Cys Met Val Lys Cys His Trp Lys Glu Lys Gln Asp Tyr Ala Phe Ala
             180                 185                 190        
 Cys Glu Gln Met Lys Ser Ile Arg Gln Asp Leu Thr Val Gln Gly Ile
         195                 200                 205            
 Arg Thr Glu Phe Thr Val Glu Val Tyr Glu Thr His Ala Arg Ile Ala
     210                 215                 220                
 Leu Glu Lys Gly Asp His Glu Glu Phe Asn Gln Cys Gln Thr Gln Leu
 225                 230                 235                 240
 Lys Ser Leu Tyr Ala Glu Asn Leu Pro Gly Asn Val Gly Glu Phe Thr
                 245                 250                 255    
 Ala Tyr Arg Ile Leu Tyr Tyr Ile Phe Thr Lys Asn Ser Gly Asp Ile
             260                 265                 270        
 Thr Thr Glu Leu Ala Tyr Leu Thr Arg Glu Leu Lys Ala Asp Pro Cys
         275                 280                 285            
 Val Ala His Ala Leu Ala Leu Arg Thr Ala Trp Ala Leu Gly Asn Tyr
     290                 295                 300                
 His Arg Phe Phe Arg Leu Tyr Cys His Ala Pro Cys Met Ser Gly Tyr
 305                 310                 315                 320
 Leu Val Asp Lys Phe Ala Asp Arg Glu Arg Lys Val Ala Leu Lys Ala
                 325                 330                 335    
 Met Ile Lys Thr Tyr Val Val Pro Ser Ser Leu Leu Pro Leu Leu Phe
             340                 345                 350        
 Pro Ser Phe Arg Leu Ala Pro Pro Leu Arg Pro Ala Pro Gly Arg Arg
         355                 360                 365            
 Pro Pro Pro Ala Pro Asn Pro Cys Pro Gly Pro Cys Phe Pro Ile Ile
     370                 375                 380                
 Phe Leu His Ser Ala Leu Pro Ser Pro Val Pro Leu Ala Leu Leu Val
 385                 390                 395                 400
 Gly His Leu Cys Val Pro Gly His Ser Ser Pro Ser Pro His Cys Ser
                 405                 410                 415    
 Gln Leu Thr Ala Ser Gly Ala Ser Ser Pro Pro His Leu Cys Val Ser
             420                 425                 430        
 Ser Ser Cys Ser Leu Leu Pro Gly Pro Pro Ser Ser Leu Leu Ala Leu
         435                 440                 445            
 Gly Phe Leu Arg Thr Leu Arg Ser Leu Leu Ser Gln Leu Val Ala Val
     450                 455                 460                
 Leu Pro Pro
 465        



      <210> 467
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 467
 Met Phe Pro Arg Cys Thr Asp Leu Leu Gly Lys Thr Arg Glu Gly His
   1               5                  10                  15    
 Pro Arg Thr Pro Ala Leu Pro Gly Arg Ala Ser Pro Arg Ile Ala Ser
              20                  25                  30        
 Trp Pro Leu Glu Pro Ser Leu Cys Ile Leu Cys Cys Ser Ser Leu Gly
          35                  40                  45            
 Leu His Leu Gly Cys Gly Leu Asp Thr Leu Ala Arg Cys Phe Pro Ser
      50                  55                  60                
 Leu Lys Asp His Ser Pro Ala Leu Pro Val Val Arg Cys Leu Glu Thr
  65                  70                  75                  80
 Ile Val Phe Phe Gly Leu Ile Leu
                  85            



      <210> 468
      <211> 584
      <212> PRT
      <213> Homo sapiens


      <400> 468
 Met Phe Glu Ala Leu Gly Asp Pro Glu Lys Asn Cys Ser Arg Ala Ala
   1               5                  10                  15    
 Thr Val Met Ile Asn Cys Leu Leu Gln Glu Arg Gly Gly Val Leu Gln
              20                  25                  30        
 Glu Lys Val Pro Glu Ile Val Ser Val Leu Arg Ser Lys Leu Gln Glu
          35                  40                  45            
 Ala Gln Gly Glu His Val Leu Pro Ala Ala Gln His Ser Val Tyr Leu
      50                  55                  60                
 Leu Ala Thr Gln His Cys Ala Ala Val Val Ser Ser Leu Leu Gly Ser
  65                  70                  75                  80
 Pro Leu Pro Leu Asp Ser His Thr Cys Met Leu Trp Arg Ala Leu Ala
                  85                  90                  95    
 Val Glu Pro Arg Leu Ala Ala Gln Val Leu Gly Leu Leu Leu Glu Lys
             100                 105                 110        
 Met Ser Arg Asp Val Pro Phe Lys Glu Ser Arg Ala Phe Leu Leu Gly
         115                 120                 125            
 Arg Thr Pro Asp Arg Val Ala Thr Leu Leu Pro Leu Ser Ala Thr Cys
     130                 135                 140                
 Ala Leu Phe Glu Val Met Ser Thr Pro Ala Ala Gly Pro Ala Val Leu
 145                 150                 155                 160
 Glu Leu Tyr Pro Gln Leu Phe Val Val Leu Leu Leu Arg Val Ser Cys
                 165                 170                 175    
 Thr Val Gly Val Gln Leu Pro Arg Asn Leu Gln Ala Gln Glu Arg Arg
             180                 185                 190        
 Gly Ala Ser Pro Ala Leu Ala Thr Arg Asn Leu Glu Pro Cys Ser Ser
         195                 200                 205            
 Ala Val Asp Thr Leu Arg Ser Met Leu Leu Arg Ser Gly Ser Glu Asp
     210                 215                 220                
 Val Val Gln Arg Met Asp Leu Glu Gly Gly Trp Glu Leu Leu Arg Thr
 225                 230                 235                 240
 Ser Ala Gly His Glu Glu Gly Ala Thr Arg Leu Ala Arg Ala Met Ala
                 245                 250                 255    
 Glu His Ala Gly Pro Arg Leu Pro Leu Val Leu Lys Thr Leu Ala Cys
             260                 265                 270        
 Thr His Ser Ser Ala Tyr Glu Asn Gln Arg Val Thr Thr Thr Ala Phe
         275                 280                 285            
 Leu Ala Glu Leu Leu Asn Ser Asn Val Ala Asn Asp Leu Met Leu Leu
     290                 295                 300                
 Asp Ser Leu Leu Glu Ser Leu Ala Ala Arg Gln Lys Asp Thr Cys Ala
 305                 310                 315                 320
 Ser Val Arg Arg Leu Val Leu Arg Gly Leu Ala Asn Leu Ala Ser Gly
                 325                 330                 335    
 Cys Pro Asp Lys Val Arg Thr His Gly Pro Gln Leu Leu Thr Ala Met
             340                 345                 350        
 Ile Gly Gly Leu Asp Asp Gly Asp Asn Pro His Ser Pro Val Ala Leu
         355                 360                 365            
 Glu Ala Met Leu Gly Leu Ala Arg Leu Val His Leu Val Glu Ser Trp
     370                 375                 380                
 Asp Leu Arg Ser Gly Leu Leu His Val Ala Ile Arg Ile Arg Pro Phe
 385                 390                 395                 400
 Phe Asp Ser Glu Lys Met Glu Phe Arg Thr Ala Ser Ile Arg Leu Phe
                 405                 410                 415    
 Gly His Leu Asn Lys Val Cys His Gly Asp Cys Glu Asp Val Phe Leu
             420                 425                 430        
 Asp Gln Val Val Gly Gly Leu Ala Pro Leu Leu Leu His Leu Gln Asp
         435                 440                 445            
 Pro Gln Ala Thr Val Ala Ser Ala Cys Arg Phe Ala Leu Arg Met Cys
     450                 455                 460                
 Gly Pro Asn Leu Ala Cys Glu Glu Leu Ser Ala Ala Phe Gln Lys His
 465                 470                 475                 480
 Leu Gln Glu Gly Arg Ala Leu His Phe Gly Glu Phe Leu Asn Thr Thr
                 485                 490                 495    
 Cys Lys His Leu Met His His Phe Pro Asp Leu Leu Gly Arg Leu Leu
             500                 505                 510        
 Thr Thr Cys Leu Phe Tyr Phe Lys Ser Ser Trp Glu Asn Val Arg Ala
         515                 520                 525            
 Ala Ala Pro Leu Phe Thr Gly Phe Leu Val Leu His Ser Glu Pro Arg
     530                 535                 540                
 Gln Gln Pro Gln Val Asp Leu Asp Gln Leu Ile Ala Ala Leu Gln Ile
 545                 550                 555                 560
 Leu Leu Lys Asp Pro Ala Pro Glu Val Arg Thr Arg Ala Ala Glu Ala
                 565                 570                 575    
 Leu Gly Arg Leu Val Lys Leu Ala
             580                



      <210> 469
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 469
 Met Cys Arg Cys Pro Pro Glu His His Asp Gly Arg Met Thr Ser Ala
   1               5                  10                  15    
 Glu Val Gly Ala Ala Ala Gly Gly Ala Gln Ala Ala Gly Pro Pro Glu
              20                  25                  30        
 Trp Pro Pro Gly Ser Pro Gln Ala Leu Arg Gln Pro Gly Arg Ala Arg
          35                  40                  45            
 Val Ala Met Ala Ala Leu Val Trp Leu Leu Ala Gly Ala Ser Met Ser
      50                  55                  60                
 Ser Leu Asn Lys Trp Ile Phe Thr Val His Gly Phe Gly Arg Pro Leu
  65                  70                  75                  80
 Leu Leu Ser Ala Leu His Met Leu Val Ala Ala Leu Ala Cys His Arg
                  85                  90                  95    
 Gly Ala Arg Arg Pro Met Pro Gly Gly Thr Arg Cys Arg Val Leu Leu
             100                 105                 110        
 Leu Ser Leu Thr Phe Gly Thr Ser Met Ala Cys Gly Asn Val Gly Leu
         115                 120                 125            
 Arg Ala Val Pro Leu Asp Leu Ala Gln Leu Val Thr Thr Thr Thr Pro
     130                 135                 140                
 Leu Phe Thr Leu Ala Leu Ser Ala Leu Leu Leu Gly Arg Arg His His
 145                 150                 155                 160
 Pro Leu Gln Leu Ala Ala Met Gly Pro Leu Cys Leu Gly Ala Ala Cys
                 165                 170                 175    
 Ser Leu Ala Gly Glu Phe Arg Thr Pro Pro Thr Gly Cys Gly Phe Leu
             180                 185                 190        
 Leu Ala Ala Thr Cys Leu Arg Gly Leu Lys Ser Val Gln Gln Ser Ala
         195                 200                 205            
 Leu Leu Gln Glu Glu Arg Leu Asp Ala Val Thr Leu Leu Tyr Ala Thr
     210                 215                 220                
 Ser Leu Pro Ser Phe Cys Leu Leu Ala Gly Ala Ala Leu Val Leu Glu
 225                 230                 235                 240
 Ala Gly Val Ala Pro Pro Pro Thr Ala Gly Asp Ser Arg Leu Trp Ala
                 245                 250                 255    
 Cys Ile Leu Leu Ser Cys Leu Leu Ser Val Leu Tyr Asn Leu Ala Ser
             260                 265                 270        
 Phe Ser Leu Leu Ala Leu Thr Ser Ala Leu Thr Val His Val Leu Gly
         275                 280                 285            
 Asn Leu Thr Val Val Gly Asn Leu Ile Leu Ser Arg Leu Leu Phe Gly
     290                 295                 300                
 Ser Arg Leu Ser Ala Leu Ser Tyr Val Gly Ile Ala Leu Thr Leu Ser
 305                 310                 315                 320
 Gly Met Phe Leu Tyr His Asn Cys Glu Phe Val Ala Ser Trp Ala Ala
                 325                 330                 335    
 Arg Arg Gly Leu Trp Arg Arg Asp Gln Pro Ser Lys Gly Leu
             340                 345                 350



      <210> 470
      <211> 663
      <212> PRT
      <213> Homo sapiens


      <400> 470
 Met Ala Val Ser Thr Glu Thr Ala Asp Trp Leu Gly Pro Cys Asn Ser
   1               5                  10                  15    
 Ala Gln Leu Glu Arg Lys Ile Trp Gly Lys Ala Arg Leu Pro Ala Gln
              20                  25                  30        
 Arg Arg Leu Cys Ala Lys Trp Gln Thr Leu Gly Glu Ser Arg Arg Gly
          35                  40                  45            
 Ala Asp Pro Ser Ala Ser Ser Asp Arg Gly Glu Arg Arg Arg Glu Thr
      50                  55                  60                
 Pro Ala Gly Gly Arg Ala Gly Pro Trp Leu Val Gln Thr Ala Ala Gly
  65                  70                  75                  80
 Lys His Arg Gly Asp Thr His Leu Glu Arg Ala Pro Gly Arg His Phe
                  85                  90                  95    
 Arg Phe Arg Pro Ser Gly Ser Arg Gly Glu Ala Ala Ala Ala Ala Ile
             100                 105                 110        
 Thr Thr Val Gly Ser Leu Thr Trp Leu Pro Pro Arg Asp Pro Ser Pro
         115                 120                 125            
 Tyr Leu Gly Phe Ala Pro Ala Lys Trp Ala Gln Pro Trp Leu Leu Arg
     130                 135                 140                
 Pro Val Ala Ala Thr Ser Ile Ala Leu Leu Ser Leu Arg Ala Leu Gly
 145                 150                 155                 160
 Val Ala Gln Gly Gly Thr Trp Val Asn Gly Ser Gly Ser Ser Leu Ser
                 165                 170                 175    
 Ser Pro Gly Gly Ala Ser Pro Glu Ala Asp Leu Pro Arg Val Pro Thr
             180                 185                 190        
 Ile Ala Leu Leu Ser Gly Leu Ser Leu Gln Pro Val Val Ala Gly Gly
         195                 200                 205            
 Gly Met Val Phe Cys Leu Ser Ser Glu Glu Pro Arg Arg Pro Leu Arg
     210                 215                 220                
 Ser Asp Met Val His Phe Gln Ala Ser Glu Val Gln Gln Leu Leu His
 225                 230                 235                 240
 Asn Lys Phe Val Val Ile Leu Gly Asp Ser Ile Gln Arg Ala Val Tyr
                 245                 250                 255    
 Lys Asp Leu Val Leu Leu Leu Gln Lys Asp Ser Leu Leu Thr Ala Ala
             260                 265                 270        
 Gln Leu Lys Ala Lys Gly Glu Leu Ser Phe Glu Gln Asp Gln Leu Val
         275                 280                 285            
 Ala Gly Gly Gln Leu Gly Glu Leu His Asn Gly Thr Gln Tyr Arg Glu
     290                 295                 300                
 Val Arg Gln Phe Cys Ser Gly Ser Gly His His Leu Val Arg Phe Tyr
 305                 310                 315                 320
 Phe Leu Thr Arg Val Tyr Ser Glu Tyr Leu Glu Asp Val Leu Glu Glu
                 325                 330                 335    
 Leu Thr Tyr Gly Pro Ala Pro Asp Leu Val Ile Ile Asn Ser Cys Leu
             340                 345                 350        
 Trp Asp Leu Ser Arg Tyr Gly Arg Cys Ser Met Glu Ser Tyr Arg Glu
         355                 360                 365            
 Asn Leu Glu Arg Val Phe Val Arg Met Asp Gln Val Leu Pro Asp Ser
     370                 375                 380                
 Cys Leu Leu Val Trp Asn Met Ala Met Pro Leu Gly Glu Arg Ile Thr
 385                 390                 395                 400
 Gly Gly Phe Leu Leu Pro Glu Leu Gln Pro Leu Ala Gly Ser Leu Arg
                 405                 410                 415    
 Arg Asp Val Val Glu Gly Asn Phe Tyr Ser Ala Thr Leu Ala Gly Asp
             420                 425                 430        
 His Cys Phe Asp Val Leu Asp Leu His Phe His Phe Arg His Ala Val
         435                 440                 445            
 Gln His Arg His Arg Asp Gly Val His Trp Asp Gln His Ala His Arg
     450                 455                 460                
 His Leu Ser His Leu Leu Leu Thr His Val Ala Asp Ala Trp Gly Val
 465                 470                 475                 480
 Glu Leu Pro Lys Arg Gly Tyr Pro Pro Asp Pro Trp Ile Glu Asp Trp
                 485                 490                 495    
 Ala Glu Met Asn His Pro Phe Gln Gly Ser His Arg Gln Thr Pro Asp
             500                 505                 510        
 Phe Gly Glu His Leu Ala Leu Leu Pro Pro Pro Pro Ser Ser Leu Pro
         515                 520                 525            
 Pro Pro Met Pro Phe Pro Tyr Pro Leu Pro Gln Pro Ser Pro Pro Pro
     530                 535                 540                
 Leu Phe Pro Pro Leu Pro Gln Asp Thr Pro Phe Phe Pro Gly Gln Pro
 545                 550                 555                 560
 Phe Pro Pro His Glu Phe Phe Asn Tyr Asn Pro Val Glu Asp Phe Ser
                 565                 570                 575    
 Met Pro Pro His Leu Gly Cys Gly Pro Gly Val Asn Phe Val Pro Gly
             580                 585                 590        
 Pro Leu Pro Pro Pro Ile Pro Gly Pro Asn Pro His Gly Gln His Trp
         595                 600                 605            
 Gly Pro Val Val His Arg Gly Met Pro Arg Tyr Val Pro Asn Ser Pro
     610                 615                 620                
 Tyr His Val Arg Arg Met Gly Gly Pro Cys Arg Gln Arg Leu Arg His
 625                 630                 635                 640
 Ser Glu Arg Leu Ile His Thr Tyr Lys Leu Asp Arg Arg Pro Pro Ala
                 645                 650                 655    
 His Ser Gly Thr Trp Pro Gly
             660            



      <210> 471
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 471
 Met Glu Glu Arg Leu Lys Val Ile Pro Lys Phe Cys Phe Pro Asp Ser
   1               5                  10                  15    
 Lys Asp Trp Met Pro Thr Ser Glu Leu Lys Ser Glu Thr Phe Ser Phe
              20                  25                  30        
 Val Leu Thr Gly Glu Asp Gly Ser Arg Trp Phe Gly Tyr Cys Lys Lys
          35                  40                  45            
 Leu Leu Pro Val Gly Lys Gly Lys Arg Leu Pro Glu Val Tyr Cys Met
      50                  55                  60                
 Val Ser Arg Leu Gly Cys Phe Asn Leu Phe Ser Lys Ile Leu Asp Glu
  65                  70                  75                  80
 Val Glu Lys Arg Arg Glu Met Ser Pro Ala Leu Val Tyr Pro Phe Met
                  85                  90                  95    
 Arg Ser Val Met Glu Ala Pro Phe Pro Ala Pro Gly Arg Thr Ile Thr
             100                 105                 110        
 Val Lys Ser Tyr Leu Pro Gly Ala Gly Asp Glu Ser Ile Glu Leu Cys
         115                 120                 125            
 Arg Pro Leu Asp Ser Arg Leu Glu His Val Asp Phe Lys Cys Leu Phe
     130                 135                 140                
 Lys Cys Leu Ser Val Cys His Leu Ile Arg Val Cys Ala Ser Leu Leu
 145                 150                 155                 160
 Leu Glu Arg Arg Val Ile Phe Val Ala Asn Ser Leu Ser Thr Leu Ser
                 165                 170                 175    
 Lys Cys Gly His Ala Val Val Ala Thr Leu Tyr Pro Phe Thr Trp Gln
             180                 185                 190        
 His Thr Tyr Ile Pro Val Leu Pro Ala Ser Met Ile Asp Ile Val Cys
         195                 200                 205            
 Ser Pro Thr Pro Phe Leu Ile Gly Ile Leu Ser Cys Ser Leu Pro Gln
     210                 215                 220                
 Leu Gln Asp Leu Pro Ile Glu Glu Val Leu Ile Val Asp Leu Cys Ala
 225                 230                 235                 240
 Asp Lys Phe Leu Gln Glu Val Ser Asp Glu Asp Glu Ile Leu Pro Pro
                 245                 250                 255    
 Lys Leu Gln Ala Ala Leu Met Gln Ile Leu Glu Glu Arg Asn Glu Ile
             260                 265                 270        
 Leu Thr Gln Glu Gln Asn Phe Ser Gln Ala Asp Val Thr Leu Asn Ser
         275                 280                 285            
 Leu Val Ser Glu Ala Phe Val Arg Phe Phe Val Glu Leu Val Gly His
     290                 295                 300                
 Tyr Ser Leu Asn Met Thr Val Thr Glu Arg Gly Glu Arg Val Phe Gln
 305                 310                 315                 320
 Arg Glu Pro Phe Arg Lys Ser His Thr Ser Arg Ser Val Arg His Phe
                 325                 330                 335    
 Leu Asp Leu Phe Met Glu Thr Gln Met Phe Ala Gly Phe Ile Gln Asp
             340                 345                 350        
 Arg Glu Leu Arg Lys Ser Gly Val Lys Gly Leu Phe Glu Ile Arg Ala
         355                 360                 365            
 Ile Gln Tyr Leu Glu Thr Ile Pro Glu Ser Glu Pro Ser Gly Met Asn
     370                 375                 380                
 Arg Ile Leu Arg Ser Leu Gly Ser Lys Met Lys Phe Leu Gln Lys Lys
 385                 390                 395                 400





      <210> 472
      <211> 127
      <212> PRT
      <213> Homo sapiens


      <400> 472
 Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val
   1               5                  10                  15    
 Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe
              20                  25                  30        
 Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys
          35                  40                  45            
 Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser
      50                  55                  60                
 Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys
  65                  70                  75                  80
 Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile
                  85                  90                  95    
 Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln
             100                 105                 110        
 Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Glu Val Leu Trp
         115                 120                 125        



      <210> 473
      <211> 218
      <212> PRT
      <213> Homo sapiens


      <400> 473
 Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val
   1               5                  10                  15    
 Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe
              20                  25                  30        
 Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys
          35                  40                  45            
 Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser
      50                  55                  60                
 Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys
  65                  70                  75                  80
 Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile
                  85                  90                  95    
 Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln
             100                 105                 110        
 Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg
         115                 120                 125            
 Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe
     130                 135                 140                
 Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly
 145                 150                 155                 160
 Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His
                 165                 170                 175    
 Ser Arg Asn Lys Arg Leu Ser Ile Ser Ile Leu Gln Val Glu Thr Leu
             180                 185                 190        
 Leu Pro Leu Phe Gln Glu Asn Met Lys Arg Lys Cys Asp Tyr Asn His
         195                 200                 205            
 Asn Arg Asn Ile Leu Leu Ile Glu Gly Ile
     210                 215            



      <210> 474
      <211> 241
      <212> PRT
      <213> Homo sapiens


      <400> 474
 Met Ala Pro Asn Ile Tyr Leu Val Arg Gln Arg Ile Ser Arg Leu Gly
   1               5                  10                  15    
 Gln Arg Met Ser Gly Phe Gln Ile Asn Leu Asn Pro Leu Lys Glu Pro
              20                  25                  30        
 Leu Gly Phe Ile Lys Val Leu Glu Trp Ile Ala Ser Ile Phe Ala Phe
          35                  40                  45            
 Ala Thr Cys Gly Gly Phe Lys Gly Gln Thr Glu Ile Gln Val Asn Cys
      50                  55                  60                
 Pro Pro Ala Val Thr Glu Asn Gln Pro Pro Pro Gly Val Asn Ile Cys
  65                  70                  75                  80
 Asp Val Asn Trp Lys Asp Tyr Val Leu Ile Gly Asp Tyr Ser Ser Ser
                  85                  90                  95    
 Ala Gln Phe Tyr Val Thr Phe Ala Val Phe Val Phe Leu Tyr Cys Ile
             100                 105                 110        
 Ala Ala Leu Leu Leu Tyr Val Gly Tyr Thr Ser Leu Tyr Leu Asp Ser
         115                 120                 125            
 Arg Lys Leu Pro Met Ile Asp Phe Val Val Thr Leu Val Ala Thr Phe
     130                 135                 140                
 Leu Trp Leu Val Ser Thr Ser Ala Trp Ala Lys Ala Leu Thr Asp Ile
 145                 150                 155                 160
 Lys Ile Ala Thr Gly His Asn Ile Ile Asp Glu Leu Pro Pro Cys Lys
                 165                 170                 175    
 Lys Lys Ala Val Leu Cys Tyr Phe Gly Ser Val Thr Ser Met Gly Ser
             180                 185                 190        
 Leu Asn Val Ser Val Ile Phe Gly Phe Leu Asn Met Ile Leu Trp Gly
         195                 200                 205            
 Gly Asn Ala Trp Phe Val Tyr Lys Glu Thr Ser Leu His Ser Pro Ser
     210                 215                 220                
 Asn Thr Ser Ala Pro His Ser Gln Gly Gly Ile Pro Pro Pro Thr Gly
 225                 230                 235                 240
 Ile
    



      <210> 475
      <211> 421
      <212> PRT
      <213> Homo sapiens


      <400> 475
 Met Ala Pro Glu Glu Asn Ala Gly Thr Glu Leu Leu Leu Gln Ser Phe
   1               5                  10                  15    
 Glu Arg Arg Phe Leu Ala Ala Arg Thr Leu Arg Ser Phe Pro Trp Gln
              20                  25                  30        
 Ser Leu Glu Ala Lys Leu Arg Asp Ser Ser Asp Ser Glu Leu Leu Arg
          35                  40                  45            
 Asp Ile Leu His Lys Thr Val Lys His Pro Val Cys Val Lys His Pro
      50                  55                  60                
 Pro Ser Val Lys Tyr Ala Arg Cys Phe Leu Ser Glu Leu Ile Lys Lys
  65                  70                  75                  80
 Pro Ser Gly Gly Ser Val Thr Leu Ser Glu Ser Thr Ala Ile Ile Ser
                  85                  90                  95    
 Tyr Gly Thr Thr Gly Leu Val Thr Trp Asp Ala Ala Leu Tyr Leu Ala
             100                 105                 110        
 Glu Trp Ala Ile Glu Asn Pro Ala Val Phe Thr Asn Arg Thr Val Leu
         115                 120                 125            
 Glu Leu Gly Ser Gly Ala Gly Leu Thr Gly Leu Ala Ile Cys Lys Met
     130                 135                 140                
 Cys Arg Pro Arg Ala Tyr Ile Phe Ser Asp Cys His Ser Arg Val Leu
 145                 150                 155                 160
 Glu Gln Leu Arg Gly Asn Val Leu Leu Asn Gly Leu Ser Leu Glu Ala
                 165                 170                 175    
 Asp Ile Thr Ala Lys Leu Asp Ser Pro Arg Val Thr Val Ala Gln Leu
             180                 185                 190        
 Asp Trp Asp Val Ala Thr Val His Gln Leu Ser Ala Phe Gln Pro Asp
         195                 200                 205            
 Val Val Ile Ala Ala Asp Val Leu Tyr Cys Pro Glu Ala Ile Met Ser
     210                 215                 220                
 Leu Val Gly Val Leu Arg Arg Leu Ala Ala Cys Arg Glu Asp Gln Arg
 225                 230                 235                 240
 Ala Pro Glu Val Tyr Val Ala Phe Thr Val Arg Asn Pro Glu Thr Cys
                 245                 250                 255    
 Gln Leu Phe Thr Thr Glu Leu Ala Glu Pro Pro His Ala Pro Gly Pro
             260                 265                 270        
 Ala Trp Ser Leu Ser Cys Pro Cys Arg Thr Pro Val Glu Val Lys Glu
         275                 280                 285            
 Leu Gly Thr Gly Glu Lys Leu Gly Cys Pro Thr Leu Leu His His Ala
     290                 295                 300                
 Gly Asn Ser Gly Thr Gly Arg Thr Val Leu Glu Leu Gly Ser Gly Ala
 305                 310                 315                 320
 Gly Leu Thr Gly Leu Ala Ile Cys Lys Met Cys Arg Pro Arg Ala Tyr
                 325                 330                 335    
 Ile Phe Ser Asp Pro His Ser Arg Val Leu Glu Gln Leu Gln Gly Asn
             340                 345                 350        
 Val Phe Leu Asn Gly Leu Ser Leu Glu Ala Asp Ile Thr Ala Asn Leu
         355                 360                 365            
 Asp Ser Pro Arg Val Thr Val Ala Gln Leu Asp Trp Asp Val Ala Thr
     370                 375                 380                
 Val His Gln Leu Ser Ala Phe Gln Pro Asp Val Val Ile Ala Ala Gly
 385                 390                 395                 400
 Asn Ala Gln Pro Arg Ala Pro Cys Ala Gly Gly Val Leu Ala Ala Leu
                 405                 410                 415    
 Pro Ser Ser Trp Leu
             420    



      <210> 476
      <211> 804
      <212> PRT
      <213> Homo sapiens


      <400> 476
 Met Asp Leu Pro Val Asp Glu Trp Lys Ser Tyr Leu Leu Gln Lys Trp
   1               5                  10                  15    
 Ala Ser Leu Pro Thr Ser Val Gln Val Thr Ile Ser Thr Ala Glu Thr
              20                  25                  30        
 Leu Arg Asp Ile Phe Leu His Ser Ser Ser Leu Leu Gln Pro Glu Asp
          35                  40                  45            
 Glu Leu Phe Leu Lys Arg Leu Ser Lys Gly Tyr Leu Val Gly Lys Asp
      50                  55                  60                
 Ser Asp Ala Pro Leu Phe Tyr Arg Glu Glu Gly Asn Lys Lys Phe Gln
  65                  70                  75                  80
 Glu Lys Asp Tyr Thr Gly Ala Ala Val Leu Tyr Ser Lys Gly Val Ser
                  85                  90                  95    
 His Ser Arg Pro Asn Thr Glu Asp Met Ser Leu Cys His Ala Asn Arg
             100                 105                 110        
 Ser Ala Ala Leu Phe His Leu Gly Gln Tyr Glu Thr Cys Leu Lys Asp
         115                 120                 125            
 Ile Asn Ile Ala Gln Thr His Gly Tyr Pro Glu Arg Leu Gln Pro Lys
     130                 135                 140                
 Ile Met Leu Arg Lys Ala Glu Cys Leu Val Ala Leu Gly Arg Leu Gln
 145                 150                 155                 160
 Glu Ala Ser Gln Thr Ile Ser Asp Leu Glu Arg Asn Phe Thr Ala Thr
                 165                 170                 175    
 Pro Ala Leu Ala Asp Val Leu Pro Gln Thr Leu Gln Arg Asn Leu His
             180                 185                 190        
 Arg Leu Lys Met Lys Met Gln Glu Lys Asp Ser Leu Thr Glu Ser Phe
         195                 200                 205            
 Pro Ala Ala Leu Ala Lys Thr Leu Glu Asp Ala Ala Leu Arg Glu Glu
     210                 215                 220                
 Asn Glu Gln Leu Ser Asn Ala Ser Ser Ser Ile Gly Leu Cys Val Asp
 225                 230                 235                 240
 Pro Leu Lys Gly Arg Cys Leu Val Ala Thr Lys Asp Ile Leu Pro Gly
                 245                 250                 255    
 Glu Leu Leu Val Gln Glu Asp Ala Phe Val Ser Val Leu Asn Pro Gly
             260                 265                 270        
 Glu Leu Pro Pro Pro His His Gly Leu Asp Ser Lys Trp Asp Thr Arg
         275                 280                 285            
 Val Thr Asn Gly Asp Leu Tyr Cys His Arg Cys Leu Lys His Thr Leu
     290                 295                 300                
 Ala Thr Val Pro Cys Asp Gly Cys Ser Tyr Ala Lys Tyr Cys Ser Gln
 305                 310                 315                 320
 Glu Cys Leu Gln Gln Ala Trp Glu Leu Tyr His Arg Thr Glu Cys Pro
                 325                 330                 335    
 Leu Gly Gly Leu Leu Leu Thr Leu Gly Val Phe Cys His Ile Ala Leu
             340                 345                 350        
 Arg Leu Thr Leu Leu Val Gly Phe Glu Asp Val Arg Lys Ile Ile Thr
         355                 360                 365            
 Lys Leu Cys Asp Lys Ile Ser Asn Lys Asp Ile Cys Leu Arg Glu Ser
     370                 375                 380                
 Asn Asn Gln Val Lys Thr Leu Asn Tyr Gly Leu Gly Glu Ser Glu Lys
 385                 390                 395                 400
 Asn Gly Asn Ile Val Glu Thr Pro Ile Pro Gly Cys Asp Ile Asn Gly
                 405                 410                 415    
 Lys Tyr Glu Asn Asn Tyr Asn Ala Val Phe Asn Leu Leu Pro His Thr
             420                 425                 430        
 Glu Asn His Ser Pro Glu His Lys Phe Leu Cys Ala Leu Cys Val Ser
         435                 440                 445            
 Ala Leu Cys Arg Gln Leu Glu Ala Ala Ser Leu Gln Ala Ile Pro Thr
     450                 455                 460                
 Glu Arg Ile Val Asn Ser Ser Gln Leu Lys Ala Ala Val Thr Pro Glu
 465                 470                 475                 480
 Leu Cys Pro Asp Val Thr Ile Trp Gly Val Ala Met Leu Arg His Met
                 485                 490                 495    
 Leu Gln Leu Gln Cys Asn Ala Gln Ala Met Thr Thr Ile Gln His Thr
             500                 505                 510        
 Gly Pro Lys Gly Ser Ile Val Thr Asp Ser Arg Gln Val Arg Leu Ala
         515                 520                 525            
 Thr Gly Ile Phe Pro Val Ile Ser Leu Leu Asn His Ser Cys Ser Pro
     530                 535                 540                
 Asn Thr Ser Val Ser Phe Ile Ser Thr Val Ala Thr Ile Arg Ala Ser
 545                 550                 555                 560
 Gln Arg Ile Arg Lys Gly Gln Glu Ile Leu His Cys Tyr Gly Pro His
                 565                 570                 575    
 Lys Ser Arg Met Gly Val Ala Glu Arg Gln Gln Lys Leu Arg Ser Gln
             580                 585                 590        
 Tyr Phe Phe Asp Cys Ala Cys Pro Ala Cys Gln Thr Glu Ala His Arg
         595                 600                 605            
 Met Ala Ala Gly Pro Arg Trp Glu Ala Phe Cys Cys Asn Ser Cys Gly
     610                 615                 620                
 Ala Pro Met Gln Gly Asp Asp Val Leu Arg Cys Gly Ser Arg Ser Cys
 625                 630                 635                 640
 Ala Glu Ser Ala Val Ser Arg Asp His Leu Val Ser Arg Leu Gln Asp
                 645                 650                 655    
 Leu Gln Gln Gln Val Arg Val Ala Gln Lys Leu Leu Arg Asp Gly Glu
             660                 665                 670        
 Leu Glu Arg Ala Val Gln Arg Leu Ser Gly Cys Gln Arg Asp Ala Glu
         675                 680                 685            
 Ser Phe Leu Trp Ala Glu His Ala Val Val Gly Glu Ile Ala Asp Gly
     690                 695                 700                
 Leu Ala Arg Ala Cys Ala Ala Leu Gly Asp Trp Gln Lys Ser Ala Thr
 705                 710                 715                 720
 His Leu Gln Arg Ser Leu Cys Val Val Glu Val Arg His Gly Pro Ser
                 725                 730                 735    
 Ser Val Glu Met Gly His Glu Leu Phe Lys Leu Ala Gln Ile Phe Phe
             740                 745                 750        
 Asn Gly Phe Ala Val Pro Glu Ala Leu Ser Thr Ile Gln Lys Ala Glu
         755                 760                 765            
 Glu Val Leu Ser Leu His Cys Gly Pro Trp Asp Asp Glu Ile Gln Glu
     770                 775                 780                
 Leu Gln Lys Met Lys Ser Cys Leu Leu Asp Leu Pro Pro Thr Pro Val
 785                 790                 795                 800
 Gly Pro Ala Leu
                



      <210> 477
      <211> 324
      <212> PRT
      <213> Homo sapiens


      <400> 477
 Met Val Gln Gly Gln Leu Arg Val Leu Gly Gln Glu Gly Asn Leu Leu
   1               5                  10                  15    
 Leu His Arg Thr Ser Glu Asp Pro Glu Arg Gln Leu Val Leu Ala Gly
              20                  25                  30        
 Leu Phe Leu Ser Met Cys Leu Val Thr Val Leu Gly Asn Leu Ile Ile
          35                  40                  45            
 Ile Leu Asp Val Ser Pro Asp Ser His Leu Pro Thr Pro Met Tyr Phe
      50                  55                  60                
 Phe Leu Ser Asn Leu Ser Leu Pro Asp Ile Gly Phe Thr Ser Thr Thr
  65                  70                  75                  80
 Val Pro Lys Met Ile Val Asp Met Gln Thr His Ser Arg Val Ile Ser
                  85                  90                  95    
 Tyr Glu Gly Cys Leu Thr Gln Met Ser Phe Phe Val Leu Phe Ala Cys
             100                 105                 110        
 Met Asp Asp Met Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala
         115                 120                 125            
 Ile Cys His Pro Leu His Tyr Arg Ile Ile Met Asn Pro Arg Leu Cys
     130                 135                 140                
 Gly Phe Leu Ile Leu Leu Ser Phe Phe Ile Ser Leu Leu Asp Ser Gln
 145                 150                 155                 160
 Leu His Asn Leu Ile Met Leu Gln Leu Thr Cys Phe Lys Asp Val Asp
                 165                 170                 175    
 Ile Ser Asn Phe Phe Cys Asp Pro Ser Gln Leu Leu His Leu Arg Cys
             180                 185                 190        
 Ser Asp Thr Phe Ile Asn Glu Met Val Ile Tyr Phe Met Gly Ala Ile
         195                 200                 205            
 Phe Gly Cys Leu Pro Ile Ser Gly Ile Leu Phe Ser Tyr Tyr Lys Ile
     210                 215                 220                
 Val Ser Pro Ile Leu Arg Val Pro Thr Ser Asp Gly Lys Tyr Lys Ala
 225                 230                 235                 240
 Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Cys Leu Phe Tyr Gly
                 245                 250                 255    
 Thr Gly Leu Val Gly Tyr Leu Ser Ser Ala Val Leu Pro Ser Pro Arg
             260                 265                 270        
 Lys Ser Met Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu
         275                 280                 285            
 Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Gln Ser Ala Leu
     290                 295                 300                
 Cys Arg Leu His Gly Arg Ile Ile Lys Ser His His Leu His Pro Phe
 305                 310                 315                 320
 Cys Tyr Met Gly
                



      <210> 478
      <211> 367
      <212> PRT
      <213> Homo sapiens


      <400> 478
 Met Asn His Leu Gly His Ile Ala Gly Leu His Gln Asn Arg Asn Cys
   1               5                  10                  15    
 Ser Thr Gly Ala Val Gly Ala Gly Ala Asp Val Ile Ala Gln Cys Thr
              20                  25                  30        
 Val Leu Pro Ala Met Lys Leu Asp Phe Asp Ala Asn Leu Tyr Leu Cys
          35                  40                  45            
 Glu Glu Ala Phe Gly Leu Leu Pro Phe Asn Thr Phe Gly Arg Leu Ser
      50                  55                  60                
 Asp Thr Leu Leu Phe Tyr Ala Tyr Ile Phe Val Leu Ser Ile Thr Val
  65                  70                  75                  80
 Ile Val Ala Phe Val Val Ala Phe His Asn Leu Ser Asp Ser Thr Asn
                  85                  90                  95    
 Gln Gln Ser Val Gly Lys Met Glu Lys Gly Thr Val Asp Leu Lys Pro
             100                 105                 110        
 Glu Thr Ala Tyr Asn Leu Ile His Thr Ile Leu Phe Gly Phe Leu Ala
         115                 120                 125            
 Leu Ser Thr Met Arg Met Lys Tyr Leu Trp Thr Ser His Met Cys Val
     130                 135                 140                
 Phe Ala Ser Phe Gly Leu Cys Ser Pro Glu Ile Trp Glu Leu Leu Leu
 145                 150                 155                 160
 Lys Ser Val His Leu Tyr Asn Pro Lys Arg Ile Cys Ile Met Arg Tyr
                 165                 170                 175    
 Ser Val Pro Ile Leu Ile Leu Leu Tyr Leu Cys Tyr Lys Phe Trp Pro
             180                 185                 190        
 Gly Met Met Asp Glu Leu Ser Glu Leu Arg Glu Phe Tyr Asp Pro Asp
         195                 200                 205            
 Thr Val Glu Leu Met Asn Trp Ile Asn Ser Asn Thr Pro Arg Lys Ala
     210                 215                 220                
 Val Phe Ala Gly Ser Met Gln Leu Leu Ala Gly Val Lys Leu Cys Thr
 225                 230                 235                 240
 Gly Arg Thr Leu Thr Asn His Pro His Tyr Glu Asp Ser Ser Leu Arg
                 245                 250                 255    
 Glu Arg Thr Arg Ala Val Tyr Gln Ile Tyr Ala Lys Arg Ala Pro Glu
             260                 265                 270        
 Glu Val His Ala Leu Leu Arg Ser Phe Gly Thr Asp Tyr Val Ile Leu
         275                 280                 285            
 Glu Asp Ser Ile Cys Tyr Glu Arg Arg His Arg Arg Gly Cys Arg Leu
     290                 295                 300                
 Arg Asp Leu Leu Asp Ile Ala Asn Gly His Met Met Asp Gly Pro Gly
 305                 310                 315                 320
 Glu Asn Asp Pro Asp Leu Lys Pro Ala Asp His Pro Arg Phe Cys Glu
                 325                 330                 335    
 Glu Ile Lys Arg Asn Leu Pro Pro Tyr Val Ala Tyr Phe Thr Arg Val
             340                 345                 350        
 Phe Gln Asn Lys Thr Phe His Val Tyr Lys Leu Ser Arg Asn Lys
         355                 360                 365        



      <210> 479
      <211> 229
      <212> PRT
      <213> Homo sapiens


      <400> 479
 Met Ser Glu Lys Glu Asn Asn Phe Pro Pro Leu Pro Lys Phe Ile Pro
   1               5                  10                  15    
 Val Lys Pro Cys Phe Tyr Gln Asn Phe Ser Asp Glu Ile Pro Val Glu
              20                  25                  30        
 His Gln Val Leu Val Lys Arg Ile Tyr Arg Leu Trp Met Phe Tyr Cys
          35                  40                  45            
 Ala Thr Leu Gly Val Asn Leu Ile Ala Cys Leu Ala Trp Trp Ile Gly
      50                  55                  60                
 Gly Gly Ser Gly Thr Asn Phe Gly Leu Ala Phe Val Trp Leu Leu Leu
  65                  70                  75                  80
 Phe Thr Pro Cys Gly Tyr Val Cys Trp Phe Arg Pro Val Tyr Lys Ala
                  85                  90                  95    
 Phe Arg Ala Asp Ser Ser Phe Asn Phe Met Ala Phe Phe Phe Ile Phe
             100                 105                 110        
 Gly Ala Gln Phe Val Leu Thr Val Ile Gln Ala Ile Gly Phe Ser Gly
         115                 120                 125            
 Trp Gly Ala Cys Gly Trp Leu Ser Ala Ile Gly Phe Phe Gln Tyr Ser
     130                 135                 140                
 Pro Gly Ala Ala Val Val Met Leu Leu Pro Ala Ile Met Phe Ser Val
 145                 150                 155                 160
 Ser Ala Ala Met Met Ala Ile Ala Ile Met Lys Val His Arg Ile Tyr
                 165                 170                 175    
 Arg Gly Ala Gly Gly Ser Phe Gln Lys Ala Gln Thr Glu Trp Asn Thr
             180                 185                 190        
 Gly Thr Trp Arg Asn Pro Pro Ser Arg Glu Ala Gln Tyr Asn Asn Phe
         195                 200                 205            
 Leu Arg Gln Gln Pro Ala Arg Val Pro His Cys Ala Gln Leu Pro Gly
     210                 215                 220                
 Ser Gly Gln Trp Pro
 225                



      <210> 480
      <211> 792
      <212> PRT
      <213> Homo sapiens


      <400> 480
 Met Leu Gln Gln Gln Tyr Asp Pro Gln Ser Gln Ala Glu Asp Gln Ser
   1               5                  10                  15    
 Pro Asp Ser Gly Asp Leu Leu Gly Arg Lys Val Gly Val Ser Met Val
              20                  25                  30        
 Thr Ala Asp Leu Gly Leu Val Ser Met Ile Arg Gln Gly Ile Leu Ala
          35                  40                  45            
 Leu Gln Leu Leu Pro Ser Asn Ser Ser Ala Gly Ile Ile Val Ile Thr
      50                  55                  60                
 Asp Gly Val Thr Ser Val Pro Asp Val Ala Val Cys Glu Thr Leu Leu
  65                  70                  75                  80
 Asn Gln Leu Arg Ser Gly Thr Val Ala Cys Ser Phe Val Gln Val Gly
                  85                  90                  95    
 Gly Val Tyr Ser Tyr Asp Cys Ser Phe Gly His Val Pro Asn Val Glu
             100                 105                 110        
 Leu Met Lys Phe Ile Ala Met Ala Thr Phe Gly Ser Tyr Leu Ser Thr
         115                 120                 125            
 Cys Pro Glu Pro Glu Pro Gly Asn Leu Gly Leu Thr Val Tyr His Arg
     130                 135                 140                
 Ala Phe Leu Leu Tyr Ser Phe Leu Arg Ser Gly Glu Ala Leu Asn Pro
 145                 150                 155                 160
 Glu Tyr Tyr Cys Gly Ser Gln His Arg Leu Phe Asn Glu His Leu Val
                 165                 170                 175    
 Ser Ala Ser Ser Asn Pro Ala Leu Ala Leu Arg Arg Lys Lys His Thr
             180                 185                 190        
 Glu Lys Glu Val Pro Ala Asp Leu Val Ser Thr Val Ser Val Arg Leu
         195                 200                 205            
 Arg Glu Gly Tyr Ser Val Arg Glu Val Thr Leu Ala Lys Gly Gly Ser
     210                 215                 220                
 Gln Leu Glu Val Lys Leu Val Leu Leu Trp Lys His Asn Met Arg Ile
 225                 230                 235                 240
 Glu Tyr Val Ala Met Ala Pro Trp Pro Leu Glu Pro Glu Gly Pro Arg
                 245                 250                 255    
 Val Thr Arg Val Glu Val Thr Met Glu Gly Gly Tyr Asp Ile Leu His
             260                 265                 270        
 Asp Val Ser Cys Ala Leu Arg Gln Pro Ile Arg Ser Leu Tyr Arg Thr
         275                 280                 285            
 His Val Ile Arg Arg Phe Trp Asn Thr Leu Gln Ser Ile Asn Gln Thr
     290                 295                 300                
 Asp Gln Met Leu Ala His Leu Gln Ser Phe Ser Ser Val Pro Glu His
 305                 310                 315                 320
 Phe Thr Leu Pro Asp Ser Thr Lys Ser Gly Val Pro Leu Phe Tyr Ile
                 325                 330                 335    
 Pro Pro Gly Ser Thr Thr Pro Val Leu Ser Leu Gln Pro Ser Gly Ser
             340                 345                 350        
 Asp Ser Ser His Ala Gln Phe Ala Ala Tyr Trp Lys Pro Val Leu Ser
         355                 360                 365            
 Met Asp Ala Asn Ser Trp Gln Arg Trp Leu His Met His Arg Leu Val
     370                 375                 380                
 Leu Ile Leu Glu His Asp Thr Pro Ile Pro Lys His Leu His Thr Pro
 385                 390                 395                 400
 Gly Ser Asn Gly Arg Tyr Ser Thr Ile Gln Cys Arg Ile Ser His Ser
                 405                 410                 415    
 Ser Leu Thr Ser Leu Leu Arg Asp Trp Ser Ser Phe Val Leu Val Glu
             420                 425                 430        
 Gly Tyr Ser Tyr Val Lys Leu Leu Ser Ser Ala Pro Asp Gln Pro Pro
         435                 440                 445            
 Asn Ser Phe Tyr Met Val Arg Ile Ile Ser Lys Ala Pro Cys Met Val
     450                 455                 460                
 Leu Arg Leu Gly Phe Pro Ile Gly Thr Pro Ala Pro Ala Arg His Lys
 465                 470                 475                 480
 Ile Val Ser Gly Leu Arg Glu Glu Ile Leu Arg Leu Arg Phe Pro His
                 485                 490                 495    
 Arg Val Gln Ser Lys Glu Pro Thr Pro Lys Val Lys Arg Lys Gly Leu
             500                 505                 510        
 Gly Gly Ala Gly Gly Gly Ser Ser Pro Ser Lys Ser Pro Pro Val Leu
         515                 520                 525            
 Gly Pro Gln Gln Ala Leu Ser Asp Arg Pro Cys Leu Val Val Leu His
     530                 535                 540                
 Lys Pro Leu Asp Lys Leu Leu Ile Arg Leu Val Gln Arg Tyr Glu Lys
 545                 550                 555                 560
 Leu Pro Leu Asp Tyr Arg Ala Pro Phe Leu Leu Thr Leu Glu Pro Pro
                 565                 570                 575    
 Gly Pro Leu Pro Leu Val Ser Gly Arg Ser Ala Ser Ser Ser Leu Ala
             580                 585                 590        
 Ser Leu Ser Arg Tyr Leu Tyr His Gln Arg Trp Leu Trp Ser Val Pro
         595                 600                 605            
 Ser Gly Leu Ala Pro Ala Leu Pro Leu Ser Ala Ile Ala Gln Leu Leu
     610                 615                 620                
 Ser Ile Leu Thr Asp Gly Glu Gly Ile Ile Asn Met Val Leu Glu Leu
 625                 630                 635                 640
 Pro Ile Gln Asn Glu Pro Pro Gly Gln Ala Ala Ala Glu Glu Lys His
                 645                 650                 655    
 Thr Cys Val Val Gln Tyr Ile Leu Phe Pro Pro His Ser Thr Ser Thr
             660                 665                 670        
 Lys Asp Ser Phe Ser Thr Asp Asp Asp Asn Asp Val Glu Val Glu Ala
         675                 680                 685            
 Leu Glu Gly Asp Ser Glu Leu Asn Leu Val Thr Glu Val Trp Val Glu
     690                 695                 700                
 Pro Gln Tyr Gly Arg Val Gly Pro Gly Pro Gly Ile Trp Lys His Leu
 705                 710                 715                 720
 Gln Asp Leu Thr Tyr Ser Glu Ile Pro Gln Ala Leu His Pro Arg Asp
                 725                 730                 735    
 Ala Ala Cys Ile Gly Ser Met Leu Ser Phe Glu Tyr Leu Ile Gln Leu
             740                 745                 750        
 Cys Gln Ser Lys Glu Trp Gly Pro Leu Pro Pro Glu Pro Arg Val Ser
         755                 760                 765            
 Asp Gly Glu Trp Gly Arg Arg Pro Thr Gly Gly Ala Gly Glu Ile Gly
     770                 775                 780                
 Ser Gly Arg Arg His Leu Arg Pro
 785                 790        



      <210> 481
      <211> 983
      <212> PRT
      <213> Homo sapiens


      <400> 481
 Met Glu Met Lys Leu Pro Gly Gln Glu Gly Phe Glu Ala Ser Ser Ala
   1               5                  10                  15    
 Pro Arg Asn Ile Pro Ser Gly Glu Leu Asp Ser Asn Pro Asp Pro Gly
              20                  25                  30        
 Thr Gly Pro Ser Pro Asp Gly Pro Ser Asp Thr Glu Ser Lys Glu Leu
          35                  40                  45            
 Gly Val Pro Lys Asp Pro Leu Leu Phe Ile Gln Leu Asn Glu Leu Leu
      50                  55                  60                
 Gly Trp Pro Gln Ala Leu Glu Trp Arg Glu Thr Gly Ser Ser Ser Ala
  65                  70                  75                  80
 Ser Leu Leu Leu Asp Met Gly Glu Met Pro Ser Ile Thr Leu Ser Thr
                  85                  90                  95    
 His Leu His His Arg Trp Val Leu Phe Glu Glu Lys Leu Glu Val Ala
             100                 105                 110        
 Ala Gly Arg Trp Ser Ala Pro His Val Pro Thr Leu Ala Leu Pro Ser
         115                 120                 125            
 Leu Gln Lys Leu Arg Ser Leu Leu Ala Glu Gly Leu Val Leu Leu Asp
     130                 135                 140                
 Cys Pro Ala Gln Ser Leu Leu Glu Leu Val Glu Gln Val Thr Arg Val
 145                 150                 155                 160
 Glu Ser Leu Ser Pro Glu Leu Arg Gly Gln Leu Gln Ala Leu Leu Leu
                 165                 170                 175    
 Gln Arg Pro Gln His Tyr Asn Gln Thr Thr Gly Thr Arg Pro Cys Trp
             180                 185                 190        
 Gly Ser Thr His Pro Arg Lys Ala Ser Asp Asn Glu Glu Ala Pro Leu
         195                 200                 205            
 Arg Glu Gln Cys Gln Asn Pro Leu Arg Gln Lys Leu Pro Pro Gly Ala
     210                 215                 220                
 Glu Ala Gly Thr Val Leu Ala Gly Glu Leu Gly Phe Leu Ala Gln Pro
 225                 230                 235                 240
 Leu Gly Ala Phe Val Arg Leu Arg Asn Pro Val Val Leu Gly Ser Leu
                 245                 250                 255    
 Thr Glu Val Ser Leu Pro Ser Arg Phe Phe Cys Leu Leu Leu Gly Pro
             260                 265                 270        
 Cys Met Leu Gly Lys Gly Tyr His Glu Met Gly Arg Ala Ala Ala Val
         275                 280                 285            
 Leu Leu Ser Asp Pro Gln Phe Gln Trp Ser Val Arg Arg Ala Ser Asn
     290                 295                 300                
 Leu His Asp Leu Leu Ala Ala Leu Asp Ala Phe Leu Glu Glu Val Thr
 305                 310                 315                 320
 Val Leu Pro Pro Gly Arg Trp Asp Pro Thr Ala Arg Ile Pro Pro Pro
                 325                 330                 335    
 Lys Cys Leu Pro Ser Gln His Lys Arg Leu Pro Ser Gln Gln Arg Glu
             340                 345                 350        
 Ile Arg Gly Pro Ala Val Pro Arg Leu Thr Ser Ala Glu Asp Arg His
         355                 360                 365            
 Arg His Gly Pro His Ala His Ser Pro Glu Leu Gln Arg Thr Gly Arg
     370                 375                 380                
 Leu Phe Gly Gly Leu Ile Gln Asp Val Arg Arg Lys Val Pro Trp Tyr
 385                 390                 395                 400
 Pro Ser Asp Phe Leu Asp Ala Leu His Leu Gln Cys Phe Ser Ala Val
                 405                 410                 415    
 Leu Tyr Ile Tyr Leu Ala Thr Val Thr Asn Ala Ile Thr Phe Gly Gly
             420                 425                 430        
 Leu Leu Gly Asp Ala Thr Asp Gly Ala Gln Gly Val Leu Glu Ser Phe
         435                 440                 445            
 Leu Gly Thr Ala Val Ala Gly Ala Ala Phe Cys Leu Met Ala Gly Gln
     450                 455                 460                
 Pro Leu Thr Ile Leu Ser Ser Thr Gly Pro Val Leu Val Phe Glu Arg
 465                 470                 475                 480
 Leu Leu Phe Ser Phe Ser Arg Asp Tyr Ser Leu Asp Tyr Leu Pro Phe
                 485                 490                 495    
 Arg Leu Trp Val Gly Ile Trp Val Ala Thr Phe Cys Leu Val Leu Val
             500                 505                 510        
 Ala Thr Glu Ala Ser Val Leu Val Arg Tyr Phe Thr Arg Phe Thr Glu
         515                 520                 525            
 Glu Gly Phe Cys Ala Leu Ile Ser Leu Ile Phe Ile Tyr Asp Ala Val
     530                 535                 540                
 Gly Lys Met Leu Asn Leu Thr His Thr Tyr Pro Ile Gln Lys Pro Gly
 545                 550                 555                 560
 Ser Ser Ala Tyr Gly Cys Leu Cys Gln Tyr Pro Gly Pro Gly Gly Asn
                 565                 570                 575    
 Glu Ser Gln Trp Ile Arg Thr Arg Pro Lys Asp Arg Asp Asp Ile Val
             580                 585                 590        
 Ser Met Asp Leu Gly Leu Ile Asn Ala Ser Leu Leu Pro Pro Pro Glu
         595                 600                 605            
 Cys Thr Arg Gln Gly Gly His Pro Arg Gly Pro Gly Cys His Thr Val
     610                 615                 620                
 Pro Asp Ile Ala Phe Phe Ser Leu Leu Leu Phe Leu Thr Ser Phe Phe
 625                 630                 635                 640
 Phe Ala Met Ala Leu Lys Cys Val Lys Thr Ser Arg Phe Phe Pro Ser
                 645                 650                 655    
 Val Val Arg Lys Gly Leu Ser Asp Phe Ser Ser Val Leu Ala Ile Leu
             660                 665                 670        
 Leu Gly Cys Gly Leu Asp Ala Phe Leu Gly Leu Ala Thr Pro Lys Leu
         675                 680                 685            
 Met Val Pro Arg Glu Phe Lys Pro Thr Leu Pro Gly Arg Gly Trp Leu
     690                 695                 700                
 Val Ser Pro Phe Gly Ala Asn Pro Trp Trp Trp Ser Val Ala Ala Ala
 705                 710                 715                 720
 Leu Pro Ala Leu Leu Leu Ser Ile Leu Ile Phe Met Asp Gln Gln Ile
                 725                 730                 735    
 Thr Ala Val Ile Leu Asn Arg Met Glu Tyr Arg Leu Gln Lys Gly Ala
             740                 745                 750        
 Gly Phe His Leu Asp Leu Phe Cys Val Ala Val Leu Met Leu Leu Thr
         755                 760                 765            
 Ser Ala Leu Gly Leu Pro Trp Tyr Val Ser Ala Thr Val Ile Ser Leu
     770                 775                 780                
 Ala His Met Asp Ser Leu Arg Arg Glu Ser Arg Ala Cys Ala Pro Gly
 785                 790                 795                 800
 Glu Arg Pro Asn Phe Leu Gly Ile Arg Glu Gln Arg Leu Thr Gly Leu
                 805                 810                 815    
 Val Val Phe Ile Leu Thr Gly Ala Ser Ile Phe Leu Ala Pro Val Leu
             820                 825                 830        
 Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Ile Phe Leu Tyr Met Gly
         835                 840                 845            
 Val Ala Ala Leu Ser Ser Ile Gln Phe Thr Asn Arg Val Lys Leu Leu
     850                 855                 860                
 Leu Met Pro Ala Lys His Gln Pro Asp Leu Leu Leu Leu Arg His Val
 865                 870                 875                 880
 Pro Leu Thr Arg Val His Leu Phe Thr Ala Ile Gln Leu Ala Cys Leu
                 885                 890                 895    
 Gly Leu Leu Trp Ile Ile Lys Ser Thr Pro Ala Ala Ile Ile Phe Pro
             900                 905                 910        
 Leu Met Leu Leu Gly Leu Val Gly Val Arg Lys Ala Leu Glu Arg Val
         915                 920                 925            
 Phe Ser Pro Gln Glu Leu Leu Trp Leu Asp Glu Leu Met Pro Glu Glu
     930                 935                 940                
 Glu Arg Ser Ile Pro Glu Lys Gly Leu Glu Pro Glu His Ser Phe Ser
 945                 950                 955                 960
 Gly Ser Asp Ser Glu Asp Ser Glu Leu Met Tyr Gln Pro Lys Ala Pro
                 965                 970                 975    
 Glu Ile Asn Ile Ser Val Asn
             980            



      <210> 482
      <211> 622
      <212> PRT
      <213> Homo sapiens


      <400> 482
 Met Asp Glu Leu Leu Leu His Thr Glu Pro Gln Phe Ser Cys Leu Gln
   1               5                  10                  15    
 Asn Gly Ala Thr Val Pro Phe Leu Leu Pro Ser Leu Leu Asn Val Thr
              20                  25                  30        
 Gln Leu Arg Leu Pro Phe Gly Ser Ser Ser Val Val Phe Ala His Phe
          35                  40                  45            
 Phe Leu Glu Ile Glu Gly Phe Glu Pro Asn Pro Thr Val Ala Lys Thr
      50                  55                  60                
 Ser Pro Pro Val Phe Ser Lys Pro Met Asp Ser Asn Ile Arg Gln Cys
  65                  70                  75                  80
 Ile Ser Gly Asn Cys Asp Asp Met Asp Ser Pro Gln Ser Pro Gln Asp
                  85                  90                  95    
 Asp Val Thr Glu Thr Pro Ser Asn Pro Asn Ser Pro Ser Ala Gln Leu
             100                 105                 110        
 Ala Lys Glu Glu Gln Arg Arg Lys Lys Arg Arg Leu Lys Lys Arg Ile
         115                 120                 125            
 Phe Ala Ala Val Ser Glu Gly Cys Val Glu Glu Leu Val Glu Leu Leu
     130                 135                 140                
 Val Glu Leu Gln Glu Leu Cys Arg Arg Arg His Asp Glu Asp Val Pro
 145                 150                 155                 160
 Asp Phe Leu Met His Lys Leu Thr Ala Ser Asp Thr Gly Lys Thr Cys
                 165                 170                 175    
 Leu Met Lys Ala Leu Leu Asn Ile Asn Pro Asn Thr Lys Glu Ile Val
             180                 185                 190        
 Arg Ile Leu Leu Ala Phe Ala Glu Glu Asn Asp Ile Leu Gly Arg Phe
         195                 200                 205            
 Ile Asn Ala Glu Tyr Thr Glu Glu Ala Tyr Glu Gly Gln Thr Ala Leu
     210                 215                 220                
 Asn Ile Ala Ile Glu Arg Arg Gln Gly Asp Ile Ala Ala Leu Leu Ile
 225                 230                 235                 240
 Ala Ala Gly Ala Asp Val Asn Ala His Ala Lys Gly Ala Phe Phe Asn
                 245                 250                 255    
 Pro Lys Tyr Gln His Glu Gly Phe Tyr Phe Gly Glu Thr Pro Leu Ala
             260                 265                 270        
 Leu Ala Ala Cys Thr Asn Gln Pro Glu Ile Val Gln Leu Leu Met Glu
         275                 280                 285            
 His Glu Gln Thr Asp Ile Thr Ser Arg Asp Ser Arg Gly Asn Asn Ile
     290                 295                 300                
 Leu His Ala Leu Val Thr Val Ala Glu Asp Phe Lys Thr Gln Asn Asp
 305                 310                 315                 320
 Phe Val Lys Arg Met Tyr Asp Met Ile Leu Leu Arg Ser Gly Asn Trp
                 325                 330                 335    
 Glu Leu Glu Thr Thr Arg Asn Asn Asp Gly Leu Thr Pro Leu Gln Leu
             340                 345                 350        
 Ala Ala Lys Met Gly Lys Ala Glu Ile Leu Lys Tyr Ile Leu Ser Arg
         355                 360                 365            
 Glu Ile Lys Glu Lys Arg Leu Arg Ser Leu Ser Arg Lys Phe Thr Asp
     370                 375                 380                
 Trp Ala Tyr Gly Pro Val Ser Ser Ser Leu Tyr Asp Leu Thr Asn Val
 385                 390                 395                 400
 Asp Thr Thr Thr Asp Asn Ser Val Leu Glu Ile Thr Val Tyr Asn Thr
                 405                 410                 415    
 Asn Ile Asp Asn Arg His Glu Met Leu Thr Leu Glu Pro Leu His Thr
             420                 425                 430        
 Leu Leu His Met Lys Trp Lys Lys Phe Ala Lys His Met Phe Leu Leu
         435                 440                 445            
 Ser Phe Cys Phe Tyr Phe Phe Tyr Asn Ile Thr Leu Thr Leu Val Ser
     450                 455                 460                
 Tyr Tyr Arg Pro Arg Glu Glu Glu Ala Ile Pro His Pro Leu Ala Leu
 465                 470                 475                 480
 Thr His Lys Met Gly Trp Leu Gln Leu Leu Gly Arg Met Phe Val Leu
                 485                 490                 495    
 Ile Trp Ala Met Cys Ile Ser Val Lys Glu Gly Ile Ala Ile Phe Leu
             500                 505                 510        
 Leu Arg Pro Ser Asp Leu Gln Ser Ile Leu Ser Asp Ala Trp Phe His
         515                 520                 525            
 Phe Val Phe Phe Ile Gln Ala Val Leu Val Ile Leu Ser Val Phe Leu
     530                 535                 540                
 Tyr Leu Phe Ala Tyr Lys Glu Tyr Leu Ala Cys Leu Val Leu Ala Met
 545                 550                 555                 560
 Ala Leu Gly Trp Ala Asn Met Leu Tyr Tyr Thr Arg Gly Phe Gln Ser
                 565                 570                 575    
 Met Gly Met Tyr Ser Val Met Ile Gln Lys Gly Gln Phe Pro Ala Thr
             580                 585                 590        
 Asn Ile Met Leu Leu Asp Ile Glu Leu Gly Arg Asn Met Gln Ile His
         595                 600                 605            
 Ile Ala Leu Glu Phe Leu Pro Tyr Gly Tyr Asp Arg Asp Lys
     610                 615                 620        



      <210> 483
      <211> 219
      <212> PRT
      <213> Homo sapiens


      <400> 483
 Met Gly Ala Pro His Trp Trp Asp Gln Leu Gln Ala Gly Ser Ser Glu
   1               5                  10                  15    
 Val Asp Trp Cys Glu Asp Asn Tyr Thr Ile Val Pro Ala Ile Ala Glu
              20                  25                  30        
 Phe Tyr Asn Thr Ile Ser Asn Val Leu Phe Phe Ile Leu Pro Pro Ile
          35                  40                  45            
 Cys Met Cys Leu Phe Arg Gln Arg Tyr Leu Pro Lys Ile Phe Arg Asn
      50                  55                  60                
 Asp Gln Gly Arg Phe Lys Val Val Val Cys Val Leu Ser Ala Val Met
  65                  70                  75                  80
 Thr Cys Leu Ala Phe Val Lys Pro Ala Ile Asn Asn Ile Ser Leu Met
                  85                  90                  95    
 Thr Leu Gly Val Pro Cys Ala Ala Leu Leu Ile Thr Glu Leu Lys Arg
             100                 105                 110        
 Cys Asp Asn Met Arg Val Phe Lys Leu Gly Leu Phe Ser Gly Leu Trp
         115                 120                 125            
 Trp Thr Leu Ala Leu Phe Cys Trp Ile Ser Asp Arg Ala Phe Cys Glu
     130                 135                 140                
 Leu Leu Ser Ser Phe Asn Phe Pro Tyr Leu His Cys Met Trp His Ile
 145                 150                 155                 160
 Leu Ile Cys Leu Ala Ala Tyr Leu Gly Cys Val Cys Phe Ala Tyr Phe
                 165                 170                 175    
 Asp Ala Ala Ser Glu Ile Pro Glu Gln Gly Pro Val Ile Lys Phe Trp
             180                 185                 190        
 Pro Asn Glu Lys Trp Ala Phe Ile Gly Val Pro Tyr Val Ser Leu Leu
         195                 200                 205            
 Cys Ala Asn Lys Lys Ser Ser Val Lys Ile Thr
     210                 215                



      <210> 484
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 484
 Met Val Thr Pro Ala Gly Cys Leu Gly Gly Arg Asn Gln Gly Pro Arg
   1               5                  10                  15    
 Glu Ile Pro Ala Thr Ala Phe Pro Arg Ser Ser Arg Ala Gly Gln Thr
              20                  25                  30        
 Gly Gln Ala Val Ser Gly Ala Gln Val Ser Ser Trp Arg Glu Arg Gln
          35                  40                  45            
 Pro Cys Gly Gly Ser Arg Gly Pro Leu His Ile Leu Gly Thr Asp Gly
      50                  55                  60                
 Asn Val Asp Thr Thr Gly Lys Leu Gly Leu Val Pro Thr Pro Pro Arg
  65                  70                  75                  80
 Ile Gln Lys Glu Thr Lys Gln Gly Ala Leu Cys Gly Met Lys Pro Pro
                  85                  90                  95    
 Phe Leu Pro Glu Ala Leu Leu Thr Val Trp Trp Leu Pro Phe Val Ala
             100                 105                 110        
 Val Ser Leu Cys Leu Phe
         115            



      <210> 485
      <211> 787
      <212> PRT
      <213> Homo sapiens


      <400> 485
 Met Lys Asn Leu Glu Phe Gln Thr Glu Tyr Leu Leu Cys Asp Cys Asn
   1               5                  10                  15    
 Ile Leu Trp Met His Arg Trp Val Lys Glu Lys Asn Ile Thr Val Arg
              20                  25                  30        
 Asp Thr Arg Cys Val Tyr Pro Lys Ser Leu Gln Ala Gln Pro Val Thr
          35                  40                  45            
 Gly Val Lys Gln Glu Leu Leu Thr Cys Asp Pro Pro Leu Glu Leu Pro
      50                  55                  60                
 Ser Phe Tyr Met Thr Pro Ser His Arg Gln Val Val Phe Glu Gly Asp
  65                  70                  75                  80
 Ser Leu Pro Phe Gln Cys Met Ala Ser Tyr Ile Asp Gln Asp Met Gln
                  85                  90                  95    
 Val Leu Trp Tyr Gln Asp Gly Arg Ile Val Glu Thr Asp Glu Ser Gln
             100                 105                 110        
 Gly Ile Phe Val Glu Lys Asn Met Ile His Asn Cys Ser Leu Ile Ala
         115                 120                 125            
 Ser Ala Leu Thr Ile Ser Asn Ile Gln Ala Gly Ser Thr Gly Asn Trp
     130                 135                 140                
 Gly Cys His Val Gln Thr Lys Arg Gly Asn Asn Thr Arg Thr Val Asp
 145                 150                 155                 160
 Ile Val Val Leu Glu Ser Ser Ala Gln Tyr Cys Pro Pro Glu Arg Val
                 165                 170                 175    
 Val Asn Asn Lys Gly Asp Phe Arg Trp Pro Arg Thr Leu Ala Gly Ile
             180                 185                 190        
 Thr Ala Tyr Leu Gln Cys Thr Arg Asn Thr His Gly Ser Gly Ile Tyr
         195                 200                 205            
 Pro Gly Asn Pro Gln Asp Glu Arg Lys Ala Trp Arg Arg Cys Asp Arg
     210                 215                 220                
 Gly Gly Phe Trp Ala Asp Asp Asp Tyr Ser Arg Cys Gln Tyr Ala Asn
 225                 230                 235                 240
 Asp Val Thr Arg Val Leu Tyr Met Phe Asn Gln Met Pro Leu Asn Leu
                 245                 250                 255    
 Thr Asn Ala Val Ala Thr Ala Arg Gln Leu Leu Ala Tyr Thr Val Glu
             260                 265                 270        
 Ala Ala Asn Phe Ser Asp Lys Met Asp Val Ile Phe Val Ala Glu Met
         275                 280                 285            
 Ile Glu Lys Phe Gly Arg Phe Thr Lys Glu Glu Lys Ser Lys Glu Leu
     290                 295                 300                
 Gly Asp Val Met Val Asp Ile Ala Ser Asn Ile Met Leu Ala Asp Glu
 305                 310                 315                 320
 Arg Val Leu Trp Leu Ala Gln Arg Glu Ala Lys Ala Cys Ser Arg Ile
                 325                 330                 335    
 Val Gln Cys Leu Gln Arg Ile Ala Thr Tyr Arg Leu Ala Gly Gly Ala
             340                 345                 350        
 His Val Tyr Ser Thr Tyr Ser Pro Asn Ile Ala Leu Glu Ala Tyr Val
         355                 360                 365            
 Ile Lys Ser Thr Gly Phe Thr Gly Met Thr Cys Thr Val Phe Gln Lys
     370                 375                 380                
 Val Ala Ala Ser Asp Arg Thr Gly Leu Ser Asp Tyr Gly Arg Arg Asp
 385                 390                 395                 400
 Pro Glu Gly Asn Leu Asp Lys Gln Leu Ser Phe Lys Cys Asn Val Ser
                 405                 410                 415    
 Asn Thr Phe Ser Ser Leu Ala Leu Lys Asn Thr Ile Val Glu Ala Ser
             420                 425                 430        
 Ile Gln Leu Pro Pro Ser Leu Phe Ser Pro Lys Gln Lys Arg Glu Leu
         435                 440                 445            
 Arg Pro Thr Asp Asp Ser Leu Tyr Lys Leu Gln Leu Ile Ala Phe Arg
     450                 455                 460                
 Asn Gly Lys Leu Phe Pro Ala Thr Gly Asn Ser Thr Asn Leu Ala Asp
 465                 470                 475                 480
 Asp Gly Lys Arg Arg Thr Val Val Thr Pro Val Ile Leu Thr Lys Ile
                 485                 490                 495    
 Asp Gly Val Asn Val Asp Thr His His Ile Pro Val Asn Val Thr Leu
             500                 505                 510        
 Arg Arg Ile Ala His Gly Ala Asp Ala Val Ala Ala Arg Trp Asp Phe
         515                 520                 525            
 Asp Leu Leu Asn Gly Gln Gly Gly Trp Lys Ser Asp Gly Cys His Ile
     530                 535                 540                
 Leu Tyr Ser Asp Glu Asn Ile Thr Thr Ile Gln Cys Tyr Ser Leu Ser
 545                 550                 555                 560
 Asn Tyr Ala Val Leu Met Asp Leu Thr Gly Ser Glu Leu Tyr Thr Gln
                 565                 570                 575    
 Ala Ala Ser Leu Leu His Pro Val Val Tyr Thr Thr Ala Ile Ile Leu
             580                 585                 590        
 Leu Leu Cys Leu Leu Ala Val Ile Val Ser Tyr Ile Tyr His His Ser
         595                 600                 605            
 Leu Ile Arg Ile Ser Leu Lys Ser Trp His Met Leu Val Asn Leu Cys
     610                 615                 620                
 Phe His Ile Phe Leu Thr Cys Val Val Phe Val Gly Gly Ile Thr Gln
 625                 630                 635                 640
 Thr Arg Asn Ala Ser Ile Cys Gln Ala Val Gly Ile Ile Leu His Tyr
                 645                 650                 655    
 Ser Thr Leu Ala Thr Val Leu Trp Val Gly Val Thr Ala Arg Asn Ile
             660                 665                 670        
 Tyr Lys Gln Val Thr Lys Lys Ala Lys Arg Cys Gln Asp Pro Asp Glu
         675                 680                 685            
 Pro Pro Pro Pro Pro Arg Pro Met Leu Arg Phe Tyr Leu Ile Gly Gly
     690                 695                 700                
 Gly Ile Pro Ile Ile Val Cys Gly Ile Thr Ala Ala Ala Asn Ile Lys
 705                 710                 715                 720
 Asn Tyr Gly Ser Arg Pro Asn Ala Pro Tyr Cys Trp Met Ala Trp Glu
                 725                 730                 735    
 Pro Ser Leu Gly Gly Phe Tyr Gly Pro Ala Ser Phe Ile Thr Phe Val
             740                 745                 750        
 Asn Cys Met Tyr Phe Leu Ser Ile Phe Ile Gln Leu Lys Arg His Pro
         755                 760                 765            
 Glu Arg Lys Tyr Glu Leu Lys Glu Pro Thr Glu Arg Ala Thr Glu Ile
     770                 775                 780                
 Gly Ser Gln
 785        



      <210> 486
      <211> 346
      <212> PRT
      <213> Homo sapiens


      <400> 486
 Met Tyr Asn Gly Ser Cys Cys Arg Ile Glu Gly Asp Thr Ile Ser Gln
   1               5                  10                  15    
 Val Met Pro Pro Leu Leu Ile Val Ala Phe Val Leu Gly Ala Leu Gly
              20                  25                  30        
 Asn Gly Val Ala Leu Cys Gly Phe Cys Phe His Met Lys Thr Trp Lys
          35                  40                  45            
 Pro Ser Thr Val Tyr Leu Phe Asn Leu Ala Val Ala Asp Phe Leu Leu
      50                  55                  60                
 Met Ile Cys Leu Pro Phe Arg Thr Asp Tyr Tyr Leu Arg Arg Arg His
  65                  70                  75                  80
 Trp Ala Phe Gly Asp Ile Pro Cys Arg Val Gly Leu Phe Thr Leu Ala
                  85                  90                  95    
 Met Asn Arg Ala Gly Ser Ile Val Phe Leu Thr Val Val Ala Ala Asp
             100                 105                 110        
 Arg Tyr Phe Lys Val Val His Pro His His Ala Val Asn Thr Ile Ser
         115                 120                 125            
 Thr Arg Val Ala Ala Gly Ile Val Cys Thr Leu Trp Ala Leu Val Ile
     130                 135                 140                
 Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln Glu
 145                 150                 155                 160
 Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly Trp
                 165                 170                 175    
 His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile Ile
             180                 185                 190        
 Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln Gln
         195                 200                 205            
 Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met Val
     210                 215                 220                
 Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala Arg
 225                 230                 235                 240
 Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser Val
                 245                 250                 255    
 His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser Met
             260                 265                 270        
 Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys Phe
         275                 280                 285            
 Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly His
     290                 295                 300                
 Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly Arg
 305                 310                 315                 320
 Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp Gly
                 325                 330                 335    
 Gln Trp Asp Pro His Ile Val Glu Trp His
             340                 345    



      <210> 487
      <211> 865
      <212> PRT
      <213> Homo sapiens


      <400> 487
 Met Val Lys Leu Ser Ile Val Leu Thr Pro Gln Phe Leu Ser His Asp
   1               5                  10                  15    
 Gln Gly Gln Leu Thr Lys Glu Leu Gln Gln His Val Lys Ser Val Thr
              20                  25                  30        
 Cys Pro Cys Glu Tyr Leu Arg Lys Val Ile Asn Thr Leu Ala Asp His
          35                  40                  45            
 His His Arg Gly Thr Asp Phe Gly Gly Ser Pro Trp Leu His Val Ile
      50                  55                  60                
 Ile Ala Phe Pro Thr Ser Tyr Lys Val Val Ile Thr Leu Trp Ile Val
  65                  70                  75                  80
 Tyr Leu Trp Val Ser Leu Leu Lys Thr Ile Phe Trp Ser Arg Asn Gly
                  85                  90                  95    
 His Asp Gly Ser Thr Asp Val Gln Gln Arg Ala Trp Arg Ser Asn Arg
             100                 105                 110        
 Arg Arg Gln Glu Gly Leu Arg Ser Ile Cys Met His Thr Lys Lys Arg
         115                 120                 125            
 Val Ser Ser Phe Arg Gly Asn Lys Ile Gly Leu Lys Asp Val Ile Thr
     130                 135                 140                
 Leu Arg Arg His Val Glu Thr Lys Val Arg Ala Lys Ile Arg Lys Arg
 145                 150                 155                 160
 Lys Val Thr Thr Lys Ile Asn His His Asp Lys Ile Asn Gly Lys Arg
                 165                 170                 175    
 Lys Thr Ala Arg Lys Gln Lys Met Phe Gln Arg Ala Gln Glu Leu Arg
             180                 185                 190        
 Arg Arg Ala Glu Asp Tyr His Lys Cys Lys Ile Pro Pro Ser Ala Arg
         195                 200                 205            
 Lys Ala Leu Cys Asn Trp Val Arg Met Ala Ala Ala Glu His Arg His
     210                 215                 220                
 Ser Ser Gly Leu Pro Tyr Trp Pro Tyr Leu Thr Ala Glu Thr Leu Lys
 225                 230                 235                 240
 Asn Arg Met Gly His Gln Pro Pro Pro Pro Thr Gln Gln His Ser Ile
                 245                 250                 255    
 Thr Asp Asn Ser Leu Ser Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr
             260                 265                 270        
 Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Pro Glu Cys
         275                 280                 285            
 Val Leu Thr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
     290                 295                 300                
 Pro Glu Cys Val Leu Thr Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu
 305                 310                 315                 320
 Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro Ser Ala Asp
                 325                 330                 335    
 Asp Asn Leu Lys Thr Pro Pro Glu Cys Leu Leu Thr Pro Leu Pro Pro
             340                 345                 350        
 Ser Ala Leu Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr
         355                 360                 365            
 Arg Ala Glu Cys Leu Leu His Pro Leu Pro Pro Ser Ala Asp Asp Asn
     370                 375                 380                
 Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala
 385                 390                 395                 400
 Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg
                 405                 410                 415    
 Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu
             420                 425                 430        
 Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp
         435                 440                 445            
 Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser
     450                 455                 460                
 Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu
 465                 470                 475                 480
 Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala
                 485                 490                 495    
 Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys
             500                 505                 510        
 Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro
         515                 520                 525            
 Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg Leu Arg Gly Pro
     530                 535                 540                
 Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln
 545                 550                 555                 560
 Leu Thr Pro Leu Pro Pro Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile
                 565                 570                 575    
 Lys Thr Pro Ala Phe His Pro Gln Arg Met Ile Ile Ser Arg His Leu
             580                 585                 590        
 Pro Ser Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro Gln Gln
         595                 600                 605            
 Met Ile Ile Ser Arg Tyr Leu Leu Ser Val Cys Gly Phe Arg Phe His
     610                 615                 620                
 His Gln Pro Met Ile Ile Ser Arg His Leu Pro Ser Val Ser Ser Leu
 625                 630                 635                 640
 Pro Phe His Pro Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg His
                 645                 650                 655    
 Leu Pro Ser Val Cys Gly Gly Arg Phe His Pro Gln Arg Met Ile Ile
             660                 665                 670        
 Ser Arg His Leu Pro Ser Ile Ser Ser Leu Pro Phe His Pro Gln Leu
         675                 680                 685            
 His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro Ser Val Cys Gly
     690                 695                 700                
 Gly Arg Phe His Pro Gln Arg Met Ile Ile Ser Arg His Leu Pro Ser
 705                 710                 715                 720
 Val Ser Ser Leu Pro Phe His Pro Gln Leu His Pro Gln Gln Met Ile
                 725                 730                 735    
 Ile Ser Arg His Leu Pro Ser Val Cys Gly Gly Arg Phe His Pro Gln
             740                 745                 750        
 Arg Met Ile Ile Ser Arg His Leu Pro Ser Val Ser Ser Leu Pro Phe
         755                 760                 765            
 His Thr Gln Leu His Pro Gln Gln Met Ile Ile Ser Arg His Leu Pro
     770                 775                 780                
 Ser Val Cys Gly Glu Arg Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp
 785                 790                 795                 800
 Asp Asn Leu Lys Thr Pro Ser Glu Arg Gln Leu Thr Pro Leu Pro Pro
                 805                 810                 815    
 Ser Ala Pro Pro Ser Ala Asp Asp Asn Ile Lys Thr Pro Ala Glu Arg
             820                 825                 830        
 Leu Arg Gly Pro Leu Pro Pro Ser Ala Asp Asp Asn Leu Lys Thr Pro
         835                 840                 845            
 Tyr Arg Ala Ser Ala His Ser Pro Ser Thr Leu Ser Ser Thr Leu Ser
     850                 855                 860                
 Arg
 865



      <210> 488
      <211> 160
      <212> PRT
      <213> Homo sapiens


      <400> 488
 Met Asn Trp Pro Pro Thr His Trp Ala Val Ala Lys Arg Gly Cys Ser
   1               5                  10                  15    
 Gly Cys Asn Cys Pro Ser Gly Leu Ser Ser Gln Gly Arg Glu Glu Asn
              20                  25                  30        
 Ser Pro Asp Pro Gln Gly Ser Gly Ile Gln Thr Ala Gly Gly Pro Ala
          35                  40                  45            
 Pro Ser Val Phe Leu Leu Pro Leu Pro Gln Val Asn Leu Leu Ile Pro
      50                  55                  60                
 Val Ala Tyr Leu Val Phe Trp Ala Phe Leu Leu Val Phe Ser Phe Ile
  65                  70                  75                  80
 Ser Glu Pro Met Val Cys Gly Val Gly Val Ile Ile Ile Leu Thr Gly
                  85                  90                  95    
 Val Pro Ile Phe Phe Leu Gly Val Phe Trp Arg Ser Lys Pro Lys Cys
             100                 105                 110        
 Val His Arg Leu Thr Gly Ser Met Thr His Trp Gly Gln Glu Leu Cys
         115                 120                 125            
 Phe Val Val Tyr Pro Gln Asp Ala Pro Glu Glu Glu Glu Asn Gly Pro
     130                 135                 140                
 Cys Pro Pro Ser Leu Leu Pro Ala Thr Asp Lys Pro Ser Lys Pro Gln
 145                 150                 155                 160





      <210> 489
      <211> 449
      <212> PRT
      <213> Homo sapiens


      <400> 489
 Met Ala Ala Leu Ala Pro Val Gly Ser Pro Ala Ser Arg Gly Pro Arg
   1               5                  10                  15    
 Leu Ala Ala Gly Leu Arg Leu Leu Pro Met Leu Gly Leu Leu Gln Leu
              20                  25                  30        
 Leu Ala Glu Pro Gly Leu Gly Arg Val His His Leu Ala Leu Lys Asp
          35                  40                  45            
 Asp Val Arg His Lys Val His Leu Asn Thr Phe Gly Phe Phe Lys Asp
      50                  55                  60                
 Gly Tyr Met Val Val Asn Val Ser Ser Leu Ser Leu Asn Glu Pro Glu
  65                  70                  75                  80
 Asp Lys Asp Val Thr Ile Gly Phe Ser Leu Asp Arg Thr Lys Asn Asp
                  85                  90                  95    
 Gly Phe Phe Phe Tyr Leu Asp Glu Asp Val Asn Tyr Cys Ile Leu Lys
             100                 105                 110        
 Lys Gln Ser Val Ser Val Thr Leu Leu Ile Leu Asp Ile Ser Arg Ser
         115                 120                 125            
 Glu Val Arg Val Lys Ser Pro Pro Glu Ala Gly Thr Gln Leu Pro Lys
     130                 135                 140                
 Ile Ile Phe Ser Arg Asp Glu Lys Val Leu Gly Gln Ser Gln Glu Pro
 145                 150                 155                 160
 Asn Val Asn Pro Ala Ser Ala Gly Asn Gln Thr Gln Lys Thr Gln Asp
                 165                 170                 175    
 Gly Gly Lys Ser Lys Arg Ser Thr Val Asp Ser Lys Ala Met Gly Glu
             180                 185                 190        
 Lys Ser Phe Ser Val His Asn Asn Gly Gly Ala Val Ser Phe Gln Phe
         195                 200                 205            
 Phe Phe Asn Ile Ser Thr Asp Asp Gln Glu Gly Leu Tyr Ser Leu Tyr
     210                 215                 220                
 Phe His Lys Cys Leu Gly Lys Glu Leu Pro Ser Asp Lys Phe Thr Phe
 225                 230                 235                 240
 Ser Leu Asp Ile Glu Ile Thr Glu Lys Asn Pro Asp Ser Tyr Leu Ser
                 245                 250                 255    
 Ala Gly Glu Ile Pro Leu Pro Lys Leu Tyr Ile Ser Met Ala Phe Phe
             260                 265                 270        
 Phe Phe Leu Ser Gly Thr Ile Trp Ile His Ile Leu Arg Lys Arg Arg
         275                 280                 285            
 Asn Asp Val Phe Lys Ile His Trp Leu Met Ala Ala Leu Pro Phe Thr
     290                 295                 300                
 Lys Ser Leu Ser Leu Val Phe His Ala Ile Asp Tyr His Tyr Ile Ser
 305                 310                 315                 320
 Ser Gln Gly Phe Pro Ile Glu Gly Trp Ala Val Val Tyr Tyr Ile Thr
                 325                 330                 335    
 His Leu Leu Lys Gly Ala Leu Leu Phe Ile Thr Ile Ala Leu Ile Gly
             340                 345                 350        
 Thr Gly Trp Ala Phe Ile Lys His Ile Leu Ser Asp Lys Asp Lys Lys
         355                 360                 365            
 Ile Phe Met Ile Val Ile Pro Leu Gln Val Leu Ala Asn Val Ala Tyr
     370                 375                 380                
 Ile Ile Ile Glu Ser Thr Glu Glu Gly Thr Thr Glu Tyr Gly Leu Trp
 385                 390                 395                 400
 Lys Asp Ser Leu Phe Leu Val Asp Leu Leu Cys Cys Gly Ala Ile Leu
                 405                 410                 415    
 Phe Pro Val Val Trp Ser Ile Arg His Leu Gln Glu Ala Ser Ala Thr
             420                 425                 430        
 Asp Gly Lys Gly Lys Phe Ser Arg Ala His Phe Val Leu Leu Ser Leu
         435                 440                 445            
 Leu
    



      <210> 490
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 490
 Met Ser Arg Leu Asn Trp Lys Pro Phe Val Tyr Asp Gly Leu Ala Ser
   1               5                  10                  15    
 Ile Thr Ala Glu Phe Gly Thr Phe Pro Met Asp Leu Ala Lys Thr Arg
              20                  25                  30        
 Leu Arg Gln Ala Ser Tyr Gly Thr Ile Lys Ile Gly Ile Tyr Gln Ser
          35                  40                  45            
 Leu Lys Gln Leu Ser Val Glu Arg Leu Glu Asp Glu Thr Leu Leu Ile
      50                  55                  60                
 Asn Met Ile Cys Gly Val Val Ser Gly Val Ile Phe Ser Thr Ile Ala
  65                  70                  75                  80
 Asn Pro Thr Asp Val Leu Lys Ile Arg Met Gln Ala Gln Gly Ser Leu
                  85                  90                  95    
 Phe Gln Gly Ser Met Ile Gly Ser Phe Ile Asp Ile Tyr Gln Gln Glu
             100                 105                 110        
 Gly Thr Arg Gly Leu Trp Arg Ser Val Val Pro Thr Ala Gln His Ala
         115                 120                 125            
 Ala Ile Val Val Gly Val Glu Leu Pro Val Tyr Asp Phe Thr Lys Lys
     130                 135                 140                
 His Leu Ile Leu Ser Gly Met Met Glu Asp Thr Thr Leu Thr His Phe
 145                 150                 155                 160
 Val Ser Ser Phe Thr Tyr Gly Leu Ala Gly Ala Leu Ala Ser Asn Pro
                 165                 170                 175    
 Gly Asp Val Ala Gly Thr His Val Met Asn Gln Arg Ala Ile Val Gly
             180                 185                 190        
 His Val Asp Leu Tyr Lys Gly Thr Leu Asp Gly Ile Leu Lys Met Trp
         195                 200                 205            
 Lys His Glu Gly Phe Phe Val Phe Lys Gly Phe Trp Pro Asn Trp Leu
     210                 215                 220                
 Trp Arg Gly Pro Trp Asn Ile Ile Leu
 225                 230            



      <210> 491
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 491
 Met Glu Ser Gly Asn Gln Ser Thr Val Thr Glu Phe Ile Phe Thr Gly
   1               5                  10                  15    
 Phe Pro Gln Leu Gln Asp Gly Ser Leu Leu Tyr Phe Phe Pro Leu Leu
              20                  25                  30        
 Phe Ile Tyr Thr Phe Ile Ile Ile Asp Asn Leu Leu Ile Phe Ser Ala
          35                  40                  45            
 Val Arg Leu Asp Thr His Leu His Asn Pro Met Tyr Asn Phe Ile Ser
      50                  55                  60                
 Ile Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys
  65                  70                  75                  80
 Met Leu Ser Asn Leu Ile Ser Glu Lys Lys Ala Ile Ser Met Thr Gly
                  85                  90                  95    
 Cys Ile Leu Gln Met Tyr Phe Phe His Ser Leu Glu Asn Ser Glu Gly
             100                 105                 110        
 Ile Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn
         115                 120                 125            
 Pro Leu Arg Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala Gln Leu
     130                 135                 140                
 Ser Ala Gly Ser Cys Leu Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile
 145                 150                 155                 160
 Val Met Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln
                 165                 170                 175    
 Ile Phe Cys Asp Leu Val Pro Val Leu Ser Leu Ala Cys Thr Asp Thr
             180                 185                 190        
 Ser Met Ile Leu Ile Glu Asp Val Ile His Ala Val Thr Ile Ile Ile
         195                 200                 205            
 Thr Phe Leu Ile Ile Ala Leu Ser Tyr Val Arg Ile Val Thr Val Ile
     210                 215                 220                
 Leu Arg Ile Pro Ser Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys
 225                 230                 235                 240
 Ala Gly His Leu Met Val Phe Leu Ile Phe Phe Gly Ser Val Ser Leu
                 245                 250                 255    
 Met Tyr Leu Arg Phe Ser Asp Thr Tyr Pro Pro Val Leu Asp Thr Ala
             260                 265                 270        
 Ile Ala Leu Met Phe Thr Val Leu Ala Pro Phe Phe Asn Pro Ile Ile
         275                 280                 285            
 Tyr Ser Leu Arg Asn Lys Asp Met Asn Asn Ala Ile Lys Lys Leu Phe
     290                 295                 300                
 Cys Leu Gln Lys Val Leu Asn Lys Pro Gly Gly
 305                 310                 315



      <210> 492
      <211> 278
      <212> PRT
      <213> Homo sapiens


      <400> 492
 Met Glu Pro Ser Gln Cys Val Glu Glu Leu Glu Asp Asp Val Phe Gln
   1               5                  10                  15    
 Pro Glu Asp Gly Glu Pro Val Thr Gln Pro Gly Ser Leu Leu Ser Ala
              20                  25                  30        
 Asp Leu Phe Ala Gln Ser Leu Leu Asp Cys Pro Leu Ser Arg Leu Gln
          35                  40                  45            
 Leu Phe Pro Leu Thr His Cys Cys Gly Pro Gly Leu Arg Pro Thr Ser
      50                  55                  60                
 Gln Glu Asp Lys Ala Thr Gln Thr Leu Ser Pro Ala Ser Pro Ser Gln
  65                  70                  75                  80
 Gly Val Met Leu Pro Cys Gly Val Thr Glu Glu Pro Gln Arg Leu Phe
                  85                  90                  95    
 Tyr Gly Asn Ala Gly Tyr Arg Leu Pro Leu Pro Ala Ser Phe Pro Ala
             100                 105                 110        
 Val Leu Pro Ile Gly Glu Gln Pro Pro Glu Gly Gln Trp Gln His Gln
         115                 120                 125            
 Ala Glu Val Gln Ile Ala Arg Lys Leu Gln Cys Ile Ala Asp Gln Phe
     130                 135                 140                
 His Arg Leu His Val Gln Gln His Gln Gln Asn Gln Asn Arg Val Trp
 145                 150                 155                 160
 Trp Gln Ile Leu Leu Phe Leu His Asn Leu Ala Leu Asn Gly Glu Glu
                 165                 170                 175    
 Asn Arg Asn Gly Ala Gly Pro Val Gly Glu Gly Gly Leu Pro Ser Ser
             180                 185                 190        
 His Gly Ala Pro Gly Thr Pro Ser Gly Thr Gly Arg Thr Ser Gly Arg
         195                 200                 205            
 Thr Asp Thr Val Ser Cys Glu Ile Val Phe Leu Leu Leu Phe Cys Val
     210                 215                 220                
 Leu Ile Phe Phe Asn Phe Ser Leu Ser Val His Thr Thr Tyr Ser Ser
 225                 230                 235                 240
 Gly Thr Phe Phe Leu Cys Gln Ala Leu Asp Leu Glu Trp Gly Pro Leu
                 245                 250                 255    
 Ser Asn Thr Val Glu Gly Glu Ala Asp Val Ser Val Met Val Arg Ile
             260                 265                 270        
 Pro Lys Gly Ser Asp Lys
         275            



      <210> 493
      <211> 396
      <212> PRT
      <213> Homo sapiens


      <400> 493
 Met Ser Ser Ile Pro His Ser Val Asp Thr Lys Ala Leu Gly Pro Glu
   1               5                  10                  15    
 Gly His Gly Thr Gly Ile Ala Ala Val Ala Ser Tyr Leu Gln Ala Ile
              20                  25                  30        
 Ala Gly Ala Glu Glu Ala Ala Arg Ala Gln Ala Pro Glu His Pro Lys
          35                  40                  45            
 Gly Ile Thr Cys Trp Ile Ala Leu Tyr Ala Val Glu Ala Leu Pro Thr
      50                  55                  60                
 Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg Ser Leu Glu Val Asp Cys
  65                  70                  75                  80
 Ser Gly Leu Gly Leu Thr Thr Val Pro Pro Asp Val Pro Ala Ala Thr
                  85                  90                  95    
 Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu Ser Ala Leu Pro Ser Trp
             100                 105                 110        
 Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg Leu Asp Leu Ser Asn Asn
         115                 120                 125            
 Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe Gly Asp Leu Thr Asn Leu
     130                 135                 140                
 Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile Arg Thr Leu Asp Arg Asp
 145                 150                 155                 160
 Leu Leu Arg His Ser Pro Leu Leu Arg His Leu Asp Leu Ser Ile Asn
                 165                 170                 175    
 Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe Asp Gly Leu Leu Ala Leu
             180                 185                 190        
 Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu Gln Asn Leu Asp Arg Leu
         195                 200                 205            
 Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu Leu Gln Val Gly Asp Asn
     210                 215                 220                
 Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu Phe Lys His Trp Met Glu
 225                 230                 235                 240
 Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp Gln Leu Ala Cys Thr Leu
                 245                 250                 255    
 Pro Lys Glu Leu Arg Gly Lys Asp Met Arg Met Val Pro Met Glu Met
             260                 265                 270        
 Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu Asn Ser Ser Ala Gly Leu
         275                 280                 285            
 Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala Ser Pro Glu Pro Ala Lys
     290                 295                 300                
 Pro Lys Pro Gly Val Glu Pro Glu Pro Glu Pro Ser Thr Ala Cys Pro
 305                 310                 315                 320
 Gln Lys Gln Arg His Arg Pro Ala Ser Val Arg Arg Ala Met Gly Thr
                 325                 330                 335    
 Val Ile Ile Ala Gly Val Val Cys Gly Val Val Cys Ile Met Met Val
             340                 345                 350        
 Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala Ser Leu Met Ala Lys Tyr
         355                 360                 365            
 His Arg Glu Leu Lys Lys Arg Gln Pro Leu Met Gly Asp Pro Glu Gly
     370                 375                 380                
 Glu His Glu Asp Gln Lys Gln Ile Ser Ser Val Ala
 385                 390                 395    



      <210> 494
      <211> 382
      <212> PRT
      <213> Homo sapiens


      <400> 494
 Met Ala Leu Thr Leu Leu Glu Asp Trp Cys Lys Gly Met Asp Met Asp
   1               5                  10                  15    
 Pro Arg Lys Ala Leu Leu Ile Val Gly Ile Pro Met Glu Cys Ser Glu
              20                  25                  30        
 Val Glu Ile Gln Asp Thr Val Lys Ala Gly Leu Gln Pro Leu Cys Ala
          35                  40                  45            
 Tyr Arg Val Leu Gly Arg Met Phe Arg Arg Glu Asp Asn Ala Lys Ala
      50                  55                  60                
 Val Phe Ile Glu Leu Ala Asp Thr Val Asn Tyr Thr Thr Leu Pro Ser
  65                  70                  75                  80
 His Ile Pro Gly Lys Gly Gly Ser Trp Glu Val Val Val Lys Pro Arg
                  85                  90                  95    
 Asn Pro Asp Asp Glu Phe Leu Ser Arg Leu Asn Tyr Phe Leu Lys Asp
             100                 105                 110        
 Glu Gly Arg Ser Met Thr Asp Val Ala Arg Ala Leu Gly Cys Cys Ser
         115                 120                 125            
 Leu Pro Ala Glu Ser Leu Asp Ala Glu Val Met Pro Gln Val Arg Ser
     130                 135                 140                
 Pro Pro Leu Glu Pro Pro Lys Glu Ser Glu Glu Thr Phe Glu Asp Trp
 145                 150                 155                 160
 Leu Glu Gln Val Thr Glu Ile Met Pro Ile Trp Gln Val Ser Glu Val
                 165                 170                 175    
 Glu Lys Arg Arg Arg Leu Leu Glu Ser Leu Arg Gly Pro Ala Leu Ser
             180                 185                 190        
 Ile Met Arg Val Leu Gln Ala Asn Asn Asp Ser Ile Thr Val Glu Gln
         195                 200                 205            
 Cys Leu Asp Ala Leu Lys Gln Ile Phe Gly Asp Lys Glu Asp Phe Arg
     210                 215                 220                
 Ala Ser Gln Phe Arg Phe Leu Gln Thr Ser Pro Lys Ile Gly Glu Lys
 225                 230                 235                 240
 Val Ser Thr Phe Leu Leu Arg Leu Glu Pro Leu Leu Gln Lys Ala Val
                 245                 250                 255    
 His Lys Ser Pro Leu Ser Val Arg Ser Thr Asp Met Ile Arg Leu Lys
             260                 265                 270        
 His Leu Leu Ala Arg Val Ala Met Thr Pro Ala Leu Arg Gly Lys Leu
         275                 280                 285            
 Glu Leu Leu Asp Gln Arg Gly Cys Pro Pro Asn Phe Leu Glu Leu Met
     290                 295                 300                
 Lys Leu Ile Arg Asp Glu Glu Glu Trp Glu Asn Thr Glu Ala Val Met
 305                 310                 315                 320
 Lys Asn Lys Glu Lys Pro Ser Gly Arg Gly Arg Gly Ala Ser Gly Ser
                 325                 330                 335    
 Ser Glu Asn Leu Ser Ile His Tyr Leu Val Arg Ile Gln His Pro Leu
             340                 345                 350        
 Trp Pro Phe Trp Thr Pro Asp Val His Leu Phe Leu Ala Trp Asp His
         355                 360                 365            
 Leu Leu Leu Phe Ile Cys Ile Ser Leu Leu Gly His Lys Lys
     370                 375                 380        



      <210> 495
      <211> 386
      <212> PRT
      <213> Homo sapiens


      <400> 495
 Met Ala Gly Tyr Glu Tyr Val Ser Pro Glu Gln Leu Ala Gly Phe Asp
   1               5                  10                  15    
 Lys Tyr Lys Tyr Ser Ala Val Asp Thr Asn Pro Leu Ser Leu Tyr Val
              20                  25                  30        
 Met His Pro Phe Trp Asn Thr Ile Val Lys Val Phe Pro Thr Trp Leu
          35                  40                  45            
 Ala Pro Asn Leu Ile Thr Phe Ser Gly Phe Leu Leu Val Val Phe Asn
      50                  55                  60                
 Phe Leu Leu Met Ala Tyr Phe Asp Pro Asp Phe Tyr Ala Ser Ala Pro
  65                  70                  75                  80
 Gly His Lys His Val Pro Asp Trp Val Trp Ile Val Val Gly Ile Leu
                  85                  90                  95    
 Asn Phe Val Ala Tyr Thr Leu Asp Gly Val Asp Gly Lys Gln Ala Arg
             100                 105                 110        
 Arg Thr Asn Ser Ser Thr Pro Leu Gly Glu Leu Phe Asp His Gly Leu
         115                 120                 125            
 Asp Ser Trp Ser Cys Val Tyr Phe Val Val Thr Val Tyr Ser Ile Phe
     130                 135                 140                
 Gly Arg Gly Ser Thr Gly Val Ser Val Phe Val Leu Tyr Leu Leu Leu
 145                 150                 155                 160
 Trp Val Val Leu Phe Ser Phe Ile Leu Ser His Trp Glu Lys Tyr Asn
                 165                 170                 175    
 Thr Gly Ile Leu Phe Leu Pro Trp Gly Tyr Asp Ile Ser Gln Val Thr
             180                 185                 190        
 Ile Ser Phe Val Tyr Ile Val Thr Ala Val Val Gly Val Glu Ala Trp
         195                 200                 205            
 Tyr Glu Pro Phe Leu Phe Asn Phe Leu Tyr Arg Asp Leu Phe Thr Ala
     210                 215                 220                
 Met Ile Ile Gly Cys Ala Leu Cys Val Thr Leu Pro Met Ser Leu Leu
 225                 230                 235                 240
 Asn Phe Phe Arg Ser Tyr Lys Asn Asn Thr Leu Lys Leu Asn Ser Val
                 245                 250                 255    
 Tyr Glu Ala Met Val Pro Leu Phe Ser Pro Cys Leu Leu Phe Ile Leu
             260                 265                 270        
 Ser Thr Ala Trp Ile Leu Trp Ser Pro Ser Asp Ile Leu Glu Leu His
         275                 280                 285            
 Pro Arg Val Phe Tyr Phe Met Val Gly Thr Ala Phe Ala Asn Ser Thr
     290                 295                 300                
 Cys Gln Leu Ile Val Cys Gln Met Ser Ser Thr Arg Cys Pro Thr Leu
 305                 310                 315                 320
 Asn Trp Leu Leu Val Pro Leu Phe Leu Val Val Leu Val Val Asn Leu
                 325                 330                 335    
 Gly Val Ala Ser Tyr Val Glu Ser Ile Leu Leu Tyr Thr Leu Thr Thr
             340                 345                 350        
 Ala Phe Thr Leu Ala His Ile His Tyr Gly Val Arg Val Val Lys Gln
         355                 360                 365            
 Leu Ser Ser His Phe Gln Ile Tyr Pro Phe Ser Leu Arg Lys Pro Asn
     370                 375                 380                
 Ser Asp
 385    



      <210> 496
      <211> 242
      <212> PRT
      <213> Homo sapiens


      <400> 496
 Met Arg Gln Leu Glu Asn Ala Gly Gln His His Thr Leu Gln Phe Thr
   1               5                  10                  15    
 Leu Pro Ser Ser Cys Ala Asn Trp Asn His Pro Leu Ala Val Leu Arg
              20                  25                  30        
 Asn Gly Pro Gln Cys Cys Cys Gly Cys Val Lys Ser Pro Phe Ile Leu
          35                  40                  45            
 Lys Ser Ser Leu Leu Pro Leu Asp Tyr Phe Asn Thr Val Ile Ser Leu
      50                  55                  60                
 Phe Ala Ser Arg Lys Gly Thr Asn Val Pro Ile Pro Leu Phe Cys Cys
  65                  70                  75                  80
 Val Pro Leu Ala Gln Arg Ser Lys Ala Val Arg Gly Trp Ala Glu Thr
                  85                  90                  95    
 Trp Glu Glu Ser Pro Ser Pro Ile His Ser Thr Gln Arg Gln Cys Thr
             100                 105                 110        
 Gln Arg Asn Asp Met Glu Ile Asp Ala Gly Arg Leu Val Pro Ala Val
         115                 120                 125            
 Ile Asn Glu Asn Ser Lys Tyr Lys Ala Asp His Asn Gly Cys Cys Lys
     130                 135                 140                
 Asn Val Asp Trp Gly Lys Gly Phe Phe Ile Leu Phe Phe Ile Leu Leu
 145                 150                 155                 160
 Ile Met Phe Leu Gly Asp Gly Arg Trp Cys Val Phe Phe Ser Ser Trp
                 165                 170                 175    
 Phe Ser Phe Ala Gln Ala His Lys Arg Asp Phe Cys Leu Leu Tyr His
             180                 185                 190        
 Glu Gln Arg Asn Cys Pro His Thr Val Asn His Glu Gln Cys Cys Cys
         195                 200                 205            
 Cys Phe Phe Lys Gln Tyr Ile Trp Trp Ser Leu Cys Leu Leu Leu Phe
     210                 215                 220                
 Pro Val Arg Ser Ser Gly Phe Ser Phe Val Phe Lys Lys Asn Ser Lys
 225                 230                 235                 240
 Lys Asp
        



      <210> 497
      <211> 339
      <212> PRT
      <213> Homo sapiens


      <400> 497
 Met Ser Gly Gln Leu Glu Arg Cys Glu Arg Glu Trp His Glu Leu Glu
   1               5                  10                  15    
 Gly Glu Phe Gln Glu Leu Gln Glu Thr His Arg Ile Tyr Lys Gln Lys
              20                  25                  30        
 Leu Glu Glu Leu Ala Ala Leu Gln Thr Leu Cys Ser Ser Ser Ile Ser
          35                  40                  45            
 Lys Gln Lys Lys His Leu Lys Asp Leu Lys Leu Thr Leu Gln Arg Cys
      50                  55                  60                
 Lys Arg His Ala Ser Arg Glu Glu Ala Glu Leu Val Gln Gln Met Ala
  65                  70                  75                  80
 Ala Asn Ile Lys Glu Arg Gln Asp Val Phe Phe Asp Met Glu Ala Tyr
                  85                  90                  95    
 Leu Pro Lys Lys Asn Gly Leu Tyr Leu Asn Leu Val Leu Gly Asn Val
             100                 105                 110        
 Asn Val Thr Leu Leu Ser Asn Gln Ala Lys Phe Ala Tyr Lys Asp Glu
         115                 120                 125            
 Tyr Glu Lys Phe Lys Leu Tyr Leu Thr Ile Ile Leu Leu Leu Gly Ala
     130                 135                 140                
 Val Ala Cys Arg Phe Val Leu His Tyr Arg Val Thr Asp Glu Val Phe
 145                 150                 155                 160
 Asn Phe Leu Leu Val Trp Tyr Tyr Cys Thr Leu Thr Ile Arg Glu Ser
                 165                 170                 175    
 Ile Leu Ile Ser Asn Gly Ser Arg Ile Lys Gly Trp Trp Val Ser His
             180                 185                 190        
 His Tyr Val Ser Thr Phe Leu Ser Gly Val Met Leu Thr Trp Pro Asn
         195                 200                 205            
 Gly Pro Ile Tyr Gln Lys Phe Arg Asn Gln Phe Leu Ala Phe Ser Ile
     210                 215                 220                
 Phe Gln Ser Cys Val Gln Phe Leu Gln Tyr Tyr Tyr Gln Arg Gly Cys
 225                 230                 235                 240
 Leu Tyr Arg Leu Arg Ala Leu Gly Glu Arg Asn His Leu Asp Leu Thr
                 245                 250                 255    
 Val Glu Gly Phe Gln Ser Trp Met Trp Arg Gly Leu Thr Phe Leu Leu
             260                 265                 270        
 Pro Phe Leu Phe Cys Gly His Phe Trp Gln Leu Tyr Asn Ala Val Thr
         275                 280                 285            
 Leu Phe Glu Leu Ser Ser His Glu Glu Cys Arg Glu Trp Gln Val Phe
     290                 295                 300                
 Val Leu Ala Phe Thr Phe Leu Ile Leu Phe Leu Gly Asn Phe Leu Thr
 305                 310                 315                 320
 Thr Leu Lys Val Val His Ala Lys Leu Gln Lys Asn Arg Gly Lys Thr
                 325                 330                 335    
 Lys Gln Pro
            



      <210> 498
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 498
 Met Cys Gly Pro Arg Arg Leu Ala Ala Pro Gly Ser Ser Leu Gly Ser
   1               5                  10                  15    
 Phe Gly Arg Ala Ser Arg Gly Gly Arg Arg Gly Ser Ser Gly Gly Arg
              20                  25                  30        
 Ala Ala Glu Pro Gly Leu Gly Asp Thr Met Arg Arg Val Leu Arg Leu
          35                  40                  45            
 Leu Leu Gly Cys Phe Leu Thr Glu Leu Cys Ala Arg Val Cys Arg Ala
      50                  55                  60                
 Gln Glu Arg Ala Gly His Gly Gln Leu Ala Gln Leu Gly Gly Val Leu
  65                  70                  75                  80
 Leu Leu Ala Gly Gly Asn Arg Ser Gly Ala Ala Ser Gly Glu Ala Ser
                  85                  90                  95    
 Glu Gly Ala Glu Ala Ser Asp Ala Pro Pro Thr Arg Ala Pro Thr Pro
             100                 105                 110        
 Asp Phe Cys Arg Gly Tyr Phe Asp Val Met Gly Gln Trp Asp Pro Pro
         115                 120                 125            
 Phe Asn Cys Ser Ser Gly Asp Phe Ile Phe Cys Cys Gly Thr Cys Gly
     130                 135                 140                
 Phe Arg Phe Cys Cys Thr Phe Lys Lys Arg Arg Leu Asn Gln Ser Thr
 145                 150                 155                 160
 Cys Thr Asn Tyr Asp Thr Pro Leu Trp Leu Asn Thr Gly Lys Pro Pro
                 165                 170                 175    
 Ala Arg Lys Asp Asp Pro Leu His Asp Pro Thr Lys Asp Lys Thr Asn
             180                 185                 190        
 Leu Ile Val Tyr Ile Ile Cys Gly Val Val Ala Val Met Val Leu Val
         195                 200                 205            
 Gly Ile Phe Thr Lys Leu Gly Leu Glu Lys Ala His Arg Pro Gln Arg
     210                 215                 220                
 Glu His Met Ser Arg Leu Tyr Asp Asn Leu Leu Phe Thr Glu Ala Gln
 225                 230                 235                 240
 Ile Ser Phe Gln Glu Asp Glu Pro Ala Pro Gly Glu Trp Ser Val Gly
                 245                 250                 255    
 Leu Gln Thr Trp Thr Val
             260        



      <210> 499
      <211> 1594
      <212> PRT
      <213> Homo sapiens


      <400> 499
 Met Pro Lys Ile Ile Gln Thr Val Gly Gly Gly Ala Val Gln Glu Arg
   1               5                  10                  15    
 Ala Pro Glu Leu Asp Gly Gly Gly Pro Thr Glu Gln Asp Lys Ser His
              20                  25                  30        
 Ser Asn Ser Ser Thr Leu Ser Asp Arg Arg Leu Ser Asn Ser Ser Leu
          35                  40                  45            
 Cys Ser Ile Glu Glu Glu His Arg Met Val Tyr Glu Met Val Gln Arg
      50                  55                  60                
 Ile Leu Leu Ser Thr Arg Gly Tyr Val Asn Phe Val Asn Glu Val Phe
  65                  70                  75                  80
 His Gln Ala Phe Leu Leu Pro Ser Cys Glu Ile Ala Val Thr Arg Lys
                  85                  90                  95    
 Val Val Gln Val Tyr Arg Lys Trp Ile Leu Gln Asp Lys Pro Val Phe
             100                 105                 110        
 Met Glu Glu Pro Asp Arg Lys Asp Val Ala Gln Glu Asp Ala Glu Lys
         115                 120                 125            
 Leu Gly Phe Ser Glu Thr Asp Ser Lys Glu Ala Ser Ser Glu Ser Ser
     130                 135                 140                
 Gly His Lys Arg Ser Ser Ser Trp Gly Arg Thr Tyr Ser Phe Thr Ser
 145                 150                 155                 160
 Ala Met Ser Arg Gly Cys Val Thr Glu Glu Glu Asn Thr Asn Val Lys
                 165                 170                 175    
 Ala Gly Val Gln Ala Leu Leu Gln Val Phe Leu Thr Asn Ser Ala Asn
             180                 185                 190        
 Ile Phe Leu Leu Glu Pro Cys Ala Glu Val Pro Val Leu Leu Lys Glu
         195                 200                 205            
 Gln Val Asp Ala Cys Lys Ala Val Leu Ile Ile Phe Arg Arg Met Ile
     210                 215                 220                
 Met Glu Leu Thr Met Asn Lys Lys Thr Trp Glu Gln Met Leu Gln Ile
 225                 230                 235                 240
 Leu Leu Arg Ile Thr Glu Ala Val Met Gln Lys Pro Lys Asp Lys Arg
                 245                 250                 255    
 Ile Lys Asp Leu Phe Ala Gln Ser Leu Ala Gly Leu Leu Phe Arg Thr
             260                 265                 270        
 Leu Met Val Ala Trp Ile Arg Ala Asn Leu Cys Val Tyr Ile Ser Arg
         275                 280                 285            
 Glu Leu Trp Asp Asp Phe Leu Gly Val Leu Ser Phe Leu Thr Glu Trp
     290                 295                 300                
 Glu Glu Leu Ile Asn Glu Trp Ala Asn Ile Met Asp Ser Leu Thr Ala
 305                 310                 315                 320
 Val Leu Ala Arg Thr Val Tyr Gly Val Glu Met Thr Asn Leu Pro Leu
                 325                 330                 335    
 Asp Lys Leu Ser Glu Gln Lys Glu Lys Lys Gln Arg Gly Lys Gly Cys
             340                 345                 350        
 Val Leu Asp Pro Gln Lys Gly Thr Thr Val Gly Arg Ser Ser Ser Leu
         355                 360                 365            
 Ser Trp Arg Ser His Pro Asp Val Thr Glu Pro Met Arg Phe Arg Ser
     370                 375                 380                
 Ala Thr Thr Ser Gly Ala Pro Gly Val Glu Lys Ala Arg Asn Ile Val
 385                 390                 395                 400
 Arg Gln Lys Ala Thr Glu Val Glu Glu Cys Gln Gln Ser Glu Asn Ala
                 405                 410                 415    
 Pro Ala Ala Gly Ser Gly His Leu Thr Val Gly Gln Gln Gln Gln Val
             420                 425                 430        
 Leu Arg Ser Ser Ser Thr Ser Asp Ile Pro Glu Pro Leu Cys Ser Asp
         435                 440                 445            
 Ser Ser Gln Gly Gln Lys Ala Glu Asn Thr Gln Asn Ser Ser Ser Ser
     450                 455                 460                
 Glu Pro Gln Pro Ile Gln Glu Asn Lys Gly His Val Lys Arg Glu His
 465                 470                 475                 480
 Glu Gly Ile Thr Ile Leu Val Arg Arg Ser Ser Ser Pro Ala Glu Leu
                 485                 490                 495    
 Asp Leu Lys Asp Asp Leu Gln Gln Thr Gln Gly Lys Cys Arg Glu Arg
             500                 505                 510        
 Gln Lys Ser Glu Ser Thr Asn Ser Asp Thr Thr Leu Gly Cys Thr Asn
         515                 520                 525            
 Glu Ala Glu Leu Ser Met Gly Pro Trp Gln Thr Cys Glu Glu Asp Pro
     530                 535                 540                
 Glu Leu Asn Thr Pro Thr Asp Val Val Ala Asp Ala Asp Ala Arg His
 545                 550                 555                 560
 Trp Leu Gln Leu Ser Pro Thr Asp Ala Ser Asn Leu Thr Asp Ser Ser
                 565                 570                 575    
 Glu Cys Leu Thr Asp Asp Cys Ser Ile Ile Ala Gly Gly Ser Leu Thr
             580                 585                 590        
 Gly Trp His Pro Asp Ser Ala Ala Val Leu Trp Arg Arg Val Leu Gly
         595                 600                 605            
 Ile Leu Gly Asp Val Asn Asn Ile Gln Ser Pro Lys Ile His Ala Arg
     610                 615                 620                
 Val Phe Cys Tyr Leu Tyr Glu Leu Trp Tyr Lys Leu Ala Lys Ile Arg
 625                 630                 635                 640
 Asp Asn Leu Ala Ile Ser Leu Asp Asn Gln Ser Ser Pro Ser Pro Pro
                 645                 650                 655    
 Val Leu Ile Pro Pro Leu Arg Met Phe Ala Ser Trp Leu Phe Lys Ala
             660                 665                 670        
 Ala Thr Leu Pro Asn Glu Tyr Lys Glu Gly Lys Leu Gln Ala Tyr Arg
         675                 680                 685            
 Leu Ile Cys Ala Met Met Thr Arg Arg Gln Asp Val Leu Pro Asn Ser
     690                 695                 700                
 Asp Phe Leu Val His Phe Tyr Leu Val Met His Leu Gly Leu Thr Ser
 705                 710                 715                 720
 Glu Asp Gln Asp Ile Leu Asn Thr Ile Ile Arg His Cys Pro Pro Arg
                 725                 730                 735    
 Phe Phe Ser Leu Gly Phe Pro Gly Phe Ser Met Leu Val Gly Asp Phe
             740                 745                 750        
 Ile Thr Ala Ala Ala Arg Val Leu Ser Thr Asp Ile Leu Thr Ala Pro
         755                 760                 765            
 Arg Ser Glu Ala Val Thr Val Leu Gly Ser Leu Val Cys Phe Pro Asn
     770                 775                 780                
 Thr Tyr Gln Glu Ile Pro Leu Leu Gln Ser Val Pro Glu Val Asn Glu
 785                 790                 795                 800
 Ala Ile Thr Gly Thr Glu Asp Val Lys His Tyr Leu Ile Asn Ile Leu
                 805                 810                 815    
 Leu Lys Asn Ala Thr Glu Glu Pro Asn Glu Tyr Ala Arg Cys Ile Ala
             820                 825                 830        
 Val Cys Ser Leu Gly Val Trp Ile Cys Glu Glu Leu Ala Gln Cys Thr
         835                 840                 845            
 Ser His Pro Gln Val Lys Glu Ala Ile Asn Val Ile Gly Val Thr Leu
     850                 855                 860                
 Lys Phe Pro Asn Lys Ile Val Ala Gln Val Ala Cys Asp Val Leu Gln
 865                 870                 875                 880
 Leu Leu Val Ser Tyr Trp Glu Lys Leu Gln Met Phe Glu Thr Ser Leu
                 885                 890                 895    
 Pro Arg Lys Met Ala Glu Ile Leu Val Ala Thr Val Ala Phe Leu Leu
             900                 905                 910        
 Pro Ser Ala Glu Tyr Ser Ser Val Glu Thr Asp Lys Lys Phe Ile Val
         915                 920                 925            
 Ser Leu Leu Leu Cys Leu Leu Asp Trp Cys Met Ala Leu Pro Val Ser
     930                 935                 940                
 Val Leu Leu His Pro Val Ser Thr Ala Val Leu Glu Glu Gln His Ser
 945                 950                 955                 960
 Ala Arg Ala Pro Leu Leu Asp Tyr Ile Tyr Arg Val Leu His Cys Cys
                 965                 970                 975    
 Val Cys Gly Ser Ser Thr Tyr Thr Gln Gln Ser His Tyr Ile Leu Thr
             980                 985                 990        
 Leu Ala Asp Leu Ser Ser Thr Asp Tyr Asp Pro Phe Leu Pro Leu Ala
         995                1000                1005            
 Asn Val Lys Ser Ser Glu Pro Val Gln Tyr His Ser Ser Ala Glu Leu
    1010                1015                1020                
 Gly Asn Leu Leu Thr Val Glu Glu Glu Lys Lys Arg Arg Ser Leu Glu
1025                1030                1035                1040
 Leu Ile Pro Leu Thr Ala Arg Met Val Met Ala His Leu Val Asn His
                1045                1050                1055    
 Leu Gly His Tyr Pro Leu Ser Gly Gly Pro Ala Ile Leu His Ser Leu
            1060                1065                1070        
 Val Ser Glu Asn His Asp Asn Ala His Val Glu Gly Ser Glu Leu Ser
        1075                1080                1085            
 Phe Glu Val Phe Arg Ser Pro Asn Leu Gln Leu Phe Val Phe Asn Asp
    1090                1095                1100                
 Ser Thr Leu Ile Ser Tyr Leu Gln Thr Pro Thr Glu Gly Pro Val Gly
1105                1110                1115                1120
 Gly Ser Pro Val Gly Ser Leu Ser Asp Val Arg Val Ile Val Arg Asp
                1125                1130                1135    
 Ile Ser Gly Lys Tyr Ser Trp Asp Gly Lys Val Leu Tyr Gly Pro Leu
            1140                1145                1150        
 Glu Gly Cys Leu Ala Pro Asn Gly Arg Asn Pro Ser Phe Leu Ile Ser
        1155                1160                1165            
 Ser Trp His Arg Asp Thr Phe Gly Pro Gln Lys Asp Ser Ser Gln Val
    1170                1175                1180                
 Glu Glu Gly Asp Asp Val Leu Asp Lys Leu Leu Glu Asn Ile Gly His
1185                1190                1195                1200
 Thr Ser Pro Glu Cys Leu Leu Pro Ser Gln Leu Asn Leu Asn Glu Pro
                1205                1210                1215    
 Ser Leu Thr Pro Cys Gly Met Asn Tyr Asp Gln Glu Lys Glu Ile Ile
            1220                1225                1230        
 Glu Val Ile Leu Arg Gln Asn Ala Gln Glu Asp Glu Tyr Ile Gln Ser
        1235                1240                1245            
 His Asn Phe Asp Ser Ala Met Lys Val Thr Ser Gln Gly Gln Pro Ser
    1250                1255                1260                
 Pro Val Glu Pro Arg Gly Pro Phe Tyr Phe Cys Arg Leu Leu Leu Asp
1265                1270                1275                1280
 Asp Leu Gly Met Asn Ser Trp Asp Arg Arg Lys Asn Phe His Leu Leu
                1285                1290                1295    
 Lys Lys Asn Ser Lys Leu Leu Arg Glu Leu Lys Asn Leu Asp Ser Arg
            1300                1305                1310        
 Gln Cys Arg Glu Thr His Lys Ile Ala Val Phe Tyr Ile Ala Glu Gly
        1315                1320                1325            
 Gln Glu Asp Lys Cys Ser Ile Leu Ser Asn Glu Arg Gly Ser Gln Ala
    1330                1335                1340                
 Tyr Glu Asp Phe Val Ala Gly Leu Gly Trp Glu Val Asp Leu Ser Thr
1345                1350                1355                1360
 His Cys Gly Phe Met Gly Gly Leu Gln Arg Asn Gly Ser Thr Gly Gln
                1365                1370                1375    
 Thr Ala Pro Tyr Tyr Ala Thr Ser Thr Val Glu Val Ile Phe His Val
            1380                1385                1390        
 Ser Thr Arg Met Pro Ser Asp Ser Asp Asp Ser Leu Thr Lys Lys Leu
        1395                1400                1405            
 Arg His Leu Gly Asn Asp Glu Val His Ile Val Trp Ser Glu His Ser
    1410                1415                1420                
 Arg Asp Tyr Arg Arg Gly Ile Ile Pro Thr Ala Phe Gly Asp Val Ser
1425                1430                1435                1440
 Ile Ile Ile Tyr Pro Met Lys Asn His Met Phe Phe Ile Ala Ile Thr
                1445                1450                1455    
 Lys Lys Pro Glu Val Pro Phe Phe Gly Pro Leu Phe Asp Gly Ala Ile
            1460                1465                1470        
 Val Ser Gly Lys Leu Leu Pro Ser Leu Val Cys Ala Thr Cys Ile Asn
        1475                1480                1485            
 Ala Ser Arg Ala Val Lys Cys Leu Ile Pro Leu Tyr Gln Ser Phe Tyr
    1490                1495                1500                
 Glu Glu Arg Ala Leu Tyr Leu Glu Ala Ile Ile Gln Asn His Arg Glu
1505                1510                1515                1520
 Val Met Thr Phe Glu Asp Phe Ala Ala Gln Val Phe Ser Pro Ser Pro
                1525                1530                1535    
 Ser Tyr Ser Leu Ser Gly Thr Gly Ala Leu Ala Ser Ser Leu Ser Ala
            1540                1545                1550        
 Asp Leu Glu Glu Pro Leu Ser Glu Glu Glu Thr Glu His Pro Leu Leu
        1555                1560                1565            
 Pro Leu Pro Arg Ala Thr Lys Pro Arg Ile Ser Arg Lys Phe Arg Cys
    1570                1575                1580                
 Cys Thr Ser Ala Leu Ser Arg Ser Ser His
1585                1590                



      <210> 500
      <211> 234
      <212> PRT
      <213> Homo sapiens


      <400> 500
 Met Pro Ser Gly Cys His Ser Ser Pro Pro Ser Gly Leu Arg Gly Asp
   1               5                  10                  15    
 Met Ala Ser Leu Val Pro Leu Ser Pro Tyr Leu Ser Pro Thr Val Leu
              20                  25                  30        
 Leu Leu Val Ser Cys Asp Leu Gly Phe Val Arg Ala Asp Arg Pro Pro
          35                  40                  45            
 Ser Pro Val Asn Val Thr Val Thr His Leu Arg Ala Asn Ser Ala Thr
      50                  55                  60                
 Val Ser Trp Asp Val Pro Glu Gly Asn Ile Val Ile Gly Tyr Ser Ile
  65                  70                  75                  80
 Ser Gln Gln Arg Gln Asn Gly Pro Gly Gln Arg Val Ile Arg Glu Val
                  85                  90                  95    
 Asn Thr Thr Thr Arg Ala Cys Ala Leu Trp Gly Leu Ala Glu Asp Ser
             100                 105                 110        
 Asp Tyr Thr Val Gln Val Arg Ser Ile Gly Leu Arg Gly Glu Ser Pro
         115                 120                 125            
 Pro Gly Pro Arg Val His Phe Arg Thr Leu Lys Gly Ser Asp Arg Leu
     130                 135                 140                
 Pro Ser Asn Ser Ser Ser Pro Gly Asp Ile Thr Val Glu Gly Leu Asp
 145                 150                 155                 160
 Gly Glu Arg Pro Leu Gln Thr Gly Glu Val Val Ile Ile Val Val Val
                 165                 170                 175    
 Leu Leu Met Trp Ala Ala Val Ile Gly Leu Phe Cys Arg Gln Tyr Asp
             180                 185                 190        
 Ile Ile Lys Asp Asn Asp Ser Asn Asn Asn Pro Lys Glu Lys Gly Lys
         195                 200                 205            
 Gly Pro Glu Gln Ser Pro Gln Gly Arg Pro Val Gly Thr Arg Gln Lys
     210                 215                 220                
 Lys Ser Pro Ser Ile Asn Thr Ile Asp Val
 225                 230                



      <210> 501
      <211> 551
      <212> PRT
      <213> Homo sapiens


      <400> 501
 Met Asp Leu Glu Gly Ile Glu Arg Arg Ser Phe Ser His Glu Glu Val
   1               5                  10                  15    
 Lys Arg Val Arg Ala Met Pro Cys Val Gln Ala Gln Tyr Gly Ser Ser
              20                  25                  30        
 Pro Gln Gly Ala Ser Pro Ala Ser Gln Ser Tyr Ser Tyr His Ser Ser
          35                  40                  45            
 Gly Glu Tyr Ser Ser Asp Phe Leu Thr Pro Glu Phe Val Lys Phe Ser
      50                  55                  60                
 Met Asp Leu Thr Asn Thr Glu Ile Thr Ala Thr Thr Ser Leu Pro Ser
  65                  70                  75                  80
 Phe Ser Thr Phe Met Asp Asn Tyr Ser Thr Gly Tyr Asp Val Lys Pro
                  85                  90                  95    
 Pro Cys Leu Tyr Gln Met Pro Leu Ser Gly Gln Gln Ser Ser Ile Lys
             100                 105                 110        
 Val Glu Asp Ile Gln Met His Asn Tyr Gln Gln His Ser His Leu Pro
         115                 120                 125            
 Pro Gln Ser Glu Glu Met Met Pro His Ser Gly Ser Val Tyr Tyr Lys
     130                 135                 140                
 Pro Ser Ser Pro Pro Thr Pro Thr Thr Pro Gly Phe Gln Val Gln His
 145                 150                 155                 160
 Ser Pro Met Trp Asp Asp Pro Gly Ser Leu His Asn Phe His Gln Asn
                 165                 170                 175    
 Tyr Val Ala Thr Thr His Met Ile Glu Gln Arg Lys Thr Pro Val Ser
             180                 185                 190        
 Arg Leu Ser Leu Phe Ser Phe Lys Gln Ser Pro Pro Gly Thr Pro Val
         195                 200                 205            
 Ser Ser Cys Gln Met Arg Phe Asp Gly Pro Leu His Val Pro Met Asn
     210                 215                 220                
 Pro Glu Pro Ala Gly Ser His His Val Val Asp Gly Gln Thr Phe Ala
 225                 230                 235                 240
 Val Pro Asn Pro Ile Arg Lys Pro Ala Ser Met Gly Phe Pro Gly Leu
                 245                 250                 255    
 Gln Ile Gly His Ala Ser Gln Leu Leu Asp Thr Gln Arg Thr Val Gln
             260                 265                 270        
 Lys Asn Ala Lys Tyr Val Cys Leu Ala Asn Lys Asn Cys Pro Val Asp
         275                 280                 285            
 Lys Arg Arg Arg Asn Arg Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu
     290                 295                 300                
 Ala Val Gly Met Val Lys Glu Val Val Arg Thr Asp Ser Leu Lys Gly
 305                 310                 315                 320
 Arg Arg Gly Arg Leu Pro Ser Lys Pro Lys Ser Pro Gln Glu Pro Ser
                 325                 330                 335    
 Pro Pro Ser Pro Pro Ala Asn Pro Asp Tyr Gln Met Ser Gly Asp Asp
             340                 345                 350        
 Thr Gln His Ile Gln Gln Phe Tyr Asp Leu Leu Thr Gly Ser Met Glu
         355                 360                 365            
 Ile Ile Arg Gly Trp Ala Glu Lys Ile Pro Gly Phe Ala Asp Leu Pro
     370                 375                 380                
 Lys Ala Asp Gln Asp Leu Leu Phe Glu Ser Ala Phe Leu Glu Leu Phe
 385                 390                 395                 400
 Val Leu Arg Leu Ala Tyr Arg Ser Asn Pro Val Glu Gly Lys Leu Ile
                 405                 410                 415    
 Phe Cys Asn Gly Val Val Leu His Arg Leu Gln Cys Val Arg Gly Phe
             420                 425                 430        
 Gly Glu Trp Ile Asp Ser Ile Val Glu Phe Ser Ser Asn Leu Gln Asn
         435                 440                 445            
 Met Asn Ile Asp Ile Ser Ala Phe Ser Cys Ile Ala Ala Leu Ala Met
     450                 455                 460                
 Val Thr Glu Arg His Gly Leu Lys Glu Pro Lys Arg Val Glu Glu Leu
 465                 470                 475                 480
 Gln Asn Lys Ile Val Asn Cys Leu Lys Asp His Val Thr Phe Asn Asn
                 485                 490                 495    
 Gly Gly Leu Asn Arg Pro Asn Tyr Leu Ser Lys Leu Leu Gly Lys Leu
             500                 505                 510        
 Pro Glu Leu Arg Thr Leu Cys Thr Gln Gly Leu Gln Arg Ile Phe Tyr
         515                 520                 525            
 Leu Lys Leu Glu Asp Leu Val Pro Pro Pro Ala Ile Ile Asp Lys Leu
     530                 535                 540                
 Phe Leu Asp Thr Leu Pro Phe
 545                 550    



      <210> 502
      <211> 323
      <212> PRT
      <213> Homo sapiens


      <400> 502
 Met Ala Thr Val Asn Thr Asp Ala Thr Asp Lys Asp Ile Ser Lys Phe
   1               5                  10                  15    
 Lys Val Thr Ser Thr Leu Val Val Ser Gly Ile Glu Cys Ile Thr Gly
              20                  25                  30        
 Ile Leu Gly Ser Gly Phe Ile Thr Ala Ile Tyr Gly Ala Glu Trp Ala
          35                  40                  45            
 Arg Gly Lys Thr Leu Pro Thr Gly Asp Arg Ile Met Leu Met Leu Ser
      50                  55                  60                
 Phe Ser Arg Leu Leu Leu Gln Ile Trp Met Met Leu Glu Asn Ile Phe
  65                  70                  75                  80
 Ser Leu Leu Phe Arg Ile Val Tyr Asn Gln Asn Ser Val Tyr Ile Leu
                  85                  90                  95    
 Phe Lys Val Ile Thr Val Phe Leu Asn His Ser Asn Leu Trp Phe Ala
             100                 105                 110        
 Ala Trp Leu Lys Val Phe Tyr Cys Leu Arg Ile Ala Asn Phe Asn His
         115                 120                 125            
 Pro Leu Phe Phe Leu Met Lys Arg Lys Ile Ile Val Leu Ile Pro Trp
     130                 135                 140                
 Leu Leu Arg Leu Pro Val Leu Val Ser Leu Ser Phe Ser Phe Pro Leu
 145                 150                 155                 160
 Ser Arg Glu Val Phe Asn Val Tyr Val Asn Ser Ser Ile Pro Ile Pro
                 165                 170                 175    
 Ser Ser Asn Ser Thr Glu Lys Lys Tyr Phe Ser Glu Thr Asn Met Val
             180                 185                 190        
 Asn Leu Val Leu Phe Tyr Asn Met Gly Ile Phe Val Pro Leu Ile Met
         195                 200                 205            
 Phe Ile Leu Ala Ala Thr Leu Leu Ile Leu Ser Leu Lys Arg His Thr
     210                 215                 220                
 Leu His Met Gly Ser Asn Ala Thr Gly Ser Arg Asp Pro Ser Met Lys
 225                 230                 235                 240
 Ala His Ile Gly Ala Ile Lys Ala Thr Ser Tyr Phe Leu Ile Leu Tyr
                 245                 250                 255    
 Ile Phe Asn Ala Ile Ala Leu Phe Leu Ser Thr Ser Asn Ile Phe Asp
             260                 265                 270        
 Thr Tyr Ser Ser Trp Asn Ile Leu Cys Lys Ile Ile Met Ala Ala Tyr
         275                 280                 285            
 Pro Ala Gly His Ser Val Gln Leu Ile Leu Gly Asn Pro Gly Leu Arg
     290                 295                 300                
 Arg Ala Trp Lys Arg Phe Gln His Gln Val Pro Leu Tyr Leu Lys Gly
 305                 310                 315                 320
 Gln Thr Leu
            



      <210> 503
      <211> 1279
      <212> PRT
      <213> Homo sapiens


      <400> 503
 Met Ala Ser Ser Asn Pro Pro Pro Gln Pro Ala Ile Gly Asp Gln Leu
   1               5                  10                  15    
 Val Pro Gly Val Pro Gly Pro Ser Ser Glu Ala Glu Asp Asp Pro Gly
              20                  25                  30        
 Glu Ala Phe Glu Phe Asp Asp Ser Asp Asp Glu Glu Asp Thr Ser Ala
          35                  40                  45            
 Ala Leu Gly Val Pro Ser Leu Ala Pro Glu Arg Asp Thr Asp Pro Pro
      50                  55                  60                
 Leu Ile His Leu Asp Ser Ile Pro Val Thr Asp Pro Asp Pro Ala Ala
  65                  70                  75                  80
 Ala Pro Pro Gly Thr Gly Val Pro Ala Trp Val Ser Asn Gly Asp Ala
                  85                  90                  95    
 Ala Asp Ala Ala Phe Ser Gly Ala Arg His Ser Ser Trp Lys Arg Lys
             100                 105                 110        
 Ser Ser Arg Arg Ile Asp Arg Phe Thr Phe Pro Ala Leu Glu Glu Asp
         115                 120                 125            
 Val Ile Tyr Asp Asp Val Pro Cys Glu Ser Pro Asp Ala His Gln Pro
     130                 135                 140                
 Gly Ala Glu Arg Asn Leu Leu Tyr Glu Asp Ala His Arg Ala Gly Ala
 145                 150                 155                 160
 Pro Arg Gln Ala Glu Asp Leu Gly Trp Ser Ser Ser Glu Phe Glu Ser
                 165                 170                 175    
 Tyr Ser Glu Asp Ser Gly Glu Glu Ala Lys Pro Glu Val Glu Val Glu
             180                 185                 190        
 Pro Ala Lys His Arg Val Ser Phe Gln Pro Lys Leu Ser Pro Asp Leu
         195                 200                 205            
 Thr Arg Leu Lys Glu Arg Tyr Ala Arg Thr Lys Arg Asp Ile Leu Ala
     210                 215                 220                
 Leu Arg Val Gly Gly Arg Asp Met Gln Glu Leu Lys His Lys Tyr Asp
 225                 230                 235                 240
 Cys Lys Met Thr Gln Leu Met Lys Ala Ala Lys Ser Gly Thr Lys Asp
                 245                 250                 255    
 Gly Leu Glu Lys Thr Arg Met Ala Val Met Arg Lys Val Ser Phe Leu
             260                 265                 270        
 His Arg Lys Asp Val Leu Gly Asp Ser Glu Glu Glu Asp Met Gly Leu
         275                 280                 285            
 Leu Glu Val Ser Val Ser Asp Ile Lys Pro Pro Ala Pro Glu Leu Gly
     290                 295                 300                
 Pro Met Pro Glu Gly Leu Ser Pro Gln Gln Val Val Arg Arg His Ile
 305                 310                 315                 320
 Leu Gly Ser Ile Val Gln Ser Glu Gly Ser Tyr Val Glu Ser Leu Lys
                 325                 330                 335    
 Arg Ile Leu Gln Asp Tyr Arg Asn Pro Leu Met Glu Met Glu Pro Lys
             340                 345                 350        
 Ala Leu Ser Ala Arg Lys Cys Gln Val Val Phe Phe Arg Val Lys Glu
         355                 360                 365            
 Ile Leu His Cys His Ser Met Phe Gln Ile Ala Leu Ser Ser Arg Val
     370                 375                 380                
 Ala Glu Trp Asp Ser Thr Glu Lys Ile Gly Asp Leu Phe Val Ala Ser
 385                 390                 395                 400
 Phe Ser Lys Ser Met Val Leu Asp Val Tyr Ser Asp Tyr Val Asn Asn
                 405                 410                 415    
 Phe Thr Ser Ala Met Ser Ile Ile Lys Lys Ala Cys Leu Thr Lys Pro
             420                 425                 430        
 Ala Phe Leu Glu Phe Leu Lys Arg Arg Gln Val Cys Ser Pro Asp Arg
         435                 440                 445            
 Val Thr Leu Tyr Gly Leu Met Val Lys Pro Ile Gln Arg Phe Pro Gln
     450                 455                 460                
 Phe Ile Leu Leu Leu Gln Asp Met Leu Lys Asn Thr Pro Arg Gly His
 465                 470                 475                 480
 Pro Asp Arg Leu Ser Leu Gln Leu Ala Leu Thr Glu Leu Glu Thr Leu
                 485                 490                 495    
 Ala Glu Lys Leu Asn Glu Gln Lys Arg Leu Ala Asp Gln Val Ala Glu
             500                 505                 510        
 Ile Gln Gln Leu Thr Lys Ser Val Ser Asp Arg Ser Ser Leu Asn Lys
         515                 520                 525            
 Leu Leu Thr Ser Gly Gln Arg Gln Leu Leu Leu Cys Glu Thr Leu Thr
     530                 535                 540                
 Glu Thr Val Tyr Gly Asp Arg Gly Gln Leu Ile Lys Ser Lys Glu Arg
 545                 550                 555                 560
 Arg Val Phe Leu Leu Asn Asp Met Leu Val Cys Ala Asn Ile Asn Phe
                 565                 570                 575    
 Lys Pro Ala Asn His Arg Gly Gln Leu Glu Ile Ser Ser Leu Val Pro
             580                 585                 590        
 Leu Gly Pro Lys Tyr Val Val Lys Trp Asn Thr Ala Leu Pro Gln Val
         595                 600                 605            
 Gln Val Val Glu Val Gly Gln Asp Gly Gly Thr Tyr Asp Lys Asp Asn
     610                 615                 620                
 Val Leu Ile Gln His Ser Gly Ala Lys Lys Ala Ser Ala Ser Gly Gln
 625                 630                 635                 640
 Ala Gln Asn Lys Val Tyr Leu Gly Pro Pro Arg Leu Phe Gln Glu Leu
                 645                 650                 655    
 Gln Asp Leu Gln Lys Asp Leu Ala Val Val Glu Gln Ile Thr Leu Leu
             660                 665                 670        
 Ile Ser Thr Leu His Gly Thr Tyr Gln Asn Leu Asn Met Thr Val Ala
         675                 680                 685            
 Gln Asp Trp Cys Leu Ala Leu Gln Arg Leu Met Arg Val Lys Glu Glu
     690                 695                 700                
 Glu Ile His Ser Ala Asn Lys Cys Arg Leu Arg Leu Leu Leu Pro Gly
 705                 710                 715                 720
 Lys Pro Asp Lys Ser Gly Arg Pro Ile Ser Phe Met Val Val Phe Ile
                 725                 730                 735    
 Thr Pro Asn Pro Leu Ser Lys Ile Ser Trp Val Asn Arg Leu His Leu
             740                 745                 750        
 Ala Lys Ile Gly Leu Arg Glu Glu Asn Gln Pro Gly Trp Leu Cys Pro
         755                 760                 765            
 Asp Glu Asp Lys Lys Ser Lys Ala Pro Phe Trp Cys Pro Ile Leu Ala
     770                 775                 780                
 Cys Cys Ile Pro Ala Phe Ser Ser Arg Ala Leu Ser Leu Gln Leu Gly
 785                 790                 795                 800
 Ala Leu Val His Ser Pro Val Asn Cys Pro Leu Leu Gly Phe Ser Ala
                 805                 810                 815    
 Val Ser Thr Ser Leu Pro Gln Gly Tyr Leu Trp Val Gly Gly Gly Gln
             820                 825                 830        
 Glu Gly Ala Gly Gly Gln Val Glu Ile Phe Ser Leu Asn Arg Pro Ser
         835                 840                 845            
 Pro Arg Thr Val Lys Ser Phe Pro Leu Ala Ala Pro Val Leu Cys Met
     850                 855                 860                
 Glu Tyr Ile Pro Glu Leu Glu Glu Glu Ala Glu Ser Arg Asp Glu Ser
 865                 870                 875                 880
 Pro Thr Val Ala Asp Pro Ser Ala Thr Val His Pro Thr Ile Cys Leu
                 885                 890                 895    
 Gly Leu Gln Asp Gly Ser Ile Leu Leu Tyr Ser Ser Val Asp Thr Gly
             900                 905                 910        
 Thr Gln Cys Leu Val Ser Cys Arg Ser Pro Gly Leu Gln Pro Val Leu
         915                 920                 925            
 Cys Leu Arg His Ser Pro Phe His Leu Leu Ala Gly Leu Gln Asp Gly
     930                 935                 940                
 Thr Leu Ala Ala Tyr Pro Arg Thr Ser Gly Gly Val Leu Trp Asp Leu
 945                 950                 955                 960
 Glu Ser Pro Pro Val Cys Leu Thr Val Gly Pro Gly Pro Val Arg Thr
                 965                 970                 975    
 Leu Leu Ser Leu Glu Asp Ala Val Trp Ala Ser Cys Gly Pro Arg Val
             980                 985                 990        
 Thr Val Leu Glu Ala Thr Thr Leu Gln Pro Gln Gln Ser Phe Glu Ala
         995                1000                1005            
 His Gln Asp Glu Ala Val Ser Val Thr His Met Val Lys Ala Gly Ser
    1010                1015                1020                
 Gly Val Trp Met Ala Phe Ser Ser Gly Thr Ser Ile Arg Leu Phe His
1025                1030                1035                1040
 Thr Glu Thr Leu Glu His Leu Gln Glu Ile Asn Ile Ala Thr Arg Thr
                1045                1050                1055    
 Thr Phe Leu Leu Pro Gly Gln Lys His Leu Cys Val Thr Ser Leu Leu
            1060                1065                1070        
 Ile Cys Gln Gly Leu Leu Trp Val Gly Thr Asp Gln Gly Val Ile Val
        1075                1080                1085            
 Leu Leu Pro Val Pro Arg Leu Glu Gly Ile Pro Lys Ile Thr Gly Lys
    1090                1095                1100                
 Gly Met Val Ser Leu Asn Gly His Cys Gly Pro Val Ala Phe Leu Ala
1105                1110                1115                1120
 Val Ala Thr Ser Ile Leu Ala Pro Asp Ile Leu Arg Ser Asp Gln Glu
                1125                1130                1135    
 Glu Ala Glu Gly Pro Arg Ala Glu Glu Asp Lys Pro Asp Gly Gln Ala
            1140                1145                1150        
 His Glu Pro Met Pro Asp Ser His Val Gly Arg Glu Leu Thr Arg Lys
        1155                1160                1165            
 Lys Gly Ile Leu Leu Gln Tyr Arg Leu Arg Ser Thr Ala His Leu Pro
    1170                1175                1180                
 Gly Pro Leu Leu Ser Met Arg Glu Pro Ala Pro Ala Asp Gly Ala Ala
1185                1190                1195                1200
 Leu Glu His Ser Glu Glu Asp Gly Ser Ile Tyr Glu Met Ala Asp Asp
                1205                1210                1215    
 Pro Asp Val Trp Val Arg Ser Arg Pro Cys Ala Arg Asp Ala His Arg
            1220                1225                1230        
 Lys Glu Ile Cys Ser Val Ala Ile Ile Ser Gly Gly Gln Gly Tyr Arg
        1235                1240                1245            
 Asn Phe Gly Ser Ala Leu Gly Ser Ser Gly Arg Gln Ala Pro Cys Gly
    1250                1255                1260                
 Glu Thr Asp Ser Thr Leu Leu Ile Trp Gln Val Pro Leu Met Leu
1265                1270                1275                



      <210> 504
      <211> 698
      <212> PRT
      <213> Homo sapiens


      <400> 504
 Met Asp Ile Asn Trp Leu His Leu Tyr Val Lys Asn Tyr Cys Lys Gln
   1               5                  10                  15    
 Leu Ala Ala Gly Leu Arg Glu Asp Gln Ser Pro Ser Cys Pro Ser Glu
              20                  25                  30        
 Ile Thr Pro Ser Ile Gln Asn Tyr Ile Ala Cys Thr Ala Phe Leu Arg
          35                  40                  45            
 Ala His Ser Arg Ala Trp Cys Gly Gln Cys Arg Gly Pro His Thr Cys
      50                  55                  60                
 Gly Pro Ala Asp Gly Ala Trp Tyr Met Leu Ala Gln Phe Thr Gly Gly
  65                  70                  75                  80
 Trp Thr Cys Ile Ala Thr Ile Ala Phe His Asp Leu Gln Gly Ser Lys
                  85                  90                  95    
 Glu Val Phe Met Ala Pro Lys Ala Ser Gln Ala Ala Glu Ser Ser Ala
             100                 105                 110        
 Phe Gly Glu Lys His Asp Asn Cys Thr Thr Asn Ser Ser Thr Ser Glu
         115                 120                 125            
 Asn Arg Ala Ser Cys Ser Phe Phe Leu Pro Arg Ile Thr Ile Pro Asp
     130                 135                 140                
 Asn Tyr Thr Ile Glu Val Glu Ala Glu Asn Gly Asp Gly Val Ile Lys
 145                 150                 155                 160
 Ser His Met Thr Tyr Trp Arg Leu Glu Asn Ile Ala Lys Thr Glu Pro
                 165                 170                 175    
 Pro Lys Ile Phe Arg Val Lys Pro Val Leu Gly Ile Lys Arg Met Ile
             180                 185                 190        
 Gln Ile Glu Trp Ile Lys Pro Glu Leu Ala Pro Val Ser Ser Asp Leu
         195                 200                 205            
 Lys Tyr Thr Leu Arg Phe Arg Thr Val Asn Ser Thr Ser Trp Met Glu
     210                 215                 220                
 Val Asn Phe Ala Lys Asn Arg Lys Asp Lys Asn Gln Thr Tyr Asn Leu
 225                 230                 235                 240
 Thr Gly Leu Gln Pro Phe Thr Glu Tyr Val Ile Ala Leu Arg Cys Ala
                 245                 250                 255    
 Val Lys Glu Ser Lys Phe Trp Ser Asp Trp Ser Gln Glu Lys Met Gly
             260                 265                 270        
 Met Thr Glu Glu Glu Ala Pro Cys Gly Leu Glu Leu Trp Arg Val Leu
         275                 280                 285            
 Lys Pro Ala Glu Ala Asp Gly Arg Arg Pro Val Arg Leu Leu Trp Lys
     290                 295                 300                
 Lys Ala Arg Gly Ala Pro Val Leu Glu Lys Thr Leu Gly Tyr Asn Ile
 305                 310                 315                 320
 Trp Tyr Tyr Pro Glu Ser Asn Thr Asn Leu Thr Glu Thr Met Asn Thr
                 325                 330                 335    
 Thr Asn Gln Gln Leu Glu Leu His Leu Gly Gly Glu Ser Phe Trp Val
             340                 345                 350        
 Ser Met Ile Ser Tyr Asn Ser Leu Gly Lys Ser Pro Val Ala Thr Leu
         355                 360                 365            
 Arg Ile Pro Ala Ile Gln Glu Lys Ser Phe Gln Cys Ile Glu Val Met
     370                 375                 380                
 Gln Ala Cys Val Ala Glu Asp Gln Leu Val Val Lys Trp Gln Ser Ser
 385                 390                 395                 400
 Ala Leu Asp Val Asn Thr Trp Met Ile Glu Trp Phe Pro Asp Val Asp
                 405                 410                 415    
 Ser Glu Pro Thr Thr Leu Ser Trp Glu Ser Val Ser Gln Ala Thr Asn
             420                 425                 430        
 Trp Thr Ile Gln Gln Asp Lys Leu Lys Pro Phe Trp Cys Tyr Asn Ile
         435                 440                 445            
 Ser Val Tyr Pro Met Leu His Asp Lys Val Gly Glu Pro Tyr Ser Ile
     450                 455                 460                
 Gln Ala Tyr Ala Lys Glu Gly Val Pro Ser Glu Gly Pro Glu Thr Lys
 465                 470                 475                 480
 Val Glu Asn Ile Gly Val Lys Thr Val Thr Ile Thr Trp Lys Glu Ile
                 485                 490                 495    
 Pro Lys Ser Glu Arg Lys Gly Ile Ile Cys Asn Tyr Thr Ile Phe Tyr
             500                 505                 510        
 Gln Ala Glu Gly Gly Lys Gly Phe Ser Lys Thr Val Asn Ser Ser Ile
         515                 520                 525            
 Leu Gln Tyr Gly Leu Glu Ser Leu Lys Arg Lys Thr Ser Tyr Ile Val
     530                 535                 540                
 Gln Val Met Ala Asn Thr Ser Ala Gly Gly Thr Asn Gly Thr Ser Ile
 545                 550                 555                 560
 Asn Phe Lys Thr Leu Ser Phe Ser Val Phe Glu Ile Ile Leu Ile Thr
                 565                 570                 575    
 Ser Leu Ile Gly Gly Gly Leu Leu Ile Leu Ile Ile Leu Thr Val Ala
             580                 585                 590        
 Tyr Gly Leu Lys Lys Pro Asn Lys Leu Thr His Leu Cys Trp Pro Thr
         595                 600                 605            
 Val Pro Asn Pro Ala Glu Ser Ser Ile Ala Thr Trp His Gly Asp Asp
     610                 615                 620                
 Phe Lys Asp Lys Leu Asn Leu Lys Glu Ser Asp Asp Ser Val Asn Thr
 625                 630                 635                 640
 Glu Asp Arg Ile Leu Lys Pro Cys Ser Thr Pro Ser Asp Lys Leu Val
                 645                 650                 655    
 Ile Asp Lys Leu Val Val Asn Phe Gly Asn Val Leu Gln Glu Ile Phe
             660                 665                 670        
 Thr Asp Glu Ala Arg Thr Gly Gln Glu Asn Asn Leu Gly Gly Glu Lys
         675                 680                 685            
 Asn Gly Tyr Gln Ala Leu Thr Glu Ala Ser
     690                 695            



      <210> 505
      <211> 354
      <212> PRT
      <213> Homo sapiens


      <400> 505
 Met Met Lys Gln Cys Arg Gln Pro Leu Glu Lys Thr Gln Tyr Gly Phe
   1               5                  10                  15    
 Leu Gly Thr Asp Arg Val Glu Glu Lys Thr Ser Val Ile Thr Ile Arg
              20                  25                  30        
 Val Ser Val Thr His Arg His Asn Ser Tyr Met Glu Ala Glu Asn Leu
          35                  40                  45            
 Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly Leu Ser Asp Asp Pro Glu
      50                  55                  60                
 Leu Gln Pro Val Leu Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr
  65                  70                  75                  80
 Val Leu Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His
                  85                  90                  95    
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp
             100                 105                 110        
 Ile Cys Phe Ile Ser Thr Thr Val Pro Lys Met Leu Val Ser Ile Gln
         115                 120                 125            
 Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly Cys Leu Thr Gln Val Tyr
     130                 135                 140                
 Phe Leu Met Met Phe Ala Gly Met Asp Thr Phe Leu Leu Ala Val Met
 145                 150                 155                 160
 Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Thr Val
                 165                 170                 175    
 Ile Met Asn Pro Cys Leu Cys Gly Leu Leu Val Leu Ala Ser Trp Phe
             180                 185                 190        
 Ile Ile Phe Trp Phe Ser Leu Val His Ile Leu Leu Met Lys Arg Leu
         195                 200                 205            
 Thr Phe Ser Thr Gly Thr Glu Ile Pro His Phe Phe Cys Glu Pro Ala
     210                 215                 220                
 Gln Val Leu Lys Val Ala Cys Ser Asn Thr Leu Leu Asn Asn Ile Val
 225                 230                 235                 240
 Leu Tyr Val Ala Thr Ala Leu Leu Gly Val Phe Pro Val Ala Gly Ile
                 245                 250                 255    
 Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser Leu Met Gly Met Ser Ser
             260                 265                 270        
 Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Cys
         275                 280                 285            
 Val Val Ser Leu Phe Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser
     290                 295                 300                
 Ala Val Thr His Ser Ser Gln Ser Ser Ser Thr Ala Ser Val Met Tyr
 305                 310                 315                 320
 Ala Met Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn
                 325                 330                 335    
 Lys Asp Val Lys Gly Ala Leu Glu Arg Leu Leu Ser Arg Ala Asp Ser
             340                 345                 350        
 Cys Pro
        



      <210> 506
      <211> 1093
      <212> PRT
      <213> Homo sapiens


      <400> 506
 Met Glu Ala Leu Leu Glu Glu Gly Glu Ala Gly Tyr Pro Gly Gly Pro
   1               5                  10                  15    
 Pro Cys Gln Pro Ala Ala Gly Pro Pro Pro Ser Ser His Ser Lys Thr
              20                  25                  30        
 Gly Leu Asn Pro Pro Val Trp Ala Thr Val Gly Gly Ala Ser Ser Pro
          35                  40                  45            
 Pro Cys Pro Met Pro Ala Gly Ser Asp Arg Phe Leu Ser Trp Val Cys
      50                  55                  60                
 Phe Thr Cys Gly Ser Arg Leu Leu Leu Ser Arg Asp Val Ser Ser Ala
  65                  70                  75                  80
 Leu Gly Ser Ser Arg Ser Ser Trp Gly Ser Ala Gln Ser Ser Arg Ala
                  85                  90                  95    
 Arg Ala Met Arg Pro Thr Asp Leu Val Pro Glu Arg Ser Ser Arg Glu
             100                 105                 110        
 Ala Pro Ala Pro Ser Arg Arg Gly Thr Cys Phe Leu Pro Ser Leu Pro
         115                 120                 125            
 Pro Gln His Ser Gln Thr Ser Pro Trp Ala Glu Pro Ala Ser Ser Arg
     130                 135                 140                
 Arg Cys Leu Gly Cys Arg Pro Arg Lys Phe Glu Met Ala Asp Gly Ser
 145                 150                 155                 160
 Leu Thr Gly Gly Gly Leu Glu Ala Ala Ala Met Ala Pro Glu Arg Thr
                 165                 170                 175    
 Gly Trp Ala Val Glu Gln Glu Leu Ala Ser Leu Glu Lys Gly Leu Phe
             180                 185                 190        
 Gln Asp Glu Asp Ser Cys Ser Asp Cys Ser Tyr Arg Asp Lys Pro Gly
         195                 200                 205            
 Ser Ser Leu Gln Ser Phe Met Pro Glu Gly Lys Thr Phe Phe Pro Glu
     210                 215                 220                
 Ile Phe Gln Thr Asn Gln Leu Leu Phe Tyr Glu Arg Phe Arg Ala Tyr
 225                 230                 235                 240
 Gln Asp Tyr Ile Leu Ala Asp Cys Lys Ala Ser Glu Val Gln Glu Phe
                 245                 250                 255    
 Thr Ala Glu Phe Leu Glu Lys Val Leu Glu Pro Ser Gly Trp Arg Ala
             260                 265                 270        
 Val Trp His Thr Asn Val Phe Lys Val Leu Val Glu Ile Thr Asp Val
         275                 280                 285            
 Asp Phe Ala Ala Leu Lys Ala Val Val Arg Leu Ala Glu Pro Tyr Leu
     290                 295                 300                
 Cys Asp Ser Gln Val Ser Thr Phe Thr Met Glu Cys Met Lys Glu Leu
 305                 310                 315                 320
 Leu Asp Leu Lys Glu His Arg Leu Pro Leu Gln Glu Leu Trp Val Val
                 325                 330                 335    
 Phe Asp Asp Ser Gly Val Phe Asp Gln Thr Ala Leu Ala Ile Glu His
             340                 345                 350        
 Val Arg Phe Phe Tyr Gln Asn Ile Trp Arg Ser Trp Asp Glu Glu Glu
         355                 360                 365            
 Glu Asp Glu Tyr Asp Tyr Phe Val Arg Cys Val Glu Pro Arg Leu Arg
     370                 375                 380                
 Leu Tyr Val Phe Gly Tyr Gln Lys Asn Ser Asn Ile Gln Ala Lys Gly
 385                 390                 395                 400
 Val Arg Ser Ser Gly Gln Lys Ile Thr His Val Val Ser Ser Thr Met
                 405                 410                 415    
 Met Ala Gly Leu Leu Arg Ser Leu Leu Thr Asp Arg Leu Cys Gln Glu
             420                 425                 430        
 Pro Gly Glu Glu Glu Arg Glu Ile Gln Phe His Ser Asp Pro Leu Ser
         435                 440                 445            
 Ala Ile Asn Ala Cys Phe Glu Gly Asp Thr Val Ile Val Cys Pro Gly
     450                 455                 460                
 His Tyr Val Val His Gly Thr Phe Ser Ile Ala Asp Ser Ile Glu Leu
 465                 470                 475                 480
 Glu Gly Leu Phe Gln Asp Glu Asp Ser Cys Ser Asp Cys Ser Tyr Arg
                 485                 490                 495    
 Asp Lys Pro Gly Ser Ser Leu Gln Ser Phe Met Pro Glu Gly Lys Thr
             500                 505                 510        
 Phe Phe Pro Glu Ile Phe Gln Thr Asn Gln Leu Leu Phe Tyr Glu Arg
         515                 520                 525            
 Phe Arg Ala Tyr Gln Asp Tyr Ile Leu Ala Trp Leu Arg Ala Asp Phe
     530                 535                 540                
 Leu Ala His Leu Ser Arg Thr Arg Ser Pro Pro Leu Leu Val Ile Leu
 545                 550                 555                 560
 Cys His Leu Leu Val Ile Ile Val Phe Val Asp Leu Pro Asp Tyr Ser
                 565                 570                 575    
 Val Ser Ser Met Arg Ile Thr Asp Val Asp Phe Ala Ala Leu Lys Ala
             580                 585                 590        
 Val Val Arg Leu Ala Glu Pro Tyr Leu Cys Asp Ser Gln Val Ser Thr
         595                 600                 605            
 Phe Thr Met Glu Cys Met Lys Glu Leu Leu Asp Leu Lys Glu His Arg
     610                 615                 620                
 Leu Pro Leu Gln Glu Leu Trp Val Val Phe Asp Asp Ser Gly Val Phe
 625                 630                 635                 640
 Asp Gln Thr Ala Leu Ala Ile Glu His Val Arg His Tyr Asp Ile Leu
                 645                 650                 655    
 Glu Asp Arg Val Pro Ser Gly Leu Ile Val Asp Tyr His Asn Leu Leu
             660                 665                 670        
 Ser Gln Cys Glu Glu Ser Tyr Arg Lys Phe Leu Asn Leu Arg Ser Ser
         675                 680                 685            
 Leu Ser Asn Cys Asn Ser Asp Ser Glu Gln Glu Asn Ile Ser Met Val
     690                 695                 700                
 Glu Gly Leu Lys Leu Tyr Ser Glu Met Glu Gln Leu Lys Gln Lys Leu
 705                 710                 715                 720
 Lys Leu Ile Glu Asn Pro Leu Leu Arg Tyr Val Phe Gly Tyr Gln Lys
                 725                 730                 735    
 Asn Ser Asn Ile Gln Ala Lys Gly Val Arg Ser Ser Gly Gln Lys Ile
             740                 745                 750        
 Thr His Val Val Ser Ser Thr Met Met Ala Gly Leu Leu Arg Ser Leu
         755                 760                 765            
 Leu Thr Asp Arg Leu Cys Gln Glu Pro Gly Glu Glu Glu Arg Glu Ile
     770                 775                 780                
 Gln Phe His Ser Asp Pro Leu Ser Ala Ile Asn Ala Cys Phe Glu Gly
 785                 790                 795                 800
 Asp Thr Val Ile Val Cys Pro Gly His Tyr Val Val His Gly Thr Phe
                 805                 810                 815    
 Ser Ile Ala Asp Ser Ile Glu Leu Glu Gly Tyr Gly Leu Pro Asp Asp
             820                 825                 830        
 Ile Val Ile Glu Lys Arg Gly Lys Gly Asp Thr Phe Val Asp Cys Thr
         835                 840                 845            
 Gly Ala Asp Ile Lys Ile Ser Gly Ile Lys Phe Val Gln His Asp Ala
     850                 855                 860                
 Val Glu Gly Ile Leu Ile Val His Arg Gly Lys Thr Thr Leu Glu Asn
 865                 870                 875                 880
 Cys Val Leu Gln Cys Glu Thr Thr Gly Val Thr Val Arg Thr Ser Ala
                 885                 890                 895    
 Glu Phe Leu Met Lys Asn Ser Asp Leu Tyr Gly Ala Lys Gly Ala Gly
             900                 905                 910        
 Ile Glu Ile Tyr Pro Gly Ser Gln Cys Thr Leu Ser Asp Asn Gly Ile
         915                 920                 925            
 His His Cys Lys Glu Gly Ile Leu Ile Lys Asp Phe Leu Asp Glu His
     930                 935                 940                
 Tyr Asp Ile Pro Lys Ile Ser Met Val Asn Asn Ile Ile His Asn Asn
 945                 950                 955                 960
 Glu Gly Tyr Gly Val Val Leu Val Lys Pro Thr Ile Phe Ser Asp Leu
                 965                 970                 975    
 Gln Glu Asn Ala Glu Asp Gly Thr Glu Glu Asn Lys Ala Leu Lys Ile
             980                 985                 990        
 Gln Thr Ser Gly Glu Pro Asp Val Ala Glu Arg Val Asp Leu Glu Glu
         995                1000                1005            
 Leu Ile Glu Cys Ala Thr Gly Lys Met Glu Leu Cys Ala Arg Thr Asp
    1010                1015                1020                
 Pro Ser Glu Gln Val Glu Gly Asn Cys Glu Ile Val Asn Glu Leu Ile
1025                1030                1035                1040
 Ala Ala Ser Thr Gln Lys Gly Gln Ile Lys Lys Lys Arg Leu Ser Glu
                1045                1050                1055    
 Leu Gly Ile Thr Gln Ala Asp Asp Asn Leu Met Ser Gln Glu Met Phe
            1060                1065                1070        
 Val Gly Ile Val Gly Asn Gln Phe Lys Trp Asn Gly Lys Gly Ser Phe
        1075                1080                1085            
 Gly Thr Phe Leu Phe
    1090            



      <210> 507
      <211> 568
      <212> PRT
      <213> Homo sapiens


      <400> 507
 Met Ser Leu Met Leu Asp Asp Gln Pro Pro Met Glu Ala Gln Tyr Ala
   1               5                  10                  15    
 Glu Glu Gly Pro Gly Pro Gly Ile Phe Arg Ala Glu Pro Gly Asp Gln
              20                  25                  30        
 Gln His Pro Ile Ser Gln Ala Val Cys Trp Arg Ser Met Arg Arg Gly
          35                  40                  45            
 Cys Ala Val Leu Gly Ala Leu Gly Leu Leu Ala Gly Ala Gly Val Gly
      50                  55                  60                
 Ser Trp Leu Leu Val Leu Tyr Leu Cys Pro Ala Ala Ser Gln Pro Ile
  65                  70                  75                  80
 Ser Gly Thr Leu Gln Asp Glu Glu Ile Thr Leu Ser Cys Ser Glu Ala
                  85                  90                  95    
 Ser Ala Glu Glu Ala Leu Leu Pro Ala Leu Pro Lys Thr Val Ser Phe
             100                 105                 110        
 Arg Ile Asn Ser Glu Asp Phe Leu Leu Glu Ala Gln Val Arg Asp Gln
         115                 120                 125            
 Pro Arg Trp Leu Leu Val Cys His Glu Gly Trp Ser Pro Ala Leu Gly
     130                 135                 140                
 Leu Gln Ile Cys Trp Ser Leu Gly His Leu Arg Leu Thr His His Lys
 145                 150                 155                 160
 Gly Val Asn Leu Thr Asp Ile Lys Leu Asn Ser Ser Gln Glu Phe Ala
                 165                 170                 175    
 Gln Leu Ser Pro Arg Leu Gly Gly Phe Leu Glu Glu Ala Trp Gln Pro
             180                 185                 190        
 Arg Asn Asn Cys Thr Ser Gly Gln Val Val Ser Leu Arg Cys Ser Glu
         195                 200                 205            
 Cys Gly Ala Arg Pro Leu Ala Ser Arg Ile Val Gly Gly Gln Ser Val
     210                 215                 220                
 Ala Pro Gly Arg Trp Pro Trp Gln Ala Ser Val Ala Leu Gly Phe Arg
 225                 230                 235                 240
 His Thr Cys Gly Gly Ser Val Leu Ala Pro Arg Trp Val Val Thr Ala
                 245                 250                 255    
 Ala His Cys Met His Arg Gln Val Ser Val Ala Ala Glu Asp Arg Glu
             260                 265                 270        
 Pro Gln Leu Pro Phe Leu Phe Gly Cys Trp Tyr Val Leu Tyr Gln Met
         275                 280                 285            
 Phe Val Ser Asn Cys Leu Gln Leu Phe Ala Pro Lys Gly Pro Ala Ala
     290                 295                 300                
 Phe Ile Lys His Leu Leu His Ala Gln Cys Leu Ala Gly Cys Trp Gly
 305                 310                 315                 320
 Asp Thr Lys Arg His Ser Leu Trp Gly Leu Gly Ala His Arg Leu Leu
                 325                 330                 335    
 Thr Ala Pro Pro Pro Met Ala Ala Leu Ala Ser Phe Leu His Leu Leu
             340                 345                 350        
 Pro Cys Leu Gly Thr Pro Leu Leu Pro Leu Pro Ser Pro Leu Ser Met
         355                 360                 365            
 Ala Pro Val Cys Ser Phe Arg Leu Ala Arg Leu Ser Ser Trp Arg Val
     370                 375                 380                
 His Ala Gly Leu Val Ser His Ser Ala Val Arg Pro His Gln Gly Ala
 385                 390                 395                 400
 Leu Val Glu Arg Ile Ile Pro His Pro Leu Tyr Ser Ala Gln Asn His
                 405                 410                 415    
 Asp Tyr Asp Val Ala Leu Leu Arg Leu Gln Thr Ala Leu Asn Phe Ser
             420                 425                 430        
 Asp Thr Val Gly Ala Val Cys Leu Pro Ala Lys Glu Gln His Phe Pro
         435                 440                 445            
 Lys Gly Ser Arg Cys Trp Val Ser Gly Trp Gly His Thr His Pro Ser
     450                 455                 460                
 His Thr Tyr Ser Ser Asp Met Leu Gln Asp Thr Val Val Pro Leu Phe
 465                 470                 475                 480
 Ser Thr Gln Leu Cys Asn Ser Ser Cys Val Tyr Ser Gly Ala Leu Thr
                 485                 490                 495    
 Pro Arg Met Leu Cys Ala Gly Tyr Leu Asp Gly Arg Ala Asp Ala Cys
             500                 505                 510        
 Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Pro Asp Gly Asp Thr Trp
         515                 520                 525            
 Arg Leu Val Gly Val Val Ser Trp Gly Arg Ala Cys Ala Glu Pro Asn
     530                 535                 540                
 His Pro Gly Val Tyr Ala Lys Val Ala Glu Phe Leu Asp Trp Ile His
 545                 550                 555                 560
 Asp Thr Ala Gln Asp Ser Leu Leu
                 565            



      <210> 508
      <211> 1063
      <212> PRT
      <213> Homo sapiens


      <400> 508
 Met Glu Glu Leu Arg Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp
   1               5                  10                  15    
 Ser Ala His Asn Gln Ala Met Val His Trp Ser Gly His Asn Ser Ser
              20                  25                  30        
 Val Ile Leu Ile Leu Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile
          35                  40                  45            
 Thr Glu Ser Ser Leu Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu
      50                  55                  60                
 Lys Leu Asn Asp Lys Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr
  65                  70                  75                  80
 Val Cys Pro Thr Asn Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu
                  85                  90                  95    
 Ile Glu Ser Ser Leu Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln
             100                 105                 110        
 Lys Tyr Arg Leu Asn Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys
         115                 120                 125            
 Gln Glu Asp Trp Ile Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser
     130                 135                 140                
 Ser Ala Glu Phe Gly Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val
 145                 150                 155                 160
 Pro Asn Arg Phe Tyr Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp
                 165                 170                 175    
 Leu Val His Leu Glu Ala Arg Thr Val Asp Gly His Ser His Tyr Leu
             180                 185                 190        
 Thr Cys Arg Met Gln Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe
         195                 200                 205            
 Pro Gly Tyr Ile Asp Pro Asp Ser Leu Ile Val Gln Asp His Tyr Val
     210                 215                 220                
 Phe Val Gln Leu Thr Ser Gly Gly Arg Pro His Tyr Tyr Val Ser Tyr
 225                 230                 235                 240
 Arg Arg Asn Ala Phe Ala Gln Met Lys Leu Pro Lys Tyr Ala Leu Pro
                 245                 250                 255    
 Lys Asp Met His Val Ile Ser Thr Asp Glu Asn Gln Val Phe Ala Ala
             260                 265                 270        
 Val Gln Glu Trp Asn Gln Asn Asp Thr Tyr Asn Leu Tyr Ile Ser Asp
         275                 280                 285            
 Thr Arg Gly Val Tyr Phe Thr Leu Ala Leu Glu Asn Val Gln Ser Ser
     290                 295                 300                
 Arg Gly Pro Glu Gly Asn Ile Met Ile Asp Leu Tyr Glu Val Ala Gly
 305                 310                 315                 320
 Ile Lys Gly Met Phe Leu Ala Asn Lys Lys Ile Asp Asn Gln Val Lys
                 325                 330                 335    
 Thr Phe Ile Thr Tyr Asn Lys Gly Arg Asp Trp Arg Leu Leu Gln Ala
             340                 345                 350        
 Pro Asp Thr Asp Leu Arg Gly Asp Pro Val His Cys Leu Leu Pro Tyr
         355                 360                 365            
 Cys Ser Leu His Leu His Leu Lys Val Ser Glu Asn Pro Tyr Thr Ser
     370                 375                 380                
 Gly Ile Ile Ala Ser Lys Asp Thr Ala Pro Ser Ile Ile Val Ala Ser
 385                 390                 395                 400
 Gly Asn Ile Gly Ser Glu Leu Ser Asp Thr Asp Ile Ser Met Phe Val
                 405                 410                 415    
 Ser Ser Asp Ala Gly Asn Thr Trp Arg Gln Ile Phe Glu Glu Glu His
             420                 425                 430        
 Ser Val Leu Tyr Leu Asp Gln Gly Gly Val Leu Val Ala Met Lys His
         435                 440                 445            
 Thr Ser Leu Pro Ile Arg His Leu Trp Leu Ser Phe Asp Glu Gly Arg
     450                 455                 460                
 Ser Trp Ser Lys Tyr Ser Phe Thr Ser Ile Pro Leu Phe Val Asp Gly
 465                 470                 475                 480
 Val Leu Gly Glu Pro Gly Glu Glu Thr Leu Ile Met Thr Val Phe Gly
                 485                 490                 495    
 His Phe Ser His Arg Ser Glu Trp Gln Leu Val Lys Val Asp Tyr Lys
             500                 505                 510        
 Ser Ile Phe Asp Arg Arg Cys Ala Glu Glu Asp Tyr Arg Pro Trp Gln
         515                 520                 525            
 Leu His Ser Gln Gly Glu Ala Cys Ile Met Gly Ala Lys Arg Ile Tyr
     530                 535                 540                
 Lys Lys Arg Lys Ser Glu Arg Lys Cys Met Gln Gly Lys Tyr Ala Gly
 545                 550                 555                 560
 Ala Met Glu Ser Glu Pro Cys Val Cys Thr Glu Ala Asp Phe Asp Cys
                 565                 570                 575    
 Asp Tyr Gly Tyr Glu Arg His Ser Asn Gly Gln Cys Leu Pro Ala Phe
             580                 585                 590        
 Trp Phe Asn Pro Ser Ser Leu Ser Lys Asp Cys Ser Leu Gly Gln Ser
         595                 600                 605            
 Tyr Leu Asn Ser Thr Gly Tyr Arg Lys Val Val Ser Asn Asn Cys Thr
     610                 615                 620                
 Asp Gly Val Arg Glu Gln Tyr Thr Ala Lys Pro Gln Lys Cys Pro Gly
 625                 630                 635                 640
 Lys Ala Pro Arg Gly Leu Arg Ile Val Thr Ala Asp Gly Lys Leu Thr
                 645                 650                 655    
 Ala Glu Gln Gly His Asn Val Thr Leu Met Val Gln Leu Glu Glu Gly
             660                 665                 670        
 Asp Val Gln Arg Thr Leu Ile Gln Val Asp Phe Gly Asp Gly Ile Ala
         675                 680                 685            
 Val Ser Tyr Val Asn Leu Ser Ser Met Glu Asp Gly Ile Lys His Val
     690                 695                 700                
 Tyr Gln Asn Val Gly Ile Phe Arg Val Thr Val Gln Val Asp Asn Ser
 705                 710                 715                 720
 Leu Gly Ser Asp Ser Ala Val Leu Tyr Leu His Val Thr Cys Pro Leu
                 725                 730                 735    
 Glu His Val His Leu Ser Leu Pro Phe Val Thr Thr Lys Asn Lys Glu
             740                 745                 750        
 Val Asn Ala Thr Ala Val Leu Trp Pro Ser Gln Val Gly Thr Leu Thr
         755                 760                 765            
 Tyr Val Trp Trp Tyr Gly Asn Asn Thr Glu Pro Leu Ile Thr Leu Glu
     770                 775                 780                
 Gly Ser Ile Ser Phe Arg Phe Thr Ser Glu Gly Met Asn Thr Ile Thr
 785                 790                 795                 800
 Val Gln Val Ser Ala Gly Asn Ala Ile Leu Gln Asp Thr Lys Thr Ile
                 805                 810                 815    
 Ala Val Tyr Glu Glu Phe Arg Ser Leu Arg Leu Ser Phe Ser Pro Asn
             820                 825                 830        
 Leu Asp Asp Tyr Asn Pro Asp Ile Pro Glu Trp Arg Arg Asp Ile Gly
         835                 840                 845            
 Arg Val Ile Lys Lys Ser Leu Val Glu Ala Thr Gly Val Pro Gly Gln
     850                 855                 860                
 His Ile Leu Val Ala Val Leu Pro Gly Leu Pro Thr Thr Ala Glu Leu
 865                 870                 875                 880
 Phe Val Leu Pro Tyr Gln Asp Pro Ala Gly Glu Asn Lys Arg Ser Thr
                 885                 890                 895    
 Asp Asp Leu Glu Gln Ile Ser Glu Leu Leu Ile His Thr Leu Asn Gln
             900                 905                 910        
 Asn Ser Val His Phe Glu Leu Lys Pro Gly Val Arg Val Leu Val His
         915                 920                 925            
 Ala Ala His Leu Thr Ala Ala Pro Leu Val Asp Leu Thr Pro Thr His
     930                 935                 940                
 Ser Gly Ser Ala Met Leu Met Leu Leu Ser Val Val Phe Val Gly Leu
 945                 950                 955                 960
 Ala Val Phe Val Ile Tyr Lys Phe Lys Arg Lys Ile Pro Gly Ile Asn
                 965                 970                 975    
 Val Tyr Ala Gln Met Gln Asn Glu Lys Glu Gln Glu Met Ile Ser Pro
             980                 985                 990        
 Val Ser His Ser Glu Ser Arg Pro Asn Val Pro Gln Thr Glu Leu Arg
         995                1000                1005            
 Arg Pro Gly Gln Leu Ile Asp Glu Lys Val Glu Ser Gln Leu Ile Asp
    1010                1015                1020                
 Cys Pro Leu Pro Glu Val Val Lys Trp Thr Phe Ser Tyr Phe Asn Gly
1025                1030                1035                1040
 Ser Leu Ser Ala Cys Glu Val Gly Met Gly Ile Gln Gln Arg Gly Ile
                1045                1050                1055    
 Glu Asn Leu Thr Phe Thr Cys
            1060            



      <210> 509
      <211> 338
      <212> PRT
      <213> Homo sapiens


      <400> 509
 Met Val Trp Gly Arg Arg Lys Ser Gln Asp Cys Asp Pro Thr Met Ile
   1               5                  10                  15    
 Thr Ala Phe Trp Ile Gly Leu His Leu Leu Glu Gly Pro Gln Gly Pro
              20                  25                  30        
 Val Leu Ala Ala Asn Leu Thr Ile Leu Ser Ser Lys Arg Lys Val Thr
          35                  40                  45            
 Phe Lys Lys Gln Ser Arg Arg Gly Pro Arg Pro Thr Phe Lys Ile Leu
      50                  55                  60                
 Ser Lys Ser Arg Gln Glu Asp Arg Pro Ala Leu Ser Arg Leu Val Gly
  65                  70                  75                  80
 Ser Arg Arg Arg Leu Ile Ala Ala Gly Ala Leu Gly Val Val Met Val
                  85                  90                  95    
 Leu Leu Leu Val Ile Leu Ile Pro Val Leu Met Leu Gly Thr Cys Arg
             100                 105                 110        
 Met Val Cys Asp Pro Tyr Gly Gly Thr Lys Ala Pro Ser Thr Ala Ala
         115                 120                 125            
 Thr Pro Asp Arg Gly Leu Met Gln Ser Leu Pro Thr Phe Ile Gln Gly
     130                 135                 140                
 Pro Lys Gly Glu Ala Gly Arg Pro Gly Lys Ala Gly Pro Arg Gly Pro
 145                 150                 155                 160
 Pro Gly Glu Pro Gly Pro Pro Gly Pro Met Gly Pro Pro Gly Glu Lys
                 165                 170                 175    
 Gly Glu Pro Gly Arg Gln Gly Leu Pro Gly Pro Pro Gly Ala Pro Gly
             180                 185                 190        
 Leu Asn Ala Ala Gly Ala Ile Ser Ala Ala Thr Tyr Ser Thr Gly Pro
         195                 200                 205            
 Lys Ile Ala Phe Tyr Ala Gly Leu Lys Arg Gln His Glu Gly Tyr Glu
     210                 215                 220                
 Val Leu Lys Phe Asp Asp Val Val Thr Asn Leu Gly Asn His Tyr Asp
 225                 230                 235                 240
 Pro Thr Thr Gly Lys Phe Thr Cys Ser Ile Pro Gly Ile Tyr Phe Phe
                 245                 250                 255    
 Thr Tyr His Val Leu Met Arg Gly Gly Asp Gly Thr Ser Met Trp Ala
             260                 265                 270        
 Asp Leu Cys Lys Asn Asn Gln Val Arg Ala Ser Ala Ile Ala Gln Asp
         275                 280                 285            
 Ala Asp Gln Asn Tyr Asp Tyr Ala Ser Asn Ser Val Val Leu His Leu
     290                 295                 300                
 Glu Pro Gly Asp Glu Val Tyr Ile Lys Leu Asp Gly Gly Lys Ala His
 305                 310                 315                 320
 Gly Gly Asn Asn Asn Lys Tyr Ser Thr Phe Ser Gly Phe Ile Ile Tyr
                 325                 330                 335    
 Ala Asp
        



      <210> 510
      <211> 141
      <212> PRT
      <213> Homo sapiens


      <400> 510
 Met Glu Pro Ser His Lys Asp Ala Glu Thr Ala Ala Ala Ala Ala Ala
   1               5                  10                  15    
 Val Ala Ala Ala Asp Pro Arg Gly Ala Ser Ser Ser Ser Gly Val Val
              20                  25                  30        
 Val Gln Val Arg Glu Lys Lys Gly Pro Leu Arg Ala Ala Ile Pro Tyr
          35                  40                  45            
 Met Pro Phe Pro Val Ala Val Ile Cys Leu Phe Leu Asn Thr Phe Val
      50                  55                  60                
 Pro Gly Leu Gly Thr Phe Val Ser Ala Phe Thr Val Leu Cys Gly Ala
  65                  70                  75                  80
 Arg Thr Asp Leu Pro Asp Arg His Val Cys Cys Val Phe Trp Leu Asn
                  85                  90                  95    
 Ile Ala Ala Ala Leu Ile Gln Ile Leu Thr Ala Ile Val Met Val Gly
             100                 105                 110        
 Trp Ile Met Ser Ile Phe Trp Gly Met Asp Met Val Ile Leu Ala Ile
         115                 120                 125            
 Ser Gln Gly Tyr Lys Glu Gln Gly Ile Pro Gln Gln Leu
     130                 135                 140    



      <210> 511
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 511
 Met Asp Ser Pro Ser Leu Arg Glu Leu Gln Gln Pro Leu Leu Glu Gly
   1               5                  10                  15    
 Thr Glu Cys Glu Thr Pro Ala Gln Lys Pro Gly Arg His Glu Leu Gly
              20                  25                  30        
 Ser Pro Leu Arg Glu Ile Ala Phe Ala Glu Ser Leu Arg Gly Leu Gln
          35                  40                  45            
 Phe Leu Ser Pro Pro Leu Pro Ser Val Ser Ala Gly Leu Gly Glu Pro
      50                  55                  60                
 Arg Pro Pro Asp Val Glu Asp Met Ser Ser Ser Asp Ser Asp Ser Asp
  65                  70                  75                  80
 Trp Asp Gly Gly Ser Arg Leu Ser Pro Phe Leu Pro His Asp His Leu
                  85                  90                  95    
 Gly Leu Ala Val Phe Ser Met Leu Cys Cys Phe Trp Pro Val Gly Ile
             100                 105                 110        
 Ala Ala Phe Cys Leu Ala Gln Lys Thr Arg Pro Ser Cys Pro Tyr Ser
         115                 120                 125            
 Pro His Cys Glu Pro
     130            



      <210> 512
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 512
 Met Ala Gly Asp Thr Glu Val Trp Lys Gln Met Phe Gln Glu Leu Met
   1               5                  10                  15    
 Arg Glu Val Lys Pro Trp His Arg Trp Thr Leu Arg Pro Asp Lys Gly
              20                  25                  30        
 Leu Leu Pro Asn Val Leu Lys Pro Gly Trp Met Gln Tyr Gln Gln Trp
          35                  40                  45            
 Thr Phe Ala Arg Phe Gln Cys Ser Ser Cys Ser Arg Asn Trp Ala Ser
      50                  55                  60                
 Ala Gln Val Leu Val Leu Phe His Met Asn Trp Ser Glu Glu Lys Ser
  65                  70                  75                  80
 Arg Gly Gln Val Lys Met Arg Val Phe Thr Gln Arg Cys Lys Lys Cys
                  85                  90                  95    
 Pro Gln Pro Leu Phe Glu Asp Pro Glu Phe Thr Gln Glu Asn Ile Ser
             100                 105                 110        
 Arg Ile Leu Lys Asn Leu Val Phe Arg Ile Leu Lys Lys Cys Tyr Arg
         115                 120                 125            
 Gly Arg Phe Gln Leu Ile Glu Glu Val Pro Met Ile Lys Asp Ile Ser
     130                 135                 140                
 Leu Glu Gly Pro His Asn Ser Asp Asn Cys Glu Ala Cys Leu Gln Gly
 145                 150                 155                 160
 Phe Cys Ala Gly Pro Ile Gln Val Thr Ser Leu Pro Pro Ser Gln Thr
                 165                 170                 175    
 Pro Arg Val His Ser Ile Tyr Lys Val Glu Glu Val Val Lys Pro Trp
             180                 185                 190        
 Ala Ser Gly Glu Asn Val Tyr Ser Tyr Ala Cys Gln Asn His Ile Cys
         195                 200                 205            
 Arg Asn Leu Ser Ile Phe Cys Cys Cys Val Ile Leu Ile Val Ile Val
     210                 215                 220                
 Val Ile Val Val Lys Thr Ala Ile
 225                 230        



      <210> 513
      <211> 834
      <212> PRT
      <213> Homo sapiens


      <400> 513
 Met Ile Ile Phe Asn Leu Ser Ser Tyr Asn Pro Gly Pro Phe Ile Leu
   1               5                  10                  15    
 Val Gly Ile Pro Gly Leu Glu Gln Phe His Val Trp Ile Gly Ile Pro
              20                  25                  30        
 Phe Cys Ile Ile Tyr Ile Val Ala Ile Val Gly Asn Cys Ile Leu Leu
          35                  40                  45            
 Tyr Leu Ile Val Val Glu His Ser Leu His Glu Pro Met Phe Phe Phe
      50                  55                  60                
 Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser Thr Ala Gly Val
  65                  70                  75                  80
 Pro Lys Ala Leu Ser Ile Phe Trp Leu Gly Ala Arg Glu Ile Thr Phe
                  85                  90                  95    
 Pro Gly Cys Leu Thr Gln Met Phe Phe Leu His Tyr Asn Phe Val Leu
             100                 105                 110        
 Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp His Tyr Val Ala Ile
         115                 120                 125            
 Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Lys Thr Ile Ile
     130                 135                 140                
 Lys Ser Ala Met Gly Ile Ser Phe Arg Ser Phe Cys Ile Ile Leu Pro
 145                 150                 155                 160
 Asp Val Phe Leu Leu Thr Cys Leu Pro Phe Cys Arg Thr Arg Ile Ile
                 165                 170                 175    
 Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Gln Leu Ala Cys Ala
             180                 185                 190        
 Asp Ile Ser Ile Asn Phe Trp Tyr Gly Phe Cys Val Pro Ile Met Thr
         195                 200                 205            
 Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Ala His Ile Leu
     210                 215                 220                
 Cys Ala Val Phe Gly Leu Pro Ser Gln Asp Ala Cys Gln Lys Ala Leu
 225                 230                 235                 240
 Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met Phe Tyr Thr Pro
                 245                 250                 255    
 Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His Asn Val Ser Arg
             260                 265                 270        
 Thr Phe His Ile Met Phe Ala Asn Leu Tyr Ile Val Ile Pro Pro Ala
         275                 280                 285            
 Leu Asn Pro Met Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Lys
     290                 295                 300                
 Leu Asn Gly Asp Val Glu Ala Val Gly Thr Glu Ala Gly Leu Asp Gly
 305                 310                 315                 320
 Trp Arg Arg Asp Ala His Ser Ser Phe Leu Ile Ser Pro Pro Thr Ala
                 325                 330                 335    
 Glu Arg Asp Thr Ala Arg Trp Arg Gln Glu Met Gly Leu Asp Pro Ala
             340                 345                 350        
 Leu Pro Ala Phe Ser Gln Asn Leu Leu Ile Ser Gly Ser Gly Ser Phe
         355                 360                 365            
 Val Leu Leu Gly Met Pro Gly Leu Glu Ala Leu His Ala Trp Leu Ser
     370                 375                 380                
 Val Pro Val Cys Leu Leu Tyr Met Ala Ala Leu Val Gly Asn Ala Leu
 385                 390                 395                 400
 Leu Val Gly Leu Val Val Ala Asp Lys Ala Leu Trp Ala Pro Met Tyr
                 405                 410                 415    
 Gln Leu Leu Trp Leu Leu Ala Ala Ala Asp Phe Val Leu Ala Thr Ser
             420                 425                 430        
 Thr Val Pro Lys Ala Leu Ala Val Leu Trp Gly Leu Ser Met Leu Leu
         435                 440                 445            
 Ser Thr Ala Val Asp Cys Gln Pro Leu Arg Tyr Gly Ala Leu Leu Ala
     450                 455                 460                
 Gln Phe Val Lys Leu Pro Tyr Cys Gly Gln Trp Ala Leu Pro His Thr
 465                 470                 475                 480
 Tyr Cys Glu His Met Gly Val Ala Cys Leu Ala Cys Gly Asp Thr Cys
                 485                 490                 495    
 Pro Ile Ile Arg Tyr Gly Leu Ala Thr Thr Leu Leu Ser Pro Ala Leu
             500                 505                 510        
 Asp Leu Gly Leu Ile Gly Ala Ser Tyr Ala Leu Ile Phe Arg Ala Val
         515                 520                 525            
 Cys Arg Leu Pro Ser His Val Ala Cys His Lys Ala Leu Gly Asn Cys
     530                 535                 540                
 Gly Thr Tyr Ala Ser Ile Ile Gly Leu Phe Tyr Thr Pro Ala Leu Phe
 545                 550                 555                 560
 Ser Phe Leu Ala His Cys Phe Gly Cys His Thr Val Pro Asn His Ile
                 565                 570                 575    
 His Ile Leu Leu Ala Asn Leu Tyr Ala Val Val Phe Pro Ala Phe Asn
             580                 585                 590        
 Pro Val Val Tyr Gly Val Gln Thr Gln Gln Ser Ser Glu Ala Gln Glu
         595                 600                 605            
 Leu Ala Ser Thr Phe Leu Gly Arg Ser Ser Glu Glu Gly Ile Thr Ala
     610                 615                 620                
 Val Gln Arg Pro Glu Asp Leu Arg Leu His Ser Ile Met Trp Gln Gly
 625                 630                 635                 640
 Leu Glu Glu Lys Ser Ala Ser Ser Asn Val Asn Cys Ser Gln Ile Gln
                 645                 650                 655    
 Pro Val His Glu Val Gly Pro Gly Cys Ser Asn Met Leu His Tyr Val
             660                 665                 670        
 Tyr Cys Ala Cys Gly His Gly Leu Gln Leu Val Arg Ser Val Ser Ser
         675                 680                 685            
 Ser Val Asp Glu Gly Gly Thr Cys His Cys Met Val His Leu Pro Asn
     690                 695                 700                
 Asn Pro Ile Pro Leu Glu Gln Leu Glu Gln Leu Gln Ser Thr Ala Gln
 705                 710                 715                 720
 Glu Leu Ile Cys Lys Tyr Glu Gln Lys Leu Ser Arg Gln Leu Pro Val
                 725                 730                 735    
 His Pro Leu His Ala Asp Val Ser Glu Cys Ala Arg Ala Ile Glu Asp
             740                 745                 750        
 Lys Asp Asn Glu Val Leu Glu Met Ser His Met Leu Lys Ser Trp Asn
         755                 760                 765            
 Pro Ser Ala Leu Ala Ser Pro Tyr Glu Asn Pro Gly Phe Asn Leu Leu
     770                 775                 780                
 Cys Leu Glu Leu Glu Gly Ala Gln Glu Leu Val Thr Gln Leu Lys Ala
 785                 790                 795                 800
 Met Gly Gly Val Ser Val Ala Gly Asp Leu Leu His Gln Leu Gln Ser
                 805                 810                 815    
 Gln Asn Thr Pro Ser Ala Gln Leu Thr Leu Lys Ala Ala Thr Val Ala
             820                 825                 830        
 Val Ser
        



      <210> 514
      <211> 678
      <212> PRT
      <213> Homo sapiens


      <400> 514
 Met Thr Arg Gly Val Leu Ser Arg Thr Ser Ser Ile Gln Pro Ser Phe
   1               5                  10                  15    
 Arg His Arg Ser Asp Asp Pro Val Gly Ser Leu Trp Gly Glu Asn Asp
              20                  25                  30        
 Tyr Pro Glu Gly Ile Glu Met Ala Ser Met Glu Met Ala Asn Ser Tyr
          35                  40                  45            
 Gly His Ser Leu Pro Gly Ala Pro Gly Ser Gly Tyr Val Asn Pro Ala
      50                  55                  60                
 Tyr Val Gly Glu Ser Gly Pro Val His Ala Tyr Gly Asn Pro Pro Leu
  65                  70                  75                  80
 Ser Glu Cys Asp Trp His Lys Ser Pro Gln Gly Gln Lys Leu Ile Ala
                  85                  90                  95    
 Ser Leu Ile Pro Met Thr Ser Arg Asp Arg Ile Lys Ala Ile Arg Asn
             100                 105                 110        
 Gln Pro Arg Thr Met Glu Glu Lys Arg Lys Leu Arg Lys Ile Val Asp
         115                 120                 125            
 Lys Glu Lys Ser Lys Gln Thr His Arg Ile Leu Gln Leu Asn Cys Cys
     130                 135                 140                
 Ile Gln Cys Leu Asn Ser Ile Ser Arg Ala Tyr Arg Arg Ser Lys Asn
 145                 150                 155                 160
 Ser Leu Ser Glu Ile Leu Asn Ser Ile Ser Leu Trp Gln Lys Thr Leu
                 165                 170                 175    
 Lys Ile Ile Gly Gly Lys Phe Gly Thr Ser Val Leu Ser Tyr Phe Asn
             180                 185                 190        
 Phe Leu Arg Trp Leu Leu Lys Phe Asn Ile Phe Ser Phe Ile Leu Asn
         195                 200                 205            
 Phe Ser Phe Ile Ile Ile Pro Gln Phe Thr Val Ala Lys Lys Asn Thr
     210                 215                 220                
 Leu Gln Phe Thr Gly Leu Glu Phe Phe Thr Gly Val Gly Tyr Phe Arg
 225                 230                 235                 240
 Asp Thr Val Met Tyr Tyr Gly Phe Tyr Thr Asn Ser Thr Ile Gln His
                 245                 250                 255    
 Gly Asn Ser Gly Ala Ser Tyr Asn Met Gln Leu Ala Tyr Ile Phe Thr
             260                 265                 270        
 Ile Gly Ala Cys Leu Thr Thr Cys Phe Phe Ser Leu Leu Phe Ser Met
         275                 280                 285            
 Ala Lys Tyr Phe Arg Asn Asn Phe Ile Asn Pro His Ile Tyr Ser Gly
     290                 295                 300                
 Gly Ile Thr Lys Leu Ile Phe Cys Trp Asp Phe Thr Val Thr His Glu
 305                 310                 315                 320
 Lys Ala Val Lys Leu Lys Gln Lys Asn Leu Ser Thr Glu Ile Arg Glu
                 325                 330                 335    
 Asn Leu Ser Glu Leu Arg Gln Glu Asn Ser Lys Leu Thr Phe Asn Gln
             340                 345                 350        
 Leu Leu Thr Arg Phe Ser Ala Tyr Met Val Ala Trp Val Val Ser Thr
         355                 360                 365            
 Gly Val Ala Ile Ala Cys Cys Ala Ala Val Tyr Tyr Leu Ala Glu Tyr
     370                 375                 380                
 Asn Leu Glu Phe Leu Lys Thr His Ser Asn Pro Gly Ala Val Leu Leu
 385                 390                 395                 400
 Leu Pro Phe Val Val Ser Cys Ile Asn Leu Ala Val Pro Cys Ile Tyr
                 405                 410                 415    
 Ser Met Phe Arg Leu Val Glu Arg Tyr Glu Met Pro Arg His Glu Val
             420                 425                 430        
 Tyr Val Leu Leu Ile Arg Asn Ile Phe Leu Lys Ile Ser Ile Ile Gly
         435                 440                 445            
 Ile Leu Cys Tyr Tyr Trp Leu Asn Thr Val Ala Leu Ser Gly Glu Glu
     450                 455                 460                
 Cys Trp Glu Thr Leu Ile Gly Gln Asp Ile Tyr Arg Leu Leu Leu Met
 465                 470                 475                 480
 Asp Phe Val Phe Ser Leu Val Asn Ser Phe Leu Gly Glu Phe Leu Arg
                 485                 490                 495    
 Arg Ile Ile Gly Met Gln Leu Ile Thr Ser Leu Gly Leu Gln Glu Phe
             500                 505                 510        
 Asp Ile Ala Arg Asn Val Leu Glu Leu Ile Tyr Ala Gln Thr Leu Val
         515                 520                 525            
 Trp Ile Gly Ile Phe Phe Cys Pro Leu Leu Pro Phe Ile Gln Met Ile
     530                 535                 540                
 Met Leu Phe Ile Met Phe Tyr Ser Lys Asn Ile Ser Leu Met Met Asn
 545                 550                 555                 560
 Phe Gln Pro Pro Ser Lys Ala Trp Arg Ala Ser Gln Met Met Thr Phe
                 565                 570                 575    
 Phe Ile Phe Leu Leu Phe Phe Pro Ser Phe Thr Gly Val Leu Cys Thr
             580                 585                 590        
 Leu Ala Ile Thr Ile Trp Arg Leu Lys Pro Ser Ala Asp Cys Gly Pro
         595                 600                 605            
 Phe Arg Gly Leu Pro Leu Phe Ile His Ser Ile Tyr Ser Trp Ile Asp
     610                 615                 620                
 Thr Leu Ser Thr Arg Pro Gly Leu Pro Val Gly Cys Leu Asp Leu Ser
 625                 630                 635                 640
 Glu Pro His Trp Lys Cys Ala Leu Leu Phe His Pro His Pro His Cys
                 645                 650                 655    
 Ala Asn His His Leu Ser Leu Leu Ala Asp His Arg Gly Lys Glu Asp
             660                 665                 670        
 Tyr Asp Lys Ala Ala Pro
         675            



      <210> 515
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 515
 Met Glu Pro Ala Ala Gly Ile Gln Arg Arg Ser Ser Gln Gly Pro Thr
   1               5                  10                  15    
 Val Pro Pro Pro Pro Arg Gly His Ala Pro Pro Ala Ala Ala Pro Gly
              20                  25                  30        
 Pro Ala Pro Leu Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu
          35                  40                  45            
 Glu Arg Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu
      50                  55                  60                
 Glu Asp Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu
  65                  70                  75                  80
 Ala Gln Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile
                  85                  90                  95    
 Ile Val Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met
             100                 105                 110        
 Arg Tyr Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp
         115                 120                 125            
 Val Leu Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala
     130                 135                 140                
 Val His Ser Ala His Arg Glu Tyr Ile Ala Cys Val Ile Leu Gly Val
 145                 150                 155                 160
 Ile Phe Leu Leu Ser Ser Ile Cys Ile Val Val Lys Ala Ile His Asp
                 165                 170                 175    
 Leu Ser Thr Arg Leu Leu Pro Glu Val Asp Asp Phe Leu Phe Ser Val
             180                 185                 190        
 Ser Ile Leu Ser Gly Ile Leu Cys Ser Ile Leu Ala Val Leu Lys Phe
         195                 200                 205            
 Met Leu Gly Lys Val Leu Thr Ser Arg Ala Leu Ile Thr Asp Gly Phe
     210                 215                 220                
 Asn Ser Leu Val Gly Gly Val Met Gly Phe Ser Ile Leu Leu Ser Ala
 225                 230                 235                 240
 Glu Val Phe Lys His Asp Ser Ala Val Trp Tyr Leu Asp Gly Ser Ile
                 245                 250                 255    
 Gly Val Leu Ile Gly Leu Thr Ile Phe Ala Tyr Gly Val Lys Leu Leu
             260                 265                 270        
 Ile Asp Met Val Pro Arg Val Arg Gln Thr Arg His Tyr Glu Met Phe
         275                 280                 285            
 Glu
    



      <210> 516
      <211> 823
      <212> PRT
      <213> Homo sapiens


      <400> 516
 Met Ala Leu Arg Arg Ala Val Arg Phe Pro Glu Gly Arg Gly Ala Pro
   1               5                  10                  15    
 Gln Pro Gly Pro Gly Pro Thr Ala Cys Pro Ala Pro Cys His Cys Gln
              20                  25                  30        
 Glu Asp Gly Ile Met Leu Ser Ala Asp Cys Ser Glu Leu Gly Leu Ser
          35                  40                  45            
 Ala Val Pro Gly Asp Leu Asp Pro Leu Thr Ala Tyr Leu Leu Gly Cys
      50                  55                  60                
 Pro Pro Pro Leu Gln Lys Ala Gln Ala Val Gly Gln Thr Trp Glu Asn
  65                  70                  75                  80
 Arg Ser Gln Glu Glu Lys Asn Thr Arg Glu Ala Lys Leu Gly Gln Asp
                  85                  90                  95    
 Leu Asn Tyr Asn Lys Leu Gln Glu Phe Pro Val Ala Ile Arg Thr Leu
             100                 105                 110        
 Gly Arg Leu Gln Glu Leu Gly Phe His Asn Asn Asn Ile Lys Ala Ile
         115                 120                 125            
 Pro Glu Lys Ala Phe Met Gly Asn Pro Leu Leu Gln Thr Ile His Phe
     130                 135                 140                
 Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln Tyr Leu
 145                 150                 155                 160
 Pro Lys Leu His Thr Leu Ser Leu Asn Gly Ala Met Asp Ile Gln Glu
                 165                 170                 175    
 Phe Pro Asp Leu Lys Gly Thr Thr Ser Leu Glu Ile Leu Thr Leu Thr
             180                 185                 190        
 Arg Ala Gly Ile Arg Leu Leu Pro Ser Gly Met Cys Gln Gln Leu Pro
         195                 200                 205            
 Arg Leu Arg Val Leu Glu Leu Ser His Asn Gln Ile Glu Glu Leu Pro
     210                 215                 220                
 Ser Leu His Arg Cys Gln Lys Leu Glu Glu Ile Gly Leu Gln His Asn
 225                 230                 235                 240
 Arg Ile Trp Glu Ile Gly Ala Asp Thr Phe Ser Gln Leu Ser Ser Leu
                 245                 250                 255    
 Gln Ala Leu Asp Leu Ser Trp Asn Ala Ile Arg Ser Ile His Pro Glu
             260                 265                 270        
 Ala Phe Ser Thr Leu His Ser Leu Val Lys Leu Asp Leu Thr Asp Asn
         275                 280                 285            
 Gln Leu Thr Thr Leu Pro Leu Ala Gly Leu Gly Gly Leu Met His Leu
     290                 295                 300                
 Lys Leu Lys Gly Asn Leu Ala Leu Ser Gln Ala Phe Ser Lys Asp Ser
 305                 310                 315                 320
 Phe Pro Lys Leu Arg Ile Leu Glu Val Pro Tyr Ala Tyr Gln Cys Cys
                 325                 330                 335    
 Pro Tyr Gly Met Cys Ala Ser Phe Phe Lys Ala Ser Gly Gln Trp Glu
             340                 345                 350        
 Ala Glu Asp Leu His Leu Asp Asp Glu Glu Ser Ser Lys Arg Pro Leu
         355                 360                 365            
 Gly Leu Leu Ala Arg Gln Ala Glu Asn His Tyr Asp Gln Asp Leu Asp
     370                 375                 380                
 Glu Leu Gln Leu Glu Met Glu Asp Ser Lys Pro His Pro Ser Val Gln
 385                 390                 395                 400
 Cys Ser Pro Thr Pro Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu
                 405                 410                 415    
 Ser Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val
             420                 425                 430        
 Leu Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val
         435                 440                 445            
 Pro Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn
     450                 455                 460                
 Thr Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu
 465                 470                 475                 480
 Thr Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu
                 485                 490                 495    
 Gly Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser
             500                 505                 510        
 Val Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser
         515                 520                 525            
 Cys Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala
     530                 535                 540                
 Gly Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro
 545                 550                 555                 560
 Leu Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr
                 565                 570                 575    
 Ala Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu
             580                 585                 590        
 Val Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile
         595                 600                 605            
 Lys Leu Tyr Cys Asp Leu Pro Arg Gly Asp Phe Glu Ala Val Trp Asp
     610                 615                 620                
 Cys Ala Met Val Arg His Val Ala Trp Leu Ile Phe Ala Asp Gly Leu
 625                 630                 635                 640
 Leu Tyr Cys Pro Val Ala Phe Leu Ser Phe Ala Ser Met Leu Gly Leu
                 645                 650                 655    
 Phe Pro Val Thr Pro Glu Ala Val Lys Ser Val Leu Leu Val Val Leu
             660                 665                 670        
 Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu Tyr Leu Leu Phe Asn Pro
         675                 680                 685            
 His Phe Arg Asp Asp Leu Arg Arg Leu Arg Pro Arg Ala Gly Asp Ser
     690                 695                 700                
 Gly Pro Leu Ala Tyr Ala Ala Ala Gly Glu Leu Glu Lys Ser Ser Cys
 705                 710                 715                 720
 Asp Ser Thr Gln Ala Leu Val Ala Phe Ser Asp Val Asp Leu Ile Leu
                 725                 730                 735    
 Glu Ala Ser Glu Ala Gly Arg Pro Pro Gly Leu Glu Thr Tyr Gly Phe
             740                 745                 750        
 Pro Ser Val Thr Leu Ile Ser Cys Gln Gln Pro Gly Ala Pro Arg Leu
         755                 760                 765            
 Glu Gly Ser His Cys Val Glu Pro Glu Gly Asn His Phe Gly Asn Pro
     770                 775                 780                
 Gln Pro Ser Met Asp Gly Glu Leu Leu Leu Arg Ala Glu Gly Ser Thr
 785                 790                 795                 800
 Pro Ala Gly Gly Gly Leu Ser Gly Gly Gly Gly Phe Gln Pro Ser Gly
                 805                 810                 815    
 Leu Ala Phe Ala Ser His Val
             820            



      <210> 517
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 517
 Met Ala Gly Gly Gly Glu Arg Met Pro Thr Arg Gln Leu His Phe Lys
   1               5                  10                  15    
 Gln Leu Gln Leu Gln Gly Leu Leu Ile Val Ile Ala Val Thr Asp Asn
              20                  25                  30        
 Cys Leu Ser Phe Ser Val Lys Gly Asn Leu Gly Thr Cys Pro Val Arg
          35                  40                  45            
 Ile Leu Val Ala Ser Phe Cys Val His Val Cys Val His Val Arg Val
      50                  55                  60                
 Phe Phe Ile Gln Ile Ser Leu Cys Leu Lys Ser Gly Arg Lys Tyr Phe
  65                  70                  75                  80
 Lys Phe Leu Leu Leu Asn Cys Ala Asn Val Glu Ile Ser Ser
                  85                  90                



      <210> 518
      <211> 699
      <212> PRT
      <213> Homo sapiens


      <400> 518
 Met Arg Pro Leu Thr Cys Asn Ser Phe Thr Glu Ser Leu Pro Glu Gln
   1               5                  10                  15    
 Tyr Tyr Ser Leu Thr Trp Phe Leu Ser Pro Ile Leu Gly Leu Ile Phe
              20                  25                  30        
 Thr Pro Leu Ile Gly Ser Ala Ser Asp Arg Cys Thr Leu Ser Trp Gly
          35                  40                  45            
 Arg Arg Arg Pro Phe Ile Leu Ala Leu Cys Val Gly Val Leu Phe Gly
      50                  55                  60                
 Val Ala Leu Phe Leu Asn Gly Ser Ala Ile Gly Leu Ala Leu Gly Asp
  65                  70                  75                  80
 Val Pro Asn Arg Gln Pro Ile Gly Ile Val Leu Thr Val Leu Gly Val
                  85                  90                  95    
 Val Val Leu Asp Phe Ser Ala Asp Ala Thr Glu Gly Pro Ile Arg Ala
             100                 105                 110        
 Tyr Leu Leu Asp Val Val Asp Ser Glu Glu Gln Asp Met Ala Leu Asn
         115                 120                 125            
 Ile His Ala Phe Ser Ala Gly Leu Gly Gly Ala Ile Gly Tyr Val Leu
     130                 135                 140                
 Gly Gly Leu Asp Trp Thr Gln Thr Phe Leu Gly Ser Trp Phe Arg Thr
 145                 150                 155                 160
 Gln Asn Gln Val Leu Phe Phe Phe Ala Ala Ile Ile Phe Thr Val Ser
                 165                 170                 175    
 Val Ala Leu His Leu Phe Ser Ile Asp Glu Glu Gln Tyr Ser Pro Gln
             180                 185                 190        
 Gln Glu Arg Ser Ala Glu Glu Pro Gly Ala Leu Asp Gly Gly Glu Pro
         195                 200                 205            
 His Gly Val Pro Ala Phe Pro Asp Glu Val Gln Ser Glu His Glu Leu
     210                 215                 220                
 Ala Leu Asp Tyr Pro Asp Val Asp Ile Met Arg Ser Lys Ser Asp Ser
 225                 230                 235                 240
 Ala Leu His Val Pro Asp Thr Ala Leu Asp Leu Glu Pro Glu Leu Leu
                 245                 250                 255    
 Phe Leu His Asp Ile Glu Pro Ser Ile Phe His Asp Ala Ser Tyr Pro
             260                 265                 270        
 Ala Thr Pro Arg Ser Thr Ser Gln Glu Leu Ala Lys Thr Lys Leu Pro
         275                 280                 285            
 Arg Leu Ala Thr Phe Leu Lys Glu Ala Ala Lys Glu Asp Glu Thr Leu
     290                 295                 300                
 Leu Asp Asn His Leu Asn Glu Ala Lys Val Pro Asn Gly Ser Gly Ser
 305                 310                 315                 320
 Pro Thr Lys Asp Ala Leu Gly Gly Tyr Thr Arg Val Asp Thr Lys Pro
                 325                 330                 335    
 Ser Ala Thr Ser Ser Ser Met Arg Arg Arg Arg His Ala Phe Arg Arg
             340                 345                 350        
 Gln Ala Ser Ser Thr Phe Ser Tyr Tyr Gly Lys Leu Gly Ser His Cys
         355                 360                 365            
 Tyr Arg Tyr Arg Arg Ala Asn Ala Val Val Leu Ile Lys Pro Ser Arg
     370                 375                 380                
 Ser Met Ser Asp Leu Tyr Asp Met Gln Lys Arg Gln Arg Gln His Arg
 385                 390                 395                 400
 His Arg Asn Gln Ser Gly Ala Thr Thr Ser Ser Gly Asp Thr Glu Ser
                 405                 410                 415    
 Glu Glu Gly Glu Gly Glu Thr Thr Val Arg Leu Leu Trp Leu Ser Met
             420                 425                 430        
 Leu Lys Met Pro Arg Glu Leu Met Arg Leu Cys Leu Cys His Leu Leu
         435                 440                 445            
 Thr Trp Phe Ser Val Ile Ala Glu Ala Val Phe Tyr Thr Asp Phe Met
     450                 455                 460                
 Gly Gln Val Ile Phe Glu Gly Asp Pro Lys Ala Pro Ser Asn Ser Thr
 465                 470                 475                 480
 Ala Trp Gln Ala Tyr Asn Ala Gly Val Lys Met Gly Cys Trp Gly Leu
                 485                 490                 495    
 Val Ile Tyr Ala Ala Thr Gly Ala Ile Cys Ser Ala Leu Leu Gln Lys
             500                 505                 510        
 Tyr Leu Asp Asn Tyr Asp Leu Ser Val Arg Val Ile Tyr Val Leu Gly
         515                 520                 525            
 Thr Leu Gly Phe Ser Val Gly Thr Ala Val Met Ala Met Phe Pro Asn
     530                 535                 540                
 Val Tyr Val Ala Met Val Thr Ile Ser Thr Met Gly Ile Val Ser Met
 545                 550                 555                 560
 Ser Ile Ser Tyr Cys Pro Tyr Ala Leu Leu Gly Gln Tyr His Asp Ile
                 565                 570                 575    
 Lys Gln Tyr Ile His His Ser Pro Gly Asn Ser Lys Arg Gly Phe Gly
             580                 585                 590        
 Ile Asp Cys Ala Ile Leu Ser Cys Gln Val Tyr Ile Ser Gln Ile Leu
         595                 600                 605            
 Val Ala Ser Ala Leu Gly Gly Val Val Asp Ala Val Gly Thr Val Arg
     610                 615                 620                
 Val Ile Pro Met Val Ala Ser Val Gly Ser Phe Leu Gly Phe Leu Thr
 625                 630                 635                 640
 Ala Thr Phe Leu Val Ile Tyr Pro Asp Val Ser Glu Glu Ala Lys Glu
                 645                 650                 655    
 Glu Gln Lys Gly Leu Ser Ser Pro Leu Ala Gly Glu Gly Arg Ala Gly
             660                 665                 670        
 Gly Asn Ser Glu Lys Pro Thr Val Leu Lys Leu Thr Arg Lys Glu Gly
         675                 680                 685            
 Leu Gln Gly Pro Val Glu Thr Glu Ser Val Val
     690                 695                



      <210> 519
      <211> 803
      <212> PRT
      <213> Homo sapiens


      <400> 519
 Met Ser Ser Ser Ala Ala Gly Ala Pro Asp Gln Ala Ile Ser Ile Ser
   1               5                  10                  15    
 Leu Glu Ala Gln Gly Gln Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly
              20                  25                  30        
 Ser Gly Gln Leu Leu Asp Gln Glu Asn Gly Ala Gly Gly Glu Tyr Met
          35                  40                  45            
 Ser Cys Phe Glu Ala Gln Gly Phe Lys Trp Asn Leu Tyr Glu Val Val
      50                  55                  60                
 Arg Val Pro Leu Lys Ala Thr Asp Val Ala Arg Leu Pro Tyr Gln Leu
  65                  70                  75                  80
 Ser Ile Ser Cys Ala Thr Ser Pro Gly Phe Gln Leu Ser Cys Cys Ile
                  85                  90                  95    
 Pro Ser Thr Asn Leu Ala Tyr Thr Ala Ala Trp Ser Pro Gly Glu Gly
             100                 105                 110        
 Ser Lys Ala Ser Ser Phe Asn Glu Ser Gly Ser Gln Cys Phe Val Leu
         115                 120                 125            
 Ala Val Gln Arg Cys Pro Met Ala Asp Thr Thr Tyr Ala Cys Asp Leu
     130                 135                 140                
 Gln Ser Leu Gly Leu Ala Pro Leu Arg Val Pro Ile Ser Ile Thr Ile
 145                 150                 155                 160
 Ile Gln Asp Gly Asp Ile Thr Cys Pro Glu Asp Ala Ser Val Leu Thr
                 165                 170                 175    
 Trp Asn Val Thr Lys Ala Gly His Val Ala Gln Ala Pro Cys Pro Glu
             180                 185                 190        
 Ser Lys Arg Gly Ile Val Arg Arg Leu Cys Gly Ala Asp Gly Val Trp
         195                 200                 205            
 Gly Pro Val His Ser Ser Cys Thr Asp Ala Arg Leu Leu Ala Leu Phe
     210                 215                 220                
 Thr Arg Thr Lys Leu Leu Gln Ala Gly Gln Gly Ser Pro Ala Glu Glu
 225                 230                 235                 240
 Val Pro Gln Ile Leu Ala Gln Leu Pro Gly Gln Ala Ala Glu Ala Ser
                 245                 250                 255    
 Ser Pro Ser Asp Leu Leu Thr Leu Leu Ser Thr Met Lys Tyr Val Ala
             260                 265                 270        
 Lys Val Val Ala Glu Ala Arg Ile Gln Leu Asp Arg Arg Ala Leu Lys
         275                 280                 285            
 Asn Leu Leu Ile Ala Thr Asp Lys Val Leu Asp Met Asp Thr Arg Ser
     290                 295                 300                
 Leu Trp Thr Leu Ala Gln Ala Arg Lys Pro Trp Ala Gly Ser Thr Leu
 305                 310                 315                 320
 Leu Leu Ala Val Glu Thr Leu Ala Cys Ser Leu Cys Pro Gln Asp His
                 325                 330                 335    
 Pro Phe Ala Phe Ser Leu Pro Asn Val Leu Leu Gln Ser Gln Leu Phe
             340                 345                 350        
 Gly Pro Thr Phe Pro Ala Asp Tyr Ser Ile Ser Phe Pro Thr Arg Pro
         355                 360                 365            
 Pro Leu Gln Ala Gln Ile Pro Arg His Ser Leu Ala Pro Leu Val Arg
     370                 375                 380                
 Asn Gly Thr Glu Ile Ser Ile Thr Ser Leu Val Leu Arg Lys Leu Asp
 385                 390                 395                 400
 His Leu Leu Pro Ser Asn Tyr Gly Gln Gly Leu Gly Asp Ser Leu Tyr
                 405                 410                 415    
 Ala Thr Pro Gly Leu Val Leu Val Ile Ser Ile Met Ala Gly Asp Arg
             420                 425                 430        
 Ala Phe Ser Gln Gly Glu Val Ile Met Asp Phe Gly Asn Thr Asp Gly
         435                 440                 445            
 Ser Pro His Cys Val Phe Trp Asp His Ser Leu Phe Gln Gly Arg Gly
     450                 455                 460                
 Gly Trp Ser Lys Glu Gly Cys Gln Ala Gln Val Ala Ser Ala Ser Pro
 465                 470                 475                 480
 Thr Ala Gln Cys Leu Cys Gln His Leu Thr Ala Phe Ser Val Leu Met
                 485                 490                 495    
 Ser Pro His Thr Val Pro Glu Glu Pro Ala Leu Ala Leu Leu Thr Gln
             500                 505                 510        
 Val Gly Leu Gly Ala Ser Ile Leu Ala Leu Leu Val Cys Leu Gly Val
         515                 520                 525            
 Tyr Trp Leu Val Trp Arg Val Val Val Arg Asn Lys Ile Ser Tyr Phe
     530                 535                 540                
 Arg His Ala Ala Leu Leu Asn Met Val Phe Cys Leu Leu Ala Ala Asp
 545                 550                 555                 560
 Thr Cys Phe Leu Gly Ala Pro Phe Leu Ser Pro Gly Pro Arg Ser Pro
                 565                 570                 575    
 Leu Cys Leu Ala Ala Ala Phe Leu Cys His Phe Leu Tyr Leu Ala Thr
             580                 585                 590        
 Phe Phe Trp Met Leu Ala Gln Ala Leu Val Leu Ala His Gln Leu Leu
         595                 600                 605            
 Phe Val Phe His Gln Leu Ala Lys His Arg Val Leu Pro Leu Met Val
     610                 615                 620                
 Leu Leu Gly Tyr Leu Cys Pro Leu Gly Leu Ala Gly Val Thr Leu Gly
 625                 630                 635                 640
 Leu Tyr Leu Pro Gln Gly Gln Tyr Leu Arg Glu Gly Glu Cys Trp Leu
                 645                 650                 655    
 Asp Gly Lys Gly Gly Ala Leu Tyr Thr Phe Val Gly Pro Val Leu Ala
             660                 665                 670        
 Ile Ile Gly Val Asn Gly Leu Val Leu Ala Met Ala Met Leu Lys Leu
         675                 680                 685            
 Leu Arg Pro Ser Leu Ser Glu Gly Pro Pro Ala Glu Lys Arg Gln Ala
     690                 695                 700                
 Leu Leu Gly Val Ile Lys Ala Leu Leu Ile Leu Thr Pro Ile Phe Gly
 705                 710                 715                 720
 Leu Thr Trp Gly Leu Gly Leu Ala Thr Leu Leu Glu Glu Val Ser Thr
                 725                 730                 735    
 Val Pro His Tyr Ile Phe Thr Ile Leu Asn Thr Leu Gln Gly Val Phe
             740                 745                 750        
 Ile Leu Leu Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu Ala Leu
         755                 760                 765            
 Arg Lys Arg Phe Cys Arg Ala Gln Ala Pro Ser Ser Thr Ile Ser Leu
     770                 775                 780                
 Ala Thr Asn Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly Ser Asp
 785                 790                 795                 800
 Thr Ala Arg
            



      <210> 520
      <211> 224
      <212> PRT
      <213> Homo sapiens


      <400> 520
 Met Asn Ile Glu Val Gly Asn Ile Ser Tyr Thr Gly Ala Ile Ile Ser
   1               5                  10                  15    
 Trp Ser Ser Ser Glu Pro Cys Leu Glu Asp Tyr Tyr His Ile Met Tyr
              20                  25                  30        
 Arg Pro Asn Trp Asn Ser Ile Phe Ser Gly Tyr Leu Arg Tyr Ser Phe
          35                  40                  45            
 His His Glu Glu Lys Val Pro Arg Thr Ile Ser Ser Val Val Leu Glu
      50                  55                  60                
 His Leu Ala Pro Ser Thr Leu Tyr Phe Leu Cys Ile Ser Cys Lys Lys
  65                  70                  75                  80
 Ala Ala Phe Pro Tyr Arg His Tyr Cys Thr Met Phe His Thr Leu Asp
                  85                  90                  95    
 Lys Ser Pro Leu Ala Pro Gly Ser Ser Leu Val Asp Pro Gln Ile Ser
             100                 105                 110        
 Leu Trp Val Leu Met Ala Ile Leu Leu Ala Cys Phe Thr Ala Val Leu
         115                 120                 125            
 Ala Phe Ile Cys Leu Gln Phe Trp Cys Val Arg Cys His Glu Pro Arg
     130                 135                 140                
 Trp Ser Tyr Arg Ala Gly His Met Glu Glu Ala Asn Gly Leu Val Arg
 145                 150                 155                 160
 Trp Pro Glu Glu Ala Pro Asp Leu Gly Gln Arg Glu Glu Asp Leu Gln
                 165                 170                 175    
 Gly Leu Pro Leu Val Glu Met Pro Arg Lys Asn Ser Arg Asp Gly Ala
             180                 185                 190        
 Glu Leu Asp Pro Glu Ala Asn Gln Asp Ala Pro Asp Ala Gly Ala Leu
         195                 200                 205            
 Gln Arg Gly Gly Gly Asp Pro Pro Ala Ile Leu Pro His Cys Gly Glu
     210                 215                 220                





      <210> 521
      <211> 289
      <212> PRT
      <213> Homo sapiens


      <400> 521
 Met Pro Lys Asn Ser Lys Val Val Lys Arg Glu Leu Asp Asp Asp Val
   1               5                  10                  15    
 Thr Glu Ser Val Lys Asp Leu Leu Ser Asn Glu Asp Ala Ala Asp Asp
              20                  25                  30        
 Ala Phe Lys Thr Ser Glu Leu Ile Val Asp Gly Gln Glu Glu Lys Asp
          35                  40                  45            
 Thr Asp Val Glu Glu Gly Ser Glu Val Glu Asp Glu Arg Pro Ala Trp
      50                  55                  60                
 Asn Ser Lys Leu Gln Tyr Ile Leu Ala Gln Val Gly Phe Ser Val Gly
  65                  70                  75                  80
 Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Lys Asn Gly Gly
                  85                  90                  95    
 Gly Ala Tyr Leu Leu Pro Tyr Leu Ile Leu Leu Met Val Ile Gly Ile
             100                 105                 110        
 Pro Leu Phe Phe Leu Glu Leu Ser Val Gly Gln Arg Ile Arg Arg Gly
         115                 120                 125            
 Ser Ile Gly Val Trp Asn Tyr Ile Ser Pro Lys Leu Gly Gly Ile Gly
     130                 135                 140                
 Phe Ala Ser Cys Val Val Cys Tyr Phe Val Ala Leu Tyr Tyr Asn Val
 145                 150                 155                 160
 Ile Ile Gly Trp Ser Leu Phe Tyr Phe Ser Gln Ser Phe Gln Gln Pro
                 165                 170                 175    
 Leu Pro Trp Asp Gln Cys Pro Leu Val Lys Asn Ala Ser His Thr Phe
             180                 185                 190        
 Val Glu Pro Glu Cys Glu Gln Ser Ser Ala Thr Thr Tyr Tyr Trp Tyr
         195                 200                 205            
 Arg Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser Glu Ser Gly Gly Leu
     210                 215                 220                
 Asn Trp Lys Met Thr Ile Cys Leu Leu Ala Ala Trp Val Met Val Cys
 225                 230                 235                 240
 Leu Ala Met Ile Lys Gly Ile Gln Ser Ser Gly Lys Val Ser Met Leu
                 245                 250                 255    
 Glu Pro Phe Leu Ile Leu Leu Ile Thr Ile Ser Gly Phe Ile Pro Leu
             260                 265                 270        
 Ser Asn Ser Val Thr Asp Phe Cys Gly Gln Ile Thr His Asn Thr Ser
         275                 280                 285            
 Phe
    



      <210> 522
      <211> 502
      <212> PRT
      <213> Homo sapiens


      <400> 522
 Met Val Lys Gly Leu Pro Gln Lys Thr Leu Leu Gly Gln Gly Tyr Gln
   1               5                  10                  15    
 Ala Pro Leu Ser Ala Lys Val Phe Ser Ser Trp Asp Phe Cys Ile Arg
              20                  25                  30        
 Val Gln Glu Ala Ala Thr Ile Lys Lys His Glu Ile Ser Asn Glu Phe
          35                  40                  45            
 Lys Val Glu Leu Glu Glu Gly Arg Arg Phe Gln Leu Met Gln Gln Gln
      50                  55                  60                
 Thr Arg Ala Gln Thr Ala Cys Arg Leu Leu Ser Tyr Leu Arg Val Asn
  65                  70                  75                  80
 Val Leu Ile Gly Leu Leu Val Val Gly Ala Ile Ser Ala Ile Phe Trp
                  85                  90                  95    
 Ala Thr Lys Tyr Ser Gln Asp Asn Lys Glu Glu Ser Leu Phe Leu Leu
             100                 105                 110        
 Leu Gln Tyr Leu Pro Pro Gly Val Ile Ala Leu Val Asn Phe Leu Gly
         115                 120                 125            
 Pro Leu Leu Phe Thr Phe Leu Val Gln Leu Glu Asn Tyr Pro Pro Asn
     130                 135                 140                
 Thr Glu Val Asn Leu Thr Leu Ile Trp Cys Val Val Leu Lys Leu Ala
 145                 150                 155                 160
 Ser Leu Gly Met Phe Ser Val Ser Leu Gly Gln Thr Ile Leu Cys Ile
                 165                 170                 175    
 Gly Arg Asp Lys Ser Ser Cys Glu Ser Tyr Gly Tyr Asn Val Cys Asp
             180                 185                 190        
 Tyr Gln Cys Trp Glu Asn Ser Val Gly Glu Glu Leu Tyr Lys Leu Ser
         195                 200                 205            
 Ile Phe Asn Phe Leu Leu Thr Val Ala Phe Ala Phe Leu Val Thr Leu
     210                 215                 220                
 Pro Arg Arg Leu Leu Val Asp Arg Phe Ser Gly Arg Phe Trp Ala Trp
 225                 230                 235                 240
 Leu Glu Arg Glu Glu Phe Leu Val Pro Lys Asn Val Leu Asp Ile Val
                 245                 250                 255    
 Ala Gly Gln Thr Val Thr Trp Met Gly Leu Phe Tyr Cys Pro Leu Leu
             260                 265                 270        
 Pro Leu Leu Asn Ser Val Phe Leu Phe Leu Thr Phe Tyr Ile Lys Lys
         275                 280                 285            
 Tyr Thr Leu Leu Lys Asn Ser Arg Ala Ser Ser Arg Pro Phe Arg Ala
     290                 295                 300                
 Ser Ser Ser Thr Phe Phe Phe Gln Leu Val Leu Leu Leu Gly Leu Leu
 305                 310                 315                 320
 Leu Ala Ala Val Pro Leu Gly Tyr Val Val Ser Ser Ile His Ser Ser
                 325                 330                 335    
 Trp Asp Cys Gly Leu Phe Thr Asn Tyr Ser Ala Pro Trp Gln Val Val
             340                 345                 350        
 Pro Glu Leu Val Ala Leu Gly Leu Pro Pro Ile Gly Gln Arg Ala Leu
         355                 360                 365            
 His Tyr Leu Gly Ser His Ala Phe Ser Phe Pro Leu Leu Ile Met Leu
     370                 375                 380                
 Ser Leu Val Leu Thr Val Cys Val Ser Gln Thr Gln Ala Asn Ala Arg
 385                 390                 395                 400
 Ala Ile His Arg Leu Arg Lys Gln Leu Val Trp Val Gln Glu Lys Trp
                 405                 410                 415    
 His Leu Val Glu Asp Leu Ser Arg Leu Leu Pro Glu Pro Gly Pro Ser
             420                 425                 430        
 Asp Ser Pro Gly Pro Lys Tyr Pro Ala Ser Gln Ala Ser Arg Pro Gln
         435                 440                 445            
 Ser Phe Cys Pro Gly Cys Pro Cys Pro Gly Ser Pro Gly His His Gly
     450                 455                 460                
 Pro Ala Ala Gly Pro Ser Val Val Asp Ala Ala Gly Leu Arg Ser Pro
 465                 470                 475                 480
 Cys Pro Gly Gln His Gly Ala Pro Ala Pro Pro Gln Ile Pro Leu Pro
                 485                 490                 495    
 Pro Ala Ala Arg Ser Leu
             500        



      <210> 523
      <211> 287
      <212> PRT
      <213> Homo sapiens


      <400> 523
 Met Ala Ala Pro Ala Pro Gly Ala Gly Ala Ala Ser Gly Gly Ala Gly
   1               5                  10                  15    
 Cys Ser Gly Gly Gly Ala Gly Ala Gly Ala Gly Ser Gly Ser Gly Ala
              20                  25                  30        
 Ala Gly Ala Gly Gly Pro Gly Cys Pro Ala Gly Cys Trp Met Leu Val
          35                  40                  45            
 Phe Ser Tyr Leu Glu Leu Ser Glu Leu Arg Ser Cys Ala Leu Val Cys
      50                  55                  60                
 Lys His Trp Tyr Arg Cys Leu His Gly Asp Glu Asn Ser Glu Val Trp
  65                  70                  75                  80
 Arg Ser Leu Cys Ala Arg Ser Leu Ala Glu Glu Ala Leu Arg Thr Asp
                  85                  90                  95    
 Ile Leu Cys Asn Leu Pro Ser Tyr Lys Ala Lys Ile Arg Ala Phe Gln
             100                 105                 110        
 His Ala Phe Ser Thr Asn Asp Cys Ser Arg Asn Val Tyr Ile Lys Lys
         115                 120                 125            
 Asn Gly Phe Thr Leu His Arg Asn Pro Ile Ala Gln Ser Thr Asp Gly
     130                 135                 140                
 Ala Arg Thr Lys Ile Gly Phe Ser Glu Gly Arg His Ala Trp Glu Val
 145                 150                 155                 160
 Trp Trp Glu Gly Pro Leu Gly Thr Val Ala Val Ile Gly Ile Ala Thr
                 165                 170                 175    
 Lys Arg Ala Pro Met Gln Cys Gln Gly Tyr Val Ala Leu Leu Gly Ser
             180                 185                 190        
 Asp Asp Gln Ser Trp Gly Trp Asn Leu Val Asp Asn Asn Leu Leu His
         195                 200                 205            
 Asn Gly Glu Val Asn Gly Ser Phe Pro Gln Cys Asn Asn Ala Pro Lys
     210                 215                 220                
 Tyr Gln Ile Gly Glu Arg Ile Arg Val Ile Leu Asp Met Glu Asp Lys
 225                 230                 235                 240
 Thr Leu Ala Phe Glu Arg Gly Tyr Glu Phe Leu Gly Val Ala Phe Arg
                 245                 250                 255    
 Gly Leu Pro Lys Val Cys Leu Tyr Pro Ala Val Ser Ala Val Tyr Gly
             260                 265                 270        
 Asn Thr Glu Val Thr Leu Val Tyr Leu Gly Lys Pro Leu Asp Gly
         275                 280                 285        



      <210> 524
      <211> 389
      <212> PRT
      <213> Homo sapiens


      <400> 524
 Met Gly Phe Met Asp Asp Asn Ala Thr Asn Thr Ser Thr Ser Phe Leu
   1               5                  10                  15    
 Ser Val Leu Asn Pro His Gly Ala His Ala Thr Ser Phe Pro Phe Asn
              20                  25                  30        
 Phe Ser Tyr Ser Asp Tyr Asp Met Pro Leu Asp Glu Asp Glu Asp Val
          35                  40                  45            
 Thr Asn Ser Arg Thr Phe Phe Ala Ala Lys Ile Val Ile Gly Met Ala
      50                  55                  60                
 Leu Val Gly Ile Met Leu Val Cys Gly Ile Gly Asn Phe Ile Phe Ile
  65                  70                  75                  80
 Ala Ala Leu Val Arg Tyr Lys Lys Leu Arg Asn Leu Thr Asn Leu Leu
                  85                  90                  95    
 Ile Ala Asn Leu Ala Ile Ser Asp Phe Leu Val Ala Ile Val Cys Cys
             100                 105                 110        
 Pro Phe Glu Met Asp Tyr Tyr Val Val Arg Gln Leu Ser Trp Glu His
         115                 120                 125            
 Gly His Val Leu Cys Thr Ser Val Asn Tyr Leu Arg Thr Val Ser Leu
     130                 135                 140                
 Tyr Val Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile Asp Arg Tyr Leu
 145                 150                 155                 160
 Ala Ile Val His Pro Leu Lys Pro Arg Met Asn Tyr Gln Thr Ala Ser
                 165                 170                 175    
 Phe Leu Ile Ala Leu Val Trp Met Val Ser Ile Leu Ile Ala Ile Pro
             180                 185                 190        
 Ser Ala Tyr Phe Ala Thr Glu Thr Val Leu Phe Ile Val Lys Ser Gln
         195                 200                 205            
 Glu Lys Ile Phe Cys Gly Gln Ile Trp Pro Val Asp Gln Gln Leu Tyr
     210                 215                 220                
 Tyr Lys Ser Tyr Phe Leu Phe Ile Phe Gly Val Glu Phe Val Gly Pro
 225                 230                 235                 240
 Val Val Thr Met Thr Leu Cys Tyr Ala Arg Ile Ser Arg Glu Leu Trp
                 245                 250                 255    
 Phe Lys Ala Val Pro Gly Phe Gln Thr Glu Gln Ile Arg Lys Arg Leu
             260                 265                 270        
 Arg Cys Arg Arg Lys Thr Val Leu Val Leu Met Cys Ile Leu Thr Ala
         275                 280                 285            
 Tyr Val Leu Cys Trp Ala Pro Phe Tyr Gly Phe Thr Ile Val Arg Asp
     290                 295                 300                
 Phe Phe Pro Thr Val Phe Val Lys Glu Lys His Tyr Leu Thr Ala Phe
 305                 310                 315                 320
 Tyr Val Val Glu Cys Ile Ala Met Ser Asn Ser Met Ile Asn Thr Val
                 325                 330                 335    
 Cys Phe Val Thr Val Lys Asn Asn Thr Met Lys Tyr Phe Lys Lys Met
             340                 345                 350        
 Met Leu Leu His Trp Arg Pro Ser Gln Arg Gly Ser Lys Ser Ser Ala
         355                 360                 365            
 Asp Leu Asp Leu Arg Thr Asn Gly Val Pro Thr Thr Glu Glu Val Asp
     370                 375                 380                
 Cys Ile Arg Leu Lys
 385                



      <210> 525
      <211> 351
      <212> PRT
      <213> Homo sapiens


      <400> 525
 Met Thr Trp Ser Ala Thr Ala Arg Gly Ala His Gln Pro Asp Asn Thr
   1               5                  10                  15    
 Ala Phe Thr Gln Gln Arg Leu Pro Ala Trp Gln Pro Leu Leu Ser Ala
              20                  25                  30        
 Ser Ile Ala Leu Pro Leu Phe Phe Cys Ala Gly Leu Ala Phe Ile Gly
          35                  40                  45            
 Leu Gly Leu Gly His Tyr Tyr Ser Ser Asn Gly Ile Lys Glu Leu Glu
      50                  55                  60                
 Tyr Asp Tyr Thr Gly Asp Pro Gly Thr Gly Asn Cys Ser Val Cys Ala
  65                  70                  75                  80
 Ala Ala Gly Gln Gly Arg Ala Leu Pro Pro Pro Cys Ser Cys Ala Trp
                  85                  90                  95    
 Tyr Phe Ser Leu Pro Glu Leu Phe Gln Gly Pro Val Tyr Leu Tyr Tyr
             100                 105                 110        
 Glu Leu Thr Asn Phe Tyr Gln Asn Asn Arg Arg Tyr Gly Val Ser Arg
         115                 120                 125            
 Asp Asp Ala Gln Leu Ser Gly Leu Pro Ser Ala Leu Arg His Pro Val
     130                 135                 140                
 Asn Glu Cys Ala Pro Tyr Gln Arg Ser Ala Ala Gly Leu Pro Ile Ala
 145                 150                 155                 160
 Pro Cys Gly Ala Ile Ala Asn Ser Leu Phe Asn Asp Ser Phe Ser Leu
                 165                 170                 175    
 Trp His Gln Arg Gln Pro Gly Gly Pro Tyr Val Glu Val Pro Leu Asp
             180                 185                 190        
 Arg Ser Gly Ile Ala Trp Trp Thr Asp Tyr His Val Lys Phe Arg Asn
         195                 200                 205            
 Pro Pro Leu Val Asn Gly Ser Leu Ala Leu Ala Phe Gln Gly Thr Ala
     210                 215                 220                
 Pro Pro Pro Asn Trp Arg Arg Pro Val Tyr Glu Leu Ser Pro Asp Pro
 225                 230                 235                 240
 Asn Asn Thr Gly Phe Ile Asn Gln Asp Phe Val Val Trp Met Arg Thr
                 245                 250                 255    
 Ala Ala Leu Pro Thr Phe Arg Lys Leu Tyr Ala Arg Ile Arg Gln Gly
             260                 265                 270        
 Asn Tyr Ser Ala Gly Leu Pro Arg Gly Ala Tyr Arg Val Asn Ile Thr
         275                 280                 285            
 Tyr Asn Tyr Pro Val Arg Ala Phe Gly Gly His Lys Leu Leu Ile Phe
     290                 295                 300                
 Ser Ser Ile Ser Trp Met Gly Gly Lys Asn Pro Phe Leu Gly Ile Ala
 305                 310                 315                 320
 Tyr Leu Val Val Gly Ser Leu Cys Ile Leu Thr Gly Phe Val Met Leu
                 325                 330                 335    
 Val Val Tyr Ile Arg Tyr Gln Asp Gln Asp Asp Asp Asp Glu Glu
             340                 345                 350    



      <210> 526
      <211> 389
      <212> PRT
      <213> Homo sapiens


      <400> 526
 Met Ala Val Tyr Asn Lys Lys Glu Asp Leu Gly Gln Val Met Cys Tyr
   1               5                  10                  15    
 Leu Leu Tyr Phe His Gln Leu Gly Val Asn Pro Thr Arg Pro Ile Ala
              20                  25                  30        
 Lys Gly Asn Gly Asp Phe Pro Ser Met Pro Gly His Asn Thr Ser Arg
          35                  40                  45            
 Asn Ser Ser Cys Asp Pro Ile Val Thr Pro His Leu Ile Ser Leu Tyr
      50                  55                  60                
 Phe Ile Val Leu Ile Gly Gly Leu Val Gly Val Ile Ser Ile Leu Phe
  65                  70                  75                  80
 Leu Leu Val Lys Met Asn Thr Arg Ser Val Thr Thr Met Ala Val Ile
                  85                  90                  95    
 Asn Leu Val Val Val His Ser Val Phe Leu Leu Thr Val Pro Phe Arg
             100                 105                 110        
 Leu Thr Tyr Leu Ile Lys Lys Thr Trp Met Phe Gly Leu Pro Phe Cys
         115                 120                 125            
 Lys Phe Val Ser Ala Met Leu His Ile His Met Tyr Leu Thr Phe Leu
     130                 135                 140                
 Phe Tyr Val Val Ile Leu Val Thr Arg Tyr Leu Ile Phe Phe Lys Cys
 145                 150                 155                 160
 Lys Asp Lys Val Glu Phe Tyr Arg Lys Leu His Ala Val Ala Ala Ser
                 165                 170                 175    
 Ala Gly Met Trp Thr Leu Val Ile Val Ile Val Val Pro Leu Val Val
             180                 185                 190        
 Ser Arg Tyr Gly Ile His Glu Glu Tyr Asn Glu Glu His Cys Phe Lys
         195                 200                 205            
 Phe His Lys Glu Leu Ala Tyr Thr Tyr Val Lys Ile Ile Asn Tyr Met
     210                 215                 220                
 Ile Val Ile Phe Val Ile Ala Val Ala Val Ile Leu Leu Val Phe Gln
 225                 230                 235                 240
 Val Phe Ile Ile Met Leu Met Pro Thr Ser His Thr His Thr Pro Ser
                 245                 250                 255    
 Thr Glu Met Gln Thr Leu Gln Glu Arg Val Gly Pro Leu Asp Asp Gly
             260                 265                 270        
 Glu Val His Lys Gly Ala Leu Leu Met Glu Leu Ala Glu Lys Pro Leu
         275                 280                 285            
 Ile Gly Val Leu Glu Lys Ala Val Gln Gly Glu Lys Leu His Leu Arg
     290                 295                 300                
 Pro Cys Trp Ala Ser Ala Gln Gly Thr Glu Cys Leu Trp Lys Leu Leu
 305                 310                 315                 320
 Ser Glu Gly Gln Gly Trp Leu Ser Thr Arg Arg Pro His Ala Leu Arg
                 325                 330                 335    
 Ala Leu Gly Arg Ser Leu Leu Arg Glu Ser Arg Tyr Gln Ser Gln Gly
             340                 345                 350        
 Glu Lys Pro Ile Leu Pro Gln Val Leu Leu Gln Arg Leu Val Met Met
         355                 360                 365            
 Lys Ile Ser Leu Ala Ser His Pro Leu Val Arg Glu Lys Arg Ala Ser
     370                 375                 380                
 Phe Met Ala Gly Gln
 385                



      <210> 527
      <211> 505
      <212> PRT
      <213> Homo sapiens


      <400> 527
 Met Thr Ser Ser Leu Tyr Phe Ile Thr Phe Gly Met Gly Ala Ser Pro
   1               5                  10                  15    
 Phe Thr Asn Ile Glu Ala Val Lys Val Phe Cys Gln Asn Met Cys Val
              20                  25                  30        
 Ser Ile Leu Leu Asn Tyr Phe Tyr Ile Phe Ser Phe Phe Gly Ser Cys
          35                  40                  45            
 Leu Val Phe Ala Gly Gln Leu Glu Gln Asn Arg Tyr His Ser Ile Phe
      50                  55                  60                
 Cys Cys Lys Ile Pro Ser Ala Glu Tyr Leu Asp Arg Lys Pro Val Trp
  65                  70                  75                  80
 Phe Gln Thr Val Met Ser Asp Gly His Gln Gln Thr Ser His His Glu
                  85                  90                  95    
 Thr Asn Pro Tyr Gln His His Phe Ile Gln His Phe Leu Arg Glu His
             100                 105                 110        
 Tyr Asn Glu Trp Ile Thr Asn Ile Tyr Val Lys Pro Phe Val Val Ile
         115                 120                 125            
 Leu Tyr Leu Ile Tyr Ala Ser Phe Ser Phe Met Gly Cys Leu Gln Ile
     130                 135                 140                
 Ser Asp Gly Ala Asn Ile Ile Asn Leu Leu Ala Ser Asp Ser Pro Ser
 145                 150                 155                 160
 Val Ser Tyr Ala Met Val Gln Gln Lys Tyr Phe Ser Asn Tyr Ser Pro
                 165                 170                 175    
 Val Ile Gly Phe Tyr Val Tyr Glu Pro Leu Glu Tyr Trp Asn Ser Ser
             180                 185                 190        
 Val Gln Asp Asp Leu Arg Arg Leu Cys Ser Gly Phe Thr Ala Val Ser
         195                 200                 205            
 Trp Val Glu Gln Tyr Tyr Gln Phe Leu Lys Val Ser Asn Val Ser Ala
     210                 215                 220                
 Asn Asn Lys Ser Asp Phe Ile Ser Val Leu Gln Ser Ser Phe Leu Lys
 225                 230                 235                 240
 Lys Pro Glu Phe Gln His Phe Arg Asn Asp Ile Ile Phe Ser Lys Ala
                 245                 250                 255    
 Gly Asp Glu Ser Asn Ile Ile Ala Ser Arg Leu Tyr Leu Val Ala Arg
             260                 265                 270        
 Thr Ser Arg Asp Lys Gln Lys Glu Ile Thr Glu Val Leu Glu Lys Leu
         275                 280                 285            
 Arg Pro Leu Ser Leu Ser Lys Ser Ile Arg Phe Ile Val Phe Asn Pro
     290                 295                 300                
 Ser Phe Val Phe Met Asp His Tyr Ser Leu Ser Val Thr Val Pro Val
 305                 310                 315                 320
 Leu Ile Ala Gly Phe Gly Val Leu Leu Val Leu Ile Leu Thr Phe Phe
                 325                 330                 335    
 Leu Val Ile His Pro Leu Gly Asn Phe Trp Leu Ile Leu Ser Val Thr
             340                 345                 350        
 Ser Ile Glu Leu Gly Val Leu Gly Leu Met Thr Leu Trp Asn Val Asp
         355                 360                 365            
 Met Asp Cys Ile Ser Ile Leu Cys Leu Ile Tyr Thr Leu Asn Phe Ala
     370                 375                 380                
 Ile Asp His Cys Ala Pro Leu Leu Phe Thr Phe Val Leu Ala Thr Glu
 385                 390                 395                 400
 His Thr Arg Thr Gln Cys Ile Lys Ser Ser Leu Gln Asp His Gly Thr
                 405                 410                 415    
 Ala Ile Leu Gln Asn Val Thr Ser Phe Leu Ile Gly Leu Val Pro Leu
             420                 425                 430        
 Leu Phe Val Pro Ser Asn Leu Thr Phe Thr Leu Phe Lys Cys Leu Leu
         435                 440                 445            
 Leu Thr Gly Gly Cys Thr Leu Leu His Cys Phe Val Ile Leu Pro Val
     450                 455                 460                
 Phe Leu Thr Phe Phe Pro Pro Ser Lys Lys His His Lys Lys Lys Lys
 465                 470                 475                 480
 Arg Ala Lys Arg Lys Glu Arg Glu Glu Ile Glu Cys Ile Glu Ile Gln
                 485                 490                 495    
 Glu Asn Pro Asp His Val Thr Thr Val
             500                 505



      <210> 528
      <211> 585
      <212> PRT
      <213> Homo sapiens


      <400> 528
 Met Asp Gln Ala Leu Leu Leu Ile His Asn Glu Leu Leu Trp Thr Asn
   1               5                  10                  15    
 Leu Thr Val Tyr Trp Lys Ser Glu Cys Cys Tyr His Cys Leu Phe Gln
              20                  25                  30        
 Val Leu Val Asn Val Pro Gln Ser Pro Lys Ala Gly Lys Pro Ser Ala
          35                  40                  45            
 Ala Ala Ala Ser Val Ser Thr Gln His Gly Ser Ile Leu Gln Leu Asn
      50                  55                  60                
 Asp Thr Leu Glu Glu Lys Glu Val Cys Arg Leu Glu Tyr Arg Phe Gly
  65                  70                  75                  80
 Glu Phe Gly Asn Tyr Ser Leu Leu Val Lys Asn Ile His Asn Gly Val
                  85                  90                  95    
 Ser Glu Ile Ala Cys Asp Leu Ala Val Asn Glu Asp Pro Val Asp Ser
             100                 105                 110        
 Asn Leu Pro Val Ser Ile Ala Phe Leu Ile Gly Leu Ala Val Ile Ile
         115                 120                 125            
 Val Ile Ser Phe Leu Arg Leu Leu Leu Ser Leu Asp Asp Phe Asn Asn
     130                 135                 140                
 Trp Ile Ser Lys Ala Ile Ser Ser Arg Glu Thr Asp Arg Leu Ile Asn
 145                 150                 155                 160
 Ser Glu Leu Gly Ser Pro Ser Arg Thr Asp Pro Leu Asp Gly Asp Val
                 165                 170                 175    
 Gln Pro Ala Thr Trp Arg Leu Ser Ala Leu Pro Pro Arg Leu Arg Ser
             180                 185                 190        
 Val Asp Thr Phe Arg Gly Ile Ala Leu Ile Leu Met Val Phe Val Asn
         195                 200                 205            
 Tyr Gly Gly Gly Lys Tyr Trp Tyr Phe Lys His Ala Ser Trp Asn Gly
     210                 215                 220                
 Leu Thr Val Ala Asp Leu Val Phe Pro Trp Phe Val Phe Ile Met Gly
 225                 230                 235                 240
 Ser Ser Ile Phe Leu Ser Met Thr Ser Ile Leu Gln Arg Gly Cys Ser
                 245                 250                 255    
 Lys Phe Arg Leu Leu Gly Lys Ile Ala Trp Arg Ser Phe Leu Leu Ile
             260                 265                 270        
 Cys Ile Gly Ile Ile Ile Val Asn Pro Asn Tyr Cys Leu Gly Pro Leu
         275                 280                 285            
 Ser Trp Asp Lys Val Arg Ile Pro Gly Val Leu Gln Arg Leu Gly Val
     290                 295                 300                
 Thr Tyr Phe Val Val Ala Val Leu Glu Leu Leu Phe Ala Lys Pro Val
 305                 310                 315                 320
 Pro Glu His Cys Ala Ser Glu Arg Ser Cys Leu Ser Leu Arg Asp Ile
                 325                 330                 335    
 Thr Ser Ser Trp Pro Gln Trp Leu Leu Ile Leu Val Leu Glu Gly Leu
             340                 345                 350        
 Trp Leu Gly Leu Thr Phe Leu Leu Pro Val Pro Gly Cys Pro Thr Gly
         355                 360                 365            
 Tyr Leu Gly Pro Gly Gly Ile Gly Asp Phe Gly Lys Tyr Pro Asn Cys
     370                 375                 380                
 Thr Gly Gly Ala Ala Gly Tyr Ile Asp Arg Leu Leu Leu Gly Asp Asp
 385                 390                 395                 400
 His Leu Tyr Gln His Pro Ser Ser Ala Val Leu Tyr His Thr Glu Val
                 405                 410                 415    
 Ala Tyr Asp Pro Glu Gly Ile Leu Gly Thr Ile Asn Ser Ile Val Met
             420                 425                 430        
 Ala Phe Leu Gly Val Gln Ala Gly Lys Ile Leu Leu Tyr Tyr Lys Ala
         435                 440                 445            
 Arg Thr Lys Asp Ile Leu Ile Arg Phe Thr Ala Trp Cys Cys Ile Leu
     450                 455                 460                
 Gly Leu Ile Ser Val Ala Leu Thr Lys Val Ser Glu Asn Glu Gly Phe
 465                 470                 475                 480
 Ile Pro Val Asn Lys Asn Leu Trp Ser Leu Ser Tyr Val Thr Thr Leu
                 485                 490                 495    
 Ser Ser Phe Ala Phe Phe Ile Leu Leu Val Leu Tyr Pro Val Val Asp
             500                 505                 510        
 Val Lys Gly Leu Trp Thr Gly Thr Pro Phe Phe Tyr Pro Gly Met Asn
         515                 520                 525            
 Ser Ile Leu Val Tyr Val Gly His Glu Val Phe Glu Asn Tyr Phe Pro
     530                 535                 540                
 Phe Gln Trp Lys Leu Lys Asp Asn Gln Ser His Lys Glu His Leu Thr
 545                 550                 555                 560
 Gln Asn Ile Val Ala Thr Ala Leu Trp Val Leu Ile Ala Tyr Ile Leu
                 565                 570                 575    
 Tyr Arg Lys Lys Ile Phe Trp Lys Ile
             580                 585



      <210> 529
      <211> 571
      <212> PRT
      <213> Homo sapiens


      <400> 529
 Met Leu Asp Ser Phe Ile Asn Ala Leu Ile Phe Leu Gly Tyr Leu Gly
   1               5                  10                  15    
 Phe His Trp Asp Gln Phe Ala Gly Tyr Arg Asn Tyr Thr Gly Trp Ala
              20                  25                  30        
 Ala Ala Arg Gln Gln Ser Val Asp Asn Glu Ile Ser Met Lys Gly Trp
          35                  40                  45            
 Lys Thr Ile Val Val Gly Leu Ile Lys Ser Gly Gln Ser Cys Arg Ser
      50                  55                  60                
 Met Ile Thr Gln Arg Glu Tyr Asp Val Met Val Thr Asn Trp Gly Asn
  65                  70                  75                  80
 Leu Glu Trp Ala Val Cys Ser Gly Ser Ser Leu Cys Pro Gly Val Phe
                  85                  90                  95    
 Arg Glu Val Ser Ala Gly Leu Gly Ala Leu Leu Leu Glu Leu Pro Arg
             100                 105                 110        
 Asp Cys Leu Gly Thr Gly Thr Ala Val Ala Leu Gly Pro Pro Leu Arg
         115                 120                 125            
 Thr Ser Pro Glu Trp Val Arg Arg Val Met Glu Gly Ala Glu Leu Ala
     130                 135                 140                
 Gly Lys Ile Leu Ser Thr Trp Leu Thr Leu Val Leu Gly Phe Ile Leu
 145                 150                 155                 160
 Leu Pro Ser Val Phe Gly Val Ser Leu Gly Ile Ser Glu Ile Tyr Met
                 165                 170                 175    
 Lys Ile Leu Val Lys Thr Leu Glu Trp Ala Thr Ile Arg Ile Glu Lys
             180                 185                 190        
 Gly Thr Pro Lys Glu Ser Ile Leu Lys Asn Ser Ala Ser Val Gly Ile
         195                 200                 205            
 Ile Gln Arg Asp Glu Ser Pro Met Glu Lys Gly Leu Ser Gly Leu Arg
     210                 215                 220                
 Gly Arg Asp Phe Glu Leu Ser Asp Val Phe Tyr Phe Ser Lys Lys Gly
 225                 230                 235                 240
 Leu Glu Ala Ile Val Glu Asp Glu Val Thr Gln Arg Phe Ser Ser Glu
                 245                 250                 255    
 Glu Leu Val Ser Trp Asn Leu Leu Thr Arg Thr Asn Val Asn Phe Gln
             260                 265                 270        
 Tyr Ile Ser Leu Arg Leu Thr Met Val Trp Val Leu Gly Val Ile Val
         275                 280                 285            
 Arg Tyr Cys Val Leu Leu Pro Leu Arg Val Thr Leu Ala Phe Ile Gly
     290                 295                 300                
 Ile Ser Leu Leu Val Ile Gly Thr Thr Leu Val Gly Gln Leu Pro Asp
 305                 310                 315                 320
 Ser Ser Leu Lys Asn Trp Leu Ser Glu Leu Val His Leu Thr Cys Cys
                 325                 330                 335    
 Arg Ile Cys Val Arg Ala Leu Ser Gly Thr Ile His Tyr His Asn Lys
             340                 345                 350        
 Gln Tyr Arg Pro Gln Lys Gly Gly Ile Cys Val Ala Asn His Thr Ser
         355                 360                 365            
 Pro Ile Asp Val Leu Ile Leu Thr Thr Asp Gly Cys Tyr Ala Met Val
     370                 375                 380                
 Gly Gln Val His Gly Gly Leu Met Gly Ile Ile Gln Arg Ala Met Val
 385                 390                 395                 400
 Lys Ala Cys Pro His Val Trp Phe Glu Arg Ser Glu Met Lys Asp Arg
                 405                 410                 415    
 His Leu Val Thr Lys Arg Leu Lys Glu His Ile Ala Asp Lys Lys Lys
             420                 425                 430        
 Leu Pro Ile Leu Ile Phe Pro Glu Gly Thr Cys Ile Asn Asn Thr Ser
         435                 440                 445            
 Val Met Met Phe Lys Lys Gly Ser Phe Glu Ile Gly Gly Thr Ile His
     450                 455                 460                
 Pro Val Ala Ile Lys Tyr Asn Pro Gln Phe Gly Asp Ala Phe Trp Asn
 465                 470                 475                 480
 Ser Ser Lys Tyr Asn Met Val Ser Tyr Leu Leu Arg Met Met Thr Ser
                 485                 490                 495    
 Trp Ala Ile Val Cys Asp Val Trp Tyr Met Pro Pro Met Thr Arg Glu
             500                 505                 510        
 Glu Gly Glu Asp Ala Val Gln Phe Ala Asn Arg Val Lys Ser Ala Ile
         515                 520                 525            
 Ala Ile Gln Gly Gly Leu Thr Glu Leu Pro Trp Asp Gly Gly Leu Lys
     530                 535                 540                
 Arg Ala Lys Val Lys Asp Ile Phe Lys Glu Glu Gln Gln Lys Asn Tyr
 545                 550                 555                 560
 Ser Lys Met Ile Val Gly Asn Gly Ser Leu Ser
                 565                 570    



      <210> 530
      <211> 253
      <212> PRT
      <213> Homo sapiens


      <400> 530
 Met Arg Pro Val Ser Trp Gly Ala Gln Ile Ser Trp Lys Gln Ala Asp
   1               5                  10                  15    
 Pro Phe Ala Ser Leu Lys Lys Val Gly Lys Asp Ser Thr Val Leu Leu
              20                  25                  30        
 Ile Cys Ile Thr Val Cys Leu Ser Tyr Leu Pro Glu Ala Gly Gln Tyr
          35                  40                  45            
 Ser Ser Phe Phe Leu Tyr Leu Arg Gln Val Ile Gly Phe Gly Ser Val
      50                  55                  60                
 Lys Ile Ala Ala Phe Ile Ala Met Val Gly Ile Leu Ser Ile Val Ala
  65                  70                  75                  80
 Gln Thr Ala Phe Leu Ser Ile Leu Met Arg Ser Leu Gly Asn Lys Asn
                  85                  90                  95    
 Thr Val Leu Leu Gly Leu Gly Phe Gln Met Leu Gln Leu Ala Trp Tyr
             100                 105                 110        
 Gly Phe Gly Ser Gln Ala Trp Met Met Trp Ala Ala Gly Thr Val Ala
         115                 120                 125            
 Ala Met Ser Ser Ile Thr Phe Pro Ala Ile Ser Ala Leu Val Ser Arg
     130                 135                 140                
 Asn Ala Glu Ser Asp Gln Gln Gly Val Ala Gln Gly Ile Ile Thr Gly
 145                 150                 155                 160
 Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr Gly Phe Ile
                 165                 170                 175    
 Phe Tyr Met Phe His Val Glu Leu Thr Glu Leu Gly Pro Lys Leu Asn
             180                 185                 190        
 Ser Asn Asn Val Pro Leu Gln Gly Ala Val Ile Pro Gly Pro Pro Phe
         195                 200                 205            
 Leu Phe Gly Ala Cys Ile Val Leu Met Ser Phe Leu Val Ala Leu Phe
     210                 215                 220                
 Ile Pro Glu Tyr Ser Lys Ala Ser Gly Val Gln Lys His Ser Asn Ser
 225                 230                 235                 240
 Ser Ser Gly Ser Leu Thr Asn Thr Pro Glu Arg Gly Ser
                 245                 250            



      <210> 531
      <211> 260
      <212> PRT
      <213> Homo sapiens


      <400> 531
 Met Ala Leu Ser Glu Ser Gly Arg Gly Lys Glu Leu Ile Pro Trp Ala
   1               5                  10                  15    
 Ile Asn Met Thr Phe Thr Val Met Asp Gln Pro Met Gly Ile Tyr Cys
              20                  25                  30        
 Pro Val Ser Arg Glu Tyr Val Lys Ser Val Tyr Pro Glu Asp Ala Thr
          35                  40                  45            
 Pro Ser Pro Val Tyr Glu Arg Asp Phe Thr Ala Val His Ile Trp Gly
      50                  55                  60                
 Pro Asn Thr Lys Arg Ser Pro Gly Asp His Arg Leu Val Leu Ala Ala
  65                  70                  75                  80
 Val Glu Thr Thr Val Leu Val Leu Ile Phe Ala Val Ser Leu Leu Gly
                  85                  90                  95    
 Asn Val Cys Ala Leu Val Leu Val Ala Arg Arg Arg Arg Arg Gly Ala
             100                 105                 110        
 Thr Ala Cys Leu Val Leu Asn Leu Phe Cys Ala Asp Leu Leu Phe Ile
         115                 120                 125            
 Ser Ala Ile Pro Leu Val Leu Ala Val Arg Trp Thr Glu Ala Trp Leu
     130                 135                 140                
 Leu Gly Pro Val Ala Cys His Leu Leu Phe Tyr Val Met Thr Leu Ser
 145                 150                 155                 160
 Gly Ser Val Thr Ile Leu Thr Leu Ala Ala Val Ser Leu Glu Arg Met
                 165                 170                 175    
 Val Cys Ile Val His Leu Gln Arg Gly Val Arg Gly Pro Gly Arg Arg
             180                 185                 190        
 Ala Arg Ala Val Leu Leu Ala Leu Ile Trp Gly Tyr Ser Ala Val Ala
         195                 200                 205            
 Ala Leu Pro Leu Cys Val Phe Phe Arg Val Val Pro Gln Arg Leu Pro
     210                 215                 220                
 Gly Ala Asp Gln Val Ser Ala Pro Leu Cys Val Pro Gly Arg Cys Pro
 225                 230                 235                 240
 Ala Gln Ala Gly Lys Arg Gly Pro Asp Gly Ser Trp Asp Glu Asp Asp
                 245                 250                 255    
 Gln Glu Gln Gln
             260



      <210> 532
      <211> 456
      <212> PRT
      <213> Homo sapiens


      <400> 532
 Met Pro Met Gln Leu Leu Leu Thr Asp Phe Ile Ile Phe Ser Ile Arg
   1               5                  10                  15    
 Phe Ile Ile Asn Ser Met Glu Ala Arg Asn Gln Thr Ala Ile Ser Lys
              20                  25                  30        
 Phe Leu Leu Leu Gly Leu Ile Glu Asp Pro Glu Leu Gln Pro Val Leu
          35                  40                  45            
 Phe Ser Leu Phe Leu Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu
      50                  55                  60                
 Leu Ile Leu Leu Ala Val Ile Ser Asp Ser His Leu His Thr Pro Met
  65                  70                  75                  80
 Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Leu Ser Thr
                  85                  90                  95    
 Thr Thr Ile Pro Lys Met Leu Val Asn Ile Gln Ala Gln Asn Arg Ser
             100                 105                 110        
 Ile Thr Tyr Ser Gly Cys Leu Thr Gln Ile Cys Phe Val Leu Phe Phe
         115                 120                 125            
 Ala Gly Leu Glu Asn Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr
     130                 135                 140                
 Val Ala Ile Cys His Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Arg
 145                 150                 155                 160
 Leu Cys Gly Leu Leu Ile Leu Leu Ser Leu Leu Thr Ser Val Val Asn
                 165                 170                 175    
 Ala Leu Leu Leu Ser Leu Met Val Leu Arg Leu Ser Phe Cys Thr Asp
             180                 185                 190        
 Leu Glu Ile Pro Leu Phe Phe Cys Glu Leu Ala Gln Val Ile Gln Leu
         195                 200                 205            
 Thr Cys Ser Asp Thr Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Ala
     210                 215                 220                
 Cys Ile Phe Gly Gly Val Pro Leu Ser Gly Ile Ile Leu Ser Tyr Thr
 225                 230                 235                 240
 Gln Ile Thr Ser Cys Val Leu Arg Met Pro Ser Ala Ser Gly Lys His
                 245                 250                 255    
 Lys Ala Val Ser Thr Cys Gly Ser His Leu Ser Ile Val Leu Leu Phe
             260                 265                 270        
 Tyr Gly Ala Gly Leu Gly Val Tyr Ile Ser Ser Val Val Thr Asp Ser
         275                 280                 285            
 Pro Arg Lys Thr Ala Val Ala Ser Val Met Tyr Ser Val Phe Pro Gln
     290                 295                 300                
 Met Val Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly
 305                 310                 315                 320
 Thr Leu Arg Lys Phe Ile Gly Arg Ile Pro Ser Leu Leu Trp Cys Ala
                 325                 330                 335    
 Ile Cys Phe Gly Phe Arg Phe Leu Asp Gly Glu Asp Arg Gly Gly Thr
             340                 345                 350        
 Gln Ile Asp Ala Asn Gly Gly Pro Ile Glu Glu Ser Asn His Arg Gln
         355                 360                 365            
 Val Gly Ala Ala Gly Gly Glu Gly Phe Leu Pro Ala Ala Cys Arg Gly
     370                 375                 380                
 Asp Leu His Asp Gly His Lys Asp Ala Ser Ile Gly Gly Gln Asp Ala
 385                 390                 395                 400
 Asp Lys Gly Arg Gly Tyr His His Pro Cys His Asn Glu Asp Glu Asp
                 405                 410                 415    
 Pro Ile His Arg Gly Val Arg Ala Arg Lys Ser Glu Asp Gly Ser Glu
             420                 425                 430        
 Val Ala Glu Val Val Arg His Leu Met Ala Ala Ala Glu Asn Glu Thr
         435                 440                 445            
 Gly His Gln Glu Asp Val Ser Glu
     450                 455    



      <210> 533
      <211> 742
      <212> PRT
      <213> Homo sapiens


      <400> 533
 Met Glu Glu Lys Glu Glu Ile Val Gly Glu Arg Met Lys Tyr Gln Asp
   1               5                  10                  15    
 Lys Ala Ala Ala Ser Thr Ser Ala Ala Lys Gln Arg Asn Pro Glu Thr
              20                  25                  30        
 Glu Thr His Gly Pro Gln Asn Thr Ala Ala Ser Thr Leu Asn Thr Asp
          35                  40                  45            
 Ala Ser Ser Val Thr Val Leu Thr Ala Ser Phe Thr Glu Thr Ser Thr
      50                  55                  60                
 Val Ser Leu Asp Asn Glu Thr Thr Val Lys Thr Ser Asp Ile Leu Asp
  65                  70                  75                  80
 Ala Arg Lys Thr Asn Glu Leu Pro Ser Asp Ser Ser Ser Ser Ser Asp
                  85                  90                  95    
 Leu Ile Asn Thr Ser Ile Ala Ser Ser Thr Met Asp Val Thr Lys Thr
             100                 105                 110        
 Ala Ser Ile Ser Pro Thr Ser Ile Ser Gly Met Thr Ala Ser Ser Ser
         115                 120                 125            
 Pro Ser Leu Phe Ser Ser Asp Arg Pro Gln Val Pro Thr Ser Thr Thr
     130                 135                 140                
 Glu Thr Asn Thr Ala Thr Ser Pro Ser Val Ser Ser Asn Thr Tyr Ser
 145                 150                 155                 160
 Leu Asp Gly Gly Ser Asn Val Gly Gly Thr Pro Ser Thr Leu Pro Pro
                 165                 170                 175    
 Phe Thr Ile Thr His Pro Val Glu Thr Ser Ser Ala Leu Leu Ala Trp
             180                 185                 190        
 Ser Arg Pro Val Arg Thr Phe Ser Thr Met Val Ser Thr Asp Thr Ala
         195                 200                 205            
 Ser Gly Glu Asn Pro Thr Ser Ser Asn Ser Val Val Thr Ser Val Pro
     210                 215                 220                
 Ala Pro Gly Thr Trp Thr Ser Val Gly Ser Thr Thr Asp Leu Pro Ala
 225                 230                 235                 240
 Met Gly Phe Leu Lys Thr Ser Pro Ala Gly Glu Ala His Ser Leu Leu
                 245                 250                 255    
 Ala Ser Thr Ile Glu Pro Ala Thr Ala Phe Thr Pro His Leu Ser Ala
             260                 265                 270        
 Ala Val Val Thr Gly Ser Ser Ala Thr Ser Glu Ala Ser Leu Leu Thr
         275                 280                 285            
 Thr Ser Glu Ser Lys Ala Ile His Ser Ser Pro Gln Thr Pro Thr Thr
     290                 295                 300                
 Pro Thr Ser Gly Ala Asn Trp Glu Thr Ser Ala Thr Pro Glu Ser Leu
 305                 310                 315                 320
 Leu Val Val Thr Glu Thr Ser Asp Thr Thr Leu Thr Ser Lys Ile Leu
                 325                 330                 335    
 Val Thr Asp Thr Ile Leu Phe Ser Thr Val Ser Thr Pro Pro Ser Lys
             340                 345                 350        
 Phe Pro Ser Thr Gly Thr Leu Ser Gly Ala Ser Phe Pro Thr Leu Leu
         355                 360                 365            
 Pro Asp Thr Pro Ala Ile Pro Leu Thr Ala Thr Glu Pro Thr Ser Ser
     370                 375                 380                
 Leu Ala Thr Ser Phe Asp Ser Thr Pro Leu Val Thr Ile Ala Ser Asp
 385                 390                 395                 400
 Ser Leu Gly Thr Val Pro Glu Thr Thr Leu Thr Met Ser Glu Thr Ser
                 405                 410                 415    
 Asn Gly Asp Ala Leu Val Leu Lys Thr Val Ser Asn Pro Asp Arg Ser
             420                 425                 430        
 Ile Pro Gly Ile Thr Ile Gln Gly Val Thr Glu Ser Pro Leu His Pro
         435                 440                 445            
 Ser Ser Thr Ser Pro Ser Lys Ile Val Ala Pro Arg Asn Thr Thr Tyr
     450                 455                 460                
 Glu Gly Ser Ile Thr Val Ala Leu Ser Thr Leu Pro Ala Gly Thr Thr
 465                 470                 475                 480
 Gly Ser Leu Val Phe Ser Gln Ser Ser Glu Asn Ser Glu Thr Thr Ala
                 485                 490                 495    
 Leu Val Asp Ser Ser Ala Gly Leu Glu Arg Ala Ser Val Met Pro Leu
             500                 505                 510        
 Thr Thr Gly Ser Gln Gly Met Ala Ser Ser Gly Gly Ile Arg Ser Gly
         515                 520                 525            
 Ser Thr His Ser Thr Gly Thr Lys Thr Phe Ser Ser Leu Pro Leu Thr
     530                 535                 540                
 Met Asn Pro Ala Thr Asp Gly Thr Leu Val Thr Thr Ile Lys Met Ser
 545                 550                 555                 560
 Ser Gln Ala Ala Gln Gly Asn Ser Thr Trp Pro Ala Pro Ala Glu Glu
                 565                 570                 575    
 Thr Gly Thr Ser Pro Ala Val Leu Gly Asn Leu Leu Ile Ile Leu Ala
             580                 585                 590        
 Ile Ser Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala
         595                 600                 605            
 Asn Leu Ser Leu Ile Asp Phe Cys Leu Ala Thr Asn Thr Ile Pro Lys
     610                 615                 620                
 Met Leu Ala Gln Ser Gln Gly Ala Arg Leu Leu Ala Pro Ala Ala Cys
 625                 630                 635                 640
 Ala Ser Lys Ile Ala Glu Ala Gly Arg Glu Met Ala Gly Arg His Val
                 645                 650                 655    
 Pro Trp Pro Glu Asp Thr Tyr Pro Gly Arg Lys Thr Ser Thr Leu Ala
             660                 665                 670        
 Gly Arg His Leu Pro Trp Pro Glu Asp Thr Tyr Pro Gly Arg Lys Thr
         675                 680                 685            
 Ser Thr Leu Ala Gly Arg His Arg Pro Trp Pro Glu Asp Ser Tyr Leu
     690                 695                 700                
 Gly Arg Lys Thr Pro Ala Leu Ala Gly Arg His Val Pro Trp Leu Glu
 705                 710                 715                 720
 Asp Ile Tyr Pro Gly Arg Lys Thr His Ala Pro Glu Asp Gln Glu Thr
                 725                 730                 735    
 Gly His Pro Gly Thr Met
             740        



      <210> 534
      <211> 581
      <212> PRT
      <213> Homo sapiens


      <400> 534
 Met Val Tyr Glu Thr Lys Arg Cys Asn Glu Thr Arg Glu Asn Ala Phe
   1               5                  10                  15    
 Leu Glu Ala Gly Asn Asn Thr Met Asp Ile Asn Cys Ala Asp Ala Leu
              20                  25                  30        
 Lys Gly Asn Leu Arg Asp Trp Lys Thr Asn Val Leu Tyr Lys Val Gln
          35                  40                  45            
 Arg Val Asn Met Leu Gly Leu Leu Phe Gln Met Thr Phe Val Ile Thr
      50                  55                  60                
 Thr Gln Leu Cys His Gln Ser Val Lys Ala Ala Ile Asp Asp Val Ser
  65                  70                  75                  80
 Val Lys Asp Lys Arg Lys Gly Met Gln Glu Val Lys Leu Asn Ser Tyr
                  85                  90                  95    
 Val Val Ser Gly Thr Val Gly Leu Lys Glu Lys Ile Ser Leu Ser Glu
             100                 105                 110        
 Pro Val Phe Leu Thr Phe Arg His Asn Gln Pro Gly Asp Lys Arg Thr
         115                 120                 125            
 Lys His Ile Cys Val Tyr Trp Glu Gly Ser Glu Gly Gly His Trp Ser
     130                 135                 140                
 Thr Glu Gly Cys Ser His Val His Ser Asn Gly Ser Tyr Thr Lys Cys
 145                 150                 155                 160
 Lys Cys Phe His Leu Ser Ser Phe Ala Val Leu Val Ala Leu Ala Pro
                 165                 170                 175    
 Lys Glu Asp Pro Val Leu Thr Val Ile Thr Gln Val Gly Leu Thr Ile
             180                 185                 190        
 Ser Leu Leu Cys Leu Phe Leu Ala Ile Leu Thr Phe Leu Leu Cys Arg
         195                 200                 205            
 Pro Ile Gln Asn Thr Ser Thr Ser Leu His Leu Glu Leu Ser Leu Cys
     210                 215                 220                
 Leu Phe Leu Ala His Leu Leu Phe Leu Thr Gly Ile Asn Arg Thr Glu
 225                 230                 235                 240
 Pro Glu Val Leu Cys Ser Ile Ile Ala Gly Leu Leu His Phe Leu Tyr
                 245                 250                 255    
 Leu Ala Cys Phe Thr Trp Met Leu Leu Glu Gly Leu His Leu Phe Leu
             260                 265                 270        
 Thr Val Arg Asn Leu Lys Val Ala Asn Tyr Thr Ser Thr Gly Arg Phe
         275                 280                 285            
 Lys Lys Arg Phe Met Tyr Pro Val Gly Tyr Gly Ile Pro Ala Val Ile
     290                 295                 300                
 Ile Ala Val Ser Ala Ile Val Gly Pro Gln Asn Tyr Gly Thr Phe Thr
 305                 310                 315                 320
 His Cys Trp Leu Lys Leu Asp Lys Gly Phe Ile Trp Ser Phe Met Gly
                 325                 330                 335    
 Pro Val Ala Val Ile Ile Leu Ile Asn Leu Val Phe Tyr Phe Gln Val
             340                 345                 350        
 Leu Trp Ile Leu Arg Ser Lys Leu Ser Ser Leu Asn Lys Glu Val Ser
         355                 360                 365            
 Thr Ile Gln Asp Thr Arg Val Met Thr Phe Lys Ala Ile Ser Gln Leu
     370                 375                 380                
 Phe Ile Leu Gly Cys Ser Trp Gly Leu Gly Phe Phe Met Val Glu Glu
 385                 390                 395                 400
 Val Gly Lys Thr Ile Gly Ser Ile Ile Ala Tyr Ser Phe Thr Ile Ile
                 405                 410                 415    
 Asn Thr Leu Gln Gly Val Leu Leu Phe Val Val His Cys Leu Leu Asn
             420                 425                 430        
 Arg Gln Ile Asn Ser Leu Leu Leu Thr Trp Thr Leu Trp Ile Leu Arg
         435                 440                 445            
 Gln Arg Leu Ser Ser Val Asn Ala Glu Val Ser Thr Leu Lys Asp Thr
     450                 455                 460                
 Arg Leu Leu Thr Phe Lys Ala Phe Ala Gln Leu Phe Ile Leu Gly Cys
 465                 470                 475                 480
 Ser Trp Val Leu Gly Ile Phe Gln Ile Gly Pro Val Ala Gly Val Met
                 485                 490                 495    
 Ala Tyr Leu Phe Thr Ile Ile Asn Ser Leu Gln Gly Ala Phe Ile Phe
             500                 505                 510        
 Leu Ile His Cys Leu Leu Asn Gly Gln Val Arg Glu Glu Tyr Lys Arg
         515                 520                 525            
 Trp Ile Thr Gly Lys Thr Lys Pro Ser Ser Gln Ser Gln Thr Ser Arg
     530                 535                 540                
 Ile Leu Leu Ser Ser Met Pro Ser Ala Ser Lys Thr Ser Ile Ile Gly
 545                 550                 555                 560
 Tyr Ile Ala Pro Thr Met Val Gly Gln Cys Val Thr Phe Gln Met Glu
                 565                 570                 575    
 His Phe Leu Phe Ser
             580    



      <210> 535
      <211> 855
      <212> PRT
      <213> Homo sapiens


      <400> 535
 Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys
   1               5                  10                  15    
 Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala
              20                  25                  30        
 Glu Glu Pro Ser Phe Leu Gln Pro Leu Arg Arg Gln Ala Phe Leu Arg
          35                  40                  45            
 Ser Val Ser Met Pro Ala Glu Thr Ala His Ile Ser Ser Pro His His
      50                  55                  60                
 Glu Leu Arg Arg Pro Val Leu Gln Arg Gln Thr Ser Ile Thr Gln Thr
  65                  70                  75                  80
 Ile Arg Arg Gly Thr Ala Asp Trp Phe Gly Val Ser Lys Asp Ser Asp
                  85                  90                  95    
 Ser Thr Gln Lys Trp Gln Arg Lys Ser Ile Arg His Cys Ser Gln Arg
             100                 105                 110        
 Tyr Gly Lys Leu Lys Pro Gln Val Leu Arg Glu Leu Asp Leu Pro Ser
         115                 120                 125            
 Gln Asp Asn Val Ser Leu Thr Ser Thr Glu Thr Pro Pro Pro Leu Tyr
     130                 135                 140                
 Val Gly Pro Cys Gln Leu Gly Met Gln Lys Ile Ile Asp Pro Leu Ala
 145                 150                 155                 160
 Arg Gly Arg Ala Phe Arg Val Ala Asp Asp Thr Ala Glu Gly Leu Ser
                 165                 170                 175    
 Ala Pro His Thr Pro Val Thr Pro Gly Ala Ala Ser Leu Cys Ser Phe
             180                 185                 190        
 Ser Ser Ser Arg Ser Gly Phe His Arg Leu Pro Arg Arg Arg Lys Arg
         195                 200                 205            
 Glu Ser Val Ala Lys Met Ser Phe Arg Ala Ala Ala Ala Leu Met Lys
     210                 215                 220                
 Gly Arg Ser Val Arg Asp Gly Thr Phe Arg Arg Ala Gln Arg Arg Ser
 225                 230                 235                 240
 Phe Thr Pro Ala Ser Phe Leu Glu Glu Asp Thr Thr Asp Phe Pro Asp
                 245                 250                 255    
 Glu Leu Asp Thr Ser Phe Phe Ala Arg Glu Gly Ile Leu His Glu Glu
             260                 265                 270        
 Leu Ser Thr Tyr Pro Asp Glu Val Phe Glu Ser Pro Ser Glu Ala Ala
         275                 280                 285            
 Leu Lys Asp Trp Glu Lys Ala Pro Glu Gln Ala Asp Leu Thr Gly Gly
     290                 295                 300                
 Ala Leu Asp Arg Ser Glu Leu Glu Arg Ser His Leu Met Leu Pro Leu
 305                 310                 315                 320
 Glu Arg Gly Trp Arg Lys Gln Lys Glu Gly Ala Ala Ala Pro Gln Pro
                 325                 330                 335    
 Lys Val Arg Leu Arg Gln Glu Val Val Ser Thr Ala Gly Pro Arg Arg
             340                 345                 350        
 Gly Gln Arg Ile Ala Val Pro Val Arg Lys Leu Phe Ala Arg Glu Lys
         355                 360                 365            
 Arg Pro Tyr Gly Leu Gly Met Val Gly Arg Leu Thr Asn Arg Thr Tyr
     370                 375                 380                
 Arg Lys Arg Ile Asp Ser Phe Val Lys Arg Gln Ile Glu Asp Met Asp
 385                 390                 395                 400
 Asp His Arg Pro Phe Phe Thr Tyr Trp Leu Thr Phe Val His Ser Leu
                 405                 410                 415    
 Val Ala Ile Leu Ala Val Cys Ile Tyr Gly Ile Ala Pro Val Gly Phe
             420                 425                 430        
 Ser Gln His Glu Thr Val Asp Ser Val Leu Arg Asn Arg Gly Val Tyr
         435                 440                 445            
 Glu Asn Val Lys Tyr Val Gln Gln Glu Asn Phe Trp Ile Gly Pro Ser
     450                 455                 460                
 Ser Glu Ala Leu Ile His Leu Gly Ala Lys Phe Ser Pro Cys Met Arg
 465                 470                 475                 480
 Gln Asp Pro Gln Val His Ser Phe Ile Arg Ser Ala Arg Glu Arg Glu
                 485                 490                 495    
 Lys His Ser Ala Cys Cys Val Arg Asn Asp Arg Ser Gly Cys Val Gln
             500                 505                 510        
 Thr Ser Glu Glu Glu Cys Ser Ser Thr Leu Ala Val Trp Val Lys Trp
         515                 520                 525            
 Pro Ile His Pro Ser Ala Pro Glu Leu Ala Gly His Lys Arg Gln Phe
     530                 535                 540                
 Gly Ser Val Cys His Gln Asp Pro Arg Val Cys Asp Glu Pro Ser Ser
 545                 550                 555                 560
 Glu Asp Pro His Glu Trp Pro Glu Asp Ile Thr Lys Trp Pro Ile Cys
                 565                 570                 575    
 Thr Lys Asn Ser Ala Gly Asn His Thr Asn His Pro His Met Asp Cys
             580                 585                 590        
 Val Ile Thr Gly Arg Pro Cys Cys Ile Gly Thr Lys Gly Arg Cys Glu
         595                 600                 605            
 Ile Thr Ser Arg Glu Tyr Cys Asp Phe Met Arg Gly Tyr Phe His Glu
     610                 615                 620                
 Glu Ala Thr Leu Cys Ser Gln Val His Cys Met Asp Asp Val Cys Gly
 625                 630                 635                 640
 Leu Leu Pro Phe Leu Asn Pro Glu Val Pro Asp Gln Phe Tyr Arg Leu
                 645                 650                 655    
 Trp Leu Ser Leu Phe Leu His Ala Gly Ile Leu His Cys Leu Val Ser
             660                 665                 670        
 Ile Cys Phe Gln Met Thr Val Leu Arg Asp Leu Glu Lys Leu Ala Gly
         675                 680                 685            
 Trp His Arg Ile Ala Ile Ile Tyr Leu Leu Ser Gly Val Thr Gly Asn
     690                 695                 700                
 Leu Ala Ser Ala Ile Phe Leu Pro Tyr Arg Ala Glu Val Gly Pro Ala
 705                 710                 715                 720
 Gly Ser Gln Phe Gly Ile Leu Ala Cys Leu Phe Val Glu Leu Phe Gln
                 725                 730                 735    
 Ser Trp Gln Ile Leu Ala Arg Pro Trp Arg Ala Phe Phe Lys Leu Leu
             740                 745                 750        
 Ala Val Val Leu Phe Leu Phe Thr Phe Gly Leu Leu Pro Trp Ile Asp
         755                 760                 765            
 Asn Phe Ala His Ile Ser Gly Phe Ile Ser Gly Leu Phe Leu Ser Phe
     770                 775                 780                
 Ala Phe Leu Pro Tyr Ile Ser Phe Gly Lys Phe Asp Leu Tyr Arg Lys
 785                 790                 795                 800
 Arg Cys Gln Ile Ile Ile Phe Gln Val Val Phe Leu Gly Leu Leu Ala
                 805                 810                 815    
 Gly Leu Val Val Leu Phe Tyr Val Tyr Pro Val Arg Cys Glu Trp Cys
             820                 825                 830        
 Glu Phe Leu Thr Cys Ile Pro Phe Thr Asp Lys Phe Cys Glu Lys Tyr
         835                 840                 845            
 Glu Leu Asp Ala Gln Leu His
     850                 855



      <210> 536
      <211> 878
      <212> PRT
      <213> Homo sapiens


      <400> 536
 Met Ser Glu Ala Arg Arg Asp Ser Thr Ser Ser Leu Gln Arg Lys Lys
   1               5                  10                  15    
 Pro Pro Trp Leu Lys Leu Asp Ile Pro Ser Ala Val Pro Leu Thr Ala
              20                  25                  30        
 Glu Glu Pro Ser Phe Leu Gln Val Gly Pro Gly Leu Gln Gly Leu Trp
          35                  40                  45            
 Val Pro Pro Val Gln Tyr Pro His His Asp Pro Val Ala Gln Pro Leu
      50                  55                  60                
 Arg Arg Gln Ala Phe Leu Arg Ser Val Ser Met Pro Ala Glu Thr Ala
  65                  70                  75                  80
 His Ile Ser Ser Pro His His Glu Leu Arg Arg Pro Val Leu Gln Arg
                  85                  90                  95    
 Gln Thr Ser Ile Thr Gln Thr Ile Arg Arg Gly Thr Ala Asp Trp Phe
             100                 105                 110        
 Gly Val Ser Lys Asp Ser Asp Ser Thr Gln Lys Trp Gln Arg Lys Ser
         115                 120                 125            
 Ile Arg His Cys Ser Gln Arg Tyr Gly Lys Leu Lys Pro Gln Val Leu
     130                 135                 140                
 Arg Glu Leu Asp Leu Pro Ser Gln Asp Asn Val Ser Leu Thr Ser Thr
 145                 150                 155                 160
 Glu Thr Pro Pro Pro Leu Tyr Val Gly Pro Cys Gln Leu Gly Met Gln
                 165                 170                 175    
 Lys Ile Ile Asp Pro Leu Ala Arg Gly Arg Ala Phe Arg Val Ala Asp
             180                 185                 190        
 Asp Thr Ala Glu Gly Leu Ser Ala Pro His Thr Pro Val Thr Pro Gly
         195                 200                 205            
 Ala Ala Ser Leu Cys Ser Phe Ser Ser Ser Arg Ser Gly Phe His Arg
     210                 215                 220                
 Leu Pro Arg Arg Arg Lys Arg Glu Ser Val Ala Lys Met Ser Phe Arg
 225                 230                 235                 240
 Ala Ala Ala Ala Leu Met Lys Gly Arg Ser Val Arg Asp Gly Thr Phe
                 245                 250                 255    
 Arg Arg Ala Gln Arg Arg Ser Phe Thr Pro Ala Ser Phe Leu Glu Glu
             260                 265                 270        
 Asp Thr Thr Asp Phe Pro Asp Glu Leu Asp Thr Ser Phe Phe Ala Arg
         275                 280                 285            
 Glu Gly Ile Leu His Glu Glu Leu Ser Thr Tyr Pro Asp Glu Val Phe
     290                 295                 300                
 Glu Ser Pro Ser Glu Ala Ala Leu Lys Asp Trp Glu Lys Ala Pro Glu
 305                 310                 315                 320
 Gln Ala Asp Leu Thr Gly Gly Ala Leu Asp Arg Ser Glu Leu Glu Arg
                 325                 330                 335    
 Ser His Leu Met Leu Pro Leu Glu Arg Gly Trp Arg Lys Gln Lys Glu
             340                 345                 350        
 Gly Ala Ala Ala Pro Gln Pro Lys Val Arg Leu Arg Gln Glu Val Val
         355                 360                 365            
 Ser Thr Ala Gly Pro Arg Arg Gly Gln Arg Ile Ala Val Pro Val Arg
     370                 375                 380                
 Lys Leu Phe Ala Arg Glu Lys Arg Pro Tyr Gly Leu Gly Met Val Gly
 385                 390                 395                 400
 Arg Leu Thr Asn Arg Thr Tyr Arg Lys Arg Ile Asp Ser Phe Val Lys
                 405                 410                 415    
 Arg Gln Ile Glu Asp Met Asp Asp His Arg Pro Phe Phe Thr Tyr Trp
             420                 425                 430        
 Leu Thr Phe Val His Ser Leu Val Ala Ile Leu Ala Val Cys Ile Tyr
         435                 440                 445            
 Gly Ile Ala Pro Val Gly Phe Ser Gln His Glu Thr Val Asp Ser Val
     450                 455                 460                
 Leu Arg Asn Arg Gly Val Tyr Glu Asn Val Lys Tyr Val Gln Gln Glu
 465                 470                 475                 480
 Asn Phe Trp Ile Gly Pro Ser Ser Glu Ala Leu Ile His Leu Gly Ala
                 485                 490                 495    
 Lys Phe Ser Pro Cys Met Arg Gln Asp Pro Gln Val His Ser Phe Ile
             500                 505                 510        
 Arg Ser Ala Arg Glu Arg Glu Lys His Ser Ala Cys Cys Val Arg Asn
         515                 520                 525            
 Asp Arg Ser Gly Cys Val Gln Thr Ser Glu Glu Glu Cys Ser Ser Thr
     530                 535                 540                
 Leu Ala Val Trp Val Lys Trp Pro Ile His Pro Ser Ala Pro Glu Leu
 545                 550                 555                 560
 Ala Gly His Lys Arg Gln Phe Gly Ser Val Cys His Gln Asp Pro Arg
                 565                 570                 575    
 Val Cys Asp Glu Pro Ser Ser Glu Asp Pro His Glu Trp Pro Glu Asp
             580                 585                 590        
 Ile Thr Lys Trp Pro Ile Cys Thr Lys Asn Ser Ala Gly Asn His Thr
         595                 600                 605            
 Asn His Pro His Met Asp Cys Val Ile Thr Gly Arg Pro Cys Cys Ile
     610                 615                 620                
 Gly Thr Lys Gly Arg Cys Glu Ile Thr Ser Arg Glu Tyr Cys Asp Phe
 625                 630                 635                 640
 Met Arg Gly Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val His
                 645                 650                 655    
 Cys Met Asp Asp Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu Val
             660                 665                 670        
 Pro Asp Gln Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala Gly
         675                 680                 685            
 Ile Leu His Cys Leu Val Ser Ile Cys Phe Gln Met Thr Val Leu Arg
     690                 695                 700                
 Asp Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Tyr Leu
 705                 710                 715                 720
 Leu Ser Gly Val Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro Tyr
                 725                 730                 735    
 Arg Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Ile Leu Ala Cys
             740                 745                 750        
 Leu Phe Val Glu Leu Phe Gln Ser Trp Gln Ile Leu Ala Arg Pro Trp
         755                 760                 765            
 Arg Ala Phe Phe Lys Leu Leu Ala Val Val Leu Phe Leu Phe Thr Phe
     770                 775                 780                
 Gly Leu Leu Pro Trp Ile Asp Asn Phe Ala His Ile Ser Gly Phe Ile
 785                 790                 795                 800
 Ser Gly Leu Phe Leu Ser Phe Ala Phe Leu Pro Tyr Ile Ser Phe Gly
                 805                 810                 815    
 Lys Phe Asp Leu Tyr Arg Lys Arg Cys Gln Ile Ile Ile Phe Gln Val
             820                 825                 830        
 Val Phe Leu Gly Leu Leu Ala Gly Leu Val Val Leu Phe Tyr Val Tyr
         835                 840                 845            
 Pro Val Arg Cys Glu Trp Cys Glu Phe Leu Thr Cys Ile Pro Phe Thr
     850                 855                 860                
 Asp Lys Phe Cys Glu Lys Tyr Glu Leu Asp Ala Gln Leu His
 865                 870                 875            



      <210> 537
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 537
 Met Asp Leu Ala Gln Pro Ser Gln Pro Val Asp Glu Leu Glu Leu Ser
   1               5                  10                  15    
 Val Leu Glu Arg Gln Pro Glu Glu Asn Thr Pro Leu Asn Gly Ala Asp
              20                  25                  30        
 Lys Val Phe Pro Ser Leu Asp Glu Glu Val Pro Pro Ala Glu Ala Asn
          35                  40                  45            
 Lys Glu Ser Pro Trp Ser Ser Cys Asn Lys Asn Val Val Gly Arg Cys
      50                  55                  60                
 Lys Leu Trp Met Ile Ile Thr Ser Ile Phe Leu Gly Val Ile Thr Val
  65                  70                  75                  80
 Ile Ile Ile Gly Leu Cys Leu Ala Ala Val Thr Tyr Val Asp Glu Asp
                  85                  90                  95    
 Glu Asn Glu Ile Leu Glu Leu Ser Ser Asn Lys Thr Phe Phe Ile Met
             100                 105                 110        
 Leu Lys Ile Pro Glu Glu Cys Val Ala Glu Glu Glu Leu Pro His Leu
         115                 120                 125            
 Leu Thr Glu Arg Leu Thr Asp Val Tyr Ser Thr Ser Pro Ser Leu Ser
     130                 135                 140                
 Arg Tyr Phe Thr Ser Val Glu Ile Val Asp Phe Ser Gly Glu Asn Ala
 145                 150                 155                 160
 Thr Val Thr Tyr Asp Leu Gln Phe Gly Val Pro Ser Asp Asp Glu Asn
                 165                 170                 175    
 Phe Met Lys Tyr Met Met Ser Glu Glu Leu Val Leu Gly Ile Leu Leu
             180                 185                 190        
 Gln Asp Phe Arg Asp Gln Asn Ile Pro Gly Cys Glu Ser Leu Gly Leu
         195                 200                 205            
 Asp Pro Thr Ser Leu Leu Leu Tyr Glu
     210                 215        



      <210> 538
      <211> 312
      <212> PRT
      <213> Homo sapiens


      <400> 538
 Met Glu Pro Leu Asn Arg Thr Glu Val Ser Glu Phe Phe Leu Lys Gly
   1               5                  10                  15    
 Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser
              20                  25                  30        
 Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Met Ala Val
          35                  40                  45            
 Ser Val Leu Asp Ile His Leu His Thr Pro Val Tyr Phe Phe Leu Gly
      50                  55                  60                
 Asn Leu Ser Thr Leu Asp Ile Cys Tyr Thr Pro Thr Phe Val Pro Leu
  65                  70                  75                  80
 Met Leu Val His Leu Leu Ser Ser Arg Lys Thr Ile Ser Phe Ala Val
                  85                  90                  95    
 Cys Ala Ile Gln Met Cys Leu Ser Leu Ser Thr Gly Ser Thr Glu Cys
             100                 105                 110        
 Leu Leu Leu Ala Ile Thr Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gln
         115                 120                 125            
 Pro Leu Arg Tyr His Val Leu Met Ser His Arg Leu Cys Val Leu Leu
     130                 135                 140                
 Met Gly Ala Ala Trp Val Leu Cys Leu Leu Lys Ser Val Thr Glu Met
 145                 150                 155                 160
 Val Ile Ser Met Arg Leu Pro Phe Cys Gly His His Val Val Ser His
                 165                 170                 175    
 Phe Thr Cys Lys Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asn Thr
             180                 185                 190        
 Ser Val Ser Glu Asp Phe Leu Leu Ala Gly Ser Ile Leu Leu Leu Pro
         195                 200                 205            
 Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Leu Leu Ile Leu Ala Thr
     210                 215                 220                
 Ile Leu Arg Val Pro Ser Ala Ala Arg Cys Cys Lys Ala Phe Ser Thr
 225                 230                 235                 240
 Cys Leu Ala His Leu Ala Val Val Leu Leu Phe Tyr Gly Thr Ile Ile
                 245                 250                 255    
 Phe Met Tyr Leu Lys Pro Lys Ser Lys Glu Ala His Ile Ser Asp Glu
             260                 265                 270        
 Val Phe Thr Val Leu Tyr Ala Met Val Thr Thr Met Leu Asn Pro Thr
         275                 280                 285            
 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ala Arg Lys Val
     290                 295                 300                
 Trp Gly Arg Ser Arg Ala Ser Arg
 305                 310        



      <210> 539
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 539
 Met Asp Ala Gly Lys Ala Gly Gln Thr Leu Lys Thr His Cys Ser Ala
   1               5                  10                  15    
 Gln Arg Pro Asp Val Cys Arg Trp Leu Ser Pro Phe Ile Leu Ser Cys
              20                  25                  30        
 Cys Val Tyr Phe Cys Leu Trp Ile Pro Glu Asp Gln Leu Ser Trp Phe
          35                  40                  45            
 Ala Ala Leu Val Lys Cys Leu Pro Val Leu Cys Leu Ala Gly Phe Leu
      50                  55                  60                
 Trp Val Met Ser Pro Ser Gly Gly Tyr Thr Gln Leu Leu Gln Gly Ala
  65                  70                  75                  80
 Leu Val Cys Ser Ala Val Gly Asp Ala Cys Leu Ile Trp Pro Ala Ala
                  85                  90                  95    
 Phe Val Pro Gly Met Ala Ala Phe Ala Thr Ala His Leu Leu Tyr Val
             100                 105                 110        
 Trp Ala Phe Gly Phe Ser Pro Leu Gln Pro Gly Leu Leu Leu Leu Ile
         115                 120                 125            
 Ile Leu Ala Pro Gly Pro Tyr Leu Ser Leu Val Leu Gln His Leu Glu
     130                 135                 140                
 Pro Asp Met Val Leu Pro Val Ala Ala Tyr Gly Leu Ile Leu Met Ala
 145                 150                 155                 160
 Met Leu Trp Arg Gly Leu Ala Gln Gly Gly Ser Ala Gly Trp Gly Ala
                 165                 170                 175    
 Leu Leu Phe Thr Leu Ser Asp Gly Val Leu Ala Trp Asp Thr Phe Ala
             180                 185                 190        
 Gln Pro Leu Pro His Ala Arg Leu Val Ile Met Thr Thr Tyr Tyr Ala
         195                 200                 205            
 Ala Gln Leu Leu Ile Thr Leu Ser Ala Leu Arg Ser Pro Val Pro Lys
     210                 215                 220                
 Thr Asp
 225    



      <210> 540
      <211> 118
      <212> PRT
      <213> Homo sapiens


      <400> 540
 Met Glu Asp Phe Ala Thr Arg Thr Tyr Gly Thr Ser Gly Leu Asp Asn
   1               5                  10                  15    
 Arg Pro Leu Phe Gly Glu Thr Ser Ala Lys Asp Arg Ile Ile Asn Leu
              20                  25                  30        
 Val Val Gly Ser Leu Thr Ser Leu Leu Ile Leu Val Thr Leu Ile Ser
          35                  40                  45            
 Ala Phe Val Phe Pro Gln Leu Pro Pro Lys Pro Leu Asn Ile Phe Phe
      50                  55                  60                
 Ala Val Cys Ile Ser Leu Ser Ser Ile Thr Ala Cys Ile Leu Ile Tyr
  65                  70                  75                  80
 Trp Tyr Arg Gln Gly Asp Leu Glu Pro Lys Phe Arg Lys Leu Ile Tyr
                  85                  90                  95    
 Tyr Ile Ile Phe Ser Ile Ile Met Leu Cys Ile Cys Ala Asn Leu Tyr
             100                 105                 110        
 Phe His Asp Val Gly Arg
         115            



      <210> 541
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 541
 Met Tyr Arg Thr Leu Cys Cys Val Gln Trp Arg Asn Leu Pro Gly Pro
   1               5                  10                  15    
 Gly Glu Ser Ser Asp Ser Ala Ser Arg Leu Cys Phe Ala Ser Ser Asn
              20                  25                  30        
 Val Glu Leu Thr Ser Gly Pro Gln Ser Pro Ala Gly Leu Ser Val Arg
          35                  40                  45            
 His Ala Arg Val Val Glu Met Gly Pro Pro Gly Pro Pro Ala Val His
      50                  55                  60                
 Trp Ala Glu Thr Ser Gly Lys Pro Ala Ala Gly Ala Leu Pro Gly Gln
  65                  70                  75                  80
 Leu Pro Pro Ala Gln Cys Ser Gln Thr Ser Pro Ser Gly Lys Gln Ser
                  85                  90                  95    
 Val Gln Gln Met Leu Cys Glu Ile Leu Gly Phe Ser Leu Phe Leu Phe
             100                 105                 110        
 Cys Phe Val Phe Glu Arg Lys Lys Lys Ile Gln Leu Thr Ser Leu Phe
         115                 120                 125            
 Cys Lys Trp Val Ser Phe Leu Cys Ile Lys Ser Trp Trp Ser Leu Val
     130                 135                 140                
 Phe Thr Cys Ser Cys Cys Val Ile Leu Arg Cys Tyr
 145                 150                 155    



      <210> 542
      <211> 777
      <212> PRT
      <213> Homo sapiens


      <400> 542
 Met Ser Thr Val Arg Met Thr Leu Arg Ile Thr Glu Asn Thr Pro Ile
   1               5                  10                  15    
 Ser Ser Phe Ser Thr Ser Ile Val Val Ile Pro Glu Thr Pro Thr Thr
              20                  25                  30        
 Gln Ala Pro Pro Val Leu Met Ser Ala Thr Gly Thr Gln Thr Ser Pro
          35                  40                  45            
 Val Pro Thr Thr Val Thr Phe Gly Ser Met Asp Ser Ser Thr Ser Thr
      50                  55                  60                
 Leu His Thr Leu Thr Pro Ser Thr Ala Leu Ser Lys Ile Met Ser Thr
  65                  70                  75                  80
 Ser Gln Phe Pro Ile Pro Ser Thr His Ser Ser Thr Leu Gln Thr Thr
                  85                  90                  95    
 Pro Ser Ile Pro Ser Leu Gln Thr Ser Leu Thr Ser Thr Ser Glu Phe
             100                 105                 110        
 Thr Thr Glu Ser Phe Thr Arg Gly Ser Thr Ser Thr Asn Ala Ile Leu
         115                 120                 125            
 Thr Ser Phe Ser Thr Ile Ile Trp Ser Ser Thr Pro Thr Ile Ile Met
     130                 135                 140                
 Ser Ser Ser Pro Ser Ser Ala Ser Ile Thr Pro Val Phe Ala Thr Thr
 145                 150                 155                 160
 Ile His Ser Val Pro Ser Ser Pro Tyr Ile Phe Ser Thr Glu Asn Val
                 165                 170                 175    
 Gly Ser Ala Ser Ile Thr Ala Phe Pro Ser Leu Ser Ser Ser Ser Thr
             180                 185                 190        
 Thr Ser Thr Ser Pro Thr Ser Ser Ser Leu Thr Thr Ala Leu Thr Glu
         195                 200                 205            
 Ile Thr Pro Phe Ser Tyr Ile Ser Leu Pro Ser Thr Thr Pro Cys Pro
     210                 215                 220                
 Gly Thr Ile Thr Ile Thr Ile Val Pro Ala Ser Pro Thr Asp Pro Cys
 225                 230                 235                 240
 Val Glu Met Asp Pro Ser Thr Glu Ala Thr Ser Pro Pro Thr Thr Pro
                 245                 250                 255    
 Leu Thr Val Phe Pro Phe Thr Thr Glu Met Val Thr Cys Pro Ser Ser
             260                 265                 270        
 Ile Ser Met Gln Thr Thr Leu Ala Thr His Met Asp Thr Ser Ser Met
         275                 280                 285            
 Thr Pro Glu Ser Glu Ser Ser Ile Ile Pro Asn Ala Ser Ser Ser Thr
     290                 295                 300                
 Gly Thr Gly Thr Val Pro Thr Asn Thr Val Phe Thr Ser Thr Arg Leu
 305                 310                 315                 320
 Pro Thr Ser Glu Thr Trp Leu Ser Asn Asn Ser Val Ile Pro Thr Pro
                 325                 330                 335    
 Leu Pro Gly Val Ser Thr Ile Pro Leu Thr Met Lys Pro Ser Ser Ser
             340                 345                 350        
 Leu Pro Thr Ile Leu Arg Thr Ser Ser Lys Ser Thr His Pro Ser Pro
         355                 360                 365            
 Pro Thr Ala Arg Thr Ser Glu Thr Ser Val Ala Thr Thr Gln Thr Pro
     370                 375                 380                
 Thr Thr Leu Thr Thr Arg Arg Thr Thr Pro Ile Thr Ser Trp Met Thr
 385                 390                 395                 400
 Thr Gln Ser Thr Leu Thr Thr Thr Ala Gly Thr Cys Asp Asn Gly Gly
                 405                 410                 415    
 Thr Trp Glu Gln Gly Gln Cys Ala Cys Leu Pro Gly Phe Ser Gly Asp
             420                 425                 430        
 Arg Cys Gln Leu Gln Thr Arg Cys Gln Asn Gly Gly Gln Trp Asp Gly
         435                 440                 445            
 Leu Lys Cys Gln Cys Pro Ser Thr Phe Tyr Gly Ser Ser Cys Glu Phe
     450                 455                 460                
 Ala Val Glu Gln Val Asp Leu Asp Val Val Glu Thr Glu Val Gly Met
 465                 470                 475                 480
 Glu Val Ser Val Asp Gln Gln Phe Ser Pro Asp Leu Asn Asp Asn Thr
                 485                 490                 495    
 Ser Gln Ala Tyr Arg Asp Phe Asn Lys Thr Phe Trp Asn Gln Met Gln
             500                 505                 510        
 Lys Ile Phe Ala Asp Met Gln Gly Phe Thr Phe Lys Gly Val Glu Ile
         515                 520                 525            
 Leu Ser Leu Arg Asn Gly Ser Ile Val Val Asp Tyr Leu Val Leu Leu
     530                 535                 540                
 Glu Met Pro Phe Ser Pro Gln Leu Glu Ser Glu Tyr Glu Gln Val Lys
 545                 550                 555                 560
 Thr Thr Leu Lys Glu Gly Leu Gln Asn Ala Ser Gln Asp Val Asn Ser
                 565                 570                 575    
 Cys Gln Asp Ser Gln Thr Leu Cys Phe Lys Pro Asp Ser Ile Lys Val
             580                 585                 590        
 Asn Asn Asn Ser Lys Thr Glu Leu Thr Pro Ala Ala Ile Cys Arg Arg
         595                 600                 605            
 Ala Ala Pro Thr Gly Tyr Glu Glu Phe Tyr Phe Pro Leu Val Glu Ala
     610                 615                 620                
 Thr Arg Leu Arg Cys Val Thr Lys Cys Thr Ser Gly Val Asp Asn Ala
 625                 630                 635                 640
 Ile Asp Cys His Gln Gly Gln Cys Val Leu Glu Thr Ser Gly Pro Thr
                 645                 650                 655    
 Cys Arg Cys Tyr Ser Thr Asp Thr His Trp Phe Ser Gly Pro Arg Cys
             660                 665                 670        
 Glu Val Ala Val His Trp Arg Ala Leu Val Gly Gly Leu Thr Ala Gly
         675                 680                 685            
 Ala Ala Leu Leu Val Leu Leu Leu Leu Ala Leu Gly Val Arg Ala Val
     690                 695                 700                
 Arg Ser Gly Trp Trp Gly Gly Gln Arg Arg Gly Arg Ser Trp Asp Gln
 705                 710                 715                 720
 Asp Arg Lys Trp Phe Glu Thr Trp Asp Glu Glu Val Val Gly Thr Phe
                 725                 730                 735    
 Ser Asn Trp Gly Phe Glu Asp Asp Gly Thr Asp Lys Asp Thr Asn Phe
             740                 745                 750        
 Tyr Val Ala Leu Glu Asn Val Asp Thr Thr Met Lys Val His Ile Lys
         755                 760                 765            
 Arg Pro Glu Met Thr Ser Ser Ser Val
     770                 775        



      <210> 543
      <211> 471
      <212> PRT
      <213> Homo sapiens


      <400> 543
 Met Glu Phe Val Thr Ala Leu Ala Asp Leu Arg Ala Glu Ala Ser Cys
   1               5                  10                  15    
 Pro Ile Cys Leu Asp Tyr Leu Lys Asp Pro Val Thr Ile Ser Cys Gly
              20                  25                  30        
 His Asn Phe Cys Leu Ser Cys Ile Ile Met Ser Trp Lys Asp Leu His
          35                  40                  45            
 Asp Ser Phe Pro Cys Pro Phe Cys His Phe Cys Cys Pro Glu Arg Lys
      50                  55                  60                
 Phe Ile Ser Asn Pro Gln Leu Gly Ser Leu Thr Glu Ile Ala Lys Gln
  65                  70                  75                  80
 Leu Gln Ile Arg Ser Lys Lys Arg Lys Arg Gln Glu Glu Lys His Val
                  85                  90                  95    
 Cys Lys Lys His Asn Gln Val Leu Thr Phe Phe Cys Gln Lys Asp Leu
             100                 105                 110        
 Glu Leu Leu Cys Pro Arg Cys Ser Leu Ser Thr Asp His Gln His His
         115                 120                 125            
 Cys Val Trp Pro Ile Lys Lys Ala Ala Ser Tyr His Arg Lys Lys Leu
     130                 135                 140                
 Glu Glu Tyr Asn Ala Pro Trp Lys Glu Arg Val Glu Leu Ile Glu Lys
 145                 150                 155                 160
 Val Ile Thr Met Gln Thr Arg Lys Ser Leu Glu Leu Lys Lys Lys Val
                 165                 170                 175    
 Lys His Arg Ala Glu Glu Val Lys Ser Glu Phe Glu Gln Leu Arg Leu
             180                 185                 190        
 Phe Leu Gln Asn Glu Gln Glu Thr Val Leu Arg Gln Leu Gln Asp Glu
         195                 200                 205            
 Glu Met Asp Ile Leu Ala Gln Leu Asn Glu Ser Leu Thr Lys Phe Ser
     210                 215                 220                
 Asp Tyr Thr Ser Ser Leu Lys Tyr Leu Leu Lys Glu Ile Glu Ser Ile
 225                 230                 235                 240
 Tyr Val Lys Ser Glu Leu Glu Leu Leu Ala Asn Val Lys Asp Ile Tyr
                 245                 250                 255    
 His Arg Tyr Lys Asn Leu Lys Phe Pro Glu Leu Phe Leu Phe Lys Leu
             260                 265                 270        
 Lys Lys Tyr Gly Tyr His Leu Pro Pro Gln Tyr Ser Gly Leu Asp Lys
         275                 280                 285            
 Ile Ile Lys Arg Phe Gln Val Asp Val Ile Leu Asp Pro Glu Thr Ala
     290                 295                 300                
 His Arg Lys Leu Ile Val Ser Glu Asp Arg Lys Thr Val Arg Tyr Gly
 305                 310                 315                 320
 Asn Thr Thr Gln Asn Val Pro His Asn Pro Arg Arg Phe Tyr Leu Leu
                 325                 330                 335    
 Pro Ala Val Leu Gly Ser Lys Gly Tyr Ser Cys Gly Arg Gln Tyr Trp
             340                 345                 350        
 Glu Val Glu Val Lys Asp Lys Pro Glu Trp Ile Leu Gly Val Cys Asn
         355                 360                 365            
 Asp Cys Leu Pro Arg Arg Arg Lys Ser Gln Pro Ile Leu Val Gln Asp
     370                 375                 380                
 Gly Leu Trp Gly Ile Trp Arg Ser Ser Gln Asn Asn Tyr Ile Val Leu
 385                 390                 395                 400
 Gly His Lys Glu Ile Ile Leu Leu Pro Gln Val Ile Pro Ser Lys Ile
                 405                 410                 415    
 Gly Ile Phe Leu Asp Tyr Glu Met Asn Glu Val Ser Phe Tyr Asn Leu
             420                 425                 430        
 Asn Asp Arg Ser Leu Leu Tyr Thr Phe Asn Asp Asn Phe Thr Gly Ala
         435                 440                 445            
 Leu Trp Pro Tyr Phe Tyr Thr Gly Thr Asp Ser Lys Pro Leu Lys Ile
     450                 455                 460                
 Ser Thr Val Thr Asp Ser Glu
 465                 470    



      <210> 544
      <211> 233
      <212> PRT
      <213> Homo sapiens


      <400> 544
 Met Ala Lys Lys Arg Asn Asn Asn Gly His Ala Lys Lys Gly His Ser
   1               5                  10                  15    
 His Val Gln Pro Ile Cys Tyr Met Asn Tyr Ala Leu Cys Leu Pro Lys
              20                  25                  30        
 Gly Lys Thr Ile Lys Lys Phe Ile Ile Gln Asn Val Val Glu Thr Ala
          35                  40                  45            
 Pro Val Arg Asp Ile Ser Glu Ala Ser Ile Phe Asp Ala Tyr Gly Leu
      50                  55                  60                
 Pro Lys Leu Phe Val Lys Phe Cys Tyr Ala Val Lys Ala Lys Asp Ala
  65                  70                  75                  80
 Lys Ser Leu Leu Pro Leu Met Ile Ile Met Val Ile Ile Phe Leu Val
                  85                  90                  95    
 Leu Leu Phe Trp Glu Asn Glu Val Asn Asp Glu Ala Val Met Ser Thr
             100                 105                 110        
 Leu Glu His Leu His Val Asp Tyr Pro Gln Asn Asp Val Pro Val Pro
         115                 120                 125            
 Ala Arg Tyr Cys Asn His Met Ile Ile Gln Arg Val Ile Arg Glu Pro
     130                 135                 140                
 Asp His Thr Cys Lys Lys Glu His Val Phe Ile His Glu Arg Pro Arg
 145                 150                 155                 160
 Lys Ile Asn Gly Ile Cys Ile Ser Pro Lys Lys Val Ala Cys Gln Asn
                 165                 170                 175    
 Leu Ser Ala Ile Phe Cys Phe Gln Ser Glu Thr Lys Phe Lys Met Thr
             180                 185                 190        
 Val Cys Gln Leu Ile Glu Gly Thr Arg Tyr Pro Ala Cys Arg Tyr His
         195                 200                 205            
 Tyr Ser Pro Thr Glu Gly Phe Val Leu Val Thr Cys Asp Asp Leu Arg
     210                 215                 220                
 Pro Asp Ser Phe Leu Gly Tyr Val Lys
 225                 230            



      <210> 545
      <211> 1137
      <212> PRT
      <213> Homo sapiens


      <400> 545
 Met Val Glu Pro Leu Glu Asp Arg Arg Gln Glu Asn Phe Phe Cys Gly
   1               5                  10                  15    
 Pro Pro Glu Lys Ser Tyr Ala Lys Leu Val Phe Met Ser Thr Ser Ser
              20                  25                  30        
 Gly Ser Leu Trp Asn Leu His Ala Ile His Ser Met Cys Arg Met Glu
          35                  40                  45            
 Gln Asp Gln Ile Arg Ser His Thr Ser Phe Gly Ala Leu Cys Gln Arg
      50                  55                  60                
 Thr Ala Ala Asn Gln Cys Cys Pro Ser Trp Ser Leu Gly Asn Tyr Leu
  65                  70                  75                  80
 Ala Val Leu Ser Asn Arg Ser Ser Cys Leu Asp Thr Thr Gln Ala Asp
                  85                  90                  95    
 Ala Ala Arg Thr Leu Ala Leu Leu Arg Thr Cys Ala Leu Tyr Tyr His
             100                 105                 110        
 Ser Gly Ala Leu Val Pro Ser Cys Leu Gly Pro Gly Gln Asn Lys Ser
         115                 120                 125            
 Pro Arg Cys Ala Gln Val Pro Thr Lys Cys Ser Gln Ser Ser Ala Ile
     130                 135                 140                
 Tyr Gln Leu Leu His Phe Leu Leu Asp Arg Asp Phe Leu Ser Pro Gln
 145                 150                 155                 160
 Thr Thr Asp Tyr Gln Val Pro Ser Leu Lys Tyr Ser Leu Leu Phe Leu
                 165                 170                 175    
 Pro Thr Pro Lys Gly Ala Ser Leu Met Asp Ile Tyr Leu Asp Arg Leu
             180                 185                 190        
 Ala Thr Pro Trp Gly Leu Ala Asp Asn Tyr Thr Ser Val Thr Gly Met
         195                 200                 205            
 Asp Leu Gly Leu Lys Gln Glu Leu Leu Arg His Phe Leu Val Gln Asp
     210                 215                 220                
 Thr Val Tyr Pro Leu Leu Ala Leu Val Ala Ile Phe Phe Gly Met Ala
 225                 230                 235                 240
 Leu Tyr Leu Arg Ser Leu Phe Leu Thr Leu Met Val Leu Leu Gly Val
                 245                 250                 255    
 Leu Gly Ser Leu Leu Val Ala Phe Phe Leu Tyr Gln Val Ala Phe Arg
             260                 265                 270        
 Met Ala Tyr Phe Pro Phe Val Asn Leu Ala Ala Leu Leu Leu Leu Ser
         275                 280                 285            
 Ser Val Cys Ala Asn His Thr Leu Ile Phe Phe Asp Leu Trp Arg Leu
     290                 295                 300                
 Ser Lys Ser Gln Leu Pro Ser Gly Gly Leu Ala Gln Arg Val Gly Arg
 305                 310                 315                 320
 Thr Met His His Phe Gly Tyr Leu Leu Leu Val Ser Gly Leu Thr Thr
                 325                 330                 335    
 Ser Ala Ala Phe Tyr Ala Ser Tyr Leu Ser Arg Leu Pro Ala Val Arg
             340                 345                 350        
 Cys Leu Ala Leu Phe Met Gly Thr Ala Val Leu Val His Leu Ala Leu
         355                 360                 365            
 Thr Leu Val Trp Leu Pro Ala Ser Ala Val Leu His Glu Arg Tyr Leu
     370                 375                 380                
 Ala Arg Gly Cys Ala Arg Arg Ala Arg Gly Arg Trp Glu Gly Ser Ala
 385                 390                 395                 400
 Pro Arg Arg Leu Leu Leu Ala Leu His Arg Arg Leu Arg Gly Leu Arg
                 405                 410                 415    
 Arg Ala Ala Ala Gly Thr Ser Arg Leu Leu Phe Gln Arg Leu Leu Pro
             420                 425                 430        
 Cys Gly Val Ile Lys Phe Arg Tyr Ile Trp Ile Cys Trp Phe Ala Ala
         435                 440                 445            
 Leu Ala Ala Gly Gly Ala Tyr Ile Ala Gly Val Ser Pro Arg Leu Arg
     450                 455                 460                
 Leu Pro Thr Leu Pro Pro Pro Gly Gly Gln Val Phe Arg Pro Ser His
 465                 470                 475                 480
 Pro Phe Glu Arg Phe Asp Ala Glu Tyr Arg Gln Leu Phe Leu Phe Glu
                 485                 490                 495    
 Gln Leu Pro Gln Gly Glu Gly Gly His Met Pro Val Val Leu Val Trp
             500                 505                 510        
 Gly Val Leu Pro Val Asp Thr Gly Asp Pro Leu Asp Pro Arg Ser Asn
         515                 520                 525            
 Ser Ser Leu Val Arg Asp Pro Ala Phe Ser Ala Ser Gly Pro Glu Ala
     530                 535                 540                
 Gln Arg Trp Leu Leu Ala Leu Cys His Arg Ala Arg Asn Gln Ser Phe
 545                 550                 555                 560
 Phe Asp Thr Leu Gln Glu Gly Trp Pro Thr Leu Cys Phe Val Glu Thr
                 565                 570                 575    
 Leu Gln Arg Trp Met Glu Ser Pro Ser Cys Ala Arg Leu Gly Pro Asp
             580                 585                 590        
 Leu Cys Cys Gly His Ser Asp Phe Pro Trp Ala Pro Gln Phe Phe Leu
         595                 600                 605            
 His Cys Leu Lys Met Met Ala Leu Glu Gln Gly Pro Asp Gly Thr Gln
     610                 615                 620                
 Asp Leu Gly Leu Arg Phe Asp Ala His Gly Ser Leu Ala Ala Leu Val
 625                 630                 635                 640
 Leu Gln Phe Gln Thr Asn Phe Arg Asn Ser Pro Asp Tyr Asn Gln Thr
                 645                 650                 655    
 Gln Leu Phe Tyr Asn Glu Val Ser His Trp Leu Ala Ala Glu Leu Gly
             660                 665                 670        
 Met Ala Pro Pro Gly Leu Arg Arg Gly Trp Phe Thr Ser Arg Leu Glu
         675                 680                 685            
 Leu Tyr Ser Leu Gln His Ser Leu Ser Thr Glu Pro Ala Val Val Leu
     690                 695                 700                
 Gly Leu Ala Leu Ala Leu Ala Phe Ala Thr Leu Leu Leu Gly Thr Trp
 705                 710                 715                 720
 Asn Val Pro Leu Ser Leu Phe Ser Val Ala Ala Val Ala Gly Thr Val
                 725                 730                 735    
 Leu Leu Thr Val Gly Leu Leu Val Leu Leu Glu Trp Gln Leu Asn Thr
             740                 745                 750        
 Ala Glu Ala Leu Phe Leu Ser Ala Ser Val Gly Leu Ser Val Asp Phe
         755                 760                 765            
 Thr Val Asn Tyr Cys Ile Ser Tyr His Leu Cys Pro His Pro Asp Arg
     770                 775                 780                
 Leu Ser Arg Val Ala Phe Ser Leu Arg Gln Thr Ser Cys Ala Thr Ala
 785                 790                 795                 800
 Val Gly Ala Ala Ala Leu Phe Ala Ala Gly Val Leu Met Leu Pro Ala
                 805                 810                 815    
 Thr Val Leu Leu Tyr Arg Lys Leu Gly Ile Ile Leu Met Met Val Lys
             820                 825                 830        
 Cys Val Ser Cys Gly Phe Ala Ser Phe Phe Phe Gln Ser Leu Cys Cys
         835                 840                 845            
 Phe Phe Gly Pro Glu Lys Asn Cys Gly Gln Ile Leu Trp Pro Cys Ala
     850                 855                 860                
 His Leu Pro Trp Asp Ala Gly Thr Gly Asp Pro Gly Gly Glu Lys Ala
 865                 870                 875                 880
 Gly Arg Pro Arg Pro Gly Ser Val Gly Gly Met Pro Gly Ser Cys Ser
                 885                 890                 895    
 Glu Gln Tyr Glu Leu Gln Pro Leu Ala Arg Arg Arg Ser Pro Ser Phe
             900                 905                 910        
 Asp Thr Ser Thr Ala Thr Ser Lys Leu Ser His Arg Pro Ser Val Leu
         915                 920                 925            
 Ser Glu Asp Leu Gln Leu His Asp Gly Pro Cys Cys Ser Arg Pro Pro
     930                 935                 940                
 Pro Ala Pro Ala Ser Pro Arg Glu Leu Leu Leu Asp His Gln Ala Val
 945                 950                 955                 960
 Phe Ser Gln Cys Pro Ala Leu Gln Thr Ser Ser Pro Tyr Lys Gln Ala
                 965                 970                 975    
 Gly Pro Ser Pro Lys Thr Arg Ala Arg Gln Asp Ser Gln Gly Glu Glu
             980                 985                 990        
 Ala Glu Pro Leu Pro Ala Ser Pro Glu Ala Pro Ala His Ser Pro Lys
         995                1000                1005            
 Ala Lys Ala Ala Asp Pro Pro Asp Gly Phe Cys Ser Ser Ala Ser Thr
    1010                1015                1020                
 Leu Glu Gly Leu Ser Val Ser Asp Glu Thr Cys Leu Ser Thr Ser Glu
1025                1030                1035                1040
 Pro Ser Ala Arg Val Pro Asp Ser Val Gly Val Ser Pro Asp Asp Leu
                1045                1050                1055    
 Asp Asp Thr Gly Gln Pro Val Leu Glu Arg Gly Gln Leu Asn Gly Lys
            1060                1065                1070        
 Arg Asp Thr Leu Trp Leu Ala Leu Arg Glu Thr Val Tyr Asp Pro Ser
        1075                1080                1085            
 Leu Pro Ala Ser His His Ser Ser Leu Ser Trp Lys Gly Arg Gly Gly
    1090                1095                1100                
 Pro Gly Asp Gly Ser Pro Val Val Leu Pro Asn Ser Gln Pro Asp Leu
1105                1110                1115                1120
 Pro Asp Val Trp Leu Arg Arg Pro Ser Thr His Thr Ser Gly Tyr Ser
                1125                1130                1135    
 Ser
    



      <210> 546
      <211> 255
      <212> PRT
      <213> Homo sapiens


      <400> 546
 Met Asn Pro Thr Ile Pro Ala Leu Asp Thr Glu Ile Ala Pro Ile Ser
   1               5                  10                  15    
 Asp Thr Glu Glu Thr His Pro His Arg Cys Gly Met Glu Val Leu Val
              20                  25                  30        
 Leu Ile Val Leu Ile Leu Ile Ile Asp Leu Val Gly Leu Ala Gly Asn
          35                  40                  45            
 Ala Val Met Leu Trp Leu Leu Gly Phe Cys Met His Ser Asn Thr Phe
      50                  55                  60                
 Ser Leu Tyr Ile Leu Asn Leu Ala Arg Ala Asp Phe Leu Cys Thr Cys
  65                  70                  75                  80
 Phe Gln Ile Ile Thr Phe Ile Asn Phe Phe Ser Asp Phe Val Ser Ser
                  85                  90                  95    
 Leu Ser Ile His Phe Ser Arg Phe Val Thr Thr Val Leu Phe Ser Ala
             100                 105                 110        
 Cys Ile Thr Gly Leu Ser Met Leu Ser Thr Ile Ser Thr Glu His Arg
         115                 120                 125            
 Leu Ser Val Leu Trp Pro Ile Trp Tyr Cys Cys His Cys Pro Thr His
     130                 135                 140                
 Leu Ser Ala Val Met Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Gln
 145                 150                 155                 160
 Ser Ile Leu Glu Trp Met Phe Cys Ser Phe Leu Phe Ser Asp Val Asp
                 165                 170                 175    
 Ser Asp Asn Trp Cys Gln Ile Leu Asp Phe Leu Thr Ala Val Trp Leu
             180                 185                 190        
 Ile Phe Leu Ile Cys Gly Ser Leu Trp Val His Pro Gly Pro Ala Cys
         195                 200                 205            
 Gln Asp His Met Trp Ile Pro Glu Asp Ala Ala Asp Gln Ala Val Cys
     210                 215                 220                
 Asp His Pro Ala His Arg Ala Gly Leu Pro Leu Leu Gln Pro Ala Pro
 225                 230                 235                 240
 Gln His Ser Val Ile Pro Ile Ile Leu Asp Arg Glu Gly Phe Gly
                 245                 250                 255



      <210> 547
      <211> 2113
      <212> PRT
      <213> Homo sapiens


      <400> 547
 Met Thr Gly Ala Gly Glu Pro Arg Arg Glu Glu Pro Pro Pro Gln Pro
   1               5                  10                  15    
 Ser Ala Gly Leu Arg Ser Arg Glu Ser Gly Ala Pro Ser Ala Gly Gly
              20                  25                  30        
 Trp Glu Arg Ala Glu Arg Gly Arg Gly Ala Ala Ala Arg Pro Ala Thr
          35                  40                  45            
 Gly Pro Pro Pro Arg Arg Ile Gly Pro Leu Tyr Gly Met Trp Leu Val
      50                  55                  60                
 Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys Ala Arg Pro Glu Asp
  65                  70                  75                  80
 Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser Leu Gln Gln Val Thr
                  85                  90                  95    
 Phe Ser Ser Ser Val Gly Val Val Val Pro Cys Pro Ala Ala Gly Ser
             100                 105                 110        
 Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr Gly Asp Asp Ile Tyr
         115                 120                 125            
 Asp Val Pro His Ile Arg His Val His Ala Asn Gly Thr Leu Gln Leu
     130                 135                 140                
 Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe Ile His Asp Asn Asp
 145                 150                 155                 160
 Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys Ile Arg Ser Pro Asn
                 165                 170                 175    
 Ile Arg Val Lys Ala Val Phe Arg Glu Pro Tyr Thr Val Arg Val Glu
             180                 185                 190        
 Asp Gln Arg Ser Met Arg Gly Asn Val Ala Val Phe Lys Cys Leu Ile
         195                 200                 205            
 Pro Ser Ser Val Gln Glu Tyr Val Ser Val Val Ser Trp Glu Lys Asp
     210                 215                 220                
 Thr Val Ser Ile Ile Pro Glu His Arg Phe Phe Ile Thr Tyr His Gly
 225                 230                 235                 240
 Gly Leu Tyr Ile Ser Asp Val Gln Lys Glu Asp Ala Leu Ser Thr Tyr
                 245                 250                 255    
 Arg Cys Ile Thr Lys His Lys Tyr Ser Gly Glu Thr Arg Gln Ser Asn
             260                 265                 270        
 Gly Ala Arg Leu Ser Val Thr Asp Pro Ala Glu Ser Ile Pro Thr Ile
         275                 280                 285            
 Leu Asp Gly Phe His Ser Gln Glu Val Trp Ala Gly His Thr Val Glu
     290                 295                 300                
 Leu Pro Cys Thr Ala Ser Gly Tyr Pro Ile Pro Ala Ile Arg Trp Leu
 305                 310                 315                 320
 Lys Asp Gly Arg Pro Leu Pro Ala Asp Ser Arg Trp Thr Lys Arg Ile
                 325                 330                 335    
 Thr Gly Leu Thr Ile Ser Asp Leu Arg Thr Glu Asp Ser Gly Thr Tyr
             340                 345                 350        
 Ile Cys Glu Val Thr Asn Thr Phe Gly Ser Ala Glu Ala Thr Gly Ile
         355                 360                 365            
 Leu Met Val Ile Asp Pro Leu His Val Thr Leu Thr Pro Lys Lys Leu
     370                 375                 380                
 Lys Thr Gly Ile Gly Ser Thr Val Ile Leu Ser Cys Ala Leu Thr Gly
 385                 390                 395                 400
 Ser Pro Glu Phe Thr Ile Arg Trp Tyr Arg Asn Thr Glu Leu Val Leu
                 405                 410                 415    
 Pro Asp Glu Ala Ile Ser Ile Arg Gly Leu Ser Asn Glu Thr Leu Leu
             420                 425                 430        
 Ile Thr Ser Ala Gln Lys Ser His Ser Gly Ala Tyr Gln Cys Phe Ala
         435                 440                 445            
 Thr Arg Lys Ala Gln Thr Ala Gln Asp Phe Ala Ile Ile Ala Leu Glu
     450                 455                 460                
 Asp Gly Thr Pro Arg Ile Val Ser Ser Phe Ser Glu Lys Val Val Asn
 465                 470                 475                 480
 Pro Gly Glu Gln Phe Ser Leu Met Cys Ala Ala Lys Gly Ala Pro Pro
                 485                 490                 495    
 Pro Thr Val Thr Trp Ala Leu Asp Asp Glu Pro Ile Val Arg Asp Gly
             500                 505                 510        
 Ser His Arg Thr Asn Gln Tyr Thr Met Ser Asp Gly Thr Thr Ile Ser
         515                 520                 525            
 His Met Asn Val Thr Gly Pro Gln Ile Arg Asp Gly Gly Val Tyr Arg
     530                 535                 540                
 Cys Thr Ala Arg Asn Leu Val Gly Ser Ala Glu Tyr Gln Ala Arg Ile
 545                 550                 555                 560
 Asn Val Arg Gly Pro Pro Ser Ile Arg Ala Met Arg Asn Ile Thr Ala
                 565                 570                 575    
 Val Ala Gly Arg Asp Thr Leu Ile Asn Cys Arg Val Ile Gly Tyr Pro
             580                 585                 590        
 Tyr Tyr Ser Ile Lys Trp Tyr Lys Asp Ala Leu Leu Leu Pro Asp Asn
         595                 600                 605            
 His Arg Gln Val Val Phe Glu Asn Gly Thr Leu Lys Leu Thr Asp Val
     610                 615                 620                
 Gln Lys Gly Met Asp Glu Gly Glu Tyr Leu Cys Ser Val Leu Ile Gln
 625                 630                 635                 640
 Pro Gln Leu Ser Ile Ser Gln Ser Val His Val Ala Val Lys Val Pro
                 645                 650                 655    
 Pro Leu Ile Gln Pro Phe Glu Phe Pro Pro Ala Ser Ile Gly Gln Leu
             660                 665                 670        
 Leu Tyr Ile Pro Cys Val Val Ser Ser Gly Asp Met Pro Ile Arg Ile
         675                 680                 685            
 Thr Trp Arg Lys Asp Gly Gln Val Ile Ile Ser Gly Ser Gly Val Thr
     690                 695                 700                
 Ile Glu Ser Lys Glu Phe Met Ser Ser Leu Gln Ile Ser Ser Val Ser
 705                 710                 715                 720
 Leu Lys His Asn Gly Asn Tyr Thr Cys Ile Ala Ser Asn Ala Ala Ala
                 725                 730                 735    
 Thr Val Ser Arg Glu Arg Gln Leu Ile Val Arg Val Pro Pro Arg Phe
             740                 745                 750        
 Val Val Gln Pro Asn Asn Gln Asp Gly Ile Tyr Gly Lys Ala Gly Val
         755                 760                 765            
 Leu Asn Cys Ser Val Asp Gly Tyr Pro Pro Pro Lys Val Met Trp Lys
     770                 775                 780                
 His Ala Lys Gly Ser Gly Asn Pro Gln Gln Tyr His Pro Val Pro Leu
 785                 790                 795                 800
 Thr Gly Arg Ile Gln Ile Leu Pro Asn Ser Ser Leu Leu Ile Arg His
                 805                 810                 815    
 Val Leu Glu Glu Asp Ile Gly Tyr Tyr Leu Cys Gln Ala Ser Asn Gly
             820                 825                 830        
 Val Gly Thr Asp Ile Ser Lys Ser Met Phe Leu Thr Val Lys Ile Pro
         835                 840                 845            
 Ala Met Ile Thr Ser His Pro Asn Thr Thr Ile Ala Ile Lys Gly His
     850                 855                 860                
 Ala Lys Glu Leu Asn Cys Thr Ala Arg Gly Glu Arg Pro Ile Ile Ile
 865                 870                 875                 880
 Arg Trp Glu Lys Gly Asp Thr Val Ile Asp Pro Asp Arg Val Met Arg
                 885                 890                 895    
 Tyr Ala Ile Ala Thr Lys Asp Asn Gly Asp Glu Val Val Ser Thr Leu
             900                 905                 910        
 Lys Leu Lys Pro Ala Asp Arg Gly Asp Ser Val Phe Phe Ser Cys His
         915                 920                 925            
 Ala Ile Asn Ser Tyr Gly Glu Asp Arg Gly Leu Ile Gln Leu Thr Val
     930                 935                 940                
 Gln Glu Pro Pro Asp Pro Pro Glu Leu Glu Ile Arg Glu Val Lys Ala
 945                 950                 955                 960
 Arg Ser Met Asn Leu Arg Trp Thr Gln Arg Phe Asp Gly Asn Ser Ile
                 965                 970                 975    
 Ile Thr Gly Phe Asp Ile Glu Tyr Lys Asn Lys Ser Asp Ser Trp Asp
             980                 985                 990        
 Phe Lys Gln Ser Thr Arg Asn Ile Ser Pro Thr Ile Asn Gln Ala Asn
         995                1000                1005            
 Ile Val Asp Leu His Pro Ala Ser Val Tyr Ser Ile Arg Met Tyr Ser
    1010                1015                1020                
 Phe Asn Lys Ile Gly Arg Ser Glu Pro Ser Lys Glu Leu Thr Ile Ser
1025                1030                1035                1040
 Thr Glu Glu Ala Ala Pro Asp Gly Pro Pro Met Asp Val Thr Leu Gln
                1045                1050                1055    
 Pro Val Thr Ser Gln Ser Ile Gln Val Thr Trp Lys Ala Pro Lys Lys
            1060                1065                1070        
 Glu Leu Gln Asn Gly Val Ile Arg Gly Tyr Gln Ile Gly Tyr Arg Glu
        1075                1080                1085            
 Asn Ser Pro Gly Ser Asn Gly Gln Tyr Ser Ile Val Glu Met Lys Ala
    1090                1095                1100                
 Thr Gly Asp Ser Glu Val Tyr Thr Leu Asp Asn Leu Lys Lys Phe Ala
1105                1110                1115                1120
 Gln Tyr Gly Val Val Val Gln Ala Phe Asn Arg Ala Gly Thr Gly Pro
                1125                1130                1135    
 Ser Ser Ser Glu Ile Asn Ala Thr Thr Leu Glu Asp Val Pro Ser Gln
            1140                1145                1150        
 Pro Pro Glu Asn Val Arg Ala Leu Ser Ile Thr Ser Asp Val Ala Val
        1155                1160                1165            
 Ile Ser Trp Ser Glu Pro Pro Arg Ser Thr Leu Asn Gly Val Leu Lys
    1170                1175                1180                
 Gly Tyr Arg Val Ile Phe Trp Ser Leu Tyr Val Asp Gly Glu Trp Gly
1185                1190                1195                1200
 Glu Met Gln Asn Ile Thr Thr Thr Arg Glu Arg Val Glu Leu Arg Gly
                1205                1210                1215    
 Met Glu Lys Phe Thr Asn Tyr Ser Val Gln Val Leu Ala Tyr Thr Gln
            1220                1225                1230        
 Ala Gly Asp Gly Val Arg Ser Ser Val Leu Tyr Ile Gln Thr Lys Glu
        1235                1240                1245            
 Asp Val Pro Gly Pro Pro Ala Gly Ile Lys Ala Val Pro Ser Ser Ala
    1250                1255                1260                
 Ser Ser Val Val Val Ser Trp Leu Pro Pro Thr Lys Pro Asn Gly Val
1265                1270                1275                1280
 Ile Arg Lys Tyr Thr Ile Phe Cys Ser Ser Pro Gly Ser Gly Gln Pro
                1285                1290                1295    
 Ala Pro Ser Glu Tyr Glu Thr Ser Pro Glu Gln Leu Phe Tyr Arg Ile
            1300                1305                1310        
 Ala His Leu Asn Arg Gly Gln Gln Tyr Leu Leu Trp Val Ala Ala Val
        1315                1320                1325            
 Thr Ser Ala Gly Arg Gly Asn Ser Ser Glu Lys Val Thr Ile Glu Pro
    1330                1335                1340                
 Ala Gly Lys Ala Pro Ala Lys Ile Ile Ser Phe Gly Gly Thr Val Thr
1345                1350                1355                1360
 Thr Pro Trp Met Lys Asp Val Arg Leu Pro Cys Asn Ser Val Gly Asp
                1365                1370                1375    
 Pro Ala Pro Ala Val Lys Trp Thr Lys Asp Ser Glu Asp Ser Ala Ile
            1380                1385                1390        
 Pro Val Ser Met Asp Gly His Arg Leu Ile His Thr Asn Gly Thr Leu
        1395                1400                1405            
 Leu Leu Arg Ala Val Lys Ala Glu Asp Ser Gly Tyr Tyr Thr Cys Thr
    1410                1415                1420                
 Ala Thr Asn Thr Gly Gly Phe Asp Thr Ile Ile Val Asn Leu Leu Val
1425                1430                1435                1440
 Gln Val Pro Pro Asp Gln Pro Arg Leu Thr Val Ser Lys Thr Ser Ala
                1445                1450                1455    
 Ser Ser Ile Thr Leu Thr Trp Ile Pro Gly Asp Asn Gly Gly Ser Ser
            1460                1465                1470        
 Ile Arg Gly Phe Val Leu Gln Tyr Ser Val Asp Asn Ser Glu Glu Trp
        1475                1480                1485            
 Lys Asp Val Phe Ile Ser Ser Ser Glu Arg Ser Phe Lys Leu Asp Ser
    1490                1495                1500                
 Leu Lys Cys Gly Thr Trp Tyr Lys Val Lys Leu Ala Ala Lys Asn Ser
1505                1510                1515                1520
 Val Gly Ser Gly Arg Ile Ser Glu Ile Ile Glu Ala Lys Thr His Gly
                1525                1530                1535    
 Arg Glu Pro Ser Phe Ser Lys Asp Gln His Leu Phe Thr His Ile Asn
            1540                1545                1550        
 Ser Thr His Ala Arg Leu Asn Leu Gln Gly Trp Asn Asn Gly Gly Cys
        1555                1560                1565            
 Pro Ile Thr Ala Ile Val Leu Glu Tyr Arg Pro Lys Gly Thr Trp Ala
    1570                1575                1580                
 Trp Gln Gly Leu Arg Ala Asn Ser Ser Gly Glu Val Phe Leu Thr Glu
1585                1590                1595                1600
 Leu Arg Glu Ala Thr Trp Tyr Glu Leu Arg Met Arg Ala Cys Asn Ser
                1605                1610                1615    
 Ala Gly Cys Gly Asn Glu Thr Ala Gln Phe Ala Thr Leu Asp Tyr Asp
            1620                1625                1630        
 Gly Ser Thr Ile Pro Pro Ile Lys Ser Ala Gln Gly Glu Gly Asp Asp
        1635                1640                1645            
 Val Lys Lys Leu Phe Thr Ile Gly Cys Pro Val Ile Leu Ala Thr Leu
    1650                1655                1660                
 Gly Val Ala Leu Leu Phe Ile Val Arg Lys Lys Arg Lys Glu Lys Arg
1665                1670                1675                1680
 Leu Lys Arg Leu Arg Asp Ala Lys Ser Leu Ala Glu Met Leu Ile Ser
                1685                1690                1695    
 Lys Asn Asn Arg Ser Phe Asp Thr Pro Val Lys Gly Pro Pro Gln Gly
            1700                1705                1710        
 Pro Arg Leu His Ile Asp Ile Pro Arg Val Gln Leu Leu Ile Glu Asp
        1715                1720                1725            
 Lys Glu Gly Ile Lys Gln Leu Gly Asp Asp Lys Ala Thr Ile Pro Val
    1730                1735                1740                
 Thr Asp Ala Glu Phe Ser Gln Ala Val Asn Pro Gln Ser Phe Cys Thr
1745                1750                1755                1760
 Gly Val Ser Leu His His Pro Thr Leu Ile Gln Ser Thr Gly Pro Leu
                1765                1770                1775    
 Ile Asp Met Ser Asp Ile Arg Pro Gly Thr Asn Pro Val Ser Arg Lys
            1780                1785                1790        
 Asn Val Lys Ser Ala His Ser Thr Arg Asn Arg Tyr Ser Ser Gln Trp
        1795                1800                1805            
 Thr Leu Thr Lys Cys Gln Ala Ser Thr Pro Ala Arg Thr Leu Thr Ser
    1810                1815                1820                
 Asp Trp Arg Thr Val Gly Ser Gln His Gly Val Thr Val Thr Glu Ser
1825                1830                1835                1840
 Asp Ser Tyr Ser Ala Ser Leu Ser Gln Asp Thr Asp Lys Gly Arg Asn
                1845                1850                1855    
 Ser Met Val Ser Thr Glu Ser Ala Ser Ser Thr Tyr Glu Glu Leu Ala
            1860                1865                1870        
 Arg Ala Tyr Glu His Ala Lys Leu Glu Glu Gln Leu Gln His Ala Lys
        1875                1880                1885            
 Phe Glu Ile Thr Glu Cys Phe Ile Ser Asp Ser Ser Ser Asp Gln Met
    1890                1895                1900                
 Thr Thr Gly Thr Asn Glu Asn Ala Asp Ser Met Thr Ser Met Ser Thr
1905                1910                1915                1920
 Pro Ser Glu Pro Gly Ile Cys Arg Phe Thr Ala Ser Pro Pro Lys Pro
                1925                1930                1935    
 Gln Asp Ala Asp Arg Gly Lys Asn Val Ala Val Pro Ile Pro His Arg
            1940                1945                1950        
 Ala Asn Lys Ser Asp Tyr Cys Asn Leu Pro Leu Tyr Ala Lys Ser Glu
        1955                1960                1965            
 Ala Phe Phe Arg Lys Ala Asp Gly Arg Glu Pro Cys Pro Val Val Pro
    1970                1975                1980                
 Pro Arg Glu Ala Ser Ile Arg Asn Leu Ala Arg Thr Tyr His Thr Gln
1985                1990                1995                2000
 Ala Arg His Leu Thr Leu Asp Pro Ala Ser Lys Ser Leu Gly Leu Pro
                2005                2010                2015    
 His Pro Gly Ala Pro Ala Ala Ala Ser Thr Ala Thr Leu Pro Gln Arg
            2020                2025                2030        
 Thr Leu Ala Met Pro Ala Pro Pro Ala Gly Thr Ala Pro Pro Ala Pro
        2035                2040                2045            
 Gly Pro Thr Pro Ala Glu Pro Pro Thr Ala Pro Ser Ala Ala Pro Pro
    2050                2055                2060                
 Ala Pro Ser Thr Glu Pro Pro Arg Ala Gly Gly Pro His Thr Lys Met
2065                2070                2075                2080
 Gly Gly Ser Arg Asp Ser Leu Leu Glu Met Ser Thr Ser Gly Val Gly
                2085                2090                2095    
 Arg Ser Gln Lys Gln Gly Ala Gly Ala Tyr Ser Lys Ser Tyr Thr Leu
            2100                2105                2110        
 Val
    



      <210> 548
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 548
 Met Ala Val Phe Leu Glu Ala Lys Asp Ala His Ser Val Leu Lys Arg
   1               5                  10                  15    
 Phe Pro Arg Ala Asn Glu Phe Leu Glu Glu Leu Arg Gln Gly Thr Ile
              20                  25                  30        
 Glu Arg Glu Cys Met Glu Glu Ile Cys Ser Tyr Glu Glu Val Lys Glu
          35                  40                  45            
 Val Phe Glu Asn Lys Glu Lys Thr Met Glu Phe Trp Lys Gly Tyr Pro
      50                  55                  60                
 Asn Ala Val Tyr Ser Val Arg Asp Pro Ser Gln Ser Ser Asp Ala Met
  65                  70                  75                  80
 Tyr Val Val Val Pro Leu Leu Gly Val Ala Leu Leu Ile Val Ile Ala
                  85                  90                  95    
 Leu Phe Ile Ile Trp Arg Cys Gln Leu Gln Lys Ala Thr Arg His His
             100                 105                 110        
 Pro Ser Tyr Ala Gln Asn Arg Tyr Leu Ala Ser Arg Ala Gly His Thr
         115                 120                 125            
 Leu Pro Arg Val Met Val Tyr Arg Gly Thr Val His Ser Gln Gly Glu
     130                 135                 140                
 Pro Ser Gly His Arg Glu Ala Ala Ser Ser Pro Gln Val Val Leu Gly
 145                 150                 155                 160
 Pro Ser Arg Gly Gly Arg Thr Thr Val Arg Leu Glu Ser Thr Leu Tyr
                 165                 170                 175    
 Leu Pro Glu Leu Ser Leu Ser Arg Leu Ser Ser Thr Thr Pro Pro Pro
             180                 185                 190        
 Ser Tyr Glu Glu Val Thr Ala Pro Gln Glu Ser Ser Ser Glu Glu Ala
         195                 200                 205            
 Ser Val Ser Tyr Ser Asp Pro Pro Pro Lys Tyr Glu Glu Ile Val Ala
     210                 215                 220                
 Ala Asn Pro Gly Ala Asp Lys
 225                 230    



      <210> 549
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 549
 Met Asp Ser Ser Thr Ala His Ser Pro Val Phe Leu Val Phe Pro Pro
   1               5                  10                  15    
 Glu Ile Thr Ala Ser Glu Tyr Glu Ser Thr Glu Leu Ser Ala Thr Thr
              20                  25                  30        
 Phe Ser Thr Gln Ser Pro Leu Gln Lys Leu Phe Ala Arg Lys Met Lys
          35                  40                  45            
 Ile Leu Gly Thr Ile Gln Ile Leu Phe Gly Ile Met Thr Phe Ser Phe
      50                  55                  60                
 Gly Val Ile Phe Leu Phe Thr Leu Leu Lys Pro Tyr Pro Arg Phe Pro
  65                  70                  75                  80
 Phe Ile Phe Leu Ser Gly Tyr Pro Phe Trp Gly Ser Val Leu Phe Ile
                  85                  90                  95    
 Asn Ser Gly Ala Phe Leu Ile Ala Val Lys Arg Lys Thr Thr Glu Thr
             100                 105                 110        
 Leu Gly Ile Leu Ile Thr Leu Met Thr Phe Ser Ile Ile Glu Leu Phe
         115                 120                 125            
 Ile Ser Leu Pro Phe Ser Ile Leu Gly Cys His Ser Glu Asp Cys Asp
     130                 135                 140                
 Cys Glu Gln Cys Cys
 145                



      <210> 550
      <211> 357
      <212> PRT
      <213> Homo sapiens


      <400> 550
 Met Asn Trp Val Asn Lys Ser Val Pro Gln Glu Phe Ile Leu Leu Val
   1               5                  10                  15    
 Phe Ser Asp Gln Pro Trp Leu Glu Ile Pro Pro Phe Val Met Phe Leu
              20                  25                  30        
 Phe Ser Tyr Ile Leu Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val
          35                  40                  45            
 Ser His Val Asp Phe Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser
      50                  55                  60                
 Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln
  65                  70                  75                  80
 Met Leu Val Asn Ile Cys Asn Thr Arg Lys Val Ile Ser Tyr Gly Gly
                  85                  90                  95    
 Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ser Thr Glu Cys
             100                 105                 110        
 Leu Leu Leu Ala Val Met Cys Phe Asp Arg Phe Val Ala Ile Cys Arg
         115                 120                 125            
 Pro Leu His Tyr Ser Ile Ile Met His Gln Arg Leu Cys Phe Gln Leu
     130                 135                 140                
 Ala Ala Ala Ser Trp Ile Ser Gly Phe Ser Asn Ser Val Leu Gln Ser
 145                 150                 155                 160
 Thr Trp Thr Leu Lys Met Pro Leu Cys Gly His Lys Glu Val Asp His
                 165                 170                 175    
 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val Asp Thr
             180                 185                 190        
 Thr Ala Asn Glu Ala Glu Leu Phe Phe Ile Ser Val Leu Phe Leu Leu
         195                 200                 205            
 Ile Pro Val Thr Leu Ile Leu Ile Ser Tyr Ala Phe Ile Val Gln Ala
     210                 215                 220                
 Val Leu Arg Ile Gln Ser Ala Glu Gly Gln Arg Lys Ala Phe Gly Thr
 225                 230                 235                 240
 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ile
                 245                 250                 255    
 Ser Met Tyr Leu Gln Pro Pro Ser Pro Ser Ser Lys Asp Arg Gly Lys
             260                 265                 270        
 Met Val Ser Leu Phe Cys Gly Ile Ile Ala Pro Met Leu Asn Pro Leu
         275                 280                 285            
 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Lys Arg Leu
     290                 295                 300                
 Val Ala Lys Ser Leu Leu Asn Gln Glu Ile Arg Asn Met Gln Met Ile
 305                 310                 315                 320
 Ser Phe Ala Lys Asp Thr Val Leu Thr Tyr Leu Thr Asn Phe Ser Ala
                 325                 330                 335    
 Ser Cys Pro Ile Phe Val Ile Thr Ile Glu Asn Tyr Cys Asn Leu Pro
             340                 345                 350        
 Gln Arg Lys Phe Pro
         355        



      <210> 551
      <211> 1088
      <212> PRT
      <213> Homo sapiens


      <400> 551
 Met Glu Ile Lys Asp Gln Gly Ala Gln Met Glu Pro Leu Leu Pro Thr
   1               5                  10                  15    
 Arg Asn Asp Glu Glu Ala Val Val Asp Arg Gly Gly Thr Arg Ser Ile
              20                  25                  30        
 Leu Lys Thr His Phe Glu Lys Glu Asp Leu Glu Gly His Arg Thr Leu
          35                  40                  45            
 Phe Ile Gly Val His Val Pro Leu Gly Gly Arg Lys Ser His Arg Arg
      50                  55                  60                
 His Arg His Arg Gly His Lys His Arg Lys Arg Asp Arg Glu Arg Asp
  65                  70                  75                  80
 Ser Gly Leu Glu Asp Gly Arg Glu Ser Pro Ser Phe Asp Thr Pro Ser
                  85                  90                  95    
 Gln Arg Val Gln Phe Ile Leu Gly Thr Glu Asp Asp Asp Glu Glu His
             100                 105                 110        
 Ile Pro His Asp Leu Phe Thr Glu Leu Asp Glu Ile Cys Trp Arg Glu
         115                 120                 125            
 Gly Glu Asp Ala Glu Trp Arg Glu Thr Ala Arg Trp Leu Lys Phe Glu
     130                 135                 140                
 Glu Asp Val Glu Asp Gly Gly Glu Arg Trp Ser Lys Pro Tyr Val Ala
 145                 150                 155                 160
 Thr Leu Ser Leu His Ser Leu Phe Glu Leu Arg Ser Cys Ile Leu Asn
                 165                 170                 175    
 Gly Thr Val Leu Leu Asp Met His Ala Asn Thr Leu Glu Glu Ile Ala
             180                 185                 190        
 Asp Met Val Leu Asp Gln Gln Val Ser Ser Gly Gln Leu Asn Glu Asp
         195                 200                 205            
 Val Arg His Arg Val His Glu Ala Leu Met Lys Gln His His His Gln
     210                 215                 220                
 Ser Gln Lys Lys Leu Thr Asn Arg Ile Pro Ile Val Arg Ser Phe Ala
 225                 230                 235                 240
 Asp Ile Gly Lys Lys Gln Ser Glu Pro Asn Ser Met Asp Lys Asn Ala
                 245                 250                 255    
 Gly Gln Val Val Ser Pro Gln Ser Ala Pro Ala Cys Val Glu Asn Lys
             260                 265                 270        
 Asn Asp Val Ser Arg Glu Asn Ser Thr Val Asp Phe Ser Lys Val Asp
         275                 280                 285            
 Leu His Phe Met Lys Lys Ile Pro Pro Gly Ala Glu Ala Ser Asn Ile
     290                 295                 300                
 Leu Val Gly Glu Leu Glu Phe Leu Asp Arg Thr Val Val Ala Phe Val
 305                 310                 315                 320
 Arg Leu Ser Pro Ala Val Leu Leu Gln Gly Leu Ala Glu Val Pro Ile
                 325                 330                 335    
 Pro Thr Arg Phe Leu Phe Ile Leu Leu Gly Pro Leu Gly Lys Gly Gln
             340                 345                 350        
 Gln Tyr His Glu Ile Gly Arg Ser Ile Ala Thr Leu Met Thr Asp Glu
         355                 360                 365            
 Val Phe His Asp Val Ala Tyr Lys Ala Lys Asp Arg Asn Asp Leu Val
     370                 375                 380                
 Ser Gly Ile Asp Glu Phe Leu Asp Gln Val Thr Val Leu Pro Pro Gly
 385                 390                 395                 400
 Glu Trp Asp Pro Ser Ile Arg Ile Glu Pro Pro Lys Asn Val Pro Ser
                 405                 410                 415    
 Gln Glu Lys Arg Lys Ile Pro Ala Val Pro Asn Gly Thr Ala Ala His
             420                 425                 430        
 Gly Glu Ala Glu Pro His Gly Gly His Ser Gly Pro Glu Leu Gln Arg
         435                 440                 445            
 Thr Gly Arg Ile Phe Gly Gly Leu Ile Leu Asp Ile Lys Arg Lys Ala
     450                 455                 460                
 Pro Tyr Phe Trp Ser Asp Phe Arg Asp Ala Phe Ser Leu Gln Cys Leu
 465                 470                 475                 480
 Ala Ser Phe Leu Phe Leu Tyr Cys Ala Cys Met Ser Pro Val Ile Thr
                 485                 490                 495    
 Phe Gly Gly Leu Leu Gly Glu Ala Thr Glu Gly Arg Ile Ser Ala Ile
             500                 505                 510        
 Glu Ser Leu Phe Gly Ala Ser Met Thr Gly Ile Ala Tyr Ser Leu Phe
         515                 520                 525            
 Gly Gly Gln Pro Leu Thr Ile Leu Gly Ser Thr Gly Pro Val Leu Val
     530                 535                 540                
 Phe Glu Lys Ile Leu Phe Lys Phe Cys Lys Glu Tyr Gly Leu Ser Tyr
 545                 550                 555                 560
 Leu Ser Leu Arg Ala Ser Ile Gly Leu Trp Thr Ala Thr Leu Cys Ile
                 565                 570                 575    
 Ile Leu Val Ala Thr Asp Ala Ser Ser Leu Val Cys Tyr Ile Thr Arg
             580                 585                 590        
 Phe Thr Glu Glu Ala Phe Ala Ser Leu Ile Cys Ile Ile Phe Ile Tyr
         595                 600                 605            
 Glu Ala Leu Glu Lys Leu Phe Glu Leu Ser Glu Ala Tyr Pro Ile Asn
     610                 615                 620                
 Met His Asn Asp Leu Glu Leu Leu Thr Gln Tyr Ser Cys Asn Cys Val
 625                 630                 635                 640
 Glu Pro His Asn Pro Ser Asn Gly Thr Leu Lys Glu Trp Arg Glu Ser
                 645                 650                 655    
 Asn Ile Ser Ala Ser Asp Ile Ile Trp Glu Asn Leu Thr Val Ser Glu
             660                 665                 670        
 Cys Lys Ser Leu His Gly Glu Tyr Val Gly Arg Ala Cys Gly His Asp
         675                 680                 685            
 His Pro Tyr Val Pro Asp Val Leu Phe Trp Ser Val Ile Leu Phe Phe
     690                 695                 700                
 Ser Thr Val Thr Leu Ser Ala Thr Leu Lys Gln Phe Lys Thr Ser Arg
 705                 710                 715                 720
 Tyr Phe Pro Thr Lys Val Arg Ser Ile Val Ser Asp Phe Ala Val Phe
                 725                 730                 735    
 Leu Thr Ile Leu Cys Met Val Leu Ile Asp Tyr Ala Ile Gly Ile Pro
             740                 745                 750        
 Ser Pro Lys Leu Gln Val Pro Ser Val Phe Lys Pro Thr Arg Asp Asp
         755                 760                 765            
 Arg Gly Trp Phe Val Thr Pro Leu Gly Pro Asn Pro Trp Trp Thr Val
     770                 775                 780                
 Ile Ala Ala Ile Ile Pro Ala Leu Leu Cys Thr Ile Leu Ile Phe Met
 785                 790                 795                 800
 Asp Gln Gln Ile Thr Ala Val Ile Ile Asn Arg Lys Glu His Lys Leu
                 805                 810                 815    
 Lys Lys Gly Cys Gly Tyr His Leu Asp Leu Leu Met Val Ala Val Met
             820                 825                 830        
 Leu Gly Val Cys Ser Ile Met Gly Leu Pro Trp Phe Val Ala Ala Thr
         835                 840                 845            
 Val Leu Ser Ile Thr His Val Asn Ser Leu Lys Leu Glu Ser Glu Cys
     850                 855                 860                
 Ser Ala Pro Gly Glu Gln Pro Lys Phe Leu Gly Ile Arg Glu Gln Arg
 865                 870                 875                 880
 Val Thr Gly Leu Met Ile Phe Ile Leu Met Gly Ser Ser Val Phe Met
                 885                 890                 895    
 Thr Ser Ile Leu Lys Phe Ile Pro Met Pro Val Leu Tyr Gly Val Phe
             900                 905                 910        
 Leu Tyr Met Gly Ala Ser Ser Leu Lys Gly Ile Gln Phe Phe Asp Arg
         915                 920                 925            
 Ile Lys Leu Phe Trp Met Pro Ala Lys His Gln Pro Asp Phe Ile Tyr
     930                 935                 940                
 Leu Arg His Val Pro Leu Arg Lys Val His Leu Phe Thr Ile Ile Gln
 945                 950                 955                 960
 Met Ser Cys Leu Gly Leu Leu Trp Ile Ile Lys Val Ser Arg Ala Ala
                 965                 970                 975    
 Ile Val Phe Pro Met Met Val Leu Ala Leu Val Phe Val Arg Lys Leu
             980                 985                 990        
 Met Asp Leu Leu Phe Thr Lys Arg Glu Leu Ser Trp Leu Asp Asp Leu
         995                1000                1005            
 Met Pro Glu Ser Lys Lys Lys Lys Leu Glu Tyr Ala Glu Lys Glu Glu
    1010                1015                1020                
 Glu Gln Cys Val Leu Pro Met Glu Asp Glu Gly Thr Val Gln Leu Pro
1025                1030                1035                1040
 Leu Glu Gly His Tyr Arg Asp Asp Pro Ser Val Ile Asn Ile Ser Asp
                1045                1050                1055    
 Glu Met Ser Lys Thr Ala Leu Trp Arg Asn Leu Leu Ile Thr Ala Asp
            1060                1065                1070        
 Asn Ser Lys Asp Lys Glu Ser Ser Phe Pro Ser Lys Ser Ser Pro Ser
        1075                1080                1085            





      <210> 552
      <211> 404
      <212> PRT
      <213> Homo sapiens


      <400> 552
 Met Glu Leu Arg Val Ser Asn Thr Ser Cys Glu Asn Gly Ser Leu Leu
   1               5                  10                  15    
 His Leu Tyr Cys Ser Ser Gln Glu Val Leu Cys Gln Ile Val Asn Asp
              20                  25                  30        
 Leu Ser Pro Glu Val Pro Ser Asn Ala Thr Phe His Ser Trp Gln Glu
          35                  40                  45            
 Arg Ile Arg Gln Asn Tyr Gly Phe Tyr Ile Gly Leu Gly Leu Ala Phe
      50                  55                  60                
 Leu Ser Ser Phe Leu Ile Gly Ser Ser Val Ile Leu Lys Lys Lys Gly
  65                  70                  75                  80
 Leu Leu Arg Leu Val Ala Thr Gly Ala Thr Arg Ala Val Asp Gly Gly
                  85                  90                  95    
 Phe Gly Tyr Leu Lys Asp Ala Met Trp Trp Ala Gly Phe Leu Thr Met
             100                 105                 110        
 Ala Ala Gly Glu Val Ala Asn Phe Gly Ala Tyr Ala Phe Ala Pro Ala
         115                 120                 125            
 Thr Val Val Thr Pro Leu Gly Ala Leu Ser Val Leu Ile Ser Ala Ile
     130                 135                 140                
 Leu Ser Ser Tyr Phe Leu Arg Glu Ser Leu Asn Leu Leu Gly Lys Leu
 145                 150                 155                 160
 Gly Cys Val Ile Cys Val Ala Gly Ser Thr Val Met Val Ile His Ala
                 165                 170                 175    
 Pro Glu Glu Glu Lys Val Thr Thr Ile Met Glu Met Ala Ser Lys Val
             180                 185                 190        
 Lys Asp Thr Gly Phe Ile Val Phe Ala Val Leu Leu Leu Val Ser Cys
         195                 200                 205            
 Leu Ile Leu Ile Phe Val Ile Ala Pro Cys Tyr Gly Gln Arg Asn Ile
     210                 215                 220                
 Leu Ile Tyr Ile Ile Ile Cys Ser Val Ile Gly Ala Phe Ser Val Ala
 225                 230                 235                 240
 Ala Val Lys Gly Leu Gly Ile Thr Ile Lys Asn Phe Phe Gln Gly Leu
                 245                 250                 255    
 Pro Val Val Arg His Pro Leu Pro Tyr Ile Leu Ser Leu Ile Leu Ala
             260                 265                 270        
 Leu Thr Leu Ser Thr Gln Val Asn Phe Leu Asn Arg Ala Pro Asp Ile
         275                 280                 285            
 Phe Asn Thr Ser Leu Val Phe Pro Ile Tyr Tyr Val Phe Phe Thr Thr
     290                 295                 300                
 Val Val Val Thr Ser Ser Ile Ile Leu Phe Lys Glu Trp Tyr Ser Met
 305                 310                 315                 320
 Ser Ala Val Asp Ile Ala Gly Thr Leu Ser Gly Phe Val Thr Ile Ile
                 325                 330                 335    
 Leu Gly Val Phe Met Leu His Ala Phe Lys Asp Leu Asp Ile Ser Cys
             340                 345                 350        
 Ala Ser Leu Pro His Met His Lys Asn Pro Pro Pro Ser Pro Ala Pro
         355                 360                 365            
 Glu Pro Thr Val Ile Arg Leu Glu Asp Lys Asn Val Leu Val Asp Asn
     370                 375                 380                
 Ile Glu Leu Ala Ser Thr Ser Ser Pro Glu Glu Lys Pro Lys Val Phe
 385                 390                 395                 400
 Ile Ile His Ser
                



      <210> 553
      <211> 3111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3111)
      <223> n = a,t,c or g


      <400> 553
 tcaacaagat ggtgaattga ctagtgggta gatccacagg acgggtgtgg tcgccatgat     60
 cgcgtagtcg atagtggctc caagtagcga agcgagcagg actgggcggc ggccaaagcg    120
 gtcggacagt gctccgagaa cgggtgcgca tagaaattgc atcaacgcat atagcgctag    180
 cagcacgcca tagtgactgg cgatgctgtc ggaatggacg atatcccgca agaggcccgg    240
 cagtaccggc ataaccaagc ctatgcctac agcatccagg gtgacggtgc cgaggatgac    300
 gatgagcgca ttgttagatt tcatacacgg tgcctgacag tcaaagagcc gaacgctgtg    360
 cactgggtcc aggatgactt gcacaccctg ttcactgcgc agtttccgac caccatggac    420
 aggggaatct tggaacacca gtctcactcg atgatgccgc atgtccgtgc tcacattgat    480
 agtaaacaga gtaaatatca ttcccatgac aatcggaata aagatgaaat tgagggtggt    540
 gacctgcagt aggcagcagt cctggtctgg attggtatga acatcttcgt actgaacggg    600
 aggctgcaat cctcctgtac acttgctctt taacctaggg gactgttttt tgaacttgaa    660
 gttgaattcc cacattggtt cctgtctgtt cccaacaatc tttctgcacc agaaaagtaa    720
 gcatttggaa ttctttaatg tgctgggggt gctttctgga atggctggat tcttggagat    780
 tcgagcagca aatggctcat acatatggta cagagatcgg atcacacaag cccggagaca    840
 gtgcagcttc tccattgact ctggtcgcag acgcaaaggc agggaagcat ccagcgtgta    900
 gtgccttcgg tacaacctgg tccaaaaggc agcagtgcaa gtgacagtcc aggcattctt    960
 acaaatcagg gaaaaattca caatgtcctc aggacggata taggaggcca gcaatagcca   1020
 aatatccatg ggatactctt ctcctccagc cccgtccagt tcttctttgt gtctcttgct   1080
 tttctttttt ctggagacag ttctctcatg gatgttttcc tcctgggcat ccatctcatc   1140
 actgctgtcg atgatgtcat agggctcacc agccccagaa agagcttcct ctgcaggaac   1200
 atgagaggct tccaagccac aaagagattt tacttcctgc cgaacagcgt tgagctgatg   1260
 cttttgcctc acaactctta agattctttc ctttgtcttg actttaagta acctgatgat   1320
 tatgtgccta gagggtgttc tttttgtgat gaatttccca ggtgttcttt gagcttcttg   1380
 gatttggatg tctagatctc taacaaagcc aaggaaattt tcatcgatta ttagcgcaaa   1440
 tatgttttcc agacttttag atttctcttc ttcctttttt tctgtggaac ttttctgcca   1500
 cctccggggg cagatcgctt tccagataaa cttgagtttc acatactcct cttcttcatc   1560
 ttctgactct gcatcttcct ccacagctac taagtgctgt ccactaatat gcactggctc   1620
 tgaagcacac ttcaaccgta agatcaccag tggtgttatt tcaaggcccc cagaaaccat   1680
 tggctgtaca gacattttca aagttgccag tgttacttta atcggactgc cttcataatt   1740
 cattgcctct gtttcaacaa tatgcaattt atcctttgct ccagtccctg aaatcaccgt   1800
 tcttaaagat aactggtgct cattttcatc attattcacc ttaaagtgat aatctttgtc   1860
 ggccttttgt tgacaactga aaagatagtt ctggggcctc agagggctca tgtccatgtc   1920
 catcaaatct tccatggggt ggtgacacgc atcacctcta ccagctctgc cgacagccac   1980
 attgtatgtt ggctccccac cttgactctt tgtccggatg tccattgtgc agtcaccatc   2040
 gacgtataga ctatctctga tcactgagca tttcttcgcg ccaagagtca aaccgttggt   2100
 aaagaaacct tcccggtctt ttcctacaat catatctatt tctattggcg taatgctctg   2160
 aaagacgccc ccggccgtgg ctgcccagac gtatttggcg tcgcagtagc cgacaatggc   2220
 ggcctcctgg cagcagccat cgcacatcag gttatccacg tagctctgcc aaccggccat   2280
 cttcgagccc ttcgcattgn ccacgacatc atgttcatta atttcatttt ctgcatcact   2340
 actgtcagta tcttcattgt cgtcttcctc atagtctgaa gattctgtca tgttctgatg   2400
 tgagcgggat tccgataaag ccccaaatga ctgggcactg acagaagcta aaggtctcag   2460
 taaaggggta tgttctgtca cttcattttc ttcttgacta ctgtctgtgt cagagtctga   2520
 atcgccttga gaaggaacaa ctttttgctt gcacactgga caggtttttt tggttttagt   2580
 tagccaaggg tctacacact tgcagtgata agcatgggaa cagggaagga ttctgagttt   2640
 gtctccatct tcatactcat ccaaacaaat ggcacataca tcatactcat ctcctttggt   2700
 ctttgatgat ggtgacgtac agatggggtt ttggtgtaga tgtcctttct gtttgttagt   2760
 tttccttcta acagtcagga ccctcagctg caggtctgtt ggagtttgct ggaggtccac   2820
 tccagaccct gtttgcctgg gtatcagcag cagaggtcgg gaagtgcaag gggtcaggga   2880
 gttccctttc ctagccaaag aaaggggtga tggacggaac ctggaaaatc gggtcactcc   2940
 cacccgaata ctgcgctttc ccgacgggct agaaaaacgg tgcaccacga gattatatcc   3000
 cacacctggc tcggagggtc ctacgcccac ggagtctccc tgattgctag cacagcagtc   3060
 ggagatcaaa ctgcaaggca gcagcgtggc tgggggaggg gcgcccgcca t            3111



      <210> 554
      <211> 3111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3111)
      <223> n = a,t,c or g


      <400> 554
 tcaacaagat ggtgaattga ctagtgggta gatccacagg acgggtgtgg tcgccatgat     60
 cgcgtagtcg atagtggctc caagtagcga agcgagcagg actgggcggc ggccaaagcg    120
 gtcggacagt gctccgagaa cgggtgcgca tagaaattgc atcaacgcat atagcgctag    180
 cagcacgcca tagtgactgg cgatgctgtc ggaatggacg atatcccgca agaggcccgg    240
 cagtaccggc ataaccaagc ctatgcctac agcatccagg gtgacggtgc cgaggatgac    300
 gatgagcgca ttgttagatt tcatacacgg tgcctgacag tcaaagagcc gaacgctgtg    360
 cactgggtcc aggatgactt gcacaccctg ttcactgcgc agtttccgac caccatggac    420
 aggggaatct tggaacacca gtctcactcg atgatgccgc atgtccgtgc tcacattgat    480
 agtaaacaga gtaaatatca ttcccatgac aatcggaata aagatgaaat tgagggtggt    540
 gacctgcagt aggcagcagt cctggtctgg attggtatga acatcttcgt actgaacggg    600
 aggctgcaat cctcctgtac acttgctctt taacctaggg gactgttttt tgaacttgaa    660
 gttgaattcc cacattggtt cctgtctgtt cccaacaatc tttctgcacc agaaaagtaa    720
 gcatttggaa ttctttaatg tgctgggggt gctttctgga atggctggat tcttggagat    780
 tcgagcagca aatggctcat acatatggta cagagatcgg atcacacaag cccggagaca    840
 gtgcagcttc tccattgact ctggtcgcag acgcaaaggc agggaagcat ccagcgtgta    900
 gtgccttcgg tacaacctgg tccaaaaggc agcagtgcaa gtgacagtcc aggcattctt    960
 acaaatcagg gaaaaattca caatgtcctc aggacggata taggaggcca gcaatagcca   1020
 aatatccatg ggatactctt ctcctccagc cccgtccagt tcttctttgt gtctcttgct   1080
 tttctttttt ctggagacag ttctctcatg gatgttttcc tcctgggcat ccatctcatc   1140
 actgctgtcg atgatgtcat agggctcacc agccccagaa agagcttcct ctgcaggaac   1200
 atgagaggct tccaagccac aaagagattt tacttcctgc cgaacagcgt tgagctgatg   1260
 cttttgcctc acaactctta agattctttc ctttgtcttg actttaagta acctgatgat   1320
 tatgtgccta gagggtgttc tttttgtgat gaatttccca ggtgttcttt gagcttcttg   1380
 gatttggatg tctagatctc taacaaagcc aaggaaattt tcatcgatta ttagcgcaaa   1440
 tatgttttcc agacttttag atttctcttc ttcctttttt tctgtggaac ttttctgcca   1500
 cctccggggg cagatcgctt tccagataaa cttgagtttc acatactcct cttcttcatc   1560
 ttctgactct gcatcttcct ccacagctac taagtgctgt ccactaatat gcactggctc   1620
 tgaagcacac ttcaaccgta agatcaccag tggtgttatt tcaaggcccc cagaaaccat   1680
 tggctgtaca gacattttca aagttgccag tgttacttta atcggactgc cttcataatt   1740
 cattgcctct gtttcaacaa tatgcaattt atcctttgct ccagtccctg aaatcaccgt   1800
 tcttaaagat aactggtgct cattttcatc attattcacc ttaaagtgat aatctttgtc   1860
 ggccttttgt tgacaactga aaagatagtt ctggggcctc agagggctca tgtccatgtc   1920
 catcaaatct tccatggggt ggtgacacgc atcacctcta ccagctctgc cgacagccac   1980
 attgtatgtt ggctccccac cttgactctt tgtccggatg tccattgtgc agtcaccatc   2040
 gacgtataga ctatctctga tcactgagca tttcttcgcg ccaagagtca aaccgttggt   2100
 aaagaaacct tcccggtctt ttcctacaat catatctatt tctattggcg taatgctctg   2160
 aaagacgccc ccggccgtgg ctgcccagac gtatttggcg tcgcagtagc cgacaatggc   2220
 ggcctcctgg cagcagccat cgcacatcag gttatccacg tagctctgcc aaccggccat   2280
 cttcgagccc ttcgcattgn ccacgacatc atgttcatta atttcatttt ctgcatcact   2340
 actgtcagta tcttcattgt cgtcttcctc atagtctgaa gattctgtca tgttctgatg   2400
 tgagcgggat tccgataaag ccccaaatga ctgggcactg acagaagcta aaggtctcag   2460
 taaaggggta tgttctgtca cttcattttc ttcttgacta ctgtctgtgt cagagtctga   2520
 atcgccttga gaaggaacaa ctttttgctt gcacactgga caggtttttt tggttttagt   2580
 tagccaaggg tctacacact tgcagtgata agcatgggaa cagggaagga ttctgagttt   2640
 gtctccatct tcatactcat ccaaacaaat ggcacataca tcatactcat ctcctttggt   2700
 ctttgatgat ggtgacgtac agatggggtt ttggtgtaga tgtcctttct gtttgttagt   2760
 tttccttcta acagtcagga ccctcagctg caggtctgtt ggagtttgct ggaggtccac   2820
 tccagaccct gtttgcctgg gtatcagcag cagaggtcgg gaagtgcaag gggtcaggga   2880
 gttccctttc ctagccaaag aaaggggtga tggacggaac ctggaaaatc gggtcactcc   2940
 cacccgaata ctgcgctttc ccgacgggct agaaaaacgg tgcaccacga gattatatcc   3000
 cacacctggc tcggagggtc ctacgcccac ggagtctccc tgattgctag cacagcagtc   3060
 ggagatcaaa ctgcaaggca gcagcgtggc tgggggaggg gcgcccgcca t            3111



      <210> 555
      <211> 3111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(3111)
      <223> n = a,t,c or g


      <400> 555
 tcaacaagat ggtgaattga ctagtgggta gatccacagg acgggtgtgg tcgccatgat     60
 cgcgtagtcg atagtggctc caagtagcga agcgagcagg actgggcggc ggccaaagcg    120
 gtcggacagt gctccgagaa cgggtgcgca tagaaattgc atcaacgcat atagcgctag    180
 cagcacgcca tagtgactgg cgatgctgtc ggaatggacg atatcccgca agaggcccgg    240
 cagtaccggc ataaccaagc ctatgcctac agcatccagg gtgacggtgc cgaggatgac    300
 gatgagcgca ttgttagatt tcatacacgg tgcctgacag tcaaagagcc gaacgctgtg    360
 cactgggtcc aggatgactt gcacaccctg ttcactgcgc agtttccgac caccatggac    420
 aggggaatct tggaacacca gtctcactcg atgatgccgc atgtccgtgc tcacattgat    480
 agtaaacaga gtaaatatca ttcccatgac aatcggaata aagatgaaat tgagggtggt    540
 gacctgcagt aggcagcagt cctggtctgg attggtatga acatcttcgt actgaacggg    600
 aggctgcaat cctcctgtac acttgctctt taacctaggg gactgttttt tgaacttgaa    660
 gttgaattcc cacattggtt cctgtctgtt cccaacaatc tttctgcacc agaaaagtaa    720
 gcatttggaa ttctttaatg tgctgggggt gctttctgga atggctggat tcttggagat    780
 tcgagcagca aatggctcat acatatggta cagagatcgg atcacacaag cccggagaca    840
 gtgcagcttc tccattgact ctggtcgcag acgcaaaggc agggaagcat ccagcgtgta    900
 gtgccttcgg tacaacctgg tccaaaaggc agcagtgcaa gtgacagtcc aggcattctt    960
 acaaatcagg gaaaaattca caatgtcctc aggacggata taggaggcca gcaatagcca   1020
 aatatccatg ggatactctt ctcctccagc cccgtccagt tcttctttgt gtctcttgct   1080
 tttctttttt ctggagacag ttctctcatg gatgttttcc tcctgggcat ccatctcatc   1140
 actgctgtcg atgatgtcat agggctcacc agccccagaa agagcttcct ctgcaggaac   1200
 atgagaggct tccaagccac aaagagattt tacttcctgc cgaacagcgt tgagctgatg   1260
 cttttgcctc acaactctta agattctttc ctttgtcttg actttaagta acctgatgat   1320
 tatgtgccta gagggtgttc tttttgtgat gaatttccca ggtgttcttt gagcttcttg   1380
 gatttggatg tctagatctc taacaaagcc aaggaaattt tcatcgatta ttagcgcaaa   1440
 tatgttttcc agacttttag atttctcttc ttcctttttt tctgtggaac ttttctgcca   1500
 cctccggggg cagatcgctt tccagataaa cttgagtttc acatactcct cttcttcatc   1560
 ttctgactct gcatcttcct ccacagctac taagtgctgt ccactaatat gcactggctc   1620
 tgaagcacac ttcaaccgta agatcaccag tggtgttatt tcaaggcccc cagaaaccat   1680
 tggctgtaca gacattttca aagttgccag tgttacttta atcggactgc cttcataatt   1740
 cattgcctct gtttcaacaa tatgcaattt atcctttgct ccagtccctg aaatcaccgt   1800
 tcttaaagat aactggtgct cattttcatc attattcacc ttaaagtgat aatctttgtc   1860
 ggccttttgt tgacaactga aaagatagtt ctggggcctc agagggctca tgtccatgtc   1920
 catcaaatct tccatggggt ggtgacacgc atcacctcta ccagctctgc cgacagccac   1980
 attgtatgtt ggctccccac cttgactctt tgtccggatg tccattgtgc agtcaccatc   2040
 gacgtataga ctatctctga tcactgagca tttcttcgcg ccaagagtca aaccgttggt   2100
 aaagaaacct tcccggtctt ttcctacaat catatctatt tctattggcg taatgctctg   2160
 aaagacgccc ccggccgtgg ctgcccagac gtatttggcg tcgcagtagc cgacaatggc   2220
 ggcctcctgg cagcagccat cgcacatcag gttatccacg tagctctgcc aaccggccat   2280
 cttcgagccc ttcgcattgn ccacgacatc atgttcatta atttcatttt ctgcatcact   2340
 actgtcagta tcttcattgt cgtcttcctc atagtctgaa gattctgtca tgttctgatg   2400
 tgagcgggat tccgataaag ccccaaatga ctgggcactg acagaagcta aaggtctcag   2460
 taaaggggta tgttctgtca cttcattttc ttcttgacta ctgtctgtgt cagagtctga   2520
 atcgccttga gaaggaacaa ctttttgctt gcacactgga caggtttttt tggttttagt   2580
 tagccaaggg tctacacact tgcagtgata agcatgggaa cagggaagga ttctgagttt   2640
 gtctccatct tcatactcat ccaaacaaat ggcacataca tcatactcat ctcctttggt   2700
 ctttgatgat ggtgacgtac agatggggtt ttggtgtaga tgtcctttct gtttgttagt   2760
 tttccttcta acagtcagga ccctcagctg caggtctgtt ggagtttgct ggaggtccac   2820
 tccagaccct gtttgcctgg gtatcagcag cagaggtcgg gaagtgcaag gggtcaggga   2880
 gttccctttc ctagccaaag aaaggggtga tggacggaac ctggaaaatc gggtcactcc   2940
 cacccgaata ctgcgctttc ccgacgggct agaaaaacgg tgcaccacga gattatatcc   3000
 cacacctggc tcggagggtc ctacgcccac ggagtctccc tgattgctag cacagcagtc   3060
 ggagatcaaa ctgcaaggca gcagcgtggc tgggggaggg gcgcccgcca t            3111



      <210> 556
      <211> 2362
      <212> DNA
      <213> Homo sapiens


      <400> 556
 tctgggaacc ttcaatgtat tactgagacc atgaaccaca aaaataggtt tgagtgaggt     60
 gtgagctaga cctttctgga ggctgaaagc attcacacac acacccctct gctagttaca    120
 tggacacaga ccttgagcca cagcacacgg cagccagtcg agctaggtca caggatgatt    180
 cttacaggac actgatattg atgtatttca caaatgagaa taagttggga atgttagtgc    240
 aatttaatca ccgtaagggt gacttttaaa gatacactga tagttaaaaa aaagacaatt    300
 aaaaaatagc attttgtttt ttaaatggca cccattaaag actcaacagt caaaatgaga    360
 caaatcagtc ctttagacgt tcacagacaa ttgaaaggca ctttaaaaat ccacttttta    420
 aactaccact tgagaacaca tggtagcaca gtcttaaatt catcctagtt gatcgggaat    480
 gatgaatgag tgttggcacc agaaaatcct gcttgcagaa gggggcgcag gtgtcggtcc    540
 acgggacagc cactggccag gctagctgcc gcctcactcc gcagccttct gtggctaaat    600
 ggcaggacgg acacacagga atgggctttg gaccacaagc tctggcatat cgggaggcaa    660
 agcactcaag tactctgcag tctagatgac acatttcatg gtttggagga cagaagtagg    720
 tttccacatc acatgaaaag gacagtgtca cagtggggtt acccagtaaa cagctaccaa    780
 agccatcatt tcacgcttcc ctgtagtttt atgagctcgc cctctgcatg tggatatggg    840
 gaaagccggg catgaagggg tgtgtgaaaa agaacagcct ctgtgactga ctgcagtaag    900
 ctcacaagtt tgtcactgtc agacttagca agtcagcctg caaaggttgt gctgatctct    960
 tggccacact acctactcag gttcccatcc atgcctcctg cctgccccca cccccagccc   1020
 caccagtgag acttctgatt ggaagtctat agacataaga attcaactct gacccatgga   1080
 tgagaggatg aggcaaagaa ccaatgggtt atctagtaaa cgatcaataa ctacctaccc   1140
 acaatgattg tcccaggcca atgtcacaag acgacattac ttccaagaac caagtcatcc   1200
 cttgcttctg cgggcccagt gccacgggta ctgtcctgag tggtttggaa ggtgggtagc   1260
 cgctgataca gggacaggca gatgtgcaga cacttaccac cctggtccac cgatcccacc   1320
 ccatgcttcc acctcccaga gctcttgaga taagacctta agaaggatcc ttgggcttgc   1380
 attaaaacca ctttgctgtc cgtggaggtc tgacaggacc caatagttgt tactacaaaa   1440
 gtgcttttgc aaatagggca agttagaaga aggaggtaat atgaatattc tttagaaaaa   1500
 ctcaaatcca tcggcttatc aatacccaaa gtctgaggct acccagggca caatttggtc   1560
 catggaatgc tgagtggagg aggcagctgg tgtgaggctg cgcctgactc ccaggagcat   1620
 ttagccatcc tttttggctt ggggagtgtc aaagagccgg actgccttcc tgcacagcag   1680
 acagaaccag tagatctgag gagctacgag gaaggcattg gccacgttgc agtagaatgg   1740
 gatgctgaag ggtacttgga gcaggcttag tccctgctgg cggccatagg accagtacat   1800
 gaaggggaag agaaggatcc ggcaggaaag gaaggtggcc agcgtgagga ttccattcac   1860
 cttgtacaga agggtgtgct gctgctttag ctgaatcaga accctgccca gcgacacaaa   1920
 cggagtgctc agttctgccg tgaagatgca gccgacaaag aagtccccaa ggtctccccg   1980
 gagcctctgt gcgactggca caaggacaaa gagaatgacc gcatgatgtg tgatcatgag   2040
 gcggtttcga cttaggaagt ttcgaagagt gagggagggc gcacggttct ggtctctggt   2100
 tcggcaccat tcacagaggt acatggcgta cgagtcatag atcatgtatg gaatcagaaa   2160
 ccacacatat tcccgggcaa gccagtgcct gccggtgatc acgtcgtcgc aggagcgaat   2220
 gatgacgatc cccgagccgg tggccagcac ggcgtgcacc gaggaaacca gcctggtgct   2280
 gatcatcacg cagtcggtgc ggctccatcc gggctgggag cggcgcagcg cgcaggccaa   2340
 agcgcgttgc agcggggtcg at                                            2362



      <210> 557
      <211> 1612
      <212> DNA
      <213> Homo sapiens


      <400> 557
 cccacgcgtc cgcccacgcg tccgggccac acgcctcagc cagccccggc aagggcctat     60
 caggggtggg tcggggcatc cgagcgggtt tgacggaagg agcggcggcg acggaggagg    120
 aggatggagg cggtggtgtt cgtcttctct ctcctcgatt gttgcgcgct catcttcctc    180
 tcggtctact tcataattac attgtctgat ttagaatgtg attacattaa tgctagatca    240
 tgttgctcaa aattaaacaa gtgggtaatt ccagaattga ttggccatac cattgtcact    300
 gtattactgc tcatgtcatt gcactggttc atcttccttc tcaacttacc tgttgccact    360
 tggaatatat atcgatacat tatggtgccg agtggtaaca tgggagtgtt tgatccaaca    420
 gaaatacaca atcgagggca gctgaagtca cacatgaaag aagccatgat caagcttggt    480
 ttccacttgc tctgcttctt catgtatctt tatagtatga tcttagcttt gataaatgac    540
 tgaagctgga gaagccgtgg ttgaagtcag cctacactac agtgcacagt tgaggagcca    600
 gagacttctt aaatcatcct tagaaccgtg accatagcag tatatatttt cctcttggaa    660
 caaaaaacta tttttgctgt atttttacca tataaagtat ttaaaaaaca tgaattgagt    720
 ttctgtagat ttctagttct caactttagc ctgaacgcca acacttgaag gtgtttttca    780
 tcctctgtat gttgaaggtg gttatttgta tgtaggaaca ggactgccat cccagctttg    840
 catgccaaag aaataaagaa cacactttaa agggcaaact gaagagatga gcgagcaaag    900
 gtgcccttca ggtctactga aaagttagag tacaaaacaa cactgttgat ctggacaaaa    960
 gaagaaaaat tacccttttt gcttgtgttg tgacaacttc atttaatatg gtttaaagat   1020
 ttatgagact gtcagctaaa agtcttttca caagaatgtc aacagagaat ggcatctcaa   1080
 aatatatata tttctttgca caatttgtga aaccttataa gccattttcc ccaggtacaa   1140
 tgtagttcct gctgatagaa aggaaatatt ttgtcaagag ctttcattta aaagctacta   1200
 cctccacaat cacccccaaa cccagaaaat ccccactggc tcttgccagt ctggttttcg   1260
 tattgcagtt attccaattg tatttgatct ccctgataac gtattttcat gggtttgggt   1320
 agaagatgct aatcagatta gaagcaggaa tagttatttg ctgtctgtga aattgagcct   1380
 tttggtgcgc cacgtggtgc cagatcaaca cttctatccc tctgcactga ccacgttgtg   1440
 aactgggaga cccaaatgca agccatttca tggacatagc aatatacaac caaactctgt   1500
 tccttggagt tatattgtaa actcttgcag gtgggagagc agttcacctc cttagctctg   1560
 tttgccagct cttacagggt aaaataaacc tgggcaattt atcctcaaaa aa           1612



      <210> 558
      <211> 557
      <212> DNA
      <213> Homo sapiens


      <400> 558
 aaagtttaaa agatttgaac agaaccaagc tatcctggga atggaggtcc aatcacacta     60
 accctcggac taataaaaca tatgttgagg gagacatgtt cttacacagc aggttcatag    120
 gagccagtct tgatgtcaag tgtctggcct ttgttccaag cctgatagcc tttgtgtggt    180
 ttggattctt tatttggttc tttggacgat ttttgaaaaa tgagccacgc atggagaatc    240
 aagacaaaac ttacactcgc atgaaaagaa aatctccatc agaacatagc aaagacatgg    300
 gaatcactcg agaaaacacc caggcttcag tagaagaccc cttgaatgac ccttctttgg    360
 tttgcatcag gtctgacttc aatgagatcg tctacaagtc ttcccaccta acctcggaaa    420
 acttgagctc acagttgaac gaatctacta gtgcaacaga agctgatcaa gacccaacga    480
 cttctaaaag tacacctacg aactagactc ggagatagac ttggagataa cacaaaaagc    540
 aaccttgagt gtaactt                                                   557



      <210> 559
      <211> 3450
      <212> DNA
      <213> Homo sapiens


      <400> 559
 cagggtggtg aactaaaaaa gctggttcct gtgaaccttg ggaaatggtc tcacccctct     60
 gagccctgga gatgacctga tggggcagct aggaggtcca aatggaagga ctgcaaataa    120
 aaggcactgg gaactctcag gggccacaca catgtgagat cttcccaata aaatcagcct    180
 tagctttaaa accaggaaat tgttagcaac aggctctcac cttcctccaa cacccacagc    240
 attgcctatc tccctgtgat agcttgattc taaagataac agcctgcctt tactcagaaa    300
 ccaggactgt gacgtgtttt gcacacattc tcttttcact ttcacagtgt gtgactatgg    360
 catgcaactt atgttctctg tgcctcagtt tactcaagtg ttaaacagga atactcacat    420
 gaggattaca tgagttaaaa tggataaaat ggataaaagt agagagtaaa ttatttaaac    480
 tttatcaaat ccttggtaca tgaccttaat acaattaagt atttgttaaa tacatacatt    540
 ttaaagaaac gtcatcatat ccacacacct atgaggcacc tgcccaggac cacagagcca    600
 atcaatcagg tgatgagtga ttccaggcca gcaggaaacc accgcccact gacacaggga    660
 ctgcaccatc catccttggt ttgcatggtg cctgccatgc ttcctgtatt actgttaaat    720
 acatggggca ggcctttgga ggatcccaat gttttaaaag ggcaatacga atatgattct    780
 aatacataaa aagtatgagg gcagcaagaa tttagttaca aaacccaaaa atcctcaaag    840
 agaagccaca tagcactgtg cagtgttacc actgcctcga gtctggacag ggcacaggtg    900
 accgagacaa gtcttattta actgatttca caagaagggt ccgagtttta ttagacaacc    960
 catgtcaagg tacaaaatga ttaatgacaa tatcagccat attctattag ccaagtgcca   1020
 cctgtcacta tgaaactatc ctgtaggaca tccctgggct ctcagttgct aatgggctgc   1080
 tgaagaaatg aatgtcctca aatcgagacc ctaacacaaa gagattccag agagtggctt   1140
 agaaaaccca gctactctta ccaatgtggg gaaagggtca ggggaatgaa cctctgcagg   1200
 acaatttgaa ttcccaaact gagtaagagc gaaacaaata tgcaggcaag gcaaagcctc   1260
 aggggggctc ctgggtctgg ggcagggggt gggagacagg agaggcaaaa tggcagggac   1320
 ttgacagcag gttcctcttg tctacttctt cctcccgcct ctctccttga gggccaggtg   1380
 gatgactgcg ccattggcca tgttgtagta agccagtgag ttggaatctt tgatgaagat   1440
 accctcatac tgtagcttct gtttccctgc aggcatgcct gtggcttcat gaatcttcac   1500
 cttaatgaca gagacctggt ccgtgagtgg gagggtgaag accagcacct gcccattcag   1560
 tttccattcc gtcttatcct gcatgttggg cacctggact ttgatggaca ctggaccctt   1620
 gtttctgcgc aggaactcct cctctggcat gaggctgtcc tctgtcttca gttttttgga   1680
 ggtgggctca tcttccatgg gaggtggggg atgcacaggg ggcattgggg ctggagctgg   1740
 gacaggtgcc acaggtggag caggcacaaa ggctgttggc acaatcatgg ggggtgggcg   1800
 gggggccata ataggagggg ccgagggagg catgggcacc acgttgattc tgggcgcgtg   1860
 gatgatgggc ggcatggggg cgatcactga gcctgggggc agccggacca cagatgccat   1920
 tgggggccgg ggcatgacgg gtactgcgga gacaactgta gtacgaactg gaggtggcat   1980
 tgtgggtggt cggggcactg aagtgatggg tggagccgag ctggggatgt tggtggctga   2040
 agatggtggc ggtggctgtt gagggatttc attgggcttg ctggggccaa tcttctcttt   2100
 agtgtcatcc tctggcacca ggcctttggc cttgtgaatg gcctcaatct gctcctggag   2160
 ggtgatgttg gcctgggcag cctgctgggt ccgggccatg ctgcctgagt ggccatccca   2220
 ggtcaccttt tcctctggct tctggatctc ctcctcaccg atcttcttac caatggctgt   2280
 ttcctctaca ccgaagatgt cagtacgccg ctcagccaac tgcttcaagc tgctctcaat   2340
 atccagacct ggtgcgtaca cctcatcatc gctctgcttc tcacggatgg agcgatcccg   2400
 ctgctccagc cagcgagggt caagaagtcc aatgcgcatg tgttcctgca ttttgctggc   2460
 ggggatcttc tccccagtaa tgggggacac aagatactca tctggagcag gggctggagg   2520
 caagggcttg gaggctttgg gatcataatc cttgcggaca atgacttggt ctggagttgg   2580
 gggcagaggt ggaggcatgg gtgtctctgg gggtgggggc actttctgcc cttcttcttc   2640
 atcatctgaa ccctcatcca tatcttgtac ttgggtgtcc tggtccagct gggaaggagg   2700
 ctcctccgcc ttctcctgtt tgtcatcctc ctcatcagac tcgacctcca tctcaacttc   2760
 ctcactctcc ccaaactttt catagcgctc ctgaatgagg attcgggccc ccagctcctc   2820
 tggcgtggtg gggggaggga agttcccttg ctcattgggt tggaagtcca ctgtttccac   2880
 caccacaaaa tcatgccagt cgatctgagc ataggccacc cgctccttct ccttctcctc   2940
 ttcttccttc ttcctctcac gttcctggaa tttggcccat tccactcggt aacacacctg   3000
 atccaaaact tctcgggggt tttcagcctc tttcttgagc tttgaaaata aacctttggg   3060
 tggaatcaag atcttggtgt actgttccac tagcttcgtg aagtagttga agaggctgtg   3120
 ctgtgggcgg agaaagtcaa actggtagtt gcgctgctct ttctgcatca gctgggtcag   3180
 aaactggcgc ccattcctgg ccacaaattg agccgtcagc ttcaccacat ccaagtcgaa   3240
 ggctgagata gagggaggat cagcaatgaa ctcaaactca ggaggaggct ctttgggcac   3300
 gatggtctct tggattactt gggcttggac cttctggggc agctgctgct gggtggtctg   3360
 ctgctgctgc tgcatgacct tggggatggc ggcggacggc tcctgagcct tcccttcctt   3420
 gaactcgctg accttgtggc ggtagtaggc                                    3450



      <210> 560
      <211> 925
      <212> DNA
      <213> Homo sapiens


      <400> 560
 ggctcgccgg gaccagatcc gcgagcccgt cagcctgcgc catgggctgc gacggccgcg     60
 tgtcggggct gctccgccgc aacctgcagc ccacgctcac ctactggagc gtcttcttca    120
 gcttcggcct gtgcatcgcc ttcctggggc ccacgctgct ggacctgcgc tgtcagacgc    180
 acagctcgct gccccagatc tcctgggtct tcttctcgca gcagctctgc ctcctgctgg    240
 gcagcgccct cgggggcgtc ttcaaaagga ccctggccca gtcactatgg gccctgttca    300
 cctcctctct ggccatctcc ctggtgtttg ccgtcatccc cttctgccgc gacgtgaagg    360
 tgctggcctc agtcatggcg ctggcgggct tggccatggg ctgcatcgac accgtggcca    420
 acatgcagct ggtaaggatg taccagaagg actcggccgt cttcctccag gtgctccatt    480
 tcttcgtggg ctttggtgct ctgctgagcc cccttattgc tgaccctttc ctgtctgagg    540
 ccaactgctt gcctgccaat agcacgggcc aacaccacct cccgagggcc acctgttcca    600
 tgtctccagg gtgctggggc cagcaccacg tagatgccca ggccttggtc caaccagacg    660
 ttcccaaggc tgactcccaa ggaccgggca gggaacccga ggggcctatg ccttctggat    720
 aatggccctt attaatcttt ccaaggccca tggctgggct tgaagctgct ggccccaggg    780
 aacggcttgt tggaactgct cgtcccccac agggggcccc ccgcttcctg gactgggaaa    840
 gaaacttgcc tttgaaaaca ccagccctct tggaagaaga agacaaacct ccctcaaaag    900
 gcctatagtt tatactaacg cctac                                          925



      <210> 561
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 561
 ccagatccat tttcacttat tggagagagc acgatttatt gtggtgacaa ttcagtgtgg     60
 agtcgtgctg ctccagagtg taaagtggtc aaatgtcgat ttccagtagt cgaaaatgga    120
 aaacagatat caggatttgg aaaaaaattt tactacaaag caacagttat gtttgaatgc    180
 gataagggtt tttacctcga tggcagcgac acaattgtct gtgacagtaa cagtacttgg    240
 gatcccccag ttccaaagtg tcttaaaggt cctaggccta cttacaagcc tccagtctca    300
 aattatccag gatatcctaa acctgaggaa ggaatacttg acagtttgga tgtttgggtc    360
 attgctgtga ttgttattgc catagttgtt ggagttgcag taatttgtgt t             411



      <210> 562
      <211> 702
      <212> DNA
      <213> Homo sapiens


      <400> 562
 atttacagat agccttggat gccagttact ggactttcat taatcacgtc ttcatctggg     60
 ggagcattgc catttatttc tccattttat ttacaatgca cagtaatggc atctttggca    120
 tcttcccaaa ccagtttcca tttgttggta atgcacgaca ttccctgacc cagaagtgca    180
 tctggcttgt aattctctta acaacagtgg cttcagttat gccagtggtg gcattcagat    240
 ttttgaaggt ggatttatac ccaaccctga gtgatcagat ccgccggtgg cagaaggctc    300
 aaaagaaggc aaggcctcca agtagccgaa ggcctcggac ccgcaggtca agctcaagaa    360
 ggtctggata tgcttttgct caccaagaag gctatggaga gcttatcaca tctggaaaaa    420
 atatgcgagc taaaaatcca cccccaacat cagggctgga aaagacacat tataatagca    480
 ctagctggat tgaaaattta tgtaagaaaa ccacagacac cgtgagcagc tttagccagg    540
 ataaaacagt gaaactgtga gtcaatatga atttaaacca cgtagttatc ttttcacttc    600
 aggtggagct gaaattctgc tggctccaga gtttgagatt tgaggcaaga ggtggggcag    660
 gcagattgcc tcacttaact taaatctgcg gcagacaact gc                       702



      <210> 563
      <211> 912
      <212> DNA
      <213> Homo sapiens


      <400> 563
 ccaggagcca agagcagagc gccagcatga acttgggggt cagcatgctg aggatcctct     60
 tcctcctgga tgtaggagga gctcaagtgc tggcaacagg caagacccct ggggctgaaa    120
 ttgatttcaa gtacgccctc atcgggactg ctgtgggtgt cgccatatct gctggcttcc    180
 tggccctgaa gatctgcatg atcaggaggc acttatttga cgacgactct tccgacctga    240
 aaagcacgcc tgggggcctc agtggtgagg gatgtggtgc tcgggcctgg ctctgcccca    300
 cccagcgagg caccgagggc cactctgtga tgctggctac agcaagaatg aacccacagg    360
 cgcagagccc aacaggctgt aaaggaaggc agtgacctct gcatgtttct gtctctctca    420
 ctaacccttt gcctctgttt ctctttcttc tgtctctatc tctctctggc tctctatttg    480
 ggttcctttt tctgtctccc tttccatgtc tctgtctttc tgtgtctctt tccctctgta    540
 cttttccttt cagttgctct tggcagtcct gagaatcaca tttcctggag aaaggtggga    600
 gaggaactaa aattggcttc acacagaaat ttctgttctc tcatgcaaaa gatgagatca    660
 aataaaccca gtcccagtag gccacgaggt tgggcctaag tgtgggcgga tgggggaagg    720
 tctggttaca ctgcctttga ggcccacgac gaaatttttc tcttaattgt ggaaaggcct    780
 ttcccaagga ggactggata ggccctcgag aaaaactgac ctggctgacg gccccgtggc    840
 caagccttgg cctccctgga ccccaagggc cagattgaat tcatcccttt tttaggggta    900
 agcctcagcc gg                                                        912



      <210> 564
      <211> 1404
      <212> DNA
      <213> Homo sapiens


      <400> 564
 cggcgggcgg tggctttggg gccgaagtgg gcgtgcggct cgcgctgttc gcggccttcc     60
 tggtgacgga gctgctcccc ccgttccaga gactcatcca gccggaggag atgtggctct    120
 accggaaccc ctacgtggag gcggagtatt tccccaccaa gccgatgttt gttattgcat    180
 ttctctctcc actgtctctg atcttcctgg ccaaatttct caagaaggca gacacaagag    240
 acagcagaca agcctgcctg gctgccagcc ttgccctggc tctgaatggc gtctttacca    300
 acacaataaa actgatcgta gggaggccac gcccagattt cttctaccgc tgcttccctg    360
 atgggctagc ccattctgac ttgatgtgta caggggataa ggacgtggtg aatgagggcc    420
 gaaagagctt ccccagtgga cattcttcct ttgcatttgc tggtctggcc tttgcgtcct    480
 tctacctggc agggaagtta cactgcttca caccacaagg ccgtgggaaa tcttggaggt    540
 tctgtgcctt tctgtcacct ctactttttg cagctgtgat tgcactgtcc cgcacatgtg    600
 actacaagca tcactggcaa ggacccttta aatggtgaaa atgggcagat gaatagcaat    660
 aagtggacct ttgttactct tctgagttag aaaaattcta atttagtaca ctctgaacaa    720
 agcttattat acttacttaa gatgtgtttt gatttggtgt tcagaaagca acctgacaat    780
 gataatactg taactatgat aaaattgaga ataaaaagat tttatttaga aatcataagt    840
 ctggaattga ggttatttta gccccacagt agagtatcct ggagggccag gtcctctatg    900
 ctatgtgtat gtaataggat ttaggagcct aatattaaga gaagaccttg tttccactct    960
 cttcagatgt actagttgga tccatgattg gaatgacatt tgcctatgtc tgctatcggc   1020
 agtattatcc tcctctgact gatgcagaat gccataaacc atttcaagac aaacttgtac   1080
 tttccactgc acagaagcct ggggattctt attgttttga tatttaaaaa ttgaatctgg   1140
 ccgggcgtgg tggctcatgc ctgtaatccc aacactttgg gaggctgagg agggtggatc   1200
 acctgaggtc aggaccagcc tggccaacat ggggaaccct gtctctacta aaaatacaaa   1260
 aattagccag gagttgtgtg ccgtaatccc agctacctgg gaggctgagg taggagaatt   1320
 gcttgaacct gggagctgga ggttccagtg agccgagatc gcaccactgc actccagcct   1380
 aggcaacaga gtgagacccc gtct                                          1404



      <210> 565
      <211> 406
      <212> DNA
      <213> Homo sapiens


      <400> 565
 ggcattatta ttgggaccat cttcatcatc aagggagtgc gcagaagcaa tgcatcagaa     60
 cgcagggggc ctctgtaagg cacatggagg tgatggtgtt tcttacagag aagatcactg    120
 aagaaacttc tgctttaatg actttacaaa gctggcaata ttacaatcct tgacctcagt    180
 gaaagcagcc atcttcagcg ttttccagcc ctatagccac cccaagtgtg gttatgcctc    240
 ctcgattgct ccgtactcta acatctagct ggcttccctg tctattgcct tttcctgtat    300
 ctattttcct ctatttccta tcattttatt atcaccatgc aatgcctctg gaataaaaca    360
 tacaggagtc tgtctctgct atggaatgcc ccatggggca tctctt                   406



      <210> 566
      <211> 596
      <212> DNA
      <213> Homo sapiens


      <400> 566
 tcctcaagtc acgggtccac ccacgcgtcc gtgtaaacga aaagcttcat aagtccctct     60
 ttgcttagta cttttctcgt cctttcccca gggtgcacgt aaccctcaag cactaggacc    120
 gtgcggaatc caggctgcga tggcaccttc atttaccgcc cgcattcagt tgttcctctt    180
 gcgggcgcta ggctttctca taggcttagt aggccgagca gctttagtct tagggggtcc    240
 aaagtttgcc tcaaagaccc ctcggccggt gactgaacca ttgcttctgc tttcggggat    300
 gcagctggcc aagctgatcc gacagagaaa ggtgaaatgt atagatgttg ttcaggctta    360
 tatcaacaga atcaaggacg tgaacccaat gatcaatgga attgtcaagt acaggtttga    420
 ggaagcgatg aaggaggctc atgctgtaga tcaaaagctt gcagagaagc aggaagatga    480
 agccaccctg gaaaataaat ggcccttcct tggggttcct ttgacagtca aggaagcttt    540
 ccagctacaa ggaaatgcca attcttctgg actcatgaac cgtcgtgatg ccattg        596



      <210> 567
      <211> 339
      <212> DNA
      <213> Homo sapiens


      <400> 567
 cccacgcgtc cgcccacgcg tccggccagc aatccttcta ccattacact ctttctccca     60
 atattatctg cattggccga agccattcat gtgaaccctc tttatattct gataccttct    120
 actctgtgta cttcatttgc attcctccta ccagtagcaa atccacccaa tgctattgtc    180
 ttttcatatg gtcatctgaa agtcattgac atggttaaag ctggacttgg tgtcaacatt    240
 gatggtgttg ctgtggttat gcttggcata tgtacttgga ttgtacccat gtttgacctc    300
 tacacttacc cttcgtgggc tcctgctatg agtaatgag                           339



      <210> 568
      <211> 492
      <212> DNA
      <213> Homo sapiens


      <400> 568
 ctccgcttga ggagaagcgc caagtgcgca tggggacgct atagcaattc gtttgctgtc     60
 cttcctctcc ttcgaagatg acaaggccta ccatcgtttc ttcctgcctt tgggccgtca    120
 ggcagttggt tgggacccgc tccaaccctc ggttcttcct gcaatacagt ggatacaatt    180
 tgtcatggct actctgagat aagaccactt ttttatctga gcttctgtga cctgctcctg    240
 ggactttgct ggctcacgga gacacttctc tatggagctt cagtagcaaa taaggacatc    300
 atctgctata acctacaagc agttggacag atattctaca tttcctcatt tctctacacc    360
 gtcaattaca tctggtattt gtacacagag ctgaggatga aacacaccca gagtggacag    420
 agcacatctc cactggtgat agattatact tgtcgagttt gtcaaatggc ctttgttttc    480
 tcaagcctga ta                                                        492



      <210> 569
      <211> 388
      <212> DNA
      <213> Homo sapiens


      <400> 569
 gtctgccctc acctccccct gcagcctggg atgggtcagg gaatggggat ggtgggggat     60
 ctaaggtccc ctcgacccac atgccctctc cctctgcccc agctcacact ggtggtggtc    120
 caggtcagca tcctctacta cgggggccac cttgtcatct caggccagat gaccagcggc    180
 aacctcatcg ccttcatcat ctacgagttt gtcctgggag attgtatgga gtccgtgggc    240
 tccgtctaca gtggcctgat gcagggagtg ggggctgctg ataatgtgtt cgagttcatc    300
 gaccggcagc cgaccatggt gcacgatggc agcttggccc ccgaccacct ggagggccgg    360
 ggggactttg agaatgggac cctcaccc                                       388



      <210> 570
      <211> 669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(669)
      <223> n = a,t,c or g


      <400> 570
 gattacgcca agcttggcac gaggggcagc gcctggcccg ggcgcgcaaa gctgctcttc     60
 tcgcactcgg ggctctggcg catctgcgaa gtgctgcacc gtgcagtcat tgtggtcctg    120
 cccctgagcc tggtccttct cgtgtgtggc tggatctgcg gcctgctcag ctccctggcc    180
 cagagcgtgt ctctgctgct tttcaccggc tgctacttcc tgctggggag tgtcctgaca    240
 ctggcggggg tcagcatcta catcagctac tcgcacctgg cctttgcgga gacggtgcag    300
 cagtatggcc cgcagcacat gcagggcgtc cgcgtcagct tcggctgggc catgggcctg    360
 gcctggggct cctgtgcctt ggaggcattc agcggaaccc tcctgctctc agctgcctgg    420
 accctcagcc tgagcccccc aatctgtggt catctgagtc cccagcaggt gggagggaga    480
 gggggagact gaggcccaga gcggcagagg gacccaccca gatcgcctgg cgccagagag    540
 atgccgtctc aggccaaggc ctccctggcc tctgttctgt ccactctccc cgaagggcag    600
 gcttggtgga gaagaggctg atgagagggc ccgagagccc cttcgatttg cannnnnnnn    660
 nnncaaggg                                                            669



      <210> 571
      <211> 1730
      <212> DNA
      <213> Homo sapiens


      <400> 571
 cggacttccc gggtcgacta cagcatcggc ggcggcggct agtgccgcta gcgcctcgag     60
 cgatgcacct cctttccaac tgggcaaacc ccgcttccag cagacgtcct tctatggccg    120
 cttcaggcac ttcttggata tcatcgaccc tcgcacactc tttgtcactg agagacgtct    180
 cagagaggct gtgcagctgc tggaggacta taagcatggg accctgcgcc cgggggtcac    240
 caatgaacag ctctggagtg cacagaaaat caagcaggct attctacatc cggacaccaa    300
 tgagaagatc ttcatgccat ttagaatgtc aggttatatt ccttttggga cgccaattgt    360
 agtcggtctt ctcttgccca accagacact ggcatccact gtcttctggc agtggctgaa    420
 ccagagccac aatgcctgtg tcaactatgc aaaccgcaat gcgaccaagc cttcacctgc    480
 atccaagttc atccagggat acctgggagc tgtcatcagc gccgtctcca ttgctgtggg    540
 ccttaatgtc ctggttcaga aagccaacaa gttcacccca gccacccgcc ttctcatcca    600
 gaggtttgtg ccgttccctg ctgtagcaag tgccaatatc tgcaatgtgg tcctgatgcg    660
 gtacggggag ctggaggaag ggattgatgt cctggacagc gatggcaacc tcgtgggctc    720
 ctccaagatc gcagcccgac acgccctgct ggagcacggc gctgacgcga gtggtcctgc    780
 ccatgcccat cctggtgcta cccccgatcg tcatgtccat gctggagaag aaggctctcc    840
 tgcaggcacg cccccggctg ctcctccctg tgcaaagcct cgtgtgcctg gcagccttcg    900
 gcctggccct gccgctggcc atcagcctct tcccgcaaat gtcagagatt gaaacatccc    960
 aattagagcc ggagattagc ccaggccacg agcagccgga cagtggtgta caacaagggg   1020
 ttgtgagtgt ggtcagcggc ctggggacgg agcactgtgc agccggggag ctgaggggca   1080
 gggccgtaga ctcacggctg cacctgcagg gagcagcacg ccaaccccag cagtcctggg   1140
 ccccctggga gagtgctcaa cctacagtgg agggagactg acccattcac attttaacat   1200
 aggcaagagg agttctaaca catttcgtac aaaaaaataa tcaagtgcat ttctgggcct   1260
 tatgtggggt tgtcaaaact ccactcagca caattatgtg tgaagctgaa aaattgtaga   1320
 gtgcccatgg ggtagaagta gaatcctttt atactttggt tcctttttta tttttatttt   1380
 ttatcagaat caaatctgag ccttagtttc agctgaccag aagtggcagg aggacaggtg   1440
 gaggcgagcc agattaggcc tggagttggg ctggtttggt ggccaggctg gtaaatttag   1500
 gatattacaa tggccagccc agatggctcc ctgggctggc atggggaggg gagagaaggt   1560
 ggtctgcacc ccacaggatg aactagccat gactagggtc ctcaggcagt ggcccaggga   1620
 atcagggagc actggaggcc tctgcaagat tctgtgggca gctggctctg aatgtagcca   1680
 gcccacatcc attccagagc tgcagaacca cgccctctga gtggaagccg              1730



      <210> 572
      <211> 1016
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1016)
      <223> n = a,t,c or g


      <400> 572
 ccaagttgat ttanagaaag cggcctgagc gatagtccag ccggagcttg caggaggtgg     60
 tagacgntgg gagactgagt ttaaagtcat acttttggtt ggaacaaggg ccccaggcat    120
 tgcccatcat gttccggaac cactgcacag tcttgcacac gtctaggtgg aagccggtgc    180
 agagagctgc cttgatggag ctactacact tccccaagac tgccgagggg tcccttgtgg    240
 tggtgcacca ggcacagcac ngtcccctag gagtttctca cgcttgcaca cacattctga    300
 ctccaccagc acacagccac agcggcgnnc cagggctggg tccctcatct ccaggacaaa    360
 catggtgcct gtggggggac aatgggcacc aggatatcaa atttctgggt ctcatggagg    420
 gttccccatt tctcaaaggc agccccgatg cccaggcagt cttcccaatt gtgggtgaac    480
 ctcttggcgg ctgagcaccc gaacaggcct caatgagatc atccacaaaa ctctccacaa    540
 actcacaggt gcagggcagg tcacggatgg cattttggac atagtgtttg taaaaggagt    600
 cccagggcct cctgggaggg gaagtcagta agccagttgt aagaggtgac agggacaaca    660
 cggacttcct cctcctcctc ctcactgctg gaatcaaagg ccggttcatg ctgcatgttc    720
 tgtcgcagga gctcaaagac gagaaaaagg caaaagaggc cagtgttcca caggtttccc    780
 agcatccagc ccagaggccc ttcctggcca tcggcctgga acggccaccc catgtctttc    840
 ttccccagca ctaactggtc actggatgtg tctcctgtcc agaagttctc tgccttctgc    900
 ctctgctcag cggctcgctt tctctcttca aactccatct ctagcaggcg catctcctca    960
 ctcattcgct tctccagctg ccgactcctg gataatgtgt ccaggtccat ccgatc       1016



      <210> 573
      <211> 943
      <212> DNA
      <213> Homo sapiens


      <400> 573
 gcggccgccg cgctccgagg tccccgggcc tctgtctccc gggcgtcctc cagcagcggg     60
 ccttcggggc cggtagccgg ctggagtacg gggccttcgg gagccgcgcg ccttctccgg    120
 cgtccgggtc gagcgcagat ccctgtttat tgggaaggat atgttcgatt cttaaatacg    180
 ccatctgaca aatcagaaga tggaaggcta atttatactg gcaatatggc ccgagcagtg    240
 tttggtaagt aattggaggt gtgaaatgtt tctcttattc tacgagtctg attggcctta    300
 catttctgcc atacattttt acacaaaata atgctatttc tgaaagtgtg cctctgccta    360
 ttcaaatcat attctatggc atcatgggaa gctttacggt gatcacccca gtgctgcttc    420
 actttattac aaaaggctat gtcattcgat tgtaccatga ggccacaaca gacacttata    480
 aagccattac ctacaatgct atgcttgcag aaacgagtac agtgtttcac cagaatgatg    540
 tgaagattcc agatgctaaa catgtattta ccacatttta atgctaaaac aaaatcactg    600
 ttagttaatc cagtgctctt tccaaaccgt gaagactata tccatctaat gggttatgac    660
 aaagaagaat ttattttgta tatgggaagg aaaccagtga agagaaacgg ccattaaagg    720
 tggacaaatg gaggcctatt tgtttagtgt tcgtgcttta aatgtgattt acgttttaat    780
 gtataataat aaaattgcct tttgcattcc gttagtgact gattgttaaa aataatttga    840
 aattatcaaa gcttttaatt tccagagaat gatgtttgtt tataataaaa caagctatgt    900
 ttggaaacca aaatgtagta tctaccattc gtgttttaga aag                      943



      <210> 574
      <211> 453
      <212> DNA
      <213> Homo sapiens


      <400> 574
 gtcgtggaat tcggtcgtgg agactcttca caggctgctg tgtgaatccc aggaaaatct     60
 ttcccagagg ccacagctgc cgtttcttct acgtcctcgg ccagatcact ctgagctcat    120
 tggtggctcc agtgatgtgg ctttctgtgg ctctgctcaa tggaactttc tatgaatgtg    180
 ccatgagcgg gacgagaagt tcaggactcc tggaactgat ttgcaagggt aagcccaaag    240
 agtgctggga agaacttcac aaagtatctt gtggcaaaac tagcatgcta cctaccgtca    300
 atgaagaact gaaactctcc cttcaggccc agtctcagat tctaggatgg tgcctgattt    360
 gttcagcgtc tttcttctct ctgctcacca catgttatgc tcgctgccga tctaaagtta    420
 gctaccttca gctgagtttt tggaagacat atg                                 453



      <210> 575
      <211> 1612
      <212> DNA
      <213> Homo sapiens


      <400> 575
 cccacgcgtc cgcccacgcg tccgggccac acgcctcagc cagccccggc aagggcctat     60
 caggggtggg tcggggcatc cgagcgggtt tgacggaagg agcggcggcg acggaggagg    120
 aggatggagg cggtggtgtt cgtcttctct ctcctcgatt gttgcgcgct catcttcctc    180
 tcggtctact tcataattac attgtctgat ttagaatgtg attacattaa tgctagatca    240
 tgttgctcaa aattaaacaa gtgggtaatt ccagaattga ttggccatac cattgtcact    300
 gtattactgc tcatgtcatt gcactggttc atcttccttc tcaacttacc tgttgccact    360
 tggaatatat atcgatacat tatggtgccg agtggtaaca tgggagtgtt tgatccaaca    420
 gaaatacaca atcgagggca gctgaagtca cacatgaaag aagccatgat caagcttggt    480
 ttccacttgc tctgcttctt catgtatctt tatagtatga tcttagcttt gataaatgac    540
 tgaagctgga gaagccgtgg ttgaagtcag cctacactac agtgcacagt tgaggagcca    600
 gagacttctt aaatcatcct tagaaccgtg accatagcag tatatatttt cctcttggaa    660
 caaaaaacta tttttgctgt atttttacca tataaagtat ttaaaaaaca tgaattgagt    720
 ttctgtagat ttctagttct caactttagc ctgaacgcca acacttgaag gtgtttttca    780
 tcctctgtat gttgaaggtg gttatttgta tgtaggaaca ggactgccat cccagctttg    840
 catgccaaag aaataaagaa cacactttaa agggcaaact gaagagatga gcgagcaaag    900
 gtgcccttca ggtctactga aaagttagag tacaaaacaa cactgttgat ctggacaaaa    960
 gaagaaaaat tacccttttt gcttgtgttg tgacaacttc atttaatatg gtttaaagat   1020
 ttatgagact gtcagctaaa agtcttttca caagaatgtc aacagagaat ggcatctcaa   1080
 aatatatata tttctttgca caatttgtga aaccttataa gccattttcc ccaggtacaa   1140
 tgtagttcct gctgatagaa aggaaatatt ttgtcaagag ctttcattta aaagctacta   1200
 cctccacaat cacccccaaa cccagaaaat ccccactggc tcttgccagt ctggttttcg   1260
 tattgcagtt attccaattg tatttgatct ccctgataac gtattttcat gggtttgggt   1320
 agaagatgct aatcagatta gaagcaggaa tagttatttg ctgtctgtga aattgagcct   1380
 tttggtgcgc cacgtggtgc cagatcaaca cttctatccc tctgcactga ccacgttgtg   1440
 aactgggaga cccaaatgca agccatttca tggacatagc aatatacaac caaactctgt   1500
 tccttggagt tatattgtaa actcttgcag gtgggagagc agttcacctc cttagctctg   1560
 tttgccagct cttacagggt aaaataaacc tgggcaattt atcctcaaaa aa           1612



      <210> 576
      <211> 4376
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(4376)
      <223> n = a,t,c or g


      <400> 576
 atgagtgcag actggctgat cgggaaagcg aggagccgcg gcggcgtgga gccggcgggc     60
 ccgggcgggg gctccccgga gccctaccac cccaccctgg gcatctacgc ccgctgcatc    120
 cggaacccag gggtgcagca cttccagcgg gacacgctgt gcgggcccta cgccgagagc    180
 ttcggcgaga tcgccagcgg cttctggcag gccacagcta ttttcctggc tgtgggaatc    240
 tttattctct gcatggtggc cttggtgtcc gtcttcacca tgtgtgtaca gagcatcatg    300
 aagaaaagca tcttcaatgt ctgtgggctg ttgcaaggaa ttgcaggtct attccttatc    360
 ctcggtttga tactctaccc tgctggctgg ggttgccaga aggccataga ctactgtgga    420
 cattatgcat ctgcctacaa acctggagac tgctccttgg gctgggcctt ttataccgcc    480
 attgggggca cagtcctcac tttcatctgt gctgtcttct ctgcacaagc agaaattgca    540
 acctctagtg acaaagtaca ggaagaaatt gaagagggga aaaacctgat ctgcctcctt    600
 tagtttggaa gagacaatgc cattttctcc cttgagtaat cttgtgaaac agtccacagt    660
 ttcatcattt gagtcaagtg gagaactaac ctttacctac caaagccacg ttccacggcc    720
 cgaggcttaa acaggaccaa tgagaggcca catccagcta cgcaaagtta ctggacatgc    780
 ggtctgcagt gcacattata aggaatggaa catgaaaata gtatataatc ctagacctgg    840
 agttgccaag ttctgtcaga ctccatctcc cccaggttca atgatggatg ataatctaaa    900
 tcattagggc agcagtttct ctggtaacgg aagagaccgt ccgccagatc tgcaggctgt    960
 ttctgctcca acactgcttg cttgtgagca tctctgcctc agaatggggt tttgggttgg   1020
 agttcttgtt ttcctctgtt ctttcaagtt gtctccaacg aacagaaaac tataaactta   1080
 ctgggggaca ggatggtgtg ctaaaagggc acagcaagac actgtctttt tgcttagctg   1140
 accaaagggg tcagcaggga tggcgtggag tcatgctgtg gaacttattc taggctgaat   1200
 cctagggtaa ggtggatcaa ctgaactgtc actccagaga ttttagaaat ttgagtaaag   1260
 aaacaataag gacctataca atcatatgag aacaaaaata tgaaatcttg ctagtgaaga   1320
 cgtatttttt cttcttccca gcagccaggc tagcaccagt tctggcccag tctcctcttc   1380
 ttctggagat cacatgtttt tcttctaagg ttaggattgt gctttgactg cgaaaggaaa   1440
 cctcactgtt tcctccttcc agggactgag ggtctccaag ctagctgtgg cttatgcaga   1500
 tgttcactgg gaggacctgc cagaatctcg gcacttgggg ggagaccttt actcccagtt   1560
 tggtgaccat gctgtagtca gctctatttc caatcccgac agtagcagaa tggcattcta   1620
 caacaaaaag aagctagtta tgggagttaa gtttttgtag ttactggtgt tgatcctgaa   1680
 agcagactga gataacatta aattgctgca actgaagaac tgcagccaag accttaattc   1740
 caggaaagca cagaggacaa agttaattca aaaagaggcg ctagatcaag gtcacagcac   1800
 ttccctacac ctgtttacat aaagaatcaa ataccactat gaataaggat tcaggggttt   1860
 ttaatctact ttccataaat taccaatatc actgattcag gaagatagta tctcagaatg   1920
 accagagcag cacagaaaca agctactctg acattatggg agcttcaaaa ttgtatcatg   1980
 atacagaaac actccttagc actttaagaa agtgagatgg aactgccaga tttctggaag   2040
 gagaaaaagt gtaggtattt gggttcatta atctgctcac ttgaggactt tgttttgaaa   2100
 aagtaccttc tgtggacaag gtattgtgct accagctata caaccctgac ttcagagttt   2160
 gcaaccttgc cctgagtgaa tcatgttaaa gctgtctgag tctaaagcac cgtatcttgg   2220
 tgcagaacag ataattatag agagatggaa tgggacaacc gcagttttac tacattctgg   2280
 tgtttggcct atatgagaaa ccatcttctc acagattaag ggctaagggc aaaaggggtg   2340
 ggaggtgtgg aactagcctt aatgagtttc ccattcctga accaaaattc aaagtgagtg   2400
 agatgtaaat cctgtgattt tggtgaagaa aaaaacgggt atcttcatag cagcctagga   2460
 aaccttaacc atatctctaa caccacacag aaagaggctg gaggagccac tggacaaagc   2520
 ttctgtctct gtgtgtacat ttataatgtt ctaaccaagt ctcaaacctt gatgaaaaac   2580
 acaaaatttt tccataaact tatcagaaga ctcacttttc tttctttctt ggatagagaa   2640
 accattttct gacactaggt ttacaatctc agtgtcctta caagttaagt cctaagctca   2700
 caggatcctc cgagcatgtc catcacctgg ctctttggct aaagggtggc agtgtacctc   2760
 ctagatcaac ctggggaaca gtcacaaggg agtgtgactt cttggccata ataaactcac   2820
 tcgatagtgt ttatgttatt aatctgaatg caacagaaga caaaagcaca ggcatgcaca   2880
 cacacacaac cccaaaccac taaaaactac ctaaacgact gacttagtaa atagtaaaaa   2940
 ggtaatgttg ggacttttaa accttgaatc cattagccag gcttgggaat gaaaggacca   3000
 tctaaaatca tgctagtcta aaccatgctc ttccacacag ctgtttaaaa accactgggt   3060
 atgaggaata tgcctagaaa gaaatgttaa aaatagattg ttggctcaca cttatttttc   3120
 ctaataaata gggcccatta ttactaccag gaaagtctta tttattttgc ctgaaattgg   3180
 cttaaagacc agtctcatga cgggatggga tgggctgcgc ttctcaatga actctgaggc   3240
 agaaatattt gccttgggat tctgtgggat tctttaaacc tgtgtgctaa taattcaaac   3300
 aatgttgcat taattgtata agggtttttg gtatagtttt caaacatctg tggtgtaatg   3360
 atctttgtta aacatatatt ctgtaaagtg ccatagtctt tttttatgtg tagcatattt   3420
 taaaaatata tatgtatatt tatacataca caagtttggt gtggaaagat gtgcaataac   3480
 aaaggggtat gtatgttttg ttgttttgtt ttggaaactg gacaggagtc aaaacaggga   3540
 tgtttgtttc tgttttggca aaggagagtt ccacattttt gccttcatgg cttattcagt   3600
 aacccataat tttaatgcta cacaaatctt atgtgaagaa aagactggta tgaaatcatg   3660
 ttttcctggg tctagaataa tcgctagtgt tatgtcaaag ttaagcccgc acgccaggcc   3720
 ccagtaatgc tagtctttcc atgtgaaatg tgaagctgcc atgttgcctt ttctcttagt   3780
 aggataacta gtagctggta ccataatcac tgaggagcta tttcttaaca tgctttttat   3840
 agacccatgc taatgctgga cccagtattt aagggctaat ctcacacctt ccttagctgt   3900
 aaggagtctg gcttagaaac agacctcctc tgtgccaata acttgtggcc cactgggaaa   3960
 tcccctgggc cgggcatttg tantttgggg gttgcaatga ctccccaagg gccaaaaaga   4020
 gttaaaaggc acgacttggg agtttctttc tgagactgtg gttgaaactc cttcacaagg   4080
 ctgagggggt cagtaggtgc tctggaggga ctcgggcaca actttgatat caacagccac   4140
 ttgagccaaa tataaaattg tatttacagc tgatggactc aatttgagcc ttcaaacttg   4200
 tagttatcct attatattgt aaactaatac attgtctaag cattgatttg gttcctgtgc   4260
 atatgtattt acagctgatg gactcaattt gagccttcaa acttgtagtt atcctattat   4320
 attgtaaact aatacattgt ctagcattga tttggttcct gtgcatatgt attttc       4376



      <210> 577
      <211> 599
      <212> DNA
      <213> Homo sapiens


      <400> 577
 tttcgtggcg ggttccgcac ggaggttgtg acccctacgg agccccagct tgcccacgca     60
 ccccactcgg cgtcgcgcgg cgtgccctgc ttgtcacagg tgggaggctg gaactatcag    120
 gctgaaaaac agagtgggta ctctcttctg ggaagctggc aacaaatgga tgatgtgata    180
 tatgcattcc aggggaaggg aaattgtggt gcttctgaac ccatggtcaa ttaacgaggc    240
 agtttctagc tactgcacgt acttcataaa gcaggactct aaaagctttg gaatcatggt    300
 gtcatggaaa gggatttact ttatactgac tctgttttgg ggaagctttt ttggaagcat    360
 tttcatgctg agtccctttt tacctttgat gtttgtaaac ccatcttggt atcgctggat    420
 caacaaccgc cttgtggcaa catggctcac cctacctgtg gcattattgg agaccatgtt    480
 tggtgtaaaa gtgattataa ctggggatgc atttgttcct ggagaaagaa gtgtcattat    540
 catgaaccat cggacaagaa tggactggat gttcctgtgg aattgcctga tgcgatata     599



      <210> 578
      <211> 1284
      <212> DNA
      <213> Homo sapiens


      <400> 578
 atgaacatga acatcaaaaa aattgtaaaa caagccacag ttctgacttt tacgactgca     60
 cttctggcag gaggagcgac tcaagccttc gcgaaagaaa ataaccaaaa agcatacaaa    120
 gaaacgtacg gcgtctctca tattacacgc catgatatgc tgcagatccc taaacagcag    180
 caaaacgaaa aataccaagt gcctcaattc gatcaatcaa cgattaaaaa tattgagtct    240
 gcaaaaggac ttgatgtgtg ggacagctgg ccgctgcaaa acgctgacgg aacagtagct    300
 gaatacaacg gctatcacgt tgtgtttgct cttgcgggaa gcccgaaaga cgctgatgac    360
 acatcaatct acatgtttta tcaaaaggtc ggcgacaact caatcgacag ctggaaaaac    420
 gcgggccgtg tctttaaaga cagcgataag accccactca atcgacgctg gaaaaacgcg    480
 ggccgtgtct ttaaagacag cgataagttc gacgccaacg atccgatcct gaaagatcag    540
 acgcaagaat ggtccggttc tgcaaccttt acatctgacg gaaaaatccg tttattctac    600
 actgactatt ccggtaaaca ttacggcaaa caaagcctga caacagcgca ggtaaatgtg    660
 tcaaaatctg atgacacact caaaatcaac ggagtggaag atcacaaaac gatttttgac    720
 ggagacggaa aaacatatca gaacgttcag cagtttatcg atgaaggcaa ttatacatcc    780
 ggcgacaacc atacgctgag agaccctcac tacgttgaag acaaaggcca taaatacctt    840
 gtattcgaag ccaacacggg aacagaaaac ggataccaag gcgaagaatc tttatttaac    900
 aaagcgtact acggcggcgg cacgaacttc ttccgtaaag aaagccagaa gcttcagcag    960
 agcgctaaaa aacgcgatgc tgagttagcg aacggcgccc tcggtatcat agagttaaat   1020
 aatgattaca cattgaaaaa agtaatgaag ccgctgatca cttcaaacac gttgcatgcc   1080
 acagataaag ataagcgtgc acctgccact gcaataaccc atggtttccg agacccctgc   1140
 cacagccaga ctgtcccacg tcggccaccg tcgagccccc actttatcca atcagatcgc   1200
 ggggaaggac acgcaaacct gccgagggct cgagggctcc gggctgctgc tgctgccagc   1260
 gtcctgggaa gtgacaggca ttag                                          1284



      <210> 579
      <211> 606
      <212> DNA
      <213> Homo sapiens


      <400> 579
 tttcgtgcaa ctggttcggg aaggggaagc gggggttcat catgggcatc tggaattccc     60
 acacatctgt gggcgacatc ctgggctccc tgatcgccgg catctgggtg aacgggcagt    120
 ggggcctgtc gttcatcgtg cctggcatca ttactgccgt catgggcgtc atcaccttcc    180
 tcttcctcat cgaacaccca gaagatgtgg actgcgcccc tcctcagcac cacggtgagc    240
 cagctgagaa ccaggacaac cctgaggacc ctgggaacag tccctgctct atcaaggaga    300
 gcggccttga gactgtggcc aaatgctcca aggggccatg cgaagagcct gctgccatca    360
 gcttctttgg ggcgctccgg atcccaggcg tggacgagtt ctctctgtgt ctgctgatag    420
 ccaagctggt cagttacacc ttcctctact ggctgcccct ctacatcgcc aatgtggctc    480
 actttagtgc caaggaggct ggggacctgt ctacactctt ccatgttggt ggcatcatag    540
 gcggaatcga ggcagggctc gtctctgact acaccaatgg cagggccacc acttgctgtg    600
 tcatgg                                                               606



      <210> 580
      <211> 1025
      <212> DNA
      <213> Homo sapiens


      <400> 580
 caggccacta tccttgataa acatacatgc aaacttcctc agcaaaatac tagcaaactc     60
 aattaaacaa tgccttaata ggatcatcca ccatgatgga gtgagattta tctttgagat    120
 gtaagaataa tttaacatac atagatcaat aaatgtgaca tactacatta acagaatgaa    180
 gaataaaaat atgatcatca gatgcagaaa aagcatttga caatattcaa caccctttca    240
 taataaaaat tctcatcaaa ttaggtatag aaggaacata gctcaataca ataaaggccc    300
 tactgatggc agcagcggcc tgtctgaagc agctgctgca aagatgccag aagcagcagg    360
 ggaggcatgg cagaaggctg caggctctcg gcctcctctg aactttgggc accaatgagc    420
 atgggagggg gactgaggta ggcctgaggg cagcttggcg caggcctgca ggcccctttg    480
 gcacaaacag cctgggtgcc atggacatta ttgatggcaa caggaggcag acaggctcct    540
 gggtggaaag gggcacattc ctggtgaagc cccaccttca agccagtgac agcctgaagc    600
 atgggggctg ggctgtcagt ttcaggtgga gtccacagac cacagtgaga acttgtggta    660
 ctttttctgg gcccactcat ggccacggac ttatcagcat gcacttcctc cctcgtgagt    720
 ccattcacag ggccagagtt ccaagtgtgc ggcgtgggcg gggcctgcag aaagggacgg    780
 ggcctgcaga aagggacggg gctggcaaag gcctggtcta cctcaccgat ccgggtcgcg    840
 ggggctccta gggggttcct tccacagtgt ccaagacagc gattccgcgg ctcctctgag    900
 aactggcgct tgtgagtgac tgaacgggcc actggagagg agcggtgctc acgggtatcg    960
 ttctcgtcag cgggcggtgg ggacgcgggg tcttggaatt gggaatcacg cttgagggcg   1020
 tccat                                                               1025



      <210> 581
      <211> 954
      <212> DNA
      <213> Homo sapiens


      <400> 581
 cccagatcat cgacatggtg cgttgtggtg gtggtacagc tgtggagtct tacctgtcac     60
 agtgtcaaga aatgaagggg atgaacggaa ccaggtgctg accctgtatc tgtggatacg    120
 gcaggagtgg acagatgcct acctacgatg ggaccccaat gcctatggtg gcctggatgc    180
 catccgcatc cccagcagtc ttgtgtggcg gccagacatc gtactctata acaagtactg    240
 cctatctggg cccctcctct ctcttacccc tctctagact tgcccttagc tgtgggggtg    300
 tagtgatccc ctctccctac cacataacct ggttgccacg ctgccctgga agcttttccc    360
 caggaccctt ctaagctgcc aagcactcag cccctccatg gcacccccac tttaggctat    420
 cccaggccag cccaggctga acgtctcctc ggaacctact gtgtggtcca gggcagatgt    480
 ctgaatcaca agggcctctc tagggcacac ttttagctct aagtctctca gggctccccc    540
 aagagcctgt ctaagggtct ctttcctcca ggacatagcc ctctggaaca ctgctttatg    600
 tctccttgac cagttccgtg tctcccagcc agcacatagc tctgcatatt ttctctgggg    660
 cccttctaca agttttgcag atgtccccca agggaagtca ctgtgtgtcc cggagctacc    720
 tctgggttct gcagaggcct ttttatacat cctctggcta cgtctgtgtc ccttctggcg    780
 ccttcaggca ccaccccttc caggcctcga aaggcagcgg gtctctctag gtgcactcca    840
 ccctctgtgt tgctttgttc tgaaaacaag aatcaaatta acgaaaaaaa aacaagcaca    900
 agtttattta tttatttgag acacagcctg ggcaagagag tgagacttca tctc          954



      <210> 582
      <211> 641
      <212> DNA
      <213> Homo sapiens


      <400> 582
 attacgccaa gcttggcacg aggctactgc cctcactgga cttggggggt ctggaccttt     60
 ggcccctgcc ccctggggga cccagacctc tgggccctca cttctggccc ttacagagat    120
 ccaggcatcc aacaccccca tccctgccca agcgtctgag gtgttagtgg tggggggaga    180
 agcccaccat cccagactct ggtaaatgtc tttgctggtt ccttgcagct ggcagtgggg    240
 gggaccccag cccaggccca ggcctaggcc tggggtgggg atagggtcag atgaagaatt    300
 cctctttcct cttgtgtccg tcgctgccat tgaggaaggc ttctcttgct tctccctgtt    360
 catccaagcc actggcttcg tgggtcagat aggaaccctt ctgccgtacc gagcaccaga    420
 ccatgcccac tagcacacat atgatcagaa acaccagcag cgccaggatg ccgcccacaa    480
 tggcataggg aaccgacgtc tgagcctcta ccaccgcacc agggtcgtag accacaagta    540
 cgtagagcgc cctcgcatgg ccgtgcttat tggacgcctc gcaagtgtag gtgccgttat    600
 ccgcggatac cagacccggg agcgtgagcc gctctcccac g                        641



      <210> 583
      <211> 687
      <212> DNA
      <213> Homo sapiens


      <400> 583
 ccaggaacta cagctatagt agggggcgcc taggttggtg gctccagggc gccggatcgg     60
 ctcctttgag ggcccaccgc ggcccgagac tcctccccgg aagtttcctc ggatggcagc    120
 aggcacagcg aggtggccga gccgcccaga gaacgtccaa ggcccacctc cggctccgcg    180
 gatgccgtct cggcctccat ggccttggcc tcgacggcgc gggcgggggc agcctgggac    240
 tccacctcgc gcagcgccta gtagtggtcc tgggccggca gggccggggc ctgttccgcg    300
 cctgtgcctg cgccgttggt ctgcgagcac acgtgcctga cccgcgggag cgccctggag    360
 cccttgacgc ggcggctgtc cccgtcgcca tacaccttat agcggatcat gagcagaacg    420
 atgaagacga ggcccgaggc gacgatgacg cccccgatgg cgatgatcat ggtgccgccc    480
 aagaaatggg ccctcagcgg gcggcagggc gccggatccc cagcggtggt gaactgtaca    540
 cagcccacca ctcgcgttgc cggcagcgct gtggccccgt cgtcgtagac cgccagcacg    600
 cacaagtcgt aggcacggcc cgccgccagg tcattcacca gaaaggtctg actggtggac    660
 gggatcatcc tgtagacgag ggagtct                                        687



      <210> 584
      <211> 2304
      <212> DNA
      <213> Homo sapiens


      <400> 584
 gcggccgcag cctgaagcca gggccccctc cctcgtcagg accggggcag caagcaggcc     60
 gggggcaggt ccgggcaccc accatgcgag gcgagctctg gctcctggtg ctggtgctca    120
 gggaggctgc ccgggcgctg agcccccagc ccggagcagg tcacgatgag ggcccaggct    180
 ctggatgggc tgccaaaggg accgtgcggg gctggaaccg gagagcccga gagagccctg    240
 ggcatgtgtc agagccggac aggacccagc tgagccagga cctgggtggg ggcaccctgg    300
 ccatggacac gctgccagat aacaggacca gggtggtgga ggacaaccac agctattatg    360
 tgtcccgtct ctatggcccc agcgagcccc acagccggga actgtgggta gatgtggccg    420
 aggccaaccg gagccaagtg aagatccaca caatactctc caacacccac cggcaggctt    480
 cgagagtggt cttgtccttt gatttccctt tctacgggca tcctctgcgg cagatcacca    540
 tagcaactgg aggcttcatc ttcatggggg acgtgatcca tcggatgctc acagctactc    600
 agtatgtggc gcccctgatg gccaacttca accctggcta ctccgacaac tccacagttg    660
 tttactttga caatgggaca gtctttgtgg ttcagtggga ccacgtttat ctccaaggct    720
 gggaagacaa gggcagtttc accttccagg cagctctgca ccatgacggc cgcattgtct    780
 ttgcctataa agagatccct atgtctgtcc cggaaatcag ctcctcccag catcctgtca    840
 aaaccggcct atcggatgcc ttcatgattc tcaatccatc cccggatgtg ccagaatctc    900
 ggcgaaggag catctttgaa tatcaccgca tagagctgga ccccagcaag gtcaccagca    960
 tgtcggccgt ggagttcacc ccattgccga cctgcctgca gcataggagc tgtgacgcct   1020
 gcatgtcctc agacctgacc ttcaactgca gctggtgcca tgtcctccag agatgctcca   1080
 gtggctttga ccgctatcgc caggagtgga tggactatgg ctgtgcacag gaggcagagg   1140
 gcaggatgtg cgaggacttc caggatgagg accacgactc agcctcccct gacacttcct   1200
 tcagccccta tgatggagac ctcaccacta cctcctcctc cctcttcatc gacagcctca   1260
 ccacagaaga tgacaccaag ttgaatccct atgcaggagg agacggcctt cagaacaacc   1320
 tgtcccccaa gacaaagggc actcctgtgc acctgggcac catcgtgggc atcgtgctgg   1380
 cagtcctcct cgtggcggcc atcatcctgg ctggaattta catcaatggc caccccacat   1440
 ccaatgctgc gctcttcttc atcgagcgta gacctcacca ctggccagcc atgaagtttc   1500
 gcagccaccc tgaccattcc acctatgcgg aggtggagcc ctcgggccat gagaaggagg   1560
 gcttcatgga ggctgagcag tgctgagaac accaagtctc ccctttgaag actttgaggc   1620
 cacagaaaag acagttaaag caaagaagag aagtgacttt tcctggcctc tcccagcatg   1680
 ccctgggctg agatgagatg gtggtttatg gctccagagc tgctgctcgc ttcgtcagca   1740
 caccccgaat attgaagagg gggccaaaaa acaaccacat ggatttttta taggaacaac   1800
 aacctaatct catcctgttt tgatgcaagg gttctcttct gtgtcttgta accatgaaac   1860
 agcagaagaa ctaacataac taactccatt tttatttaag gggcctttac ctattcctgc   1920
 acctaggcta ggataacttt agagcactga gataaaacgc aaaaacagga atcatgccgt   1980
 ttgcaaaact aactctggga ttaaagggga agcatgtaaa cagctaactg tttttgttaa   2040
 aggtttatag gaatgaggag gtttggctat tgtcacatga cagactgtta gccaaggaca   2100
 aagaagttct gcaaacctcc cctggaccct tgctggtgtc cagatgtctg cggttgtcag   2160
 ccccttcctt tcccccgacc taaacataaa agacaaggca aagcccgcat aattttaaga   2220
 cggttcttta ggacattagt ccaccatctt cttggtttgc tggctctccg aaataaagtc   2280
 cctttccttg ctccaaaaaa aaaa                                          2304



      <210> 585
      <211> 2304
      <212> DNA
      <213> Homo sapiens


      <400> 585
 gcggccgcag cctgaagcca gggccccctc cctcgtcagg accggggcag caagcaggcc     60
 gggggcaggt ccgggcaccc accatgcgag gcgagctctg gctcctggtg ctggtgctca    120
 gggaggctgc ccgggcgctg agcccccagc ccggagcagg tcacgatgag ggcccaggct    180
 ctggatgggc tgccaaaggg accgtgcggg gctggaaccg gagagcccga gagagccctg    240
 ggcatgtgtc agagccggac aggacccagc tgagccagga cctgggtggg ggcaccctgg    300
 ccatggacac gctgccagat aacaggacca gggtggtgga ggacaaccac agctattatg    360
 tgtcccgtct ctatggcccc agcgagcccc acagccggga actgtgggta gatgtggccg    420
 aggccaaccg gagccaagtg aagatccaca caatactctc caacacccac cggcaggctt    480
 cgagagtggt cttgtccttt gatttccctt tctacgggca tcctctgcgg cagatcacca    540
 tagcaactgg aggcttcatc ttcatggggg acgtgatcca tcggatgctc acagctactc    600
 agtatgtggc gcccctgatg gccaacttca accctggcta ctccgacaac tccacagttg    660
 tttactttga caatgggaca gtctttgtgg ttcagtggga ccacgtttat ctccaaggct    720
 gggaagacaa gggcagtttc accttccagg cagctctgca ccatgacggc cgcattgtct    780
 ttgcctataa agagatccct atgtctgtcc cggaaatcag ctcctcccag catcctgtca    840
 aaaccggcct atcggatgcc ttcatgattc tcaatccatc cccggatgtg ccagaatctc    900
 ggcgaaggag catctttgaa tatcaccgca tagagctgga ccccagcaag gtcaccagca    960
 tgtcggccgt ggagttcacc ccattgccga cctgcctgca gcataggagc tgtgacgcct   1020
 gcatgtcctc agacctgacc ttcaactgca gctggtgcca tgtcctccag agatgctcca   1080
 gtggctttga ccgctatcgc caggagtgga tggactatgg ctgtgcacag gaggcagagg   1140
 gcaggatgtg cgaggacttc caggatgagg accacgactc agcctcccct gacacttcct   1200
 tcagccccta tgatggagac ctcaccacta cctcctcctc cctcttcatc gacagcctca   1260
 ccacagaaga tgacaccaag ttgaatccct atgcaggagg agacggcctt cagaacaacc   1320
 tgtcccccaa gacaaagggc actcctgtgc acctgggcac catcgtgggc atcgtgctgg   1380
 cagtcctcct cgtggcggcc atcatcctgg ctggaattta catcaatggc caccccacat   1440
 ccaatgctgc gctcttcttc atcgagcgta gacctcacca ctggccagcc atgaagtttc   1500
 gcagccaccc tgaccattcc acctatgcgg aggtggagcc ctcgggccat gagaaggagg   1560
 gcttcatgga ggctgagcag tgctgagaac accaagtctc ccctttgaag actttgaggc   1620
 cacagaaaag acagttaaag caaagaagag aagtgacttt tcctggcctc tcccagcatg   1680
 ccctgggctg agatgagatg gtggtttatg gctccagagc tgctgctcgc ttcgtcagca   1740
 caccccgaat attgaagagg gggccaaaaa acaaccacat ggatttttta taggaacaac   1800
 aacctaatct catcctgttt tgatgcaagg gttctcttct gtgtcttgta accatgaaac   1860
 agcagaagaa ctaacataac taactccatt tttatttaag gggcctttac ctattcctgc   1920
 acctaggcta ggataacttt agagcactga gataaaacgc aaaaacagga atcatgccgt   1980
 ttgcaaaact aactctggga ttaaagggga agcatgtaaa cagctaactg tttttgttaa   2040
 aggtttatag gaatgaggag gtttggctat tgtcacatga cagactgtta gccaaggaca   2100
 aagaagttct gcaaacctcc cctggaccct tgctggtgtc cagatgtctg cggttgtcag   2160
 ccccttcctt tcccccgacc taaacataaa agacaaggca aagcccgcat aattttaaga   2220
 cggttcttta ggacattagt ccaccatctt cttggtttgc tggctctccg aaataaagtc   2280
 cctttccttg ctccaaaaaa aaaa                                          2304



      <210> 586
      <211> 404
      <212> DNA
      <213> Homo sapiens


      <400> 586
 aaacttgtac cactgtggta gtaatccctc gcatgttggt ggactttcta tcagagagca     60
 agaccatttc tcttcctgag tgtgccacac agatgttttt ctttctgggc tttgcatcca    120
 acaactgttt catcatggcc gctatgtcct acgaccgcta cacggccatc cacaacccac    180
 tgcagtacca cacccttatg acaagaaaga tctgcttgca gatgatgatg gcttcttgga    240
 tggttgggtt cctgttttct ctgtgcatca tcgtcactgt attcaacttg tctctttgcg    300
 acttgaacac tatccagcac tatttctgtg atatctcacc agtggtctcc cttgcttgta    360
 attacacttt ctatcatgaa atggctattt ttgtgctctc tgcc                     404



      <210> 587
      <211> 1774
      <212> DNA
      <213> Homo sapiens


      <400> 587
 gggagactac ctgcaggcca gaattcactc cctcaagctg caggctgggg ctgtgggcag     60
 ggtggtggat taccagaatg ggttttacaa ggttttcttt actttgctat ggccaggcaa    120
 agttaaagta tccgtatctc tggtccaccc cagtgaaggg atcagagttc ttcagcgctt    180
 acaggaagat aaaccagaca gggtctattt caagagtctc ttccgttcag gaagaatttc    240
 tgaaactact gagtgcaacg tgtgtcttcc tgggaatctg cccctgtgta actttacaga    300
 cctctacact ggggagccct ggttctgctt caaaccaaag aagctccctt gcagcagcag    360
 aattacccat ttcaaaggtg gatacctgaa aggtctccta accgctgcag agagtgcttt    420
 cttccagagt ggtgtcaata tcaaaatgcc agtcaactcc agtggacctg attgggtaac    480
 tgtgattccc aggagaataa aagaaactaa cagtctagaa ctatctcaag gctcaggaac    540
 ttttccttct gggtattatt ataaagacca gtggaggccc agaaagttta agatgcgtca    600
 gtttaatgac cctgacaaca ttacagagtg cttacaaaga aaagtggtgc atttatttgg    660
 tgactcaaca atcaggcaat ggtttgaata ccttactaca tttgttccag atttagtgga    720
 gtttaacttg ggtagtccca agaatgtggg tcccttcctt gcagtggacc agaagcacaa    780
 catcctgctc aaataccgct gccatggtcc acccatccgc ttcacgactg tctttagcaa    840
 tgagctccat tatgtggcga atgagctgaa tggcattgtg ggagggaaga acacagtggt    900
 tgccatagct gtatggtctc acttcagcac cttccctttg gaagtgtaca tccggcggct    960
 caggaacatc cgtcgagcag tggttcggct cctcgatcga agcccaaaga ccgtggtggt   1020
 catccggacg gccaacgccc aagagctggg acctgaggtg agccttttca acagcgactg   1080
 gtacaacttt cagctggaca ccatccttcg gaggatgttc tcaggggttg gagtatatct   1140
 cgtcgatgcc tgggagatga ccctggccca ttatctaccg cacaagctgc atccagatga   1200
 agttattgtg aagaaccagc tggacatgtt cttgtccttt gtgtgcccct tggaaaccta   1260
 gcctgtcttg gaagggactg gaggaatcat attcaatgac cttctcaatt gacctgagtt   1320
 acagaaagtg gccccagtga gagatgactg cccttaataa gtataaaatt tcaaaaagat   1380
 ctggacttaa tatgatgact tataaggagc ttaaaaaatg caggttacat ttatatctac   1440
 ctataggatt ttatccaatg ttgacttagc catggtagaa ctcttaactg catctacaca   1500
 ctatattgct cttgtaacca aagatgctaa tgagtgtatt tgaattagct tctcctagga   1560
 ggggtgacta ctttgctaaa gagtatgaaa aatgttttga tggaagggac aagtttggtt   1620
 ggtagtagag tgtttgtagc ttatctggta aaggaaattg agtgcatctg catgcatagc   1680
 acaagtaatc catcttctgg cggttaacta gagaaagctt atagtcagag gctcttgtga   1740
 atgcactgaa gactgctgtg tctcaggagt ttct                               1774



      <210> 588
      <211> 1663
      <212> DNA
      <213> Homo sapiens


      <400> 588
 gcctcgaatt cccgggtcga cgatttcgtc tcccttggtc ctggtgctgg tggtggctgt     60
 gacagtgcgg gcggccttgt tccgctccag tctggccgag ttcatttccg agcgggtgga    120
 ggtggtgtcc ccactgagct cttggaagag agtggttgaa ggcctttcac tgttggactt    180
 gggagtatct ccgtattctg gagcagtatt tcatgaaact ccattaataa tatacctctt    240
 tcatttccta attgactatg ctgaattggt gtttatgata actgatgcac tcactgctat    300
 tgccctgtat tttgcaatcc aggacttcaa taaagttgtg tttaaaaagc agaaactcct    360
 cctagaactg gaccagtatg ccccagatgt ggccgaactc atccggaccc ctatggaaat    420
 gcgttacatc cctttgaaag tggccctgtt ctatctctta aatccttaca cgattttgtc    480
 ttgtgttgcc aagtctacct gtgccatcaa caacaccctc attgctttct tcattttgac    540
 tacgataaaa ggcagtgctt tcctcagtgc tatttttctt gccttagcga cataccagtc    600
 tctgtaccca ctcaccttgt ttgtcccagg actcctctat ctcctccagc ggcagtacat    660
 acctgtgaaa atgaagagca aagccttctg gatcttttct tgggagtatg ccatgatgta    720
 tgtgggaagc ctagtggtaa tcatttgcct ctccttcttc cttctcagct cttgggattt    780
 catccccgca gtctatggct ttatactttc tgttccagat ctcactccaa acattggtct    840
 tttctggtac ttctttgcag agatgtttga gcacttcagc ctcttctttg tatgtgtgtt    900
 tcagatcaac gtcttcttct acaccatccc cttagccata aagctaaagg agcaccccat    960
 cttcttcatg tttatccaga tcgctgtcat cgccatcttt aagtcctacc cgacagtggg   1020
 ggacgtggcg ctctacatgg ccttcttccc cgtgtggaac catctctaca gattcctgag   1080
 aaacatcttt gtcctcacct gcatcatcat cgtctgttcc ctgctcttcc ctgtcctgtg   1140
 gcacctctgg atttatgcag gaagtgccaa ctctaatttc ttttatgcca tcacactgac   1200
 cttcaacgtt gggcagatcc tgctcatctc tgattacttc tatgccttcc tgcggcggga   1260
 gtactacctc acacatggcc tctacttgac cgccaaggat ggcacagagg ccatgctcgt   1320
 gctcaagtag gcctggctgg cacagggctg catggacctc agggggctgt ggggccagaa   1380
 gctgggccaa gccctccagc cagagttgcc agcaggcgag tgcttgggca gaagaggttc   1440
 gagtccaggg tcacaagtct ctggtaccaa aagggaccca tggctgactg acagcaaggc   1500
 ctatggggaa gaactgggag ctccccaact tggaccccca ccttgtggct ctgcacacca   1560
 aggagccccc tcccagacag gaaggagaag aggcaggtga gcagggcttg ttagattgtg   1620
 gctacttaat aaatgttttt tgttatgaag tctaaaaaaa aaa                     1663



      <210> 589
      <211> 892
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(892)
      <223> n = a,t,c or g


      <400> 589
 ggaggagggg gntnnntttc gagattccta gtccgtgtgg aggaattccc atctttccct     60
 tctgggtgcg actgacaaac gaggagtccc acgaagtctt tttcagtggc ctatttgaga    120
 actgcttcaa tgccaaatgc tggaagcctc gacccttatc catttacatc atcctcggcc    180
 gggttttcct gctctctgca gttttcttgg ctttcgtcac caccttcatc atgatgccct    240
 ttgcatccga gttcttcccg aggacctgga agcaaaactt tgtgttagcc tgcatcagct    300
 tcttcacagg ggcctgtgcc ttcctggctt tggtgctgca tgccctggag atcaaggctc    360
 tgaggatgaa gctcggcccc ctgcagttct ccgtgctgtg gccttactac gtgctgggct    420
 tcggcatctt tctgttcata gtggctggta ccatctgcct cattcaagaa atggtttgcc    480
 cttgctggca cttgttgtcc acttcccaga gtatggagga ggaccacggg agcctgtacc    540
 tggacaatct ggagagtttg ggaggagaac cgagctcagt acaaaaggag acacaggtga    600
 cagcagaaac agtcatctag cccaggacat ggcttcttta cccttcttca agccatgtga    660
 gtgtacacat gtagctgttt gtagtcctcc ccaccctctc tgccagtatc tgtgcctttg    720
 aggagcttct tgcgtgtcag atcaactctc cacctcccca tactcacagt gattctatct    780
 tgcttgtatg tgaaatttgc taaaagtcct ttcaactctt ctgagcttcc taagtgacgt    840
 ttttgcaggt attttcaata aaaagaaggg ctactttgtt aaaaaaaaaa aa            892



      <210> 590
      <211> 397
      <212> DNA
      <213> Homo sapiens


      <400> 590
 tattggaaga gtgaagagca gagaacttta agtttgaaat ttggcatcac tgccctgaac     60
 aatataacct tagttggcat aaactactca tacagacaaa ggcattatcc atcacaataa    120
 gtaacttttt gtctttattt caaccggaca atcgtgatta gaaaagctcc tgtgacaaaa    180
 ttcaagaaaa cctgacataa atgaacaaca atacaacatg tattcaacca tctatgatct    240
 cttccatggc tttaccaatc atttacatcc tcctttgtat tgttggtgtt tttggaaaca    300
 ctctctctca atggatattt ttaacaaaaa taggtaaaaa aacatcaacg cacatctacc    360
 tgtcacacct tgtgactgca aacttacttg tgtgcgc                             397



      <210> 591
      <211> 461
      <212> DNA
      <213> Homo sapiens


      <400> 591
 cacatgattt tcagggcagt tgtttggcag actgctacat taaggcttaa accagttgaa     60
 gaactttatt cttcaaagat acttgcattt caacaaggaa ggaagctttt aaggaagaga    120
 aaaacaaccc tcattgtggt tttagtaagc attaagggga ggacatgaat tcagcttata    180
 tgtgcctgga atcccatcac aaagctacat agtaacaaag cttctgagaa aggcagtatc    240
 ttatcaatgt catatttttt ctttctttct gtgttttaca tttgattttt tttaacgttt    300
 tgttttttag ccgtgctatc aagactaatc aggaccttct cccagaaact ccatggacgc    360
 acattttcta caatgatttt tgggggactc ttctaaccca cagtggcagc cacaagtcct    420
 accggccact ctgcactctt tcttttcgcc tgaaccatgc c                        461



      <210> 592
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 592
 ctgcagcaac cgcgtcttca ctgagggcac ctgtaagctg ctgaccttgg tggtcactga     60
 cctggtagac caggacctgg tgctgaacca ccgcaagcag gcagcctcgg cactcctctt    120
 tggcatggtt gccttggtga ccaagccagg ccagaccttt gccccgctgc tgggcacctg    180
 gctgctctgt ttctacacag gtcatgacct cttccagcag tccctcataa cccctgtggg    240
 gagtgcccat ccctggccag agcccccagc tccagcccct gcacaggccc cgacgctccg    300
 ccagggctgc ttctacctgc tggtgctggt gcccatcacc tgtgctctgc tgcagctctt    360
 cacctgcgcc cagttcacgc tgcatgggag acgcctgcac atggtcaagg cc            412



      <210> 593
      <211> 1377
      <212> DNA
      <213> Homo sapiens


      <400> 593
 aatgcaaagt atggcgaaat ccactaaatt tatttagggg tgctgaatac aatcggtata     60
 cttgggtgac aggacgagag cctcttactt actatgacat gaatctctct gcccaagacc    120
 accagacatt ctttacttgt gactcggacc atctgcgtcc cgcagatgca ataatgcaga    180
 aagcctggag agagagaaac ccccaagcta ggatttctgc agctcatgaa gccttggaga    240
 taaatgagtg tgcaactgct tatattctct tggctgaaga ggaagcaaca accattgctg    300
 aagcagaaaa attatttaag caggccctga aggctggaga tggctgttac cgacgctctc    360
 agcagctaca acatcatgga tcccagtatg aagcccaaca tagtgtttta tatctccctc    420
 ttcaggacga gacaccaatg tcttggtgta catcaaaaga aggctagcaa tgtgtgccag    480
 aagactcggg aggaccaggg aagcagtgaa aatgatgaga gatttaatga aggagttccc    540
 ccttctgagt atgttcaata tccatgaaaa ccttttagaa gcccttctgg aactacaagc    600
 atatgctgat gttcaggcag tcttagcaaa gtatgatgat ataagcttac caaagtcagc    660
 aacaatatgc tacacagctg ctttgctcaa agcaagagct gtctctgaca aattctctcc    720
 tgaggctgca tctcggcggg ggctgagcac agcagagatg aatgcagtag aggccattca    780
 tagagctgtg gaattcaatc ctcatgtgcc aaaataccta ctagaaatga aaagcttaat    840
 cctaccccca gaacatatcc tgaagagagg agacagtgaa gcaatagcat atgcattctt    900
 tcatcttgca cactggaaga gagtggaagg ggctttgaat cttttgcatt gtacgtggga    960
 aggcactttt cggatgatcc cttatccctt ggaaaagggg cacctatttt atccttaccc   1020
 aatctgtaca gaaacagcag accgagagct gcttccatct ttccatgaag tctcagttta   1080
 cccaaagaag gagcttccct tctttattct ctttactgct ggattatgtt ccttcacagc   1140
 catgctggcc ctcctgacac atcagttccc ggaacttatg ggggtcttcg caaaagctgt   1200
 gagtgtttgc ctagagggag gccttgggga atggatgggg aaagccaagg gcataaaagc   1260
 agcgtgagag aaatggggtt gccttacaga aatgggtacg agcctgcaaa gatcattgct   1320
 caccatttaa ttttcatgat catcaatgga atcaaagcat taagggtcac atgagaa      1377



      <210> 594
      <211> 1377
      <212> DNA
      <213> Homo sapiens


      <400> 594
 aatgcaaagt atggcgaaat ccactaaatt tatttagggg tgctgaatac aatcggtata     60
 cttgggtgac aggacgagag cctcttactt actatgacat gaatctctct gcccaagacc    120
 accagacatt ctttacttgt gactcggacc atctgcgtcc cgcagatgca ataatgcaga    180
 aagcctggag agagagaaac ccccaagcta ggatttctgc agctcatgaa gccttggaga    240
 taaatgagtg tgcaactgct tatattctct tggctgaaga ggaagcaaca accattgctg    300
 aagcagaaaa attatttaag caggccctga aggctggaga tggctgttac cgacgctctc    360
 agcagctaca acatcatgga tcccagtatg aagcccaaca tagtgtttta tatctccctc    420
 ttcaggacga gacaccaatg tcttggtgta catcaaaaga aggctagcaa tgtgtgccag    480
 aagactcggg aggaccaggg aagcagtgaa aatgatgaga gatttaatga aggagttccc    540
 ccttctgagt atgttcaata tccatgaaaa ccttttagaa gcccttctgg aactacaagc    600
 atatgctgat gttcaggcag tcttagcaaa gtatgatgat ataagcttac caaagtcagc    660
 aacaatatgc tacacagctg ctttgctcaa agcaagagct gtctctgaca aattctctcc    720
 tgaggctgca tctcggcggg ggctgagcac agcagagatg aatgcagtag aggccattca    780
 tagagctgtg gaattcaatc ctcatgtgcc aaaataccta ctagaaatga aaagcttaat    840
 cctaccccca gaacatatcc tgaagagagg agacagtgaa gcaatagcat atgcattctt    900
 tcatcttgca cactggaaga gagtggaagg ggctttgaat cttttgcatt gtacgtggga    960
 aggcactttt cggatgatcc cttatccctt ggaaaagggg cacctatttt atccttaccc   1020
 aatctgtaca gaaacagcag accgagagct gcttccatct ttccatgaag tctcagttta   1080
 cccaaagaag gagcttccct tctttattct ctttactgct ggattatgtt ccttcacagc   1140
 catgctggcc ctcctgacac atcagttccc ggaacttatg ggggtcttcg caaaagctgt   1200
 gagtgtttgc ctagagggag gccttgggga atggatgggg aaagccaagg gcataaaagc   1260
 agcgtgagag aaatggggtt gccttacaga aatgggtacg agcctgcaaa gatcattgct   1320
 caccatttaa ttttcatgat catcaatgga atcaaagcat taagggtcac atgagaa      1377



      <210> 595
      <211> 1377
      <212> DNA
      <213> Homo sapiens


      <400> 595
 aatgcaaagt atggcgaaat ccactaaatt tatttagggg tgctgaatac aatcggtata     60
 cttgggtgac aggacgagag cctcttactt actatgacat gaatctctct gcccaagacc    120
 accagacatt ctttacttgt gactcggacc atctgcgtcc cgcagatgca ataatgcaga    180
 aagcctggag agagagaaac ccccaagcta ggatttctgc agctcatgaa gccttggaga    240
 taaatgagtg tgcaactgct tatattctct tggctgaaga ggaagcaaca accattgctg    300
 aagcagaaaa attatttaag caggccctga aggctggaga tggctgttac cgacgctctc    360
 agcagctaca acatcatgga tcccagtatg aagcccaaca tagtgtttta tatctccctc    420
 ttcaggacga gacaccaatg tcttggtgta catcaaaaga aggctagcaa tgtgtgccag    480
 aagactcggg aggaccaggg aagcagtgaa aatgatgaga gatttaatga aggagttccc    540
 ccttctgagt atgttcaata tccatgaaaa ccttttagaa gcccttctgg aactacaagc    600
 atatgctgat gttcaggcag tcttagcaaa gtatgatgat ataagcttac caaagtcagc    660
 aacaatatgc tacacagctg ctttgctcaa agcaagagct gtctctgaca aattctctcc    720
 tgaggctgca tctcggcggg ggctgagcac agcagagatg aatgcagtag aggccattca    780
 tagagctgtg gaattcaatc ctcatgtgcc aaaataccta ctagaaatga aaagcttaat    840
 cctaccccca gaacatatcc tgaagagagg agacagtgaa gcaatagcat atgcattctt    900
 tcatcttgca cactggaaga gagtggaagg ggctttgaat cttttgcatt gtacgtggga    960
 aggcactttt cggatgatcc cttatccctt ggaaaagggg cacctatttt atccttaccc   1020
 aatctgtaca gaaacagcag accgagagct gcttccatct ttccatgaag tctcagttta   1080
 cccaaagaag gagcttccct tctttattct ctttactgct ggattatgtt ccttcacagc   1140
 catgctggcc ctcctgacac atcagttccc ggaacttatg ggggtcttcg caaaagctgt   1200
 gagtgtttgc ctagagggag gccttgggga atggatgggg aaagccaagg gcataaaagc   1260
 agcgtgagag aaatggggtt gccttacaga aatgggtacg agcctgcaaa gatcattgct   1320
 caccatttaa ttttcatgat catcaatgga atcaaagcat taagggtcac atgagaa      1377



      <210> 596
      <211> 1771
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1771)
      <223> n = a,t,c or g


      <400> 596
 tcagtcaaat ttccaggaac aaaagtcctt ttcatccttt tcttgcccct gctgctgtct     60
 ctgtcgcctc ccttgtgcaa actgagagaa catcagctgc cggtccagca gctccattct    120
 ctgctgtctc tggatgtcca gcgtggctcc catcccaatt ctggcttcgc tggtgggttc    180
 tctggaagtc aggtttcctg ttacggaaag caggctctgg atgttacatt tggggaatgt    240
 tagtgtcttc acacacggag ctgagagtgt ctgggtcccc agggggcgtt tcttgctttc    300
 ccttgctcgc tgccccagtg cggggagaat ggtggctgct tttgaatttc ctgactctgg    360
 tggcttcact gtcacatcta tggggtgtaa agggaggaag agtgtcgagt tttgtgccat    420
 gaacagattc cgtttctgca gaggacagcg tgcaggggac acccttcgag gctttggagc    480
 cacctaggaa gcaggctggc tgctgcacag gcctctgctg gcctccttgc acatgtcctt    540
 ggtgggtgag gcagccacgt gagatggctt ccggcacttt gctggcgtga gtaagccctt    600
 ccctggcaat gccagctctt gccgtcctca cctcctgngg ccccagtggc ccgcatgacg    660
 gctctctgtt ctacacagcc ctcctggtct tcagtgccct gggaaacatc cttgcccttt    720
 gccttacctg tcagagagag gaggaagatc aactgcacag gcatctacct ggtgcacctg    780
 gctgtgtctg acctgctgtt caccgtggcc ttaccgggaa gggtggtgtg ttatgtgctg    840
 ggctccagct ggcctttcgg caaggggctc tgcaggctga cggcgtttgt gctctacacc    900
 gacacctacg ggggggtcta cctcatggcc tgtgtgagcg tggaccatta cccaacttgt    960
 ggtctgtgcc cactggggcc cgtgcctccg cacggctggc cgcgccaggc tggtctgcgt   1020
 ggccatctgg accttggtgc tgctgcagac gatgcccttg ctcttgatgc ccatgaccaa   1080
 gccgctggtg ggcaagctgg cctgcatgga gtacagcagc atggagtcag tcctcgggct   1140
 gcccctcatg gtcctggtgg cctttgccat tggcttctgt gggccagtgg ggatcatcct   1200
 gtcctgctat atgaagatca cctggaagct gtgcagcaca gctgggagaa cccagtgacc   1260
 agcgggaaag gacaccaccg gcggggcaag cccgggagga cccagtgacc aaccagaaaa   1320
 gacgccaccc gcgggggcag cccaggagga cccagtgacc ccgcgggaaa ggacaccacc   1380
 agcaggacag cccgagagga cccagtgacc agcgggaaag gatgccaccg gcgggacagc   1440
 ccgggaggac ccagtgacca gcaggaaagg acgccactgg cgaggctgcc tgcttacgct   1500
 gctgatgctg gtggccgtgg tggtctgctt cagcccctac cacctcaaca tcaagcagtt   1560
 catggcgaga gggatgctcc acctgccatc ctgtgccgag cggagggctt tcttactgtc   1620
 ccttcaggcc accgtggccc tcatgaacat gaactgtggc attaccccat catttacttc   1680
 tttgcatcca cccattacag gaaatggctc ctgggcattt taaagctcaa agggtcttcc   1740
 tcctcctcct cctcctcctc caccttgtat t                                  1771



      <210> 597
      <211> 518
      <212> DNA
      <213> Homo sapiens


      <400> 597
 ctgtcagaat tgcttgatat gtttcagcct tatattcttt attgtgtgct ccctgacggt     60
 aaccacatct cccacagtat ctgacagttc tgtggcctga gaggcagagt ccatggcttc    120
 cagaacatgt gtcccaattg gttcctctcc tttcccacct ggactggctg cttttgacct    180
 ctaactcttt gtcttccaga aaacaataag cctcctcagg cagatgcagt cccagataaa    240
 gagctgaccc ttcctgtgga tagcacaacc ctggatggca gcaagagctc agatgatcag    300
 aaaattatct catatctctg ggaaaaaaca cagtgagtat tgacacaaaa tccttatttt    360
 tgcaaagcct ccagaccttt ggaagagcaa ggttttattt gctattatga gttgagttgc    420
 tcttaatggc ttatccagtg gggtgactga ggaagaaatg tttgcaattc caaacttcaa    480
 ctccaagaaa atgatattat aatcataatt tttgtaag                            518



      <210> 598
      <211> 698
      <212> DNA
      <213> Homo sapiens


      <400> 598
 agataacaca tgccacctct ggcctcaaaa ccactcatgg attatcacaa ggcccagggg     60
 gttacctttg agtttgtgtc ttctcttcct ctgaaattta tatgcacact tattacaaac    120
 ccacatgagg ctgattaata ctgcggccac agcagcgaga aaagcaagga tgacagcgac    180
 aaagtgcagg tcttcataga ggatctcaga gacgtgcagc acgatggtgc caaactggct    240
 gctccccagg cgctccgtca cggtgatgac atagtagccg gaatccctca ctcccacgct    300
 gaagagctgg atggagccgt tgtcaaaggt gcagactctg tccttgtggc tttgagagat    360
 gttggcctga gtccctggtt tccactccac gatcttctgc gttccccaat tggatgaata    420
 tgtccattcg atggtgggca ctccatgaca ggagtactca actgagagca ggatgtcttc    480
 tttgacagtg gcattgatgg tggcctgagg aatgtatagg gacacaccct gactctgcag    540
 acagcgggct gcggccaggc agagggcgaa gagtcctagg gagatgcctc gggtcttcct    600
 cctcccgctg ggcagaggcc tcatgggcga gcccggggcc tcgcgggccg gggtgtgtgc    660
 tggccgcacc gcgctgcagc tcctatgcag ccacgaaa                            698



      <210> 599
      <211> 970
      <212> DNA
      <213> Homo sapiens


      <400> 599
 tttttttttt ttcccatagt tgcttttatt tttccctaaa aaaaagagtc cattttctta     60
 tacagacatt catttatgta agacccacat caggcttttt ctaaagtgcc aaaacccgtg    120
 caatccccat aacttcaggt gagaattata atgggcagaa gaatgtatca actaaaatac    180
 tcaaggccat ctcaaatcct gaagagtccc tggtttctgt gacaaggggg aattttgcta    240
 gcaaataagt aaaatccagg taaatatgct ctaaatcttc atcttcaggt tcttaattct    300
 ttaacatatt gtatcagatt ttgtattcaa atctaattat attttgtaaa aaatgtttta    360
 aaaattccta gataaaattt tcattcatta attttctatt ttattctcta tacccttctt    420
 tgtttagtct gtcttctttt ctttccacaa attcccaagg acaatcccta aaaaaactat    480
 tagtcccagt gttcggttgg agataaattt attccaacaa tcctcaggtc tgtggatgtc    540
 tagagtgtaa atctggtgag tcagatgggc tcctacagca cccagggcag cgtagtaggg    600
 agcagtctgt ccactgttca cacccactag gctcagtgcc cccagcattg caacactgaa    660
 gccgctgagc cacggcttgg tattttctcc gaaccgcaga gccgttgact taagaccaat    720
 caaaacatca tctcttttgt cctgatgggc ataaatagtg tcatatatta gtgtccacat    780
 aactccagaa aaataaagag gcaggcaaac agatggatca caggaaccct tgatagcaga    840
 ccatccaagt aacgctcccc aattaaatgt caagcccaag gctagttgag gccagtatga    900
 aattcttttc attagtgggt aggtgatgac aagaagtaag gatcctgctc ccagagctat    960
 actgtagttg                                                           970



      <210> 600
      <211> 1393
      <212> DNA
      <213> Homo sapiens


      <400> 600
 ctatttttga gaagctgaag caactccaag gacacagttc acagaaattt ggttctcagc     60
 cccaaaatac tgattgaatt ggagacaatt acaaggactc tctggccaaa aacccttgaa    120
 gaggccccgt gaaggaggca gtgaggagct tttgattgct gacctgtgtc gtaccacccc    180
 agaatgtgca ctgggggctg tgccagatgc ctggggggga ccctcattcc ccttgctttt    240
 tttggcttcc tggctaacat cctgttattt tttcctggag gaaaagtgat agatgacaac    300
 gaccaccttt cccaagagat ctggtttttc ggaggaatat taggaagcgg tgtcttgatg    360
 atcttccctg cgctggtgtt cttgggcctg aagaacaatg actgctgtgg gtgctgcggc    420
 aacgagggct gcgggaagcg atttgcgatg ttcacctcca cgatatttgc tgtggttgga    480
 ttcttgggag ctggatactc gtttatcatc tcagccattt caatcaacaa gggtcctaaa    540
 tgcctcatgg ccaatagtac atggggctac cccttccacg acggggatta tctcaatgat    600
 gaggccttat ggaacaagtg ccgagagcct ctcaatgtgg ttccctggaa tctgaccctc    660
 ttctccatcc tgctggtcgt aggaggaatc cagatggttc tctgcgccat ccaggtggtc    720
 aatggcctcc tggggaccct ctgtggggac tgccagtgtt gtggctgctg tgggggagat    780
 ggacccgttt aaacctccga gatgagctgc tcagactcta cagcatgacg actacaattt    840
 cttttcataa aacttcttct cttcttggaa ttattaattc ctatctgctt cctagctgat    900
 aaagcttaga aaaggcaggt tattcccttc ctttcccaac ccagctttgc ctcgagttac    960
 gaattttgtt attttcaaat aaaaaatagt ttggccactt aacaaatttg atttataaat   1020
 ctttcaaatt agttcctttt tagaatttac caacaggttc aaagcatact tttcatgatt   1080
 tttttattac aaatgtaaaa tgtataaagt cacatgtact gccatactac ttctttgtat   1140
 ataaagatgt ttatatcttt ggaagtttta cataaatcaa aggaagaaag cacatttaaa   1200
 atgagaaact aagaccaatt tctgttttta agaggaaaaa gaatgattga tgtatcctaa   1260
 gtattgttat ttgttgtctt tttttgctgc cttgcttgag ttgcttgtga ctgatctttt   1320
 gaggctgtca tcatggctag ggttctttta tgtatgttaa attaaaacct gaattcagag   1380
 gtaacgtaaa aaa                                                      1393



      <210> 601
      <211> 2722
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2722)
      <223> n = a,t,c or g


      <400> 601
 tttttttttt ttaatatctt agaattttcc tttactccaa aaaaccccat atatacatgt     60
 ttctccttta taagcttaga gattgctttg gtggtcaagt gcagggcggc tgggggaggt    120
 aagaccttca ggaaggccat atcccggaca agacccagaa gggaagcccc cagagccaag    180
 ggtaggaggg ccccacccgg gtctcagcca ctcacttctc cagggcggat ccgagacact    240
 cacaggcctc agggaggggc caggtgctgc tcctggtcat tgcttccccc acaaggtttg    300
 catgaggagc agagacagtc cagtctcctg aacacccaca gggcacagag cccagtgcag    360
 ggggcagaca ccaccgcagc tcctgggacc aagaggaagc tcccagaggg gggcccagga    420
 acgctggggt gggtggacag ggctgggtag gggttccttc tgggccaaac ccccagagca    480
 gcagagcacc ccagtccaag gaagctcttc tcagggaccc aaggctccag agccaggaaa    540
 aagggagggg cggggcggga gcctgcatcc ccagtgccca tcagctctgg gggaaacctc    600
 cgtctcccgt ccctatggtg accacagcag cagaggggga tcctccatgc cccaggcagg    660
 ctggcatcag ggccacacag gggccaggag caggggtctc ggagtccaca gctcccggcc    720
 ccagtggtgg gctcagggct cctgggcgcc atgggtctca ccacagcctc gccagggaac    780
 aggaccatag ggagtccttc tccccatctc tagccaccca caggcccagc agagcacaca    840
 gccccaccct cgcacaggca cctgtggtct ccaagtaacc aagcccaggc cccaggggcc    900
 actgcagaca gcagctggga tctgcagagg gatctcagca gcgagcaggc agctggcgag    960
 gagaggtgcg tgtgagggag gggtggccct ctcctcagta ggaggaagta agagggtatc   1020
 taggccaatt tattcagctg gaaatcaatc tgtccagggc tggaccaggc gcctccccct   1080
 cgatacagct cctggctgaa gaggtcatca gagcagcagc tgtccccagg ccagtgtcac   1140
 gtcactgcgt acagttcctc ccgatcgttc ttgcagatct gatagtggca ggggaatttc   1200
 tgcgagcagg cccagggctc ggcgggctgg tcaggtggcg gcagcagcaa ggctgcgctc   1260
 ccggccagca ggatgtgcca gatgctgtgg gtgtagtagt agttgtcgct agtcatcatg   1320
 gaggtgtaga tggcgatgcc cacagaggcc atagagacgc cgggcaggag gtagaaggcc   1380
 cagcgctgcc acgaggtggg gtagcactgg cgccggtgcc cgcagcggta agcccacatg   1440
 gaggccatga tcacgaaggc aaagaggcag ggccccagca tgttccacat gcccctgcgg   1500
 tccagctgca aggacatggc gatgaccagt gtacccagaa gaaacagcac gtatttcagg   1560
 actgtcttga gccgtgccat gcacaggatg gtgacccaga tggccgcccc ggagcccaag   1620
 aagtcgcagt actgcagcgt gtcgtagctg aggatgcaca gcaccgcctc cccgggctgg   1680
 tcgcaggcgt ggtagaacgt ggagaagaac atggtgtagg cgtagacgga ggcctccacc   1740
 aggaagaatc gccgcactga gacggcgatg ggggccagga acatgaggtt gctgagcgtg   1800
 agcagcagtg tggccgccct ctgctgggcc accgtctggg ctgtgctgtt gtccgtgcag   1860
 ctccacccac gccagcctgc cttgcagctg cagctggcat acaggtagct gtgtctgcgg   1920
 agcaggaggc actggccata gggtccacaa tcgttcaaac agggcaccag gtacaaggtg   1980
 gtctccacgt ggaccacagc ctgctcacag tcctcagcat tctcagggca catgagctgc   2040
 agggagaggt accagttgtc tgtctctggg taggggatga tgaggttggc cctgcgagac   2100
 caggcgctca gagacaaagg gtagccctgg aagaaggctg tggtgcagtt gagcgaagta   2160
 ttgaagccaa ggaagggcga ggcagcattc acgcaggcca ctacgacggt ctcgttccgc   2220
 atctctgtct tgttggcccg cagggagatg gtgagggaac ccccgctgtc catgccggtg   2280
 ttcaggcgca gccgcatcac ggagggcgtg tccgaacaca ccctcaccga gaccctgtcc   2340
 aggggctgga agtgcaccga caccacgtcc atgtcctccc gcgtgactgg gtagtttgtg   2400
 aggcagaagg ggctgcggtc caccctgcca ctcctgccca ggtcctggtg gtcggggctc   2460
 ggggacagca gaccagagga ggcattgaag ctctggtttt ggctgctctg cagaaggggc   2520
 tggatggtca cgctccgtgg cctgcaagct gtgagggcag ctacagcact gaaagccact   2580
 gtcccgaggg gccccaccag gctctcagct gtcacttgca gccacccgga cgcgtgggcg   2640
 cacgcgtggg tcttcccnna ttncgnngnt ttcgaaaggc ntcagtntnn gnnnntcgag   2700
 tggattcagg taaaaccccc ga                                            2722



      <210> 602
      <211> 394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(394)
      <223> n = a,t,c or g


      <400> 602
 taccgcctgg tgcgcttcga ggacctggcg cgggagccgc tggcagaaat ccgtgcgctc     60
 tacgccttca ctgggctcag tctcacgcca cagctcgagg cctggatcca taacatcacc    120
 cacggatctg gacctggtgc gcgccgcgaa gccttcaaga cttcgtccag gaatgcgctc    180
 aacgtctccc aggcctggcg ccatgcgctg ccctttgcca agatccgccg cgtgcaggaa    240
 ctgtgcgctg gtgcgctgca gctgctgggc taccggcctg tgtactctga ggacgagcag    300
 cgcaacctcg cccttgatct ggtgctgcca cgaggcctga acggcttcac ttgagcatna    360
 tccaccgcct cgcacccccg aaattagtgg aggg                                394



      <210> 603
      <211> 398
      <212> DNA
      <213> Homo sapiens


      <400> 603
 tttcgtcgcg ctgctgcgag accagccgcg gcgtctttgg cagtagtggg cgtccttgcg     60
 ggtccaggag ggcccctctc ccgcgaccgc cgaccacgat gagagcgtga agaccctctc    120
 gaaaggaagg gctctgctct acacactggt gtctcctgcg gaagggcagc tgggcacgcc    180
 ttccagaccg aggttacttg ccacagaagt gtttctgggc tgcagccctc aaccttggcc    240
 caaataaact ttctgtatta attttgcctt agtgtcgttc tttaagtcaa caaggatggc    300
 caaggcagtc actaatctca cactcacctg atagccacag gaacaacatt ttcccagcta    360
 taagcaaaag ttgaaaaatc agtaacccaa gatgactc                            398



      <210> 604
      <211> 398
      <212> DNA
      <213> Homo sapiens


      <400> 604
 tttcgtcgcg ctgctgcgag accagccgcg gcgtctttgg cagtagtggg cgtccttgcg     60
 ggtccaggag ggcccctctc ccgcgaccgc cgaccacgat gagagcgtga agaccctctc    120
 gaaaggaagg gctctgctct acacactggt gtctcctgcg gaagggcagc tgggcacgcc    180
 ttccagaccg aggttacttg ccacagaagt gtttctgggc tgcagccctc aaccttggcc    240
 caaataaact ttctgtatta attttgcctt agtgtcgttc tttaagtcaa caaggatggc    300
 caaggcagtc actaatctca cactcacctg atagccacag gaacaacatt ttcccagcta    360
 taagcaaaag ttgaaaaatc agtaacccaa gatgactc                            398



      <210> 605
      <211> 517
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(517)
      <223> n = a,t,c or g


      <400> 605
 tttcgtcggg gatgaagatg aagacatccg ggacaggggt gctaaacccg tcatggtcta     60
 catccacgga ggctcttaca tggaagggac aggcaacatg attgatggca gcatcctcgc    120
 cagttatggc aatgtcatcg tcatcaccct caactatcgg gttggagtgc taggtttcct    180
 gagtactgga gatcaggctg ccaagggcaa ctatgggctc cttgaccaga tccaggccct    240
 ccgctgggtg agcgagaata ttgccttctt cgggggagac ccccgccgga tcactgtctt    300
 tggctcgggc attggtgcat cctgcgtcag cctcctcacg ttgtcacatc actcagaggg    360
 acttttccag agagccatca tccaaagtgg ctctgctctg tccagctggg ctgtgaccta    420
 ccaaccagtg aagtacaaca gcctgctgac agacaaagtg ggctgtaatg tgctggcccc    480
 cgtacgaaat cgtagncccg ggggttcatc gaccata                             517



      <210> 606
      <211> 469
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(469)
      <223> n = a,t,c or g


      <400> 606
 cttacatctt caccattctc aacaccctcc agggcgtctt catcctattg tttggttgcc     60
 tcatggacag gaagatacaa gaagctttgc gcaaacgctt ctgccgcgcc caagccccca    120
 gctccaccat ctccctggcc acaaatgaag gctgcatctt ggaacacagc aaaggaggaa    180
 gcgacactgc caggtgagaa ctaggctttc tcaggggcag cgtaagcagg gtggattgag    240
 gacggtgtgg caaagggcct cctggcaaag tgctggagag aagcctcctc tttctatacc    300
 cagcccacac caaagggtag gaaacaggtt tttctagggt agccattgct agatggctgg    360
 gagacggtgg aaccgtcaga gagcagaaaa catagcccct tatcttaaat tccaagaaag    420
 caagaagttt caccaccacc tgtattagnc cggtgggtat accgaggac                469



      <210> 607
      <211> 3144
      <212> DNA
      <213> Homo sapiens


      <400> 607
 tttcttttct ttgaatgaca gaactacagc ataatgcgtg gcttcaacct gctcctcttc     60
 tggggatgtt gtgttatgca cagctgggaa gggcacataa gacccacacg gaaaccaaac    120
 acaaagggta ataactgtag agacagtacc ttgtgcccag cttatgccac ctgcaccaat    180
 acagtggaca gttactattg cacttgcaaa caaggcttcc tgtccagcaa tgggcaaaat    240
 cacttcaagg atccaggagt gcgatgcaaa gatattgatg aatgttctca aagcccccag    300
 ccctgtggtc ctaactcatc ctgcaaaaac ctgtcaggga ggtacaagtg cagctgttta    360
 gatggtttct cttctcccac tggaaatgac tgggtcccag gaaagccggg caatttctcc    420
 tgtactgata tcaatgagtg cctcaccagc agggtctgcc ctgagcattc tgactgtgtc    480
 aactccatgg gaagctacag ttgcagctgt caagttggat tcatctctag aaactccacc    540
 tgtgaagacg tggatgaatg tgcagatcca agagcttgcc cagagcatgc aacttgtaat    600
 aacactgttg gaaactactc ttgtttctgc aacccaggat ttgaatccag cagtggccac    660
 ttgagtttcc agggtctcaa agcatcgtgt gaagatattg atgaatgcac tgaaatgtgc    720
 cccatcaatt caacatgcac caacactcct gggagctact tttgcacctg ccaccctggc    780
 tttgcaccaa gcaatggaca gttgaatttc acagaccaag gagtggaatg tagagatatt    840
 gatgagtgcc gccaagatcc atcaacctgt ggtcctaatt ctatctgcac caatgccctg    900
 ggctcctaca gctgtggctg cattgtaggc tttcatccca atccagaagg ctcccagaaa    960
 gatggcaact tcagctgcca aagggttctc ttcaaatgta aggaagatgt gatacccgat   1020
 aataagcaga tccagcaatg ccaacaggga accgcagtga aacctgcata tgtctccttt   1080
 tgtgcacaaa taaataacat cttcagcgtt ctggacaaag tgtgtgaaaa taaaacgacc   1140
 gtagtttctc tgaagaatac aactgagagc tttgtccctg tgcttaaaca aatatccacg   1200
 tggactaaat tcaccaagga agagacgtcc tccctggcca cagtcttcct ggagagtgtg   1260
 gaaagcatga cactggcatc tttttggaaa ccctcagcaa atgtcactcc ggctgttcgg   1320
 acggaatact tagacattga gagcaaagtt atcaacaaag aatgcagtga agagaatgtg   1380
 acgttggact tggtagccaa gggggataag atgaagatcg ggtgttccac aattgaggaa   1440
 tctgaatcca cagagaccac tggtgtggct tttgtctcct ttgtgggcat ggaatcggtt   1500
 ttaaatgagc gcttcttcca agaccaccag gctcccttga ccacctctga gatcaagctg   1560
 aagatgaatt ctcgagtcgt tgggggcata atgactggag agaagaaaga cggcttctca   1620
 gatccaatca tctacactct ggagaacgtt cagccaaagc agaagtttga gaggcccatc   1680
 tgtgtttcct ggagcactga tgtgaagggt ggaagatgga catcctttgg ctgtgtgatc   1740
 ctggaagctt ctgagacata taccatctgc agctgtaatc agatggcaaa tcttgccgtt   1800
 atcatggcgt ctggggagct cacgatggac ttttccttgt acatcattag ccatgtaggc   1860
 attatcatct ccttggtgtg cctcgtcttg gccatcgcca cctttctgct gtgtcgctcc   1920
 atccgaaatc acaacaccta cctccacctg cacctctgcg tgtgtctcct cttggcgaag   1980
 actctcttcc tcgccggtat acacaagact gacaacaaga tgggctgcgc catcatcgcg   2040
 ggcttcctgc actacctttt ccttgcctgc ttcttctgga tgctggtgga ggctgtgata   2100
 ctgttcttga tggtcagaaa cctgaaggtg gtgaattact tcagctctcg caacatcaag   2160
 atgctgcaca tctgtgcctt tggttatggg ctgccgatgc tggtggtggt gatctctgcc   2220
 agtgtgcagc cacagggcta tggaatgcat aatcgctgct ggctgaatac agagacaggg   2280
 ttcatctgga gtttcttggg gccagtttgc acagttatag tgatcaactc ccttctcctg   2340
 acctggacct tgtggatcct gaggcagagg ctttccagtg ttaatgccga agtctcaacg   2400
 ctaaaagaca ccaggttact gaccttcaag gcctttgccc agctcttcat cctgggctgc   2460
 tcctgggtgc tgggcatttt tcagattgga cctgtggcag gtgtcatggc ttacctgttt   2520
 caccatcatc aacagcctgc agggggcctt catcttcctc atccactgtc tgctcaacgg   2580
 ccaggtacga gaagaataca agaggtggat cactgggaag acgaagccca gctcccagtc   2640
 ccagacctca aggatcttgc tgtcctccat gccatccgct tccaagacgg gttaaagtcc   2700
 tttcttgctt tcaaatatgc tatggagccc acagttggag ggacaagtag ttttccctgc   2760
 agggagccct acccctgaaa atctccttcc tcagcttaaa catgggaaat gagggatccc   2820
 cacccagccc ccagaaccct ctgggggaag gaatgttggg gggccgtctt cctgtgggtt   2880
 gtattgcact gatggaggaa atcaggtgtt tctgctccaa acggaccatt ttatcttcgt   2940
 gctctgcaac ttcttcaatt ccagagtttc tgagaacaga cccaaattca atggcatgac   3000
 caagaacacc tggctaccat tttgttttct cctgcccttg ttggtgcatg gttctaagcg   3060
 tgcccctcca gcgcctatca tacgcctgac acagagaacc tctcaataaa tgatttgtcg   3120
 cctgtctgac tgatttaccc taaa                                          3144



      <210> 608
      <211> 3144
      <212> DNA
      <213> Homo sapiens


      <400> 608
 tttcttttct ttgaatgaca gaactacagc ataatgcgtg gcttcaacct gctcctcttc     60
 tggggatgtt gtgttatgca cagctgggaa gggcacataa gacccacacg gaaaccaaac    120
 acaaagggta ataactgtag agacagtacc ttgtgcccag cttatgccac ctgcaccaat    180
 acagtggaca gttactattg cacttgcaaa caaggcttcc tgtccagcaa tgggcaaaat    240
 cacttcaagg atccaggagt gcgatgcaaa gatattgatg aatgttctca aagcccccag    300
 ccctgtggtc ctaactcatc ctgcaaaaac ctgtcaggga ggtacaagtg cagctgttta    360
 gatggtttct cttctcccac tggaaatgac tgggtcccag gaaagccggg caatttctcc    420
 tgtactgata tcaatgagtg cctcaccagc agggtctgcc ctgagcattc tgactgtgtc    480
 aactccatgg gaagctacag ttgcagctgt caagttggat tcatctctag aaactccacc    540
 tgtgaagacg tggatgaatg tgcagatcca agagcttgcc cagagcatgc aacttgtaat    600
 aacactgttg gaaactactc ttgtttctgc aacccaggat ttgaatccag cagtggccac    660
 ttgagtttcc agggtctcaa agcatcgtgt gaagatattg atgaatgcac tgaaatgtgc    720
 cccatcaatt caacatgcac caacactcct gggagctact tttgcacctg ccaccctggc    780
 tttgcaccaa gcaatggaca gttgaatttc acagaccaag gagtggaatg tagagatatt    840
 gatgagtgcc gccaagatcc atcaacctgt ggtcctaatt ctatctgcac caatgccctg    900
 ggctcctaca gctgtggctg cattgtaggc tttcatccca atccagaagg ctcccagaaa    960
 gatggcaact tcagctgcca aagggttctc ttcaaatgta aggaagatgt gatacccgat   1020
 aataagcaga tccagcaatg ccaacaggga accgcagtga aacctgcata tgtctccttt   1080
 tgtgcacaaa taaataacat cttcagcgtt ctggacaaag tgtgtgaaaa taaaacgacc   1140
 gtagtttctc tgaagaatac aactgagagc tttgtccctg tgcttaaaca aatatccacg   1200
 tggactaaat tcaccaagga agagacgtcc tccctggcca cagtcttcct ggagagtgtg   1260
 gaaagcatga cactggcatc tttttggaaa ccctcagcaa atgtcactcc ggctgttcgg   1320
 acggaatact tagacattga gagcaaagtt atcaacaaag aatgcagtga agagaatgtg   1380
 acgttggact tggtagccaa gggggataag atgaagatcg ggtgttccac aattgaggaa   1440
 tctgaatcca cagagaccac tggtgtggct tttgtctcct ttgtgggcat ggaatcggtt   1500
 ttaaatgagc gcttcttcca agaccaccag gctcccttga ccacctctga gatcaagctg   1560
 aagatgaatt ctcgagtcgt tgggggcata atgactggag agaagaaaga cggcttctca   1620
 gatccaatca tctacactct ggagaacgtt cagccaaagc agaagtttga gaggcccatc   1680
 tgtgtttcct ggagcactga tgtgaagggt ggaagatgga catcctttgg ctgtgtgatc   1740
 ctggaagctt ctgagacata taccatctgc agctgtaatc agatggcaaa tcttgccgtt   1800
 atcatggcgt ctggggagct cacgatggac ttttccttgt acatcattag ccatgtaggc   1860
 attatcatct ccttggtgtg cctcgtcttg gccatcgcca cctttctgct gtgtcgctcc   1920
 atccgaaatc acaacaccta cctccacctg cacctctgcg tgtgtctcct cttggcgaag   1980
 actctcttcc tcgccggtat acacaagact gacaacaaga tgggctgcgc catcatcgcg   2040
 ggcttcctgc actacctttt ccttgcctgc ttcttctgga tgctggtgga ggctgtgata   2100
 ctgttcttga tggtcagaaa cctgaaggtg gtgaattact tcagctctcg caacatcaag   2160
 atgctgcaca tctgtgcctt tggttatggg ctgccgatgc tggtggtggt gatctctgcc   2220
 agtgtgcagc cacagggcta tggaatgcat aatcgctgct ggctgaatac agagacaggg   2280
 ttcatctgga gtttcttggg gccagtttgc acagttatag tgatcaactc ccttctcctg   2340
 acctggacct tgtggatcct gaggcagagg ctttccagtg ttaatgccga agtctcaacg   2400
 ctaaaagaca ccaggttact gaccttcaag gcctttgccc agctcttcat cctgggctgc   2460
 tcctgggtgc tgggcatttt tcagattgga cctgtggcag gtgtcatggc ttacctgttt   2520
 caccatcatc aacagcctgc agggggcctt catcttcctc atccactgtc tgctcaacgg   2580
 ccaggtacga gaagaataca agaggtggat cactgggaag acgaagccca gctcccagtc   2640
 ccagacctca aggatcttgc tgtcctccat gccatccgct tccaagacgg gttaaagtcc   2700
 tttcttgctt tcaaatatgc tatggagccc acagttggag ggacaagtag ttttccctgc   2760
 agggagccct acccctgaaa atctccttcc tcagcttaaa catgggaaat gagggatccc   2820
 cacccagccc ccagaaccct ctgggggaag gaatgttggg gggccgtctt cctgtgggtt   2880
 gtattgcact gatggaggaa atcaggtgtt tctgctccaa acggaccatt ttatcttcgt   2940
 gctctgcaac ttcttcaatt ccagagtttc tgagaacaga cccaaattca atggcatgac   3000
 caagaacacc tggctaccat tttgttttct cctgcccttg ttggtgcatg gttctaagcg   3060
 tgcccctcca gcgcctatca tacgcctgac acagagaacc tctcaataaa tgatttgtcg   3120
 cctgtctgac tgatttaccc taaa                                          3144



      <210> 609
      <211> 3325
      <212> DNA
      <213> Homo sapiens


      <400> 609
 ctgagtcgcc tgcaggcagc gtgccaccgg ctgaagctct ggccagagct gcaggacaat     60
 ggtggggact atgtctcagc tgctttgggc cccctgacca ccctcctgga gcagggcctg    120
 ggggctcggc tgaacctgct ggctcactct cgacccccag tcccagagtg ggacatcagc    180
 caagatccac caaagcacaa agactctggg accctgaccc tgggactcct tctccggcct    240
 gagggactga ccagcgtcct tgagctgggt ccagaggcag accagcctga ggctgctaaa    300
 ttccgccagt tctggggatc ccgctcggag cttcggcgtt tccaggacgg agccattcgg    360
 gaagctgtgg tctgggaggc agcctctatg tcccagaagc gccttattcc ccaccaggtg    420
 gtcacccacc tcttggcact ccatgctgac atcccagaaa cctgtgtcca ctatgtgggg    480
 ggccccctgg atgcacttat ccaaggcctg aaagagacct ccagcacagg tgaggaggcc    540
 ctggtagcgg cggtacgttg ctacgacgac ctcagtcgcc tactgtgggg gctagagggt    600
 ctcccactga ccgtgtctgc tgttcaggga gctcacccag tgctgcgcta cacagaggtg    660
 ttcccaccaa ctccagtccg tccagccttc tccttctatg agactctgcg ggagcggtcc    720
 tcactgctgc cccggctcga taagccctgt ccggcctacg tggagcccat gaccgtggtt    780
 tgtcacctgg agggcagtgg ccagtggcca caggacgctg aggccgtgca gcgggtccga    840
 gctgccttcc agctgcgcct ggcagagctg ttgacacaac agcatggtct gcagtgccgt    900
 gccactgcca cgcacacgga tgtccttaag gatggatttg tgtttcggat tcgcgtggcc    960
 tatcagcggg agccccagat cctgaaggag gtgcagagcc cagaggggat gatctcgctg   1020
 agggacacag ctgcctccct ccgccttgag agagacacaa ggcagttgcc actgctcacc   1080
 agtgccctgc acggactgca gcagcagcac ccagccttct ctggtgtggc acggctggcc   1140
 aagcggtggg tgcgtgccca gcttcttggt gagggtttcg ctgatgagag cctggatctg   1200
 gtggccgctg cccttttcct gcaccctgag cccttcaccc ctccgagttc cccccaggtt   1260
 ggcttccttc gattcctttt cttggtatca acgtttgatt ggaagaacaa ccccctcttt   1320
 gtcaacctca ataatgagct cactgtggag gagcaggtgg agatccgcag tggcttcctg   1380
 gcagctcggg cacagctccc cgtcatggtc attgttaccc cccaagaccg caaaaactct   1440
 gtgtggacac aggatggacc ctcagcccag atcctgcagc agcttgtggt cctggcagct   1500
 gaagccctgc ccatgttaga gaagcagctc atggatcccc ggggacctgg ggacatcagg   1560
 acagtgttcc ggccgccctt ggacatttac gacgtgctga ttcgcctgtc tcctcgccat   1620
 atcccgcggc accgccaggc tgtggactcg ccagctgcct ccttctgccg gggcctgctc   1680
 agccagccgg ggccctcatc cctgatgccc gtgctgggct atgatcctcc tcagctctat   1740
 ctgacgcagc tcagggaggc ctttggggat ctggcccttt tcttctatga ccagcatggt   1800
 ggagaggtga ttggtgtcct ctggaagccc accagcttcc agccgcagcc cttcaaggcc   1860
 tccagcacaa aggggcgcat ggtgatgtct cgaggtgggg agctagtaat ggtgcccaat   1920
 gttgaagcaa tcctggagga ctttgctgtg ctgggtgaag gcctggtgca gactgtggag   1980
 gcccgaagtg agaggtggac tgtgtgatcc cagctctgga gcaagctgta gacggacagc   2040
 aggacattgg acctctagag caagatgtca gtaggatgac ctccaccctc cttggacatg   2100
 aatcctccat ggagggcctg ctggctgaac atgctgaatc atctccaaca aaacccagcc   2160
 ccaactttct ctctgatgct ccagcattgg ggcaggggca tggtggccca tgtagtctcc   2220
 tgggcctcac catcccagaa gaggagtggg agccagctca gagaaggaac tgaacccagg   2280
 agatccatcc acctattagc cctgggcctg gacctccctg cgatttccca ctcctttctt   2340
 agtcttcttc cagaaacaga gaaggggatg tgtgcctggg agaggctctg tctccttcct   2400
 gctgccagga cctgtgccta gacttagcat gcccttcact gcagtgtcag gcctttagat   2460
 gggacccagc gaaaatgtgg cccttctgag tcacatcacc gacactgagc agtggaaagg   2520
 ggctatatgt gtatgaatag accacattga aggagcacaa tgccctcctg tgttgatgcc   2580
 acttcccagg gtggagacag tggaaaagaa ccgaggacag gaaaggattg ggtaggtgaa   2640
 ggggtcaggg gactggtagt cacccaatct tggagaggtg caaaaagcac tgggggctac   2700
 ccgttagctg catctgccct ggctgtttgc ccgttcatgt cacaaactgc cactactatg   2760
 tacctgcagt ggggttgcag agatggggga gactcaagtc ttactcccca ggagctccca   2820
 gggcccaagg aggagaatgc tgcctccttt cagtctggtc tacacccact ttctggtagc   2880
 ctctctgctt cctgtaattc tggctgtttt tccagactca gctcaaatag tgcccctcct   2940
 taagcccatc cctcgccccc agcctgaggt gatctttccc tcctctgaac tattagagca   3000
 gttactgtct gttcagttcg tttggcaggc acacacagtg gcataaattc tattgttttg   3060
 aactctgatt taaaattaaa ttgcagctgg gcgtagtggc tcatgcttgt aatcccaaca   3120
 cttagggagt caggagaatc acttgagctc aggagttcta gaccaatctg ggcaacagag   3180
 agaccccatc tcttttaaat aaaaagttaa attgcttaat ttcccccgta ttcctggcct   3240
 gtctgcccct ttcacataat tttaacctgg tttcttgtat gtaaactcct tgagggcaag   3300
 aacatgtttg aacataaaaa aaaaa                                         3325



      <210> 610
      <211> 861
      <212> DNA
      <213> Homo sapiens


      <400> 610
 tcgactcttt cgtcccgagc gcgggacgcg gcgccctggg ggaggagggc gaagcgacgc     60
 ggcgatggct ccgcgggcac tcccggggtc cgccgtccta gccgctgctg tcttcgtggg    120
 aggcgccgtg agttcgccgc tggtggctcc ggacaatggg agcagccgca cattgcactc    180
 cagaacagag acgaccccgt cgcccagcaa cgatactggg aatggacacc cagaatatat    240
 tgcatacgcg cttgtccctg tgttctttat catgggtctc tttggcgtcc tcatttgcca    300
 cctgcttaag aagaaaggct atcgttgtac aacagaagca gagcaagata tcgaagagga    360
 aaaggttgaa aagatagaat tgaatgacag tgtgaatgaa aacagtgaca ctgttgggca    420
 aatcgtccac tacatcatga aaaatgaagc gaatgctgat gtcttaaagg cgatggtagc    480
 agataacagc ctgtatgatc ctgaaagccc cgtgaccccc agcacaccag gggagcccgc    540
 cagtgagtcc tgggcctttg tcaccagggg ggacgccagg gaagcacgtc tgtggccatc    600
 atctgcatac ggtgggcggt gttgtcgaga gggatgtgtg tcatcggtgt aggcacaagc    660
 ggtggcactt tataaagccc actaacaagt ccagagagag cagaccacgg cgccaaggcg    720
 aggtcacggt cctttctgtt ggcagattta gagttacaaa agtggagcac aagtcaaacc    780
 acaaggaacg gagaagcctg atgtctgtta atggggctga aaccgtccat ggggaggtgc    840
 cggcaacaac ttgtgagaga a                                              861



      <210> 611
      <211> 1690
      <212> DNA
      <213> Homo sapiens


      <400> 611
 tttctgatac tcagaagact cagagactgt cagtttaaaa aatgaaagta atatagaagg     60
 ggcaaagtgg catttatcat tctatctctc caggctcctg tctctttaat cagctagcct    120
 gatttgccca gtaaatgatt cctgagagtg tgtgtgcgtg tgtgtgtgtg tgtgtgcccg    180
 cgcgcgtgtg ttgtagctct gtcaatcctt ggattagaac caatgattgc agcttgtagg    240
 agggctgtcc agggccagat tgtacaatgt gtctcagtgc cagagtatga gtggagataa    300
 ttacggagaa gtcatactct ctcacaccct cggctttctt gttgtgtcct tcagcaaaac    360
 agtggattta aatctccttg cacaagcttg agagcaacac aatctatcag gaaagaaaga    420
 aagaaaaaaa ccgaacctga caaaaaagaa gaaaaagaag aagaaaaaaa atcatgaaaa    480
 ccatccagcc aaaaatgcac aattctatct cttgggcaat cttcacgggg ctggctgctc    540
 tgtgtctctt ccaaggagtg cccgtgcgca gcggagatgc caccttcccc aaagctatgg    600
 acaacgtgac ggtccggcag ggggagagcg ccaccctcag gtgcactatt gacaaccggg    660
 tcacccgggt ggcctggcta aaccgcagca ccatcctcta tgctgggaat gacaagtggt    720
 gcctggatcc tcgcgtggtc cttctgagca acacccaaac gcagtacagc atcgagatcc    780
 agaacgtgga tgtgtatgac gagggccctt acacctgctc ggtgcagaca gacaaccacc    840
 caaagacctc tagggtccac ctcattgtgc aagtatctcc caaaattgta gagatttctt    900
 cagatatctc cattaatgaa gggaacaata ttagcctcac ctgcatagca actggtagac    960
 cagagcctac ggttacttgg agacacatct ctcccaaagc ggttggcttt gtgagtgaag   1020
 acgaatactt ggaaattcag ggcatcaccc gggagcagtc aggggactac gagtgcagtg   1080
 cctccaatga cgtgggccgc gcccgtgggt acggagagta aaggtcaccg tgaactatcc   1140
 accatacatt tcagaagcca agggtacagg tgtccccgtg ggacaaaagg ggacactgca   1200
 gtgtgaagcc tcagcagtcc cctcagcaga attccagtgg tacaaggatg acaaaagact   1260
 gattaaggaa agaaaggggt gaaagtggaa aacagacctt tcctctcaaa actcatcttc   1320
 ttcaatgtct ctgaacatga ctatgggaac tacacttgcg tggcctccaa caagctgggc   1380
 cacaccaatg ccagcatcat gctatttggt ccaggcgccg tcagcgaggt gagcaacggc   1440
 acgtcgagga gggcaggctg cgtctggctg ctgcctcttc tggtcttgca cctgcttctc   1500
 aaattttgat gtgagtgcca cttccccacc cgggaaaggc tgccgccacc accaccacca   1560
 acacaacagc aatggcaaca ccgacagcaa ccaatcagat atatacaaat gaaattagaa   1620
 gaaacacagc ctcatgggac agaaatttga gggaggggaa caaagaatac tttgggggga   1680
 aaagagtttt                                                          1690



      <210> 612
      <211> 1484
      <212> DNA
      <213> Homo sapiens


      <400> 612
 tttttttttt ttcatgcttt ttccctttcc cttttttttt ttttaaacaa gcagctcagc     60
 gatttgggag gttggttagt acaatacaga gaacacagag agaaagtata aaatggcact    120
 gaacactaat gccaatactt atctcattgt ggttataacg aaggatatta ttatttgtgt    180
 tatttttgtc tggaacataa atcaatgcca ttaacttgaa cttgaggtat atacacaata    240
 cacacacaac cttaagcaaa atacttttca taagtaacat tacattttaa aatattggaa    300
 acattcgaat atctgtgctg atttgtattc tgacttaatg gaacaagaag aaaataacat    360
 tcaactaggg agggttaaac tgataataaa gctcttaaaa ttcaaaatgt cttcctctcc    420
 ctttgtactt accataggct acacaatgtc ctgagaggat tcattatgag aaaaatgtca    480
 atcacagctt caataactta ctttggaaaa aactaatgag aaagcaaact ggaaggtgag    540
 acttcatctt tgttttcaaa taagtggtct taatttttct tcttatagaa aaagtttaaa    600
 tcagtttatt ataaatatat ctaaaccatt aatttttgca gctttcaggt aaagtccagc    660
 acttcattta tacaaaatct atgagaagag gtcagtagag atcatctaat cttaagtcgt    720
 gacatcatcc attcaagtcc ttggcacaat ccctcgccag ttagagcaca gcatgcctgg    780
 atatgccact ggtgatcttt aatagaagtt agcttcaaaa actgggagat ttctgctaca    840
 gtcatgcatt ctttaacatc ttgtttatta gcaaaaatca gcaatccagc ttttcttagg    900
 tcctcatgcg ctaacatttt atagagttct tctctagtta cagaaatcct ctctctgtct    960
 gtactgtcca caacaactat tacaaactct gtgttagtat agtaagtgtt ccaggaagaa   1020
 cgaagagatt cttggccacc aatatcccac attaggaaac gtgtattatt aatcactatc   1080
 tcttctacat tacttcctat tgtaggagat gtatgtacaa cttcattcat agaaaattgg   1140
 taaagaatgg tagttttccc tgcattatcc agcccaacaa tgataacttt gtgctcctgg   1200
 tgattgaaca gtctccatat tctagtgaag agaattccca ttctcgggca gcggaccccc   1260
 ccccctccag acacccgggc cgcctggctt cccccggctc aggctgaggg ggaggagaga   1320
 gacgcgctgg agcctccgcc tctgctgctg ctcccgcgct ggtcgcgggc ccgcttccag   1380
 ggaaccggag ggaggccgaa gcccaggccg ccctgccgcg cgcaaggccc cgccgctgcc   1440
 gccgcggcac tcgcctggct cgcggacatc gccgccgcgt tgtc                    1484



      <210> 613
      <211> 5597
      <212> DNA
      <213> Homo sapiens


      <400> 613
 aatcttggct gttctccagg gttttttttt tgtgttaatg ctttaatatg tggaccaagt     60
 gacacacatt acagaatctc cccttccctc tgtctcttac agttttgcgt ttggctccct    120
 aatatctgct gtcgatccag tggccactat tgccattttc aatgcacttc atgtggaccc    180
 cgtgctcaac atgctggtct ttggagaaag tattctcaac gatgcagtct ccattgttct    240
 gaccaacaca gctgaaggtt taacaagaaa aaatatgtca gatgtcagtg ggtggcaaac    300
 atttttacaa gcccttgact acttcctcaa aatgttcttt ggctctgcag cgctcggcac    360
 tctcactggc ttaatttctg cattagtgct gaagcatatt gacttgagga aaacgccttc    420
 cttggagttt ggcatgatga tcatttttgc ttatctgcct tatgggcttg cagaaggaat    480
 ctcactctca ggcatcatgg ccatcctgtt ctcaggcatc gtgatgtccc actacacgca    540
 ccataacctc tccccagtca cccagatcct catgcagcag accctccgca ccgtggcctt    600
 cttatgtgaa acatgtgtgt ttgcatttct tggcctgtcc atttttagtt ttcctcacaa    660
 gtttgaaatt tcctttgtca tctggtgcat agtgcttgta ctatttggca gagcggtaaa    720
 cattttccct ctttcctacc tcctgaattt cttccgggat cataaaatca caccgaagat    780
 gatgttcatc atgtggttta gtggcctgcg gggagccatc ccctatgccc tgagcctaca    840
 cctggacctg gagcccatgg agaagcggca gctcatcggc accaccacca tcgtcatcgt    900
 gctcttcacc atcctgctgc tgggcggcag caccatgccc ctcattcgcc tcatggacat    960
 cgaggacgcc aaggcacacc gcaggaacaa gaaggacgtc aacctcagca agactgagaa   1020
 gatgggcaac actgtggagt cggagcacct gtcggagctc acggaggagg agtacgaggc   1080
 ccactacatc aggcggcagg accttaaggg cttcgtgtgg ctggacgcca agtacctgaa   1140
 ccccttcttc actcggaggc tgacgcagga ggacctgcac cacgggcgca tccagatgaa   1200
 aactctcacc aacaagtggt acgaggaggt acgccagggc ccctccggct ccgaggacga   1260
 cgagcaggag ctgctctgac gccaggtgcc aaggcttcag gcaggcaggc ccaggatggg   1320
 cgtttgctgc gcacagacac tcagcagggg cctcgcagag atgcgtgcat ccagcagccc   1380
 cttcaagaca taagagggcg gggcgaggta ctggctgcag agtcgcctta gtccagaacc   1440
 tgacaggcct ctggagccag gcgacttctt gggaaactgt catctcccga ctcctccctg   1500
 agccagcctc cgctcagtgt ggctcctcag cccacagagg ggagggagca tggggccagg   1560
 tgccagtcat ctgtgaagct agggcgccta cccccccacc cggaggaccc ctgcggcccc   1620
 ctgcctagag gagcaccatc tacagttgtg ccattcccca gccactgcct tcatgctgcc   1680
 cccgccggac tggcagagcc agggggtcag ccacctgcct ttgagtcatc aagatgcctc   1740
 tgcagccaca attctgacct aagtggcagg gcccagaaat cctgaaaacc tcccgctgcc   1800
 ttttgtgata cttcctgtgc tccctcagag agaaacggag tgaccttttg tcctttacct   1860
 gattggcact tcgcagtcta tctccctggg tagcagacgg ctgctgccct tctctgggca   1920
 tgttctgaat gtttacactg gtaccttctg gtatcttctt tagagccccc tgcaagctgc   1980
 aactctaggc ttttatcttg cggggtcaga gcgccctcta gagggaaaag ctagaggcac   2040
 agggtttctg ccggcccaca actgctgtct tgatttgcat tttacagcaa agtgctgaga   2100
 gcctctagtc gcctcctgcc atctgatctc cctccccacc attcccgtac tcagttgttc   2160
 ttttgtctaa tcggaggcca ctgtgctgag gccctgcagt gtctgctcac tgctgccatc   2220
 ttcgctgcta gtcagggttc catcctcttt cccctctccc agttccctac cacgttggat   2280
 cccattcgtc acccatgcta gggtccccaa agcactgggg caggggccag agcagcagca   2340
 cccagagctc cctcctctac tctgacctgg ggccccagca tcctggagca cacgctccac   2400
 gcacacacac cccagccctg tcccaggggc ctggccccct cagccatctc agggtgagga   2460
 gctgccagtc atgtccagat ggaatgactc ccatcctctc ctcatctccc ctttgacgag   2520
 cctcaaactg ctcagctcat caaagagcca ttgccaactt ccgtatgtgg ttctgggtcc   2580
 cagggagcct tggaacctgg caccctgggg tggtttaatt catcattaag aagcattcct   2640
 gcttctcaag ggacacagtg gcctgcatgg gccagcatgg accctgggct gatcatgtgc   2700
 attcctgctt ctctggggac acagtgggcc cacatgggcc agcatggacc ctgggctaga   2760
 gcaagcacat ctccatctct tccacctcag gcagtgtggc tccagatgtc aggagggact   2820
 gacctcagga ccttccaggt tcctctgtgc caggaatgag aggccaggcc cgatcctacc   2880
 acctcgcctt gaccctgaag tcagagcagg ccagccaagc aggaagcaca ctgtttactt   2940
 tttgcatgaa aagtaaatgt gtacttgata gagctaaaat atgatctttt ttaatttctc   3000
 aaccccataa tttgagccat tgccttgctt aattttggtt tccaccattt ccttttagtg   3060
 gagaagagag gaagtcagag ggtagggacc tttgcctgcc cctgggcgag tgcgggcagg   3120
 gatctgagac cagattgttc tcgcacccct gccagaactc actctcccct gaagtttagg   3180
 gtcccatctc ccagatgtaa gttgttttgc aaactcagtt tgccaggatt tctttctttc   3240
 ctaatcttaa attcacagat aaagcaatga aaagagtcag atcccatttc cgtctgcccc   3300
 ctcgtcacca ggtgtgatag ccccagccag gtcacacctg gcctcacact ttgagctgag   3360
 acttgaaaac gatgctgtgg cggaagagca tgtggggctt ggtggagggg ccccaggatt   3420
 tgttgggggc aaagggggtg gcgggaccgt tcccaggagg taccagcacc tgcctcgatc   3480
 tcctctgagc ctcttctgcc ccctgtcggc caggtgaggt cagcagcctg ggagagtgcc   3540
 cccaagagat gagggcaccc cgtgttcctt ggcaatcttg gctcaccttg gtaacaaaag   3600
 gccatagaag tctgtttttc tgggtcagtt ttttttgcct gagaataaca aattgctgct   3660
 gtctaccttt agcacaccca ataattctat ttggggcagt gaatgcatag aagatataaa   3720
 aatacgcagc ttaactatat cttcctgcgt gtgtatttat tttcttctgg gtctaggcca   3780
 tggtacagga gaactgtggc gtgtaggagg aatacttcag gatgagtgaa ggctggagcc   3840
 agggagcgct ggaggaaacc agccctttag ccagcagccc ctccaccaca ggcactgctg   3900
 tgtggaacga gttcttggaa tgaatcccat gctttctgca gcctgtagtt gttatgaccc   3960
 ctcggaacaa ccaccccgtg gcttgtgtgg ggtctcgcag ggaaaagggc tggcttctag   4020
 gtccccgaga taagtgtgca gggggatggg ccagggccag gctaagggtg gctcagttcc   4080
 atcatctgga ggtcagacac actgtccaga ggcagaactg aagccctctc ggcccctacc   4140
 ctaagccagc cacccctctt cacagtgggt gagctgggct gggctggctg gcatgaggcc   4200
 aaggggtagg cctgagcgcc agagtcgccc aggttagccc acaggattcc tttgtgtgcc   4260
 atggaatgct gaaagatggg tgactgggga cccttcttaa aacctttggc aaaggtgcca   4320
 tcggcagggc ttggcctcat gaagtctcag gtccgtgttc ccgcagggcg cacatgcttg   4380
 gagagtcctc agcagggtag ccgaggccag gccacttctg ctgaggatgg ggcaggctgg   4440
 ggtgtgggtg tggcctgggg tggctcaggt ctggaactgc tgcctgattc ctgtgtgggg   4500
 agaagctcag tggccgtttg ctgccactga caaggatttc acatgcagaa gagaaaaggc   4560
 ccccctccac cccccgcatt ccctgccgag tgagagccag tgtttgctgc ccttgctggg   4620
 ggcgggtagg aaaccctgag cttcctgatg cggagtcatg aagcagagtc ctcgggaagg   4680
 catctccaca gccccgggtc ctctgtctaa cgccctccat ttcacgccct ccatctcaca   4740
 gtcaagataa aggcctcgag aataaagagc cagccccctt ccatttagtc tcctgccgtt   4800
 tcccaaacag ttgtccaaca gttagacatt gaggggcttc actgttacca ggcatgtaac   4860
 agaaggagga agactaacac acaccccctg ccccatccca tccccctctc ccgagctatt   4920
 ttcttgctgt ggcctctggt gcccttgagt tggtctcccc ggctgctctg cgggggcttc   4980
 actggcttcg gagtgagcgc gaagtgctgg tgagcagtgg gcctgtgatt ggatgggaag   5040
 atgtgcatcc gtggtcaaaa gtcagctgcc agccctgcgg aaccagagcc tcaggctggg   5100
 atgggggagg cctccctgct ttcacctgca tggggggcat ggcctggctt acaccaaagg   5160
 ctttgacggt ttctccaagt aaggatctgc aaatcttgaa tcgtcctcaa aatgacgaag   5220
 cttgaattgt cctcaagatg gatgtgaatc ttacattcct tttcatcatt tcctttgtaa   5280
 aaatgacgag tgcctgggtt tttgttttaa gaagcattat gaaggccaga cttactcatt   5340
 tttctccccc aagtgagctg caagaggccc ctgttaggcc cctgtttcct gagcagtgat   5400
 gtgctgctct tcttggtggg gctttgggct gggaggggaa ggcgggtcag agatggggga   5460
 cctgtggctg ccatgcagga gcccctgcgt catctcgttg gactctttaa gggagtcagg   5520
 aatagatgta tgaacagtcg tgtcactgga tgcctattta gaaataaagt gtatgctgct   5580
 gaattggaaa aaaaaaa                                                  5597



      <210> 614
      <211> 2065
      <212> DNA
      <213> Homo sapiens


      <400> 614
 cggacgcgtg ggctcgcgta gccgtgcgcc gattgcctct cggcctgggc aatggtcccg     60
 gctgccggtc gacgaccgcc ccgcgtcatg cggctcctcg gctggtggca agtattgctg    120
 tgggtgctgg gacttcccgt ccgcggcgtg gaggttgcag aggaaagtgg tcgcttatgg    180
 tcagaggagc agcctgctca ccctctccag gtgggggctg tgtacctggg tgaggaggag    240
 ctcctgcatg acccgatggg ccaggacagg gcagcagaag aggccaatgc ggtgctgggg    300
 ctggacaccc aaggcgatca catggtgatg ctgtctgtga ttcctgggga agctgaggac    360
 aaagtgagtt cagagcctag cggcgtcacc tgtggtgctg gaggagcgga ggactcaagg    420
 tgcaacgtcc gagagagcct tttctctctg gatggcgctg gagcacactt ccctgacaga    480
 gaagaggagt attacacaga gccagaagtg gcggaatctg acgcagcccc gacagaggac    540
 tccaataaca ctgaaagtct gaaatcccca aaggtgaact gtgaggagag aaacattaca    600
 ggattagaaa atttcactct gaaaatttta aatatgtcac aggaccttat ggattttctg    660
 aacccaaacg gtagtgactg tactctagtc ctgttttaca ccccgtggtg ccgcttttct    720
 gccagtttgg cccctcactt taactctctg ccccgggcat ttccagctct tcactttttg    780
 gcactggatg catctcagca cagcagcctt tctaccaggt ttggcaccgt agctgttcct    840
 aatattttat tatttcaagg agctaaacca atggccagat ttaatcatac agatcgaaca    900
 ctggaaacac tgaaaatctt catttttaat cagacaggta tagaagccaa gaagaatgtg    960
 gtggtaactc aagccgacca aataggccct cttcccagca ctttgataaa aagtgtggac   1020
 tggttgcttg tattttcctt attcttttta attagtttta ttatgtatgc taccattcga   1080
 actgagagta ttcggtggct aattccagga caagagcagg aacatgtgga gtagtgatgg   1140
 tctgaaagaa gttggaaaga ggaacttcaa tccttcgttt cagaaattag tgctacagtt   1200
 tcatacattt tctccagtga cgtgttgact tgaaacttca ggcagattaa aagaatcatt   1260
 tgttgaacaa ctgaatgtat aaaaaaatta taaactggtg ttttaactag tattgcaata   1320
 agcaaatgca aaaatattca atagatgcac tattcttgtt tttactgcat gaacgtaatc   1380
 cagtatttgg aaagtaatcc agtttgaaat gtgaagatgt attccggcag aatagtgagt   1440
 agaatgacat gcttactata cagaaggcaa aaataggact ctcaggtaat agtttaagga   1500
 aacccttgat tccttatata tgtttaagaa ggttagtttt ctgtttcttt gcagtttttc   1560
 ttctagagtc catagcagga aagtatgtaa ccagaattgg ttagtgtgac cccctcaagt   1620
 agcaagtgat ggaaaataag agtcaaatac cttgatgttt gtgatctcta actcaaaaaa   1680
 tttgaagtgt tttaagttgt ttctgggtaa gggagatgtt aggagaaagg aaatgctgta   1740
 actaaagctc aattattatc agttctatgc taacgtatac attttaatca tagttaccta   1800
 agcagcatgc attaattgaa ccttaaaatg ttcccactgc gcctggccta aacaaacttt   1860
 ttgaaaagct gtttctaaaa gattccttaa attcagatat gacagctaat tacctcatca   1920
 taaattactt ttatactaat tgtttccagg gttttagagt agttgaatgt ttatttcaca   1980
 aggcacccta aattctatag aaataaaacc tcagatgagt ctccttctta gagtgttaca   2040
 atgaatggga gtttacactt ttatg                                         2065



      <210> 615
      <211> 795
      <212> DNA
      <213> Homo sapiens


      <400> 615
 gcatgcgtaa ttcgccacca ggttcaacgc ggggcccatt gacaccacta tcatcatgaa     60
 tgggaggcag atccagtgcc ttgcacccac gtctaccgag gtcctgagga ggagggtgac    120
 atgctggacc cagggctggt gatgactgga accaagtgtg gctacaacca tatttgcttt    180
 gaggggcagt gcaggaacac ctccttcttt gaaactgaag gctgtgggaa gaagtgcaat    240
 ggccatgggg tctgtaacaa caaccagaac tgccactgcc tgccgggctg ggccccgccc    300
 ttctgcaaca caccgggcca cgggggcagt atcgacagtg ggcctatgcc ccctgagagt    360
 gtgggtcctg tggtagctgg agtgttggtg gccatcttgg tgctggcggt cctcatgctg    420
 atgtactact gctgcagaca gaacaacaaa ctaggccaac tcaagccctc agctctccct    480
 tccaagctga ggcaacagtt cagttgtccc ttcagggttt ctcagaacag cgggactggt    540
 catgccaacc caactttcaa gctgcagacg ccccagggca agcgaaaggt gatcaacact    600
 ccggaaatcc tgcggaagcc ctcccagcct cctccccggc cccctccaga ttatctgcgt    660
 ggtgggtccc cacctgcacc actgccagct cacctgagca gggctgctag gaactcccca    720
 gggcccgggt ctcaaataga gaggacggag tcgtccagga ggcctcctcc aagccggcca    780
 attccccccg caccc                                                     795



      <210> 616
      <211> 511
      <212> DNA
      <213> Homo sapiens


      <400> 616
 cccacgcgtc cggtttcatg ttgaagaaaa tcagtgttgg ggttgcagga gacctaaaca     60
 cagtcaccat gaagctgggc tgtgtcctca tggcctgggc cctctacctt tcccttggtg    120
 tgctctgggt ggcccagatg ctactggctg ccagttttga gacgctgcag tgtgagggac    180
 ctgtctgcac tgaggagagc agctgccaca cggaggatga cttgactgat gcaagggaag    240
 ctggcttcca ggtcaaggcc tacactttca gtgaaccctt ccacctgatt gtgtcctatg    300
 actggctgat cctccaaggt ccagccaagc cagtttttga aggggacctg ctggttctgc    360
 gctgccaggc ctggcaagac tggccactga ctcaggtgac cttctaccga gatggctcag    420
 ctctgggtcc ccccgggcct aacagggaat tcttccatcc accggtgggt aacaaaaggg    480
 cagacaagcc gggcaactaa ccaattgcag t                                   511



      <210> 617
      <211> 511
      <212> DNA
      <213> Homo sapiens


      <400> 617
 cccacgcgtc cggtttcatg ttgaagaaaa tcagtgttgg ggttgcagga gacctaaaca     60
 cagtcaccat gaagctgggc tgtgtcctca tggcctgggc cctctacctt tcccttggtg    120
 tgctctgggt ggcccagatg ctactggctg ccagttttga gacgctgcag tgtgagggac    180
 ctgtctgcac tgaggagagc agctgccaca cggaggatga cttgactgat gcaagggaag    240
 ctggcttcca ggtcaaggcc tacactttca gtgaaccctt ccacctgatt gtgtcctatg    300
 actggctgat cctccaaggt ccagccaagc cagtttttga aggggacctg ctggttctgc    360
 gctgccaggc ctggcaagac tggccactga ctcaggtgac cttctaccga gatggctcag    420
 ctctgggtcc ccccgggcct aacagggaat tcttccatcc accggtgggt aacaaaaggg    480
 cagacaagcc gggcaactaa ccaattgcag t                                   511



      <210> 618
      <211> 1034
      <212> DNA
      <213> Homo sapiens


      <400> 618
 ctccccacgc atccaaacaa gcagacgggg taccagcctc ctggtgtgta tcataggatt     60
 tgttcacata gtgttatgca tgatcttcgt aaggttaaga agccgtggtg gtgcaccatg    120
 acatccaacc cgtatatata aagataaata tatatatata tgtatgtaaa ttatagcact    180
 gagggccctg ctgccctgct ggaccaagca aaactaagcc ttttggtttg ggtattatgt    240
 ttcgttttgt tatttgtttg tttttgtggc ttgtcttatg tcgtgatagc acaagtgcca    300
 gtcggattgc tctgtattac agaatagtgt ttttaattca tcaatgttct agttaatgtc    360
 tacctcagca cctcctctta gcctaatttt aggaggttgc ccaattttgt ttcttcaatt    420
 ttactggtta cttttttgta caaatcaatc tctttctctc tctcctcccc acctctcacc    480
 cttgccctct ccatctccct ctcccgccct cccctcctcc ctctggctcc ccgtctcatt    540
 tctgtccact ccattctctc tccctctctc ctgcctcctg ctgccccctc cccagcccac    600
 ttccccgagt tgtgcttgcc gctccttatc tgttctagtt ccgaagcagt ttcactcgaa    660
 gttgtgcagt cctggttgca gctttccgca tctgccttcg tttcgtgtag attgacgcgt    720
 ttctttgtaa tttcagtgtt tctgacaaga tttaaaaaaa aaaaaaagga aaaaaaaaga    780
 aaaaatgaat ttactgctgc aggttttttt ctctctccat gtgtcactaa gtgaagtttg    840
 tgccttctat agcaaagaga atatttttta catcctacta acagtagatt tttttgtagt    900
 gaacattttt tgtattttta tttataagtc tcataagaaa aatagcaatg ttcagttgta    960
 taccttgaat ctgcagttag aagagaataa agttaattca gttgtctctc gaaaaaaaaa   1020
 aaaaagtcga cgcg                                                     1034



      <210> 619
      <211> 2029
      <212> DNA
      <213> Homo sapiens


      <400> 619
 gcggccgcct ggagctctcg gcctcggcct tcgacgacgg caacttctcg ctgctcatcc     60
 gcgcggtgga ggagacggac gcggggctgt acacctgcaa cctgcaccat cactactgcc    120
 acctctacga gagcctggcc gtccgcctgg aggtcaccga cggccgtgag tgcttccccc    180
 ccgcccccca gctcccgccc ctcgaccctc gaccgccgcc ccggcccgcg cgccgctgac    240
 cgcgccccct ccgcagcccc ggccaccccc gactactggg acggcgagaa ggaggtgctg    300
 gcggtggcgc gcggcgcacc cgcgcttctg acctgcgtga accgcgggca cgtgtggacc    360
 gaccggcacg tggaggaggc tcaacaggtg gtgcactggg accggcagcc gcccggggtc    420
 ccgcacgacc gcgcggaccg cctgctggac ctctacgcgt cgggcgagcg ccgcgcctac    480
 gggccccttt ttctgcgcga ccgcgtggct gtgggcgcgg atgcctttga gcgcggtgac    540
 ttctcactgc gtatcgagcc gctggaggtc gccgacgagg gcacctactc ctgccacctg    600
 caccaccatt actgtggcct gcacgaacgc cgcgtcttcc acctgacggt cgccgaaccc    660
 cacgcggagc cgcccccccg gggctctccg ggcaacggct ccagccacag cggcgcccca    720
 ggcccagacc ccacactggc gcgcggccac aacgtcatca atgtcatcgt ccccgagagc    780
 cgagcccact tcttccagca gctgggctac gtgctggcca cgctgctgct cttcatcctg    840
 ctactggtca ctgtcctcct ggccgcccgc aggcgccgcg gaggctacga atactcggac    900
 cagaagtcgg gaaagtcaaa ggggaaggat gttaacttgg cggagttcgc tgtggctgca    960
 ggggaccaga tgctttacag gagtgaggac atccagctag attacaaaaa caacatcctg   1020
 aaggagaggg cggagctggc ccacagcccc ctgcctgcca agtacatcga cctagacaaa   1080
 gggttccgga aggagaactg caaataggga ggccctgggc tcctggctgg gccagcagct   1140
 gcacctctcc tgtctgtgct cctcggggca tctcctgatg ctccggggct cacccccctt   1200
 ccagcggctg gtcccgcttt cctggaattt ggcctgggcg tatgcagagg ccgcctccac   1260
 acccctcccc caggggcttg gtggcagcat agcccccacc cctgcggcct ttgctcacgg   1320
 gtggccctgc ccacccctgg cacaaccaaa atcccactga tgcccatcat gccctcagac   1380
 ccttctgggc tctgcccgct gggggcctga agacattcct ggaggacact cccatcagaa   1440
 cctggcagcc ccaaaactgg ggtcagcctc agggcaggag tcccactcct ccagggctct   1500
 gctcgtccgg ggctgggaga tgttcctgga ggaggacact cccatcagaa cttggcagcc   1560
 ttgaagttgg ggtcagcctc ggcaggagtc ccactcctcc tggggtgctg cctgccacca   1620
 agagctcccc cacctgtacc accatgtggg actccaggca ccatctgttc tccccaggga   1680
 cctgctgact tgaatgccag cccttgctcc tctgtgttgc tttgggccac ctggggctgc   1740
 accccctgcc ctttctctgc cccatcccta ccctagcctt gctctcagcc accttgatag   1800
 tcactgggct ccctgtgact tctgaccctg acacccctcc cttggactct gcctgggctg   1860
 gagtctaggg ctggggctac atttggcttc tgtactggct gaggacaggg gagggagtga   1920
 agttggtttg gggtggcctg tgttgccact ctcagcaccc cacatttgca tctgctggtg   1980
 gacctgccac catcacaata aagtccccat ctgattttta aaaaaaaaa               2029



      <210> 620
      <211> 1446
      <212> DNA
      <213> Homo sapiens


      <400> 620
 ccgggtcgac gatttcgtca ggagaagcca aacttggtcc cccggctcgc ggagtgcctg     60
 cgagcggtgc tcatggcgct ctatgagctc ttctctcacc cggtcgagcg cagttaccgc    120
 gcggggctct gctccaaagc cgcgctgttc ctgctgctgg ccgctgcgct cacgtacatc    180
 ccgccgctgc tggtggcctt ccggagccac gggttttggc tgaagcggag cagctacgag    240
 gagcagccga ccgtgcgctt ccaacaccag gtgctgctcg tggccctgct cggacccgaa    300
 agcgacgggt tcctcgcctg gagcacgttc cccgccttca accggcagca aggggatcgc    360
 ctgcgcgtcc cgctcgtttc gtggaggaga taatgcctgt tgtgtacagc aagacagtgg    420
 gtcattgtgt atgtacagaa gtgatgtgga ttcctcccag actcattagt gaccagggct    480
 gctgggcctg tttgggtttc ctagactaga gaagaagaca ggaaccagga tgggaagacg    540
 gacatgttac attttaagct ggagcttccc ctgcagtcca cggagcacgt tctcggtgtg    600
 cagctcatcc tgactttctc ctatcgatta cacaggatgg cgaccctcgt gatgcagagc    660
 atggcgtttc tccagtcctc ctttcctgtc ccgggatccc agttatacgt gaacggagac    720
 ctgaggctgc agcagaagca gccgctgagc tgtggtggcc tagatgcccg atacaacgta    780
 agagcgcttc tcattgtcca gctcctttgt ttctctgtgt tactgttcat taagttcttt    840
 aaagagggga atgaaaagta gaaatgtcag gccaggcgca gtggctcatg cctgtaatcc    900
 cagcactttg ggaggcggag gtgggtggat cacttgaggt caggagtttg agaccagcct    960
 ggccaacatg gtgaaaccct gtctctacta caaaatacaa aaaaattagc tgggcatggt   1020
 gatgggcgcc tgtaatccca gctacttggg aggctgaggc aggagaatcg cttgaaccca   1080
 ggaggcagaa gttgcagtga gccaagatca tgccactgca ctccagcctg ggcaacaggg   1140
 taggactcca tccacacaca cacacacaca caaaattgaa aagtgaagac attttaatgg   1200
 agatttaata gtgcttccag actaatgaac taatggagtt ttggctccac tcatgagtgt   1260
 atttgaaatg taagtaacca gctacaaaga ataatgtcac ttcatttgat tatgactacc   1320
 aatcaagaga aggaggaata catttctgag gagtgatact taaaccattt gagcttaaat   1380
 gagtacctga ttttgcagcc attaaaaatg tgttcattaa ctatgtgggg aattattgga   1440
 aaattt                                                              1446



      <210> 621
      <211> 589
      <212> DNA
      <213> Homo sapiens


      <400> 621
 ccatcattac gcctagcttg gcacgaggat ctacgacatc tacgccatgt tcctctgtca     60
 ctggcacaag caccaggtca aagggcatgg aggggacgac ggagcggcca gagccccggg    120
 cagcacgtgg gccatagcgc gtggctacct gcacaaggag ttcctcatgg tgctccacca    180
 tgccgccatg gtgctggtgt gcttcccact ctcagtggtg tggcgacagg gtaagggaga    240
 cttctttctg ggttgcatgt tgatggcaga ggtcagcacg cccttcgtct gccttggcaa    300
 gatcctcatc cagtacaagc agcagcacac actgctgcac aaggtgaacg gggccctgat    360
 gctgctcagc ttcctctgct gccgggtgct gctctttccc tacctgtact gggcctacgg    420
 gcgccatgcc ggcctgcccc tgctggccgt gcccctggcc atccctgccc acgtcaacct    480
 gggcgctgcg ctgctcctgg cccctcaact ctactgggtc ttcctcatat gccggggggc    540
 ctgccgccta ttttggcccc gctcccggac gcccacggac tggcaaggc                589



      <210> 622
      <211> 622
      <212> DNA
      <213> Homo sapiens


      <400> 622
 gtcctgatcg attcggcacg agcgacagcc gcgggtgcgt ggtcgtgcgg caagtgagcg     60
 atttggtgaa cagacactcc cttctgtagc catggattgt tacagaactt cactaagcag    120
 ttcctggatt taccccactg tgatcctctg cttatttggt tttttctcca tgatgagacc    180
 ctcagaacca ttccttatcc catatttatc tggaccagat aaaaacctga ccagtgcaga    240
 gataacaaat gagatcttcc ccgtttggac atactcctac ctggtgctgc tgctgcctgt    300
 gtttgtcctc accgattatg tccgctacaa gccagtcatc atcttgcaag gtatcagttt    360
 catcattacc tggctgctgc tgttgtttgg ccaaggagtg aagaccatgc aggttgtaga    420
 gttcttctat gggatggtca ccgccgccga ggtggcctac tacgcctaca tatacagcgt    480
 ggtcagcccc gagcactacc agagagtgag cggctactgc aggagcgtca cgctggccgc    540
 ctacacagca gggtcggtgc tggctcaact cttggtatcc ctggcgaaca tgtcgtactt    600
 ttacctcaac gtcatatcct tg                                             622



      <210> 623
      <211> 934
      <212> DNA
      <213> Homo sapiens


      <400> 623
 tttttttttt ttcacacgca caacttggga atttaatctt cacttttcct cccataaata     60
 tagagtgagg gtgtgatacc agccccagcc cagtctcctt ggggtctgca tctctgcttc    120
 ctggcagcct cttgagtcga cttggggatt tgacgtcagt tgctcagctc cattcctttc    180
 cttctggact tggggaggtc cgggatatgt cggggagtga gtcagtgcag gggactgagg    240
 gggtggttcc cattcttccc tcttagcccc cttcaaccaa tgatccaagt tcaaggagct    300
 catctctgtt tttcagacca tcgagctagt gccttgaagt ctccggaaca gcgcacccag    360
 gaaggggatg ttgcagacat tgcccaggaa gccgaaggcg acagggaaaa agcccttaaa    420
 gaggctgaag aatccgtagg tttccaggaa catgccgagg aggggccagc gtaggagcac    480
 gataaccaca ccccccagga ggaagctggt tcccttgagt ttgtgccgtt ggaagaagaa    540
 ccaaaaggtc ttcctcaggc caatgatgag ggacaggccc gtcaggaaca gcaggtttcc    600
 aaaggccagg agcacggaat caaagtacag gagtgttcca aagaggatga agaagatgcc    660
 gaaaccggtg atccccacac caatcttctg ccattcggtg atggagatca tgccgcactc    720
 agcctggggg gctttccggg tggaagcggg caagtggagc gtggcccaga ggacgcagct    780
 ggtacatggt cacgggaagc tgacccttgg ttaagttgcg aaatgagcct gtggcaaatc    840
 attaactctc cctccagccc ccgctccacc cccgcacacc acgcaggtgc ttctactcgc    900
 cagctccctc ctcccgtttt ccggtagggc aatg                                934



      <210> 624
      <211> 1549
      <212> DNA
      <213> Homo sapiens


      <400> 624
 gacatcatcc catgggacta cgacgtggac ctgggcatct acttggagga cgtgggcaac     60
 tgcgagcagc tgcggggggc agaggccggc tcggtggtgg atgagcgcgg cttcgtatgg    120
 gagaaggcgg tcgagggcga ctttttccgc gtgcagtaca gcgaaagcaa ccacttgcac    180
 gtggacctgt ggcccttcta cccccgcaat ggcgtcatga ccaaggacac gtggctggac    240
 caccggcagg atgtggagtt tcccgagcac ttcctgcagc cgctggtgcc cctgcccttt    300
 gccggcttcg tggcgcaggc gcctaacaac taccgccgct tcctggagct caagttcggg    360
 cccggggtca tcgagaaccc ccagtacccc aacccggcac tgctgagtct gacgggaagc    420
 ggctgaagcc tgataacctc gcctttgttt ttcgggggtc tgtctggatg tggagaagct    480
 ctgtgtgagc ggtgaggggt ggagggatgt cgcggggatg ggaaggggga aactgaccaa    540
 gaaagaaatt ctaaggagag catgagagaa ggctggcatt ggcaggagga gagcaccagg    600
 acgaggatgg gaagcgacct ccagatttat caaatggtca tgcccactgg gagccgtgga    660
 tatgcgtggg gacatcctgg gtcatctcag tcatggaggg agacggggat gtcacgccgt    720
 cccgcagggc ccagcacagc cccagacccg aaaaaagtgt tctgcccaag attccgagag    780
 ccctgcgctc tagggcaggg gcagagtttt ggaaacagtg caggctctgg agccagactg    840
 gcgagattca aatcctggct ctatcgcttc ggagccaggt gggcctgggg gggcgtcgca    900
 gtctctctgt gcctcagttg cttccaggat gcgggaccct tggctgcagg ggttgcttcc    960
 gccactagag ggcgcgccgg tcccgctcct ggtggcccac tgtggctgcc cgggcgacag   1020
 tacgcccagg gcctgtgttc catagccatc tactctcttg agcctttgga cttctctcca   1080
 agcccctgtg ggaggcggac agcagtgacc acctcccctt cttttggact gcgacctcct   1140
 tccctcctgg gagagccctg tgacctgcat gctactctta actgttctat tcaagactga   1200
 atagaagtat ttcagtcttg cagaggagga aatgctcaga gctccgaggt gcggctgtgg   1260
 tcgagaaccg ggtgctgggc cgggcgcggg ggctcacgcc tgtaatccca gcactttggg   1320
 aggccgaggt gggaggatcg cttgagccca ggagtctgag accagcctcg gcaacatgcc   1380
 aagaccccgt ctctattttt aaaaaagaaa aagaaccgac ttctgaatcg cagctccact   1440
 catgactaat acctcattat ttcagctgtc tgcacctaat tccccacttg cacggcagtg   1500
 ttaggacaat aaccatagct cacactcact gagcacctac tgggtacca               1549



      <210> 625
      <211> 1319
      <212> DNA
      <213> Homo sapiens


      <400> 625
 ctgccatcgc ccccaaggat gacctcttct atggcttcct aaaaccttgg ctaggggatg     60
 ggctgctgct cagcaaaggt gacaagtgga gccggcaccg tcgcctgctg acacccgcct    120
 tccactttga catcctgaag ccttacatga agatcttcaa ccagagcgct gacattatgc    180
 atgctaaatg gcggcatctg gcagagggct cagcggtctc ccttgatatg tttgagcata    240
 tcagcctcat gaccctggac agtcttcaga aatgtgtctt cagctacaac agcaactgcc    300
 aagagaagat gagtgattat atctccgcta tcattgaact gagcgctctg tctgtccggc    360
 gccagtatcg cttgcaccac tacctcgact tcatttacta ccgctcggcg gatgggcgga    420
 ggttccggca ggcctgtgac atggtgcacc acttcaccac tgaagtcatc caggaacggc    480
 ggcgggcact gcgtcagcag ggggccgagg cctggcttaa ggccaagcag gggaagacct    540
 tggactttat tgatgtgctg ctcctggcca gggatgaaga tggaaaggaa ctgtcagacg    600
 aggatatccg agccgaagca gacaccttca tgtttgaggg tcacgacaca atgatccagt    660
 gggatctctt ggatgctgtt caatttggca aagtatccgg aataccagga gaaatgccga    720
 gaagagattc aggaagtcat gaaaggccgg gagctggagg agctggagtg ggctcgaatt    780
 cgaattgata gcaacccaac ccaccgggca gacgtgacca caaagcagac aacccacaca    840
 tttctcggta ttacaatgcg gtgtgcgggt tttctcgctc cattccatcg cctggtgacc    900
 gccgtcgtaa caggaaatat aacagcgtcc acagccaaca catttatcaa gattgatacg    960
 gggatagaca atataactgc ggtctaaatc ttccgccggg acaatattgt tattcgccag   1020
 acctaccatc tcctgcagcg aatcaaatcc ctgatcggcg agataatgcg acaacccgct   1080
 tgccatatct tccactatcc gatacccgta ctgcatgatg ccggtggtca cctgtaacgt   1140
 tgctgcgccg agcaataaaa actcagccgc atcctcccag gtttcaatgc cgccgatacc   1200
 gctgattggg aaatcgcgca gttctggatg ggtgcgcatt tgtaaaacca ccggcaggag   1260
 tgataggcca aaaagtgaag gcggaggagt acgattaacc aatagtacat aaagaagtg    1319



      <210> 626
      <211> 3450
      <212> DNA
      <213> Homo sapiens


      <400> 626
 cagggtggtg aactaaaaaa gctggttcct gtgaaccttg ggaaatggtc tcacccctct     60
 gagccctgga gatgacctga tggggcagct aggaggtcca aatggaagga ctgcaaataa    120
 aaggcactgg gaactctcag gggccacaca catgtgagat cttcccaata aaatcagcct    180
 tagctttaaa accaggaaat tgttagcaac aggctctcac cttcctccaa cacccacagc    240
 attgcctatc tccctgtgat agcttgattc taaagataac agcctgcctt tactcagaaa    300
 ccaggactgt gacgtgtttt gcacacattc tcttttcact ttcacagtgt gtgactatgg    360
 catgcaactt atgttctctg tgcctcagtt tactcaagtg ttaaacagga atactcacat    420
 gaggattaca tgagttaaaa tggataaaat ggataaaagt agagagtaaa ttatttaaac    480
 tttatcaaat ccttggtaca tgaccttaat acaattaagt atttgttaaa tacatacatt    540
 ttaaagaaac gtcatcatat ccacacacct atgaggcacc tgcccaggac cacagagcca    600
 atcaatcagg tgatgagtga ttccaggcca gcaggaaacc accgcccact gacacaggga    660
 ctgcaccatc catccttggt ttgcatggtg cctgccatgc ttcctgtatt actgttaaat    720
 acatggggca ggcctttgga ggatcccaat gttttaaaag ggcaatacga atatgattct    780
 aatacataaa aagtatgagg gcagcaagaa tttagttaca aaacccaaaa atcctcaaag    840
 agaagccaca tagcactgtg cagtgttacc actgcctcga gtctggacag ggcacaggtg    900
 accgagacaa gtcttattta actgatttca caagaagggt ccgagtttta ttagacaacc    960
 catgtcaagg tacaaaatga ttaatgacaa tatcagccat attctattag ccaagtgcca   1020
 cctgtcacta tgaaactatc ctgtaggaca tccctgggct ctcagttgct aatgggctgc   1080
 tgaagaaatg aatgtcctca aatcgagacc ctaacacaaa gagattccag agagtggctt   1140
 agaaaaccca gctactctta ccaatgtggg gaaagggtca ggggaatgaa cctctgcagg   1200
 acaatttgaa ttcccaaact gagtaagagc gaaacaaata tgcaggcaag gcaaagcctc   1260
 aggggggctc ctgggtctgg ggcagggggt gggagacagg agaggcaaaa tggcagggac   1320
 ttgacagcag gttcctcttg tctacttctt cctcccgcct ctctccttga gggccaggtg   1380
 gatgactgcg ccattggcca tgttgtagta agccagtgag ttggaatctt tgatgaagat   1440
 accctcatac tgtagcttct gtttccctgc aggcatgcct gtggcttcat gaatcttcac   1500
 cttaatgaca gagacctggt ccgtgagtgg gagggtgaag accagcacct gcccattcag   1560
 tttccattcc gtcttatcct gcatgttggg cacctggact ttgatggaca ctggaccctt   1620
 gtttctgcgc aggaactcct cctctggcat gaggctgtcc tctgtcttca gttttttgga   1680
 ggtgggctca tcttccatgg gaggtggggg atgcacaggg ggcattgggg ctggagctgg   1740
 gacaggtgcc acaggtggag caggcacaaa ggctgttggc acaatcatgg ggggtgggcg   1800
 gggggccata ataggagggg ccgagggagg catgggcacc acgttgattc tgggcgcgtg   1860
 gatgatgggc ggcatggggg cgatcactga gcctgggggc agccggacca cagatgccat   1920
 tgggggccgg ggcatgacgg gtactgcgga gacaactgta gtacgaactg gaggtggcat   1980
 tgtgggtggt cggggcactg aagtgatggg tggagccgag ctggggatgt tggtggctga   2040
 agatggtggc ggtggctgtt gagggatttc attgggcttg ctggggccaa tcttctcttt   2100
 agtgtcatcc tctggcacca ggcctttggc cttgtgaatg gcctcaatct gctcctggag   2160
 ggtgatgttg gcctgggcag cctgctgggt ccgggccatg ctgcctgagt ggccatccca   2220
 ggtcaccttt tcctctggct tctggatctc ctcctcaccg atcttcttac caatggctgt   2280
 ttcctctaca ccgaagatgt cagtacgccg ctcagccaac tgcttcaagc tgctctcaat   2340
 atccagacct ggtgcgtaca cctcatcatc gctctgcttc tcacggatgg agcgatcccg   2400
 ctgctccagc cagcgagggt caagaagtcc aatgcgcatg tgttcctgca ttttgctggc   2460
 ggggatcttc tccccagtaa tgggggacac aagatactca tctggagcag gggctggagg   2520
 caagggcttg gaggctttgg gatcataatc cttgcggaca atgacttggt ctggagttgg   2580
 gggcagaggt ggaggcatgg gtgtctctgg gggtgggggc actttctgcc cttcttcttc   2640
 atcatctgaa ccctcatcca tatcttgtac ttgggtgtcc tggtccagct gggaaggagg   2700
 ctcctccgcc ttctcctgtt tgtcatcctc ctcatcagac tcgacctcca tctcaacttc   2760
 ctcactctcc ccaaactttt catagcgctc ctgaatgagg attcgggccc ccagctcctc   2820
 tggcgtggtg gggggaggga agttcccttg ctcattgggt tggaagtcca ctgtttccac   2880
 caccacaaaa tcatgccagt cgatctgagc ataggccacc cgctccttct ccttctcctc   2940
 ttcttccttc ttcctctcac gttcctggaa tttggcccat tccactcggt aacacacctg   3000
 atccaaaact tctcgggggt tttcagcctc tttcttgagc tttgaaaata aacctttggg   3060
 tggaatcaag atcttggtgt actgttccac tagcttcgtg aagtagttga agaggctgtg   3120
 ctgtgggcgg agaaagtcaa actggtagtt gcgctgctct ttctgcatca gctgggtcag   3180
 aaactggcgc ccattcctgg ccacaaattg agccgtcagc ttcaccacat ccaagtcgaa   3240
 ggctgagata gagggaggat cagcaatgaa ctcaaactca ggaggaggct ctttgggcac   3300
 gatggtctct tggattactt gggcttggac cttctggggc agctgctgct gggtggtctg   3360
 ctgctgctgc tgcatgacct tggggatggc ggcggacggc tcctgagcct tcccttcctt   3420
 gaactcgctg accttgtggc ggtagtaggc                                    3450



      <210> 627
      <211> 728
      <212> DNA
      <213> Homo sapiens


      <400> 627
 gccggccacc ccggaccgag gcaggacctc accccgcgcg tgttccccgg gcgcccctct     60
 gcgaacccca ggcccttccc aggtttgcgc gcgggggcca tccagaccct gcggagagcg    120
 aggcccggag cgtcgccgag gtttgagggc gccggagacc gagggcctgg cggccgaagg    180
 aaccgcccca agaagagcct ctggcccggg ggctgctgga acatgtgcgg ggggacacag    240
 tttgtttgac agttgccaga ctatgtttac gcttctggtt ctactcagcc aactgcccac    300
 agttaccctg gggtttcctc attgcgcaag aggtccaaag gcttctaagc atgcgggaga    360
 agaagtgttt acatcaaaag aagaagcaaa ctttttcata catagacgcc ttctgtataa    420
 tagatttgat ctggagctct tcactcccgg caacctagaa agagagtgca atgaagaact    480
 ttgcaattat gaggaagcca gagagatttt tgtggatgaa gataaaacga ttgcattttg    540
 gcaggaatat tcagctaaag gaccaaccac aaaatcagat ggcaacagag agaaaataga    600
 tgttatgggc cttctgactg gattaattgc tgctggagta tttttggtta tttttggatt    660
 acttggctac tatctttgta tcactaagtg taataggcta caacatccat gctcttcagc    720
 cgtctatg                                                             728



      <210> 628
      <211> 1571
      <212> DNA
      <213> Homo sapiens


      <400> 628
 tttttttttt ttcaaactgc tttactatac tttattgata taaatacagc aaatctcaat     60
 aagcaccagc taccatttta ccactacaca agagaaacaa agtcaaaaga attatatatt    120
 aatgcaaaga gtaaacacag aatgctttca cttccactat agtcctctat aacaaaacat    180
 cctacatact ttgtacaatt tgcttataat tggttaaata tttgatatga agcaaggttg    240
 atttttaatc aaacttctat ttctcagtgg aaaatgctct cttcatcaga ggtggttgag    300
 ttttcccgac atcaaacatc atttccaaag gtgggttatt gagagaacac caatcaggta    360
 tacggcccgt ctgattataa tattcctttg aaacagaacg gctcccaagt atatcttgta    420
 atgctccaaa aatagcccct cccaaccagg ccacacaatt agcttttgca ggtggagtat    480
 gaattcgaaa tgtcttagtg ccaagtgctt ttttatattt tggtttttct accaaatacc    540
 ttatttctgc aagcaatctg tggagaaatc ctggcaacat agaagtgcca cctatgacta    600
 ccaaattctc tgctagttgc ttcctggtgt ctatcggaca ctgtataagg gaatccaata    660
 ttaaagtggc aactgattgc tcttcattat cttgttcaaa aagaatttcc acaactgaat    720
 ctctgattga tccaaggata tgtaaaatct tctctccatc taatggatag tcaacatttg    780
 ggggtgggga gggacgctca ttattcccat caatattaaa ttttgctgct tggattttta    840
 gtcctcgctt cagatcactt acaaagcaag tacgcgcttt aatgtcctct aagacacctt    900
 ccggaactga acccatcact gagggaaggc tctgttcttt agcaacactt gtgtcaacag    960
 tacattgttc caatagttga gtttccaact ctttgtgaag agcttttcct cctaggggta   1020
 gtgctcccca acaatttaga actgggattc cttcatatat gggtaacacc aggctttccc   1080
 tatatccaca atctaggacc atggcagaat taattccaag cgtcagaaga gccattagat   1140
 gacttggagc aagcaagaca gatggaacct caaaatattt gaaaagaaca cgagtgagtg   1200
 tctctctgaa gtgagaagga cataataccg attcgataat cacaactcgg cggtctctgg   1260
 gattcaccaa tagatgcctg aaatatagta tgtggatgaa ttcctttagg taggaatata   1320
 attcttctgt attgatatta tactgaacaa ctctgacagg cttaggcatc ccagctcttt   1380
 ttatcacact aggaattata catcttggac cagtttctcc agcaaatcca cacttggtaa   1440
 aggcctctcc caggtcgatc acgaccgccg tcttctcccc gccgctcccc aggccctcgt   1500
 agagcggcat ggtagtaagg cagactgaga gaagagggtc gcagtctccg cggccaacaa   1560
 gtctcacgaa a                                                        1571



      <210> 629
      <211> 1960
      <212> DNA
      <213> Homo sapiens


      <400> 629
 ttttgacttt gcaggatgtg ctttatttta agtcagccct gaacccaaac tacacaggat     60
 caatttttga catattctag tccattcaat gattcttctc agaaactgta tcttaatatg    120
 gaatgaaaac tacatttcaa tcataaattt ttcatgctac attgttattt aatgaagagg    180
 ttgtattacc aataataata atttaagaaa aggccatttt tatttcccca agctcaatat    240
 acatatttct ttcataatta tgaacttaaa aaaacccgtc tcagatgtaa aaatgtgaat    300
 tggaatatgt aaactctttg atatacctga aaaacaggaa ggaaaatgtc acatactggg    360
 aaaacccctt ccctttaatc atggaaatgg gaaaaagccc gtttaaggaa agggaaggcc    420
 aaaaaaccgt tcctgacctc agtttttaaa aaggttccaa gtttttttgg gccccctggg    480
 gtggtctttt tacttttttg cccccagttt gtttgcccag gagaccccag ccctccagaa    540
 tggtttccct ccttgaaagt ggtccctggt gggcccaaac caaaccgggg gtccccccct    600
 ttgttttgct cccttttttt ttttttcctg agaagtcact ggtgtttaat ggaaaggtat    660
 cctattagtc cttggttaag ataaggcagt aagagtatca ctaatactat gtttttgctt    720
 agaatgaggc tgatcctttc cactggcgtc ttcacgggca attagttccc tctcttttgc    780
 tcctagaaac acaggtagga gctgtctgcc ccctattgct gttgcatttt cctgagtgtg    840
 ttgaaggctc atctagtctc atcacaagca gcttccccag tggggatggg agcgctgtat    900
 attgcattgt agcatctctc caaggaaagt gcacggggcc ccaacagggg aaaacaccag    960
 gcatctttct ttctgactcc tcttctgttt ctcttagggg acggggccca taaatgattc   1020
 cttcacatga tcaatcagaa tgcgagacac tgttgactaa aacataaagc aagtagccct   1080
 gatttcagag aaatggagtt acaaataaca ttttcaacag tgccttaact tgcaaggtag   1140
 cttttactgc agaaggatat cagctccttt tgtctaccta tcagaagaga aacaaaccat   1200
 ttccgtcgaa ctagaaatgc ttagctctta tgagaatatt gtgcttttaa aaaaaattca   1260
 aatgttaaca ttatttgcag tctgtgttct aaggtttcaa tttgtttttt ctctagtcca   1320
 tttgatcatt gtctctggtg agcgatatag gaatattaat ttggcataga gatcttcttc   1380
 tagctccagt tctcctgtct ctcgaactaa aaaaatatct gtgcacaact tcaaaattcg   1440
 atcccacatt tggaagctcc ttcaaacatg atggagtgag aaatcccact gaagaattca   1500
 cggacaaatt tcccaatcac aaggacaact gaagcatata atcccataat accatagcca   1560
 gcccaggaac cccagacttg ggggactgac tttgtcattg aagaccacca gttccagggc   1620
 ctgagagttc ggattgtata ttctgtttcc agtcaggttg agaacccacc actcactgtt   1680
 atatttagtt gtattgtctc tggacaaaat gatggtaata tccatgaaat tattttcaga   1740
 taaaagttgc tttataggtt ttgagttaga atcactaggt gctttcacat aatatggata   1800
 aatcttttct atggtcactg gtgtttttga actttctgtg ctgttgcctg ctatcatttt   1860
 agcgatattc tttcgagtaa tatttttaag aggaaaagaa agcttatctg ttgctatttc   1920
 cgattttgca cccagactta agtttctctg aatactccat                         1960



      <210> 630
      <211> 542
      <212> DNA
      <213> Homo sapiens


      <400> 630
 cagcatccac atagtctaca cagagctccc cttgctgccc agacaagctg aaggaccaca     60
 ggaactcaga tacacaggaa acagttgttt catgtgtcgg actcctttcc attgctcttt    120
 ccaatgtggt aatgcagcta aactaagaga aaagccatgg agacttcagc atcctcctcc    180
 cagcctcagg acaacagtca agtccacaga gaaacagaag atgtagacta tggagagaca    240
 gatttccaca agcaagatgg gaaggctgga ctcttttccc aagaacaata tgagagaaac    300
 aagtcttctt cctcctcctc ctcttcctcc tcatcctcct catcttcttc atcctcctcc    360
 tcctcagaga gcaatgatga ggaccagcaa cccagagcaa ccggaaaaca tcgacggagc    420
 ctgggggctg gataccccca cgggaacggc tcacccggtc ctgggcatgg ggagcctgac    480
 gttttgaagg atgagcttca actctatgga gatgctcctg gagaggtggt accctctggg    540
 ga                                                                   542



      <210> 631
      <211> 349
      <212> DNA
      <213> Homo sapiens


      <400> 631
 gccggcggga ggccgagcgg ggctcgacag agcaggatcg agatgaccac agccacccct     60
 ctgggggata ccaccttctt ctcactgaac atgaccacca ggggagaaga cttcctgtat    120
 aagagttctg gagccattgt tgctgccgtt gtggtggttg tcatcatcat cttcaccgtg    180
 gttctgatcc tgctgaagat gtacaacagg aaaatgagga cgaggcggga actagagccc    240
 aagggcccca agccaaccgc cccttctgcc gtgggcccaa acagcaacgg cagccaacac    300
 ccagcaactg tgaccttcag tcctgttgac gtccacgtgg agacacgat                349



      <210> 632
      <211> 10120
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(10120)
      <223> n = a,t,c or g


      <400> 632
 tttagaatgg tgtcaatgct ggttttgtgg aatagaaagc gggggaaagg tggggaaaag     60
 attgagaaat cggatggttg ccgtgtctgt gtggaaagaa gtagacatgg gagacttttc    120
 attttgttct gtactaagaa aaattcttct gccttgggat cctgttgatc tgtgacctta    180
 cccccaaccc tgtgctctct gaaacatgtg ctgtgtccac tcagggttaa atggattaag    240
 ggcggtgcaa gatgtgcttt gttaaacaga tgcttgaagg cagcatgctc gttaagagtc    300
 atcaccactc cctaatctca agtacccagg gacacaaaca ctgcggaagg ccgcagggtc    360
 ctctgcctag gaaaaccaga gacctttgtt cacttgttta tctgctgacc ttccctccac    420
 tattgtccta tgaccctgcc aaatccccct ctgtgagaaa cacccaaaaa ttatcaataa    480
 aaaaataaat ttaaaaaaaa aaaaaaaaaa aaaagaacct ggcagggcac gcaacccagt    540
 accacttacc tttgggccta aaccccactt ccgagggtaa gtgtctctct ccatgatcac    600
 tctcttgatc ttggctacta taccatggtc gcaggtagag atgaccgctg tggtcattaa    660
 tgcaatagct acaggcattg aataaagaaa agaattattt gaagggtgaa agaattgata    720
 attgatgagc cccaattcta ctgttgtatg ccactttaaa acttttaaaa ctctgagcta    780
 ctactttaat tggggttacc tttgctcagg atgtgcatat ggaggaaata ctccattatg    840
 agaaggaggc ctttgaaatg acgttaaact tctgaagtta aaaaacacct aaccaaagca    900
 cctaacgata cacataacag gcttgcagct caagacgtct ataagaacgg catgcacact    960
 ccctttgggg ccacagaacc tttgaagttt taaggattcc ttttctgctg ctgtccataa   1020
 gccgtggctg ccttgcctgc tcacagagct aaggaatcct gatgacatgc ttacttctgg   1080
 tacaaattag acccattaaa tgaatagctc taaggttcat tcactaagag ggtgcgcaga   1140
 gcatttaaag tcttaagaga caatccaaca gtagctaagc tttcacaagt taaaaaacac   1200
 tggtacttta catggaacca caaaagactc aaaatagcca aagctatcct aagcaaaaag   1260
 aacaaacctg gaggaatcac attacctgac ttcaaattat agtatagagc tacagtatcc   1320
 aaaacagtat ggtactggca taaaaacagg cacataaacc aatggaacag aataaggaac   1380
 ccagaagcaa atgcacacac ctacatttaa ctcatttttg acaaaggtgc caagaacata   1440
 cactgggtaa aaaccagtct cttcaataaa tggtgctggg aaaactagat atccatatgc   1500
 ataagaatgg gagaaaatat ccgcaaacta cccatctgac aagggattaa taaccagaat   1560
 atataaggaa ctcagcacta taggaaaaaa aatctaataa tctgatcaaa aaacaggcaa   1620
 aagatttgaa cagacacttc tcaaaagaag acaaataaat ggcaaacagg catatgaaaa   1680
 agtgctcaat gctgatcacg agagaaatgc aaatcaaaac tacaatgaaa tatcatttca   1740
 ctccagttaa aatggtttat atccaaaagg caggcaatga caagtgctgg caaggatgtg   1800
 gagaaaaggg aacctttgta cattgttgat gggaatgtaa attagtataa ccactatgaa   1860
 gaacagtttg gaggttcctc gaaaaactaa attgagctac cataggatcc agcaatccca   1920
 ctgctgggta tataccccaa ataaaggaaa tcagtgttat caaagagatc acagtagcca   1980
 agatttggaa gcaaccgaag tgcccatcga cagataaatg gataaagaaa atgtggtaca   2040
 tatacacgat ggattactat tcagccttaa aaaagaatga gatcctgtca tttccaacaa   2100
 catggatgga actgaagatc gttatattaa gtgtaatcgg ccagtcacag aaagacaaac   2160
 attgcatgtt ctcacttatt tgtgggagct aagaatcgaa acaattgaac tcatggacag   2220
 agaagagtaa aagaatggtt accagagact gggagggtag tggggggctg gcagggaggt   2280
 agggatggtt aatgggtaca aaaaaaaaaa aaatcaggcc cggcatggtg gctcacacct   2340
 gtaatcccag cactttggga gggcagatca cctgaggtca gaagttcgag accagcctga   2400
 ccaacatgac aaaaccctgt ctctactaaa aatacaaaaa attagccagg tgtcatggtg   2460
 tgcacctgta atcctagcta ctcggaaggc tgaggcacga gaatcgcttg aacctgggaa   2520
 gcagaagttg cagtgagccg aggtcacgtc tctgcactgc agtctgggtg aaaagagcaa   2580
 gactgtctca aaaaaaaaaa aaaaaaaaaa acaccaccac caaaaaacca aaagaatgaa   2640
 caagaagagt gagactattt aatagcacaa cggggtgact ataatcaata ataacttaag   2700
 tgtatatttt aaaataacta aggtgataaa taactaacag taaaatagga ttgtttgtaa   2760
 cacaaaggat aaatgcttaa gatggatgcc ccattctcca tgatgtgatt attatgtatt   2820
 gcatgcctgt atcaaaacat ctcatgaacc ccataaatat atacacctag tatgtaacca   2880
 caaacattta gaatttggga aataaacatc ccctctnacc catgcagatt gcttctcctt   2940
 tggtggtgat aaccacaatc tcctgattga cctcaatgcc gtcctcatat cgaataacac   3000
 ctggaagcat aatcttggcc ccatagcaga tggcatttac ctgcagagat ggcaccaagt   3060
 gtaaggggcc cagctgctgc cctccacccc actcccacac cagagtaaag gaggacaaca   3120
 agggagtggg gcctgacacc aggaaacagg gatgacactt atagcccact agctgcaagg   3180
 ggcatgagtg gtactcagaa gagccacctc actgtgctat aggtaccact ctccgcacat   3240
 tacacacgac tcaaaagtag taaagaagac tttcaggttt tcaggttcta gagactcaca   3300
 agtattttct tttttttttt ttttttttta attttcaggc agaacctccc tctgttgtcc   3360
 agggtggagt gcagtggcac attctcggct cactgcaacc tccatctccc aagttcaagt   3420
 gattctcagt ctcccaagga gctgggatta caggcacgtg ccaccacgcc cagctaattt   3480
 ttgtattttt aatagagaca gggtttcacc atattgccca ggctggtctc aaactcctga   3540
 gctcaagcaa tttgcctggc ccggcctccc aaagcgctgg gattatgggt gtgagccacc   3600
 gcacgtggtc catattttca tttgaaacat aaaaatagcc ttggcattcc ttaattactc   3660
 ctctctcctc cttatgagga gaaagaacag atttactgga gatccaggca ataacaggct   3720
 cttaaagaac ttgagaacaa gattactgag ccctgttgaa ccaatcacac aaaagtcttg   3780
 gtgcagaatt tataggtcag tgggtacaag ttaaggctac ctctccagag gttcaatggt   3840
 acccaatgca cccatctgcc tcataccatc tccactcacc tagacctctt ttgatcacat   3900
 tctcccctcc ctttacattc acccagaagc caatggtttg ataaggagag gacatcacat   3960
 ttatgttgtc cactgttttg tgactgagtt ttttcaacta ttatggtgcc atctttcagt   4020
 atttattaca gcctatacac atacaaaaaa tgtgaacatc tatacaagat ttgaatataa   4080
 ataattacca actacaaaca ttttaaatat ccagaaattt ttatccctca agttagagaa   4140
 aaagacaatg ttttaattta taaaaggcca actctctgat catcataaaa acacagctca   4200
 cagccttgat ctcctgggct caagctggtc tcaaactcct tcctggactc aagtgatcct   4260
 cttgcctcag cctgccaaag tgctaggatt ataggcatca gccactgtgc ctggcctaat   4320
 gtgccttatt tttaagtatg cctaccatta aacttttact ttaaattaat atacttggtt   4380
 tggacttgaa aaaaataaaa taaaacccaa ggaaaacaat aaaaagagca agcgtcatct   4440
 ttggagtacg ttctttccaa atataaactc ctaacccgga acttactgca ctgtctttca   4500
 taaccagccg tttatgagat gtcaacagct tttccaaagg gtaaacaact cgccgtaggt   4560
 aactctcatc cttgtggtta tcatacagcc actgagcatc aagcacatca tgcattgtca   4620
 ccatgtggtc ctgaaaagca gccatgtatg aaaataattc agtttatttg tatctcagcc   4680
 catcagaccc caaacttcct aaaactgaat gtcacttgtt tactagtcca agctcattat   4740
 gttttcagcc tcttcagtcc tggctcttcc aggcatcttt tttttttttt tttttttttt   4800
 ttgagacgga gtctcgctct gtcgcccagg tgggactgcg gactgcagtg gcgcaatctc   4860
 ggctcactgc aagctccgct tcccgggttc acgccattct cctgcctcag cctcccgagt   4920
 agctgggact acaggcgccc gccaccgcgc ccggctaatt ttttttgtat ttttagtaga   4980
 gacggggttt caccttgtta gccaggatgg tctcgatctc ctgacctcat gatccacccg   5040
 cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgccctc ttccaggcat   5100
 ctttaaccgt tgaagtatta gaccccaagc aggcattttt gtaggctggg aggcaaatga   5160
 atagaataat actttctacc caatcatctc ccttagccca ttttaatgtc ccaaagttta   5220
 attaacagaa cagggaagct gccctggact gaactcaaca ctttggaaag catctttccc   5280
 acgacatgaa gcaagtggag tgccatcaaa ggctggcaga tggtaagaac cagctctaaa   5340
 acttctagcc ccgtaacaca taccttttca ctcatgactc cagaacgaac cctccgaagc   5400
 tcctgcatct gaccaccaac tcccaataac aaaccaaggt gcacacataa tgtccgactg   5460
 taggtgtcag cctcacaact cacccaaaag attcctaaga tacacacaca caaaagaaaa   5520
 gcagcaccta ctgtaaatac atcactggtt gagaaatgca gttatccttc atctgagcca   5580
 ccaagactag aggtgacaga cacacttctt aaaatataag catttgctgt aaagatctgt   5640
 aattctggcc aggcacggtg gctcacgcct gtaattccag cactttggga ggcagaggcg   5700
 ggtggatcac gacgtcagga ggtcaagacc atcctggcta acatggtgaa accccgtctc   5760
 tactaaatgt acaaaaaatt agccgggcat gatggcgggc gcctatagtc ccagctactt   5820
 gggaggctga ggcaggaaaa tggtgtgaac ccgggagaca gagtttgcag tgagccgaga   5880
 tcatgccacc gcactccagc ctgggcgaca gagcgagact ccgtctcaaa aaaaaaaaaa   5940
 aaaaaaaaaa gatctgtaat tctgatatta gcagaatttt taacacttaa gttgcaggta   6000
 tattcagcat ggtatgtttc atggatggga ggaaaattgg cattgtctta aatttacttc   6060
 tgacaacaga aacttctaag cagtcaaaat tgcagcaaat aaaaaacaca tgcaaaacat   6120
 actttggtga aaacacttac ctttgaacaa agcaccgaac tacacaaatg cagaatgaaa   6180
 acatttcaac tccagcagaa gcagtcatca taaaaggtgt aaaagccatc tcactttact   6240
 aggcactgtt cactttttca acaaaagata acaaaaacta tcgcccacag acaatatccc   6300
 agctgtaggg caggttttag aaagtcttca acttcaaggg catctacttt taataagaga   6360
 acagaatcct gaagaatgtg ttcataccca ctcacaggcc taatgactca cctaatcttc   6420
 tttcaggatc gtattcaatc attttgctct cgtagatggt cctcactcgg agctgcctct   6480
 ttactgcagc aataagtggg ggtcgctgga ataaggcacc tgtcagagtt tctagggcct   6540
 aagaacaaac acaaatgaaa acaaacacct catcagaatg tacatgtgca gtcactggtc   6600
 caggctggct gcagcagccg actgaaaagg ggacaaaagg agtcagtcag gacagctaac   6660
 ccatctccag atgtttaggg gctcagagat ccaagtcaac aaagggtgtc ctccctacaa   6720
 ttgcagactt accctagaaa gctgggtccc cccttcaata gcattgtgca gccggacaat   6780
 ccccacatac tctttgcctg aaaaatgaca aaagagtagt caggtgtggc cactgagttt   6840
 tctgttttcc atatttctta tatgctcagt cactcccatt ttgcacagca ggaaaagcgg   6900
 cagtttgacc ttgtgtttct ataaaatttg cattaagaga gatttcatgg tgatgatgtg   6960
 ggaaagaatg aagacacttt ctcactggga attcaatgta ctaacaggga cagttgggag   7020
 tactcagtgt agaagctgcg tggaaaaagc cttgcaagat aagcaggctt ttctcagata   7080
 aaaatgaacg aaggatactt taggcagaag cggtagcaca gagtgagaag cctggagtga   7140
 caagctgaga gctgaacccg gacaaatgga tccagtcagc ttgatgaata catgcttagt   7200
 atgtggaatt ccaaaaagcg cggaccacca agatctggca ggggacagaa cgtacacaga   7260
 aaccaaaaca atatccttgc tttaggattt ttttttttct taatgaagaa atagtttcca   7320
 gcagacaaaa catagaaggg aaatacagaa agcttttcac tctagccagt ccttccctcc   7380
 ctctcccaca tacctgcact ctgttgtgac ttcaccaagc gagtggctcg ttctatgcac   7440
 acgattaaac aaccagtcac cttgggatcc agagtaccac tgtgccctgt cttctccacc   7500
 cgaagtatcc gtcgaatcca ggctaccacc tcatgggaag aggggttaga gggcttgtca   7560
 agattaatga aacctgtcct ggaatggaaa aaaaaaaaat taatgtatca cccactctta   7620
 atgctccagt gaaacaacaa atctgaaaag ttaaaaagaa aaataattca ctgcgggtac   7680
 aggttatata ttcaagacaa agctattctg gcatgccact gccttcctga atagctgatg   7740
 tgaaagcatt ttcaaaagaa agtaagtttg cacagtgcct cctcccaaca cttacctgat   7800
 atagtcccca atctctctct tcagaggatt ttaaccacat gcaagaggtg tatagtgtgt   7860
 tgtccttaca ttcagcttat caaaattcta caaagcaacg acacaacaca aaacaaaata   7920
 ccatgtcgtg agcacatgta aaaaaagagt cagtaccact atgtggccca caaactggca   7980
 taggtctgca agatggacta agtacaaaaa ctgagaactg ttgacaaact cagcaattta   8040
 acattgtggg gacatgtgtt ctacaacagt gttgagtgca ctgccaattt tttaaaaact   8100
 tggttctcat ttcagatacc ttaaggaatc ctgctttaaa ctgtatcagt gggcacttcc   8160
 caaagtcaag gatgccagca gtaagcattc tcaatcaatt gtttaacact tggaaataac   8220
 gtaaaagcag gcattcatct gatgcacgat tttaaccaca tacctttagc aaaaggggcc   8280
 actgagacgt gtccaactta gcaactttgg attcaggttt gataagaaat tcttcagcgt   8340
 gttgtatttc cttcgacagg acagaaatat aacctattaa acttcccacc cgattttgaa   8400
 caattccatt actgccatgg aaatgtatgc cttttaaaca gaaaacaagg cttcctatgc   8460
 cttttcactg ggacctccaa gggaaagaga gagaagaaat gaaccaggag tacagagggg   8520
 aagtgaaatg tcactaagat gggtccaaac atttaaagag aaagggggat ggcgggtctg   8580
 tgggtggcat aaggaagaca aattcagaga cagcagttgg taaggccagc accatttagt   8640
 aagctatgcc tgaaggacac ttggactgtc tggggctgtg tcatttcagt gctttttcga   8700
 atctacacaa tgactaccaa tgctggccca ttccttggaa acctttaaaa acacttcttt   8760
 cctttagttt gttatttaag taaactttct ttttagtcaa agtgaagtca aacacattac   8820
 tactcacggc tacatcttct tctggcaatg acttccgctc ctttttcttc ttatgtttct   8880
 ttggcaaaat aattactaaa aaaacaaaca caggatttgg gaattttccc caagaataaa   8940
 tgaaacaagg gtttaaaata aagaccgaaa ttagggcagg taggaaatgg attttaggtc   9000
 tacaattaca gtcacatgcc acataatgtt ttgcaagtac agactgcgta tgtgatggtg   9060
 gcccccataa gattataaca gagctgaaaa attcctatct cctagtgatg tcttgatgat   9120
 cctgaccctg tgtaggtcaa ggctactgtg tgtgctgtgt ttgtgtctta gttaacaaaa   9180
 aaaaattttt taagaaaaaa attaaaaaat tttaaaatag aaaacttata aataaggaga   9240
 taagcagaga aaatatttac gtacagctaa ataatgtgtt tgttttaagc taagtattat   9300
 tacaacagtc gaagtaaaaa gtttataaag ttacagtaag ctaaggttga tttattctga   9360
 agaaaaatat atttttataa atttagtgta gcctaggtgt acagattata aagtctccag   9420
 tagtgtaatg tctgaggcct tcacattcag tcaccgactc aaccagggca acttccagct   9480
 cagcaagctc cattcatggt aagtgccctc ctcttcgggt gcaccactta taaccttgtg   9540
 tactatatat atataatata catacatata atacatacat atataatata catatataca   9600
 cacacatatt tatatatata taattttttt tttttgagac ggtcacactc tttccccagg   9660
 ctggagtgca gtggcagaaa ctcggctcac tgcaacctcc ttctccaggt tcaagcaatt   9720
 ctcctgcctc agcctcccga gtagctggga ttacaggcgt ataccaccac gcccacctaa   9780
 attttttgta tttttagtag agacggggtt tcaccatgtt ggccaggctg gtcttgaact   9840
 cctgaccgca ggtgatccgc cagcctgggc tgggatcaca ggcctgagcc accgcgcccg   9900
 gccctgtgct atatttttac tgnccttttt ctgcttagac atgtttaagt acacaaactc   9960
 tcgacgctgt gtcccaactg nctacagcat tccgcacaat accatgctgt caggtttgaa  10020
 gcctaggagc catacgctac accatataca gctaggtgtg tagtagccta tgccacctag  10080
 gtttgtgtaa gagccctctg atgttcacac aatgatgaaa                        10120



      <210> 633
      <211> 10120
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(10120)
      <223> n = a,t,c or g


      <400> 633
 tttagaatgg tgtcaatgct ggttttgtgg aatagaaagc gggggaaagg tggggaaaag     60
 attgagaaat cggatggttg ccgtgtctgt gtggaaagaa gtagacatgg gagacttttc    120
 attttgttct gtactaagaa aaattcttct gccttgggat cctgttgatc tgtgacctta    180
 cccccaaccc tgtgctctct gaaacatgtg ctgtgtccac tcagggttaa atggattaag    240
 ggcggtgcaa gatgtgcttt gttaaacaga tgcttgaagg cagcatgctc gttaagagtc    300
 atcaccactc cctaatctca agtacccagg gacacaaaca ctgcggaagg ccgcagggtc    360
 ctctgcctag gaaaaccaga gacctttgtt cacttgttta tctgctgacc ttccctccac    420
 tattgtccta tgaccctgcc aaatccccct ctgtgagaaa cacccaaaaa ttatcaataa    480
 aaaaataaat ttaaaaaaaa aaaaaaaaaa aaaagaacct ggcagggcac gcaacccagt    540
 accacttacc tttgggccta aaccccactt ccgagggtaa gtgtctctct ccatgatcac    600
 tctcttgatc ttggctacta taccatggtc gcaggtagag atgaccgctg tggtcattaa    660
 tgcaatagct acaggcattg aataaagaaa agaattattt gaagggtgaa agaattgata    720
 attgatgagc cccaattcta ctgttgtatg ccactttaaa acttttaaaa ctctgagcta    780
 ctactttaat tggggttacc tttgctcagg atgtgcatat ggaggaaata ctccattatg    840
 agaaggaggc ctttgaaatg acgttaaact tctgaagtta aaaaacacct aaccaaagca    900
 cctaacgata cacataacag gcttgcagct caagacgtct ataagaacgg catgcacact    960
 ccctttgggg ccacagaacc tttgaagttt taaggattcc ttttctgctg ctgtccataa   1020
 gccgtggctg ccttgcctgc tcacagagct aaggaatcct gatgacatgc ttacttctgg   1080
 tacaaattag acccattaaa tgaatagctc taaggttcat tcactaagag ggtgcgcaga   1140
 gcatttaaag tcttaagaga caatccaaca gtagctaagc tttcacaagt taaaaaacac   1200
 tggtacttta catggaacca caaaagactc aaaatagcca aagctatcct aagcaaaaag   1260
 aacaaacctg gaggaatcac attacctgac ttcaaattat agtatagagc tacagtatcc   1320
 aaaacagtat ggtactggca taaaaacagg cacataaacc aatggaacag aataaggaac   1380
 ccagaagcaa atgcacacac ctacatttaa ctcatttttg acaaaggtgc caagaacata   1440
 cactgggtaa aaaccagtct cttcaataaa tggtgctggg aaaactagat atccatatgc   1500
 ataagaatgg gagaaaatat ccgcaaacta cccatctgac aagggattaa taaccagaat   1560
 atataaggaa ctcagcacta taggaaaaaa aatctaataa tctgatcaaa aaacaggcaa   1620
 aagatttgaa cagacacttc tcaaaagaag acaaataaat ggcaaacagg catatgaaaa   1680
 agtgctcaat gctgatcacg agagaaatgc aaatcaaaac tacaatgaaa tatcatttca   1740
 ctccagttaa aatggtttat atccaaaagg caggcaatga caagtgctgg caaggatgtg   1800
 gagaaaaggg aacctttgta cattgttgat gggaatgtaa attagtataa ccactatgaa   1860
 gaacagtttg gaggttcctc gaaaaactaa attgagctac cataggatcc agcaatccca   1920
 ctgctgggta tataccccaa ataaaggaaa tcagtgttat caaagagatc acagtagcca   1980
 agatttggaa gcaaccgaag tgcccatcga cagataaatg gataaagaaa atgtggtaca   2040
 tatacacgat ggattactat tcagccttaa aaaagaatga gatcctgtca tttccaacaa   2100
 catggatgga actgaagatc gttatattaa gtgtaatcgg ccagtcacag aaagacaaac   2160
 attgcatgtt ctcacttatt tgtgggagct aagaatcgaa acaattgaac tcatggacag   2220
 agaagagtaa aagaatggtt accagagact gggagggtag tggggggctg gcagggaggt   2280
 agggatggtt aatgggtaca aaaaaaaaaa aaatcaggcc cggcatggtg gctcacacct   2340
 gtaatcccag cactttggga gggcagatca cctgaggtca gaagttcgag accagcctga   2400
 ccaacatgac aaaaccctgt ctctactaaa aatacaaaaa attagccagg tgtcatggtg   2460
 tgcacctgta atcctagcta ctcggaaggc tgaggcacga gaatcgcttg aacctgggaa   2520
 gcagaagttg cagtgagccg aggtcacgtc tctgcactgc agtctgggtg aaaagagcaa   2580
 gactgtctca aaaaaaaaaa aaaaaaaaaa acaccaccac caaaaaacca aaagaatgaa   2640
 caagaagagt gagactattt aatagcacaa cggggtgact ataatcaata ataacttaag   2700
 tgtatatttt aaaataacta aggtgataaa taactaacag taaaatagga ttgtttgtaa   2760
 cacaaaggat aaatgcttaa gatggatgcc ccattctcca tgatgtgatt attatgtatt   2820
 gcatgcctgt atcaaaacat ctcatgaacc ccataaatat atacacctag tatgtaacca   2880
 caaacattta gaatttggga aataaacatc ccctctnacc catgcagatt gcttctcctt   2940
 tggtggtgat aaccacaatc tcctgattga cctcaatgcc gtcctcatat cgaataacac   3000
 ctggaagcat aatcttggcc ccatagcaga tggcatttac ctgcagagat ggcaccaagt   3060
 gtaaggggcc cagctgctgc cctccacccc actcccacac cagagtaaag gaggacaaca   3120
 agggagtggg gcctgacacc aggaaacagg gatgacactt atagcccact agctgcaagg   3180
 ggcatgagtg gtactcagaa gagccacctc actgtgctat aggtaccact ctccgcacat   3240
 tacacacgac tcaaaagtag taaagaagac tttcaggttt tcaggttcta gagactcaca   3300
 agtattttct tttttttttt ttttttttta attttcaggc agaacctccc tctgttgtcc   3360
 agggtggagt gcagtggcac attctcggct cactgcaacc tccatctccc aagttcaagt   3420
 gattctcagt ctcccaagga gctgggatta caggcacgtg ccaccacgcc cagctaattt   3480
 ttgtattttt aatagagaca gggtttcacc atattgccca ggctggtctc aaactcctga   3540
 gctcaagcaa tttgcctggc ccggcctccc aaagcgctgg gattatgggt gtgagccacc   3600
 gcacgtggtc catattttca tttgaaacat aaaaatagcc ttggcattcc ttaattactc   3660
 ctctctcctc cttatgagga gaaagaacag atttactgga gatccaggca ataacaggct   3720
 cttaaagaac ttgagaacaa gattactgag ccctgttgaa ccaatcacac aaaagtcttg   3780
 gtgcagaatt tataggtcag tgggtacaag ttaaggctac ctctccagag gttcaatggt   3840
 acccaatgca cccatctgcc tcataccatc tccactcacc tagacctctt ttgatcacat   3900
 tctcccctcc ctttacattc acccagaagc caatggtttg ataaggagag gacatcacat   3960
 ttatgttgtc cactgttttg tgactgagtt ttttcaacta ttatggtgcc atctttcagt   4020
 atttattaca gcctatacac atacaaaaaa tgtgaacatc tatacaagat ttgaatataa   4080
 ataattacca actacaaaca ttttaaatat ccagaaattt ttatccctca agttagagaa   4140
 aaagacaatg ttttaattta taaaaggcca actctctgat catcataaaa acacagctca   4200
 cagccttgat ctcctgggct caagctggtc tcaaactcct tcctggactc aagtgatcct   4260
 cttgcctcag cctgccaaag tgctaggatt ataggcatca gccactgtgc ctggcctaat   4320
 gtgccttatt tttaagtatg cctaccatta aacttttact ttaaattaat atacttggtt   4380
 tggacttgaa aaaaataaaa taaaacccaa ggaaaacaat aaaaagagca agcgtcatct   4440
 ttggagtacg ttctttccaa atataaactc ctaacccgga acttactgca ctgtctttca   4500
 taaccagccg tttatgagat gtcaacagct tttccaaagg gtaaacaact cgccgtaggt   4560
 aactctcatc cttgtggtta tcatacagcc actgagcatc aagcacatca tgcattgtca   4620
 ccatgtggtc ctgaaaagca gccatgtatg aaaataattc agtttatttg tatctcagcc   4680
 catcagaccc caaacttcct aaaactgaat gtcacttgtt tactagtcca agctcattat   4740
 gttttcagcc tcttcagtcc tggctcttcc aggcatcttt tttttttttt tttttttttt   4800
 ttgagacgga gtctcgctct gtcgcccagg tgggactgcg gactgcagtg gcgcaatctc   4860
 ggctcactgc aagctccgct tcccgggttc acgccattct cctgcctcag cctcccgagt   4920
 agctgggact acaggcgccc gccaccgcgc ccggctaatt ttttttgtat ttttagtaga   4980
 gacggggttt caccttgtta gccaggatgg tctcgatctc ctgacctcat gatccacccg   5040
 cctcggcctc ccaaagtgct gggattacag gcgtgagcca ccgcgccctc ttccaggcat   5100
 ctttaaccgt tgaagtatta gaccccaagc aggcattttt gtaggctggg aggcaaatga   5160
 atagaataat actttctacc caatcatctc ccttagccca ttttaatgtc ccaaagttta   5220
 attaacagaa cagggaagct gccctggact gaactcaaca ctttggaaag catctttccc   5280
 acgacatgaa gcaagtggag tgccatcaaa ggctggcaga tggtaagaac cagctctaaa   5340
 acttctagcc ccgtaacaca taccttttca ctcatgactc cagaacgaac cctccgaagc   5400
 tcctgcatct gaccaccaac tcccaataac aaaccaaggt gcacacataa tgtccgactg   5460
 taggtgtcag cctcacaact cacccaaaag attcctaaga tacacacaca caaaagaaaa   5520
 gcagcaccta ctgtaaatac atcactggtt gagaaatgca gttatccttc atctgagcca   5580
 ccaagactag aggtgacaga cacacttctt aaaatataag catttgctgt aaagatctgt   5640
 aattctggcc aggcacggtg gctcacgcct gtaattccag cactttggga ggcagaggcg   5700
 ggtggatcac gacgtcagga ggtcaagacc atcctggcta acatggtgaa accccgtctc   5760
 tactaaatgt acaaaaaatt agccgggcat gatggcgggc gcctatagtc ccagctactt   5820
 gggaggctga ggcaggaaaa tggtgtgaac ccgggagaca gagtttgcag tgagccgaga   5880
 tcatgccacc gcactccagc ctgggcgaca gagcgagact ccgtctcaaa aaaaaaaaaa   5940
 aaaaaaaaaa gatctgtaat tctgatatta gcagaatttt taacacttaa gttgcaggta   6000
 tattcagcat ggtatgtttc atggatggga ggaaaattgg cattgtctta aatttacttc   6060
 tgacaacaga aacttctaag cagtcaaaat tgcagcaaat aaaaaacaca tgcaaaacat   6120
 actttggtga aaacacttac ctttgaacaa agcaccgaac tacacaaatg cagaatgaaa   6180
 acatttcaac tccagcagaa gcagtcatca taaaaggtgt aaaagccatc tcactttact   6240
 aggcactgtt cactttttca acaaaagata acaaaaacta tcgcccacag acaatatccc   6300
 agctgtaggg caggttttag aaagtcttca acttcaaggg catctacttt taataagaga   6360
 acagaatcct gaagaatgtg ttcataccca ctcacaggcc taatgactca cctaatcttc   6420
 tttcaggatc gtattcaatc attttgctct cgtagatggt cctcactcgg agctgcctct   6480
 ttactgcagc aataagtggg ggtcgctgga ataaggcacc tgtcagagtt tctagggcct   6540
 aagaacaaac acaaatgaaa acaaacacct catcagaatg tacatgtgca gtcactggtc   6600
 caggctggct gcagcagccg actgaaaagg ggacaaaagg agtcagtcag gacagctaac   6660
 ccatctccag atgtttaggg gctcagagat ccaagtcaac aaagggtgtc ctccctacaa   6720
 ttgcagactt accctagaaa gctgggtccc cccttcaata gcattgtgca gccggacaat   6780
 ccccacatac tctttgcctg aaaaatgaca aaagagtagt caggtgtggc cactgagttt   6840
 tctgttttcc atatttctta tatgctcagt cactcccatt ttgcacagca ggaaaagcgg   6900
 cagtttgacc ttgtgtttct ataaaatttg cattaagaga gatttcatgg tgatgatgtg   6960
 ggaaagaatg aagacacttt ctcactggga attcaatgta ctaacaggga cagttgggag   7020
 tactcagtgt agaagctgcg tggaaaaagc cttgcaagat aagcaggctt ttctcagata   7080
 aaaatgaacg aaggatactt taggcagaag cggtagcaca gagtgagaag cctggagtga   7140
 caagctgaga gctgaacccg gacaaatgga tccagtcagc ttgatgaata catgcttagt   7200
 atgtggaatt ccaaaaagcg cggaccacca agatctggca ggggacagaa cgtacacaga   7260
 aaccaaaaca atatccttgc tttaggattt ttttttttct taatgaagaa atagtttcca   7320
 gcagacaaaa catagaaggg aaatacagaa agcttttcac tctagccagt ccttccctcc   7380
 ctctcccaca tacctgcact ctgttgtgac ttcaccaagc gagtggctcg ttctatgcac   7440
 acgattaaac aaccagtcac cttgggatcc agagtaccac tgtgccctgt cttctccacc   7500
 cgaagtatcc gtcgaatcca ggctaccacc tcatgggaag aggggttaga gggcttgtca   7560
 agattaatga aacctgtcct ggaatggaaa aaaaaaaaat taatgtatca cccactctta   7620
 atgctccagt gaaacaacaa atctgaaaag ttaaaaagaa aaataattca ctgcgggtac   7680
 aggttatata ttcaagacaa agctattctg gcatgccact gccttcctga atagctgatg   7740
 tgaaagcatt ttcaaaagaa agtaagtttg cacagtgcct cctcccaaca cttacctgat   7800
 atagtcccca atctctctct tcagaggatt ttaaccacat gcaagaggtg tatagtgtgt   7860
 tgtccttaca ttcagcttat caaaattcta caaagcaacg acacaacaca aaacaaaata   7920
 ccatgtcgtg agcacatgta aaaaaagagt cagtaccact atgtggccca caaactggca   7980
 taggtctgca agatggacta agtacaaaaa ctgagaactg ttgacaaact cagcaattta   8040
 acattgtggg gacatgtgtt ctacaacagt gttgagtgca ctgccaattt tttaaaaact   8100
 tggttctcat ttcagatacc ttaaggaatc ctgctttaaa ctgtatcagt gggcacttcc   8160
 caaagtcaag gatgccagca gtaagcattc tcaatcaatt gtttaacact tggaaataac   8220
 gtaaaagcag gcattcatct gatgcacgat tttaaccaca tacctttagc aaaaggggcc   8280
 actgagacgt gtccaactta gcaactttgg attcaggttt gataagaaat tcttcagcgt   8340
 gttgtatttc cttcgacagg acagaaatat aacctattaa acttcccacc cgattttgaa   8400
 caattccatt actgccatgg aaatgtatgc cttttaaaca gaaaacaagg cttcctatgc   8460
 cttttcactg ggacctccaa gggaaagaga gagaagaaat gaaccaggag tacagagggg   8520
 aagtgaaatg tcactaagat gggtccaaac atttaaagag aaagggggat ggcgggtctg   8580
 tgggtggcat aaggaagaca aattcagaga cagcagttgg taaggccagc accatttagt   8640
 aagctatgcc tgaaggacac ttggactgtc tggggctgtg tcatttcagt gctttttcga   8700
 atctacacaa tgactaccaa tgctggccca ttccttggaa acctttaaaa acacttcttt   8760
 cctttagttt gttatttaag taaactttct ttttagtcaa agtgaagtca aacacattac   8820
 tactcacggc tacatcttct tctggcaatg acttccgctc ctttttcttc ttatgtttct   8880
 ttggcaaaat aattactaaa aaaacaaaca caggatttgg gaattttccc caagaataaa   8940
 tgaaacaagg gtttaaaata aagaccgaaa ttagggcagg taggaaatgg attttaggtc   9000
 tacaattaca gtcacatgcc acataatgtt ttgcaagtac agactgcgta tgtgatggtg   9060
 gcccccataa gattataaca gagctgaaaa attcctatct cctagtgatg tcttgatgat   9120
 cctgaccctg tgtaggtcaa ggctactgtg tgtgctgtgt ttgtgtctta gttaacaaaa   9180
 aaaaattttt taagaaaaaa attaaaaaat tttaaaatag aaaacttata aataaggaga   9240
 taagcagaga aaatatttac gtacagctaa ataatgtgtt tgttttaagc taagtattat   9300
 tacaacagtc gaagtaaaaa gtttataaag ttacagtaag ctaaggttga tttattctga   9360
 agaaaaatat atttttataa atttagtgta gcctaggtgt acagattata aagtctccag   9420
 tagtgtaatg tctgaggcct tcacattcag tcaccgactc aaccagggca acttccagct   9480
 cagcaagctc cattcatggt aagtgccctc ctcttcgggt gcaccactta taaccttgtg   9540
 tactatatat atataatata catacatata atacatacat atataatata catatataca   9600
 cacacatatt tatatatata taattttttt tttttgagac ggtcacactc tttccccagg   9660
 ctggagtgca gtggcagaaa ctcggctcac tgcaacctcc ttctccaggt tcaagcaatt   9720
 ctcctgcctc agcctcccga gtagctggga ttacaggcgt ataccaccac gcccacctaa   9780
 attttttgta tttttagtag agacggggtt tcaccatgtt ggccaggctg gtcttgaact   9840
 cctgaccgca ggtgatccgc cagcctgggc tgggatcaca ggcctgagcc accgcgcccg   9900
 gccctgtgct atatttttac tgnccttttt ctgcttagac atgtttaagt acacaaactc   9960
 tcgacgctgt gtcccaactg nctacagcat tccgcacaat accatgctgt caggtttgaa  10020
 gcctaggagc catacgctac accatataca gctaggtgtg tagtagccta tgccacctag  10080
 gtttgtgtaa gagccctctg atgttcacac aatgatgaaa                        10120



      <210> 634
      <211> 576
      <212> DNA
      <213> Homo sapiens


      <400> 634
 attttgaaac acttgatgga aaaggcatca agaatgttaa agttttggat tccacgtcct     60
 ttttgggtcc ttgctgcgaa agtgctcaac cttgtgctgc caaacttgtc cctcgggccc    120
 atcgactcca gcgtgctctc tcggaataag acagaggtcg acatttataa ctcagacccc    180
 ctgatctgcc aggcagggct gaaggtgtgc ttcggcatcc aactgctgaa tgccgtctca    240
 cgggtggagc gcgccctccc caagctgact gtgcccttcc tgctgctcca gggctctgcc    300
 gatcgcctgt gtgacagcaa aggggcctac ctgctcatgg agttagccaa gagccaagga    360
 caagactctc aagatttatg aaggtgccta ccatgttctc cacaaggagc ttcctgaagt    420
 caccaactcc gtctttccat gaaataaaca tgtgggtctc tcaaaggaca gccacggcag    480
 gaactgcgtc cccaccctga atgcattggc cggtgccggt caatgggtct ggggggatgc    540
 aggcagggga agggcagaga tggcttctca gatatg                              576



      <210> 635
      <211> 576
      <212> DNA
      <213> Homo sapiens


      <400> 635
 attttgaaac acttgatgga aaaggcatca agaatgttaa agttttggat tccacgtcct     60
 ttttgggtcc ttgctgcgaa agtgctcaac cttgtgctgc caaacttgtc cctcgggccc    120
 atcgactcca gcgtgctctc tcggaataag acagaggtcg acatttataa ctcagacccc    180
 ctgatctgcc aggcagggct gaaggtgtgc ttcggcatcc aactgctgaa tgccgtctca    240
 cgggtggagc gcgccctccc caagctgact gtgcccttcc tgctgctcca gggctctgcc    300
 gatcgcctgt gtgacagcaa aggggcctac ctgctcatgg agttagccaa gagccaagga    360
 caagactctc aagatttatg aaggtgccta ccatgttctc cacaaggagc ttcctgaagt    420
 caccaactcc gtctttccat gaaataaaca tgtgggtctc tcaaaggaca gccacggcag    480
 gaactgcgtc cccaccctga atgcattggc cggtgccggt caatgggtct ggggggatgc    540
 aggcagggga agggcagaga tggcttctca gatatg                              576



      <210> 636
      <211> 2062
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2062)
      <223> n = a,t,c or g


      <400> 636
 tgtttgttac taccgttcat taaactgcca accacaggaa acagcctggc aaagattcaa     60
 actgtaggca aaaaccggca gagactgaat agagtcctca tgggcccaag gagcatccag    120
 aaaaggcact tcaaagaggt aggaaggcag agcatcagga gggaacaggg tgcccaggca    180
 tctgtggaga acactgccga agtaaaaaag gctcggaagt ccagccccaa gggagctgaa    240
 acagcctcac acacagcagg ggcctgagaa gttagcggga aacgccgtct acaccaagcc    300
 ttcgttcacc caagagcata aggcagcagt ctctgtgctg aaacccttct ccaagggcgc    360
 gccttctacc tccagccctg caaaagccct accacaggtg agagacagat ggaaagactt    420
 aacccacgct atttccattt tagaaagtgc aaaggctaga gttacaaata cgaagacgtc    480
 taaaccaatc gtacatgcca gaaaaaaata ccgctttcac aaaactcgct cccacgtgac    540
 ccacagaaca accaaagtca aaaagagtcc aaaggtcaga aagaaaagtt atctgagtag    600
 actgatgctc gcaaacaggc ttccattctc tgcagcgaag agcctcataa attccccttc    660
 acaaggggct ttttcatcct taggagacct gagtcctcaa gaaaaccctt ttctggaagt    720
 atctgctcct tcagaacatt ttatagaaaa gaataataca aaacacacaa ctgcaagaaa    780
 tgcctttgaa gaaaatgatt ttatggaaaa cactaacatg ccagaaggaa ccatctctga    840
 aaacacaaac tacaatcatc ctcatgaggc agattccgct gggactgcat tcaacttagg    900
 gccaactgtt aaacaaactg agacaaaatg ggaatacaac aacgtgggca ctgacctgtc    960
 ccccgagccc aaaagcttca attacccatt gctctcgtcc ccaggtgatc agtttgaaat   1020
 tcagctaacc cagcagctgc agtccgttat ccccaacaac aatgtgagaa ggctcattgc   1080
 tcatgttatc cggaccttga agatggactg ctctggggcc catgtgcaag tgacctgtgc   1140
 caagctcatc tccaggacag gccacctgat gaagcttctc agtgggcagc aggaagtaaa   1200
 ggcatccaag gcagaatggg atacggacca atggaagatt gagaactaca ttaatgagag   1260
 cacagaagcc cagagtgaac agaaagagaa gtcgcttgag ctcacaaaag aagttccagg   1320
 atatggctat actgacaaac tcatcttggc attaattgtg actgaaatac taacgatttt   1380
 gattatactt ttctgcctca ttgtgatgtg ttgtcaccga aggtcattac aagaagatga   1440
 agaaggattc tcaaggggca ttttcaggtt tctgccacgg aggagatgct cttcgcgaag   1500
 ggagagtcag gatggacttt tttcattcag acggccgctc tggcttaaag atatgtacaa   1560
 acctctcagt gccacaagaa taaataatca tgcatggaag ctgcacaaga agtcatctaa   1620
 tgaggacaag atcctcaaca gggaccctgg ggacagcgaa gccccaacgg aggaggagga   1680
 gagtgaagcc ctgccatagg aggagaacac agcccacctc aggcctcctg caaaaataca   1740
 tagaataaac aacaacagtt actaaatgaa aaaaaaaaaa aagggggggc cgttttaaag   1800
 aatccaagtt aacgaacgcg ggctggcaga ggaatagctt ttttataggg cccccaaaat   1860
 caattccctg ggcggcggtt taacaacggg gggacgggaa aaacccgggg gtaacccact   1920
 taaatcgccc tgtgggaacc ccnnngnnnn nnnnnnnnnn gntttttntn gggnttgggg   1980
 tttgggtgtt ttgttgtttg gggtgggttt ttntgtgggt tgtgttgtgt gtntggggtt   2040
 ggggtgttgt ggtgtttntt tt                                            2062



      <210> 637
      <211> 1917
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1917)
      <223> n = a,t,c or g


      <400> 637
 aaatcgactc gctcggtgtt cgcccgccga cgccgcacgg cttgctgggg ctgggctctt     60
 cctcgcggaa gtggggagga ggcggttgcg gttagtggac cgggaccggt aggggtgctg    120
 ttgccatcat ggctgacccc gacccccggt accctcgctc ctcgatcgag gacgacttca    180
 actatggcag cagcgtggcc tccgccaccg tgcacatccg aatggccttt ctgagaaaag    240
 tctacagcat tctttctctg caggttctct taactacagt gacttcaaca gtttttttat    300
 actttgagtc tgtacggaca tttgtacatg agagtcctgc cttaattttg ctgtttgccc    360
 tcggatctct gggtttgatt tttgcgttga ttttaaacag acataagtat ccccttaacc    420
 tgtacctact ttttggattt acgctgttgg aagctctgac tgtggcagtt gttgttactt    480
 tctatgatgt atatattatt ctgcaagctt tcatactgac tactacagta ttttttggtt    540
 tgactgtgta tactctacaa tctaagaagg atttcagcaa atttggagca gggctgtttg    600
 ctcttttgtg gatattgtgc ctgtcaggat tcttgaagtt ttttttttat agtgagataa    660
 tggagttggt cttagccgct gcaggagccc ttcttttctg tggattcatc atctatgaca    720
 cacactcact gatgcataaa ctgtcacctg aagagtacgt attagctgcc atcagcctct    780
 acttggatat catcaatcta ttcctgcacc tgttacggtt tctggaagca gttaataaaa    840
 agtaattaaa agtatctcag ctcaactgaa gaacaacaaa aaaaatttaa cgagaaaaaa    900
 ggattaaagt aattggaagc agtatataga aactgtttca ttaagtaata aagtttgaaa    960
 caatgattaa atactgttac aatctttatt tgtatcatat gtaattttga gagctttaaa   1020
 atcttactat tctttatgat acctcatttc taaatccttg atttaggatc tcagttaaga   1080
 gctatcaaaa ttctattaaa aatgcttttc tggctgggca cagtggctca cgcctgtaat   1140
 cccaccactt tgggagaccg aggcaggtgg atcacgaggt caagagaaag ttaccatcct   1200
 ggctaatacg gngaaacccc atctctacta aaaatacaag aagattagct ggctgtggtg   1260
 gcatgcacct gtggtcccgg ctactcggga ggctgaggca ggagaatcgc ttgaacccgg   1320
 gaggtggagg ttgcattgag ccaagatcac gccactgcat tccagcctgg tgacagagcg   1380
 agactcagtc tcaaaaaaaa tttaacgaga aaaaaggatt aaagtaattg gaagcagtat   1440
 atagaaactg tttcattaag taataaagtt tgaaacaatg attaaatact gttacaatct   1500
 ttatttgtat catatgtaat tttgagagct ttaaaatctt actattcttt atgatacctc   1560
 atttctaaat ccttgattta ggatctcagt taagagctat caaaattcta ttaaaaatgc   1620
 ttttctggct gggcacagtg gctcacgcct gtaatcccac cactttggga gaccgaggca   1680
 ggtggatcac gaggtcaaga ggttgagacc atcctggcca acatggtgaa accccgtctc   1740
 tactaaaaat acaaaaatta gctggatgtg gtggcacaca cctgtagtcc cagctagtca   1800
 agaggctgag gccagagaat cgcttgaacc tgggaggtgg aggttgcatt gagccaagat   1860
 cacgccactg cattccagcc tggtgacaga gcgagactca gtctcaaaaa aaaaaaa      1917



      <210> 638
      <211> 2295
      <212> DNA
      <213> Homo sapiens


      <400> 638
 tttttttttt ttaagattcc agcttttttt attttttccc cttttacaca aaacaaagta     60
 gaagaaataa tacaggatta aaactgcaaa agtagttaat cagtagaata tgtatgcaca    120
 caaaaaatcc agataggaag acaggcttat ttacaatgaa agtaaggtaa aattaacgta    180
 gttttcttat gaaataataa aaaaaaatca aacatatgct acaatgggca ccactgttca    240
 cagcaatatt aaagaggaga aaacaacact tatttaatag ggacagatat accacaaggt    300
 acaacatcag tgcaataaat tcacaaaact atattacagc tagttaatca gtttaagaat    360
 tgttcccgtc agtcacattt tttggccctc agaagttcat tcctaaagat ttcaactact    420
 ctaaatttct agctaccaag aagttaagaa tgattataag aagctttcca aggagttatg    480
 aaatctttgt agaccagagg ccaactatca tcacctcaag tctgctctca ccaacagccc    540
 ttgtattttt cagggagaaa tctctaggaa aaaagtcaga caccagtgta gtcactatct    600
 cccatgtcaa acctagggga ctaaaatggt cagtattacc ataaaatgat aattttgagg    660
 tttaccttaa aaggcttatt ctggtctcaa aaattagata agattatctt ctactgaaat    720
 gaatattgac taaacataga agactgctgt ccttttgcca gtcttagagt gaaagtcata    780
 gacatgagtc ttaacctact gtatactata gctaatgtca gctgaaaatc tgaaattaaa    840
 agcatgctag aaatcctaaa tgcaatcttt tggaagtctg ctattaaaaa gcctttaagg    900
 atttactaac ttcgagtcta agtgcaaggg gacgaaagct taagcctgtc agacattcct    960
 tttcttggac aaaaagatca aagtttccta caaattgcta agctttgcac aagggagaag   1020
 cctacatgta ctagtgcatg gaatcagttt catcttattt catggggact cttctcccac   1080
 tggaaagaaa cagaatgagg aatgaatctt aattggtctc ttcatcagaa gtggtaaact   1140
 tggtctctat attcacgaag tcagacagtt ttttaagcag actgtggaag cagacagaac   1200
 cagcttcctg tagccacaga ccactacatg gtatctaagc taaagcaaag atgaacaatt   1260
 atccagattc acttgaactg tactaaaggg caaggttcac cactacaaaa aggaagttgt   1320
 ctaaaagcaa gaattcaatt aacgctgggt aagaaaagtc aaaacactaa tgagttgtcc   1380
 atgaagccaa ctgctaagaa cgcgctcaac tatacgcgac atgaagacac tatgcacgaa   1440
 gccttacttg gcgagtctga atttctatta actaagggca gagtgaggga gaacaaagag   1500
 ctacttccgt aacattttag tatccagata gtacagcaga aacggttccc ggggcaatgg   1560
 gtgctgcatt aatcacactg attaaagcag atgaatcatt ccgtttttcc tttttctttt   1620
 tgtttgagaa gtttgtttat ctccctcttg gccattccca atgtacttca aaaatgattc   1680
 ccatgttggg tttaggtcca gggaagcaat aagtaaggaa gtcactatca ggtaggtgaa   1740
 gaagcaggtt gtggacttgt tgtcccaccc aagcaaaccg cagcaaggga aacgatcatg   1800
 gtcatgaagt acatcttagg tttttcttcc tttagtgtga aagagccgtt tccacccaac   1860
 ccacagctct gcgtccgagt ttttactaga ttgctgcaaa tttcatggaa tctttgctgt   1920
 tgttccagtg gtccatttat tggagcccaa aaattctagg cgctagaatg gggaacaagg   1980
 tagtcagcca agccacaaaa acataacaaa acaggaaacg ccggacagaa cagatggatc   2040
 tagatagtag ataatcagaa acaccaaaga aacccacacc catgatggca ggtggaaacc   2100
 aggctctttc ccatcggagg actttatcag ccatcagcat cacttctccc catccttgca   2160
 gctgttctta ccaaacttgc agtctctgca gccagcaggt tggtgctgcg attatctccc   2220
 tccgccatcg tctcggggat gcagtctcta caagcgcagg ccacctccgc aacgagtcct   2280
 ccactcgtgc cgaat                                                    2295



      <210> 639
      <211> 3542
      <212> DNA
      <213> Homo sapiens


      <400> 639
 cgatataaag gccatcttat ttcttctccc actttttgtg ggtgacttct tggtatccgg     60
 ggcttttcag tgacagccgg ggcgacaggc caggctgagc ctgtggctcc agggtccaaa    120
 gagaaaggag ggcagaaata agagaagatg gcctttattg cagcacgaac ttgaggggga    180
 ctgcatgtcc cacagctctc cagggagctg ccaaaggcaa cgggcccgcc ctgcccctgc    240
 aacaggccct ccaggggctt agagcatggc tcccctcagg aagggtaacg cgtgcttgta    300
 aacaagggcc cagacaacac agagaggaga ggcagcatca tcatgtgcag ctttgctaca    360
 agaaagatag ttcttaattt caaagaggag acaccgctac acctagccct gccctcccat    420
 gcactggaag gctctggaag tagctctcgc ctgcctgggc agttaggtcc acccactgcc    480
 cgtgagctgg gcccaggcac actgcagcca cacaaaaacg ctggcagctg actcctaatt    540
 tcagaaacac aattagaaaa gaactggaat tttacatttt tctcccatac attaaaaaat    600
 aagaaaaagc caacattttg actgtagacc ctggtaggtg gcatctgact ttaacctgaa    660
 gttctcattg gaatcctttt ctgtctggcg ctccaccgcc cacaatcagc cccagcccca    720
 ggatccttcg gcaaggggcg cctggggctg gggctcattg gaatcctttt ctgtctggcg    780
 ctccaccgcc cacaatcagc cccagcccca ggcgcccctt gccgaaggat cctggcccat    840
 ctcacacaag ggcgggaccc cgtggagtgc ccggcgagca gggcaaccac tgggaagaca    900
 gatactgatt tccctgttgg ggtctgtgac cctcagcaaa cgaaaaggaa acggtaacaa    960
 gacggtggcc tcctgccagg acctcagcag gaggtttgct ggtgaaggtt ctgggtgagc   1020
 tggaatgggt gataaggcgg gcttgctggg tggtggcctc aggctgttcc tgggcccctg   1080
 tcgcatagag ccctgtgggt gcagtgtggg gccccacagc cgtcccgggg tcgtcctgat   1140
 gcataagagc agagaccccg gaagagaaac ccgcctgccc cgtgtgatac agggctccca   1200
 aacgcttccc ggtggaaccc tgctcccgag gacaccttgt ctcgctccac ggaacccttc   1260
 ccccagcacc ccctggaaac acagcagcca ggaacaaatt ctccatgcca ggaacgaagc   1320
 ccttggctaa actggagact catcagtgca cagatggtgg tgaggggtga gggcagggcg   1380
 tggggtggtg ctcagccctg gggacaccat cactgtcctg ctctgaccca caggtgagag   1440
 gaggatgctg tgctcccgga gtgtggcgcc gggaggatgg ctcggcagga cagaggcctg   1500
 gggctgaggc tatgcccagg gccggtgtgg ggagggacat gggggccttt gcagaagcag   1560
 ctcagagaac tgaggttgga atcctgcccc aagcacaggt tttggggaca gcgagtgcct   1620
 agacaaggca ggtaacgtgg cagccaccgg gctggtccag aaacaaggtg ctgaagacgt   1680
 cgttgaagaa ggtggggtgg tacctgcagg ctcgctcaca gtcggggttg aagttcacct   1740
 ccaggatctg cggctgcatc acccgccttc catctgggcc gttgtcccac ttcagcatga   1800
 ggtcgacggc atacatggcc cgggatgagg ggtagtcgca gaggcccagg ggtggtggct   1860
 tggcacaggc cacctggaac agctccgtga aggcccggaa gatctcagcc tggacgtccg   1920
 tccagggaaa ttctgggtat tgcttctcaa actcggggat gaactcttca cagtgcacct   1980
 gcttcagcac cacatccggg tcatagttca tgaccgtgaa agtgcttctc gtaagtcatc   2040
 ccaggtcgtt gagtgcaaaa ggcccggttg gagaaccgca agcccagaac acatcataca   2100
 cgaacaaccg taggggcctc actgaccgca gcagcacgat gtagcggatg tcgaacttga   2160
 cctttcccac gtcttctcga aggaacaaca cgggactttc gatgtacttg gacacaacct   2220
 tgggggtgct ctctcggtgc cggatgatgc tgtgcaggct cttggtgacg tgggtgtcca   2280
 ggctgcgcgc caggttccag ggcttgcaga tccagtggtt gtcctcgccc cacctttccc   2340
 gctgctggaa gtagctgaca aactggggca gctcagtgcg caggttgaag gttcggggca   2400
 gccagggtgg gccctcgggg ccacctgccc gggcgcgcga tggaggccag gcagtccttg   2460
 acagtcagca ggttctcgca ggggaactgg ttcagcagca cgcctggcct ctcctggctg   2520
 agtttcctgt agtccttgaa gtgtgagaag ttgaagagga tgtcggcgtc cgcctcactc   2580
 tgggtgaggg tgaagcgcgg gtgggtgagg ctgctggcca cctgctgcac gtccgtgtag   2640
 accttgaaga tgtggccgtg ggggtgcacc acggggttga tgtcaagtgg cagcttctcc   2700
 ttgttttcct ccagaatggc ctggtagtgc tcggcgggcg gctcgggtgt gcaagagctg   2760
 aggtccagca tgtcggtggg ggcccagggc agcagcatgc acttccggat cagggggtcc   2820
 gtctctccgt aggcaaagtc tcgggtcacc tcctcgccag tgtccaggtc cctcaggggc   2880
 cacagcagcg tgtaggccac ctgctgcggc atgtagaaga agggtgccgt ggcgaagctg   2940
 ggcacgtccg cgtgctggat ccgcgaaccg aactcgtcca tgatatacca caccggcatc   3000
 ttctcctcag ctgtcccatg ggccagctgg taggtctggt tgaacttcca catctcctcc   3060
 agcaccaggg ccacagcctc tgtactgggc agctcaccgt ggaactcaat gcccatcagg   3120
 ttggccatgc ggtgcagcag cccgggcacc tgctgcagct gctggcgcgc gtgctccaca   3180
 cggcacgtcc aggcgtggtc gatgaggaag atgctgttgg ggtgggctgc ctggagcccg   3240
 ctctccctgg tcacgatgac cttgtagcac agctcgttcc ccgggttggg ctgctgcttc   3300
 cgcacctccc gggctgcctc gtcctcctcc tcttctacct cctccacttg catgatccca   3360
 aacacttccc cagcgtcgaa aacctcgtgc tccagcttgt gcaggaggcg gccccagtaa   3420
 cgttcgggga cccccgaagc gcgcagcgcc gggccgtgca gcgccgcgaa ctcggccaag   3480
 gcctgcgcgc cctcctccgg cgtctggccc gggctgctac gctccgcagg ccggcgctcg   3540
 gg                                                                  3542



      <210> 640
      <211> 3005
      <212> DNA
      <213> Homo sapiens


      <400> 640
 gtccatcttc caccgcggcc acgagcgctt ccgcattgcc agcgcctgcc tggacgagct     60
 gagctgcgag ttcctgctgg ctggggccgg aggggccggg gcgggggccg cgcccggacc    120
 gcatctcccc ccacgggggt cggtgcctgg ggatcctgtc cgcatccact gcaacatcac    180
 ggagtcatac cctgctgtgc cccccatctg gtcggtggag tctgatgacc ctaacttggc    240
 tgctgtcttg gagaggctgg tggacataaa gaaagggaat actctgctat tgcagcatct    300
 gaagaggatc atctccgacc tgtgtaaact ctataacctc cctcagcatc cagatgtgga    360
 gatgctggat caacccttgc cagcagagca gtgcacacag gaagacgtgt cttcagaaga    420
 tgaagatgag gagatgcctg aggacacaga agacttagat cactatgaaa tgaaagagga    480
 agagccagct gagggcaaga aatctgaaga tgatggcatt ggaaaagaaa acttggccat    540
 cctagagaaa attaaaaaga accagaggca agattactta aatggtgcag tgtctggctc    600
 ggtgcaggcc actgaccggc tgatgaagga gctcagggat atataccgat cacagagttt    660
 caaaggcgga aactatgcag tcgaactcgt gaatgacagt ctgtatgatt ggaatgtcaa    720
 actcctcaaa gttgaccagg acagcgcttt gcacaacgat ctccagatcc tcaaagagaa    780
 agaaggagcc gacttcattc tacttaactt ttcctttaaa gataactttc cctttgaccc    840
 accatttgtc agggttgtgt ctccagtcct ctctggaggg tatgttctgg gcggaggggc    900
 catctgcatg gaacttctca ccaaacaggg ctggagcagt gcctactcca tagagtcagt    960
 gatcatgcag atcagtgcca cactggtgaa ggggaaagca cgagtgcagt ttggagccaa   1020
 caaatctcaa tacagtctga caagagcaca gcagtcctac aagtccttgg tgcagatcca   1080
 cgaaaaaaac ggctggtaca cacccccaaa agaagacggc taaccctgga gtatcaccct   1140
 tcctccctcc ccaggcacca ctggaccaat tacctttgaa tgctgtattt ggatctcacg   1200
 ctgcctctgt ggttccctcc ctcatttttc ctggacgtga tagctctgcc tattgcagga   1260
 caatgatggc tattctaaac gctaaggaaa aaaaacaaac acagaactgt ttcaagtact   1320
 caagactgac ttacagacca accaaccacc ttgctggaac ccttgctagc aggcattctt   1380
 ataaaagaaa ctttcgagcc tccttatatt gctggaaact cagctgtgct ccagactaga   1440
 gcctccttac ctatgctatg gatttttaat ttattttctc ttatttcatg tacactgctt   1500
 tttttggtta cagtgtatga tggatgtgta tgaaaaaaat gtatctttgg gaaaacaatt   1560
 acagtttgtt aatttgaaga tgctggtctt gactcatctt tatttttatt cgcacatccc   1620
 accccatccc ctgaactact tgggaggtgg gaggggtacc agtccacctt tgcttttggt   1680
 agagatgaga ggccgcattt tgctgctaaa gcaagagaaa cttggagctg aagcacacac   1740
 ctggtctgcc cctagatttc tcctcaaggc ctctggagca accagcacct gcccccttgg   1800
 aatgcagagc ctggcctgcc aaactacaat gtggtaggct gaaacgatgg tgttaattct   1860
 taggactact tttctagtca cagatgtttt caaatttcta agaaaaagaa aatgaggctc   1920
 aagaggctgc ttcgtagaat tccttttgaa tgaattgagt ggggatgggg acacagtctc   1980
 caagtgtgta tgtggtcttt tctgatctca gctgtgtggc tgcaactctt cgctgttcat   2040
 tggttcctct cctggaaagt ggcttctaac cagcactgga tggtgatcat tggtaagctt   2100
 tgctcacctc cctctctctt gcttcatttg gctttatcaa aaagaacaga cctagctctg   2160
 aatttgtttg gcttgggaaa ttatggattc tttcaagcca ctcccacaag gtgggtccta   2220
 ctagaaaggg ttagcatttt aaggggggtt gttctataca cctgtgtcct taccccaggc   2280
 tcaggaactg ccagggaggg aagatgaggt ggggagtctg tactgagatg gaactgtcag   2340
 tgctgtgttg tatgtacttg ctgttgtaaa agtttgggca tgactttgca tctagcgggt   2400
 gctgcctgca tctctttgtc tgtaagcttg ctctgggact cagcctctta ggacctacga   2460
 tgccagcagc tctcattaac agtgaaatga cagaggccaa agatggccaa gtgaagaccc   2520
 aagtctcaga aaacccagac ttgggacaac tgcctgggaa ctaggatgct agagcagttc   2580
 tgtaatgctt tgagacacag caattttcac attggccatt ctttcccctc ccctaccccc   2640
 ttttcttttg agggactttt aatgtttgct gctttaggtg gatggagagt ccaccaggtc   2700
 ccactcaatt gctgctctaa acttctaccc acacccacct taattaaggg gtgctaataa   2760
 aacatgctga ggttgagata aagacgggac ataaggggaa aaattcattc catagagctg   2820
 aaatctggtt ttcaaggcct ctgtggcttt cttctgaact taccaccagc cctggctgga   2880
 atgtagattg tgtttttagt aatgtgtact gtgagctgtc ttctgtataa tgtattttgt   2940
 aatgtatttt tctcatctac caaaggatga aacaaataaa attatttaaa tagttaaaaa   3000
 aaaaa                                                               3005



      <210> 641
      <211> 2030
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2030)
      <223> n = a,t,c or g


      <400> 641
 gtgacatttt ttcatacaat atgtaatgta atcatattaa acatttagac accctcacat     60
 aattatttaa gggcctagta gatgaaattg tatttcacag aaacaaggat aagttgagat    120
 ggagacacag tgcctatgct cagaagtcac tggaaagcac ctgatcacca tagtaaagat    180
 ggccaagggc ttctgacctg attaaaataa ggagtcatat aagaaatggc tttattagaa    240
 aaaatgtagt gtacatgtgg ctaatttcca tcatcgatat acctcttggc tattttatca    300
 ttaaaattgg atacagggtt tgaacttctt tagaagttag tggcatatct tcctattctg    360
 atatgtgact tagggaaggc gttatcttca tatgatagac accctttatt tcttttcata    420
 attacaagta atcagtagtt tagcactggc acaaaacaga gagagaatta cttaggtagt    480
 gctttatgtg taagaagtca cacttccaac cccagaagca ggcacaggta tgccatctgt    540
 agagttttaa aatcccctat tatcactcaa gtctcccatt attattacct agtagtaatt    600
 aaattaatgt gataatctgt aacctaacaa aacctctgaa tgaagtttct ttcttctccc    660
 tcttttcctg ttagatgtgc aattctgagc aaatgtgcag tgtgcagtat tgatttccag    720
 cctcctttta aactccttca agtctgtgct attaaacgga gacaaccaca tcaagataga    780
 gtctgtcata ggattccctg aagcacagaa tgaggaggag actgagcaaa cacgacccgg    840
 gaaggcacca gttgaaccaa gacaactctg tatgataaaa tgtgagaaaa aataaaagta    900
 ctcccataaa catattactt aaaaaagtga caactccaca agtaattcct tctggaactg    960
 ggtagacagt ttccacaaaa agctcaaaaa atataggcac gctgctattc aagaacactc   1020
 ccaggagaat acaggaggca tacaatgtca ctgtggttaa aggtaggtgt gtgatgctgt   1080
 tcaaacaggt cagggtgaac cacgtggatg acagtgtagc tcccgaaaac aggaggagaa   1140
 gaattagttt cagcataccc ctgataaaat ctgcaaacct tgccatagct attccaacaa   1200
 cacagcctcc aactatggac caaaatccaa tccagccagc atctacttgg ctgacatgcg   1260
 ctggtgttaa aattaagtcc agaactccag accagccagc aaatacacca agtggtatgg   1320
 catatgctaa agcaatcatc aaaaatcgaa aattgcttaa taatctacaa acgcttctcc   1380
 gataactcag ccgctggcta gctgcagcaa cactgggagg aagaggaggt cggggtggga   1440
 aataagctag tgttgcagaa aatattaagc agacaactcc aaattctgca tataacacag   1500
 cctctatgcg atctttaata tgcgccctgc tgctctctgc agcaagaaga ggtgatgtcc   1560
 cattgggagc tggaacaaca agtggtccaa ctaaaaatgc acatgctccc ccaagataac   1620
 tgagcattga tgcaatagct gtggctgtgg ccctttcatc tgcagaaaac cacgtcgtag   1680
 agagaaatgg tgctgcattc attacagttg gacctgccaa tccatttaac atctgtcctc   1740
 catgaattaa tcttctttta aggattaagt ctgatatagg tatgcatctt agaccagttc   1800
 ccaaaaccat aaggaaggat gtcaggagca cagttatccg gagacctctc ttgtccagga   1860
 gccacatgaa cgcgaagcag ggcaggaagc cgatgggccc ccacagcacg agcagcgcga   1920
 tgtcccagct ggagaagccg taggcaaggc gcgcagagtt ctggatggga ccccaggtgt   1980
 tccagtccag gccctaccga acgccagcag tnnnntttcc acactcatct              2030



      <210> 642
      <211> 2261
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2261)
      <223> n = a,t,c or g


      <400> 642
 tttttttttt ttttaggctc acgcctgacc accggggttt ttcaggcagt gcaaaaatgt     60
 ttattctgct ttcttccttg gtgggtgggt catcaggctg ctttggctac gaagctcagg    120
 cttctgtgac ctgggcggcc cgagcagtac agagcaccat tggcttccct tgggcctcag    180
 gagcagcaag gcacagaggt gagtcctgca tcgggtggca cggcgtgggc gtgtgagcac    240
 cggaagggga gaggcaggcg cttgccatgc ctggggcacg gggcctcttc agggacagag    300
 cagctccagt gtctactgag agggcacaga ctgacccaaa cacgcattcc acagccagtt    360
 ccttgggata ttcacagcac atgcagccag tagacagctg caacaccact aaggacacct    420
 gtgagcggcc acgggctcag ctccagagca ggccccaccc atcctgctgg gggagaccct    480
 tgctccaggc ttcctcacag gacctggtca aaggaaccaa gtcacacccc ccatgctaga    540
 ggatccccct gtagctccgg gaagggctgc gaagctggag ctgtctcagg ttcccgttga    600
 ggcccagtac cctgagttcc atgactcctt gggggacaga gcacaggagg gaaaagggga    660
 atggacttct acaggatggg gtgggggacg gcctgtcccg gggacaccct ggttctttct    720
 acgcgatggc cgctctggcc tggggagaag ctggcaagga gagggcaccg ggtaaggatg    780
 gggtgctgca tgacccagct ctgcccaagg tggccaggga gaccactatg aaggctgcct    840
 ggtgtgagcg ggaccctggt ggggtgcaga gtgaggccct gtgtggggac tcagggagga    900
 tgctgggcgg gagagaggcc cagggtgtcc cctcacccat gcaggtccct gggtgtgatc    960
 atggaggact ggtaaggctg ctgctgccca gtggcgacca tcaccagggt caggagtggg   1020
 ggagtcagtg cagagaccca gggaagggcc cacttcccag gacgtttagt gtcagcaggc   1080
 ggagtctctc cacaggctct ggctggcgtg cctctacgcc tcactctggt accgcagccg   1140
 ggagaaccgg tccctgatgg cttggtcact gtctggccca ccctcaccca ggcggaccac   1200
 cctgctgctt gggacaaggt cccgcacctt gtgcttgatc acagagacca ggccgggtgc   1260
 ctctgagtct gccgggcctg tcagaaggat gtaggcggcg tggcggcttg gctcaaacag   1320
 gacggcgtca aaggcgacaa tgtgggtaga gacattggcc agctccagca gcacgcgcgg   1380
 cagggtgggg tggaacatgt acaggctgtg ccgggcctcc ccggtctccg tctcgctggt   1440
 gctccccagc tcgtggaggc cccagaagaa gaaggctgag cggtggtctg cggtcggcag   1500
 gctggcggac agtggacccc cagggaggct cgggagggct aggctacaca ggacggctcc   1560
 agtgccaagg tccagaaaca ggatctgggg agggagggga cactgtgggg gccaacgtgg   1620
 gggctaccgg gaaaagctcg aggcttgcta ccagacacgt gccctcagcc atgccagccc   1680
 tggaggcaga tgctctgagg gaggcagaac cttctcagca gctctgnang cagcagcctc   1740
 ctgggccgca gccccgtctg ctttcagacc agtctatcct cagctaagaa caaaggtgcc   1800
 acctccgaag gaagaacaac gaacctgtct gtcggtgcca gtttcttttc aacggctaca   1860
 gccaaggtgt ctggtttgta gcggccgaag atgggttttc tggaacaata tggaggaagc   1920
 gctcacgagg ggtctcagtg aggagactga gatgaaggaa gcacccagga acacgtccgc   1980
 ccctcagtct cccatggcca catctggacc agggcccagg acacggagcc gacgtctggg   2040
 gcaaggggca agtaccagaa acaggcaaga agcccgggca gcagcacnac gctccggccc   2100
 cacccccagc gctgtctcct cgccagccaa cgggatgtgc ccgggatgcc gggaaggggt   2160
 gcagcacctg cgcggtcctt ggggaaaccc tgtacctcag gacatgggct gccttgggtg   2220
 tccagcgagg cgtcagctcc tgcgaccgcg aattcttcca g                       2261



      <210> 643
      <211> 2261
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2261)
      <223> n = a,t,c or g


      <400> 643
 tttttttttt ttttaggctc acgcctgacc accggggttt ttcaggcagt gcaaaaatgt     60
 ttattctgct ttcttccttg gtgggtgggt catcaggctg ctttggctac gaagctcagg    120
 cttctgtgac ctgggcggcc cgagcagtac agagcaccat tggcttccct tgggcctcag    180
 gagcagcaag gcacagaggt gagtcctgca tcgggtggca cggcgtgggc gtgtgagcac    240
 cggaagggga gaggcaggcg cttgccatgc ctggggcacg gggcctcttc agggacagag    300
 cagctccagt gtctactgag agggcacaga ctgacccaaa cacgcattcc acagccagtt    360
 ccttgggata ttcacagcac atgcagccag tagacagctg caacaccact aaggacacct    420
 gtgagcggcc acgggctcag ctccagagca ggccccaccc atcctgctgg gggagaccct    480
 tgctccaggc ttcctcacag gacctggtca aaggaaccaa gtcacacccc ccatgctaga    540
 ggatccccct gtagctccgg gaagggctgc gaagctggag ctgtctcagg ttcccgttga    600
 ggcccagtac cctgagttcc atgactcctt gggggacaga gcacaggagg gaaaagggga    660
 atggacttct acaggatggg gtgggggacg gcctgtcccg gggacaccct ggttctttct    720
 acgcgatggc cgctctggcc tggggagaag ctggcaagga gagggcaccg ggtaaggatg    780
 gggtgctgca tgacccagct ctgcccaagg tggccaggga gaccactatg aaggctgcct    840
 ggtgtgagcg ggaccctggt ggggtgcaga gtgaggccct gtgtggggac tcagggagga    900
 tgctgggcgg gagagaggcc cagggtgtcc cctcacccat gcaggtccct gggtgtgatc    960
 atggaggact ggtaaggctg ctgctgccca gtggcgacca tcaccagggt caggagtggg   1020
 ggagtcagtg cagagaccca gggaagggcc cacttcccag gacgtttagt gtcagcaggc   1080
 ggagtctctc cacaggctct ggctggcgtg cctctacgcc tcactctggt accgcagccg   1140
 ggagaaccgg tccctgatgg cttggtcact gtctggccca ccctcaccca ggcggaccac   1200
 cctgctgctt gggacaaggt cccgcacctt gtgcttgatc acagagacca ggccgggtgc   1260
 ctctgagtct gccgggcctg tcagaaggat gtaggcggcg tggcggcttg gctcaaacag   1320
 gacggcgtca aaggcgacaa tgtgggtaga gacattggcc agctccagca gcacgcgcgg   1380
 cagggtgggg tggaacatgt acaggctgtg ccgggcctcc ccggtctccg tctcgctggt   1440
 gctccccagc tcgtggaggc cccagaagaa gaaggctgag cggtggtctg cggtcggcag   1500
 gctggcggac agtggacccc cagggaggct cgggagggct aggctacaca ggacggctcc   1560
 agtgccaagg tccagaaaca ggatctgggg agggagggga cactgtgggg gccaacgtgg   1620
 gggctaccgg gaaaagctcg aggcttgcta ccagacacgt gccctcagcc atgccagccc   1680
 tggaggcaga tgctctgagg gaggcagaac cttctcagca gctctgnang cagcagcctc   1740
 ctgggccgca gccccgtctg ctttcagacc agtctatcct cagctaagaa caaaggtgcc   1800
 acctccgaag gaagaacaac gaacctgtct gtcggtgcca gtttcttttc aacggctaca   1860
 gccaaggtgt ctggtttgta gcggccgaag atgggttttc tggaacaata tggaggaagc   1920
 gctcacgagg ggtctcagtg aggagactga gatgaaggaa gcacccagga acacgtccgc   1980
 ccctcagtct cccatggcca catctggacc agggcccagg acacggagcc gacgtctggg   2040
 gcaaggggca agtaccagaa acaggcaaga agcccgggca gcagcacnac gctccggccc   2100
 cacccccagc gctgtctcct cgccagccaa cgggatgtgc ccgggatgcc gggaaggggt   2160
 gcagcacctg cgcggtcctt ggggaaaccc tgtacctcag gacatgggct gccttgggtg   2220
 tccagcgagg cgtcagctcc tgcgaccgcg aattcttcca g                       2261



      <210> 644
      <211> 1977
      <212> DNA
      <213> Homo sapiens


      <400> 644
 gggagattca ttataaaagt cagtttattt tccctttctg tgtttcgtat tttccctttt     60
 tgtcagtaaa tgagcaatac actgactgga aatctgcatg attaaataac attaacaagt    120
 tcataaacac accccatatc agagtataaa gcaagaggtt gaaaaatatc ccctaaccga    180
 atgcaaatta ggtatccctc aaaattgcac attctcctcc tagtttgctt gcataattta    240
 aaatatgtat atacagaatg atcttaaaat attgataact agtatggaat tcacagccct    300
 gaagatatat atactctaca tttttctaaa gaacggacac ccctcaggcc ctagtaatcc    360
 attcatgtga ttcaatgtca tgtacagaca gtcctcagct tctgattttt ggactttaca    420
 atggtgtgaa atggttgcaa tttcaacata atgtacaata ttcaataaat tacatgatat    480
 attcaacact cgattataaa atagagtttg tgttagatga ttctgcccaa ctgtgggcaa    540
 ttctaagtgt tctgagtaca tttagggtgg acgaggctaa gctgtggtgt ccagtcaggg    600
 gtattaaatg catttgactt ccaatgggtt tactgggaca taaccccatc ataagtcaaa    660
 gagcatctgt acttgacact tactagaaga aaaggtcttt cccttttctc taattctagt    720
 cttctgctga ggtaactcca ggaagctggt tgtgccagag atcaatcctc taaaaataga    780
 ctaagcagat tagcttccta gaggatccta aagttcccag acaacaaatc tgggatggag    840
 tgcttcggct gtgagttaca cgtcggaatg ttcaagataa atgatgtacc ttatggtcct    900
 ttacacgtca gaatgttcaa gataactgat gtaccttatg gtccttgaaa ggaagactca    960
 atacttccag gagtcaaagt taatttgaat gaaaatggaa gagaacaagt tgccaataat   1020
 ttgaagcaat tcatgcttct agggctgaat gacgtttaga tcagacacag agtgactgag   1080
 ccaatcaaca ggcatgtagt gtgatctttc ccaccacagt gaacagaggg attctttgtc   1140
 caaggcaggc ttgcagctcg gtccagcttg agcatttgat caggatttga tgcttcaaag   1200
 atgacccact ctctgtaaac tcattaccaa agcaaaatgc aatgatctct tccatttgtg   1260
 gaacatacca ccaacacaaa ccacgcgtgg ctttgcctcc tgttcactcc attttcaagg   1320
 ctagagaaag ttcaagtcca aaacaacagt taaggttaaa acgctaaacc tcaataggcc   1380
 aaacaaagac gcgggcagag tcagaggtca aagatgctgg cagagtcaga agtcactcgg   1440
 cacattcatg aaacaacagc aaaaatcatc aacagtaatt cctgtagtgt agaaaactag   1500
 tgcagccttc actgctggtc agcatctcag gtggctggca gtgttgagag acgcctgaca   1560
 atccaagatc aggctggagc tcctagacaa acccaaatta gggcagactc gaagccccag   1620
 cggtcctgat gtggctgaca ttgttctttc tgtctcgcgg gcaccggtca ctccctcaat   1680
 atgtgagcct gtctccttag cacgagagag aatatttccc tcactattaa tggcgagata   1740
 aacacaattg tacaacttgt catgagaatg aaaaagtaga aaacccacat ccatcctagc   1800
 ttgtcccgga tcagagacac taaatactgg cccactgcag ctccaatgct ccccgaacca   1860
 tccacaattc ctgtgacagt ggccaaagct tcactgctcc tttggatgag ctcctggcga   1920
 cccaagtccg cagaaatagc agatctgatc atattagacg gtcctccaat aaacaat      1977



      <210> 645
      <211> 1382
      <212> DNA
      <213> Homo sapiens


      <400> 645
 gatgctggag ccccaaggca ggaaggacag gacagcctca aggcaggaaa gatggctctg     60
 ggagctgtgg ctgtaacttg ctttatgtgt ccagcatctc cgtgagcatc tggtgtctca    120
 gctcaagtca accctggcca gactccaata acagacacaa gaactgagaa ggtggccctg    180
 gttaccaaaa accagaggac cctcattaac atccccaaat ttcaagccag actgaaatct    240
 gtcaaaaaaa aatgacggtc ccagcctacc cccgacacgg gtgggaacag agtagggctg    300
 ggcccagcta gagcctcggc ctgggggttg cttgcacctg cgggggccca cagactgagg    360
 gaggcggttg ggcttccttc cattcccgac agcagagccc cgtgcgtcgt gggagtaaaa    420
 cgtgcgatgt gtgggcttcc cccgcaaaca ggatctggag ctgggcgccg gcgccgtctg    480
 cagggagggg ctgagccagc aggtccaggt cgcccccagt actgcccacg gccacgtagc    540
 tgtaggaccc cctagtgtac ggggcgctgt gccagcgatg acagcaggac gctcttgggc    600
 gcggggagcc gtgggtttcc tgtcactctc cggagcactt gggtgagaca cagaagtact    660
 tcttcatccg acagagtctc catgaactca gactcaagtc cggcaatgaa cccacagaga    720
 acgtggacag acgcaaaggc aggcaggacc acaaagccaa tgagcttccg gaaccaggcg    780
 tcctgtagct caggggcagc atcctccagg ggcgacgtgt cctcccacac cagctggatc    840
 agctggcagt ctggctccca gaagggctcc tcaaactcca ggaagatttt gttgttggtc    900
 ccaaagccta tcttcctgat tgcttctgcc ttctcagccg gcaggggagg gtcaaagaag    960
 gtgtccaaat gttccctaag aaaacctaag ggcacggtga cgatgacatg gtgcgccggg   1020
 aaccggtctc catcctcaca ctctaccgac actggaaagg tctccccggg aaaggctgcc   1080
 tcctggaagg acccgttcca gtggatggtc ttcacaggct tctcaaaaac tacagtgtcc   1140
 tccggcaggg cggccatcat gcagtttgtg agtccttgat agcccttaga aaaggtgcag   1200
 tccagccccg gcagcacggt atactcccca aagggtgcca gggccaccag gtccatgctg   1260
 tgggtgccgc tcacacagca ttccaggttg aagaaggagt tcaggacggc cagcttcagc   1320
 ttcctggtct cctcatcctc tgtccagccg gccacgtgct ggccaatctc cttcttgagg   1380
 cc                                                                  1382



      <210> 646
      <211> 4975
      <212> DNA
      <213> Homo sapiens


      <400> 646
 aaggcatcca ggatgcggtg cggggcggcc cggtgccccc ccgccccgtc acggcagccg     60
 cggcggccga ggggaccggg ccagggccgg gggcggcggc ccgagccgcg gtagcggcgg    120
 cggcgggagg ggcggcctga gggcggacgg gcgggcgccc gggttgcggg ggctcggtgc    180
 cgctccgcac tgcccggccg gtctcggccc cggcgccatg agtggcggcg gcggcggagg    240
 gggctcggcg cccagtcgct tcgccgacta ctttgtcatc tgcggactgg acacggagac    300
 cgggctggag ccggacgagc tgtcggcatt atgccagtac atacaggctt ctaaagccag    360
 ggatggtgcc agccctttca tttcaagtac gactgaagga gaaaattttg agcagacacc    420
 attgagaaga acattcaaat ctaaggtcct tgcacgatat cctgagaacg tagaatggaa    480
 tccctttgac caagatgcag taggaatgct atgtatgccg aaagggctgg cattcaagac    540
 ccaggctgat cccagggagc cccaattcca tgcctttatt atcacaaggg aggatggctc    600
 tcggacattt gggtttgccc tcacatttta tgaagaggtg actagcaagc agatctgcag    660
 tgcaatgcag accctctacc acatgcacaa tgctgagtat gatgtcctac atgctccccc    720
 tgctgatgac agagaccaga gcagcatgga ggatggtgaa gacactcctg tgaccaaact    780
 gcagcgcttc aactcctatg acattagccg ggacactctc tacgtctcta agtgcatctg    840
 cctcatcaca cccatgtctt tcatgaaggc atgtcggagc gtgctggagc aactccacca    900
 ggcagtcact tcacctcagc cccctccact gccccttgag agctacatat acaacgtact    960
 ctacgaggtg ccgctcccac ctcctggccg gtccttgaag ttttctgggg tctatgggcc   1020
 aataatctgc cagagaccaa gtaccaatga gcttccccta tttgactttc ctgtcaaaga   1080
 ggtttttgaa ctgctcgggg tggagaatgt gtttcagctt tttacttgtg cccttctgga   1140
 gtttcaaatc ctgctctact cacagcatta ccagagactg atgactgtgg cggagacgat   1200
 tacagctctc atgtttcctt tccagtggca gcatgtctat gtccctattc tcccagcttc   1260
 tctcctgcat ttcttagatg ctcctgttcc atacctgatg ggtttgcatt ccaatggcct   1320
 ggatgaccgg tcaaagctgg agctgcctca agaggctaac ctctgctttg tggacattga   1380
 caaccacttc attgagttgc cagaggactt gccacagttc cccaacaaat tggagtttgt   1440
 ccaggaagtc tctgagattc tcatggcatt tggaattccc cctgaaggga atcttcattg   1500
 cagtgagagt gcctccaagc tgaagaggct gcgggcctct gagcttgtct cggacaagag   1560
 gaatgggaac attgctggct cccctttgca ttcctacgag cttcttaagg agaatgaaac   1620
 tattgcccgg ctgcaagcct tggtcaagag aactggggtg agcctggaaa agttggaagt   1680
 gcgtgaagac cccagcagca ataaggatct caaagttcag tgtgatgaag aagaactcag   1740
 gatttaccag ctaaacattc agatccggga agtttttgca aatcgtttca ctcagatgtt   1800
 tgcagattat gaggtgtttg tcatccaacc cagccaggat aaggaatcct ggtttaccaa   1860
 cagggagcaa atgcaaaact ttgataaagc atcttttctg tcagatcagc ctgagcccta   1920
 cctgcccttc ctctcaagat tcctggagac ccagatgttt gcatctttca ttgacaacaa   1980
 aataatgtgt catgatgatg atgataaaga ccctgtactc cgggtatttg attcccgagt   2040
 tgacaagatc aggctgttga atgttcggac acctactctc cgtacatcca tgtaccagaa   2100
 gtgtaccact gtggatgaag cagagaaagc aattgagctg cgtctggcaa aaattgacca   2160
 tactgcaatt cacccacatt tacttgacat gaagattgga caagggaaat atgagccggg   2220
 cttcttccct aagctgcagt ctgatgtact ttccactggg ccagccagca acaagtggac   2280
 gaaaaggaat gcccctgccc agtggaggcg gaaagatcgg cagaagcagc acacagaaca   2340
 cctgcgttta gataatgacc agagggagaa gtacatccag gaagccagga ctatgggcag   2400
 cactatccgc cagcccaaac tgtccaacct ctctccatca gtgattgccc agaccaattg   2460
 gaagtttgta gagggcctgc tgaaggaatg ccgcaataag accaagagga tgctggtgga   2520
 aaagatgggc cgagaagctg tggagctagg gcatggggag gtgaacatca caggggtgga   2580
 agagaacacc ctgattgcca gcctttgtga tctcctggaa aggatctgga gtcatggact   2640
 acaagtgaaa caggggaaat cagccttatg gtcccacctg ttacattatc aggacaaccg   2700
 gcagagaaaa ctcacatcag gaagcctcag tacctcagga atacttcttg attcagaacg   2760
 taggaagtct gatgccagct cactcatgcc tcccctgagg atctccctga ttcaggatat   2820
 gaggcacatc cagaacatcg gggaaatcaa gactgatgtg ggaaaggcca gagcatgggt   2880
 gcgactgtcc atggaaaaaa agttactttc cagacacctg aagcagctcc tctcagacca   2940
 tgagctcacc aaaaagttat ataagcgcta tgccttcctg cgctgtgatg acgagaagga   3000
 gcagttcctc tatcacctcc tgtctttcaa tgccgtcgat tacttttgct tcaccaatgt   3060
 cttcacaact atcctgatcc cgtaccacat tctgatcgta ccaagcaaga agctgggggg   3120
 ctccatgttc actgccaacc catggatctg tatatcagga gaattgggtg agacacagat   3180
 catgcagatt cccaggaatg tgctagagat gaccttcgag tgccagaact tggggaagct   3240
 tactactgtc cagattggcc atgataactc tgggctgtat gccaaatggc tggtggagta   3300
 tgtgatggtc aggaatgaga tcacaggaca tacctacaag ttcccgtgtg gccggtggtt   3360
 agggaagggc atggatgatg gaagcctgga gcggatccta gttggggagc tgctcacatc   3420
 ccagcctgag gtggatgaga ggccatgccg gaccccgccg ctgcagcagt cccccagtgt   3480
 catccggagg cttgttacca tctcacccaa caacaagccc aagctgaaca ctgggcagat   3540
 ccaggagtcc atcggggagg cagtcaatgg cattgtgaag cacttccata agcctgagaa   3600
 agagcgaggc agtctgacgc tgttgctctg tggagagtgt ggccttgtct cggccttgga   3660
 acaggctttc cagcatggat ttaaatcgcc ccggctcttc aaaaatgtct tcatttggga   3720
 tttcctggaa aaagcacaaa cctattatga gacattagag aagaatgaag tagtccctga   3780
 ggaaaactgg catacaagag cccggaactt ctgccgattt gtcactgcaa tcaacaatac   3840
 tccccggaac atcggcaagg atggcaagtt tcagatgctg gtgtgcttgg gagccagaga   3900
 tcacctccta caccactgga ttgccctgct ggctgactgc cccatcactg cacacatgta   3960
 tgaggatgtg gcactgatca aagaccatac acttgtcaat tccttgattc gtgtgctgca   4020
 gacattgcag ggagtttcaa catcacgctg ggaggacgtc cctttgtcaa ggggcattcg   4080
 gacatcttga cctcccagca ccagcccggc agcagggatt gaggaaagac tcaccctggc   4140
 agctctgacc tttttttccc aaaggggact taaggcgatt gtgcaggagt aggagacaaa   4200
 atgttacact cactgtaaaa agaaaactag gaggattttt gggaataaat aatctatttt   4260
 agagtttatt tgctgatttg ctttttacac actttcatgt gaaagagtga tagggagagg   4320
 gagcgaggct ggtgccgctt attttgaagc tggtgccctc cctcgccgtg gccacatgct   4380
 ggaagcctga ggcctccctg gactgagcct gtggcactgc gtgcgggaca gttatgtttc   4440
 cttgccccgt cgcattaatg aggcccttcc acatcatttt taaactaatg tttttctata   4500
 ttaacattat tatggatatt tggctttcat aggccacaca caggtggtct gccgcgggaa   4560
 gcccccaggc ccccaatcaa agggattttt tagtagtgcc ctcctaagca agcaccgaat   4620
 gagtcagtcc ccacgtattt tccttttttg tccagtattg tttgggaagg agacatgccc   4680
 gggatgtgtc catccgtgcc caaataccca catttccctg ttggccacag tttccacaga   4740
 agtaaacata agcatgtttt aacaggtttt tccttttctt ttttcttttt taaaatgttt   4800
 tatttattta acccgccatt gtgtgttttt aagtattttc tttttttaag ggaaaggaaa   4860
 agcttgtcac aatctaactg gctatgttat tattattaaa tttatgtttt gcaacttaga   4920
 aaccagctac agtatggccc acttaataaa acacctcaaa caaaaaaaaa aaaaa        4975



      <210> 647
      <211> 657
      <212> DNA
      <213> Homo sapiens


      <400> 647
 taccgaacag atttgcttgg tgtgtcttac ttgtggctat tcatttattc tcaccaggga     60
 cttccttcgc tgggcatctg gctgggattc ttgttggact aatgtacact caagggcctc    120
 tgaagaaaat catggaagca tgtgcaggcg gtttttcctt cagtgttggt tacccaggac    180
 ggcaatacta ctttaatagt tcaggcagct ctggatatca ggattattat ccgcatggca    240
 ggccagatca ctatgaagaa gcacccagga actatgacac gtacacagca ggactgagtg    300
 aagaagaaca gctcgagaga gcattacaag ccagcctctg ggaccgagga aataccagaa    360
 atagcccacc accctacggg tttcatctct caccagaaga aatgaggaga cagcggcttc    420
 acagattcga tagccagtga ggtggcatct tgggaagaca tggcctattc gtgtaattat    480
 tgcccatttg gctcattccc caagccccta attcatttta attcatttta aacaaaagca    540
 gagtacaccg gtattgctcc agatcgctca catcacctgg gacagtccca tggcccctat    600
 gagtcaactc acagcttgcg gggagtgggc cttctcctgg ccttgttctt gctcata       657



      <210> 648
      <211> 1784
      <212> DNA
      <213> Homo sapiens


      <400> 648
 tccccacctg aacctgtggt taccaatgct atgcgagaag acctggcgga tatctgttac     60
 atcagggctg tgaccgtcta cgacaagccc gcatctttct ttaaagagac acctctggac    120
 ctgcagcacc ggctcttcat gaagctgggc agcatgcact ctccgttcag ggcccgctca    180
 gaacctgagg acccagtcac ggagcggtcg gccttcacgg agcgggatgc tgggagcggg    240
 ctggtgacgc gtctccgtga gcggccagcc ctgctggtca gcagcacgag ctggacagag    300
 gacgaagact tctccatcct gctggcagct ttagaaagta gagtttgaac aactgactct    360
 tgatggacac aaccttcctt ctctcgtctg tgtgataaca ggcaaagggc ctctgaggga    420
 gtattatagc cgcctcatcc accagaagca cttccagcac atccaggtct gcaccccctg    480
 gctggaggcc gaggactacc ccctgcttct agggtcggcg gacctgggtg tctgtctgca    540
 cacgtcctcc agtggcctgg acctgcccat gaaggtggtg gacatgtttg ggtgctgttt    600
 gcctgtgtgt gctgtgaact tcaagtgttt acatgagctg gtgaaacatg aagaaaatgg    660
 cctggtcttt gaggactcag aggaactggc agctcagctg cagatgcttt tctcaaactt    720
 tcctgatcct gcgggcaagc taaaccagtt ccggaagaac ctgcgggagt cgcagcagct    780
 ccgatgggat gagagctggg tgcagactgt gctccctttg gttatggaca cataactcct    840
 gggccagagg ctaaaacccc aggacccctg ctgtccttcc cgcagcttct tcttggagtc    900
 tcagggcaaa ccctttcgag cagcacctcc cagtggccag aagctgaaat gacagcagtg    960
 gtactgcctg gtaaaagaat tggttctgtg acccgggaag ctttggttgg ccttgatttc   1020
 ttctctggag gcttggaaac gcttcctctc ttcttctgtt cttcacgccc catgcccctg   1080
 ctagcgtatt actgttctgt gacttccctg tgacctctgc agaactcctc atcctgcgtt   1140
 tggtctccag gtgtcccctt tctgccgtgt tcctaacatt ttgattcctg tcttgaaaaa   1200
 agcacctgct gcaccgtaag cccagggatg tggcagctgc agtgggcttg gctttgtgag   1260
 gaactgagtg tgtccacgtt gggggaacat catacttgat acacacgttt ttatttgcac   1320
 aaagaaaatg ctgtttttgg agccagaatt ttcatgtctg atttatggtg attttcttaa   1380
 gaaccagaac tgctggcaga aagggggcac ccacacgctt agatagccga tgtcttatta   1440
 gagggcagtt tgtggttcct gatttggaaa ttaacattct ccaaacattc cagtccaatg   1500
 aaagttttat ccgctttccc atataaaaat tcttcccatg agagtgactt gattctcaca   1560
 atcccgttgg agtcgtgtgt gagtcctaca gggtgagatt cagcattgcc atctccaagt   1620
 gctcttcgta gggaaacagt ttctgctcat gacgaggttc cacttcccat ctgatcccgg   1680
 cccggcctaa cttcgtggtg aacagctggc acgtctctgg gttgcggacg gtaaaggcca   1740
 cgtagacctc aggagcccgc tggtgctccc ggcaggcagc cagc                    1784



      <210> 649
      <211> 404
      <212> DNA
      <213> Homo sapiens


      <400> 649
 aaatgagcca tcattgtcat cgaaaaggaa aatgtgtgaa atggccacca gtggtgacag     60
 acaaagagac tcagaagtta atttcaagga actgagaaca gcaaaaatga aacctgaact    120
 actgagtgga cacatccccc caggccacat tcctaaacct atcgtgatgc ccgactatgt    180
 ggcaaaatac cctgtgattc agacagatga tgagcgagaa cgctataaag ctgtgttcca    240
 agaccagttt tcagagtaca aagagctgtc tgcagaagtt caggctgtcc tgaggaagtt    300
 tgatgagctg gatgcagtga tgagcagatt gccacatcat tcggaaagcc gacaggaaca    360
 tgagagaatt tcaagaatcc atgaagagtt taagaaaaaa aaaa                     404



      <210> 650
      <211> 931
      <212> DNA
      <213> Homo sapiens


      <400> 650
 ggcacgagga agccagttta caaacatccg ctggtctttg ttttgctggc tgtacttgtg     60
 ctttcagtaa ctacacagat taactatctc aacaaggcac tggacacctt taatacctct    120
 cttgtgacac ccatttatta tgtattcttc acatccatgg tagtgacttg ctctgccatc    180
 ttattccaag agtggtatgg catgacagct ggagatatca ttgggaccct gagtggattc    240
 ttcactatta tcattggcat cttccttcta catgctttta aaaatactga cattacttgg    300
 agtgagctta catccactgc taagaaagaa gccgtctctc tgaatgtcaa tgaaaacaat    360
 tatgttttac tagagaactt ggagtgttca gccccaggat acaatgatga cgttaccttg    420
 tttagtagaa ctgatgactg aagtctctag aaacactgag ttttaaccaa tatgagacac    480
 acgaagagga aaatgaatgc ttgcttcttg gaagaactgc taggaaagtt agcatttttg    540
 cagttctaac taatttagat gtgaggccaa gtaaaaatgc catttttttg gccattgaat    600
 ttgaaaatca aattgattat cctccagaat ctctacaaac tttgaaatac tctctaagga    660
 tcaaagaagt caaagagcta tgtgtgtctc agaataatct ccttcttctg gtcacagtat    720
 ctttgtctct gccaggtggc tcttcatttc tttggtagct atttttagac cttacagtca    780
 ttcaccaata tacagttagc agtgttctga tagacacagt atcagtcata ttctccgttg    840
 gagtcataat ttcaaactca acaagatttc agaaaggtat aatcatggta atttctcata    900
 ttaaaactgg agaagagagg ccaggcatgg t                                   931



      <210> 651
      <211> 375
      <212> DNA
      <213> Homo sapiens


      <400> 651
 ttttttaagc aattttccaa attttcagca tgatattaat atttcttcat caaatgaaat     60
 catttcttcc cggggcttca ttcagacaac agatgtttct tcctcagcca aaaagaaaat    120
 attgttattc caattacgac gcatagctga agactgtcaa attcccctaa tggtgtataa    180
 ccaggcattt atatattttg atcagtatgc tgcaatatta gaagacactg ttagaaatgt    240
 attggttgca tcagcagcta tgttcattgt ttccttattg ttaatccctt atccattgtg    300
 ttccttgtgg gtgacttttg ctatcggttc tgtgattgta ggggtaacgg gtttcatggc    360
 attctggaaa gtcaa                                                     375



      <210> 652
      <211> 1575
      <212> DNA
      <213> Homo sapiens


      <400> 652
 atgagaagcc cctgtgtcaa caagatccag gggctggagc ccaatgccaa gcctgtgttg     60
 tccccagcga ccctgcagct gctcgctctg atgtaccctg tgccattcaa ggaaatgtgg    120
 tccaggaaag gtaatgctta caccgctgat agtggtgctg aaaactatca atcacttatt    180
 gctggatcgt gcgacaccag aggtctggga tacgttggcg gcgtagcatt tggcatgatg    240
 actacgggta ataatgaatg gcccagggca caaatatcag taggcactca agatagggat    300
 ggatcaggca atattggtct gcaaatgcat ttcaggttta tggcttcagg gcaaatatct    360
 tacgctggac cgcaaggggc tggaagtttc caacaggttc cggcatctga cagaaatata    420
 aagcacagca taaaggatga tgaatcaagc attgcataca acaacataaa atcaatgaga    480
 tttaggaact ttatatttaa cgatgatgag caagaaaggc ttggagctcg gcggcacaac    540
 cagcaccatc tggtcgcgat ggtggacacg gaaagcccac tctgccccct ctccccactc    600
 gaggccggcg atctagagag cccgttatct gaagagttcc tgcaagaaat gggaaacatc    660
 caagagattt cgcaatccat cggcgaggat agttctggaa gctttggctt tacggaatac    720
 cagtatttag gaagctgtcc tggctcagat ggctcggtca tcacggggag cattcaacaa    780
 acagcagcag tagaaaaaga agagtatggg gcagcagcaa cagaagggca tgtggccctc    840
 ctgggccctt cctccacaat tcacaacaaa atcacaaacc gcacccatga ctggggtgcc    900
 ctggccctgg atggcggccc tgtccctcgg tgctcaggct gccgggttca agtggtgggc    960
 tggctttgca tccctcctag gaaggccaag tgcttgacac agcgtgaaca ctatcccttt   1020
 tataaggtta tcaacacagg atgccaggtt cctcacctga agaagaacct tgatcacctc   1080
 ctggggatgg gctcttctcg agcatggctt ccaagtaccc agattcacag gtggagaggg   1140
 gctgctggag gcccccggac ctcacgcttc ctgagggcca ccccggagcg gctgcagccg   1200
 ctggcggcac cgggaaaagc atctcggcca atgtggcccc gtcccagagc accacccgag   1260
 acatcaggag cccatcgtgg gctagggaag atcctccggg acctaacggc ccagggaagg   1320
 actcactcca gtcacaagca gctggagatg gatggtttgg cagagaaggg gaaccccagc   1380
 accaacccag ccccaggccc caccttgcag caggtctgcc cttgccagag tcctcgaggg   1440
 gctcagcctg accctgacag gtggcctggg ggcacccaag gcttcgggca gcccctgagc   1500
 tgggcccagg tctcatggcg gtctcagggc aggcagggtc ttccaccctt ggccacctac   1560
 ccaggtgatg cctga                                                    1575



      <210> 653
      <211> 1420
      <212> DNA
      <213> Homo sapiens


      <400> 653
 gagctgggag gctgcgagat ccctaccgca gtagccgcct ctgccgccgc ggagcttccc     60
 gaacctcttc agccgcccgg agccgctccc ggagcccggc cgtagaggct gcaatcgcag    120
 ccgggagccc gcagcccgcg ccccgagccc gccgccgccc tttgagggcg ccccaggccg    180
 cgccatggtg aaggtgacgt tcaactccgc tctggcccag aaggaggcca agaaggacga    240
 gcccaagagc ggcgaggagg cgctcatcat cccccccgac gccgtcgcgg tggactgcaa    300
 ggacccagat gatgtggtac cagttggcca aagaagagcc tggtgttggt gcatgtgctt    360
 tggactagca tttatgcttg caggtgttat tctaggagga gcatacttgt acaaatattt    420
 tgcacttcaa ccagatgacg tgtactactg tggaataaag tacatcaaag atgatgtcat    480
 cttaaatgag ccctctgcag atgccccagc tgctctctac cagacaattg aagaaaatat    540
 taaaatcttt gaagaagaag aagttgaatt tatcagtgtg cctgtcccag agtttgcaga    600
 tagtgatcct gccaacattg ttcatgactt taacaagaaa cttacagcct atttagatct    660
 taacctggat aagtgctatg tgatccctct gaacacttcc attgttatgc cacccagaaa    720
 cctactggag ttacttatta acatcaaggc tggaacctat ttgcctcagt cctatctgat    780
 tcatgagcac atggttatta ctgatcgcat tgaaaacatt gatcacctgg gtttctttat    840
 ttatcgactg tgtcatgaca aggaaactta caaactgcaa cgcagagaaa ctattaaagg    900
 tattcagaaa cgtgaagcca gcaattgttt cgcaattcgg cattttgaaa acaaatttgc    960
 cgtggaaact ttaatttgtt cttgaacagt caagaaaaac attattgagg aaaattaata   1020
 tcacagcata accccaccct ttacattttg tgcagtgatt attttttaaa gtcttctttc   1080
 atgtaagtag caaacagggc tttactatct tttcatctca ttaattcaat taaaaccatt   1140
 accttaaaat ttttttcttt cgaagtgtgg tgtcttttat atttgaatta gtaactgtat   1200
 gaagtcatag ataatagtac atgtcacctt aggtagtagg aagaattaca atttctttaa   1260
 atcatttatc tggattttta tgttttatta gcattttcaa gaagacggat tatctagaga   1320
 ataatcatat atatgcatac gtaaaaatgg accacagtga cttatttgta gttgttagtt   1380
 gccctgctac ctagtttgtt agtgcatttg agcacacatt                         1420



      <210> 654
      <211> 5597
      <212> DNA
      <213> Homo sapiens


      <400> 654
 aatcttggct gttctccagg gttttttttt tgtgttaatg ctttaatatg tggaccaagt     60
 gacacacatt acagaatctc cccttccctc tgtctcttac agttttgcgt ttggctccct    120
 aatatctgct gtcgatccag tggccactat tgccattttc aatgcacttc atgtggaccc    180
 cgtgctcaac atgctggtct ttggagaaag tattctcaac gatgcagtct ccattgttct    240
 gaccaacaca gctgaaggtt taacaagaaa aaatatgtca gatgtcagtg ggtggcaaac    300
 atttttacaa gcccttgact acttcctcaa aatgttcttt ggctctgcag cgctcggcac    360
 tctcactggc ttaatttctg cattagtgct gaagcatatt gacttgagga aaacgccttc    420
 cttggagttt ggcatgatga tcatttttgc ttatctgcct tatgggcttg cagaaggaat    480
 ctcactctca ggcatcatgg ccatcctgtt ctcaggcatc gtgatgtccc actacacgca    540
 ccataacctc tccccagtca cccagatcct catgcagcag accctccgca ccgtggcctt    600
 cttatgtgaa acatgtgtgt ttgcatttct tggcctgtcc atttttagtt ttcctcacaa    660
 gtttgaaatt tcctttgtca tctggtgcat agtgcttgta ctatttggca gagcggtaaa    720
 cattttccct ctttcctacc tcctgaattt cttccgggat cataaaatca caccgaagat    780
 gatgttcatc atgtggttta gtggcctgcg gggagccatc ccctatgccc tgagcctaca    840
 cctggacctg gagcccatgg agaagcggca gctcatcggc accaccacca tcgtcatcgt    900
 gctcttcacc atcctgctgc tgggcggcag caccatgccc ctcattcgcc tcatggacat    960
 cgaggacgcc aaggcacacc gcaggaacaa gaaggacgtc aacctcagca agactgagaa   1020
 gatgggcaac actgtggagt cggagcacct gtcggagctc acggaggagg agtacgaggc   1080
 ccactacatc aggcggcagg accttaaggg cttcgtgtgg ctggacgcca agtacctgaa   1140
 ccccttcttc actcggaggc tgacgcagga ggacctgcac cacgggcgca tccagatgaa   1200
 aactctcacc aacaagtggt acgaggaggt acgccagggc ccctccggct ccgaggacga   1260
 cgagcaggag ctgctctgac gccaggtgcc aaggcttcag gcaggcaggc ccaggatggg   1320
 cgtttgctgc gcacagacac tcagcagggg cctcgcagag atgcgtgcat ccagcagccc   1380
 cttcaagaca taagagggcg gggcgaggta ctggctgcag agtcgcctta gtccagaacc   1440
 tgacaggcct ctggagccag gcgacttctt gggaaactgt catctcccga ctcctccctg   1500
 agccagcctc cgctcagtgt ggctcctcag cccacagagg ggagggagca tggggccagg   1560
 tgccagtcat ctgtgaagct agggcgccta cccccccacc cggaggaccc ctgcggcccc   1620
 ctgcctagag gagcaccatc tacagttgtg ccattcccca gccactgcct tcatgctgcc   1680
 cccgccggac tggcagagcc agggggtcag ccacctgcct ttgagtcatc aagatgcctc   1740
 tgcagccaca attctgacct aagtggcagg gcccagaaat cctgaaaacc tcccgctgcc   1800
 ttttgtgata cttcctgtgc tccctcagag agaaacggag tgaccttttg tcctttacct   1860
 gattggcact tcgcagtcta tctccctggg tagcagacgg ctgctgccct tctctgggca   1920
 tgttctgaat gtttacactg gtaccttctg gtatcttctt tagagccccc tgcaagctgc   1980
 aactctaggc ttttatcttg cggggtcaga gcgccctcta gagggaaaag ctagaggcac   2040
 agggtttctg ccggcccaca actgctgtct tgatttgcat tttacagcaa agtgctgaga   2100
 gcctctagtc gcctcctgcc atctgatctc cctccccacc attcccgtac tcagttgttc   2160
 ttttgtctaa tcggaggcca ctgtgctgag gccctgcagt gtctgctcac tgctgccatc   2220
 ttcgctgcta gtcagggttc catcctcttt cccctctccc agttccctac cacgttggat   2280
 cccattcgtc acccatgcta gggtccccaa agcactgggg caggggccag agcagcagca   2340
 cccagagctc cctcctctac tctgacctgg ggccccagca tcctggagca cacgctccac   2400
 gcacacacac cccagccctg tcccaggggc ctggccccct cagccatctc agggtgagga   2460
 gctgccagtc atgtccagat ggaatgactc ccatcctctc ctcatctccc ctttgacgag   2520
 cctcaaactg ctcagctcat caaagagcca ttgccaactt ccgtatgtgg ttctgggtcc   2580
 cagggagcct tggaacctgg caccctgggg tggtttaatt catcattaag aagcattcct   2640
 gcttctcaag ggacacagtg gcctgcatgg gccagcatgg accctgggct gatcatgtgc   2700
 attcctgctt ctctggggac acagtgggcc cacatgggcc agcatggacc ctgggctaga   2760
 gcaagcacat ctccatctct tccacctcag gcagtgtggc tccagatgtc aggagggact   2820
 gacctcagga ccttccaggt tcctctgtgc caggaatgag aggccaggcc cgatcctacc   2880
 acctcgcctt gaccctgaag tcagagcagg ccagccaagc aggaagcaca ctgtttactt   2940
 tttgcatgaa aagtaaatgt gtacttgata gagctaaaat atgatctttt ttaatttctc   3000
 aaccccataa tttgagccat tgccttgctt aattttggtt tccaccattt ccttttagtg   3060
 gagaagagag gaagtcagag ggtagggacc tttgcctgcc cctgggcgag tgcgggcagg   3120
 gatctgagac cagattgttc tcgcacccct gccagaactc actctcccct gaagtttagg   3180
 gtcccatctc ccagatgtaa gttgttttgc aaactcagtt tgccaggatt tctttctttc   3240
 ctaatcttaa attcacagat aaagcaatga aaagagtcag atcccatttc cgtctgcccc   3300
 ctcgtcacca ggtgtgatag ccccagccag gtcacacctg gcctcacact ttgagctgag   3360
 acttgaaaac gatgctgtgg cggaagagca tgtggggctt ggtggagggg ccccaggatt   3420
 tgttgggggc aaagggggtg gcgggaccgt tcccaggagg taccagcacc tgcctcgatc   3480
 tcctctgagc ctcttctgcc ccctgtcggc caggtgaggt cagcagcctg ggagagtgcc   3540
 cccaagagat gagggcaccc cgtgttcctt ggcaatcttg gctcaccttg gtaacaaaag   3600
 gccatagaag tctgtttttc tgggtcagtt ttttttgcct gagaataaca aattgctgct   3660
 gtctaccttt agcacaccca ataattctat ttggggcagt gaatgcatag aagatataaa   3720
 aatacgcagc ttaactatat cttcctgcgt gtgtatttat tttcttctgg gtctaggcca   3780
 tggtacagga gaactgtggc gtgtaggagg aatacttcag gatgagtgaa ggctggagcc   3840
 agggagcgct ggaggaaacc agccctttag ccagcagccc ctccaccaca ggcactgctg   3900
 tgtggaacga gttcttggaa tgaatcccat gctttctgca gcctgtagtt gttatgaccc   3960
 ctcggaacaa ccaccccgtg gcttgtgtgg ggtctcgcag ggaaaagggc tggcttctag   4020
 gtccccgaga taagtgtgca gggggatggg ccagggccag gctaagggtg gctcagttcc   4080
 atcatctgga ggtcagacac actgtccaga ggcagaactg aagccctctc ggcccctacc   4140
 ctaagccagc cacccctctt cacagtgggt gagctgggct gggctggctg gcatgaggcc   4200
 aaggggtagg cctgagcgcc agagtcgccc aggttagccc acaggattcc tttgtgtgcc   4260
 atggaatgct gaaagatggg tgactgggga cccttcttaa aacctttggc aaaggtgcca   4320
 tcggcagggc ttggcctcat gaagtctcag gtccgtgttc ccgcagggcg cacatgcttg   4380
 gagagtcctc agcagggtag ccgaggccag gccacttctg ctgaggatgg ggcaggctgg   4440
 ggtgtgggtg tggcctgggg tggctcaggt ctggaactgc tgcctgattc ctgtgtgggg   4500
 agaagctcag tggccgtttg ctgccactga caaggatttc acatgcagaa gagaaaaggc   4560
 ccccctccac cccccgcatt ccctgccgag tgagagccag tgtttgctgc ccttgctggg   4620
 ggcgggtagg aaaccctgag cttcctgatg cggagtcatg aagcagagtc ctcgggaagg   4680
 catctccaca gccccgggtc ctctgtctaa cgccctccat ttcacgccct ccatctcaca   4740
 gtcaagataa aggcctcgag aataaagagc cagccccctt ccatttagtc tcctgccgtt   4800
 tcccaaacag ttgtccaaca gttagacatt gaggggcttc actgttacca ggcatgtaac   4860
 agaaggagga agactaacac acaccccctg ccccatccca tccccctctc ccgagctatt   4920
 ttcttgctgt ggcctctggt gcccttgagt tggtctcccc ggctgctctg cgggggcttc   4980
 actggcttcg gagtgagcgc gaagtgctgg tgagcagtgg gcctgtgatt ggatgggaag   5040
 atgtgcatcc gtggtcaaaa gtcagctgcc agccctgcgg aaccagagcc tcaggctggg   5100
 atgggggagg cctccctgct ttcacctgca tggggggcat ggcctggctt acaccaaagg   5160
 ctttgacggt ttctccaagt aaggatctgc aaatcttgaa tcgtcctcaa aatgacgaag   5220
 cttgaattgt cctcaagatg gatgtgaatc ttacattcct tttcatcatt tcctttgtaa   5280
 aaatgacgag tgcctgggtt tttgttttaa gaagcattat gaaggccaga cttactcatt   5340
 tttctccccc aagtgagctg caagaggccc ctgttaggcc cctgtttcct gagcagtgat   5400
 gtgctgctct tcttggtggg gctttgggct gggaggggaa ggcgggtcag agatggggga   5460
 cctgtggctg ccatgcagga gcccctgcgt catctcgttg gactctttaa gggagtcagg   5520
 aatagatgta tgaacagtcg tgtcactgga tgcctattta gaaataaagt gtatgctgct   5580
 gaattggaaa aaaaaaa                                                  5597



      <210> 655
      <211> 1117
      <212> DNA
      <213> Homo sapiens


      <400> 655
 atttgagggc aacgtgttta tgtattatgg actgtctaat ttctatcaaa accatcgtcg     60
 ttacgtgaaa tctcgagatg atagtcaact aaatggagat tctagtgctt tgcttaatcc    120
 cagtaaggaa tgtgaacctt atcgaagaaa tgaagacaaa ccaattgctc cttgtggagc    180
 tattgccaac agcatgttta atgatacatt agaattgttt ctcattggca atgattctta    240
 tcctatacct atcgctttga aaaagaaagg tattgcttgg tggacagata aaaatgtgaa    300
 attcagaaat ccccctggag gagacaacct ggaagaacga tttaaaggta caacaaagcc    360
 tgtgaactgg cttaaaccag tttacatgct ggattctgac ccagataata atggattcat    420
 aaatgaggat tttattgttt ggatgcgtac tgcagcatta cctacttttc gcaagttgta    480
 tcgtcttata gaaaggaaaa gtgatttaca tccaacatta ccagctggcc gatactcttt    540
 gaatgtcaca tacaattacc ctgtacatta ttttgatgga cgaaaacgga tgatcttgag    600
 cactatttca tggatgggag gaaaaaatcc atttttgggg attgcttaca tcgctgttgg    660
 atccatctcc ttccttctgg gagttgtact gctagtaatt aatcataaat atagaaacag    720
 tagtaataca gctgacatta ccatttaatt ttatattatg aaagcaaatc atctgcatgt    780
 gcatcaaggc cagtcctatt caacctagct ttcgaatgct gatatctggt tagtatgtca    840
 ttttgaaggg ggcacataac ttttctaaaa aaaagcagtc tttgttgttt gcttcttccc    900
 tacggatgac ttctaaaaat atatgacggg tataaaaaaa ttagctatat tgatcatatc    960
 aacactgtaa ctgctgaaat ggcattctaa tgtttgcttt ttattcggac aggccacatg   1020
 atgcatagag cctctttcat gtgacttgtg tctactgctt aaatctttat gctgtgttga   1080
 tgatattata ttgacatatg aagctgtaaa aaaaaaa                            1117



      <210> 656
      <211> 1353
      <212> DNA
      <213> Homo sapiens


      <400> 656
 gctaaaaatt taccaaaata gtttgaacac ataaaaatat ttttaaaaaa acagaaccaa     60
 aaacccagca taaatttagt tgtataggca ttggttagag gacactgttt tcactaagga    120
 ttatattcaa caactttctc ttgagttgtt actaaaattc tgattctgaa ccttatagct    180
 tataatggtg ccaactatta gaaatgggac cctctaattc agtccaatcg caacatgtat    240
 tatgatataa tagatgaagg gtatgtctac actataataa aaaataaaca tatttttggt    300
 tatttaaaga ccatcttcct aacctgtaac taaaataact gtatttgatt taaacttatt    360
 taagtgcagt gaattatgga aagctaactt aaaggtttga ataatcaatt atgagtaagg    420
 aacacctgtt gacagccccg tgacccttca gaaccaggca tttgctgaaa aaaagaaatc    480
 actagcattg aatatagccc ttagtcacat gagagattaa cttcatgagc aacccagcat    540
 gtagaggatg aggtggactt tcccagccac ccactccttg aggggacagt agtattcata    600
 gtgaaactgc tcaaactctg gtgtctggcg gatttcgcat aagaaggaga gatcaatacc    660
 tgactccaaa aggaggagga gcaggggaaa tacaaagagc agcagtccca ggcccaccac    720
 aaggagcctg gaaaaactct tgaccagtgg gtcaccccga atatggccag tcagaatgtc    780
 gtagctccac gacaaagcac ggcgagcctc cttcagctcc tcttcttcag caatcaaaaa    840
 ggcgttttca tctgcttcca gatcctcaaa tgaatctgtg tcttctcttt ccaactcaag    900
 cctagaagga cagtcaaaga gcatgtcaat ctcatcgtca tccacagggg tggggagcag    960
 gctggcactt gggttgtaca ctagttcaga gatggttaaa ggttcttctt ttattttatc   1020
 ttcctcttca ctagggggat cttcatactc ccgggctgcc ttcactgggg agctggagat   1080
 caagggagca gaaatgttct cctctttagg caatggaaca ccagtgttac gagctgtgac   1140
 cttggagccg agtctcagca gacgaacaaa cacattactg ttgcagtggt tccccatgtg   1200
 caattggagg cttcgtcgag tctggatcta gaccaagcat tatgccatac tggttattcc   1260
 aatcccctat ggtctcctcg gcctgcatgg cccagggcag cctttcccta acagtccatt   1320
 ctgttataaa ggacctaggc acccacgcgt ccg                                1353



      <210> 657
      <211> 1299
      <212> DNA
      <213> Homo sapiens


      <400> 657
 aggaattcta cattaaaaaa aagctaaatg tcttcactga agctttgcat ctctctgtaa     60
 aaatgacgat ttggttcagt gaagacactg agtgattcga tgtccatgac tgcatgccaa    120
 ggttgaccca ggcccaggga tacctgctca ataaggttat gcactggatc tacatcctgg    180
 tcggccagtt caccttggtc aaaatcaatg ctttcttcgg tgacttcaag cactttcaga    240
 tcagagcccc gaagacgagc aatggcaatg agattgtgtg cccacaccgt gtaaccatga    300
 attgccagaa gagagagctt tgtgcacctc catgctaata aaaccaacgg atcttcattt    360
 cggttgtcac taagatctgg aaaaccagat gtgtcaatca catcattcat taaaataaaa    420
 tgagtgagga acttgtcata ttgcctggat ataagatcaa caatagcccc tgaaacacaa    480
 gtgatatagc tatcaaaatg aatcctctct agtggtatac tgggtttcag aatctttaac    540
 atatcttcac tcttgatatc aaaagccatt atatagaccc gaaagctggt gctctttcgt    600
 gacagggctt tccaatgctc atcatttggc atgttgtcca gagacttgtg cattacagaa    660
 acattgtgaa ccagaagaga cagtcgttgc aaaggcacat ggttgctatc agttaagact    720
 cttgccatct cagctgtaaa gtcacaaaaa tccaaggcaa gtgagtgcag attcacaaat    780
 cgctccagtt caactgcagt aataagagtg ctgttaccag gaatattatt gtccagtaaa    840
 ctgaggtgct ccatggtgtt ggcaacagca ttagagagag atgacagtga tgttggggtt    900
 actatttcca gcataaaccc acaggacagc catttcagtt gcctactatt actcaggatt    960
 tcttcaaaca gttgctgaat ttgtttaatt tttttgccat cagggtccac cttgctgagg   1020
 tatgtatttg acaaacttcc ttgctgttgt agaacactta tgtctccaaa aagactaaac   1080
 ttctgaaggt tcctgttgtt ccggatgctg accagcacgc aaagcaccag ctccaagtag   1140
 gtgcgcagca cttccagcca acgagctgag agctgcaggg cctcgacttc ctcccctcca   1200
 gtcccggtgt ccgcgccacc tccgtcccct gggccaccgc cgctcagata gttctcggcg   1260
 gcgaattcaa cacgcagctc tcgcacgaac cagccgcac                          1299



      <210> 658
      <211> 492
      <212> DNA
      <213> Homo sapiens


      <400> 658
 tttcgtcggg cctcgggtgc gcgggcacgc gggactccca gctgtcaatc aggcgcgggc     60
 tgagctctac gaggcggagc ggcggcggtg gcgacggcga tgggacccca gcgagagatc    120
 tgcagctagg ctggctgcac ttgctccacg ggtcagggga tcggaggggg attgaagaat    180
 gcgccattaa aaggaaagat caaggagtaa accagaagaa gaagaaaaag aggacttcaa    240
 agctgggaag gatgagttct tgcagcaacg tctgtgggtc caggcaggca caggctgcag    300
 ctgagggtgg ttaccagcgc tatggagtcc ggtcctacct gcaccagttt tatgaggact    360
 gtacagcctc aattttggga gcatgaggat gattttcata tcctaagatc acctaccagg    420
 cggagcttta tatctttgaa ggggttgact cattctcagg tacacttttg tgatacctcg    480
 catggactgg cc                                                        492



      <210> 659
      <211> 2034
      <212> DNA
      <213> Homo sapiens


      <400> 659
 atggaatact atgcagccat aaaaaagaat gagatcatgc cttgcaggaa catggatgga     60
 gatggagact attatcctca gcaaactaat gcaggaatag aaaatcaaat acctcatgtt    120
 gtcacttatg tcttcaaacc tgtgcactct ggatttagct gctatgaccg gagtcttagc    180
 atgccgtaca ttgaaccaac ccaggaggca attccattcc tcatgttgct tagcttggct    240
 tttgctggac ctgcaattac gattatggta ggagaaggaa ttctctactg ttgcctctcc    300
 aaaagaagaa atggggtcgg actagagccc aacattaatg ctggaggctg caacttcaat    360
 tccttcctca gacgagctgt cagattcgtt gagaacaatg ttccagagcc tgcatcagcg    420
 acaggtctag aaagtccatt atccaaagga aaaagtgttc atgtatttgg attatgctct    480
 acagctctca ttacagatat catacagctg tccacaggat atcaagcacc ttactttctg    540
 actgtgtgca aaccaaacta tacctctctg aatgtatctt gcaaagaaaa ttcctacatt    600
 gtggaagata tttgctcagg atctgacctc acagttatca acagtggcag aaagtccttc    660
 ccttctcaac atgcaaccct tgctgccttt gcagctgtgt atgtttcggg cttgtatgct    720
 gtggggaatt tcctgcccag tgatgagagt atgtttcagc acagagacgc cctcaggtct    780
 ctgacagacc tcaatcaaga tcccaaccga cttttatctg ctaaaaatgg tagcagcagt    840
 gatggaattg ctcatacaga aggcatcctc aaccgaaacc acagagatgc tagctctctg    900
 acaaatctca aaagagcaaa tgctgatgtg gaaatcatta ctccacggag ccccatgggg    960
 aaggagaaca tggttacctt cagcaatacc ttgccgcgag ccaatacccc atctgtagaa   1020
 gaccctgtca gaagaaatgc gagcattcat gcctctatgg attccgctcg atcaaagcag   1080
 ctcctcaccc agtggaagaa taagaatgaa agtcgaaagt tgtccttgca agttatagag   1140
 cctgagcctg ggcagtcacc acccagatcc atagaaatga ggtcaagctc agagccatcg   1200
 agggtagggg tgaatggaga ccaccatggt cctggcaatc agtacctcaa aatccagcct   1260
 ggcgctgtcc ccggatgtaa caacagcatg cctggagggc caagagtgtc cattcagtcc   1320
 cgtcctgggt cctcacagtt ggtgcacatc cctgaggaga ctcaggaaaa cataagcacc   1380
 tcccccaaaa gcagctctgc tcgggccaag tggttaaaag ctgctgaaaa gactgtggcc   1440
 tgtaacagaa gcaacagcca gccccgaatc atgcaagtca tagccatgtc caagcagcag   1500
 ggtgtcctcc aaagcagccc caagaacact gaaggcagca cggtctcctg cactggctcc   1560
 atccgctata aaaccttgac agaccatgag cccagtggga tagtgagggt tgaggctcac   1620
 ccagagaaca acaggcccat catacagatc ccgtccactg aaggtgaagg cagtggctcc   1680
 tggaagtgga aagcccctga aaagggcagc cttcgccaaa cttacgagct caacgatctc   1740
 aacagggact cagaaagctg tgagtctctg aaagacagct ttggttctgg agatcgcaag   1800
 agaagcaaca ttgatagcaa tgagcatcac caccacggaa ttaccaccat ccgcgtcacc   1860
 ccagtagagg gcagcgaaat tggctcagag acgctgtcca tttcttcttc ccgcgactcc   1920
 accctgcgga gaaagggcaa tatcattcta atccctgaaa gaagcaacag ccccgaaaac   1980
 actagaaata tcttctacaa aggaacctcc cccacacggg cttataagga ttga         2034



      <210> 660
      <211> 1053
      <212> DNA
      <213> Homo sapiens


      <400> 660
 atgaggaagg acagtgaagg ttgtgagtcc aattgcaatc gtatcggcgt ggactgcatg     60
 tttaaaggct taagggaatc tgtctttgcc ttttgctccc gggttatgag aaaatgtatg    120
 tggctgtgcg tccaggacag caatgtgttt gtctctcagc caagctcagt cctcacccag    180
 gcaccggggt cacggtcacg ttcacgttcc gtggacgcct tgcacgcctc caagaggcgg    240
 gcatggggaa tcgtcgccgg cttacctggc cgtgggcgcg tcctggccgc tgcagcccgg    300
 agcagggtgc cagccgccgc cgccgccgcc atggtgtccc cggtcactgt ggtgaagagt    360
 gaaggaccca aactggtgcc gttcttcaag gccacctgcg tgtattttgt gctctggctg    420
 ccctcatcta gcccatcgtg ggtcagcacc ctcatcaagt gcctgcctat cttctgcctc    480
 tggctcttcc ttctggccca tggcctggga ttcctgctgg cccaccccag cgccacccgc    540
 atctttgtgg ggcttgtctt ctctgctgta ggtgacgcct tcctcatctg gcaggaccaa    600
 ggatacttcg tgcatggtct gctgatgttt gctgtgaccc acatgttcta cgcctcggcc    660
 tttggcatgc agccactggc tcttcggaca ggtctggtga tggcagcgct gtcgggcctg    720
 tgctatgccc tcctctaccc atgcctctca ggtgccttca cctacctggt gggggtctat    780
 gtggccctta tcggcttcat gggctggcga gctatggcag ggctgcggct ggccggggca    840
 gactggcgct ggacagagct ggcagctggc agtggtgcac tcttctttat catctcagac    900
 ctgaccatcg ccctcaacaa attctgtttt cctgtgccct actctcgggc gcttatcatg    960
 tccacctact atgcggccca gatgctcgtc gccttgtcag ctgtcgaaag ccgggagcct   1020
 gtggaacact acagactgac caaggccaac tga                                1053



      <210> 661
      <211> 437
      <212> DNA
      <213> Homo sapiens


      <400> 661
 cggaccgacc acaggtcccg aattgacgag tcgacgatat ccactgcaca gcggcttgag     60
 gacgtgctac tcccggttcg ggcacatcat tgccaggcac cctgtcttct tcgcctcggc    120
 gccggtgctc atctccatcc tgctcggcgc cagcttcagc cgctaccagg tcgaggagag    180
 cgtggagcac ctgctggcgc cccagcacag cctggccaag atcgagcgca acctcgttaa    240
 cagcctcttc ccggccaacc gctccaagca ccgtctctac tcggacctgc agacccccgg    300
 gcgctacggc cgggtcatcg tcacctcctt ccagaaagcc aacatgctgg accagcatca    360
 caccgacctg atcttaaagt tgcatgctgc tgtcaccaag atccaggttc caaggcctgg    420
 ttttaattac acgtttg                                                   437



      <210> 662
      <211> 1690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1690)
      <223> n = a,t,c or g


      <400> 662
 tttttttttt ttcagatttc acgtgtattt ttgctaaaac tgaaagctgt caggatccac     60
 attggtgtta ccagtttgta ctgaagcctg atacaatacc caacagtatt gctctggttt    120
 tttcaagcac acactccaag caagtggtca gtctggctta attcattatg gctttttttc    180
 agggtaagag attcacacgc aagagaataa ggctacaaat gctccaaaca tgggtccaga    240
 actctggctc ttttgtgagg cctagagtca cagaaaatgc catctgttaa gaagctgctt    300
 ttgcataaaa aaatataaaa agttacaaaa ttccatcaaa gacagataca cagtataaat    360
 cgttaggtga acacagaagg ctggtctcat ctcctgcagt ggcccataga cctgccctga    420
 ggtctggaag ttcactgtcc tgagggtcca ggaactcctg cctgctggct gggctctagg    480
 aagaaggagg gtttggctgg gcccgcccag ctccccatga cactgtcact gtgatgccac    540
 tgttgtaccc tctgtcttct ggaccagtca gtctatgagc tcttctttga aacagtctta    600
 gacccagaat ggtcatctca cccccagaag acatggtttc caagggtggg aggtgttagt    660
 tatgggtgcc gagccccact tcctgggcga caaggcaaag gtcaatttct ccctgcttca    720
 agaatgaaga gggaactggt gctccttgaa ccaaagattc ttggaagggt cattgtcacc    780
 aaagtggctg gtgtgggcag gagcaccaag tgcagacaaa cccaccgggg cctggcgggg    840
 cagccctgtc atggtttctg tctttgttcc tgttagtgaa acagaagacc cccgaccccc    900
 gccacctagc agcatggaac acctgctgcc cagatacaga caaggctctg ctttgtctcc    960
 ttgtgctggt ttttggcaga gacgttaaag ggctgaaggc ctgtgggaca gaaatgggga   1020
 gaaggagtgg gatacccaag atgccctcat acgcagcgtg gtcaacagtg ctgagctgag   1080
 gggcaagcct ggtaggctgg gctcaggcag aacctgaggc tgtagggggc ctgctgtgtc   1140
 cgcagccccc tctgcaactc agaagtccag gcctccgctc caacgccagc gacccctgtg   1200
 aggcgcaggg gtggaggcct gtgtggctca ggttgccaag gcacccgcca ggccttcagt   1260
 cagagtccga gtcggaattc tcttcttctg tcttgtgggc tgtggtctca tctgcagagt   1320
 ccccttgttt gaggaatttg gccacgtcgt taaagatcag gtagaaatca gttgcaaaca   1380
 cgatggtagc aaagaagcca aacaccccag cggctttgga agccccatcc gagtacttgg   1440
 cgatggccgt gatggagata gcaaagtaga tgagggccgc ggtgacacag cgcaggaagt   1500
 ccatcatggg ccagcacaag ccctgccact tgtcattcag ctgcatggca tcagcaaaga   1560
 ggaagtacaa ggccagcagg aactccagca gaggcgctgt gaggaaggca gatgctgagg   1620
 acgccacata gcagataaaa gtggaattcc nccgcnctcg cgagtggtca tcaggtctca   1680
 ttncnngcca                                                          1690



      <210> 663
      <211> 1423
      <212> DNA
      <213> Homo sapiens


      <400> 663
 atgaaagatt tttatttcaa attgcttttc cttttattat tgtagggctt aaaagacaac     60
 cttcttgctt ctgggacatc cagcctgaca gccaccaaac agttgcatcg tccaagaatc    120
 acgagaatct gcctcaggga cttgatattt tgtatggaac aggaacggga gatgaagtat    180
 tctcgagctc tatacctggc ccttctgaag tgaccactcc actcttccat ccagatcctt    240
 gctatttact gccaaagaag acacaaagca ttgttgcact gtcctgaaat ttcaatttct    300
 ggaaaataat caccaacatg aaagagcatt gtttacagtt agaaacttta ttaactctta    360
 cctatccatc tcatgggact cttacagact cagattcatc tttgtcttct gaaaatcagt    420
 tatgaaatac actttgcaca gaattaggca tctgcctatc tgtgcattaa attaaagcaa    480
 gttaaggccc tatttgttac tacctgcctc atttgccaaa ttgtagcagg tgaggtgtcc    540
 ttccctaata cagcatgcat tgagatgcag gagaaaggaa gaggcataag aaaatacaag    600
 aatgactatt tcattctata ttgaacctgt cccaaagtgg taggttttct gggctggaat    660
 cagaagttgc ttagctaact atgacagtca ccctctgtac gtgacaggcc actgtggtga    720
 ctttggtcgg ctgagttcca gtgttgtcaa aacaagacaa atggggatag attgtgcctg    780
 gggttgctaa ttctctgctt catatcacca tatgccgttt ctggtaccaa gtgaggggac    840
 atgcttgtca gggaaacctt aaaattgaat ctactgatat atcttgttga aaaaatggaa    900
 aaggtgcaaa gtattagaag gaacgttagg gcgttgcttt caaactgatg aggggaatgt    960
 gaaaatggta tcataaaaca ggaaatgtgc ttcatatgcc caagagggga agaggtggaa   1020
 tcggaactcc aaaacaactg gtacatgttt tgttgatggg caaaaaaaat cacagcacaa   1080
 ccagaaagga gaatgtacca gatgttttca aattagagta tttcaaaagg aaaatgttat   1140
 tttttgtttt gtattgtttt aaatcccaag gatagttttt atatttcctt ctgtcataat   1200
 atattttagt tatcctaatt tttaagcatg ttggcacatt taaaaaatcc taattgatga   1260
 tgagaaattt ttaacaatag gactttatgt tggattctgt acttaaaagg tactgtcaat   1320
 atctcactct tggggatatg agctctaaat atgagaagca agttatatgt gttcacctga   1380
 ggaagaagct gacggacaaa gcaaaccctc tttaaaaaaa aaa                     1423



      <210> 664
      <211> 2249
      <212> DNA
      <213> Homo sapiens


      <400> 664
 cccagcgccc cggaagtgat ctgtggcggc tgctgcagag ccgccaggag gagggtggat     60
 ctccccagag caaagcgtcg gagtcctcct cctccttctc ctcctcctcc tcctcctcct    120
 ccagccgccc aggctccccc gccacccgtc agactcctcc ttcgaccgct cccggcgcgg    180
 ggccttccag gcgacaagga ccgagtaccc tccggccgga gccacgcagc cgcggcttcc    240
 ggagccctcg gggcggcgga ctggctcgcg gtgcaggtaa agctccagat ggctctggaa    300
 cttatgagga aagagttgga ggacgccttg actcaggagg ccaacgtggg gaaaaagact    360
 gtcatttgga aggagaaagt ggaaatgcag aggcagcgct tcagattgga gtttgagaag    420
 catcgtggct ttctggccca ggaggagcaa cggcagctga ggcggctgga ggcggaggag    480
 cgagcgacgc tgcagagact gcgggagagc aagagccggc tggtccagca gagcaaggcc    540
 ctgaaggagc tggcggatga gctgcaggag aggtgccagc gcccggccct gggtctgctg    600
 gagggtgtga gaggagtcct gagcagaagt aaggctgtca caaggctgga agcagagaac    660
 atccccatgg aactgaagac agcatgctgc atccctggga ggagggagct cttaaggaag    720
 ttccaagtgg atgtaaagct ggatcccgcc acggcgcacc cgagtctgct cttgaccgcc    780
 gacctgcgca gtgtgcagga tggagaacca tggagggatg tccccaacaa ccctgagcga    840
 tttgacacat ggccctgcat cctgggtttg cagagcttct catcagggag gcattactgg    900
 gaggttctgg tgggagaagg agcagagtgg ggtttagggg tctgtcaaga cacactgcca    960
 agaaaggggg aaaccacgcc atctcctgag aatggggtct gggccctgtg gctgctgaaa   1020
 gggaatgagt acatggtcct tgcctcccca tcagtgcctc ttctccaact ggaaagtcct   1080
 cgctgcattg ggattttctt ggactatgaa gccggtgaaa tttcattcta caatgtcaca   1140
 gatggatctt atatctacac attcaaccaa ctcttctctg gtcttcttcg gccttacttt   1200
 ttcatctgtg atgcaactcc tcttatcttg ccacccacga caatagcagg gtcaggaaat   1260
 tggggcatcc aggggatcat ttagatcctg cttctgatgt aagagatgat catctctaaa   1320
 attctgttcc caagatgcag tcctagcgta gcgaacgttc ctggagtggg gtgaaggata   1380
 tcaatatact aagttttaac cagatacccc atttaggtca gcacttgatt cgttgttgct   1440
 gtgaaatatg tccatgggac aaaagaggga atatgaaata tttgcatatg ggaagattat   1500
 agagcataat aattttgtaa atggagcaat ctcaacctct atttctagat cacattttct   1560
 tgatgtcttc cttcaaatta atgaccttgg attacataag gatttctatg cattcattat   1620
 aatttgttat tcctttcaat atccttgtat ttcaaatctt ccatataaga attagacatg   1680
 gcaattctta aattgattca gaatggtctg atactattcc agtatcacct ccttaattct   1740
 gtttctcctc gttttcctga ttttccttct cattctctcc ttccccgctc tgtctctctc   1800
 tccctgtcac tctctctctc tcgttcctta ttttttgttt cttacctctt actgtttaac   1860
 ctgttgcttc cttctggatt aatacattta gagccattcc tttatatggt cacatttcct   1920
 atgactttac tcaattactt ttaaaatcct ttctattctg agactaattt ttaagaatta   1980
 caaagctcat tcttctgaat ctaatatcac taactcctag actttttccg ttttctttgg   2040
 atacacttta agtaggaatt tatcagaatt ttcattcaac tcgttcttta atgcagatat   2100
 ttactagtta taagacctta aggctgggtg cagtggctca cgcctgtaat cccagcactt   2160
 tgggaggctg aggcgggtgg atcacaagct caggagttca agaccagcct ggccaacatg   2220
 gtgaaaccct gtctctacta aaaaaaaaa                                     2249



      <210> 665
      <211> 2009
      <212> DNA
      <213> Homo sapiens


      <400> 665
 caaagtgctc agcataaggg agccagcgca cagcacagcc aggaaggcga gcgagcccag     60
 ccagcccagc cagcccagcc agcccggagg tcatttgatt gcccgcctca gaacgatgga    120
 tctgcatctc ttcgactact cagagccagg gaacttctcg gacatcagct ggccatgcaa    180
 cagcagcgac tgcatcgtgg tggacacggt gatgtgtccc aacatgccca acaaaagcgt    240
 cctgctctac acgctctcct tcatttacat tttcatcttc gtcatcggca tgattgccaa    300
 ctccgtggtg gtctgggtga atatccaggc caagaccaca ggctatgaca cgcactgcta    360
 catcttgaac ctggccattg ccgacctgtg ggttgtcctc accatcccag tctgggtggt    420
 cagtctcgtg cagcacaacc agtggcccat gggcgagctc acgtgcaaag tcacacacct    480
 catcttctcc atcaacctct tcggcagcat tttcttcctc acgtgcatga gcgtggaccg    540
 ctacctctcc atcacctact tcaccaacac ccccagcagc aggaagaaga tggtacgccg    600
 tgtcgtctgc atcctggtgt ggctgctggc cttctgcgtg tctctgcctg acacctacta    660
 cctgaagacc gtcacgtctg cgtccaacaa tgagacctac tgccggtcct tctaccccga    720
 gcacagcatc aaggagtggc tgatcggcat ggagctggtc tccgttgtct tgggctttgc    780
 cgttcccttc tccattatcg ctgtcttcta cttcctgctg gccagagcca tctcggcgtc    840
 cagtgaccag gagaagcaca gcagccggaa gatcatcttc tcctacgtgg tggtcttcct    900
 tgtctgctgg ctgccctacc acgtggcggt gctgctggac atcttctcca tcctgcacta    960
 catccctttc acctgccggc tggagcacgc cctcttcacg gccctgcatg tcacacagtg   1020
 cctgtcgctg gtgcactgct gcgtcaaccc tgtcctctac agcttcatca atcgcaacta   1080
 caggtacgag ctgatgaagg ccttcatctt caagtactcg gccaaaacag ggctcaccaa   1140
 gctcatcgat gcctccagag tctcagagac ggagtactct gccttggagc agagcaccaa   1200
 atgatctgcc ctggagaggc tctgggacgg gtttacttgt ttttgaacag ggtgatgggc   1260
 cctatggttt tctagagcaa agcaaagtag cttcgggtct tgatgcttga gtagagtgaa   1320
 gaggggagca cgtgccccct gcatccattc tctctttctc ttgatgacgc agctgtcatt   1380
 tggctgtgcg tgctgacagt tttgcaacag gcagagctgt gtcgcacagc agtgctgtgc   1440
 gtcagagcca gctgaggaca ggcttgcctg gacttctgta agataggatt ttctgtgttt   1500
 cctgaatttt ttatatggtg atttgtattt aaattttaag actttatttt ctcactattg   1560
 gtgtacctta taaatgtatt tgaaagttaa atatatttta aatattgttt gggaggcata   1620
 gtgctgacat atattcagag tgttgtagtt ttaaggttag cgtgacttca gttttgacta   1680
 aggatgacac taattgttag ctgttttgaa attatatata tataaatata tataaatata   1740
 taaatatatg ccagtcttgg ctgaaatgtt ttatttacca tagttttata tctgtgtggt   1800
 gttttgtacc ggcacgggat atggaacgaa aactgctttg taatgcagtt tgtgacatta   1860
 atagtattgt aaagttacat tttaaaataa acaaaaaact gttctggact gcaaatctgc   1920
 acacacaacg aacagttgca tttcagagag ttctctcaat ttgtaagtta ttttttttta   1980
 ataaagattt ttgtttccta aaaaaaaaa                                     2009



      <210> 666
      <211> 717
      <212> DNA
      <213> Homo sapiens


      <400> 666
 agcagtagcc tggacagcgg actccgaacc cctcagtgcc ggatctgctt ccagggcccg     60
 gagcaggggg agctcttaag cccctgccgc tgcgacggct cagtgcgctg cacgcatcag    120
 ccctgcctca tccgctggat cagcgagagg ggctcctgga gctgtgagct ctgctacttc    180
 aagtaccagg tcctggcgat cagcaccaag aacccactgc agtggcaggc catctccctg    240
 acggtcatcg agaaggtcca gattgctgcc atagttctgg gctcgctctt cctggttgcc    300
 agcatctcct ggctcatctg gtcctcactc agcccttcag ccaagtggca acgacaggat    360
 ctgctctttc agatctgcta cggcatgtat ggcttcatgg atgtcgtctg cataggcctc    420
 atcatccatg aaggctcctc tgtctaccgc atcttcaagc gctggcaggc agtgaaccag    480
 cagtggaagg tcctaaatta tgacaagacc aaggacatag gaggagatgc agggggaggg    540
 acggcaggga agccaggccc caggaactca cggacgggcc ccacctctgg ggccacgagc    600
 cgccccccag ctgcccagcg catgcggacg ctcttgcctc agcgctgcgg ttatacaatc    660
 ttgcacctcc ttgggcagct gcggccacca gatgcccgtt ccagctccca ttctggg       717



      <210> 667
      <211> 1589
      <212> DNA
      <213> Homo sapiens


      <400> 667
 agtagagaca gggtttcacc gtgctagcca ggatggtctc aatttcctga cctcatgatc     60
 cgccgtgccc ggcccttatt tcttaagaat agaaaactgt aggaatttgc atagtagatc    120
 acctggtgag acctcagttc tatggtgaga aaaattctct ataaaagcta tatggtccat    180
 gatgtcatcc aaccccacat aagcatataa aatacatgat aaggctctcc aggaaaaaat    240
 attcacaaga aataatgact tctttcatca gcttaaaagt gggaagaact tatttgatta    300
 aaaccctgtt taaaatcgat tgtcttgtta gacttcccct atccataatg aaatcattac    360
 agggttctaa tgtcaggtgg aaaagtgttg actatggagt tgtttagcct ctgatcctag    420
 gataaaccaa gcagttaaat aatttccaaa agtacaaaca gacattcccc tcaagttatc    480
 cgggcttcta caggtacttt tcaagtgacc cacaagccct atattttaaa cagccacaga    540
 agtcagaacc aaattcaggt ttccaacaaa cactgtaaaa tgctattcag caaaagctgc    600
 agttccccgt ggcagcttgt caggtggtca gtcagtctca attactctgg gttcctctgc    660
 aattgctgtc atgaccgtga gcctctcacg ttctacttgg ctgacagccc aggtctgagg    720
 aagtgagagc caacaatcgc ttactcagca gcgcattgtg tcgcttcagg tattcaaagg    780
 agtctccttg cttttcaaca atttcttcta ggcttgaaat agttctgaat ccagtctccg    840
 aggtaatatt gctggggtaa gcatagattt tttcttcttc aagtatatca ggctctggtt    900
 tagctttatt aaatctccgg attttcactg tgtaaatgag gagacatatc agggaacaga    960
 tgagttccag tgccaagatg gccagaatga ggtcaagata caatctgcca ggctctggga   1020
 aggagtgctg catgcacagt atgaggagaa gcactgtgtt gccagaggac tgtatcatca   1080
 acgcaagtct ccttgagatc cccttgttgg atcggtagat caagttaata ccctcggttt   1140
 cctgattttg cctgtggtga atactggatg ttaccattca aggaattaaa tggagaatcc   1200
 cacaaaataa ctttccccaa ggattataac cgtctgaact ttcaaatggg tttgtgtaat   1260
 ttccctgggc acttgtcctc atttggatta ggataagaac aaagcacacc tgttaaaaat   1320
 gctaaaacaa caaacacgag atgaataaac cacagaagat tcactatgat gactgtagga   1380
 agaggatgga atcggggtct aaagtgagct tgtaatgagt ggtgtgggag aagctgggca   1440
 tccagaagtg ggtcgtcttc aatactctgg gtgatatcca aggaaccgtc ctccatcctg   1500
 ccccccgccg ccatttcccg acgccggaga gccgaagccc tggccagccc ggcctctcca   1560
 cctggacctg taagcctctg gccgcgaaa                                     1589



      <210> 668
      <211> 5511
      <212> DNA
      <213> Homo sapiens


      <400> 668
 caccatattt caatatcacg atttaggagg gaggcaagta taaagtgtag aaatctgaat     60
 tatggaagag atttcttttt ttttcataaa gaaatgccac tttattattt tcaagtagat    120
 aggtagtacc tcaaactaat gtcttacaaa aggtcaccaa taaagatcct gtagatgttt    180
 ctttaacaaa tacataaaga ttgatgataa ttagcccatg cactcgctgc ttctaaaagg    240
 atatttctaa agtgcctgaa aagtattgtt tttggtagac taaacatgcc acctctagca    300
 atattgttta tgctcttaat ttactaaaaa aatgccattt ttattgattg tgcaaagata    360
 aacttttgtc cacagttagt aatctccaat taatcggatc caaattaata ttgtctccca    420
 cttagattcc caggcccaag gcaatgactc ccttacttcc ttgcttctga taaagcaaaa    480
 ttccagtgca atgaaatgac agcctttggg aggtggttta tgggtctgac ccaatgcttg    540
 tcttttgtgc ttccttcctg tctgccttag gtcttccatt ttcctcagat gtctttctca    600
 cttgcatgac ctatctaggt ctctctctac aggacattcc cagtgccttc taagccaggc    660
 ttagagaatg ggcaaggctg cctgcagagc aaaagtgtta gatagggagt aagggaaaga    720
 aagctatctc ctgtaggaac ctgaaaccaa ctctccagcc cagggtaagt gggcacaatg    780
 atcgtcggtt tgaagggcat ttgcctggag ggaacagccc tgccacctaa gacgtcaaaa    840
 gcaaatcatt tttttttttt ttgagatgga gtctcaccct ttcgcccagg ctggagtgta    900
 atggcacgat ctcagctcac tgcaacctct tcctcacagg ttcaagcaat tctcctgcct    960
 cagcctcctg agtagctgag attacaggcg tgtgccacca tgactggcta attttttgta   1020
 cttttagtag agacagggtt tcaccatgtt ggccaggctc gcctcgaact cctgacctca   1080
 tgatccacct gcctcggcct cccaaagtgc tgggattaca ggcatgagcc accgcaccca   1140
 gaaaaagcaa atctcttagt atttttcctc ttgtccaaag gttctgacca tgttcatgac   1200
 ctaagcttgt ccctggaagc atacatgtcc ctgggagaca ggaaggttca gggaacttct   1260
 ccaccctgat tctagccaat ggccagcgaa ctccttttcc agggttggct tggcagtgtc   1320
 ggggaatgat gcaggttcat cgggatgggc atgaaaagaa agggaatgga agaggctggg   1380
 aaagaacttg tggccatccc tttcagaaca gcatggagct ctgaggactt agtattacag   1440
 aaggtgaagt gttattaagt acatgagtga catccggacc ttgtggacta agaggacccc   1500
 taaccaaggg tcagcgggga actctgtggc acacaagtgt ggcatttctg gaagctcttg   1560
 attgccttct ggtcctgcct ctgctgctac cctgatgaga tctgagtttg ttctgctggt   1620
 ggggtattct aaaatgtggg acgtagagct ggagtccacg acatctatct ggagactcat   1680
 gtcaaatgtc ctgtcattgg cactacctca cttcctttgt tgtttccttc ctccagccag   1740
 ccctacctcc atctcccacc tgtctgccca gctctccctg aaggtccctt accagcctcg   1800
 actgggagac aagtccacct tttccagtct caggctcttg cactcaccag aagaaccttt   1860
 tgtgattgca aggtctgaag gggaagccag ggatagagtc ctgcaggaag ctaacggggg   1920
 tggaagtggg aaatggagtg aggctggggt gatctgagag ggcttccttc tggtttagat   1980
 gggttcctgc ttttggatgc tgatctatta cagtaggaag tggggttgaa gggatgggag   2040
 tgggcagggt ggggtaaccc ttaattcctc agaaaaaata gacaacatag tggagtggga   2100
 tggaaaagga tctggtcggg gggactctaa cacatagtgt ctaatctgat tgttcacagt   2160
 taggtctatg gggtcatcac cccaatttat ataccccgca acttagcctg ctgagttgcc   2220
 tcattatctc tccccaaatg ttgccaccca atgccacccg ttatttccat ccctctccat   2280
 caccatcccc acaacacctc cagagctccc catctttcca tgcctggttc ttcttccaat   2340
 ggggtcagta gtatgtctcc ttctccaccc agccaccagg ataccgccgc aggatgagct   2400
 ttcggacctc atcatagatg aagatgagga ggctgtaggg gaaggcgcag aaccaccagg   2460
 tgactttgag cgggtacatg cggagggcta cacccatgcc tgggcagtaa gagagaaagg   2520
 cagccaacgc cgtctcctcc aggagcccaa aaatcaggat cttgttcttc atgccctgct   2580
 ggaagactga gttgcggcgg gtcttgcaga tgatgaggtc agcccactgc accaccacga   2640
 tgctggcaaa gaatgccgtg tggcacgtga actccaccac cttccgctgc tcataggtcc   2700
 actcctgtcc atagctgtcc tccagatcat tcatggtccg gtcatcccag tcgaggcgga   2760
 ttcccagtag ccgtgatggc aggaaaccgt tctctgccag gatcacaaag taggtgaaga   2820
 agccacccag tgcctggatc atcccgatct gtccgtaggc catgctgatg agcctctcat   2880
 tcaccagctt gtccgtctgg gagtttcgtg gctgccgctt catgatatca ctctcagctg   2940
 cctcataggc caaggagatg gcagggacca tatctgtgcc caggtcaatg caaaggatgg   3000
 tcacagtgcc cagaggtagg gggatgttgg caatgatgaa cagcaggaag ggggtgatct   3060
 cggggatgtt gctggtcagg gtgtaggcga tggatttctt caagttgtca aagatcaggc   3120
 ggccctcctc cacccccgtg acgatggagg caaagttgtc atccagcagg atcatgtcgg   3180
 ctgcctgctt agagacgtca gagccagaga tgcccatggc aatgccaatg tcagccttct   3240
 tcaatgcagg ggagtcgttc accccgtcac ccgtcacggc cacaatggct ccctgcctct   3300
 gacatccctc cacaatgatg agcttctgct ggggagacgt tcgagcaaag acgatctctg   3360
 tgtggttctt gaggatctca tcgagctgct ccgatgtcat gtccttcagg tcagagccgt   3420
 gcaccacgca tgccttggct tctctggggt tgacttgact catgggaatg ttgagccggg   3480
 ctgcaatgtc ctccacagtc tcgttaccct ctgatatgat gcccacgcct ttggcaatgg   3540
 ccttggctgt gatagggtga tccccggtta ccatgatcac cttgatgcct gcgcttcggc   3600
 acttgcccac agcatctggc acagcagccc ggggagggtc aatcatagac atgagcccca   3660
 caaagcaaag cttctccgtg ggaaagttca gctcatccgt gtcgaatttg aagccccgag   3720
 gaaactttcc agatggcaga ttcagttgac agaatcccag cacacgctcc ccaagtcccc   3780
 ccagctccat gtaggcattt tgaaaggcat cttgcatctc cttgtcgagc gggatctcct   3840
 tgccctgcac caggatggtg gagcaccggt ccagaatgcg ctctggggcc cccttcatca   3900
 ccagcacgtg gctctggggg ctgtcttctc gctcgtggat agacagctgg tacttgttgg   3960
 tagagttgaa aggaatctct gccaccttgg ggtttctgtc tctcattttc ctcactgagc   4020
 cacaggagag ctcaatgcac ttgagcagag ctgactcaga ggcatcacca gctgtgtccc   4080
 gcttagacac ggagatgttc tcctgtcctg ccttgaagac ggcgcggttg cagagaccag   4140
 caattcgaga cagggccgtc cacgtagggg atcgtttgtc aaaagtggcc ccagactgat   4200
 cttcggtggt gtcagcctca tggatttggt tgtcgaacca catgtgggcg acggtcatgc   4260
 ggttctgggt gagggtgccc gtcttgtccg agcagatggt ggacgtggag cccagcgtct   4320
 ccaccgcctc caggttcttc accaggcagt tcttccgtgc catgcgcttg gctgtcaggg   4380
 tcaggcacac agtgacagtg gccagaagcc cctcaggcac gttggccact atgatgccga   4440
 tgaggaagat gactgcctcc agccagctgt agcccaggat gagggagagc acgaagaagg   4500
 agacccccag gaatacagcg acccctgtga tcagctggat gaagtgttca atctccattg   4560
 ctatgggtgt ccgcccaacc tccaggcctg aggcgagagt agctatgcgg cccatcaccg   4620
 tccggtctcc tgtggcaatc acaatgcccc tggcagtgcc ttcaacacag ttggtggaga   4680
 agaaacagat attgcgggtc tccagggggt tctcatgggt gaactcgggg gagcgggtct   4740
 ggggctccga ctctcctgtt aaggatgagt tatccacctt acagccatga gaagagatga   4800
 tccggaggtc agcagggacg cggtctccac ccttcacctc caccaggtct cccaccacca   4860
 cttcctctgc gttgatctgc atcttctctc cctcccggat cacaagggct tgctgaggta   4920
 ccatgttctt gaaggaatcc atgatcttgg agctcttggc ctcctggtag taggagaagc   4980
 agccagtgac aatgaccaca gctgccagca ccacacccag atatagattg tcgttggatg   5040
 gttcatcctc catggcagcc tggatgccgt aggccaggaa gcagaggata gccccaatcc   5100
 acagcaggat ggagaacccc ccgaaaagct gacggcagaa cttgacccac tcaggggttg   5160
 tgggaggtgg tgtgagggcg ttgggcccat ctcgagccag aacgtcctga gcccgctggt   5220
 tggtgaggcc cttggacagg tccacttggt atttgcggcc cagctcatcc aaggacagct   5280
 tgtggtcatc cattgccacc tccttcttca gctcatccag ttccttctcc ttctgtttct   5340
 tcttgccgcc cccattctct gccgtggtgg cggcaggtga gtactcacgg ccagccccac   5400
 ggcccatctt ggggcagagt ggctgaggga ccttagcggg agaggtcacc aggaggatcc   5460
 caagcccaca ccagcccgtc tgggacagtc ggagaccctg gcagacagag a            5511



      <210> 669
      <211> 1077
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1077)
      <223> n = a,t,c or g


      <400> 669
 tttttttttt ttctgaacaa taaatgtttt atttgcttta aaagtgcctc tgaaagggcc     60
 ccccagaagt gagcagtgcg ccgtcaagcg ggtgtgcagg gcacacagct gcacggcaca    120
 gtgtgggtct gagtcactgc cggaggaggg accagggtgg tctgggccgc agccccttta    180
 acaatctgcc cttcctgccc tgcaggaaga acccattctg aacacaccct ggctgtccct    240
 ggctgcccca ctttggggtg acaaagagga ggcagccctg ggctgagtcc acagagacca    300
 gccctgatat ggcaggagtg ggggtggggt gggggagtgg gaatacagga gctcagcccc    360
 agctcaccac ggcatccccg aagagttgtg actcagacac acctgggttt aagtcccagc    420
 tgggggctca ggtaagtcaa atcgtcttct ggggcctctg tttatcagta gaaggctcca    480
 gaagtataca ctgttgatgg ctccttcccg ctctgatgca ccatgcctga ttaagcatac    540
 actgagcccc ctgggtcaga aatcgctgag gatgctgatg tcagcaaagt cagcccggta    600
 gcggtgggca tagaggctga gcaggaaggc ccacttgaag gaaatgaagc tccagacgct    660
 ggagaggtag tagctggtgg ggtctgtgag gctctgatgc cgggtgatgg ccagcacgag    720
 gaaggtgcag aaggcagcga tggagacggc cgagaagagg acgcccacga agaagaagcc    780
 gcgcagcccc ttgagccagg tcctccaata atcttgcatg tacatcacgt gcgtcaccag    840
 gacccacagt gccagcaccc ctgcgagccc tcccatggcc gcggtccccg gctgtcggta    900
 gaccaccgtc cagacgagga agatggagaa gccggccacg gagctgatgc cggagtaggc    960
 ggcgcggagg ccgagctgca gcctggacgg ggccatgggg ctgccgtacg cgtgggcgga   1020
 cgcgtgggtc gtcccgggcn ttccgcgacg gtactcaggg cgtcaggnnn ngcaccc      1077



      <210> 670
      <211> 1491
      <212> DNA
      <213> Homo sapiens


      <400> 670
 atgggcctct ttgaaggtac atttagagaa gaacagaaat gtacatacca atttctgatg     60
 caaggattca tctgcaaaca gactgaccaa gtggtcctaa ttcttgatag cgctgatgcc    120
 atttgggcaa ttcagaagtt atatccagtt gtatctgtga ctagtggttt tgttgatgtc    180
 tttagcagtg taaatgccaa tattccctgc tctacttctg ggtcagtgtc tactttctat    240
 tctatcttac ccatcaggca aatcaccaaa gtctgcttca tggatcaaac tcctcaagtt    300
 ttgcgctttt ttctattggg gaacaaaagt acctccaagc ttctcttggc tgtattctac    360
 catgagctcc agagccccca cgtcttctta ggggaaagtt ttattccacc cactctggtt    420
 cagtcagctt ccttattgct gaatgaatct attggtgcca actatttcaa catcatggat    480
 aacctcttgt atgttgtcct acaaggagag gagcccattg aaatacgctc aggtgtttcc    540
 attcacttgg ccctcactgt gatggtttca gtcttagaaa aaggctggga aatagtaata    600
 ctcgaaagac taactaactt cttacagatt ggccaaaacc aaatcaggtt tattcacgag    660
 atgcctggcc atgaagagac cttaaaggcc attgctgaca gtagagcaaa aagaaagcgc    720
 aattgcccta ctgtgacttg cactagtcat tatagaagag ttggtcaacg taggcctctc    780
 atgatggaaa tgaactcaca tagggcttca cccccaatga ctgtggaaac tatctcaaaa    840
 gtgattgtca ttgaaattgg tgattcgcca acagtaagga gcactggaat gatttcatcc    900
 ttatcaagta acaaattaca gaatttggct catcgagtca tcactgctca acagactggg    960
 gtactagaga atgttctgaa tatgactatc ggggccttac tagttactca gtcaaaggga   1020
 gtcattggct atggaaatac aagcagtttt aaaactggga acttgatata tattcggccc   1080
 tatgcacttt ccatcctagt ccagccttca gatggagaag tgggaaatga gcttccagtg   1140
 cagccacaat tggtattttt ggatgagcag aatcgaagag tagagtccct gggacctcct   1200
 tcagagccat ggacaatttc agcttccctg gaaggagcat cagactcagt gctaaaaggg   1260
 tgcacccagg cagaaactca agatggttat gttagcttct acaacttggc agtcttgatc   1320
 tctgggtcaa actggcactt tatttttact gtcacttctc ctccaggagt caattttaca   1380
 gctcgatcca agccatttgc tgtcttgcct gtgactagga aggagaagtc gaccatcatc   1440
 ctggctgctt ccctgtcctc tgtggcctca tggctggctc tgagctgtct g            1491



      <210> 671
      <211> 2017
      <212> DNA
      <213> Homo sapiens


      <400> 671
 tttcgtgcgg gagatcagag gtcccgccgt cccgcgcctg acctcggctg aggacaggca     60
 ccgccatggg ccacacgcac acagcccgga gttgcagcgg accggcagag attacagcct    120
 ggactacctg cccttccgcc tatgggtggg catctgggtg gctacctttt gcctggtgct    180
 ggtggccaca gaggccagtg tgctggtgcg ctacttcacc cgcttcactg aggaaggttt    240
 ctgtgccctc atcagcctca tcttcatcta cgatgctgtg ggcaaaatgc tgaacttgac    300
 ccatacctat cctatccaga agcctgggtc ctctgcctac gggtgcctct gccaataccc    360
 aggcccagga ggaaatgagt ctcaatggat aaggacaagg ccaaaagaca gagacgacat    420
 cgtaagcatg gacttaggcc tgatcaatgc atccttgctg ccgccacctg agtgcacccg    480
 gcagggaggc caccctcgtg gccctggctg tcatacagtc ccagacattg ccttcttctc    540
 ccttctcctc ttccttactt ctttcttctt tgctatggcc ctcaagtgtg taaagaccag    600
 ccgcttcttc ccctctgtgg tgcgcaaagg gctcagcgac ttctcctcag tcctggccat    660
 cctgctcggc tgtggccttg atgctttcct gggcctagcc acaccaaagc tcatggtacc    720
 cagagagttc aagcccacac tccctgggcg tggctggctg gtgtcacctt ttggagccaa    780
 cccctggtgg tggagtgtgg cagctgccct gcctgccctg ctgctgtcta tcctcatctt    840
 catggaccaa cagatcacag cagtcatcct caaccgcatg gaatacagac tgcagaaggg    900
 agctggcttc cacctggacc tcttctgtgt ggctgtgctg atgctactca catcagcgct    960
 tggactgcct tggtatgtct cagccactgt catctccctg gctcacatgg acagtcttcg   1020
 gagagagagc agagcctgtg cccccgggga gcgccccaac ttcctgggta tcagggaaca   1080
 gaggctgaca ggcctggtgg tgttcatcct tacaggagcc tccatcttcc tggcacctgt   1140
 gctcaagttc attccaatgc ctgtgctcta tggcatcttc ctgtatatgg gggtggcagc   1200
 gctcagcagc attcagttca ctaatagggt gaagctgttg cttgatgcca gcaaaacacc   1260
 agccagacct gctactcttg cggcatgtgc ctctgaccag ggtccacctc ttcacagcca   1320
 tcagctttgc cctgtctggg gctgctttgg gataatcaag tctacccctg cagccatcat   1380
 cttccccctc atgttgctgg gccttgtggg ggtccgaaag gccctggaga gggttttttc   1440
 accacaggaa ctcctctggc tggatgagct gatgccagag gaggagagaa gcatccctga   1500
 gaaggggctg gagccagaac actcattcag tggaagtgac agtgaagatt cagagctgat   1560
 gtatcagcca aaggctccag aaatcaacat ttctgtgaat tagctggagt aggagtctgg   1620
 gagtggagac cccaggaaac agcatgaggt gcttactcag gaagtcagga catttttggc   1680
 ctttggctta acttccagat gctcagtcgg cttggggaag gactgaaggg cagctgccaa   1740
 gacctcagtt acctcctgac ctgagggtgg agagtggcag gaagcaagca tgtttgctgt   1800
 gcacttagga aaggctggtg agccagaggg actgatcagg ccccattcac tctctactca   1860
 ttaaaaggtc ctgagccacg aagcgcttcc cattttgaac tttctgtcct cacagattct   1920
 gtttgacaga atctaagggc catcagggaa ctcttttcat cttgcaaaga gaaaaagcca   1980
 gtctttccag aataaatatt catctgtttg aaataaa                            2017



      <210> 672
      <211> 454
      <212> DNA
      <213> Homo sapiens


      <400> 672
 ggcggcgccc atggagctga tctgctggtc agggggctgg gggctgccgt cagtggacct     60
 ggacagcctg gccgtgctga cctatgccag atttactgga gctccactga aggtacacaa    120
 gatcatcaac ccctggtaga gcccttcagg aactctgcct gcccttcgga ccagtcatgg    180
 agaggtcatc tcagttccac acaagatcat tacccacctt ctaaaagaga agtacaatgc    240
 tgattatgat ctgtcagctc ggcaaggggc agacaccctg gccttcatgt ctctcctgga    300
 ggagaagttg ctcccggggc tggtacatac tttttggata gacaccaaga actacttgga    360
 agtgacccgg aagtggtatg cagaggctat gcccttttcc cttaacttct tcctgcctgg    420
 ccgcatgcaa cggcagtaca tgtaacggct accg                                454



      <210> 673
      <211> 454
      <212> DNA
      <213> Homo sapiens


      <400> 673
 ggcggcgccc atggagctga tctgctggtc agggggctgg gggctgccgt cagtggacct     60
 ggacagcctg gccgtgctga cctatgccag atttactgga gctccactga aggtacacaa    120
 gatcatcaac ccctggtaga gcccttcagg aactctgcct gcccttcgga ccagtcatgg    180
 agaggtcatc tcagttccac acaagatcat tacccacctt ctaaaagaga agtacaatgc    240
 tgattatgat ctgtcagctc ggcaaggggc agacaccctg gccttcatgt ctctcctgga    300
 ggagaagttg ctcccggggc tggtacatac tttttggata gacaccaaga actacttgga    360
 agtgacccgg aagtggtatg cagaggctat gcccttttcc cttaacttct tcctgcctgg    420
 ccgcatgcaa cggcagtaca tgtaacggct accg                                454



      <210> 674
      <211> 415
      <212> DNA
      <213> Homo sapiens


      <400> 674
 gacatatgat ttgtgctggt acagaaaaag ttgatgatga tgctttgttg gtgttttggg     60
 atgcaaggat gaattctgag agtttatcta caactaaaga ctcacttggt gcatattcag    120
 agacacatag tgatgatgtc actcaagtac gtttccatcc cagcaatccc aacatggtag    180
 tctcaggttc atctgatggc ctggtaaatg tatttgatat taatattgat aatgaggagg    240
 atgcactggt tacaacctgt aactcaattt catcagtaag ctgtattggt tggtctggga    300
 aaggttataa acagatttac tgcatgacac atgatgaagg attttattgg tgggatctta    360
 atcatctgga cactgatgaa ccagttacac gtttgaacat ccaggatgtc agagg         415



      <210> 675
      <211> 3341
      <212> DNA
      <213> Homo sapiens


      <400> 675
 gaaccaagag agcctggtgc agtgccaggg gcctgccatc atcggggccc tcctgcgaaa     60
 ggtcccaagc tgggccatgg acatgaacgt gctcatgtcc gcccagctgc tgatggagca    120
 ggtggcagct gagggcagcg ggcccctcct gtacctactc taccagcatt tgctcttcaa    180
 ctttcacctc tggaccctca gtgacttcgc cgtgcgcctc ggtcacatcc agtacatgtc    240
 cagcatagtt cgggagcaca gacagaagct gcggaagaag tacggcgtcc agtttatctt    300
 ggatgctctg cgcacccact acagcccgca gcgggagcgc cccctggctg ctgacgacct    360
 acgcaccgtg cagacctccc tcctgggcct ggcgagggag ttcctggtgc ggagtctctc    420
 agcagatgac gtgcaggtca cgcagaccat gctgagcttt ttggcggcca caggcgatga    480
 cggtcaggcg gtgggtgcgc tggacctgct gctggccctg ctgcacggtt ccctggtgca    540
 ggagtccttg gctgtctttc tgttggagcc agggaacctc gaagtgctac tggccctgct    600
 agtgcggcca gggtcactgc ccctgctgcc cgatcgagtc tgcaagatcc tgcgcagact    660
 gcagcagaat gagcggctac ctgagcggag ccgccagcgc ctccggctgc gggagtgtgg    720
 tctccagggt ctggttgcct gcttgcctga ggggactgtt tccccccagc tctgccaggg    780
 cctctacaag ctgttcctgg gggcagattg cctgaacctc tcagatctgc tggctgtggt    840
 acagctgtcc ctccaggctg acctcagcgt tcgcctagac atctgtcgcc agcttttcca    900
 cctcatctac ggacagccag atgtagtgcg gcttctggcc cgacaggctg gctggcaaga    960
 tgtgctgacc cggctatatg tcctggaggc tgccacagcc ggcagccccc ctccgtcttc   1020
 cccagagtca cctacctccc ccaagccagc cccacccaag ccacccactg agtcacctgc   1080
 tgagccttca gatgtcttcc tgccctcaga ggccccctgc cctgaccctg atggctttta   1140
 ccatgctctc tccccattct gcacgccctt tgacctgggc ctggaacggt ctagtgtagg   1200
 atcaggcaac actgctggtg gtggcggcag cagtgggact cttactccag ccagccagcc   1260
 cggcactcct tcgccactgg atgggccgcg gccctttcct gctgctcctg gccgccacag   1320
 ctccagtctc tccaatgtgc tggaggacgg cagcctcccg gagcccacca ttagcgggga   1380
 tgatacctcg aacaccagca acccacagca aacctctgag gaagagttgt gcaatctgct   1440
 caccaacgtg ctgttctcgg tgacgtggcg tggcgtggaa ggcagcgatg aggctgcctg   1500
 gcgggagccg tggccaggtt ttctcagtgc tcacccagct gggggcctca gccacacttg   1560
 tgcgcccacc agactgcatc aagcgcagcc tcctggagat gatgctggag tcagccctga   1620
 ccgacatcaa agaggccccc gtgggggtcc tggccagcct cacccagcaa gcgctttggc   1680
 tgctgcgtct gctgcaggac ttcctgtgtg ctgaaggcca tggtaaccag gaactgtgga   1740
 gtgagaagct ctttgaaggt gtatgcagcc tacttgatcg cctgggagcc tggccccacc   1800
 tggccaacgg cacagctgat ctccgtgaga tggcgcagat tggcctacgg cttgtacttg   1860
 gctacatcct gctggaagac ccacagctgc atgcccaggc ctacgtgaga ttgcacatgc   1920
 tgctacagac tgcagtgcca gcccgccgcg aggaggcctg ctatgtgctc tccaagctgg   1980
 aggctgcact ggggcgggtg ctgaacacct cttctttgga gtcagccact gatgaggcag   2040
 ggtccccact tgcagctgca gcagctgcag cagctgcaga gcgctgctcc tggctggtgc   2100
 cactggtgcg cacgctgcta gaccgtgcct atgagccgct ggggctgcag tggggactgc   2160
 cctccctgcc acccaccaat ggcagcccca ccttctttga agacttccag gctttttgtg   2220
 ccacacccga atggcgccac ttcatcgaca aacaggtaca gccaaccatg tcccagttcg   2280
 aaatggacac gtatgctaag agccacgacc ttatgtcagg tttctggaat gcctgctatg   2340
 acatgcttat gagcagtggg cagcggcgcc agtgggagcg cgcccagagt cgtcgggcct   2400
 tccaggagct ggtgctggaa cctgcgcaga ggcgggcgcg cctggagggg ctacgctaca   2460
 cggcagtgct gaagcagcag gcaacgcagc actccatggc cctgctgcac tggggggcgc   2520
 tgtggcgcca gctcgccagc ccatgtgggg cctgggcgct gagggacact cccatccccc   2580
 gctggaaact gtccagcgcc gagacatatt cacgcatgcg tctgaagctg gtgcccaacc   2640
 atcacttcga ccctcacctg gaagccagcg ctctccgaga caatctgggt gaggttcccc   2700
 tgacacccac cgaggaggcc tcactgcctc tggcagtgac caaagaggcc aaagtgagca   2760
 ccccacccga gttgctgcag gaggaccagc tcggcgagga cgagctggct gagctggaga   2820
 ccccgatgga ggcagcagaa ctggatgagc agcgtgagaa gctggtgctg tcggccgagt   2880
 gccagctggt gacggtagtg gccgtggtcc cagggctgct ggaggtcacc acacagaatg   2940
 tatacttcta cgatggcagc actgagcgcg tggaaaccga ggagggcatc ggctatgatt   3000
 tccggcgccc actggcccag ctgcgtgagg tccacctgcg gcgtttcaac ctgcgccgtt   3060
 cagcacttga gctcttcttt atcgatcagg ccaactactt cctcaacttc ccatgcaagg   3120
 tgggcacgac cccagtctca tctcctagcc agactcccag accccagcct ggccccatcc   3180
 caccccatac ccaggtacgg aaccaggtgt actcgtggct cctgcgccta cggcccccct   3240
 ctcaaggcta cctaagcagc cgctcccccc aggagatgct gcgtgcctca ggccttaccc   3300
 aggtgagagc cctgggtgtg agggatgtga agtcgggacc c                       3341



      <210> 676
      <211> 724
      <212> DNA
      <213> Homo sapiens


      <400> 676
 atgacacatt tgaagcctcg aaccgcggcg gaccccgcgt gcgctcgaag ataaccaagc     60
 agtcttttaa agaaaagatt tgttgccttg ccaactaata cgacctcatc gagacctctg    120
 actgagtgtt gtagtgatgc aggtgactct cctttgaaac ctgtcagctg tccaaaatct    180
 aaagcatcag acaagcggag tttacttcca catcacatca ggcagatata tgacgaatta    240
 tttcagatac atgtgaaatt gcagtgtgaa actgcagcac aacagaaatt tgctgaagaa    300
 cttcaaaagc gagaacgttt tttacttgaa agagaacaac tgcttttcag acatgaaaat    360
 gccttgagta aaattaaagg tgttgaagaa gaggttctta caagatttca aattataaaa    420
 gagcagcatg atgcagaagt tgaacactta accgaagttc ttaaggaaaa gaataaagaa    480
 accaagagac tgaggtcctc ttttgatgca ttgaaagaat tgaatgatac cttaaaaaaa    540
 cagttaaatg aagcaagtga agaaaacagg aagatagaca ttcaggctaa aagagttcaa    600
 gctcgtttag ataatttaca gaggaagtac gagtttatga caatacagag attgaaagga    660
 agttcccatg ctgttcatga aatgaaaagt ttaaaacaag aaaaagcacc agtttcaaaa    720
 actt                                                                 724



      <210> 677
      <211> 1189
      <212> DNA
      <213> Homo sapiens


      <400> 677
 cgctatgaga gtagcggcga gcggctggct tgtcccgccc ctgcccctga gagacagaac     60
 cgtggacagc aacatttccc acaggacacg aagtttgtcg gcccttgcct tggcagagct    120
 gagtaagaaa aatcaccaag aatattattt ttggtatttg gaattgaatt tgccaggaat    180
 gcaagcactg ctacctaact aaagaccttg gctttggaaa catcttaccc cttgggcagc    240
 tcctcccaga gtttagactt ggcagcatca aagacacaac cgcaagccag gcattttgga    300
 gatcaaagat gggtagaaaa gatgctgcta ctataaaact tcctgttgat cagtacagaa    360
 aacaaattgg taaacaggat tataaaaaaa ctaaacctat tttacgagca accaaattaa    420
 aagcagaagc aaagaaaaca gcaataggca taaaggaagt tggccttgta cttgcagcta    480
 tattggcact actactggct ttctatgctt tcttttatct cagactcacc acggatgttg    540
 accctgatct ggaccaagat gaagattagc taagcaacaa tcaatgcatg aaagagaaat    600
 aactttacgg aaagcacctt ttgggaccaa aactttcaat actgaaactg taacatcttt    660
 aattctttct gctaatattt tcagtttgca gacatatgat ttttgatagt tgcataggat    720
 gtcaggaaaa gaaccttacc tagcaatgca gtatagtatg tgctactgga tacttttata    780
 tatctttctg ctttgacagc caccctatac atggtacatt tagatgaaat gggaaccagg    840
 atcctaaatt tttcaaatgt cattgccgaa tttatgtgta taattcccat cacttcctga    900
 tgagtaagtc ctatttttgg ttcctatata catccataag ttagtatata ttccttattt    960
 acagaaacat gcctcaaatc acattcagaa agaacaaaaa gtcatgggaa attttttatt   1020
 ttacaacaaa gccctgcttt ctttctggac gtattttaca tcattagaga gactatctgc   1080
 acatacatct accataatct ttttccttct ttgccaactg ttcagtgcac atgtgctgca   1140
 tcagaaatgg cacctggatg acagaagctc aaagagtcac atatgtctc               1189



      <210> 678
      <211> 886
      <212> DNA
      <213> Homo sapiens


      <400> 678
 tttttttttt ttgagagaac ctgaacattt aatatggtca gcaccttgta aggtgaaggt     60
 gtgtttttta cacaaattat aaataatgaa aaatatgcat ttagaaaaag aagcagcagt    120
 ccccttggcg ggccggctcg aggactcttt ggttgagtgg caggtgaggc cctgggtcca    180
 gggtctgtca gagcccccct aggtcatctg ccaggaaggc cagcaggtag cggctgacat    240
 gtctgtcgat gatgacaggc gagaaaccga ggacgcgccg ggtccctggc aggcccttgg    300
 ggtctggcgg atagcagtac aggagcaggg ccagtcccac agcaaggccc aggccagcca    360
 ggaagctcat gggtcccctg ttactcagct cgccgctctg gctgcccgag tctagctctg    420
 tgcaatctga gttctgcaga gcgtggcggc tgggcaggcg gctgtgcagg ggctgggcat    480
 ggatatacag ggctcggtag aactcctggc agtcccgctc accgctccgc tgcaggtggc    540
 tcaggaggtc acagagccgc acacgcaagg atgccttggg gttccggaac tcctcagcac    600
 cttttccgcc tccttgttgg taaggatctg tgggtagtaa cggttcagct ggaggatgat    660
 cctgtccacc tgctgctcac tcaagcgccc atggcctgtc aggaaaggcg tgtcctgcac    720
 caggcggtca caataggtct gatctgtcat ggcgacggac acagcgccgc ccgcagtccc    780
 cagcggtctg ccccgccgcg cgtccgcccc tcggtcagcc gcccggtcca ccagctccag    840
 cgaacgcccc cgcgggccgt gctcgcccgc cccttttggc taggcc                   886



      <210> 679
      <211> 1369
      <212> DNA
      <213> Homo sapiens


      <400> 679
 agttggcatc agtcgcagcc ctgttctccc tccttaccca ggggctccgc ctatgccaac     60
 atcatctccc agtttgcaca gaccggcttc ctccttctct acattgggct gaagaagctg    120
 cacctggaga cgtgggcagg gctgctcagt gtggtggatc tctctgccca ggctgtcatc    180
 tacgaggtgg ccactgtgac ctacatgatt cccttggggc tcagcatcgg ggtctgtgtc    240
 cgagtgggga tggctctggg ggctgcggat actgtgcagg ccaagcgctc ggccgtctcg    300
 ggcgtgctca gcatagttgg catttccctg gtcctgggca ccctgataag catcctgaaa    360
 aatcagctgg ggcatatttt taccaatgat gaagatgtca ttgccctggt gagccaggtc    420
 ttgccggttt atagtgtctt tcacgtgttt gaggccatct gttgtgtcta tggcggagtt    480
 ctgagaggaa ctgggaagca ggcctttggt gccgctgtga atgccatcac atattacatc    540
 atcggcctac cactgggcat ccttctgacc tttgtggtca gaatgagaat catgggcctc    600
 tggctgggca tgctggcctg tgtcttcctg gcaactgctg cctttgttgc ttatactgcc    660
 cggctggact ggaagcttgc tgcagaggag gctaagaaac attcaggccg gcagcagcag    720
 cagagagcag agagcactgc aaccagacct gggcctgaga aagcagtcct atcttcagtg    780
 gctacaggca gttcccctgg cattaccttg acaacgtatt caaggtctga gtgccacgtg    840
 gacttcttca ggactccaga ggaggcccac gccctttcag ctcctaccag cagactatca    900
 gtgaaacagc tggtcatccg ccgtggggct gctctggggg cggcgtcagc cacactgatg    960
 gtggggctca cggtcaggat cctagccacc aggcactagc aaagaagctt ggaaatagaa   1020
 agccaggagt ggctgtcccc agtatgcaaa cacaccacgg tctgccctgc aaaaacacca   1080
 atggggtcta gtgcaggtgg acactttgaa ccactcctca aaaaaagaac tttggctgat   1140
 tccttgtggt gacactcaga ggggtctgaa cagacttgac aattctgttc tggtcaagct   1200
 ggagttttct tctgtgactt ggactgctct acagaagaca tcagccaact gcacgagtca   1260
 gagtccaggg attgtcacta ttattaataa tgtaaatggc ttcaaatggg acacctgcag   1320
 ataaaatcac aaaaaccact gttatattaa agattacaca tttcctggg               1369



      <210> 680
      <211> 1369
      <212> DNA
      <213> Homo sapiens


      <400> 680
 agttggcatc agtcgcagcc ctgttctccc tccttaccca ggggctccgc ctatgccaac     60
 atcatctccc agtttgcaca gaccggcttc ctccttctct acattgggct gaagaagctg    120
 cacctggaga cgtgggcagg gctgctcagt gtggtggatc tctctgccca ggctgtcatc    180
 tacgaggtgg ccactgtgac ctacatgatt cccttggggc tcagcatcgg ggtctgtgtc    240
 cgagtgggga tggctctggg ggctgcggat actgtgcagg ccaagcgctc ggccgtctcg    300
 ggcgtgctca gcatagttgg catttccctg gtcctgggca ccctgataag catcctgaaa    360
 aatcagctgg ggcatatttt taccaatgat gaagatgtca ttgccctggt gagccaggtc    420
 ttgccggttt atagtgtctt tcacgtgttt gaggccatct gttgtgtcta tggcggagtt    480
 ctgagaggaa ctgggaagca ggcctttggt gccgctgtga atgccatcac atattacatc    540
 atcggcctac cactgggcat ccttctgacc tttgtggtca gaatgagaat catgggcctc    600
 tggctgggca tgctggcctg tgtcttcctg gcaactgctg cctttgttgc ttatactgcc    660
 cggctggact ggaagcttgc tgcagaggag gctaagaaac attcaggccg gcagcagcag    720
 cagagagcag agagcactgc aaccagacct gggcctgaga aagcagtcct atcttcagtg    780
 gctacaggca gttcccctgg cattaccttg acaacgtatt caaggtctga gtgccacgtg    840
 gacttcttca ggactccaga ggaggcccac gccctttcag ctcctaccag cagactatca    900
 gtgaaacagc tggtcatccg ccgtggggct gctctggggg cggcgtcagc cacactgatg    960
 gtggggctca cggtcaggat cctagccacc aggcactagc aaagaagctt ggaaatagaa   1020
 agccaggagt ggctgtcccc agtatgcaaa cacaccacgg tctgccctgc aaaaacacca   1080
 atggggtcta gtgcaggtgg acactttgaa ccactcctca aaaaaagaac tttggctgat   1140
 tccttgtggt gacactcaga ggggtctgaa cagacttgac aattctgttc tggtcaagct   1200
 ggagttttct tctgtgactt ggactgctct acagaagaca tcagccaact gcacgagtca   1260
 gagtccaggg attgtcacta ttattaataa tgtaaatggc ttcaaatggg acacctgcag   1320
 ataaaatcac aaaaaccact gttatattaa agattacaca tttcctggg               1369



      <210> 681
      <211> 445
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(445)
      <223> n = a,t,c or g


      <400> 681
 gcggtcaccc caatacggat aacgngacac gagcggagca gccctggggt cacctatcag     60
 taaaagacta tttgtttttt tcctcgtctt actggatgtc actctcgggc ttgccgacct    120
 aattttcact gacagcaaac tttatattcc tttggagtat cgttctattt ctctagccat    180
 tgccttattt tttctcatgg atgttcttct tcgagtattt gtaaaagggt gttggagcgg    240
 gccggagaga agtagagtgg gctgcgagga gaaggaaaca ggcctttcgg aggctcctca    300
 tccctcggag ggcatccctt actccagcaa gagtgagcca tggagctacg tgtggggaac    360
 aagtaccgcc tgggacggaa gatcgggagc gggtccttcg gagatatcta cctgggtgcc    420
 aacatcgcct ctggtgagga agtcg                                          445



      <210> 682
      <211> 3864
      <212> DNA
      <213> Homo sapiens


      <400> 682
 cagagaacgt ttgtctgcct gatgagagcc acttgggtta agaaactacc tgtgaatagt     60
 catcatttct gtccttcatt ggggaatact tttagaggcc agtttccaaa aattctgctt    120
 aaaaaagaat tctggttttg tcttactctt ccagatgaga tatcacagag gcttgggcct    180
 agattgtcat cagcatactg ctatactatt cgtttgttct tattaagcct tattgtgtgt    240
 aatgctgtta ctttttcaga gtgttgcgga gataggaaca tgggagagaa acaatctggg    300
 taacatgaaa gtgatgctgg ttgctaaggg aaggcaactt gattctgtgg gaagggctgt    360
 agctgatcca tccgttgtct agatttgagt atgagcacag tggaagagga ttctgacaca    420
 gtaacagtag aaactgtgaa ctctgtgact ttgactcagg acacagaagg gaatctcatt    480
 cttcactgcc ctcagaatga agcggatgaa atagactcag aagatagtat tgaacctcca    540
 cataaaaggc tttgtttgtc ctctgaggat gatcagagta ttgatgattc tactccttgc    600
 atatcagttg ttgcacttcc actttcagaa aatgatcaga gctttgaagt gaccatgact    660
 gcgaccacag aagtagcaga tgatgaggtt actgagggga ctgtgacaca gatacagatt    720
 ttgcagaatg agcaactaga tgaaatatct cccttgggta acgaggaagt ttcagcagtt    780
 agccaagcat ggtttacaac taaagaagat aaggattctc tgactaataa aggacataaa    840
 tggaagcagg ggatgtggtc caaggaagaa attgatattt tgatgaacaa tattgaacgc    900
 tatcttaagg cacgcggaat aaaagatgct acagaaatca tctttgagat gtcaaaagac    960
 gaaagaaaag atttctacag gactatagca tggggtctga accggccttt gtttgcagtt   1020
 tatagaagag tgcttcgcat gtatgatgac agaaaccatg tgggaaaata tacacctgaa   1080
 gaaattgaga agctcaagga gctccggata aagcatggca atgactgggc aacaataggg   1140
 gcggcgctag gaagaagtgc atcttctgtc aaagatcggt gccgactgat gaaggatact   1200
 tgcaacacag ggaagtggac agaagaagaa gaaaagagac ttgcagaagt ggttcatgag   1260
 ttgacaagca ctgagcccag gtgacatagt cacacagggt gtgtcttggg cagctgtggc   1320
 tgaacgagtc ggtacccgct cagaaaagca atgtcgttct aaatggctca actacctgaa   1380
 ttggaaacag agtgggggta ctgaatggac caaggaagat gaaatcaatc tcatcctcag   1440
 gatagcagaa cttgatgtag ctgatgaaaa tgacattaac tgggatctgt tagctgaggg   1500
 atggagtagt gtccgttcac cacaatggct acgaagtaaa tggtggacca tcaaaaggca   1560
 aattgcaaac cataaggatg tttcgttccc tgtcttaata aaaggtctta aacagttaca   1620
 tgagaaccaa aaaaacaacc caacgctttt ggagaataaa tcaggatctg gagttccaaa   1680
 cagtaatacc aattccagtg tgcagcatgt tcagataaga gttgcccgct tggaagataa   1740
 tacagccatc tcttctagcc ccatggcagc attgcagatt ccagtccaga tcacccatgt   1800
 ttcttcagca gactctcctg ctaccgttga ctcagaaaca ataacactaa acagtggaac   1860
 actacagaca tttgagattc ttccctcttt ccatctacag cccactggca ctccaggcac   1920
 ctacctactt caaacaagct caagccaagg ccttccccta actctgactg ctagtcccac   1980
 agtaaccctg acagctgctg ctcctgcttc tcctgaacag attattgttc atgctttatc   2040
 cccagaacat ttgttgaaca caagtgataa tgttacaggt gcagtgtcac acaccaagag   2100
 tcatcattca gactgttgcc acagaggaca tcacttcttc catatcccaa ggcaggaact   2160
 gaccgtcgat agtgatattc agttcattct ggattttcct gagcctccag acgccctaga   2220
 aggcaaacac tttcccagat gaaattcatc accctaagat gactgtggag ccatcattta   2280
 atgatgctca tgtatccaaa ttcagtgacc aaaatagcac agaactgatg aatagtgtta   2340
 tggtcagaac agaaaaagaa atctctgaca ccgaccttaa acaagaggaa tcaccctctg   2400
 atttagccag tgcttatgtt actgagggtt tagagtctcc cactatagaa gaacaagttg   2460
 atcaaacaat tgatgatgaa acaatactta tcgttccttc accacatggc tttatccagg   2520
 catctgatgt tatagatact gaatctgtct tgcctttgac aacactaaca gatcccatac   2580
 tccaacatca tcaggaagaa tcaaatatca ttggatcatc cttgggcagt cctgtttcag   2640
 aagattcaaa ggatgtcgaa gatttggtaa actgtcatta gaataattct tagaaatagg   2700
 cagttcaagc aaagaaggca cactgttaat tacaacctct tcaaagaaat aggagcaacc   2760
 cccaagaggc ttaatttacc aatttaaata gccacagtcc ttaagccaca cacattgttg   2820
 ctgctatgac tttttacctc ctttaaacac atcatctgag gttgagtttt atgacagtat   2880
 gtagttgagt ggaggctggg agttttaagc ataaatccct gtttagtgtt acatgggaat   2940
 aaggaatttc attcacttca gccactaaga aaagtttaga atcacgaaag cttaactgct   3000
 gtggtttaaa gtacagtttc tctaaagatc agacatggca ctgtctcctc tcaagcctgg   3060
 ttgtagttca gatgagtctt ttcaacatgg tcttcaacat ggtctagagc ttaccagtga   3120
 tcttctgatc ttcaagaaga ctaagtttga gacttgacca gcatacaagt atagagacct   3180
 aggaggtggt cttgtggtgg tacatttggt taacccattg ctggcagtgg gagctgattt   3240
 aggcagggta aacaggaaag cattaaaagt taaaattcac tacaggtttt ttgttacttt   3300
 taaagggaat atggataagc atagtaacaa aacccaccag aatctaagca gttttcaccc   3360
 cctcagaaac cactgtcatt agtttacaaa gttagcactt tgaagtaaaa ctaaatgagg   3420
 aaggaagtaa tgttacctat ccttgatacc atgaccattt attagatgtt ttgctatata   3480
 aattaccgag agaatagttt gtcatccact tagtgtgtta gctggtgggg tacaatataa   3540
 cctctcatct caggctattt taaaaaaaca atatttgctt ctataacaaa aggaaacaaa   3600
 tctaagaatc attcctgtac tacagaaggg ttaaggcaaa ggtagccttt tgggcttttt   3660
 aatgaatatg acccctatag aaaagtcaag aaaaaaaaac ccttgtataa attattttat   3720
 ttattattgt aattagatct tcacaaagtt gtcttttcac tgtgttttgt caacgtgaaa   3780
 ttaaattgta gttataagca aaagttggtt gcctagggaa caattgtata ttcagtttaa   3840
 cagaaataaa agaatatttg tctt                                          3864



      <210> 683
      <211> 704
      <212> DNA
      <213> Homo sapiens


      <400> 683
 agcgtggtgg aattcccgcg ggtaaggccc tccctagacc ctttatacct actttacctt     60
 tcggaggtca agacacctcc tgttgccgcc tcctcgccca acacacaggc gccccccgca    120
 cgggtaccaa gcttgactaa cggcctctag gggtgtgtgg tgggacttga aatcctccct    180
 taatgaagtc acaccttctc cgtccgcttc cacccggtcg gcccatggca gagcccccat    240
 gtagcccagg aatcggcttg gcccttcggg gaggtcagcg tccttactat ccccactctc    300
 cagtgcggca cattcgttcc cctaggactc cggccggttg ccggccccag gcggtgcttc    360
 tccccaccac cgcccagctc agctcagccc agcccagccc actctgccct tagaggccct    420
 tctccccaaa gacgcactcc agaagtctcg ccctcgtgcg gctgaggagc ctgggatccc    480
 agacctgaac aaggtgagca tccctatatt ttagcccaga aagatctgtg tggctcactt    540
 gccggcctcg ttctgtcaca cagagtccag atttagcctt gagttttcct agtgaaagac    600
 agaccctggt atcactatga ccctcctcag gctttcttac cccgcctcag aaagcagtga    660
 ggtgtctgct ttctcccagg gcttctttag ataggggtct taac                     704



      <210> 684
      <211> 617
      <212> DNA
      <213> Homo sapiens


      <400> 684
 ctcttctacg tctgaatgat ataagtgcag gggatcgcat acctgcttgg acatttgata     60
 tgaacacagg tgcttgggta aatcatggtc ggggaatggt caaggaacat aacaatcatt    120
 taatctggac atatgatgca ccacatttgg ggtactggat agcagctcca cttccaggaa    180
 ctagaggttc aggtataaat gaagattcca aggacataac tgcctaccac acagtgtttc    240
 ttacagccat attaggagga acaatagtca ttgtcattgg attttttgct gtactacttt    300
 gttattgcag ggacaagtgt ggtactccac agaaaagaga aagaaatatc actaaacttg    360
 aggtcctcaa gagagaccag acaacttcaa caacacacat aaatcatatc agtacagtta    420
 aagttgcatt aaaagctgag gacaagtcgc agttattcaa tgccaaaaac tcctcatata    480
 gtcctcagaa aaaggaacca tcaaaggcag aaacagaaga aagagtttcc atggtaaaaa    540
 ctcgggacga ttttaaaatc tacaatgaag atgtttcatt tctatcagtc aatcaaaata    600
 attactcaag aaacccc                                                   617



      <210> 685
      <211> 746
      <212> DNA
      <213> Homo sapiens


      <400> 685
 gtgggctgaa gctgcgcaag tcggagtcca agagcagcct ggccagccaa cgcagcaagc     60
 agagctcctt tcgcagcgag gcgggcatga gcaccgtcag ctccacggcc agcgacatcc    120
 actccaccat cagcctgggc gaggctgagg ccgagctggc ggtcatcgag gacgacatcg    180
 acgccaccac caccgagacc tacgtgggcg agtggaagaa cgacaaacgc tccggcttcg    240
 gcgtgagcca gcgctcggac gggctcaagt acgagggcga gtgggccagc aaccggcgcc    300
 atggctacgg ctgcatgacc ttcccggacg gcaccaagga ggagggcaag tacaagcaga    360
 acatcctcgt cggcggcaag cgcaagaacc tcatccccct gcgggccagc aagatccgcg    420
 agaaggtgga ccgcgccgtt gaggccgctg agcgggccgc caccatcgcc aagcagaagg    480
 ctgagatcgc ggcttccagg acctcccact ctcgggcaaa ggccgaggca gccctcacag    540
 cagcttagaa agcccaggag gaggcgcgga tcgcccagga tcactgccaa agagttctcc    600
 ccttccttcc agcaccggga aaacgggctg gagtaccaga ggccgaagcg tcagacctcc    660
 tgtgacgaca tcgaggtgct gtccaccggg acacccctgc agcaggagag ccccgagctg    720
 taccgcaagg gcaccactcc ctccga                                         746



      <210> 686
      <211> 593
      <212> DNA
      <213> Homo sapiens


      <400> 686
 catcgatgac cttactcagt gtggtggaat tccaggttca aagcctgaga ccaaagagct     60
 gcaggatttg aatccatatt tccaggggta actattaata aaaatgtagc ttggataaat    120
 tacatctatt ataaccagca gtggtttatt aattacacca gggatgctat caaaggaata    180
 gctgaccaat tagggcctac tagccaaatg gcttgggaaa acagaatggc cctagacatg    240
 atattagcca aaaaaggtgg agtttgtgtt atgatcaaaa ctcaatgttg taccttcatc    300
 ccaaacaata ctgcccctag tgggagcata acaagggcct tacaaggcct tactgcttta    360
 tccaatgaat tagctaaaaa ttctggagtc aatgaccctt tttcaggatg gctagaaagg    420
 tggtttggta aatggaaagg aatcatagcc tcaattctta cttctcttgc agccgtaata    480
 ggtgtagcca ttctttttgg gtgttgtgtc acaccatgta tccgtgggct agtacagagg    540
 cttatagaaa cagtacttac taaaacctcc cttagctctc ctccacctta tta           593



      <210> 687
      <211> 1641
      <212> DNA
      <213> Homo sapiens


      <400> 687
 gcggccgctg ctcactgacc tctaccaggc caccatggcg ttgggctatt ggcgcgcggg     60
 ccgggcgcgg gacgccgccg agttcgagct cttcttccgc cgctgcccgt tcggcggcgc    120
 cttcgccttg gccgccggct tgcgcgactg tgtgcgcttc ctgcgcgcct tccgcctgcg    180
 ggacgccgac gtgcagttcc tggcctcggt gctgccccca gacacggatc ctgcgttctt    240
 cgagcacctt cgggccctcg actgctccga ggtgacggtg cgagccctgc ccgagggctc    300
 cctcgccttc cccggagtgc cgctcctgca ggtgtccggg ccgctcctgg tggtgcagct    360
 gctggagaca ccgctgctct gcctggtcag ctacgccagc ctggtggcca ccaacgcagc    420
 gcggcttcgc ttgatcgcag ggccagagaa gcggctgcta gagatgggcc tgaggcgggc    480
 tcagggcccc gatgggggcc tgacagcctc cacctacagc tacctgggcg gcttcgacag    540
 cagcagcaac gtgctagcgg gccagctgcg aggtgtgccg gcggccggga ccctggccca    600
 ctccttcgtc acttcctttt caggcagcga ggtgccccct gacccgatgt tggcgccagc    660
 agctggtgag ggccctgggg tggacctggc ggccaaagcc caggtgtggc tggagcaggt    720
 gtgtgcccac ctggggctgg gggtgcagga gccgcatcca ggcgagcggg cagcctttgt    780
 ggcctatgcc ttggcttttc cccgggcctt ccagggcctc ctggacacct acagcgtgtg    840
 gaggagtggt ctccccaact tcctagcagt cgccctggcc ctgggagagc tgggctaccg    900
 ggcagtgggc gtgaggctgg acagtggtga cctgctacag caggctcagg agatccgcaa    960
 ggtcttccga gctgctgcag cccagttcca ggtgccctgg ctggagtcag tcctcatcgt   1020
 agtcagcaac aacattgacg aggaggcgct ggcccgactg gcccaggagg gcagtgaggt   1080
 gaatgtcatt ggcattggca ccagtgtggt cacctgcccc caacagcctt ccctgggtgg   1140
 cgtctataag ctggtggccg tggggggcca gccacgaatg aagctgaccg aggaccccga   1200
 gaagcagacg ttgcctggga gcaaggctgc tttccggctc ctgggctctg acgggtctcc   1260
 actcatggac atgctgcagt tagcagaaga gccagtgcca caggctgggc aggagctgag   1320
 ggtgtggcct ccaggggccc aggagccctg caccgtgagg ccagcccagg tggagccact   1380
 actgcggctc tgcctccagc agggacagct gtgtgagccg ctcccatccc tggcagagtc   1440
 tagagccttg gcccagctgt ccctgagccg actcagccct gagcacaggc ggctgcggag   1500
 ccctgcacag taccaggtgg tgctgtccga gaggctgcag gccctggtga acagtctgtg   1560
 tgcggggcag tccccctgag actcggagcg gggctgactg gaaacaacac gaatcactca   1620
 cttttcccca caaaaaaaaa a                                             1641



      <210> 688
      <211> 1641
      <212> DNA
      <213> Homo sapiens


      <400> 688
 gcggccgctg ctcactgacc tctaccaggc caccatggcg ttgggctatt ggcgcgcggg     60
 ccgggcgcgg gacgccgccg agttcgagct cttcttccgc cgctgcccgt tcggcggcgc    120
 cttcgccttg gccgccggct tgcgcgactg tgtgcgcttc ctgcgcgcct tccgcctgcg    180
 ggacgccgac gtgcagttcc tggcctcggt gctgccccca gacacggatc ctgcgttctt    240
 cgagcacctt cgggccctcg actgctccga ggtgacggtg cgagccctgc ccgagggctc    300
 cctcgccttc cccggagtgc cgctcctgca ggtgtccggg ccgctcctgg tggtgcagct    360
 gctggagaca ccgctgctct gcctggtcag ctacgccagc ctggtggcca ccaacgcagc    420
 gcggcttcgc ttgatcgcag ggccagagaa gcggctgcta gagatgggcc tgaggcgggc    480
 tcagggcccc gatgggggcc tgacagcctc cacctacagc tacctgggcg gcttcgacag    540
 cagcagcaac gtgctagcgg gccagctgcg aggtgtgccg gcggccggga ccctggccca    600
 ctccttcgtc acttcctttt caggcagcga ggtgccccct gacccgatgt tggcgccagc    660
 agctggtgag ggccctgggg tggacctggc ggccaaagcc caggtgtggc tggagcaggt    720
 gtgtgcccac ctggggctgg gggtgcagga gccgcatcca ggcgagcggg cagcctttgt    780
 ggcctatgcc ttggcttttc cccgggcctt ccagggcctc ctggacacct acagcgtgtg    840
 gaggagtggt ctccccaact tcctagcagt cgccctggcc ctgggagagc tgggctaccg    900
 ggcagtgggc gtgaggctgg acagtggtga cctgctacag caggctcagg agatccgcaa    960
 ggtcttccga gctgctgcag cccagttcca ggtgccctgg ctggagtcag tcctcatcgt   1020
 agtcagcaac aacattgacg aggaggcgct ggcccgactg gcccaggagg gcagtgaggt   1080
 gaatgtcatt ggcattggca ccagtgtggt cacctgcccc caacagcctt ccctgggtgg   1140
 cgtctataag ctggtggccg tggggggcca gccacgaatg aagctgaccg aggaccccga   1200
 gaagcagacg ttgcctggga gcaaggctgc tttccggctc ctgggctctg acgggtctcc   1260
 actcatggac atgctgcagt tagcagaaga gccagtgcca caggctgggc aggagctgag   1320
 ggtgtggcct ccaggggccc aggagccctg caccgtgagg ccagcccagg tggagccact   1380
 actgcggctc tgcctccagc agggacagct gtgtgagccg ctcccatccc tggcagagtc   1440
 tagagccttg gcccagctgt ccctgagccg actcagccct gagcacaggc ggctgcggag   1500
 ccctgcacag taccaggtgg tgctgtccga gaggctgcag gccctggtga acagtctgtg   1560
 tgcggggcag tccccctgag actcggagcg gggctgactg gaaacaacac gaatcactca   1620
 cttttcccca caaaaaaaaa a                                             1641



      <210> 689
      <211> 1641
      <212> DNA
      <213> Homo sapiens


      <400> 689
 gcggccgctg ctcactgacc tctaccaggc caccatggcg ttgggctatt ggcgcgcggg     60
 ccgggcgcgg gacgccgccg agttcgagct cttcttccgc cgctgcccgt tcggcggcgc    120
 cttcgccttg gccgccggct tgcgcgactg tgtgcgcttc ctgcgcgcct tccgcctgcg    180
 ggacgccgac gtgcagttcc tggcctcggt gctgccccca gacacggatc ctgcgttctt    240
 cgagcacctt cgggccctcg actgctccga ggtgacggtg cgagccctgc ccgagggctc    300
 cctcgccttc cccggagtgc cgctcctgca ggtgtccggg ccgctcctgg tggtgcagct    360
 gctggagaca ccgctgctct gcctggtcag ctacgccagc ctggtggcca ccaacgcagc    420
 gcggcttcgc ttgatcgcag ggccagagaa gcggctgcta gagatgggcc tgaggcgggc    480
 tcagggcccc gatgggggcc tgacagcctc cacctacagc tacctgggcg gcttcgacag    540
 cagcagcaac gtgctagcgg gccagctgcg aggtgtgccg gcggccggga ccctggccca    600
 ctccttcgtc acttcctttt caggcagcga ggtgccccct gacccgatgt tggcgccagc    660
 agctggtgag ggccctgggg tggacctggc ggccaaagcc caggtgtggc tggagcaggt    720
 gtgtgcccac ctggggctgg gggtgcagga gccgcatcca ggcgagcggg cagcctttgt    780
 ggcctatgcc ttggcttttc cccgggcctt ccagggcctc ctggacacct acagcgtgtg    840
 gaggagtggt ctccccaact tcctagcagt cgccctggcc ctgggagagc tgggctaccg    900
 ggcagtgggc gtgaggctgg acagtggtga cctgctacag caggctcagg agatccgcaa    960
 ggtcttccga gctgctgcag cccagttcca ggtgccctgg ctggagtcag tcctcatcgt   1020
 agtcagcaac aacattgacg aggaggcgct ggcccgactg gcccaggagg gcagtgaggt   1080
 gaatgtcatt ggcattggca ccagtgtggt cacctgcccc caacagcctt ccctgggtgg   1140
 cgtctataag ctggtggccg tggggggcca gccacgaatg aagctgaccg aggaccccga   1200
 gaagcagacg ttgcctggga gcaaggctgc tttccggctc ctgggctctg acgggtctcc   1260
 actcatggac atgctgcagt tagcagaaga gccagtgcca caggctgggc aggagctgag   1320
 ggtgtggcct ccaggggccc aggagccctg caccgtgagg ccagcccagg tggagccact   1380
 actgcggctc tgcctccagc agggacagct gtgtgagccg ctcccatccc tggcagagtc   1440
 tagagccttg gcccagctgt ccctgagccg actcagccct gagcacaggc ggctgcggag   1500
 ccctgcacag taccaggtgg tgctgtccga gaggctgcag gccctggtga acagtctgtg   1560
 tgcggggcag tccccctgag actcggagcg gggctgactg gaaacaacac gaatcactca   1620
 cttttcccca caaaaaaaaa a                                             1641



      <210> 690
      <211> 594
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(594)
      <223> n = a,t,c or g


      <400> 690
 attcggcaca gggccgagga ctgctccggc cgcaccatgc nccagctggc cattgagatc     60
 ggggtgcgag ccctgctctt cggagtcttc gtttttacag agtttttgga tccgttccag    120
 agagtcatcc agccagaaga gatctggctc tataaaaatc ctttggggca atcagataac    180
 atacctaccc gcctcatgtt tgcaatttct ttcctcacac ccctggctgt tatttgtgtg    240
 gtgaaaatta tccggcgaac agacaagact gaaattaagg aagccttctt agcggtgtcc    300
 ttggctcttg ctttgaatgg agtctgcaca aacactatta aattaatagt gggaagacct    360
 cgccccgatt tcttttaccg ctgctttcca gatggagtga tgaactcgga aatgcattgc    420
 acaggtgacc ccgatctggt gtccgagggc cgcaaaagct tccccagcat ccattcctcc    480
 tttgcctttt cgggccttgg cttcacgacg ttctacttgg cgggcaagct gcactgcttc    540
 accgagagtg ggcggggaaa gagctggcgg ctctgtgctg ccatcctgcc cttg          594



      <210> 691
      <211> 1011
      <212> DNA
      <213> Homo sapiens


      <400> 691
 cgggctggaa cagagcagcc ggcctctgtc ctaagactgg ccacgctgag acggacaggc     60
 agcaggggag cgaccggagc tggggcgctg gatgtgggga aagggagaga ggtgttaggg    120
 aggcccccag tctcgggccc aggttacaag gtcttaccct ggggtgggaa cccaggaggt    180
 ggagtggctg gggggcacag ctgagaagtt caggaagatg gaggatgagg attcccaggt    240
 tcctccctgt ccatgtcagg gtgaggggtg caggagcaca gaggccatgc tctgccatgg    300
 ctggggactt ccttgtgaat actgcagccc tagggctgca aggggacacc acgcacagag    360
 acacggcagg ccccgtgttg gccgggggtg ggggtgaggg cagaaccagc cgagggacgc    420
 tgagtcagac cgcttgccca ctgctctggt gcagggacct ggctgcaggt gctggagacc    480
 atcggtgtgc tggcggtcat tgccaatggg atggtcattg ccttcacatc tgagttcatc    540
 ccccgagtgg tctacaagta ccgctatagc ccatgcctga aagaaggcaa ctctactgtc    600
 gactgcctca agggctacgt caaccacagc ctgtccgtct tccacaccaa ggacttccag    660
 gaccctgatg ggattgaggg ctcagaaaac gtgactctgt gcaggtttgg aactccccat    720
 cccccaagaa tgccctctga actcctgacc cctgacctca ggtacttcct taccccagat    780
 acagggacta ccgcaatccc cccgattaca acttctccga gcagttctgg ttcctcctgg    840
 ccatccgcct ggccttcgtc atcctctttg agcacgtggc cttgtgcatc aagctcatcg    900
 ccgcctggtt cgtgcccgac atccctcagt cggtgaagaa caaggttctg gaggtgaagt    960
 accagaggct gcgtgagaag atgtggcatg gaaggcacag gcatgcgttg g            1011



      <210> 692
      <211> 1376
      <212> DNA
      <213> Homo sapiens


      <400> 692
 tttcgtctgc tcggcgtcgt ggccttcagc acgttaatgc tcaaacgctt cagagaacca     60
 aagcatgaaa gacgtccgtg gaggatatgg tttttagaca cttccaaaca agccatagga    120
 atgctgttca tccactttgc aaatgtatac ctagcagatc tcactgaaga ggacccttgt    180
 tcactgtacc tcatcaactt cctcctggac gccactgtgg gcatgctgct catctacgtg    240
 ggggtgcgcg ccgtcagcgt cctggtagag tggcagcagt gggagtccct gcgcttcggc    300
 gaatatggag accctctgca gtgtggagcc tgggtcgggc agtgcgctct ttacatcgtg    360
 atcatgattt ttgaaaagtc tgtcgtcttc atcgtcctcc taatacttca gtggaaaaag    420
 gtggccctgt tgaatcccat tgaaaaccca gacttgaagc tggccatcgt catgctgatc    480
 gtccccttct ttgtcaacgc tttgatgttt tgggtagtgg acaatttcct catgagaaag    540
 gggaagacga aagctaagct agaagaaagg ggagccaacc aggactcgag gaatgggagc    600
 aaggtccgct accggagggc cgcatcccac gaggagtctg agtctgagat cctgatctca    660
 gcggatgatg agatggagga gtccgacgtg gaggaggacc tccgcagact gacccccctc    720
 aagcctgtga agaaaaagaa gcaccgcttt gggctacccg tatgacacat tcccatgctg    780
 ggggtgacgg gagggccccg ccaaccgctg gtgtgcagag gtcatcccgc agcatcgttc    840
 cttaccctct ctctgccctt cctttctacc tctgctcctc ttgctgtctc tgcccgctct    900
 cgcctgcccc cagactactg tgacttaaaa agagggaaga ggagccagcg cccgaggggg    960
 ccactggcgg ctggaggtcc ccattcagtt gcactacaaa cactgaccaa atatgcaagg   1020
 aaggagctgt gtttgtttgt tgtcgtccca gacagtgttg tgagggacct gaggccctgc   1080
 cccgtgtccg accaccgagt ggcaaggtgg aaggaagcac aggcacacag accgtgggtg   1140
 ggtctcctca ccgtggctgt gggcagtgcg aacacataac accctcgggc taaaagtgac   1200
 tcgttgacca agttggaacc ggaatgcttt cttactcaaa atggcttttg taactattga   1260
 tttctgaagc tggttttatg agttgtgaca gtgttaccag gttgggggta tgtgtttatt   1320
 tcctacaaag tacttacggg actaatgggc aaaacagaga tttttaagtc ttccgt       1376



      <210> 693
      <211> 1221
      <212> DNA
      <213> Homo sapiens


      <400> 693
 gggtggaatt cgggcagcct gcgcctgggt accgaggctg ctgcgcggcg gacagcgggc     60
 gcgatgtatc tccgcagggc ggtctccaag actctggcgc tgccgctgag ggcgcccccc    120
 aaccccgcgc cgctcggaaa ggacgcatct ctgcgccgga tgtcatctaa cagattccct    180
 ggatcatctg gatcaaatat gatttattat ctggttgtag gcgtcacagt cagtgctggt    240
 ggatattatg cttacaagac agtcacatca gaccaagcca aacacacaga acataaaaca    300
 aatttgaaag aaaaaacaaa agcagagata catccatttc aaggtgaaaa ggagaatgtt    360
 gcggaaactg agaaagcaag ttcagaagcc ccagaagaac ttatagtgga agctgaggtg    420
 gtagatgctg aagaaagtcc cagtgctaca gttgtggtca taaaagaggc atctgcctgt    480
 ccaggtcacg tggaggctgc tccggagacc acagcagtca gtgctgaaac cgggccagag    540
 gtcacagatg cagcggcgag ggaaaccacg gaagtaaacc ctgaaacaac cccagaggtt    600
 acaaatgctg ccctggatga agctgtcacc atcgataatg ataaagatac aacaaagaac    660
 gaaacctctg atgaatatgc tgaactagaa gaagaaaatt ctccagctga gtcagagtcc    720
 tctgctggag atgatttaca ggaggaagcc agtgttggct ctgaggctgc ttcggctcaa    780
 ggctaatctc cagccggtag acatttcagc aacaaatgcc atagggtgtc tgataagtgc    840
 ttttgtgttt ttagtacact tagtttaaaa aaaaaaagac ttattttcta gaaaacgtta    900
 atgggtcttg aagatttttg gcatccactg atagatttta ggactgagag acttgagatt    960
 gtacatttct tactactctt ctactgtctg agatcagaat atgacattgc agtaaagagc   1020
 ttaaatagtt tcatctttgg tttttttttc tagacacttt tcttttatcc cagtcatctc   1080
 tgaatttaca ttttatatta aagaaattga gctatccata caacctgtat ttactttaat   1140
 ttcactactg tttcagctta ctttattgta tgatatgtag gtctaaaata tagtttgagt   1200
 caaataaaat tagaaactgc t                                             1221



      <210> 694
      <211> 2077
      <212> DNA
      <213> Homo sapiens


      <400> 694
 tttcgtctaa cctcggctct tcccagtcct ctggactata atggggaaca cattgggcct     60
 ggcaccaatg gggactttgc cccgccggag cccccgccga gaggaacccc tgcccaaccc    120
 tgggagcttc gatgagctgc accgtctatg caaagatgta ttcccagcac agatggaggg    180
 agtgaagctc gttgtcaaca aggttctgag cagccatttc caggtggcgc acactataca    240
 catgagtgcc ctgggcttgc cgggatatca cctccatgcg gcctatgcag gggattggca    300
 gctcagtccc actgaggtgt tccccactgt ggtaggggat atggacagca gtggcagcct    360
 gaacgcccag gtcttgctcc tcttggcaga gcggctccga gctaaggctg tcttccagac    420
 gcagcaggcc aagttcctga catggcagtt tgatggcgag tatcggggag atgactacac    480
 agccactctg accctaggaa atcctgacct gattggggag tcggtgatca tggttgctca    540
 cttcctgcag agcctcactc atcggctggt gctgggagga gagctagttt atcaccggcg    600
 gccaggcgaa gagggggcca tcttgacact ggctgggaag tactcggctg tacactgggt    660
 agctacattg aatgtgggat caggcggggc ccatgcaagt tactaccaca gggcaaatga    720
 acaggttcag gttggagtgg agtttgaggc aaacacaagg ctacaagaca caacattctc    780
 ctttggttac cacctgactc tgccccaggc caacatggta tttagaggct tggtggatag    840
 taactggtgt gtaggtgctg tgctggagaa gaagatgccc cctctgcctg tcaccctagc    900
 ccttggagcc ttcctcaatc actggcgcaa cagattccat tgtggcttca gcatcactgt    960
 gggctgaggt tgtccagagc cagcccccac agcagctgga acctctgagt caggtgccct   1020
 agggccaaag actaggcccc tcttcagagc ccaccttgct gggtgatctc taggacccag   1080
 gagcagagtg gtggacagga ccatgccctc ctcagaactg gagctgccac aggggcagtt   1140
 gatgaggcag aggtttgagg atcccccctc tgctaccagc cccagtatca ccttccccat   1200
 gctcttgtgg ctgtggacta agggagaagg attaaggggt atggctgaat tcccccggca   1260
 ccccttgccc tcaggcttcc ttcttccttt ccctttggtt aatcctgcat gggattagct   1320
 gaccatcctg ttttccatcc cagagcctcc caaggctggg aaagtagggc tgaagggcta   1380
 gatgtttggt ctcaggaagt ggggcccacc cattcccaga aggagcttct ttacctctta   1440
 gccctgaggt ttcctccttc ccatcttctg tgcttccaga gaacaacttt gttcctatgg   1500
 tcacccccac tatccccatg accgcatgaa gaggcagtta ttgctttagt ctttcattgc   1560
 aaccactggg ctccctttga acccggccca atctttggtc ccagcatttt cccactccag   1620
 tgtatccagg gtgttccagg tgagctgggg aaggaagtga gcatggcctc agctgcagat   1680
 ctcctggagc agcggcatca tggcagacag gccctggatg tgctggattt ggtacccgta   1740
 ggcctcatta atgctccgga gctcagccag caggcctagc aacttcgcat acagaaacct   1800
 ttggaggaag tagtggggtt gccaggaaaa caggagggaa ataaggcagt tgggagtctt   1860
 gtctctaggc cctgatcccc tgaactattc ctcagtgaag ccaggtctga acattataga   1920
 aaatcatgct ctggtatgac agactatcag aggttccaaa ggtcctccag ggggcctcgg   1980
 tctgacactg tcttctctca ccatgctcag ttttttctga acccagagct ctgagagccg   2040
 agtgtgaaga aagctccaga cttggccaga acctcac                            2077



      <210> 695
      <211> 446
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(446)
      <223> n = a,t,c or g


      <400> 695
 tttcgtggag ggtccccata ttgcccatca ggcagcggct gttcctgttt ccccgagggc     60
 tcggaggtac tgaaggtggt cgccatggat ggagaccggg gcaaacccaa tcgaattctc    120
 tacagccttg taaatgggaa cgatggagcc tttgaaatta atgagacatc tggagccatc    180
 tccatcactc agagcccggc ccagctccag agagaggtgt atgagctgca tgtacaggtg    240
 actgaaatga gccctgcggg gagcccagct gcccaggcca ccgtcccagt caccatcagg    300
 attgtggacc tcaacaacca cccgccaaca ttctatggag agagcggacc ccaaaacagg    360
 tttgagctgt ccatgaatga gcacccaccc cagggagaga tcctgcggng cctcaagatc    420
 accgtcaatg actccgacca gggaaa                                         446



      <210> 696
      <211> 1337
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1337)
      <223> n = a,t,c or g


      <400> 696
 tttcgtggtg actccagcgg aggagctctg ggacaccctt gtctagggaa gaggtcttac     60
 tggctgccct cacctgactt tgtgtcccca ggcccccagc catggccctg tccctgcctc    120
 tgggccctag acttggctca gagcccctca accacccacc gggagcacct agagaggcgg    180
 acattgttgg atgcaccgtc tgccccgcgt ccggagagga gagcacgagc ccagagcagg    240
 cccagaccct gggacaggac tccttgggcc ctcctgagca cttccagggt gggccaaggg    300
 gcaatgagcc tgccgctcac cccccgagat ggtcaacacc ctcttcctac gaggacccag    360
 ctgggggcaa acactgtgag caccccattt ctggcctgga ggtactagag gctgagcaga    420
 acagcctgca cctgtgcctg ctggggctgg gccgccggct gcaggacctg gagcaaggcc    480
 tggggcactg ggcattggcc cagagtggga tggtgcagct gcaggccctc caggtggacc    540
 tacgaggggc agctgagcgt gtggaggcgc tgctagcgtt tggtgagggg ctggcacagc    600
 ggagtgagcc cagggcctgg gcagccctgg agcagatcct gcgggccctg ggagcttacc    660
 gagactccat cttccggcgg ctctggcagc tgcaggccca gctggtcagc tacagcctgg    720
 tgttcgagga ggccaacacg ctggaccagg acttggaggt cgagggagac tcggactggc    780
 caggacctnc gtggggtctg ggggccctgg gcacccagta gcctccccac ttccacagag    840
 ttggagtggg atccggcggg ggacattggg ggccttgggc ccttgggaca aaagacagcc    900
 cggacactag gagtgccctg tgagctgtgt ggccacaggg ggccccaggg caggggacaa    960
 ggccttgagg tgagagcaga cccccttgag ggaccttctg ccaggcaccc tggggacatc   1020
 tctgcgcacc ttctagcaag atcctgccct tccaaggagg tgtcagtggc tctgtctccc   1080
 cctctatctc tgtctctcgg tgtctccttc tatctcactg tttctctctc tcgtctgtct   1140
 ctgtctacat cctcaagccc catctcaaat tcactcctat cctgaggccc ccagatgatg   1200
 ccccactcac ctcctgactg tcccagtctc tcctgaagtg ccacctcttc agggaggcct   1260
 gtcgtgacct ccaaacatga gcactcctat cttcttactt tatttcctaa cagcactcac   1320
 cacagcttga ctttgta                                                  1337



      <210> 697
      <211> 4115
      <212> DNA
      <213> Homo sapiens


      <400> 697
 cttcttgggg ggcaggtgct actacattcc aagaatatca gaaaactggg gaactctcaa     60
 catccgatca catatttccc ctcactccag gccttgttta tagtatccct tttgatcaca    120
 ttgttctgca ttcaggacaa agacctccag agctccctaa atctacagaa atccatgagc    180
 aaaaacgcca ctgcaacacc acacgccatt ctaagccaac tgacaagcct acaggcaact    240
 ccaaaactat agaccacaaa agctctacag ataatcatga ggctcctccc acttctgaag    300
 aaaactccag caaccaaggg aaagacccaa tgatccggaa ccagcgctct gttgatcctg    360
 ctgactccac taccacacat aaagaatccg ctggaaaaaa acatataaca ccagcaccca    420
 agagcaaaat aaactgtcgt aagtccacaa caggcaaatc aacggtaaca agaaaatcag    480
 ataaaactgg aagacctttg gaaaagtcca tgagtacttt ggataagaca agtaccagct    540
 cacataagac tacaacttcc ttccacaact caggcaattc acagaccaag caaaaaagca    600
 catcttttcc agaaaaaatc acagcagcct caaaaacaac atacaagacc acaggaaccc    660
 cagaagagtc agaaaaaact gaagattcca gaacaacagt tgcctcagac aagctcctga    720
 caaaaactac aaaaaacata caagagacca tatcagccaa tgagctcaca caatctctag    780
 cagagcctac agaacatgga ggaaggacag ccaatgagaa caacacacca tccccagcag    840
 agcctacaga aaatagagaa aggacagcca atgagaacac cacactatcc ccagcagagc    900
 ctacagaaaa tagagaaagg acagccaatg agaacaccgc accattccca gcagggccta    960
 cagaaaatag agaaatgaca gccaatgaga ataccacact attcccagca gagcctacag   1020
 aacatggaga aaggacagcc aatgagaaca ccacaccatc cccagcagag cctacagaac   1080
 atggagaaag gacagccaat gagaacacta caccatcccc agcagagcct acagaacatg   1140
 gagaaaggac cccatttgcc aatgacaaaa ccacatcatc ctcagcagag tctacagaac   1200
 atggagaaag gaccccactg gccaacgaga acaccacacc atccccagca gagcctacag   1260
 aaaatagaga aaggacagcc aatgagaaca ccacaccatc cccagcaggg cctacagaaa   1320
 acagagaaac gacagccaac gagaagacca cactatcccc agtagagcct acagaaaata   1380
 gagaaacaac agccaatgag aagaccacac catccccagc agagcctaca gaaaatggac   1440
 aaaggacccc atttgccaat gagaaaacca catcatcctc agcagagcct acagaacacg   1500
 gagaaaggac cccactggcc aatgagaaca ccacaccatc cccagcagag cctacagaaa   1560
 atagagaaag gacagccaat gagaagacca caccatcccc agcagagcct acagaaaatg   1620
 gagacaggac tcctttggcc aatgagaaga ccacgccatc tctagcagag cctacagaaa   1680
 atggacaaag gaccccattt gccaatgaga agaccacatc atcctcagca gagcctacag   1740
 aacacgaaga aaggactcca ctggccaatg agaacaccac accatccccg gcagagccta   1800
 cagaaaatag agaaaggaca gccaatgaga acaccacacc atccccagca gggcctacag   1860
 aaaatagaga aatgacagcc aacgagaaga ccacactatt cccagcagag cctacagaaa   1920
 atagagaaag gacagccaat gagaagacca catcatcccc agcagagcct acagaaaatg   1980
 gacaaaggac cccatttgcc aatgagaaaa ccacatcatc ctcagcagag cctacagaac   2040
 acggagaaag gaccccactg gccaatgaga acaccacact atccccagca gggcctacag   2100
 aaaatagaga aaggacagcc aatgagaaga ccacaccatt cccagcagag cctacagaaa   2160
 atagagaaag gacagccaat gagaacacca caccatcccc agcacagcct acagaaaatg   2220
 gagacaggac tccattggcc aatgagaaga ccacaccatc tctagcagag cctacagaaa   2280
 atggaaaaag gaccccattt gccaatgaga agaccacatc atcctcagca gagcctacag   2340
 aacacgcaga aaggactcca ctggccaatg agaacaccac atcatcccca gcagagccta   2400
 cagaaaatag agaaaggaca gccaatgaga agaccacaca attcccagca gagcctacag   2460
 aaaatagaga aagcacagcc aatgagaaga ccacaccatt cccagcagag cctacagaaa   2520
 atagagaatg gacagccaat gagaacacca cactatcccc agcagagcct acagaacatg   2580
 aagaaatgac cccattggcc aatgagaaga ccacactatc cccagcagag cctacagaaa   2640
 atggagaaag gaccccattt accaatgaga agaccacacc atcctcagca gagcctacag   2700
 aacatggaga aaggacccca ctggccaatg agatcaccac accatcccga gcagagccta   2760
 cagaacatgg agaaaggata gccaatgaga aggccacacc atccccagca aagcctacag   2820
 aacatggaga aacgacagtc aatgaggaca ccacaccatc ctcagcagag cctacagaaa   2880
 atggagaaag gaccccactg gccaatgaga acaccacaac atccccaaca gagtctacag   2940
 aacatggaga aaggacagcc aatgagaaga ccacaccatc cccagcagag cctacagaac   3000
 atggagaaag gacaccatca gccaatgaga agaccatacc atctccagca aagcctacag   3060
 aacacgaaga aatgacccca tcggccaatg agaacaccac accatcccca gtaaagccta   3120
 cagaacatgg agaaaagact acattggcca atgagaagat cacactatcc ccagaagggc   3180
 ctacagaaca tggagcaaaa actacgtcgg ccaatgagaa gatcacacca tccctagcaa   3240
 agcctacaga acatggagaa aggaccacat cacccaatga caagatcacc tcatctgcag   3300
 cagagtctac agaacataga gatagggcta catcagccaa tgtgatcaca ccagccccag   3360
 cagagcctat aaaacatgca aaaaggacca cattggccca tgagaagatg acacaagtca   3420
 cagaaaagtc cacagaacac ccagaaaaga ccacgtcaac cacagagaaa accacaagaa   3480
 ccccagaaaa gcctacgcta tactcagaga agaccatatg caccaaaggg aaaaacacac   3540
 cagtcccaga aaagcctaca gaaaacctgg ggaacaccac actgaccact gagaccataa   3600
 aagccccagt aaagtccaca gaaaacccag aaaaaacagc agcagtcaca aagactataa   3660
 aaccttcagt caaggtcaca ggagacaaat ctctcactac tacctcttct catctaaata   3720
 aaactgaagt tactcatcag gtgcccactg gttctttcac cctcattaca tctagaacga   3780
 agctgagttc tatcacatca gaagccacag gaaacgagag ccatccatac ctcaataaag   3840
 atggctcaca gaaaggtatc cacgctggac agatgggaga gaatgattca ttccctgcat   3900
 gggccatagt tattgtggtc ctggtggctg tgattctcct cctggtgttc cttggcctga   3960
 tcttcttggt ctcctatatg atgcggacac gccgcacact aacccagaac acccagtaca   4020
 atgatgcaga ggatgagggt ggccccaatt cctacccggt ctacctgatg gagcagcaga   4080
 atcttggcat gggccagatc ccttccccac ggtga                              4115



      <210> 698
      <211> 309
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(309)
      <223> n = a,t,c or g


      <400> 698
 ggctgttggg cgaccaaggc cttcccggag tcttcgtcct ctatgagctc tcattggggg     60
 catgttcaca gtggctggac tcatcgattc gctcatctac cactcagcac gagccatcca    120
 gaagaaaatt gatctaggga agacaacgta gtcaccctcg gtgcttcctc tgtctcctct    180
 ttctccctgg cctgtggttg tcccccagcc tctgccaccc tccacctcct cggtcagccc    240
 cagccccagg ttgataaatc tattgattga ttgtgatagt nnnnnnnnnn nnnnnnnnnn    300
 nnnnnnnnn                                                            309



      <210> 699
      <211> 2521
      <212> DNA
      <213> Homo sapiens


      <400> 699
 ggcacgagcc gtcccggcgg taatgcgctc ccggccgtga cccccgctgg gggcgggggc     60
 cgggatccat gcgcggagcc cccacccggc ccggcgcctg cggctgacgg cggcgggggt    120
 tggggggcgc gcgtctggcc tcctgcccac cccctggcgt cgacatcacg ggccgtcggg    180
 ggctgcgccc taccccgcgg ccaggctctg gcagggaccc tggaggtgcc gccggcctca    240
 gcccatggcc caaaggtacg atgagctgcc gcactaccca ggcatcgcgg atggccccgc    300
 agccctggct ggcttcccag aggcagtgcc cgcggcacca gggccctatg gccctcaccg    360
 gcctccccag cccctacccc caggcttgga cagcgacggc ctgaagaggg acaaggatga    420
 gatctatgga cacccgctct tccccctctt ggccctgggc tttgagaaat gtgaactggc    480
 tacatgctct ccccgtgatg gggccggagc tgggctgggg acaccccgcg gcggcgacgt    540
 ctgctcctct gattccttca acgaggacaa cactgccttc gccaagcagg tttgctctga    600
 gaggcccttc tcctccaacc cagaactgga caatctgatg atccaggcaa tccaagtgct    660
 gcggttccac ctgctagagc tggagaaggg aaagatgccc atcgacctgg tcatcgagga    720
 tcgggatggc ggctgcaggg aggacttcga ggactaccca gccccctgcc ccagcctccc    780
 agaccagaat aatatatgga ttcgagacca tgaggatagc gggtctgtac atttggggac    840
 cccaggtcca tccagcgggg ggctggcctc ccagagtggg gacaactcca gtgaccaagg    900
 agtcgggctg gacaccagcg tggcctctcc cagttctggt ggagaagatg aggacttgga    960
 ccaggagcca cggcgaaaca agaagagggg gatcttcccc aaggtggcca ccaacatcat   1020
 gcgagcctgg ttgttccagc acctctcaca cccgtacccc tcggaggagc agaagaaaca   1080
 gctggcgcag gacacggggc ttaccatcct gcaagtcaac aactggttca ttaatgcccg   1140
 gagacgcatc gtgcaaccta tgatcgatca atccaaccgc acagggcagg gtgcagcctt   1200
 cagcccagag ggccagccca tcgggggcta taccgagaca gagccacacg tggccttccg   1260
 ggctccagca tcagtgggga tgagtttgaa ctcggaagga gaatggcatt atctatagag   1320
 gctgatgcgg gagagaccca gcctccggct gtgaccccca gcctcacacc tggctctggt   1380
 tcccgcctgg tcctctggct tcaggatccc acctccaaag gcctctccgc tcaacgccta   1440
 cctccctaag gccctgctgg gacatggggg cctgagtgcc cacccaaggg gctctcaagg   1500
 acaccggcaa ggcctccagg ctctgagccc cgcttctgcc ttcacctctg cctgggaccc   1560
 gagctgggct cctgggcctt ggtccccaga agatggcagc tagggcctcg ccgcgaggac   1620
 agagaaggga cagggtggct gggcagtcag ggaaggaggg tcgcccggat ccgacatttt   1680
 ggagagattc tttcaccctc ctgtcccccc cacctccctt ctctaatttc ttcttttttt   1740
 aatgataaag tcttaaaaca cagaaaaaaa aaagacttca gagaattagg tagatgaagc   1800
 actttataca gtatatatct tcagcttaaa tttgttttga gtattttttt tatttttaag   1860
 taggcaaaga tttaaaattt tttattttta gtttgcttca aacatttact aaaaagacgt   1920
 gggcaatatt taccaaaaca aaacagaacc caaaaaattg tacatcttga tcttagcaaa   1980
 tatccttatt gtagagacac ttaataaaga gatggtattt taatatctgc agttctgagg   2040
 tagggtgtaa cttagttcta cattgtgatt taggaatttt taaacctttc ttcttcaggg   2100
 gagaagtgac ccaggcctcg agtttagtgc taaagccact agtgtactta tgctgtcacc   2160
 taaccaccac atgcgacatg gaggcagagg ctaaatatag gggctttctt aagaaagtga   2220
 gaggaaatta gcaagcatta ttagtgtttg actactgcta tcaagtgaat tcaaaggaaa   2280
 caggttttta tgccatattt aagttacaga aaccaggcat gcttagaata gtttctagag   2340
 gttattggag aatagaaagc taagaaaact tggtatacga tttacaatgg aaatataatt   2400
 acacttttta ctctcagaat attgttcaca ttagacttcc tgtttatctt ttatattctt   2460
 gcatttatat aatgcctcat cctttcaaag ttctttcaca tattatatga tcttctttat   2520
 g                                                                   2521



      <210> 700
      <211> 2037
      <212> DNA
      <213> Homo sapiens


      <400> 700
 atggcgccat attgtagcag gacgagccgc agacaaaact cctcagacac cgagttaaag     60
 aaggaatggg tttattcggc cgggggcatc ggcaagactc ctgtgtcagg agccgagctc    120
 ccccaccagc caacagtagt agctgaaaag cgagagcaca ctgatgaaga acactgcggg    180
 cacaaagaaa aggaaaaaac gtggcgttct caggaattga cgtcctccag gcccccagat    240
 gagggtagtg agcaccctga gagccagctg gactcccctc ttggtgtgtt actgcacagc    300
 cacagcctct ggagtggaat gatagctgat gacatcattt taaaagtcac agtactacag    360
 agatgtttgg acactcatca gaggcagacc tgctgtggga aagtcaaggc cttggctgat    420
 gcaaaaataa ttgcagtttt tgccattaca ataattctta ccaagaacta ttcacattgg    480
 accaaagcca attgtaatga tccatgtgat ggagagagcc agaatgctat gaaagtggcc    540
 ttgaccagaa ataggtcatt tgatccttgg ctcattgaca tctccataga ttttcggtgt    600
 acaatgttcg gtctgatgtg caaggtacaa cttttccaga gaagaagagg aggggggcgg    660
 ggaggagcag gaggaggagg aaagaaggag gagaaggaga aggagaagga gaaggagagg    720
 aagaggaaga ggaagaggaa gaggaagaag aagaagaaga agaagaagaa gaagaagaag    780
 aagaagaaga agaagaagaa gaagaagaag aagaagaaga agaagaagaa gaagaagaaa    840
 aggaagaaga agaaactgtc tctacacctt cattctcagg acaagttcat tgtctggcac    900
 caagctcctt gggacgcgga ggttggggtc atggcgcccc gaagcctcct cctgctgctc    960
 tcaggggccc tggccctgac cgatacttgg gcgggctccc actccttgag gtatttcagc   1020
 accgctgtgt cgcggcccgg ccgcggggag ccccgctaca tcgccgtgga gtacgtagac   1080
 gacacgcaat tcctgcggtt cgacagcgac gccgcgattc cgaggatgga gccgcgggag   1140
 ccgtgggtgg agcaagaggg gccgcagtat tgggagtgga ccacagggta cgccaaggcc   1200
 aacgcacaga ctgaccgagt ggccctgagg aacctgctcc gccgctacaa ccagagcgag   1260
 gctgggtctc acaccctcca gggaatgaat ggctgcgaca tggggcccga cggacgcctc   1320
 ctccgcgggt atcaccagca cgcgtacgac ggcaaggatt acatctccct gaacgaggac   1380
 ctgcgctcct ggaccgcggc ggacaccgtg gctcagatca cccagcgctt ctatgaggca   1440
 gaggaatatg cagaggagtt caggacctac ctggagggcg agtgcctgga gttgctccgc   1500
 agatacttgg agaatgggaa ggagacgcta cagcgcgcag atcctccaaa ggcacacgtt   1560
 gcccaccacc ccatctctga ccatgaggcc accctgaggt gctgggccct gggcttctac   1620
 cctgcggaga tcacgctgac ctggcagcgg gatggggagg aacagaccca ggacacagag   1680
 cttgtggaga ccaggcctgc aggggatgga accttccaga agtgggccgc tgtggtggtg   1740
 cctcctggag aggaacagag atacacatgc catgtgcagc acgaggggct gccccagccc   1800
 ctcatcctga gatgggagca gtctccccag cccaccatcc ccatcgtggg catcgttgct   1860
 ggccttgttg tccttggagc tgtggtcact ggagctgtgg tcgctgctgt gatgtggagg   1920
 aagaagagct caggtgattg gattgtggct gcccacagcg agagaggatt ttccccgctc   1980
 agtcactcac atgccaatcc cttccagaaa caccctcgca ggcacaccca gaaataa      2037



      <210> 701
      <211> 407
      <212> DNA
      <213> Homo sapiens


      <400> 701
 gaatgcagat ttccagctat gaaggcgcct gtggtcatct gaatgcagag tttcttggac     60
 atcatgatgt ggtactgcag tgggttgcag atggccacat agcggtcata ggccactgct    120
 gccagaagaa agcagtctgc agtttccaca gtgcaaagaa aataaaactg tactgcacat    180
 tcatagaggg aaatcctttt gccctcagaa aagaagttct ctaacatttt gggggtaata    240
 gcacaggccc gcgagaatcc acaagagcca gatttcccag aaagatgtac attggtgtgt    300
 gaagccgaca gtgtgtaaat atcagtgcca ccaaactaat attccccacc acggtcatca    360
 gatagatggc aaagaacacc acaaacagca gagtcttcag ttcaggg                  407



      <210> 702
      <211> 881
      <212> DNA
      <213> Homo sapiens


      <400> 702
 gcggatgtcc ccggggcaca gcgagcggtt cctggtgacg gcccagagcc ccgggacccc     60
 ctggactgtt gggcctgcgc tgttcttgta acagcccaga atctgctggg ggctgccttc    120
 aatcttctcc tgctggtgct ggtgctaggg accatcttgc tacccgctgt caccatgctg    180
 ggcttcggct tcctctgcca ctctcagttc ctgcgctccc aggcaccccc ttgcaccgcg    240
 cacctgcggg accccggttt cacggcccta ctggtcaccg gattcctgct cctcgtgccg    300
 ctgctcgtgc ttgctctggc cagctaccgc cgcctctgcc tgcgcctccg cctagccgat    360
 tgcctcgtgc cctacagccg agccctttat cggcgtcggc gcgccccgca gccgcggcaa    420
 atccgggcct caccagggtc ccaggccgtt cccacatcag gaaaggtctg ggtctaatga    480
 ccctcgagtc aagaacaacc ctgacgggct gccctcccct cttaattcgg ccccaaggac    540
 ttgaagcccg gcatcttccc gaccctgccc tgccccccac ccctgcctga gcggagtcct    600
 agcatcccct tgggagcagc agcgtcagtg gaccccagtg ctgagaaaag ccccccacat    660
 cccggaaaac ccactttcct ttcacgabcc cacatctcaa tcctgaacat ctaggctgga    720
 acctgcacac kctccccctc agctccgtcg tgaatgggac aacaatctcg tgccctcgtt    780
 ttatggtgca gcttctctag tatttctggg gctggggggc ggggctggag gggaaggagt    840
 gtccacgcat caataaagat ttaacgaact gaacgcgcaa a                        881



      <210> 703
      <211> 413
      <212> DNA
      <213> Homo sapiens


      <400> 703
 atggccaggg gtggcggcca ggctagcatg gaggcactca ccagctgagt tgatgacatg     60
 tctgaccacc tgcagggtgc ccacgcgggt cctctcattg ctggtgtcca gcctgggcag    120
 caggaaggcc agtaggcggt caggcgagct gcaggctaca gggcaacggg tacagattag    180
 gctccatgtc atcttgttca tccctataca cagcgtccac ctactctcca gcacagggga    240
 ggagccagag gagagttgct gtgtgaaggt gagaagctgg ggccacctaa tcgctgggcc    300
 tggctccgat gcccctgtct aaggcagggt tggagcacat gtagccctta tcccacggcg    360
 ccagcaccac ccgagcatgc cgggacttag atcttggccc acccagcaca ccg           413



      <210> 704
      <211> 838
      <212> DNA
      <213> Homo sapiens


      <400> 704
 cggacgcgtg ggaagtcctt tatgtttctg gaaattctgc tgaggtattc tttgtagatt     60
 atggcaataa gtctcatgta gatctacatc ttttgatgga gattccctgt caatttcttg    120
 aacttccttt ccaggctttg gaatttaaga tttgcaaaat gagaccatca gcaaagtctc    180
 ttgtttgtgg caagcactgg agtgacgggg ccagccagtg gttcgcctct ctggtgagcg    240
 gctgcaccct ccttgtgaag gtcttctctg tggtgcacag cgtcctgcac gtggatgtgt    300
 accagtactc aggggtccag gatgccatca acataagaga cgtcctcatc cagcagggct    360
 atgccgagct cacggaggag tcctacgagt ccaagcaaag ccatgaagtt ctcaagggcc    420
 tcttttccaa gtcagtagaa aacatgacag atggctctgt gccctttccc atgaaagacg    480
 acgagaaata tctcatccgg attttgttag agagcttttc taccaataaa ctgggtactc    540
 caaactgtaa ggcagaactt cacgggcctt ttaaccctta tgaactaaag tgccatagtt    600
 tgaccagaat atccaaattc aggtgtgttt ggattgagaa ggagagcatc aactctgtca    660
 ttatcagtga cgcccctgaa gaccttcacc agagaatgct ggttgcagct tccctttcca    720
 tcaatgcgac tggatctacg atgctgctga gagaaacctc tctgatgcct catatccctg    780
 gcctcccggc tctcctcagc atgttattcg caccggtgat agagttaagg attgatca      838



      <210> 705
      <211> 2177
      <212> DNA
      <213> Homo sapiens


      <400> 705
 cggcttcgtg gaagcgggcg aggagtgtta ctgcgtttcc tggccaggag tgccgcgacc     60
 tctgctgctt tgctcacaac tgctcgctgc gcccgggggc ccagtgcgcc cacggggact    120
 gctgcgtgcg ctgcctgctg aagccggctg gagcgctgtg ccgccaggcc atgggtgact    180
 gtgacctccc tgagttttgc acgggcacct cctcccactg tcccccagac gtttacctac    240
 tggacggctc accctgtgcc aggggcagtg gctactgctg ggatggcgca tgtcccacgc    300
 tggagcagca gtgccagcag ctctgggggc ctggctccca cccagctccc gaggcctgtt    360
 tccaggtggt gaactctgcg ggagatgctc atggaaactg cggccaggac agcgagggcc    420
 acttcctgcc ctgtgcaggg agggatgccc tgtgtgggaa gctgcagtgc cagggtggaa    480
 agcccagcct gctcgcaccg cacatggtgc cagtggactc taccgttcac ctagatggcc    540
 aggaagtgac ttgtcgggga gccttggcac tccccagtgc ccagctggac ctgcttggcc    600
 tgggcctggt agagccaggc acccagtgtg gacctagaat ggtgtgccag agcaggcgct    660
 gcaggaagaa tgccttccag gagcttcagc gctgcctgac tgcctgccac agccacgggg    720
 tttgcaatag caaccataac tgccactgtg ctccaggctg ggctccaccc ttctgtgaca    780
 agccaggctt tggtggcagc atggacagtg gccctgtgca ggctgaaaac catgacacct    840
 tcctgctggc catgctcctc agcgtcctgc tgcctctgct cccaggggcc ggcctggcct    900
 ggtgttgcta ccgactccca ggagcccatc tgcagcgatg cagctggggc tgcagaaggg    960
 accctgcgtg cagtggcccc aaagatggcc cacacaggga ccaccccctg ggcggcgttc   1020
 accccatgga gttgggcccc acagccactg gacagccctg gcccctggac cctgagaact   1080
 ctcatgagcc cagcagccac cctgagaagc ctctgccagc agtctcgcct gacccccaag   1140
 cagatcaagt ccagatgcca agatcctgcc tctggtgaga ggtagctcct aaaatgaaca   1200
 gatttaaaga caggtggcca ctgacagcca ctccaggaac ttgaactgca ggggcagagc   1260
 cagtgaatca ccggacctcc agcacctgca ggcagcttgg aagtttcttc cccgagtgga   1320
 gcttcgaccc acccactcca ggaacccaga gccacattag aagttcctga gggctggaga   1380
 acactgctgg gcacactctc cagctcaata aaccatcagt cccagaagca aaggtcacac   1440
 agcccctgac ctccctcacc agtggaggct gggtagtgct ggccatccca aaagggctct   1500
 gtcctgggag tctggtgtgt ctcctacatg caatttccac ggacccagct ctgtggaggg   1560
 catgactgct ggccagaagc tagtggtcct ggggccctat ggttcgactg agtccacact   1620
 cccctggagc ctggctggcc tctgcaagca aacataattt tggggacctt ccttcctgtt   1680
 tcttcccacc ctgtcttctc ccctaggtgg ttcctgagcc cccaccccca atcccagtgc   1740
 tacacctgag gttctggagc tcagaatctg acagcctctc ccccattctg tgtgtgtcgg   1800
 ggggacagag ggaaccattt aagaaaagat accaaagtag aagtcaaaag aaagacatgt   1860
 tggctatagg cgtggtggct catgcctata atcccagcac tttgggaagc cggggtagga   1920
 ggatcaccag aggccaggag gtccacacca gcctgggcaa cacagcaaga caccgcatct   1980
 acagaaaaat tttaaaatta gctgggcgtg gtggtgtgta cctgtaggcc tagctgctca   2040
 ggaggctgaa gcaggaggat cacttgagcc tgagttcaac actgcagtga gctatggtgg   2100
 caccactgca ctccagcctg ggtgacagag caagacccct gtctctaaaa taaattttaa   2160
 aaagacatat tacactt                                                  2177



      <210> 706
      <211> 2925
      <212> DNA
      <213> Homo sapiens


      <400> 706
 agtggccctt atgctgcccc ctcccacccc gctcgcatct gtagcatctg gggactcctg     60
 ggcttcgccg cccgctgcct gacatggtgc tgcccgcctg gcccactccc caaacgcctg    120
 ctccccctag tgtccagcag cctcctggcc actgtgctcc cagcccgggg caatctcgtc    180
 ctgcggagac ggctcattta cattgggcca cgcttcatga tcgggccggg gtccgggctg    240
 gtgtggcagc tgctcgtggg gcaggcagct ggggccgtga ggccaccgtc agaggctacg    300
 ccaagcctgt gtgctccctc ctgcctcagg agcaggcccc cagcacccag ctgcccggct    360
 gccatgcaca aacattacaa agtccacttc gccaaggatg cccagagccc caacgggcac    420
 tacttctggg acccagagtt ggggcaccga aaaggatgct gtcatcagtg gcgccaggac    480
 tcagcggccc tccgagccca tgggccctgt cggccttccc cccaatcaca ctggcagctg    540
 gcctaccaca gccaccaagt gggtggcagt ggctggcgcc ggggcctcct gccctccgtc    600
 ctgcagcagc agcggcagcc ccagtcccag ccctcacctc ccagccccct gcggcagcgg    660
 ctctgcccca ttcacgaagc ccagaagggg ctgcctgcaa cctccactgt ccccaaggaa    720
 cctgccagcg cccctcaggc gcccacctta cccaccacgg caccagccat ggccaggagt    780
 ggcccagctc taccctccgc ggctggcgtc ctcctgaagc ccagcgagcc cactgatgcc    840
 cggcccctgc ccgccccagc ggcctgtggc tccttcactg cctacagctc cgacatcctg    900
 acagaggatg acgtctactg cagctgcctg gccaagacac tctgccacgt gccggtccct    960
 gtgaccgtgg gtttctatgc ccctttcggc tgccgcctgc acatgatgct ggacaagatc   1020
 acggcgctga tgcagcagga ggccgcgcag cgcgagagcg aggagctgca gcacgtgcag   1080
 tggcggccgc gtgccgtgag cggctggggc gtcccgcagc tactgtggta cctggtgttc   1140
 ctgcagccca tcatcaccga ggtgcacctg cggcgcagga acgtgcagtt ccttttcatc   1200
 cgctttagcg cctggcagta cgcgggcacc gacaagctgt gggccggcct ggtgaccacg   1260
 ttgtgcgagg gcatccgccg ccactatggc gcactgccct tcagcgtgta ctcggtgctg   1320
 ggcaacaagc cggccaccag gcaggactgc tgccagagcg agtggcattg tcggcgccgc   1380
 gtgtgcctgg ggctgctggc gctgctggcg gcgctgggcc tgggtgtggg gctgctctac   1440
 ttgtcactgg gcggccacgc gctgggccac ggcagcccga gcggcagcct gctcaaggtg   1500
 tttggcggcg cggccaccac actgtcgggc tcggggctgc tcatggccgt gtactcggtg   1560
 ggcaagcacc tgttcgtaag ccagcgcaag aagatcgagc ggctggtgtc gcgtgaaaag   1620
 ttcggcagcc agctgggttt catgtgcgag gtgaagaagg aggtggagct gctcaccgac   1680
 ttcctgtgct tcctggagat ctaccagcgg cgcaggctgc gcgtggtgct ggaggtcacc   1740
 gggctggaca cgtgctaccc ggagcgcgtg gtgggcgtgc tcaacgccat caacacgctg   1800
 ctgtccgaca gccacgcgcc cttcatcttc atcctggtcg tggaccccag catcctggcc   1860
 gcgtgcctag agagcgcggg caacatgaag ggcacggccg ataacggcta cctcttcctc   1920
 aaccgcactg tcacgctgcc cttctctgtg cccattatgg gccgccgcac caagctgcag   1980
 ttcctgcacg atgcggtgca gagccgcgac gacctgttgt accgcgagat gacgcgcaag   2040
 ccgtggctgc cgggggacgc cgggggcgag agcgcgcagc tgctggcggt gcaggcgcag   2100
 gcggggacgg agcgcgggca gggccgcatc gacgacgagg cggcgcggcg aatccaggag   2160
 gcgctcttct gccttcacga cgagcgcgac tgcctctacg agtacgtgcc cgacaacgtg   2220
 gtgtccatgc ggcgcatcgt caacaccgtg cccatcaccg tgcgcctgct gcagcagcag   2280
 cagcagcagg gggactttgg gggccccacg ccgcgccagg cggtggcgtg ggtggtgctc   2340
 gccaaccagt ggccgtgccg cctgagctgg gcgctgcagt gcctggagga ccggcagcag   2400
 accgggggcg cgcccgaggg ccgcgcgcgc ctctgggacg ttttccgcga caacagccgc   2460
 gagctgcaca ccatgaccaa ggcgttgcag aacgtgctcg acctggacgg cgaccccgag   2520
 ctcttcgagc gcttcctggg cgccgacttc cccttcaccg tggccgaggc gcagagcctg   2580
 ctgcgctgca cggtcaacct ggaccactcc atccgccggc gcatgggtct catccgagcc   2640
 gtcagcgcgc tcaagccgcc cagcccgccc aagtccccta cccgcgatac cccccacgct   2700
 gcccaccggg ccaacagcgc ctccagggcg cccccgtcgg gccgtgcctc agggcaagcc   2760
 ggcgaaggcc accacactgg ggacttggcc cacaggggca agctatggcc ggtggcctgt   2820
 gcgctcttcc gtccagggca atccagccca gggtacctgc cttacgagtc actccagggc   2880
 cactggttag tcactgacac tgaagccact gcatcagccc cctga                   2925



      <210> 707
      <211> 857
      <212> DNA
      <213> Homo sapiens


      <400> 707
 tttcgtctcc tagaggggca ggctcggcga caaggggcgg tggtgccccg tcccagcgag     60
 ggacgcccgg ggctgggggt gccggtcgag cccggggcaa cagcttcacc aagtttggca    120
 accgcaacgt cttcatgaag gacaacagct cttcttccag cacagactcc cgctcccgct    180
 cctcctccag gtccccgacg cgccacttcc gcagaagtga ctcccactca gactccgaca    240
 gctcctactc agggaatgag tgtcaccctg tgggccgcag gaacccgccc cctaagggcc    300
 ggggcggtcg aggggcccat atggatcggg gccgaggcag ggcgcagcgt gggaagaggc    360
 acgatctggc gcccaccaag cgcagtcgaa agaagatggc ggcgctggag tgtgaggacc    420
 cggagcgaga gctgaagaag cagaagcggg cagcccgctt ccagcacgga cactcccgcc    480
 gcctgcgcct cgagcccctg gtgctgcaga tgagcagcct ggagagcagt ggggctgacc    540
 ctgactggca ggagctgcag atcgtgggca cctgccctga catcaccaag cactacctgc    600
 gcctcacctg tgcccccgac ccgtccaccg tgcgccctgt ggcagttttg aaaaagtcgc    660
 tgtgcatggt caagtgccac tggaaagaga agcaggacta cgcgtttgcc tgcgagcaga    720
 tgaagtcgat ccggcaggat ctgacggtgc agggcatccg caccgagttc acggtggagg    780
 tgtacgagac ccatgcccgg atcgccttgg agaagggtga ccataaagag tataaccagt    840
 gccagacgca ctgtatt                                                   857



      <210> 708
      <211> 1421
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(1421)
      <223> n = a,t,c or g


      <400> 708
 ggcagcgagg atgtggtaca gcgcatggac ctggagggag gctgggaact gctcaggacc     60
 tcggcggggc atgaggaggg ggccaccagg ttggccagcg gccccctttc ccagggccat    120
 ggctgagcac gcagggcccc gactccccct ggtgctgaag acgctggcat gcacacacag    180
 cagtgcgtat gagaaccaga gggtgaccac caccgccttc ctggccgagc tgctgaacag    240
 caacgtggcc aacgacctca tgctcttgga ctcgctgctg gagagcctgg cggctcgcca    300
 ganaggacac atgcgccagc gtgcggaggc tggtgctccg cggcctggcc aacctggcct    360
 ccggctgccc tgacaaggtg cgaacccacg gcccccagct cctcacagcc atgattggcg    420
 ggctggacga cggggacaac cctcacagcc cagtggccct ggaggccatg ctgggccttg    480
 cgaggctggt gcacctggtg gagtcctggg acctgcgctc agggctgctg cacgtggcca    540
 tccgcatccg gcctttcttc gacagtgaga agatggagtt ccggacggca tctatccgcc    600
 tctttgggca ccttaacaag gtctgccacg gagactgtga ggacgtcttc ctggaccagg    660
 tggtgggcgg gctggcgccc ctgctgctgc acctgcagga ccctcaggcc accgtggcca    720
 gcgcctgcag gtttgccctg cgcatgtgtg gccccaatct ggcatgtgag gagctctcag    780
 ctgctttcca gaaacacctg caggagggcc gagccctgta cttcggggag ttcctcaaca    840
 ccacctgcaa gcacctgatg caccatttcc cagacctgct gggccgtctc ctgaccacct    900
 gcctgttcta cttcaagagc agctgggaga acgtccgagc tgctgcaccc ctgttcaccg    960
 gtaagcacca ccccctgccc cacccccacg ccgcccggca gccccgcctg atgcccccac   1020
 ttcacagggt tcctggtgct gcactcggag cccaggcagc agccgcaggt ggacctggac   1080
 cagctcattg cgggtgagca cccctccacg gggcccctcc gctgggccct gctgaccctg   1140
 taggcacccg cagggactaa gtgattttcc tggatttcag gactttttcc ctgtcactgg   1200
 tgacctcatc gtctctagta attcacggaa acttcttaac tgttccaaga gagcttaaaa   1260
 aacactaaaa aaggaaaaac gatctttccg ttggctcctg agcctcccag cagaggctgt   1320
 caggagagcg tggcccacgc gcaggcatgg gcatgccgag gtcacagccc gcaggcagcc   1380
 cccctcctct acccccagcg ctccagatcc tgctgaagga g                       1421



      <210> 709
      <211> 1373
      <212> DNA
      <213> Homo sapiens


      <400> 709
 accacattcg aggactcgtc cgcgcggtgc aattcctgct cacagctgcc cagctgaaag     60
 ccaaggggga gctgagcttt gaacaggacc agctggtggc tgggggccag ctgggcgagc    120
 tgcacaacgg gacacagtat cgtgaggtcc gccagttctg ctcgggctct ggccaccacc    180
 ttgtgcgctt ctacttcctc actcgtgttt actccgagta ccttgaggat gttctggaag    240
 agctgacata tggacctgcc ccggacctgg tgatcatcaa ctcctgcctc tgggatctct    300
 ccagatatgg tcgctgctca atggagagct accgggagaa cctggagcgg gtgtttgtgc    360
 gcatggacca agtattgcca gactcctgcc tgctggtgtg gaacatggcg atgcccctcg    420
 gggaacgtat cactgggggt ttcctcctgc cagagctcca gcccctggca ggctccctgc    480
 ggcgggatgt ggttgaaggg aacttctaca gtgctacgct ggccggggac cactgctttg    540
 atgtcctaga cctccacttt cacttccggc atgcagtaca gcaccgtcat cgggatggtg    600
 tccactggga ccagcatgca caccgccacc tctcacacct gcttctgacc catgtggctg    660
 acgcctgggg cgtggagctg cccaagcgtg gctatccccc tgacccgtgg attgaggact    720
 gggcagagat gaatcatcca ttccagggaa gccataggca gaccccagac ttcggggagc    780
 acctggcctt gctcccaccc ccaccttctt ctttgcctcc tcccatgcct tttccctacc    840
 cacttcctca gccctcgcca cctcccctct tcccacccct gccccaggat accccttttt    900
 tcccaggcca gcccttccca ccccatgaat tcttcaacta taatccagtg gaggacttct    960
 cgatgccacc ccacttagga tgtggccctg gagtgaactt tgtgcctggc cctctgccac   1020
 ctccaatccc tggccctaat ccccatggtc agcactgggg cccagtggtc caccggggga   1080
 tgccacgcta tgttcctaac agcccctacc atgtgcggag aatggggggg ccctgcaggc   1140
 agcggctcag acactcagag agactgatcc acacatacaa actggacaga cggcctcctg   1200
 cccattcggg gacatggcct gggtagactg gatcttgggc tgggactgga tgtgccaatg   1260
 gcccttcagg gcctgcctgg cacctcaggt actgggctag ggtgtctgct atgcctggta   1320
 ttgttcttgt ccattgctgt caccaataaa ggcatggaag aacaaaaaaa aaa          1373



      <210> 710
      <211> 2767
      <212> DNA
      <213> Homo sapiens


      <400> 710
 atggatgttg gtttttctcg tactactgtt cagacactgt caagaagcca ctgcaaaaac     60
 atcaaacaaa aaatttctca atgggaagga agggctaatg gtatatctaa tccagaaaag    120
 tggtgtccaa aggactttgg agtgagatat aactgtcacc aagagatccg tcttaagaaa    180
 aatcctatag ctgagagaaa gagcaaaaac ttggatgtaa ccagccgtga aaatgtgggt    240
 ctagatataa atgaaaatac caaaagccat gatcaaagtg agaatgaaaa taagaaacat    300
 gaatatgacg atacacactt ctttaaaaat gaatcagaat ccaactgggt atgttctcgg    360
 gtcaaagaaa ttgaaagctg taaagaagat gtcttagatc cagagacttc attacctcca    420
 ggaaacttct atacctcaca aatactgtgg aagaaaatag aagcacttcc cccagataaa    480
 ctcttaaatt tggctttaga acattgtgac tcttcagaaa aagaactgaa cttcagagtt    540
 ctggatagtt catacggaat aaccaagagc ttagaaaata tttactctga acctgagggg    600
 caagaatgtg gaccttccat aaatcctttg ccaaaacctc gtaggacatt cagatattta    660
 tccgaatctg gtgttacgcc gtataaagaa agaaactgtg acaaaaaata ctgtgaaaat    720
 aactcttgtg cacaatcttc tttggcctct tctcaggaac ctgaaccaaa gaaatatggt    780
 ggaaaaatca gaggaagatc taaaaggaaa tcctttgaat ttgaggatat tcagcacttt    840
 cgaaatcgga actcacagac gattcgtgaa gaacttggaa gaaattctgg gtcagcactt    900
 tattacacac agtctgagga caatatctat gaagatatca tatatcccac caaagaaaat    960
 ccatatgaag atattccagt gcagccttta cctatgtgga gatccccttc agcatggaag   1020
 ctaccacccg ctaaaagtgc ttttaaagca cccaagctcc ctccaaaacc tcagttcctt   1080
 caccggaaga ctatggaagt aaagaactca caggcttatt tgcggtcaaa gcttacaaaa   1140
 gatacaactt tgccggtcac tttaacggaa tggaagcttt tccgagctgg tgaagttgca   1200
 aacacgaaaa ggaaaaatct tccaaggctt gtattgaaaa tagatgacat atttgaatct   1260
 aaaagaggga agaagaaggt aaagttacat tcttacactg gaaaggaatt acctccgaca   1320
 aaaggtgaaa ccagtgggaa cgaaagtgat gccgagtatc tgccaaagaa tcgccataaa   1380
 cgcttagcac aactgcaacc gtcttccaag aggaatcctc actaccagac cttggagcgg   1440
 gatcttattg aattacagga gcaagcagct gtttgaacat ttttgtggtg gtgtctctac   1500
 aaggaagaaa ccatcaggaa taagctatat tccccaggtc atacaacaat tccctggcaa   1560
 ggatgatcat ggctataagc agtccaaaga catggaagag agacttaaag ttattccaaa   1620
 attttgtttt cctgattcaa aggactggat gccaacctca gaactcaaga gtgaaacatt   1680
 ctcctttgtc ttgactggtg aagatggaag ccggtggttt ggttactgta agaagctctt   1740
 gccagtaggc aaaggaaagc gactccctga ggtatactgc atggttagtc gcctaggctg   1800
 cttcaatctt ttttcaaaga ttctggatga agtagagaag agaagagaaa tgtctccagc   1860
 ccttgtttac ccattcatgc gaagtgtcat ggaagctcct ttcccagctc ctggacgcac   1920
 catcacagtt aagagttacc tccctggggc tggagatgag tccattgaac tctgccgacc   1980
 actagattcc cgattggaac atgttgattt taaatgtctc tttaagtgcc tgagtgtgtg   2040
 tcatctcatc cgggtctgtg cctctctcct tttggagcgt agggtaatct ttgttgccaa   2100
 cagcctaagc accctgtcaa aatgtggcca tgctgtggta gctacactgt atccgttcac   2160
 ctggcagcat acctatatcc cagtcctgcc agcatctatg attgacatcg tgtgctcacc   2220
 tacaccattc cttattggaa tcctgtcttg ctccttacca cagctccagg acctacccat   2280
 tgaagaggtg ctgatagttg atctctgtgc agacaagttc ttacaggagg tatctgatga   2340
 ggatgaaatt ctaccaccaa aacttcaagc tgccctgatg cagattttgg aagaacgaaa   2400
 tgaaatcttg actcaggagc agaatttttc acaagcagat gtgacactca actctctggt   2460
 gtccgaagca tttgtcaggt tttttgtgga gttggtagga cattattctt tgaacatgac   2520
 tgtcactgag cgtggggagc gtgttttcca aagggaacca ttccgtaagt cccacacctc   2580
 ccgaagtgta cgccacttcc tggatctctt catggaaact cagatgtttg caggattcat   2640
 ccaggaccga gagcttcgga aaagtggagt taaaggtttg tttgagatcc gggccatcca   2700
 gtatttggaa acaattcctg agtcggagcc cagtgggatg aatagaattt tgcggagtct   2760
 tggttag                                                             2767



      <210> 711
      <211> 945
      <212> DNA
      <213> Homo sapiens


      <400> 711
 ttgcgtgtcc ccaggagctg ggagcgggtg accggcggcg gggaagcggc ctgggttggc     60
 cctcagattg cggggtctgg gggcatctcg ccgggcaaac ccttggcccg cctacaagga    120
 cttcccccgg ccagagcaat ggccgctgag aacagcaagc agttttggaa gaggagcgct    180
 aagctgccgg ggagcattca gcctgtatat ggagcacagc atcctcctct tgacccacgg    240
 ctcaccaaaa atttcattaa agaacgatca aaagtcaaca cagttcctct gaagaataag    300
 aaggcctcca gttttcatga gtttgcacgg aataccagtg atgcttggga cattggcgat    360
 gatgaggaag aggacttttc ctcaccttct ttccaaactc tgaactcaaa agttgctttg    420
 gcaactgcag cccaagttct agaaaaccac agcatgctga gagtaaaacc agaacggtcc    480
 cagtcaacga catcggacgt ccctgccaac tacaaggtca taaagcccag cattgatgcc    540
 cagctgtgca gaaactctag tgatacatgc ctgaggaacc cactccacaa acagcaatca    600
 ctccctctcc ggcccatcat ccccctcgtt gcccggatct cggatcagaa cgcttctggg    660
 gcccccccaa tgactgtccg ggagaaaacc cgcctagaaa aattccgtca acttctctcc    720
 agccagaaca ctgacttaga tgaactgagg aagtgtagct ggccaggggt tcccagggag    780
 gttcgaccta taacctggag actcctgtcg ggctatctcc cagcaaacac tgagaggagg    840
 aagttgaccc tgcagcggaa gcgggaggaa tattttggct tcattgaaca gtattatgac    900
 tctcgaaacg aggaacatca ccaggatacc tacagacagt gtatt                    945



      <210> 712
      <211> 737
      <212> DNA
      <213> Homo sapiens


      <400> 712
 caattcctgg gtcgagcagc tccgagggaa tgtccttctc aatggcctct cattagaggc     60
 agacatcact gccaacttag atagccccag ggtgacagtg gcccagctgg actgggacgt    120
 agcgacggtc catcagctct ctgccttcca gccagatgtt gtcattacag cagacgtgct    180
 gtattgccca gaagccatcg tgtcgctggt cgggatcctg cggaggctgg ctgcctgccg    240
 ggagcaccag caggctcctg aggtctacgt ggcctttacc gtccacaacc cagagacgtg    300
 ccagctgttc accaccgagc taggccaggg tgggatcata tggggaagcg gaagttcatt    360
 catgaccaga aactgtttcc ctatgggaga gcacttggag atgggcaatg ctgaatctca    420
 ccctgtagga ctcacacacg actccaacgg gattgtgaga atcaagtcac tctcatggga    480
 agaattttta tatgggaaag cggataaaac tttcattgga ctggaatgtt tggagaatgt    540
 taatttccaa atcaggaacc acaaactgcc ctctaataag acatcggcta tctaagcgtg    600
 tgggtgcccc ctttctgcca gcagttctgg ttcttaagaa aatcaccata aatcagacat    660
 gaaaattctg gctccaaaaa cagcattttc tttgtgcaaa taaaaacgtg tgtatcaagt    720
 aaaaaaaaaa aaaaaaa                                                   737



      <210> 713
      <211> 1683
      <212> DNA
      <213> Homo sapiens


      <400> 713
 tttcgtgcgg ggcgccaagg ggcgcgccag gagctgctcg ggcgctggga gggagaccag     60
 ggcgcagttc cgggcgcgtc tgagcggttc tcgaggcgtt ctcgcctcgg tctctggcga    120
 gtgcacggat caaaagcagc atggatctgc ctgtggatga atggaaatca tatctgcttc    180
 aaaagtgggc ttcactcccg acgtctgttc aggtcacaat ttctacagca gagaccttga    240
 gggatatctt tcttcactcc tcttcacttc ttcaacctga ggatgagctg tttctaaaaa    300
 gactttctaa aggttacttg gtgggaaagg actcggacgc tcctcttttc tacagagaag    360
 aaggaaacaa aaaatttcag gagaaagatt acacatggag ctgcagcgct gaactctaag    420
 ggagagtcac attcaaggcc taacactgag gacatgtcac tgtgtcatgc taaccgctcg    480
 gcagccctct tccacctggg tcagaatgag acgtgtctta aagacattaa cagagcacag    540
 acacatgggt atgcagaaag gttgcaaccc aagattatgt tacgtaaagc agaatgtctg    600
 gtggccctgg ggagactgca ggaggcaagc cagaccatca gtgatcttga aaggaacttc    660
 acagccacac cagccctagc agatgtcctc cctcagactc tgcagagaaa cctccatcgt    720
 ctgaaaatga agatgcaaga aaaggacagt ctcacagaaa gcttcccagc agctctggcc    780
 aaaacccttg aggatgcagc gctgagggag gagaatgaac aactttccaa tgcctcatca    840
 tccatcggct tatgcgtaga tcctttaaaa ggtcgctgtc tcgttgccac aaaagatatt    900
 ctcccaggag agctcctggt gcaggaggat gcttttgtga gtgttctcaa cccaggagaa    960
 ctgccaccac cgcatcacgg cctagacagc aaatgggaca ccagagtcac caatggggac   1020
 ctctattgtc accgatgttt gaagcacact ttggccacag ttccgtgtga cggatgcagt   1080
 tatgccaagt attgcagcca ggagtgtttg cagcaggcct gggagctcta ccacaggaca   1140
 gaatgtcctc tgggagggct gcttctcaca ctgggtgtct tttgccacat tgcccagagg   1200
 ttgactcttt tggtgggatt tgaggatgtt cgcaaaatca taacgaagct ttgtgataag   1260
 attagtaaca aggacatctg tttacgtgaa agcaacaatc aggtcaagac acttaattat   1320
 ggcctagggg agagtgagaa aaatggcaac atcgttgaga ccccaattcc tggatgcgat   1380
 attaatggga agtatgaaaa taattataat gctgtcttca accttttgcc ccacactgaa   1440
 aaccatagcc cagagcacaa attcctctgt gctctctgtg tttctgcact gtgcagacag   1500
 ctagaagcag ccagtttaca ggcctcccaa agtactggga ttacaggcgt gagccaccgc   1560
 gcccggccaa aatgaacaaa attttaaagt aaactatggg cctgaaaaga ccaaaaaaga   1620
 aaaaaataat aaatgttaca attagagtaa aacttttttt aaatttttat ttatttttct   1680
 tca                                                                 1683



      <210> 714
      <211> 2291
      <212> DNA
      <213> Homo sapiens


      <400> 714
 atgctggtct tgaactcctg ggctcaagtg atccactggc ctcagcctcc caaagtgctg     60
 ggattacagc ctttggaaaa aacccagtac ggcttcctag gaacagatcg tgtagaagag    120
 aaaacttcag tgataaccat cagagttagt gtgacccaca gacacaacag ctacatggaa    180
 gcagaaaacc ttacagaatt atcaaaattt ctcctcctgg gactctcaga tgatcctgaa    240
 ctgcagcccg tcctctttgg gctgttcctg tccatgtacc tggtcacggt gctggggaac    300
 ctgctcatca ttctggccgt cagctctgac tcccacctcc acacccccat gtacttcttc    360
 ctctccaacc tgtcctttgt tgacatctgt ttcatctcca ccacagtccc caagatgcta    420
 gtgagcatcc aggcacggag caaagacatc tcctacatgg ggtgcctcac tcaggtgtat    480
 tttttaatga tgtttgctgg aatggatact ttcctactgg ccgtgatggc ctatgaccgg    540
 tttgtggcca tctgccaccc actgcactac acggtcatca tgaacccctg cctctgtggc    600
 ctcctggttc tggcatcttg gttcatcatt ttctggttct ccctggttca tattctactg    660
 atgaagaggt tgaccttctc cacaggcact gagattccgc atttcttctg tgaaccggct    720
 caggtcctca aggtggcctg ctctaacacc ctcctcaata acattgtctt gtatgtggcc    780
 acggcactgc tgggtgtgtt tcctgtagct gggatcctct tctcctactc tcagattgtc    840
 tcctccttaa tgggaatgtc ctccaccaag ggcaagtaca aagccttttc cacctgtgga    900
 tctcacctct gtgtggtctc cttgttctat ggaacaggac ttggggtcta tctgagttct    960
 gctgtgaccc attcttccca gagcagctcc accgcctcag tgatgtacgc catggtcacc   1020
 cccatgctga accccttcat ctacagcctg aggaacaagg atgtgaaggg ggccctggaa   1080
 agactcctca gcagggccga ctcttgtctc ttacggtgtc cgagctacac agagccacag   1140
 aatctcacag gtgtctcaga attcctcctc ctgggactct cagaggatcc agaactgcag   1200
 ccggtcctcg ctgggctgtt cctgtccatg tacctggtca cggtgctggg gaacctgctc   1260
 atcatcctgg ctgtcagctc tgactcccac ctccacaccc ccatgtactt cttcctctcc   1320
 aacctgtcct tggctgacat cggtttcacc tccaccacgg tccccaagat gattgtggac   1380
 atgcaaactc acagcagagt catctcctat gaaggctgcc tgactcagat gtcttttttt   1440
 gtcctttttg catgtatgga tgacatgctc ctgagtgtga tggcctatga ccggtttgtg   1500
 gccatctgtc accccctgca ctaccgaatc atcatgaacc cacgcctctg tggcttctta   1560
 atcttgttgt ctttttttat tagtcttttg gactcccagt tgcacaattt gattatgtta   1620
 cagctcacct gcttcaagga tgtggacatt tctaatttct tctgtgaccc ttctcaactc   1680
 ctccacctta ggtgttccga caccttcatc aatgaaatgg tcatatattt catgggtgcc   1740
 atatttggct gtctccctat ctcagggatc cttttctctt actataaaat tgtttccccc   1800
 attctgagag ttccaacatc agatgggaag tataaagcct tctccacctg tggctctcac   1860
 ctggcagttg tttgcttatt ttatggaaca gggcttgtag ggtacctcag ttcagctgtg   1920
 ttaccatccc ccaggaagag tatggtggct tcagtgatgt acactgtggt cacccccatg   1980
 ctgaacccct tcatctacag cctgaggaac aaggacattc aaagtgccct gtgcaggctg   2040
 catggcagaa tcatcaaatc tcatcatctc catccttttt gttatatggg atagaaatgg   2100
 cagcaaaatt taacacctag gcctgcaaat tctgcctcct tggtcacatt attttggttg   2160
 cttgatggct ttcattcctc tctgggtttc gtatgtgaat attgcttgct ttgttttgtc   2220
 tttaattgca atgggtgagt attctggtat cctttgttca tcatacacat catgaatgat   2280
 tccaatataa a                                                        2291



      <210> 715
      <211> 1120
      <212> DNA
      <213> Homo sapiens


      <400> 715
 atggatgaac tctccgagtt gagagaattc tatgatccag atacagtgga gctgatgaac     60
 tggattaaca attacactct aggtaagggt agcacagtac acaaggccca gagtaagtgt    120
 ttagatctct taacagtggg gttaattcag actctaaaat ctttcagctc taacactcca    180
 agaaaggctg tgtttgcggg aagcatgcag ttgctggccg gagtcaagct gtgcacggga    240
 aggaccctaa ccaaccaccc gcactatgaa gacagcagcc tgagagagcg gaccagagcg    300
 gtccctacca catcatgtgg gacttcaaga tgtgatttgg gtggggacac agccaaacca    360
 tatcagaggg gaaatcagaa cgtaagtgca cagggctcgc atctcctggt ccaggacctc    420
 tgcctgccca tatccactaa ggacgtgcca ttagaccaca ggtcctcccc aggtcgggac    480
 ctctgcctgc ccatatccac taaggacccc cagaatctgg gacgctcagt ttgcatccat    540
 ccactgaggg tgtgtggcac tggtatgaac gtgaaggggg cctcctgtgg cgttgcccac    600
 ggtgtgctgc aagtggctct cacccctagg atggacgaga gggagaggag cagtggggtc    660
 tctcaattag ctgagatgcg gagtagcagt caagtagcat ttgccacatt gcatttttat    720
 gtctttttga aggtttatca gatatatgcc aagagggcac cagaggaagt gcatgccctc    780
 ctaaggtcct tcggcactga ctacgtaatc ctggaagaca gcatctgcta cgagcggagg    840
 caccgccggg gctgccgact ccgggacctg ctggacattg ccaacggcca cgtgagcatg    900
 ctgcctctcc ctgtgtgggg gtctcctgga ggggcgggac tctgatttga atcctaagaa    960
 tgtgaatctt tttatcctta atgtctagtt gaattacgct acgaatcaag tatttgcttt   1020
 ttctcttgct tcctacagaa gccctctctt ggcactttag tgactgccac tggggctggg   1080
 caagggagag gtgagagggg agccctgggt ccccaaggtc                         1120



      <210> 716
      <211> 556
      <212> DNA
      <213> Homo sapiens


      <400> 716
 tttcgtgggc cggttgctaa gacttggcga agcgctgcgc ttgcgcccgg atccctcagg     60
 cggctgcagg cttcagcctg cgctggttgg tgaaacagag atgtcagaaa aggagaacaa    120
 cttcccgcca ctgcccaagt tcatccctgt gaagccctgc ttctaccaga acttctccga    180
 cgagatccca gtggagcacc aggtcctggt gaagaggatc taccggctgt ggatgtttta    240
 ctgcgccacc ctcggcgtca acctcattgc ctgcctggcc tggtggatcg gcggaggctc    300
 ggggaccaac ttcggcctgg ccttcgtgtg gctgctcctg ttcacgcctt gcggctacgt    360
 gtgctggttc cggcctgtct acaaggcctt ccgagccgac agctccttta atttcatggc    420
 gtttttcttc atctttcgga gcccagtttg tcctgaccgt catccaggcg attggcttct    480
 ccggctgggg cgcgtgcggc tggctgtcgg caattggatt cttccagtac agcccgggcg    540
 ctgccgtggt catgct                                                    556



      <210> 717
      <211> 2017
      <212> DNA
      <213> Homo sapiens


      <400> 717
 tttcgtgcgg gagatcagag gtcccgccgt cccgcgcctg acctcggctg aggacaggca     60
 ccgccatggg ccacacgcac acagcccgga gttgcagcgg accggcagag attacagcct    120
 ggactacctg cccttccgcc tatgggtggg catctgggtg gctacctttt gcctggtgct    180
 ggtggccaca gaggccagtg tgctggtgcg ctacttcacc cgcttcactg aggaaggttt    240
 ctgtgccctc atcagcctca tcttcatcta cgatgctgtg ggcaaaatgc tgaacttgac    300
 ccatacctat cctatccaga agcctgggtc ctctgcctac gggtgcctct gccaataccc    360
 aggcccagga ggaaatgagt ctcaatggat aaggacaagg ccaaaagaca gagacgacat    420
 cgtaagcatg gacttaggcc tgatcaatgc atccttgctg ccgccacctg agtgcacccg    480
 gcagggaggc caccctcgtg gccctggctg tcatacagtc ccagacattg ccttcttctc    540
 ccttctcctc ttccttactt ctttcttctt tgctatggcc ctcaagtgtg taaagaccag    600
 ccgcttcttc ccctctgtgg tgcgcaaagg gctcagcgac ttctcctcag tcctggccat    660
 cctgctcggc tgtggccttg atgctttcct gggcctagcc acaccaaagc tcatggtacc    720
 cagagagttc aagcccacac tccctgggcg tggctggctg gtgtcacctt ttggagccaa    780
 cccctggtgg tggagtgtgg cagctgccct gcctgccctg ctgctgtcta tcctcatctt    840
 catggaccaa cagatcacag cagtcatcct caaccgcatg gaatacagac tgcagaaggg    900
 agctggcttc cacctggacc tcttctgtgt ggctgtgctg atgctactca catcagcgct    960
 tggactgcct tggtatgtct cagccactgt catctccctg gctcacatgg acagtcttcg   1020
 gagagagagc agagcctgtg cccccgggga gcgccccaac ttcctgggta tcagggaaca   1080
 gaggctgaca ggcctggtgg tgttcatcct tacaggagcc tccatcttcc tggcacctgt   1140
 gctcaagttc attccaatgc ctgtgctcta tggcatcttc ctgtatatgg gggtggcagc   1200
 gctcagcagc attcagttca ctaatagggt gaagctgttg cttgatgcca gcaaaacacc   1260
 agccagacct gctactcttg cggcatgtgc ctctgaccag ggtccacctc ttcacagcca   1320
 tcagctttgc cctgtctggg gctgctttgg gataatcaag tctacccctg cagccatcat   1380
 cttccccctc atgttgctgg gccttgtggg ggtccgaaag gccctggaga gggttttttc   1440
 accacaggaa ctcctctggc tggatgagct gatgccagag gaggagagaa gcatccctga   1500
 gaaggggctg gagccagaac actcattcag tggaagtgac agtgaagatt cagagctgat   1560
 gtatcagcca aaggctccag aaatcaacat ttctgtgaat tagctggagt aggagtctgg   1620
 gagtggagac cccaggaaac agcatgaggt gcttactcag gaagtcagga catttttggc   1680
 ctttggctta acttccagat gctcagtcgg cttggggaag gactgaaggg cagctgccaa   1740
 gacctcagtt acctcctgac ctgagggtgg agagtggcag gaagcaagca tgtttgctgt   1800
 gcacttagga aaggctggtg agccagaggg actgatcagg ccccattcac tctctactca   1860
 ttaaaaggtc ctgagccacg aagcgcttcc cattttgaac tttctgtcct cacagattct   1920
 gtttgacaga atctaagggc catcagggaa ctcttttcat cttgcaaaga gaaaaagcca   1980
 gtctttccag aataaatatt catctgtttg aaataaa                            2017



      <210> 718
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 718
 tttcgtccaa gtaccaacac gaaggcttct acttcgttga gacgcccctg gccctggcag     60
 catggaccaa ccagcccgag attgggcagc tgctgatgga gcacgagcag acggacatca    120
 cctcgcggga ctcacgaggc aacaacatcc ttcacgccct ggtgaccgtg gccgaggact    180
 tcaagacaca gaatgacttt gtgaagcgca tgtacgacat gatcctactg cggagtggca    240
 actgggagct ggagaccact cgcaacaacg atggcctcac gccgctgcag ctggccgcca    300
 agatgggcaa ggcggagatc ctgaagtaca tcctcagtcg tgagatcaag gagaagcggc    360
 tccggagcct gtccaggaag ttcaccgact gggcgtacgg acccgtgtca tc            412



      <210> 719
      <211> 487
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(487)
      <223> n = a,t,c or g


      <400> 719
 ggagtcccng nngcccccca atgagaccct ggcagtgcgg ggaattccgt gcttcataaa     60
 gccgctttcg ccgctggctg tcgccgcgtt ttgcctccgc agcagctctg ggctcttctc    120
 agctgcgcga gcagctgctc caatgccccg gagtggccat gggcgccccg cactggtggg    180
 accagctgca ggctggtagc tcggaggtgg actggtgcga ggacaactac accatcgtgc    240
 ctgctatcgc cgagttctac aacacgatca gcaatgtctt atttttcatt ttaccgccca    300
 tctgcatgtg cttgtttcgt cagtatgcaa catgcttcaa cagtggcatc tacttaatct    360
 ggactctttt ggttgtagtg ggaattggat ccgtctactt ccatgcaacc cttagtttct    420
 tgggtcagat gcttgatgaa cttgcagtcc cttgggttct gatgtgtgct ttagccatgt    480
 ggttccc                                                              487



      <210> 720
      <211> 2095
      <212> DNA
      <213> Homo sapiens


      <400> 720
 tttttttttt ttgacacaat aacaaacacc tatttattat attaaatacc aggcctggaa     60
 atattaaggt accaaattac cagattccca agaaattaca tttcacatcc caaaatgtcc    120
 tgttggtgct ttgacaacta aaacaatgtt ttagaaagat tttgtttcag atccgtaaaa    180
 aatagcaaca atttggggga taaaaataag taaaatccaa aaacttcaaa agtttattcc    240
 aaattctttt gaatccttat ggtgggctgt aaaaccagtt tttaaatgct catagcttca    300
 gggatggggg agtatcacag tttatatgaa tttctgccta gggaagccca gcaatgttac    360
 acagtagttt cgtgtttcca taatccagtc ctaacattgc cagtgctatc ggtaccgagc    420
 aagggtccct cctgcccatt gcttttaatt ggtccattct gaatggccaa gttgaggcca    480
 taagattttt gctgattttc aagttcaacc acagctggct tccttaacgc atctttttta    540
 ctagtggttg aaactggctt ttcaaaattt ctgctacttt tgggaagtgt gctacaagca    600
 tcgctgctgt cttgctgggg tgggttgtac tgtctctctc tgtaggctaa ataagctctt    660
 cggctcctcg agtgtccttc gttattgccc agccggcttt taggtaagcc gttctgcacg    720
 cttccttcca cgctcgttgg gacatcgtag gcatattctc tcaggactgt gagtcggctt    780
 gcccggtgtc ctttacttct gtttttatgg tggcggcttg agtgcacatt tgttcgaaac    840
 tgaacttcta aaggcgccac gtgcatttta atatcattgt ccattgaatg ttctgtcaga    900
 ctattatcaa gctgaggggt ggagttcaaa ggtaaagaat tggcatggca ctgagctgca    960
 gccgcctgca agtttgttaa tttgcagccc tgggaggaat ttttgaagct tgaagcactt   1020
 ttgtttgtgc atgaagactc cgcactgcta ttggggcatt tgggtgcctc tccattcgtc   1080
 ccattagagt tggggggctg gacgttgact tgcactgaat acgagctccg tcctgggcag   1140
 caagtcatga tccacgcaag tctaacatcc tccctattaa cacaatggtg gaccacgaag   1200
 aacgcactga agcttaaact tgtggctcca aaaacgaagc taaaaaccaa gtccaaaggg   1260
 taatacaaag aaacagccaa agccccaaac atccacagtg caacatataa gagcaaagta   1320
 aggctggccc ccaagagctg agaatgaaaa gtgtgctcat tttccaaggc tgatgtagaa   1380
 atcagagaca aagacattga atcctgatga tttatttcgc cattttcatt ggctgccaat   1440
 ctctgttgct cctccgtggg ctccttaagc tcatatttgc gctcagggtg tcttttcaac   1500
 tgaataaata tgctcagaaa gtacatgcag tttacaaaag tgatgaagct ggctggccca   1560
 tagaaggctc ccaaggaggg ttcccatgcc atccaggcaa tagggtgcgt ttggccgact   1620
 gccgtaattc ttaatgttcg ctgctgcagt tatgcccgca aacaatgatg gggataccca   1680
 cccaccaatc aggtaaaatc tgagcattgg tcttggtgga ggtggtggtt catcaggatc   1740
 ctggcatctt ttagcttttt tagtgacttg tttgtagata tttcgagctg tcactcctac   1800
 ccatagtact gtggcaaggg tggaatagtg aagaattatc ccaactgctt ggcagatgct   1860
 ggcattccta gtctgggtta ttcctcccac aaagaccaca caggttagga aaatatgaaa   1920
 gcacaagttc acaagcatgt gccagctctt gaggctgatt ctaatcaaac tgtgatggta   1980
 tatgtaactg acaatgacgg ctaagagaca taagaggaga atgatagcgg tagtataaac   2040
 cacaggatgc aggaggctgg ccgcctgggt gtatagttca gatcccgtcc tgttc        2095



      <210> 721
      <211> 744
      <212> DNA
      <213> Homo sapiens


      <400> 721
 catcctggga acagtgtatc ttttgctgga gaaccatctc tgcgtgcaag agacggccgt     60
 ctcctgtgag agcttcatca tggagtcggc caatggctgg catgacatca tgttccagct    120
 ggagttcttt atgcccctcg gcatcatctt attttgctcc ttcaagattg tttggagcct    180
 gaggcggagg cagcagctgg ccagacaggc tcggatgaag aaggcgaccc ggttcatcat    240
 ggtggtggca attgtgttca tcacatgcta cctgcccagc gtgtctgcta gactctattt    300
 cctctggacg gtgccctcga gtgcctgcga tccctctgtc catggggccc tgcacataac    360
 cctcagcttc acctacatga acagcatgct ggatcccctg gtgtattatt tttcaagccc    420
 ctcctttccc aaattctaca acaagctcaa aatctgcagt ctgaaaccca agcagccagg    480
 acactcaaaa acacaaaggc cggaagagat gccaatttcg aacctcggtc gcaggagttg    540
 catcagtgtg gcaaatagtt tccaaagcca gtctgatggg caatgggatc cccacattgt    600
 tgagtggcac tgaacaagca gaccaacaac actgaggaag atagagtggt gacttagaat    660
 taactcgtgc taaggggtcg ggggctttga aaatgccacc cccctttctt attgcaagac    720
 ggcttctcgc acatgaactg catc                                           744



      <210> 722
      <211> 411
      <212> DNA
      <213> Homo sapiens


      <400> 722
 tttttttttt ttcctgagat ggagctttgc tgttgttgcc caggctgtta gtgcaatggc     60
 acaatctcag ctcactgcct tttgggttca agcaattctc ctgcctcagc ctcccaggtg    120
 gctgggactg caggcgcccg ccactacgcc cggctgattt tttgtatttt tggtggagac    180
 ggggtttcgc cgtgttcgcc aggatggtct ccatctcttg acctcgtgat ctgcctgcct    240
 cagcctccca gtgctgggat tacaggcgtg agccaccgcg cctggccaaa atatataacc    300
 ttaagtgtca tcaatactct ggctgaccat catcatcgtg ggactgactt tggtggaagt    360
 ccttggttac atgtcattat tgcatttccg acaagttata aagttgtcat t             411



      <210> 723
      <211> 2001
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2001)
      <223> n = a,t,c or g


      <400> 723
 cagcgtggcg gaattcctgg aaagttccag gaagactctg ggtctgtgga ctgggctctg     60
 gggccatttt ggggaatttt ccaggctgat tttggctgta tgcgatttta tctttctgca    120
 cagacatcag accctgtcct caggatgtga tggggcccct cccccatctc ccatcctacc    180
 agcctgtgtc caggtggggg tggggcaggg cagacaacag ggtccctgtg tctcgggcag    240
 caatgctgcc ccctttcctg ccccaacatc cccagcagac acaagagatg gagactatga    300
 gctgctctcg tggctgggtc tcgggggtcc tgcaccctca ggagctgacg ctgacgcact    360
 ccactgcctg tcaccaggaa cctacctcgc gccatcttca tctccatccc actggtgacc    420
 ttcgtgtaca cgttcaccaa cattgcctac ttcacggcca tgtcccccca ggagctgctc    480
 tcctccaatg cgggggctgt gaccttcggg gagaagctgc tgggctactt ttcttgggtc    540
 atgcctgtct ccgtggctct gtcaaccttc ggagggatca atggttacct gttcacctac    600
 tccaggctgt gcttctctgg agcccgcgag gggcacctgc ccagcctgct ggccatgatc    660
 cacgtcagac actgcacccc catccccgcc ctcctcgtct gtgcccatca aggtgaacct    720
 tctcatcccc gtggcgtact tggtcttctg ggccttcctg ctggtcttca gcttcatctc    780
 agagcatatg gtctgtgggg tcggcgtcat catcatcctt acgggggtgc ccattttctt    840
 tctgggagtg ttctggagaa gcaaaccaaa gtgtgtgcac agactcacag agtccatgac    900
 acactggggc caggagctgt gtttcgtggt ctacccccag gacgcccccg aagaggagga    960
 gaatggcccc tgcccaccct ccctgctgcc tgccacagac aagccctcga agccacaatg   1020
 agatttttgt agagactgaa gcagttgttt ctgtttacat gttgtttatt gaggaggtgt   1080
 tttggcaaaa aagttttgtt ttgttttttt ctggaaaaaa aagaaaaaag atacgactct   1140
 cagaagcctg ttttaaggaa gccctaaaat gtggactggg tttcctgtct tagcactgcc   1200
 ctgctagctc ttcctgaaaa ggcctataaa taaacagggc tggctgttcg ctcgtgctat   1260
 ggggagtccc tgatgggcac agacgggagt ggctggggcg tacctcggtg ggtgcacaca   1320
 tgttgctggc caggaagatg ccgtggcagg ccctggagga ggctcttgac attagggggc   1380
 tttgctgctt gacacaggcg ctccctacca tggcacccag agtccccctg ccctaaaggg   1440
 atgtcgagga tggggtagca gctcagtccg cccctacccc aggcccctcg atgccagtct   1500
 gagctcggcc acccaggaga gctcaggggc tccaggctgg gattgtcttt cttcccgtaa   1560
 atcaccacag agtgaaggtc aggacttcag agcccacagt ctcaccctgg cttacaggtg   1620
 gggaaaccga ggccctgaga taggatggaa cagacgtggc cactgctgtt ggtgcctcgg   1680
 cctctctgtc cccagaaagc acagagcagc atgtcctggg ggctttgagg cctgcaggga   1740
 actccagggg cttcatgtac agcaggcaca caccccagcc cttccacggt gcccaggaga   1800
 ttggaccttc agggagggca aagggcgcct gcctggccag gggcatgagg gtttggcagg   1860
 agccacccaa cccaggtcct ccagaggcct tgctggacag gaagagggtg aggcgtgagc   1920
 aaaatagtca ccacggatga gacccagcgt cccgaattcc tccacatgga ctagtgatgt   1980
 cgaacaaann nnnttgtcct a                                             2001



      <210> 724
      <211> 2116
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(2116)
      <223> n = a,t,c or g


      <400> 724
 cggacgcgtg ggctggaaca aacatggccg ctctggcgcc cgtcggctcc cccgcctccc     60
 gcggtcctag gctggccgcg ggcctccggc tgctcccaat gctgggtttg ctgcagttgc    120
 tggccgagcc tggcctgggc cgcgtccatc acctggcact caaggatgat gtgaggcata    180
 aagttcatct gaacaccttt ggcttcttca aggatgggta catggtggtg aatgtcagta    240
 gcctctcact gaatgagcct gaagacaagg atgtgactat tggatttagc ctagaccgta    300
 caaagaatga tggcttttct tcttacctgg atgaagatgt gaattactgt attttaaaga    360
 aacagtctgt ctctgtcacc cttttaatcc tagacatctc cagaagtgag gtaagagtaa    420
 agtctccacc agaagctggt acccagttac caaagatcat cttcagcagg gatgagaaag    480
 tccttggtca gagccaggag cctaatgtta accctgcttc agcaggcaac cagacccaga    540
 agacacaaga tggtggaaag tctaaaagaa gtacagtgga ttcaaaggcc atgggagaga    600
 aatccttttc tgttcataat aatggtgggg cagtgtcatt tcagtttttc tttaacatca    660
 gcactgatga ccaagaaggc ctttacagtc tttattttca taaatgcctt ggaaaagaat    720
 tgccaagtga caagtttaca ttcagccttg atattgagat cacagagaag aatcctgaca    780
 gctacctctc agcaggagaa attcctctcc ccaaattata catctcaatg gcctttttct    840
 tctttctttc tgggaccatc tggattcata tccttcgaaa acgacggaat gatgtattta    900
 aaatccactg gctgatggcg gcccttcctt tcaccaagtc tctttccttg gtgttccatg    960
 caattgacta ccactacatc tcctcccagg gcttccctat cgaaggctgg gctgttgtgt   1020
 actacataac tcaccttttg aaaggggcgc tactcttcat caccattgca ctcattggca   1080
 ctggctgggc tttcattaag cacatccttt ctgataaaga caaaaagatc ttcatgattg   1140
 tcattccacg ccgagtcctg gcaaatgtag cctacatcat catagagtcc accgaggagg   1200
 gcacgactga atatggcttg tggaaggact ctctatttct ggtcgacctg ttgtgttgtg   1260
 gtgccatcct cttcccagtg gtgtggtcaa tcagacattt acaagaagca tcagcaacag   1320
 atggaaaagg caagttctct cgtgctcatt ttgtgttgct cagcttgctc tgaacccacg   1380
 tgctgcggca ctgcggagga gtggaggcag cctatggtgt caagatgctg tcttcctggg   1440
 aggagagcta ggggaggcct ggggcccact tcgtgagagc agccaggggt agtttggaga   1500
 aggaggtgtt gagtcagttg tataaggagg aggttgggng tgactgctgc ttattaagat   1560
 gattcatttc atttccactc gtggttgtga ttttcacctt ctcaaaactg agtcagcaag   1620
 agaaaatctt gtcttagaag ggccagataa cacttcgctg tgagaacagg agggataatg   1680
 gattggagat ggctatgtgt aaagcagccc tgcctgctga tttaacacac tttcaaaata   1740
 gatgtgtcag tattcattta aagcaagact ctgatgacag aaggaacctt gaaaactacc   1800
 tgatattgaa atggttgtgc cctttatagc ccttttgcat ctccttgact ttccagtcat   1860
 gcctcctaaa tcagaagaaa agctgcaaag aaaatgtttt gtgtggttct gggcttattt   1920
 gaataatgtt catgaccaca ggctgccata gcacaagtga gaatttcaga ccacaagggt   1980
 ttaaggagca gtgctctctt ctctcaaagc tcagaacggt ctctggatcc atggtatcgt   2040
 acacccagtg tggatattaa cattctttaa tgcaggttat gaataataaa taaaacaggt   2100
 ttttgctaat aaaaaa                                                   2116



      <210> 725
      <211> 570
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(570)
      <223> n = a,t,c or g


      <400> 725
 ggccncnnnn naaaatgatc tcttcggggg gaatattntc actatagcca atcccaccga     60
 tgttctaaag attcgaatgc aggctcaagg aagtttgttc caagggagca tgattggcag    120
 cttcatcgat atataccaac aggaaggcac caggggtctg tggaggagtg tggttccaac    180
 tgctcagcat gctgccatcg ttgtgggagt agagctacca gtctatgatt ttactaagaa    240
 gcacttaata ttgtcaggaa tgatggaaga cacaacttta actcactttg tttccagctt    300
 tacatatggt ttggctgggg ctcttgcctc taatccaggt gatgtggcag gcactcacgt    360
 gatgaaccag agggcaatcg tgggacatgt ggatctctat aagggcactt tggatggtat    420
 tttaaaaatg tggaaacatg agggcttttt tgtattctaa aggattttgg ccaaactggc    480
 tttggcgtgg acccttgaac atcattcttt anattacata tgagtagctc aagaggcttt    540
 anatctaagg actgaattat atgtgagccc                                     570



      <210> 726
      <211> 435
      <212> DNA
      <213> Homo sapiens


      <400> 726
 gctttaaatg attttattaa aaattgtacc aattgatggg gggaaagata tacacacata     60
 cacacatatg catgtgaaga acataaacac ataaagccaa aggtcctgta cagtttttta    120
 aaaaatgggg cccctttctt cttcctctct cccagaggca gagtgcccag accccagggc    180
 agctaccctg gggatgaaca aaatgctaca ttctcactgg gtctcctcga tagcccctgt    240
 ggatccaggg atggggtaga aggctgccag tggcccagac tttgaaacag gccaggcaga    300
 ggccaggctg agtcctccac cctcattgca ggagtccagc gtctggcctg gggacttccc    360
 tcaccagatc tgttgaccaa cttctagaaa cccctgcttt ggggttgtga attagaaggg    420
 ctgttttgac cctga                                                     435



      <210> 727
      <211> 1050
      <212> DNA
      <213> Homo sapiens


      <400> 727
 atggggatca cctgctggat cgccctgtat gctgtggagg ccctccccac ctgccctttc     60
 tcctgcaagt gtgacagccg cagcctggag gtggactgca gtggccttgg cctcaccacg    120
 gtgcccccag acgtgcccgc agccacccga accctcttgc tcttgaacaa taagctgagt    180
 gccctgccaa gctgggcttt cgccaacctc tccagcctgc agcggttgga cctgtccaac    240
 aacttcctgg accggctgcc ccgctccatt ttcggggacc tgacgaatct gactgagctt    300
 cagctgcgca ataacagcat caggaccctg gacagggacc tgctgcggca ctcgccgctg    360
 ctccgccacc tggacctgtc catcaacggc ctggcccagt tgccccctgg tcttttcgac    420
 gggctcctgg ctctgcgctc cctctcgctt cgctccaacc gtctgcagaa tctggaccgg    480
 ctgacatttg aacccctagc aaacctgcag ctgctgcagg tcggggataa cccctgggag    540
 tgtgactgta acctgcgtga gttcaaacac tggatggagt ggttctccta ccgaggggga    600
 cgcttggacc agcttgcctg caccctgccc aaggagctga gggggaagga catgcggatg    660
 gtccccatgg agatgttcaa ctactgctcc cagctggagg acgagaatag ctcagctggg    720
 ctggatattc ctgggccacc ctgcaccaag gccagtccag agcctgctaa gcccaagccc    780
 ggggctgagc cggagccgga gcccagcaca gcctgcccac agaagcagag gcaccggccg    840
 gcgagcgtga ggcgagccat gggcacggtg atcattgcag gggtcgtgtg cggcgtcgtc    900
 tgcatcatga tggtggtggc cgctgcctat ggctgcatct acgcctccct catggccaag    960
 taccaccggg agctcaaaaa gcgccagccc ctgatggggg accccgaggg cgagcacgag   1020
 gaccagaagc agatctcttc tgtggcctga                                    1050



      <210> 728
      <211> 920
      <212> DNA
      <213> Homo sapiens


      <400> 728
 ccttcccggg tcgacgattt cttggcgggt acccgtgcgc ggtgggctga tcgcggctct     60
 cttaccttct cgggcagccc agtctttgcc atccttgccc agccggtgtg gtgcttgtgt    120
 gtcacagcct tgtagccggg agtcgctgcc gagtgggcgc tcagttttcg ggtcgtcatg    180
 gctggctacg aatacgtgag cccggagcag ctggctggct ttgataagta caagtacagt    240
 gctgtggata ccaatccact ttctctgtat gtcatgcatc cattctggaa cactatagta    300
 aaggtatttc ctacttggct ggcgcccaat ctgataactt tttctggctt tctgctggtc    360
 gtattcaatt ttctgctaat ggcatacttt gatcctgact tttatgcctc agcaccaggt    420
 cacaagcacg tgcctgactg ggtttggatt gtagtgggca tcctcaactt cgtagcctac    480
 actctagatg gtgtggacgg aaagcaagct cgcagaacca attctagcac tcccttaggg    540
 gagctttttg atcatggcct ggatagttgg tcatgtgttt actttgttgt gagtgtttat    600
 tccatctttg gaagaggatc aactggtggc aggggttttg ttctttttat ctcctgctat    660
 gggtaggttt gctctctttt ccgcctgacc ccccttggaa aagctttaca cccgcgattc    720
 tttttcttgc ctgggggact ggctcttccc ccggccgcca tcgcttctcg ctccccacag    780
 accgccgccc gtctgctcac tcgccctttt tatcaaccct tcagcactcg atccgtactt    840
 tattccactc cccgatacgt tcatcacgtt tcgcattcgt ctcctctctc cactcgtaca    900
 cttcaatccc ttctctgccc                                                920



      <210> 729
      <211> 620
      <212> DNA
      <213> Homo sapiens


      <400> 729
 tttcgtggcc ggtcgggcag cgctgcggga gcagccgccg gcaccgccgc cttgcaccat     60
 cgcatcatgt ccgggcagct ggagcgttgc gagcgcgaat ggcacgagct ggagggagaa    120
 tttcaagaac tgcaggagac gcacaggatc tacaagcaga agctggagga gctggctgcg    180
 ctgcagacgc tgtgtagcag ttccatcagt aagcagaaga agcacctcaa ggacttgaag    240
 cttacactcc agaggtgcaa acgccatgcc agtcgggagg aggcggagct cgttcagcag    300
 atggcagcga acatcaagga gcggcaggac gtcttcttcg acatggaggc ctacctgccc    360
 aagaagaacg ggctctactt gaacctggtc ctcggcaatg tgaacgtgac cctcctcagc    420
 aaccaggcca agttcgccta caaggacgaa tatgagaagt tcaagctcta cctgaccatc    480
 atcctgctcc tgggtgccgt ggcatgtcga tttgtccttc actacagggt gactgacgaa    540
 gtcttcaact tcctgctggt gtggtattac tgcaccctga ccattcggga gagcattctc    600
 atcagcaacg gctcaagaaa                                                620



      <210> 730
      <211> 3294
      <212> DNA
      <213> Homo sapiens


      <400> 730
 atgtgcggcc cgcggcggct cgcagctccc ggcagcagcc tcggcagctt cggccgcgcc     60
 tcgagaggcg gccgcagagg ctccagcggc ggccgagcgg ccgagcccgg gctgggagac    120
 accatgcgcc gcgtccttcg gctgctcctc ggttgcttcc tcaccgagct gtgcgcccgc    180
 gtgtgccggg cgcaggagcg agcgggacac gggcagctgg cgcaactggg cggcgtgttg    240
 ctgctggcgg ggggcaaccg ctccggggcc gcctccggag aggccagcga gggcgctgag    300
 gcatcggacg cgcccccgac ccgggcgccc acgccggact tctgccgggg ctacttcgat    360
 gtcatgggcc agtgggaccc gccgttcaac tgcagctcgg gcgacttcat cttctgctgc    420
 gggacttgtg gcttccggtt ctgctgcacg tttaagaagc ggcgactgaa ccaaagcacc    480
 tgcaccaact acgacacgcc gctctggctc aacaccggca agccccccgc ccgcaaggac    540
 gaccccttgc acgaccccac caaggacaag accaacctga tcgtctacat catctgcggg    600
 gtggtggccg tcatggtgct cgtgggcatc ttcaccaagc tggggctgga gaaagcgcac    660
 cggccccaaa gggagcacat gtccagcctc tccgctgggg gatgtcaccg ggaagccaac    720
 ttcggcttgg aacacggaga aggggcgctg ggctcagcac agggggtatc cctctcccgg    780
 tcccgcagcc ccgcttgttc tccgctcttg gccaatccca ctgtttcggc ccccgcctct    840
 gttgccactt tcctcaccag catggatctt gccctctcct ttgtgtcact cactaaaggc    900
 tcaaagtctg gttcaagcaa cgatttgatc aacgaattta acagcccgca atgcatgctc    960
 tgtaccgatg accgtaaccc gtgggagatc gcccatgaag gacacatcga tgccttaatt   1020
 cgccgcctga tcgaacaaca caatgtgccg ctgcatgtgg catatcgcgt cgccagctgg   1080
 tcgacggcgc gccactttgg tctgaatcac ctcggcttac tggcacccgg caagcaggcc   1140
 gatatcgtcc tgttgagcga tgcgcgtaag gtcacggtgc agcaggtact ggtgaaaggc   1200
 gagccgattg atgcgcaaac cttacaggcg gaagagtcgg cgagactggc acaatccgct   1260
 ccgccatatg gcaacaccat tgcccgccag ccagtttccg ccagcgactt tgccctgcaa   1320
 tttacgcccg gaaaacgcta tcgggtcatt gacgtcatcc ataacgaatt gattacgcac   1380
 tcccactcca gcgtctacag cgaaaatggt tttgatcgcg atgatgtgag ctttattgcc   1440
 gtacttgagc gttacgggca acggctggct ccggcttgtg gtttgcttgg cggctttgga   1500
 ctgaatgaag gtgcgctggc tgcgacggtc agccatgaca gccataatat tgtggtgatc   1560
 ggtcgcagtg ccgaagagat ggcgctggcg gtcaatcagg tgattcagga tggcggcggg   1620
 ctgtgcgtgg tacgtaacgg ccagaaatta ctcttcagaa tccccagctt cagcatcatc   1680
 agcggtttcg tttgcgaaat catcgcgacg ctcacggcgc tcgtctttcg ctttaaccat   1740
 cggagatgct tcggtaacag cgtgcttggt acgcataacc atgctgcgga taacggcatc   1800
 gttgaagcgg aaggtagttt ccagctcatc gatcacttcc tgcggagctt caacattcat   1860
 cagaacgtag tgtgctttgt gcagtttgtt gatcgggtaa gccagctgac ggcggcccca   1920
 gtcttccaga cggtggatct tgccttctgc accagtgatg gcagcagtgt agcgctcgat   1980
 catgcccgga acctgttcgc tctgacagaa gggaataaaa taaaaaatcg tcgcgaggaa   2040
 aaacatcggt gccgaggcca gtccaagctc aatattatta ttgataacgt tgttaaagct   2100
 gtaaacggcg gcaaaagtca gcgagagcaa gccgaatttg ccgattgtat tacgtttggt   2160
 atcagacata acacatctcc gaaaatgagt aggttgttat ttgttatgga aataaccatc   2220
 ttcgatggtg actttgagaa ccactttttt gaccgcgtta ttgcagataa accgatacgc   2280
 ttcatggata tcgcaaataa cgatttgccc ttcgtggacc tcaacgaaca gttggataaa   2340
 tatgtcgcta atggcggcaa acgtagcgac tggacggtga aattcgccga aaaccgcagt   2400
 caggacggaa cgttgctggg ctactcgcta ttgcaggagt cggtggatca ggccagctat   2460
 atgtacagcg ataaccatta tctggcggag atggcaacca tcctcggtaa gccagaagag   2520
 gccaaacgct atcgccagtt ggcacagcag ctcgcggact acatcaacac ctgtatgttc   2580
 gacccgacta cccagttcta ctatgacgta cgtattgaag ataaaccact ggcgaacggc   2640
 tgcgcgggca aaccgattgt tgagcgcggt aaagggccgg aaggctggtc gccgctgttt   2700
 aacggtgcgg caacgcaggc caatgccgac gcggtggtga aggtgatgct cgatcctaaa   2760
 gagttcaaca cctttgtccc gctgggaacg gcggcgttaa ccaatccggc ttttggcgct   2820
 gatatctact ggcgtgggcg cgtatgggtg gatcagttct ggtttggtct gaaagggatg   2880
 gagcgttacg gttatcgtga tgatgccctg aagctggcgg atacgttctt ccggcacgcc   2940
 aaagggttaa ccgccgatgg accaattcag gaaaattaca acccgctgac aggcgcacag   3000
 caagcacacc agatgtcagt gcgcgagttg tacaccgatg tcatcgaaga gttttactgg   3060
 gttgcgctcc cgcttacgac gcaaaattcc ctttcacaat accaacccga atggcagtgc   3120
 tgggaacctg atgtcgaatg gccaggcatg accttcgaac aatttgtacg tgagtttgcc   3180
 gaatggatca gcctatcgat tcattactgt tacccggagt atgctcataa ggtgtttcac   3240
 agacagtact ggcgtaataa atgggcaact tcatctgacc tagcaatccc atga         3294



      <210> 731
      <211> 881
      <212> DNA
      <213> Homo sapiens


      <400> 731
 cgcgtggggg ttttatatgg acctttggaa ggctgtttat ttacccaatg gaagaaatcc     60
 ttcatttctg atttcgagct ggcatcgtga cacatttgga cctcagaaag actcttctca    120
 agttgaggag ggggatgatg ttcttgacaa attacttgaa aacattggcc atacaagtcc    180
 tgaatgcctt ttaccgtcac agctaaatct aaatgaacct tccctaaccc catgtggcat    240
 gaactatgac caagagaagg aaatcattga ggtcattttg cgccaaaatg ctcaagagga    300
 tgagtatatc cagagtcata acttcgattc tgcaatgaaa gtcaccagcc aagggcagcc    360
 ctccccagtg gagcctcgag gaccctttta tttctgcagg ttattgcttg atgacttggg    420
 aatgaattct tgggacagaa ggaagaattt tcatctattg aagaaaaatt caaaattatt    480
 gagagagctg aaaaatttgg actcccgcca gtgccgtgag acacacaaaa tcgcagtgtt    540
 ttacattgct gaaggtcaag aagacaagtg ttcaatcctc tctaatgaaa gaggaagcca    600
 agcatatgaa gactttgttg ctggacttgg atgggaggta atgcatttca ttcaggaggt    660
 gtttattgac cagcactgtt taaagatgtg tccaaactag acattgtgta agtttttaca    720
 tgtgcttttg cattcaaata tagcatagat agagttctgg aattgaagaa tttattggat    780
 ttgacatctg ttagttgctt gtcagtattt aatacatgaa cttttgtttt cctttaactt    840
 tcctcttaat attttttcat ttgcttttta tcagaactga a                        881



      <210> 732
      <211> 396
      <212> DNA
      <213> Homo sapiens


      <400> 732
 ggcgctggtg cccctttccc ctatctaagc cccacggtcc tcctgctggt cagctgtgac     60
 ctgggcttcg tgcgagcaga ccggcctccc tctcctgtga atgtgacggt cactcacctc    120
 agagccaact cggccactgt gtcctgggac gtcccagaag gcaacatcgt cattggctac    180
 tccatttccc agcaacggca atggccccgg gcagcgtgtg attcgggagg tgaacaccac    240
 cacccgggcc tgtgccctct ggggcctggc tgaagacagt gactacacag tgcaggtcag    300
 gagcatcggc cttcggggag agagtccccc agggccccgg gtgcacttcc gaactctcaa    360
 gggttctgac cggctacctt caaacagttc aagccc                              396



      <210> 733
      <211> 381
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(381)
      <223> n = a,t,c or g


      <400> 733
 tctcncgcca gaatcctgat agtcaggatc aaagagaatg gcaccggtga acacagatgc     60
 cacagataaa gacatatcca agttcaaggt cacctccact ttggtggtct ccggaataga    120
 gtgcatcact ggcatccttg ggagtggctt catcacggcc atctatgggg ctgagtgggc    180
 caggggcaaa acactcccca ctggtgaccg cattatgttg atgctgagct tttccaggct    240
 cttgctacag atttggatga tgctggagaa cattttcagt ctgctattcc gaattgttta    300
 taaccaaaac tcagtgtata tcctcttcaa agtcatcact gtctttctga accattccaa    360
 tctctggttt gctgcctggc t                                              381



      <210> 734
      <211> 386
      <212> DNA
      <213> Homo sapiens


      <400> 734
 accagaccgc cctgttcttc cgcgtggctg agtgggattc caccgagaag atcggggacc     60
 tcttcgtggc ctcgttttcc aagaccatgg cgctagaggt gtacagagac tacgtgaaca    120
 acttcaccag tgccatgtcc atcataaaga agggctgcct aaccaagcct gccttccttg    180
 agtacctcaa gcgacggtag gtgtgcagcc cataccgtgt caccctctac gggctgatgg    240
 tcaagcccat ccagaggttc ccacagttca tactcctgct tcaggacatg ctgaagaaca    300
 cccccagggg ccatccggac aggctgtcgc tgcagctggc cctcacagag ctggagacgc    360
 tggctgagaa gctgaacgag caaaaa                                         386



      <210> 735
      <211> 1151
      <212> DNA
      <213> Homo sapiens


      <400> 735
 tcaaacagct gcatctgatt tgccaacaag atttcttact gttatggttg ctagatagcg     60
 atcatttgtg atatttactg gcagttttgt ggcattaact gtgtaatttt gtaaatgtga    120
 tttccatctt gtgagagtca cttcataatc caagattttt ccattggctt caaaaggagg    180
 caatgtaaaa tcttcctcat tgactgatga aacttgcttt gacctttcaa aatgtgaaat    240
 atctggactg gattcatgct gactgcagtt ctgtttgaag tactgttgcc tgggcaaaat    300
 accatcaccg ccatctacat gatctactaa ttgtagatct tctggccgct cctctgaatc    360
 taacaagggc tgggtagact cggatcttga gaagacttgg actgacggaa cttggtgtct    420
 gtagcccact gtgtaccacg gtagaatact ggacagtgcc tcgaagtgtt ttgtgaagat    480
 tcattttcat cactgctaga aatgcttggc ctagaagatg acatgcatga agacccccca    540
 ataccactgc tgtgtccttc agtattaatt ttttcctttt tgaacaggtc caatgatttc    600
 agatcttctg gaaaaggctt tttgtcattt gcttctattt ccacaacact tacatcagtg    660
 aaattgccat ctgaatacat tctgttcata taagcaagct ctgccaaaca ccgagcacta    720
 tgctgggcca ggagaggact gagctggggc cctctctcca gaggcccagc agtaggtgcc    780
 aggatataga aggcccttaa ctcaggggga aggagagaga agaatggaag atttccctca    840
 agagggtatc tatttgagtt gatttttggt gaaccagtaa gaatttccca gcttaacagg    900
 gactggggac tggagaacat ttgtttcctt ttccccacag ggtcttgtcc attcataccg    960
 ccttctttgg cataagcctg gatggaatat ggctcgccaa ctttgtcatg caacattgga   1020
 tacacagaga tgttatagca ccagaaaggt tttaatttat cttgctggat cgtccagttc   1080
 gtggcctgag acacagattc ccaggaaagg gtggtgggct ctgagtccac atccggaaac   1140
 cattcaatca t                                                        1151



      <210> 736
      <211> 2291
      <212> DNA
      <213> Homo sapiens


      <400> 736
 atgctggtct tgaactcctg ggctcaagtg atccactggc ctcagcctcc caaagtgctg     60
 ggattacagc ctttggaaaa aacccagtac ggcttcctag gaacagatcg tgtagaagag    120
 aaaacttcag tgataaccat cagagttagt gtgacccaca gacacaacag ctacatggaa    180
 gcagaaaacc ttacagaatt atcaaaattt ctcctcctgg gactctcaga tgatcctgaa    240
 ctgcagcccg tcctctttgg gctgttcctg tccatgtacc tggtcacggt gctggggaac    300
 ctgctcatca ttctggccgt cagctctgac tcccacctcc acacccccat gtacttcttc    360
 ctctccaacc tgtcctttgt tgacatctgt ttcatctcca ccacagtccc caagatgcta    420
 gtgagcatcc aggcacggag caaagacatc tcctacatgg ggtgcctcac tcaggtgtat    480
 tttttaatga tgtttgctgg aatggatact ttcctactgg ccgtgatggc ctatgaccgg    540
 tttgtggcca tctgccaccc actgcactac acggtcatca tgaacccctg cctctgtggc    600
 ctcctggttc tggcatcttg gttcatcatt ttctggttct ccctggttca tattctactg    660
 atgaagaggt tgaccttctc cacaggcact gagattccgc atttcttctg tgaaccggct    720
 caggtcctca aggtggcctg ctctaacacc ctcctcaata acattgtctt gtatgtggcc    780
 acggcactgc tgggtgtgtt tcctgtagct gggatcctct tctcctactc tcagattgtc    840
 tcctccttaa tgggaatgtc ctccaccaag ggcaagtaca aagccttttc cacctgtgga    900
 tctcacctct gtgtggtctc cttgttctat ggaacaggac ttggggtcta tctgagttct    960
 gctgtgaccc attcttccca gagcagctcc accgcctcag tgatgtacgc catggtcacc   1020
 cccatgctga accccttcat ctacagcctg aggaacaagg atgtgaaggg ggccctggaa   1080
 agactcctca gcagggccga ctcttgtctc ttacggtgtc cgagctacac agagccacag   1140
 aatctcacag gtgtctcaga attcctcctc ctgggactct cagaggatcc agaactgcag   1200
 ccggtcctcg ctgggctgtt cctgtccatg tacctggtca cggtgctggg gaacctgctc   1260
 atcatcctgg ctgtcagctc tgactcccac ctccacaccc ccatgtactt cttcctctcc   1320
 aacctgtcct tggctgacat cggtttcacc tccaccacgg tccccaagat gattgtggac   1380
 atgcaaactc acagcagagt catctcctat gaaggctgcc tgactcagat gtcttttttt   1440
 gtcctttttg catgtatgga tgacatgctc ctgagtgtga tggcctatga ccggtttgtg   1500
 gccatctgtc accccctgca ctaccgaatc atcatgaacc cacgcctctg tggcttctta   1560
 atcttgttgt ctttttttat tagtcttttg gactcccagt tgcacaattt gattatgtta   1620
 cagctcacct gcttcaagga tgtggacatt tctaatttct tctgtgaccc ttctcaactc   1680
 ctccacctta ggtgttccga caccttcatc aatgaaatgg tcatatattt catgggtgcc   1740
 atatttggct gtctccctat ctcagggatc cttttctctt actataaaat tgtttccccc   1800
 attctgagag ttccaacatc agatgggaag tataaagcct tctccacctg tggctctcac   1860
 ctggcagttg tttgcttatt ttatggaaca gggcttgtag ggtacctcag ttcagctgtg   1920
 ttaccatccc ccaggaagag tatggtggct tcagtgatgt acactgtggt cacccccatg   1980
 ctgaacccct tcatctacag cctgaggaac aaggacattc aaagtgccct gtgcaggctg   2040
 catggcagaa tcatcaaatc tcatcatctc catccttttt gttatatggg atagaaatgg   2100
 cagcaaaatt taacacctag gcctgcaaat tctgcctcct tggtcacatt attttggttg   2160
 cttgatggct ttcattcctc tctgggtttc gtatgtgaat attgcttgct ttgttttgtc   2220
 tttaattgca atgggtgagt attctggtat cctttgttca tcatacacat catgaatgat   2280
 tccaatataa a                                                        2291



      <210> 737
      <211> 377
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(377)
      <223> n = a,t,c or g


      <400> 737
 ntattttcat cccagttgtt caccgtggta agactacgct ggaaaactgt gtgctgcagt     60
 gtgagacgac cggagtcaca gtgcggacat cagcagagtt tctaatgaag aactcggatt    120
 tatatggcgc caaggtagaa gctcttgtcc tcttggggaa gtagtttgtg tttaagttgt    180
 aaatgaatat atgaaatatg ggaccaagat gtatgtgtgt actcccactc tcttcagaca    240
 gtcatctcta ccaagtcagt caaactcaac tgtgcaaggg tcttctcatg tagcattttc    300
 aaatgatagg aagaaaagta atacatctca caatgacttt atgtagcttt aagagaggtt    360
 tagaccctta aaattat                                                   377



      <210> 738
      <211> 818
      <212> DNA
      <213> Homo sapiens


      <400> 738
 ctattcagtg tggtggaatt cctcttctgc cccttccttc cccgctcagc atggcccctg     60
 tgtgcagttt caggctggcc cgcctgtcca gctggcgggt tcatgcgggg ctggtcagcc    120
 acagtgccgt caggccccac caaggggctc tggtggagag gattatccca caccccctct    180
 acagtgccca gaatcatgac tacgacgtcg ccctcctgag gctccagacc gctctcaact    240
 tctcagacac tgtgggcgct gtgtgcctgc cggccaagga acagcatttt ccgaagggct    300
 cgcggtgctg ggtgtctggc tggggccaca cccaccctag ccatacttac agctcggata    360
 tgctccagga cacggtggtg cccctgctca gcactcagct ctgcaacagc tcttgtgtgt    420
 acagcggagc cctcaccccc cgcatgcttt gcgctggcta cctggacgga agggctgatg    480
 catgccaggg agatagcggg ggccccctag tgtgcccaga tggggacaca tggcgcctag    540
 tgggggtggt cagctggggg cgtggctgcg cagagcccaa tcacccaggt gtctacgcca    600
 aggtagctga gtttctggac tggatccatg acactgctca ggactccctc ctctgagtcc    660
 tgctgtttcc tccagtctca ctgcacacca ctgcctcatg cttcctgggg cctccagcag    720
 ctccactaat ggaggagagg cagtagcctc cgacacagaa cgcatgggac ctctactact    780
 gtgtgtgagg aacagtcact acccactggc cagccact                            818



      <210> 739
      <211> 749
      <212> DNA
      <213> Homo sapiens


      <400> 739
 gaattcccgg gtcgacgatt tcgtggcagc aggagcctgg gactcgggag cgggacccgg     60
 acaaagccac ccgcttccgg atggaggagc tgagactgac cagcaccacg tttgcgctga    120
 cgggagactc agcacacaac caagtcatgg tccactggtc tggccacaac agcagcgtga    180
 ttctcatttt gacaaagctc tatgactata acctggggag catcacagag agctcgcttt    240
 ggaggtcaac cgattatgga acaacctatg agaagctgaa tgataaagtt ggtttgaaaa    300
 ccattttgag ctatctctat gtgtgtccta ccaacaagcg taagataatg ttactcacag    360
 acccggagat tgagagcaag ttattgatca gctcagatga aggggcaact tatcaaaagt    420
 accgggtgaa cttctacatt caaagcttgc tttttcaccc caaacaagaa gactggattc    480
 tggcatacag tcaagaccaa aagttataca gctctgctga atttgggaga agatggcagc    540
 ttatccaaga aggggttgta ccaaacaggt tctactggtc tgtgatgggg tcaaataaag    600
 aaccagacct tgtgcatctt gaggccagaa ctgtggatgg tcattcacat tatctaactt    660
 gccgaatgca gaactgtaca gaggccaaca ggaatcagcc ttttccaggc tacattgacc    720
 cagactcttt gattgttcag gatcattat                                      749



      <210> 740
      <211> 1297
      <212> DNA
      <213> Homo sapiens


      <400> 740
 cggacgcgtg ggcaagccag gaaggccctg gagaatccgg tgtgccccct cctccggcag     60
 agcttgggcc tgggctcacg aggaaggggc tgcagttctc caaggattcc cgcctgctcc    120
 cagacccccg ggagtcgtag gaacccgttc ctggacgctg acgtcggctt tcagggatcc    180
 ctcgccggac gccgcggagg gacagagcct gggaagccgt cgccccgccc cgtccccgcc    240
 cccgcgcgca gtgggcccgg ggcgctgaga cccgcgtaga gcaaagcgca aggtcccagc    300
 gccccttgga tcctcggtgg cagggtccgg gcaagtgtca ttgcgagggt tcaggaagcc    360
 ccggcctgtg atcgtgagcg gaaacccctc ctggagtttc cccaaagcca tggacagccc    420
 tagtcttcgt gagcttcaac agcctctgct ggagggcaca gaatgtgaga cccctgccca    480
 gaagcctggc aggcatgagc tggggtcccc cttaagagag atagcctttg ccgagtccct    540
 gaggggtttg cagttcctgt caccgcctct tccctccgtg agcgctggcc tgggggaacc    600
 aaggccccct gatgttgagg acatgtcatc cagtgacagt gactcggact gggatggagg    660
 cagccgtctt tcaccatttc taccccacga ccacctcggc ttggctgtct tctccatgct    720
 gtgttgtttc tggcccgttg gcatcgctgc cttctgtcta gcccagaagc atccccagtg    780
 cctgacctat agtaggtgct acgtatctgc ttttggaata catgcatgaa tgaatgaatg    840
 ggtatgttgg gtgggggagg gaccagggga agggtctggg actgagggga tgcctgggtc    900
 actgctgccc actgcctcta cagaccaaca aggcttgggc caagggggac atccaggggg    960
 caggggccgc ctcccgccgt gccttcctgc tgggggtcct cgccgtcggg ctgggcgtgt   1020
 gcacgtatgc ggctgccctg gtgaccctgg ccgcctacct tgcctcccga gacccgccct   1080
 agttgcccct acagccctca ctgtgaaccc tgaggccggc agcccagcaa atctgtgggc   1140
 agagagtgga gaatcttggt ggatgaggct gcggcggcgg caggagcatc tagaaacggg   1200
 agcgagctgg actggaaccc ttccccttcc tggccaccgc tcttcgggcg gcagcaacct   1260
 gagattaaac accagacacc cttgcagcca aaaaaaa                            1297



      <210> 741
      <211> 1044
      <212> DNA
      <213> Homo sapiens


      <400> 741
 ttttttcaat attacaacaa tctttattgg aaaaccccaa gtattttgtc ttgaaaaatc     60
 agcaatccag gtattaaaaa tagcatggaa tgcccaattt tactttgata attacatggt    120
 agtcagtttc cgctcctggc taaagccttg gattttcttc tgggcagttc ctaaaggcac    180
 aggtggcatg gaagaaatca ttccattttc gtctcctccc cttatttgat tggggtgtct    240
 ggttaccaaa aagagtcatc aggcccttgg attaccttct tgaactgatc ttctagatcg    300
 caagtcaaga ctgccatcat gttcccccaa atgcaaaaag ccttgttgct ccacctctct    360
 cctttccaga acaagtgagc tggggtttgc tttcttctcc atatcctgca gcttgatcaa    420
 tttttctatc aggaacattt tatctttgcc ctcattaatg atctgctcat ggagcagcct    480
 tatcataatc ttccttccct ctgtgatctg ccagtaaaga taggtgatga ttagcacaat    540
 gagggtgagg atgaaaaaga agtgcacact tccaatgagg ttccgataga tccaaacaac    600
 ccacaggtag ccaggccgtg tacttagggt gtcgatccag ctgtagatgg agtgaatgaa    660
 gagaggcaga cctcgaaaag ggccacagtc agctgaaggc ttcaatctcc agatggtgat    720
 ggccagggtg cacaagaccc cggtgaagga tgggaaaaag agcaagaaga tgaagaaagt    780
 catcatctgt gaggcccgcc aggctttgct cggaggctgg aaattcatca tcaggctgat    840
 atttttggag tagaccatga tgaaaagcat aatcatttgg ataaagggca gcagggggca    900
 aaagaatatg ccaatccacc ccagagtttg tgcatagatc agttgtagaa cgttcctggc    960
 aatgtcaaac tcctgaaggc caagacttgt gatcagttgc atcccaatga ttataatcag   1020
 caaaagcgtc gggccacgcg tccg                                          1044



      <210> 742
      <211> 767
      <212> DNA
      <213> Homo sapiens


      <400> 742
 ccccgatgag ctccccggtg cgcgagccgc cccagctgga ggaggagcgg caggtgcgga     60
 tcagcgagag cggccagttc agcgacgggc tggaggaccg aggcttacta gaaagcagca    120
 cccgcctgaa acctcacgaa gcccagaact acaggaagaa ggcattgtgg gtgtcctggt    180
 tctccatcat tgtcaccctg gccctcgcgg tggctgcctt tactgtctcc gttatgaggt    240
 acagcgcctc tgcttttggg tttgcatttg atgccatcct ggacgtcctg tcatcggcga    300
 ttgtcctgtg gcgttacagc aacgcggccg ctgtgcactc tgcccatagg gagtacatgc    360
 tgtataatca tggcaccaac atctgctgga cttctagtga gggcctgagg atgcttacaa    420
 tcatggtaga agatgacagt ttgttattcc attcaccagt agttggacat ttaggttatt    480
 tccagttttt gactattatg aaattagcag ctgagaacac tggtgtgcaa gtcttcgtgt    540
 ggacgtatgc cttcatttct cttggagtag aattgctgaa tcctatggtg gcccccaagc    600
 acatctgcca ggtagagtac catggggagg cctctgccct gagcatcatc acaggggcgc    660
 ctccagacct ggctgagaat agcctctgct tgggcctagg aagaagggca gaagtccaaa    720
 ggaaaccttg tccagtattg agtggaagtg cgccggagtt ccactga                  767



      <210> 743
      <211> 2168
      <212> DNA
      <213> Homo sapiens


      <400> 743
 gaattctcca ccacaacaaa cagcccactc ccatggccta cctggacaag ctggacctga     60
 cagacaacca tctgaccaca ctgcccctgg ctggacttgg gggcttgatg catctgaagc    120
 tcaaagggaa ccttgctctc tcccaggcct tctccaagga cagtttccca aaactgagga    180
 tcctggaggt gccttatgcc taccagtgct gtccctatgg gatgtgtgcc agcttcttca    240
 aggcctctgg gcagtgggag gctgaagacc ttcaccttga tgatgaggag tcttcaaaaa    300
 ggcccctggg cctccttgcc agacaagcag agaaccacta tgaccaggac ctggatgagc    360
 tccagctgga gatggaggac tcaaagccac accccagtgt ccagtgtagc cctactccag    420
 gccccttcaa gccctgtgag tacctctttg aaagctgggg catccgcctg gccgtgtggg    480
 ccatcgtgtt gctctccgtg ctctgcaatg gactggtgct gctgaccgtg ttcgctggcg    540
 ggcctgcccc cctgcccccg gtcaagtttg tggtaggtgc gattgcaggc gccaacacct    600
 tgactggcat ttcctgtggc cttctagcct cagtcgatgc cctgaccttt ggtcagttct    660
 ctgagtacgg agcccgctgg gagacggggc taggctgccg ggccactggc ttcctggcag    720
 tacttgggtc ggaggcatcg gtgctgctgc tcactctggc cgcagtgcag tgcagcgtct    780
 ccgtctcctg tgtccgggcc tatgggaagt ccccctccct gggcagcgtt cgagcagggg    840
 tcctaggctg cctggcactg gcagggctgg ccgccgcact gcccctggcc tcagtgggag    900
 aatacggggc ctccccactc tgcctgccct acgcgccacc tgagggtcag ccagcagccc    960
 tgggcttcac cgtggccctg gtgatgatga actccttctg tttcctggtc gtggccggtg   1020
 cctacatcaa actgtactgt gacctgccgc ggggcgactt tgaggccgtg tgggactgcg   1080
 ccatggtgag gcacgtggcc tggctcatct tcgcagacgg gctcctctac tgtcccgtgg   1140
 ccttcctcag cttcgcctcc atgctgggcc tcttccctgt cacgcccgag gccgtcaagt   1200
 ctgtcctgct ggtggtgctg cccctgcctg cctgcctcaa cccactgctg tacctgctct   1260
 tcaaccccca cttccgggat gaccttcggc ggcttcggcc ccgcgcaggg gactcagggc   1320
 ccctagccta tgctgcggcc ggggagctgg agaagagctc ctgtgattct acccaggccc   1380
 tggtagcctt ctctgatgtg gatctcattc tggaagcttc tgaagctggg cggccccctg   1440
 ggctggagac ctatggcttc ccctcagtga ccctcatctc ctgtcagcag ccaggggccc   1500
 ccaggctgga gggcagccat tgtgtagagc cagaggggaa ccactttggg aacccccaac   1560
 cctccatgga tggagaactg ctgctgaggg cagagggatc tacgccagca ggtggaggct   1620
 tgtcaggggg tggcggcttt cagccctctg gcttggcctt tgcttcacac gtgtaaatat   1680
 ccctccccat tcttctcttc ccctctcttc cctttcctct ctccccctcg gtgaatgatg   1740
 gctgcttcta aaacaaatac aaccaaaact cagcagtgtg atctatagca ggatggccca   1800
 gtccctggct ccactgatca cctctctcct gtgaccatca ccaacgggtg cctcttggcc   1860
 tggctttccc ttggccttcc tcagcttcac cttgatactg ggcctcttcc ttgtcatgtc   1920
 tgaagctgtg gaccagagac ctggactttt gtctgcttaa gggaaatgag ggaagtaaag   1980
 acagtgaagg ggtggagggt tgatcagggc acagtggaca gggagacctc acagagaaag   2040
 gcctggaagg tgatttcccg tgtgactcat ggataggata caaaatgtgt tccatgtacc   2100
 attaatcttg acatatgcca tgcataaaga cttcctatta aaataagctt tggaagagaa   2160
 aaaaaaaa                                                            2168



      <210> 744
      <211> 481
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(481)
      <223> n = a,t,c or g


      <400> 744
 ggaggaaaat cgagactgag atcctaggcc angncgngga attccactga cttcatgggc     60
 caggtcatct tcgaaggcga ccccaaggcc ccctctaact cgaccgcctg gcaagcctac    120
 aacgccgggg tcaagatggg ctgctggggc ctggtcattt atgccgccac tggtgctatt    180
 tgttcagccc tgttacagaa gtacttggac aactacgacc tgagcgtcag ggtgatctac    240
 gtgctgggga cgctgggctt ctctgttggc acagccgtga tggccatgtt tcccaacgtc    300
 tacgtcgcca tggtcaccat cagcaccatg ggcatcgtct ccatgagcat ctcctactgc    360
 ccgtacgccc tgctgggcca gtaccatgac atcaagcagt acatccacca cagccccggg    420
 aactccaagc gagggtttgg catagattgt gccatcctgt cctgccaagt gtacatctcg    480
 n                                                                    481



      <210> 745
      <211> 469
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(469)
      <223> n = a,t,c or g


      <400> 745
 cttacatctt caccattctc aacaccctcc agggcgtctt catcctattg tttggttgcc     60
 tcatggacag gaagatacaa gaagctttgc gcaaacgctt ctgccgcgcc caagccccca    120
 gctccaccat ctccctggcc acaaatgaag gctgcatctt ggaacacagc aaaggaggaa    180
 gcgacactgc caggtgagaa ctaggctttc tcaggggcag cgtaagcagg gtggattgag    240
 gacggtgtgg caaagggcct cctggcaaag tgctggagag aagcctcctc tttctatacc    300
 cagcccacac caaagggtag gaaacaggtt tttctagggt agccattgct agatggctgg    360
 gagacggtgg aaccgtcaga gagcagaaaa catagcccct tatcttaaat tccaagaaag    420
 caagaagttt caccaccacc tgtattagnc cggtgggtat accgaggac                469



      <210> 746
      <211> 1003
      <212> DNA
      <213> Homo sapiens


      <400> 746
 agaagctttg tcaatggggc attcatccaa cccaggtgac ctacaatagc agtgacgttt     60
 gatgggagag aaatgggtag tctatagaca catttgtaca aacgacctac tgtgtggaaa    120
 gctttaggct acatgatgcg ggcgctctcc tccccactct cattccccac aatgaggcag    180
 tatagcgggt gggtcaccac cccccctctg taaggcaccc gcatcagggg catcctggtt    240
 ggcttcggga tccagttcag ctccatctct ggagttcttg cgtggcattt ccaccagggg    300
 gagcccctgc aggtcttcct ccctctgacc aagatccggg gcctcctctg gccatctcac    360
 caacccattg gcctcctcca tgtggccagc cctgtaagac catcgcggct catggcaacg    420
 gacacaccag aactggaggc agatgaaggc caagacggct gtgaagcagg ccagcagaat    480
 ggccatcagc acccaaaggg agatctgggg gtctaccagg gagcttccag gagccagcgg    540
 actcttatcc agggtgtgga acatggtgca gtagtgcctg taagggaagg cagccttctt    600
 acagctgatg cacaggaagt agagagtgga aggggcaaga tgttccagca ccacggagct    660
 gatcgttcga ggcaccttct cctccgtggt ggaagctgta gcgaagatag ccagagaaga    720
 tgctgttcca gttgggcctg tacataatat ggtaatagtc ctccaggcag ggctccgagg    780
 acgaccagga gatgatggct cctgtataag aaatgttccc cacctcgatg ttcatgccga    840
 ttttgatgcg ggcagcgagt ctggttagag ctctgccctc cgaggtgcag tagactatag    900
 ctgagagatt ggggccttca tactcctgtg ctgtggtcgc tcggtggtgt ctctctgcgt    960
 gcgcgtgggt cggcccgaga aattccgggc cggtactcac gct                     1003



      <210> 747
      <211> 1478
      <212> DNA
      <213> Homo sapiens


      <400> 747
 gcctgtatcc cgtgctgttt ccctggcaga cacacaggcg ctcacgagtc tctccttgcc     60
 agcctgcagg gcggcgaccc ccaaaaccca gctccgggtc ccaacctagg caagaagctg    120
 cttctctgcc aacagctcct cttcggcctc cgtcacagcc acctggaccc taccctttcg    180
 cgactgctgc tgctgctgcc cggacgtgga agcagcaaga ggcgcttggt caagacacac    240
 tgacggtacc tacagaatac tggacatacg gattcagaat ccataaggct ttatcacctt    300
 gaatcaagga tttatttgat atcatcctcg gtctttactt cctatcaagt aacattgttt    360
 tgaaaaatag agttaacaca tttgccataa gggagttttt tttttttttt taaatacttc    420
 gcatactctc caatgcccaa aaatagcaag gtggtaaaaa gagaattaga tgatgatgtt    480
 actgagtctg tcaaagacct tctttccaat gaagacgcag ctgatgatgc ttttaagaca    540
 agtgaactaa ttgttgatgg ccaggaagag aaagatacag atgttgaagg gaagttctga    600
 agtcgaagat gaaagaccag cttggaacag taaactacaa tacatcctgg cccaagttgg    660
 attttctgta ggtttaggaa atgtgtggcg atttccatac ctatgtcaga agaatggggg    720
 cgttgtagaa ccagaatgtg aacaaagttc tgccaccacc tattactggt acagggaagc    780
 actgaatatt tcaagttcca tttctgaaag tgggggctta aactggaaga tgaccatctg    840
 cttgttggct gcctgggtca tggtttgctt ggctatgatc aaaggcattc agtcttctgg    900
 aaaagttaat acatatgata gagttactat gtcagcaact gtgttagcct tgcaggaaca    960
 atggcaaacc tttagcccga tcaggagtgg caatgggcac cttactggat caggagcaca   1020
 gcggacaccc tgccggatcc ggaggggtgg aagtcagtta cgggtctgcg atggcggcaa   1080
 acagcagtgg tggactgtca gccaaagctc agctcgagcc ataacaaaca cggaccagaa   1140
 gagtgtgcag ttgcaagatt taatagagtg aaaacagagc tcccatacaa agggaggtga   1200
 cccagagagg gtagccgttg ccagctcgaa tgcctgggtt taaatcccgg tcattgtccc   1260
 tcccgctgtg ctctcagaca atagatgatt ggctatttct ttacctcctg tttttgccta   1320
 atgagcgttt tagtgagctc tctttactac ctgattggtc gggtgtgagc taagttgcaa   1380
 gccctgtgtt taaaggtgga tgcagtcacc ttcccagcta ggcttaggga tttttagtca   1440
 gcctaggaca tccagctggt cctgtctttc aatatgtt                           1478



      <210> 748
      <211> 1404
      <212> DNA
      <213> Homo sapiens


      <400> 748
 ttccacaatc aactttggca tgttttgact ggcaggagct tcagctggtg taggcggtgc     60
 cagggacaaa gggggaaaag tgccccggcc tctgggagaa gcacttcccc accctcatcc    120
 tgggaagcca tcgagtggtc accaatgggg ttcctgggtt ccagtcgtgg ctctatttct    180
 caaagccctg tgaccgtggg cacgttgccg aacctctgtg ggctcttgcc ttcaccaaca    240
 cctatctctt ctacggtgcg taccgagtgg ggccggagag cagctccgtg tacagcatcc    300
 gcctggccta cctcctcagc ccgctggcct gcctgctcct ctgcttctgt gggactctgc    360
 ggcggatggt gaaggggctg ccgcagaaga ctctgctggg tcagggctat caggcgcctc    420
 tcagcgccaa ggtcttctcc tcatgggact tctgcatccg ggtgcaggaa gcagccacca    480
 tcaagaagca tgagatcagc aacgagttca aggtggagct ggaggagggc cgtcgcttcc    540
 agctgatgca gcagcagacc cgggcccaga cggcctgccg cctgctctcc tacctgcggg    600
 tcaacgtact catcgggctc ctggtggttg gggccatcag cgccatcttc tgggctacca    660
 agtactcaca ggacaacaag gaggagtccc tgtttctgct gctccagtac ctgccccctg    720
 gggtcatcgc cctggtcaac ttcctgggtc ccctgctgtt cacatttctg gtccagctgg    780
 agaactaccc tcccaacacg gaggtcaacc tcactctgat ctggtgcgtg gtgctgaagc    840
 tggccagctt ggggatgttc tccgtctccc tgggtcagac catactgtgc attggcagag    900
 acaagagcag ctgtgagtcc tacggctaca acgtttgtga ctatcagtgc tgggagaact    960
 ccgtggggga ggagctgtac aagctgagta tcttcaactt cctcctcacc gtggccttcg   1020
 ccttcctggt caccctgcct cggaggctgc tggtggaccg gttctcaggc cggttctggg   1080
 cctggctgga acgggaggag ttcctggtcc ccaagaatgt gctggacatc gtggcggggc   1140
 agacggtcac ctggatgggc ctcttctact gccccctgct gcccctgctg aatagcgtct   1200
 tcctcttcct caccttctac atcaagaagg tgacggctca tggctggggg gtatggggtt   1260
 cgtgcctctg ggtggatgcc ttgagctggg ctcgcctcct gctcctgctc ctgccccctt   1320
 ccctgggtgt cagccccctg gggtctgcat aactcgctga ctcctggttg ctattgcttg   1380
 cgcccccagt acacccttct gaaa                                          1404



      <210> 749
      <211> 618
      <212> DNA
      <213> Homo sapiens


      <400> 749
 cacggcgatg agaacagcga ggtgtggcgg agcctgttcg cccgcagtct ggcagaagag     60
 gctctgcgca cggacatcct gtgcaacctg cccagctaca aggccaagat acgtgctttt    120
 caacatgcct tcagcactaa tgactgctcc aggaatgtct acattaagaa gaatggcttt    180
 actttacatc gaaaccccat tgctcagagc actgatggtg caaggaccaa gattggtttc    240
 agtgagggcc gccatgcatg ggaagtgtgg tgggagggcc ctctgggcac tgtggcagtg    300
 attggaattg ccacaaaacg ggcccccatg cagtgccaag gttatgtggc attgctgggc    360
 agtgatgacc agagctgggg ctggaatctg gtggacaata atctactaca taatggagaa    420
 gtcaatggca gttttccaca gtgcaacaac gcaccaaaat atcagatagg agaaagaatt    480
 cgagtcatct tggacatgga agataagact ttagcttttg aacgtggata tgagttcctg    540
 ggggttgctt tttagaggac tttccaaagg tctgctttat aacccagcag tttctgctgt    600
 atatggcaac acagaagt                                                  618



      <210> 750
      <211> 2967
      <212> DNA
      <213> Homo sapiens


      <400> 750
 atgggcgagg acttcatgac taaaacacca aaagcaatgg caacaaaagc caaaattgac     60
 aaatggcatc taattaaact aaagagcttc tgcacagcaa aagaaactac catcagaatg    120
 aacaggcaac ctacagaatg ggagaaaatt tttgcaatct acccatctga caaagggcta    180
 atatccagaa tctgcaaaga acttaaacaa atttacaaga aaaaatcaaa caactccatc    240
 aataagtggg caaaggatat gaacagacac ttctcgaaag aagacattta tgcaaccaaa    300
 agacacatga aagaatgttc atcatcactg gccatcagag aaatgcaaat caaaaccacc    360
 atgagatact atctcacacc agttagaatg gcaatcatta aaaagtcagg aaacaacagg    420
 tgctggaaag gatatggaga aataggaaca cttttacact gttggtggga ctgtaaacta    480
 gttcaaccat tgtggaagac agtgtggcga ttcctcaagg atctagaact agaaatacca    540
 tttgatccag cgatcccatt actgggtata tacccaaagg attataaatc atgctgctat    600
 aaagacacat gcacacgttc aatcctgtat gcccagagct tcctgggcac cagtcatttg    660
 aatgggcagt tcctgtgttt aaccaggaag gtcgtgggag gatttcgaac ctgtcagaag    720
 caaagtgaag ggctccagac tctccggaca gatgggctga ggcactcctg ggattgtctt    780
 tatacggcca tggaatctga tagtggtggt catcgcaaag tttggaaacc cggctactgt    840
 gtggtccgat tcagacggga tgcgaaggcg ctgaaatccg tgcgagaggc tgcccccgct    900
 gccggggact cgcgtcagcg cggccggagc tacggtgccc gcgccctgga cgcaccagcc    960
 cgagagcacg cggagtggac caaatgcatt gttcagctgg gtcatctcct tgctacccag   1020
 catcccgcgg cgcccacatg tggagtcgtt tccagcgccc tggtcatgca ctcaacagat   1080
 gtctgtctag cccccactat gcaccaggca ctggactggg cagcaggaat ttggtttaca   1140
 ggaagattag gactcagaga gcataaatca ctggcccagg gtgactcagt ctgtccatgt   1200
 gaaagtgaac ttggtgattt ccaagtctat ggcttggtca gtacagaagg agtggtgtcc   1260
 tgctttggag agaagacccc gcagcatcct ggccctcctg cttcattgtc cctggccaac   1320
 aggtgccaca acgttgtgac agctgtagga gcctggccag ctcatgggag catccttgga   1380
 aatgttccag aagcccctgt gggagctgat gtgttggggg ctggaggatg tgactgggca   1440
 gacaaagagg ccctggcccc tgggcaaagg gcaaaggtgc acattcttct tgagagttct   1500
 ggacagtctg atccatccta tgctgtcctt cctgacagct gggcagccac ggagggtttc   1560
 ccaacttaca gatctcaggt ctcctctccc cgcatcccgg gtagttccat ctggttaggc   1620
 agtgggtctg gttggcctat acttggggaa ctcagggaat gtgaccagat gttctcctgc   1680
 atgttgccca ctggttgtgc ctccttccag gatccaggac gttatggtga ttatgacctc   1740
 cctatggatg aggatgagga catgaccaag acccggacct tcttcgcagc caagatcgtc   1800
 attggcattg cactggcagg catcatgctg gtctgcggca tcggtaactt tgtctttatc   1860
 gctgccctca cccgctataa gaagttgcgc aacctcacca atctgctcat tgccaacctg   1920
 gccatctccg acttcctggt ggccatcatc tgctgcccct tcgagatgga ctactacgtg   1980
 gtacggcagc tctcctggga gcatggccac gtgctctgtg cctccgtcaa ctacctgcgc   2040
 accgtctccc tctacgtctc caccaatgcc ttgctggcca ttgccattga caggttttct   2100
 tccaccatct atgacagctt cttgatctgt ccccaggtgg gtggctgtgt tcaacgggtg   2160
 ttgcttgtga cagttggggt cctcctcagc atcagtctcg acatgactgc aaatgggggg   2220
 tcctcgggat cctcctggaa tctcttcctc agcatctggc tcatgataag atatctcgcc   2280
 atcgttcacc ccttgaaacc acggatgaat tatcaaacgg cctccttcct gatcgccttg   2340
 gtctggatgg tgtccattct cattgccatc ccatcggctt actttgcaac agaaacggtc   2400
 ctctttattg tcaagagcca ggagaagatc ttctgtggcc agatctggcc tgtggatcag   2460
 cagctctact acaagtccta cttcctcttc atctttggtg tcgagttcgt gggccctgtg   2520
 gtcaccatga ccctgtgcta tgccaggatc tcccgggagc tctggttcaa ggcagtccct   2580
 gggttccaga cggagcagat tcgcaagcgg ctgcgctgcc gcaggaagac ggtcctggtg   2640
 ctcatgtgca ttctcacggc ctatgtgctg tgctgggcac ccttctacgg tttcaccatc   2700
 gttcgtgact tcttccccac tgtgttcgtg aaggaaaagc actacctcac tgccttctac   2760
 gtggtcgagt gcatcgccat gagcaacagc atgatcaaca ccgtgtgctt cgtgacggtc   2820
 aagaacaaca ccatgaagta cttcaagaag atgatgctgc tgcactggcg tccctcccag   2880
 cgggggagca agtccagtgc tgaccttgac ctcagaacca acggggtgcc caccacagaa   2940
 gaggtggact gtatcaggct gaagtga                                       2967



      <210> 751
      <211> 742
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(742)
      <223> n = a,t,c or g


      <400> 751
 gggccccagt ggctgctcat cctggtgctg gaagccctgt gntggngctt gacattcctc     60
 ctgccagtcc ctgggtgccc tactggttat cttggtcctg ggggcattgg agattttggc    120
 aagtatccaa attgcactgg aggagctgca ggctacatcg accgcctgct gctgggagac    180
 gatcaccttt accagcaccc atcttctgct gtactttacc acaccgaggt ggcctatgac    240
 cccgagggca tcctgggcac catcaactcc atcgtgatgg cctttttagg agttcaggca    300
 ggaaaaatac tattgtatta caaggctcgg accaaagaca tcctgattcg attcactgct    360
 tggtgttgta ttcttgggct catttctgtt gctctgacga aggtttctga aaatgaaggc    420
 tttattccag taaacaaaaa tctctggtcc ctttcgtatg tcactacgct cagttctttt    480
 gccttcttca tcctgctggt cctgtaccag ttgtggatgt gaaggggctg tggacaggaa    540
 ccccattctt ttatccagga atgaattcca ttctggtata cgtcggccac gaggtgtttg    600
 agaactactt cccctttcag tggaagctga aggacaacca gtcccacaag gagcacctga    660
 ctcagaacat cgtcgccact gccctctggg tgctcattgc ctacatcctc tatagaaaga    720
 agattttttg gaaaatctga tg                                             742



      <210> 752
      <211> 1729
      <212> DNA
      <213> Homo sapiens


      <400> 752
 cgctgcgcag ttttgttctg ctccagctgt tcgaaggtga tccaggttgg ccaggttcat     60
 ggcggcttga tgggaattat tcagagagct atggtcaagg cttgtcctca tgtctggttt    120
 gaacgctcag aaatgaagga tcgacacctg gttactaaga gactaaaaga acatattgct    180
 gataagaaga aactacccat actaattttt cctgaaggaa cttgcatcaa caatacttca    240
 gtcatgatgt ttaaaaaggg gagctttgaa attggaggaa ccatacatcc agttgcaatt    300
 aagtataacc ctcagttcgg tgatgcattt tggaacagta gtaaatacaa catggtgagc    360
 tacctgcttc gaatgatgac cagctgggcc atcgtctgtg acgtgtggta catgcccccc    420
 atgaccagag aggaaggaga agatgcagtc cagtttgcta acagggttaa gtctgctatt    480
 gctatacaag gaggcctgac tgaacttccc tgggatggag gactaaagag agcaaaggtg    540
 aaggacatct ttaaggaaga gcagcagaaa aattacagca agatgattgt gggcaatgga    600
 tctctcagct aagaggacgg atgacagcct ttagatctag aactagccct tagaaatgga    660
 atggcttttt ttgttttgtt ttgttttatt gttttgtttt tattattgtt aatcttttct    720
 acagaatgat tgtctctacc tctttatgcc agaggcagaa cctacaggtg ccctttttgg    780
 cttttgttgt tgttgtaaca ttagccccat ggattgtaag gtggtttact gagttaaaac    840
 agattctgct tttgtaaaat gatggcatca ctgtggactg aatgaaatat ttgtatagaa    900
 aaaagtgctt gaaaagtgtg tttggaactc atcgataggg taattctcca aaaatgccca    960
 aactctcttt ctgtaattag ccttgccact ttcttcagtc acttaaatgg tgagattaca   1020
 catcagtgca agatgaccat tatggttatg gtctactgca aggttgaaag gaaaaatgga   1080
 ggattgtatt taggaaaagg gacaactttg tggccacctg ctctgaaagt caaaaggaaa   1140
 tgtaaattag tgtcattagt gtgttggaag agaaatacta ttcagtaagc ttcgccaaag   1200
 aaaagtgagt caaagttaat gtgtgtgtgc atttatatgt aggcagctcg tagaccacat   1260
 tttagccagc aactggtaac aaagagctta gttttccttg tttgaatgct gtagatctgt   1320
 acctagtacc cctcccatct actgatttgt ttgtttttgt aaccaaacac attttcagat   1380
 agaaggagcc ttaaaaaaaa aaaaaatcac attgagtaac ttcagtataa atgaatgaaa   1440
 ggggggggag ctacccctca tcctccaccc ctttgggctt tttattcccg aattttccca   1500
 gtcttttaaa caaaaaaagg actgatataa ttattttttg gaaactgagc cttaattttt   1560
 tttagagggg gaaataagtt ttccccaact cacacagcat aagcaatgtt tgacagcaat   1620
 ataatgccgt tgtaaactac tgagagtatt gtatctgttc tggtaaccat gtacagaatg   1680
 tgaaactgtc ttatgaatat aaataaattc tatatttcta aaaaaaaaa               1729



      <210> 753
      <211> 1333
      <212> DNA
      <213> Homo sapiens


      <400> 753
 aagcttggca cgagggtctt gtcagcagcc cggccattgg agcatatctt tctgccagtt     60
 acggagacag cctcgttgtg ctggtggcca cagtggtggc tcttctggac atctgcttca    120
 tcttagtggc tgttccagaa tctctgcctg agaaaatgag accggtttcc tggggagctc    180
 agatttcttg gaaacaagca gacccttttg cgtcgttgaa gaaagttgga aaagattcta    240
 ctgtcttact aaatctgcat caccgtgtgt ctttcatacc ttcctgaagc tgggacagta    300
 ttcaagtttt ttttctctat ctcagggcag gtcatagggt ttgggatctg ttaaaattgc    360
 agcattcata gctatggtag gaattctgtc tattgtggct cagacggcct ttcttagcat    420
 cttgatgaga tcattaggaa ataagaatac tgtcctcctt ggcttgggct tccagatgct    480
 ccagttagcc tggtacggtt ttggatcaca ggcctggatg atgtgggcag cagggaccgt    540
 ggctgccatg tccagcatca cgtttccggc aatcagtgcc ctcgtctctc ggaatgcaga    600
 gtcagatcag caaggagttg cccaggggat cataactgga ataagaggac tatgcaatgg    660
 cctggggcca gcactgtatg gcttcatatt ctacatgttc catgtggaac tgactgagtt    720
 gggcccgaaa ttgaattcta acaacgttcc cctgcaggga gctgtcatcc caggcccgcc    780
 gtttttattt ggggcatgta tagtccttat gtcttttctg gctgccttat tcattcctga    840
 atacagtaaa gccagtggag ttcaaaaaca cagtaacagc agcagcggca gcctgaccaa    900
 caccccagaa cggggcagtg atgaggacat tgagccacta ctgcaagaca gcagcatctg    960
 ggagctctct tcatttgagg agcctgggaa tcagtgcact gagctgtaaa ctcggcagaa   1020
 agtgggattc tgcatacgcc atctctgaga gccatggagg gagccacacc cctggtgact   1080
 tcatggtgct ggatgggaga cgctagcggc atccttcagg gccaagtttg ataaatacca   1140
 ccgccatcat tctgctcatc ctcctcctgt tttttttttt ctcttacatt cttttttttt   1200
 tcccggttaa tccttaaaac cagaaaaaaa ttggaaaaac ttctttgcaa aaagggggca   1260
 actcccaggg ggaacctcaa ataaaaaaag cattcttttg tgaaaaaagg agggcttcct   1320
 tgaaaggaca aaa                                                      1333



      <210> 754
      <211> 388
      <212> DNA
      <213> Homo sapiens


      <400> 754
 ggcagcgggc gacgcgccct tgcgcagcct ggagcaagcc aaccgcaccc gctttccctt     60
 cttctccgac gtcaagggcg accaccggct ggtgctggcc gcggtggaaa caaccgtgct    120
 ggtgctcatc tttgcagtgt cgctgctggg caacgtgtgc gccctggtgc tggtggcgcg    180
 ccgacgacgc cgcggcgcga ctgcctgcct ggtactcaac ctcttctgcg cggacctgct    240
 cttcatcagc gctatccctc tggtgctggc cgtgcgctgg actgaggcct ggctgctggg    300
 ccccgttgcc tgccacctgc tcttctacgt gatgaccctg agcggcagcg tcaccatcct    360
 cacgctggcc gcggtcagcc tggagcgc                                       388



      <210> 755
      <211> 3144
      <212> DNA
      <213> Homo sapiens


      <400> 755
 tttcttttct ttgaatgaca gaactacagc ataatgcgtg gcttcaacct gctcctcttc     60
 tggggatgtt gtgttatgca cagctgggaa gggcacataa gacccacacg gaaaccaaac    120
 acaaagggta ataactgtag agacagtacc ttgtgcccag cttatgccac ctgcaccaat    180
 acagtggaca gttactattg cacttgcaaa caaggcttcc tgtccagcaa tgggcaaaat    240
 cacttcaagg atccaggagt gcgatgcaaa gatattgatg aatgttctca aagcccccag    300
 ccctgtggtc ctaactcatc ctgcaaaaac ctgtcaggga ggtacaagtg cagctgttta    360
 gatggtttct cttctcccac tggaaatgac tgggtcccag gaaagccggg caatttctcc    420
 tgtactgata tcaatgagtg cctcaccagc agggtctgcc ctgagcattc tgactgtgtc    480
 aactccatgg gaagctacag ttgcagctgt caagttggat tcatctctag aaactccacc    540
 tgtgaagacg tggatgaatg tgcagatcca agagcttgcc cagagcatgc aacttgtaat    600
 aacactgttg gaaactactc ttgtttctgc aacccaggat ttgaatccag cagtggccac    660
 ttgagtttcc agggtctcaa agcatcgtgt gaagatattg atgaatgcac tgaaatgtgc    720
 cccatcaatt caacatgcac caacactcct gggagctact tttgcacctg ccaccctggc    780
 tttgcaccaa gcaatggaca gttgaatttc acagaccaag gagtggaatg tagagatatt    840
 gatgagtgcc gccaagatcc atcaacctgt ggtcctaatt ctatctgcac caatgccctg    900
 ggctcctaca gctgtggctg cattgtaggc tttcatccca atccagaagg ctcccagaaa    960
 gatggcaact tcagctgcca aagggttctc ttcaaatgta aggaagatgt gatacccgat   1020
 aataagcaga tccagcaatg ccaacaggga accgcagtga aacctgcata tgtctccttt   1080
 tgtgcacaaa taaataacat cttcagcgtt ctggacaaag tgtgtgaaaa taaaacgacc   1140
 gtagtttctc tgaagaatac aactgagagc tttgtccctg tgcttaaaca aatatccacg   1200
 tggactaaat tcaccaagga agagacgtcc tccctggcca cagtcttcct ggagagtgtg   1260
 gaaagcatga cactggcatc tttttggaaa ccctcagcaa atgtcactcc ggctgttcgg   1320
 acggaatact tagacattga gagcaaagtt atcaacaaag aatgcagtga agagaatgtg   1380
 acgttggact tggtagccaa gggggataag atgaagatcg ggtgttccac aattgaggaa   1440
 tctgaatcca cagagaccac tggtgtggct tttgtctcct ttgtgggcat ggaatcggtt   1500
 ttaaatgagc gcttcttcca agaccaccag gctcccttga ccacctctga gatcaagctg   1560
 aagatgaatt ctcgagtcgt tgggggcata atgactggag agaagaaaga cggcttctca   1620
 gatccaatca tctacactct ggagaacgtt cagccaaagc agaagtttga gaggcccatc   1680
 tgtgtttcct ggagcactga tgtgaagggt ggaagatgga catcctttgg ctgtgtgatc   1740
 ctggaagctt ctgagacata taccatctgc agctgtaatc agatggcaaa tcttgccgtt   1800
 atcatggcgt ctggggagct cacgatggac ttttccttgt acatcattag ccatgtaggc   1860
 attatcatct ccttggtgtg cctcgtcttg gccatcgcca cctttctgct gtgtcgctcc   1920
 atccgaaatc acaacaccta cctccacctg cacctctgcg tgtgtctcct cttggcgaag   1980
 actctcttcc tcgccggtat acacaagact gacaacaaga tgggctgcgc catcatcgcg   2040
 ggcttcctgc actacctttt ccttgcctgc ttcttctgga tgctggtgga ggctgtgata   2100
 ctgttcttga tggtcagaaa cctgaaggtg gtgaattact tcagctctcg caacatcaag   2160
 atgctgcaca tctgtgcctt tggttatggg ctgccgatgc tggtggtggt gatctctgcc   2220
 agtgtgcagc cacagggcta tggaatgcat aatcgctgct ggctgaatac agagacaggg   2280
 ttcatctgga gtttcttggg gccagtttgc acagttatag tgatcaactc ccttctcctg   2340
 acctggacct tgtggatcct gaggcagagg ctttccagtg ttaatgccga agtctcaacg   2400
 ctaaaagaca ccaggttact gaccttcaag gcctttgccc agctcttcat cctgggctgc   2460
 tcctgggtgc tgggcatttt tcagattgga cctgtggcag gtgtcatggc ttacctgttt   2520
 caccatcatc aacagcctgc agggggcctt catcttcctc atccactgtc tgctcaacgg   2580
 ccaggtacga gaagaataca agaggtggat cactgggaag acgaagccca gctcccagtc   2640
 ccagacctca aggatcttgc tgtcctccat gccatccgct tccaagacgg gttaaagtcc   2700
 tttcttgctt tcaaatatgc tatggagccc acagttggag ggacaagtag ttttccctgc   2760
 agggagccct acccctgaaa atctccttcc tcagcttaaa catgggaaat gagggatccc   2820
 cacccagccc ccagaaccct ctgggggaag gaatgttggg gggccgtctt cctgtgggtt   2880
 gtattgcact gatggaggaa atcaggtgtt tctgctccaa acggaccatt ttatcttcgt   2940
 gctctgcaac ttcttcaatt ccagagtttc tgagaacaga cccaaattca atggcatgac   3000
 caagaacacc tggctaccat tttgttttct cctgcccttg ttggtgcatg gttctaagcg   3060
 tgcccctcca gcgcctatca tacgcctgac acagagaacc tctcaataaa tgatttgtcg   3120
 cctgtctgac tgatttaccc taaa                                          3144



      <210> 756
      <211> 1635
      <212> DNA
      <213> Homo sapiens


      <400> 756
 ttctgccttc tgggacgagg cgctcgtcac catcctagcc gtgtgcatct atggcatcgc     60
 gcctgtgggc ttctcgcagc atgagacggt ggactcggtg ctgcggaacc gcggggtcta    120
 cgagaacgtc aagtacgtgc agcaggagaa cttctggatc gggcccagct cggaggccct    180
 catccacctg ggcgccaagt tttcgccctg catgcgccag gacccgcagg tgcacagctt    240
 cattcgctcg gcgcgcgagc gcgagaagca ctccgcctgc tgcgtgcgca acgacaggtc    300
 gggctgtgtg cagacctcgg aggaggagtg ctcgtccacg ctggcagtgt gggtgaagtg    360
 gcccatccat cccagcgccc cagagcttgc gggccacaag agacagtttg gctctgtctg    420
 ccaccaggat cccagggtgt gtgatgagcc ctcctccgaa gaccctcatg agtggccaga    480
 agacatcacc aagtggccga tctgcaccaa aaacagcgct gggaaccaca ccaaccatcc    540
 ccacatggac tgtgtcatca caggacggcc ctgctgcatt ggcaccaagg gcaggtgtga    600
 gatcacctcc cgggagtact gtgacttcat gaggggctac ttccatgagg aggccacgct    660
 ctgctctcag gtgcactgca tggatgatgt gtgtgggctc ctgccttttc tcaaccccga    720
 ggtgcctgac cagttctacc gcctgtggct atccctcttc ctgcacgccg ggatcttgca    780
 ctgcctggtg tccatctgct tccagatgac tgtcctgcgg gacctggaga agctggcagg    840
 ctggcaccgc atagccatca tctacctgct gagtggtgtc accggcaacc tggccagtgc    900
 catcttcctg ccataccgag cagaggtggg tcctgctggc tcccagttcg gcatcctggc    960
 ctgcctcttc gtggagctct tccagagctg gcagatcctg gcgcggccct ggcgtgcctt   1020
 cttcaagctg ctggctgtgg tgctcttcct cttcaccttt gggctgctgc cgtggattga   1080
 caactttgcc cacatctcgg ggttcatcag tggcctcttc ctctccttcg ccttcttgcc   1140
 ctacatcagc tttggcaagt tcgacctgta ccggaaacgc tgccagatca tcatctttca   1200
 ggtggtcttc ctgggcctcc tggctggcct ggtggtcctc ttctacgtct atcctgtccg   1260
 ctgtgagtgg tgtgagttcc tcacctgcat ccccttcact gacaagttct gtgagaagta   1320
 cgaactggac gctcagctcc actgagctgg ctgcgggctc cagcggccgt gtgctccagc   1380
 aggccagagc cagacacgac ctccctgagc ctcacaggct tacaggagtc acctgctcca   1440
 tgtggggact ggcctgtttc ctgaacacag acctctttct tgtgccttgt tcacttctgt   1500
 tgaacccctc gtactgccgg gcatttatta tactacttcc tgtcataacc ttctaacttg   1560
 tttcttgacg accacctcat gtggccaata aatggactgg gagcgtttta gctgccatta   1620
 acttgaaaaa aaaaa                                                    1635



      <210> 757
      <211> 1635
      <212> DNA
      <213> Homo sapiens


      <400> 757
 ttctgccttc tgggacgagg cgctcgtcac catcctagcc gtgtgcatct atggcatcgc     60
 gcctgtgggc ttctcgcagc atgagacggt ggactcggtg ctgcggaacc gcggggtcta    120
 cgagaacgtc aagtacgtgc agcaggagaa cttctggatc gggcccagct cggaggccct    180
 catccacctg ggcgccaagt tttcgccctg catgcgccag gacccgcagg tgcacagctt    240
 cattcgctcg gcgcgcgagc gcgagaagca ctccgcctgc tgcgtgcgca acgacaggtc    300
 gggctgtgtg cagacctcgg aggaggagtg ctcgtccacg ctggcagtgt gggtgaagtg    360
 gcccatccat cccagcgccc cagagcttgc gggccacaag agacagtttg gctctgtctg    420
 ccaccaggat cccagggtgt gtgatgagcc ctcctccgaa gaccctcatg agtggccaga    480
 agacatcacc aagtggccga tctgcaccaa aaacagcgct gggaaccaca ccaaccatcc    540
 ccacatggac tgtgtcatca caggacggcc ctgctgcatt ggcaccaagg gcaggtgtga    600
 gatcacctcc cgggagtact gtgacttcat gaggggctac ttccatgagg aggccacgct    660
 ctgctctcag gtgcactgca tggatgatgt gtgtgggctc ctgccttttc tcaaccccga    720
 ggtgcctgac cagttctacc gcctgtggct atccctcttc ctgcacgccg ggatcttgca    780
 ctgcctggtg tccatctgct tccagatgac tgtcctgcgg gacctggaga agctggcagg    840
 ctggcaccgc atagccatca tctacctgct gagtggtgtc accggcaacc tggccagtgc    900
 catcttcctg ccataccgag cagaggtggg tcctgctggc tcccagttcg gcatcctggc    960
 ctgcctcttc gtggagctct tccagagctg gcagatcctg gcgcggccct ggcgtgcctt   1020
 cttcaagctg ctggctgtgg tgctcttcct cttcaccttt gggctgctgc cgtggattga   1080
 caactttgcc cacatctcgg ggttcatcag tggcctcttc ctctccttcg ccttcttgcc   1140
 ctacatcagc tttggcaagt tcgacctgta ccggaaacgc tgccagatca tcatctttca   1200
 ggtggtcttc ctgggcctcc tggctggcct ggtggtcctc ttctacgtct atcctgtccg   1260
 ctgtgagtgg tgtgagttcc tcacctgcat ccccttcact gacaagttct gtgagaagta   1320
 cgaactggac gctcagctcc actgagctgg ctgcgggctc cagcggccgt gtgctccagc   1380
 aggccagagc cagacacgac ctccctgagc ctcacaggct tacaggagtc acctgctcca   1440
 tgtggggact ggcctgtttc ctgaacacag acctctttct tgtgccttgt tcacttctgt   1500
 tgaacccctc gtactgccgg gcatttatta tactacttcc tgtcataacc ttctaacttg   1560
 tttcttgacg accacctcat gtggccaata aatggactgg gagcgtttta gctgccatta   1620
 acttgaaaaa aaaaa                                                    1635



      <210> 758
      <211> 412
      <212> DNA
      <213> Homo sapiens


      <400> 758
 acacatctgt gagcctttcg gtgagcaggt gaggcaattc ctcttcagca acacactcct     60
 ctggaatctt cagcatgatg aagaatgttt tgtttgatga taattcaagt atttcatttt    120
 catcttcatc aacataagtt actgcagcaa gacataagcc tatgatgatc actgtaatga    180
 cacctaggaa aatggaggtg atgatcatcc acagtttgca tcttccaacc acattcttat    240
 tacaggagct ccaggggctt tccttgttag cctcggccgg ggggacctcc tcgtccaaag    300
 aagggaagac ctcgtcggca ccattgagag gcgtgttctc ttctggctgc cgctcgagca    360
 ccgagagctc cagctcgtct actggctgtg agggttgggc caggtccatg tg            412



      <210> 759
      <211> 540
      <212> DNA
      <213> Homo sapiens


      <400> 759
 tttcgtctgg tggacctgca tcaggagcaa gattcaaacc ttaatggctt taagcctctc     60
 aaggtttgag gtcatgacca cagcacaacc tagcctatgc cagctgacag gggcagaggg    120
 cagcagtagc agtgggatgc tttcctggag agcaaacctc ctctcagcag agttaggacg    180
 gcagctttca cctctgcatt cctcaggctg taaatgatgg ggttcagcga gggcgtcaca    240
 accccgtaga acaatgcgac agtcttatcc acgttgggat ccttggcctt gggtttgaag    300
 tacatgaagg agattgtccc ataaaaaacc accaccactg tgcggtgggc tgagcaggtg    360
 gagaaggctt tgcaccggcc tgcagcagag ggtaccctaa ggatggcaga caggatgaaa    420
 aggtaagaca ggcagatgag caagaggggg gccagtgtca ggacggctgt ggccaccatt    480
 aatgccagcg cattgaggga gatgtcccca caggccagtt ttagcactgc caagatctca    540



      <210> 760
      <211> 1054
      <212> DNA
      <213> Homo sapiens


      <400> 760
 gtgcggtgga attccctggt gctctgggat ggtccttctc ttaggccctg aggggtgacc     60
 tcggggccat tcccaggatg ggccttcctc actggtaccc cacccctctc ccgccaggca    120
 tggccgcctt tgccaccgcc cacctcctct acgtctgggc cttcggcttc tctcccctgc    180
 agcccggcct gctgctgctc atcatcctgg cccctggccc ctacctcagc cttgtgctcc    240
 agcacctcga gccggatatg gtcctgccgg tggcagccta tgggctgatc ctgatggcca    300
 tgctgtggcg cggcctggcc cagggcggga gtgccggctg gggcgcgctg ctcttcacgc    360
 tctctgatgg cgtgctggcc tgggacacct tcgcccagcc cctgccccat gcccgcctgg    420
 tgatcatgac cacctactat gctgcccagc tcctcatcac actgtcagcc ctcaggagcc    480
 cggtgcccaa gactgactga ctagggagct tgaagggccg gtgttcaggc cctctcctcc    540
 tgcaaggacc tgggcctccc agcccagccc agcctgagaa ataccctcag cagcgaagct    600
 tcctgacgcc tgtctgcagg cgccgctgcc gccgtcgctt ctggctgaag acgtttgagg    660
 acgatttgcg gaattccaag tccactactg ggttccagct gccttccccc ggttctgact    720
 ccagatccct ggctcctcag ccaggcccac atggagccct cccagccacc agcctgcctc    780
 catgttcact gtcggcccca cagcctgccc gccccctgct gctgctctga atccgttttc    840
 cctgtgggtg tggaaccgta gatgttgctg ttaccgtagg agaggcctcg gggagggtca    900
 tcattgtgat aaaccatcgc ggttaatgac agcagaaggt tctttgtcgc tccccatgga    960
 ccaggcctgg tgcccagtgg gaccctccat ggccctctgg tggggggccc cggggggata   1020
 aagtgaggat tgtgcagaac tgaaaaaaaa aaaa                               1054



      <210> 761
      <211> 4912
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(4912)
      <223> n = a,t,c or g


      <400> 761
 cagagaacgt ttgtctgcct gatgagagcc acttgggtta agaaactacc tgtgaatagt     60
 catcatttct gtccttcatt ggggaatact tttagaggcc agtttccaaa aattctgctt    120
 aaaaaagaat tctggttttg tcttactctt ccagatgaga tatcacagag gcttgggcct    180
 agattgtcat cagcatactg ctatactatt cgtttgttct tattaagcct tattgtgtgt    240
 aatgctgtta ctttttcaga gtgttgcgga gataggaaca tgggagagaa acaatctggg    300
 taacatgaaa gtgatgctgg ttgctaaggg aaggcaactt gattctgtgg gaagggctgt    360
 agctgatcca tccgttgtct agatttgagt atgagcacag tggaagagga ttctgacaca    420
 gtaacagtag aaactgtgaa ctctgtgact ttgactcagg acacagaagg gaatctcatt    480
 cttcactgcc ctcagaatga agcggatgaa atagactcag aagatagtat tgaacctcca    540
 cataaaaggc tttgtttgtc ctctgaggat gatcagagta ttgatgattc tactccttgc    600
 atatcagttg ttgcacttcc actttcagaa aatgatcaga gctttgaagt gaccatgact    660
 gcgaccacag aagtagcaga tgatgaggtt actgagggga ctgtgacaca gatacagatt    720
 ttgcagaatg agcaactaga tgaaatatct cccttgggta acgaggaagt ttcagcagtt    780
 agccaagcat ggtttacaac taaagaagat aaggattctc tgactaataa aggacataaa    840
 tggaagcagg ggatgtggtc caaggaagaa attgatattt tgatgaacaa tattgaacgc    900
 tatcttaagg cacgcggaat aaaagatgct acagaaatca tctttgagat gtcaaaagac    960
 gaaagaaaag atttctacag gactatagca tggggtctga accggccttt gtttgcagtt   1020
 tatagaagag tgcttcgcat gtatgatgac agaaaccatg tgggaaaata tacacctgaa   1080
 gaaattgaga agctcaagga gctccggata aagcatggca atgactgggc aacaataggg   1140
 gcggcgctag gaagaagtgc atcttctgtc aaagatcggt gccgactgat gaaggatact   1200
 tgcaacacag ggaagtggac agaagaagaa gaaaagagac ttgcagaagt ggttcatgag   1260
 ttgacaagca ctgagcccag gtgacatagt cacacagggt gtgtcttggg cagctgtggc   1320
 tgaacgagtc ggtacccgct cagaaaagca atgtcgttct aaatggctca actacctgaa   1380
 ttggaaacag agtgggggta ctgaatggac caaggaagat gaaatcaatc tcatcctcag   1440
 gatagcagaa cttgatgtag ctgatgaaaa tgacattaac tgggatctgt tagctgaggg   1500
 atggagtagt gtccgttcac cacaatggct acgaagtaaa tggtggacca tcaaaaggca   1560
 aattgcaaac cataaggatg tttcgttccc tgtcttaata aaaggtctta aacagttaca   1620
 tgagaaccaa aaaaacaacc caacgctttt ggagaataaa tcaggatctg gagttccaaa   1680
 cagtaatacc aattccagtg tgcagcatgt tcagataaga gttgcccgct tggaagataa   1740
 tacagccatc tcttctagcc ccatggcagc attgcagatt ccagtccaga tcacccatgt   1800
 ttcttcagca gactctcctg ctaccgttga ctcagaaaca ataacactaa acagtggaac   1860
 actacagaca tttgagattc ttccctcttt ccatctacag cccactggca ctccaggcac   1920
 ctacctactt caaacaagct caagccaagg ccttccccta actctgactg ctagtcccac   1980
 agtaaccctg acagctgctg ctccttgcnt tctcctgaac agattattgt tcatgcttta   2040
 tccccagaac atttgttgaa cacaagtgat aatgttacag gtgcagtgtc acacaccaag   2100
 agtcatcatt cagactgttg ccacagagga catcacttct tccatatccc aaggcaggaa   2160
 ctgaccgtcg atagtgatat tcagttcatt ctggattttc ctgagcctcc agacgcccta   2220
 gaaggcaaac actttcccag atgaaattca tcaccctaag atgactgtgg agccatcatt   2280
 taatgatgct catgtatcca aattcagtga ccaaaatagc acagaactga tgaatagtgt   2340
 tatggtcaga acagaaaaag aaatctctga caccgacctt aaacaagagg aatcaccctc   2400
 tgatttagcc agtgcttatg ttactgaggg tttagagtct cccactatag aagaacaagt   2460
 tgatcaaaca attgatgatg aaacaatact tatcgttcct tcaccacatg gctttatcca   2520
 ggcatctgat gttatagata ctgaatctgt cttgcctttg acaacactaa cagatcccat   2580
 actccaacat catcaggaag aatcaaatat cattggatca tccttgggca gtcctgtttc   2640
 agaagattca aaggatgtcg aagatttggt aaactgtcat tagaataatt cttagaaata   2700
 ggcagttcaa gcaaagaagg cacactgtta attacaacct cttcaaagaa ataggagcaa   2760
 cccccaagag gcttaattta ccaatttaaa tagccacagt ccttaagcca cacacattgt   2820
 tgctgctatg actttttacc tcctttaaac acatcatctg aggttgagtt ttatgacagt   2880
 atgtagttga gtggaggctg ggagttttaa gcataaatcc ctgtttagtg ttacatggga   2940
 ataaggaatt tcattcactt cagccactaa gaaaagttta gaatcacgaa agcttaactg   3000
 ctgtggttta aagtacagtt tctctaaaga tcagacatgg cactgtctcc tctcaagcct   3060
 ggttgtagtt cagatgagtc ttttcaacat ggtcttcaac atggtctaga gcttaccagt   3120
 gatcttctga tcttcaagaa gactaagttt gagacttgac cagcatacaa gtatagagac   3180
 ctaggaggtg gtcttgtggt ggtacatttg gttaacccat tgctggcagt gggagctgat   3240
 ttaggcaggg taaacaggaa agcattaaaa gttaaaattc actacaggtt ttttgttact   3300
 tttaaaggga atatggataa gcatagtaac aaaacccacc agaatctaag cagttttcac   3360
 cccctcagaa accactgtca ttagtttaca aagttagcac tttgaagtaa aactaaatga   3420
 ggaaggaagt aatgttacct atccttgata ccatgaccat ttattagatg ttttgctata   3480
 taaattaccg agagaatagt ttgtcatcca cttagtgtgt tagctggtgg ggtacaatat   3540
 aacctctcat ctcaggctat tttaaaaaaa caatatttgc ttctataaca aaaggaaaca   3600
 aatctaagaa tcattcctgt actacagaag ggttaaggca aaggtagcct tttgggcttt   3660
 ttaatgaata tgacccctat agaaaagtca agaaaaaaaa acccttgtat aaattatttt   3720
 atttattatt gtaattagat cttcacaaag ttgtcttttc actgtgtttt gtcaacgtga   3780
 aattaaattg tagttataag caaaagttgg ttgcctaggg aacaattgta tattcagttt   3840
 aacagaaata aaagaatatt tgtcttaaga tgcaagattt gtttttacat agccttttgc   3900
 catacaatta taaaaatttc atttcaaaag tgaaattttt ttgtgctgtt ttagctttaa   3960
 gggttggaat gtttaggtgc aacatcagct ccttaaagaa aaagcaaagt gatctaggat   4020
 atgtctccct tgcaagaggg aattaacatt tacaattaac atgaaaatca tgtatcagac   4080
 ttctgcagga gattcttcag cataccttat ccaaaaatta ctcactgtcc taatgtatca   4140
 ttttgaagag tcctggtaag tacttctcct tggcagcctc accttcccac atcatggaag   4200
 tacaggtttg cacatataca caacatgatg atagaaaata tgatatagta aattagcttt   4260
 ctaaatttcg gttctaagtc tccttgtcga taccagtaga taagtatgca ggcagtaata   4320
 ctactcaaag agatgcagac agcaaagaat atattcaacg gttttggagg tagttgaggg   4380
 aaaacaaaag cacttatcag cgttactaga atcaataagg atgttaagct gccaacaact   4440
 aaattgatga ttcgatcctt ggcggacgtc tccccaaaca gaggtctgtt gtccaggcca   4500
 ctggtgccgt aggtcctggt agcaaagtcc tccattttgg ggtttcttca ctttccccaa   4560
 gccacttaaa agcaagacag catgacctcc cgaggtctca ggtccacgac tgcaagcctc   4620
 ctcctcacgg ctcccgcata gccgaacccg agtggtcggg gaagcgctgg cgccagggat   4680
 gggtgggggc tcacacgcgg ggaacgcgac tgctccgccc cggccccgcg cacctcctca   4740
 tcttgagcag ctcggcatcc cctaggcgct cgcacgctgg ggggccctgg ccgcgccggg   4800
 gagagtgggc cctgggtcca cacccccgcc gggatccggt gccgaggccc aggaacgcgg   4860
 gccagatgcg tgggagagga atcgagcggt cccgtcgcag cgctgcggat ca           4912



      <210> 762
      <211> 1343
      <212> DNA
      <213> Homo sapiens


      <400> 762
 tttttttttt ttgagacaca gtttcactcg ttgcccaggc tggagtgcag tggcgcaatc     60
 tcggctcact gcaacttctg cctcctaggt tcaagcagtt ctcctgcctc agcctcccaa    120
 gtagttggga ttacgggcat gcaccaccat gcctggataa ttttttctta tttttagtag    180
 agacaggatt tcatcatgtt ggccacgctg gtttcgaact cctgaccaca tgtggtccac    240
 ccaccttggc ctcaattatg tgcattttgg tatatttact tgtatttcaa catcttgtga    300
 gtttgaaaaa cctgaaaggc cagaatgctt ccttttattt ctcaccattt gggcagcacc    360
 taagtggttt tgtaaaatgc agcatctggt gctgtgggtc tctctcaggc cttgagggac    420
 acttccttcc tccccactcg cctcctctcc actagacttt ggttcctaga gggcgtgggg    480
 ccgggtctga ggttcttgcc tgccttccct cccattggtc tttggttgct catccctcta    540
 actgcacccc ttcttggtcc ttcctccaca gacttcagat aatagataag tcattagcaa    600
 accagaccga atctttaggg tgaagagctc cccaaagcca tctggtgagg tcattgtggg    660
 gaccagggac tgattatttg tcacctggat cacaaagatg ggactgtctg ctcaggctgg    720
 tggtgacagg atcctgaccc gtggtcctct cccgctccct ctgctccacc aggacacatg    780
 tataggacac tgtgctgtgt gcagtggaga aatctccctg ggccagggga aagttcagac    840
 agtgcctcta gattgtgttt tgcctcctcc aatgtagagt tgacatctgg accccagagc    900
 ccagcagggc tttctgtcag acatgctagg gtggtagaaa tgggccctcc aggtccccct    960
 gcagtgcact gggcagagac ctccggaaag ccggcagcgg gagcgcttcc tgggcagctt   1020
 cccccagcac agtgttccca aaccagtcca tccggaaaac agtctgtaca gcaaatgctg   1080
 tgtgagatct taggcttttc actttttttt gttttgtttt gtttttgaaa gaaagaaaaa   1140
 aatacaatta ccaagcctct tttgtaaatg ggtttccttt ctatgtataa aatcgtggtg   1200
 gtcccttgtt tttacatgtt catgctgtgt aattttgaga tgttactgag atatgttctg   1260
 aacataatgt gcattttttt ctgtacagat gaaatgggag aatttaataa agagtttgca   1320
 ggtttttact tgttaaaaaa aaa                                           1343



      <210> 763
      <211> 4718
      <212> DNA
      <213> Homo sapiens


      <400> 763
 gatcaccatc accgagacca cctcacacag tactcccagc tacactacct caatcaccac     60
 caccgagacc ccctcacaca gtactcccag ctacactacc tcaatcacca ccaccgagac    120
 cccatcacac agtactccca gcttcacttc ttcaatcacc accaccgaga ccacatccca    180
 cagtactccc agcttcactt cttcaatcag gaccaccgag accacatcct acagtactcc    240
 cagcttcact tcttcaaata ccatcactga gaccacctca cacagtactc ccagctacat    300
 tacctcaatc accaccaccg agaccccctc aagcagtact cccagcttca gttcttcgat    360
 caccaccact gagaccacat cccacagtac tcccggcttc acttcttcaa tcaccaccac    420
 tgagactaca tcccacagta ctcccagctt cacttcttcg atcaccacca ctgagaccac    480
 ctcacatgat actcccagct tcacttcttc aatcaccacc agtgagaccc cctcacacag    540
 tactcccagc tccacttctt taatcaccac caccaagacc acctcacaca gtactcccag    600
 cttcacttct tcgatcacca ccaccgagac cacctcacac agtgctcgca gcttcacttc    660
 ttcgatcacc accaccgaga ccacctcaca caatactcgg agcttcactt cttcgatcac    720
 caccaccgag accaactctc acagtactac cagcttcact tcttcgatca ccaccaccga    780
 gaccacctca cacagtactc ccagcttcag ttcttcaatc accaccactg agaccccctt    840
 acacagtact cctggcctac cttcgtgggt caccaccacc aagaccacct cacacattac    900
 tcctggcctc acttcttcaa tcaccaccac tgagactacc tcacacagta ctcccggctt    960
 cacttcttca atcaccacca ctgagaccac ctcagagagt actcccagcc tcagttcttc   1020
 aaccatctac tccacagtca gcacatccac aactgccatc acctcacatt ttactacctc   1080
 agagactgcg gtgactccca cacctgtaac cccatcttct ctgagtacag acatcccgac   1140
 cacaagccta cgaactctca ccccttcgtc tgtgggcacc agcacttcat tgactacaac   1200
 cacagacttt ccctctatac ccactgatat cagtacctta ccaactcgaa cacacatcat   1260
 ttcatcttct ccctccatcc aaagtacaga aacctcatcc cttgtgggca ccacctctcc   1320
 caccatgtcc actgtgagaa tgaccctcag aattactgag aacaccccaa tcagttcctt   1380
 tagcacaagt attgttgtta tacctgaaac cccaacacag acccctcctg tactgacgtc   1440
 agccactggg acccaaacat ctcctgcacc tactactgtc acctttggaa gtacggattc   1500
 ctccacgtcc actcttcata ctcttactcc atcaacagcc ttgagcacga tcgtgtcaac   1560
 atcacaggtt cctattccta gcacacattc ctccaccctt caaacaactc cttctactcc   1620
 ctcattgcaa acttcactca catctacaag tgagttcact acagaatctt tcactagggg   1680
 aagtacgtct acaaatgcaa tcttgacttc ttttagtacc atcatctggt cctcaacacc   1740
 cactattatc atgtcctctt ctccatcttc tgccagcata actccagtgt tctccactac   1800
 cattcattct gttccttctt caccatacat tttcagtaca gaaaatgtgg gctccgcttc   1860
 tatcacaggc tttcctagtc tctcttcctc tgcaactacc agcacttctt caaccagctc   1920
 ctctctgacc acagctctca ctgaaataac ccccttttct tatatttccc ttccctccac   1980
 cacaccctgt ccaggaacta taacaattac catagtccct gcctctccca ctgatccatg   2040
 tgttgaaatg gatcccagca ctgaagctac ttctcctccc accaccccat taacagtctt   2100
 tccctttact accgaaatgg tcacctgtcc tacctccatc agtatccaaa ctactcttac   2160
 tacatatatg gacacttctt ccatgatgcc agaaagtgag tccagcatct cacccaatgc   2220
 ttccagttcc actggcactg ggactgtacc cacaaacaca gttttcacaa gtactcgact   2280
 gcccaccagt gagacctggc tgagcaacag ttctgtgatc cccctacctc ttcctggcgt   2340
 ctctaccatc ccgctcacca tgaaaccaag cagtagcctc ccgaccatcc tgaggacttc   2400
 aagcaagtca acacacccat ccccacccac cactaggact tcagagacac cagtggccac   2460
 tacccagact cctaccaccc ttacatcacg caggacaact cgcatcactt ctcagatgac   2520
 cacacagtcc acgttgacca ccactgcagg cacctgtgac aatggtggca cctgggaaca   2580
 gggccagtgt gcttgccttc cggggttttc tggggaccgc tgtcagctcc agaccagatg   2640
 ccagaatggg ggtcagtggg atggcctcaa atgccagtgc cccagcacct tctatggttc   2700
 cagttgtgag tttgctgtgg aacaggtgga tctagatgca gaagattttt gcagacatgc   2760
 agggcttcac cttcaagggt gtggagatcc tgtccctgag gaatggcagc atcgtggtgg   2820
 actacctggt cctgctggag atgcccttca gcccccagct ggagagcgag tatgagcagg   2880
 tgaagaccac gctgaaggag gggctgcaga acgccagcca ggatgtgaac agctgccagg   2940
 actcccagac cctgtgtttt aagcctgact ccatcaaggt gaacaacaac agcaagacag   3000
 agctgacccc ggcagccatc tgccgcgcgc cgctcccacg ggctatgaag agttctactt   3060
 ccccttggtg gaggccaccc ggctccgctg tgtcaccaaa tgcacgtctg gggtggacaa   3120
 cgccatcgac tgtcaccagg gccagtgcgt tctggagacg agcggtccca cgtgtcgctg   3180
 ctactccacc gacacgcact ggttctctgg cccgcgctgc gaggtggccg tccactggag   3240
 ggcgctggtc ggggcctgac ggccggcgcg cgctgctggt gctgctgctc gtggcgctgg   3300
 gcgtccgggc ggtgcgctcc ggatggtggg gcggccagcg ccgaggccgg tcctgggacc   3360
 aggacaggaa atggttcgag acctgggatg aggaagtcgt gggcactttt tcaaactggg   3420
 gtttcgagga cgacggaaca gacaaggata caaatttcta tgtggccttg gagaacgtgg   3480
 acaccactat gaaggtgcac atcaagagac ccgagatgac ctcgtcctca gtgtgagccc   3540
 tgcggggccc cttcaccacc ccctccgccc tgccccggac acaagggtct gcattgcgtc   3600
 catttcaaga ggtggcccca ggacgcgggc agcccaggct cctgctgttc ttgggcaaga   3660
 tgagactgtt cccccaaatc ccatccttct ccttccaact tggctgaaac ccacctggag   3720
 acgcagttca cgtccaggct cttccactgt ggaatcttgg gcaagtcagt aacgagcctc   3780
 agtttcctca cctgcaaaac gggtacagca ttcctgtatg atacgtcacg ccgttgttgt   3840
 gaaaaccaca tagacttggt caattctcgg tcctactctg ccctcccgtc tcagccctcg   3900
 tgttgccatt gcctctctcg gatcctccaa tcctcacgtc cttcacctgg tctctggccc   3960
 tggttcttat tttctctcaa ttccctactg cctgtttctt actttgaacc tggaggcagc   4020
 ctgcagcccc atcccatctc ctgccctctc ctgatctaac tccctgctgc atctcttgct   4080
 cccattcctt agacgtcctc cccttttgac cccgttcctt catccatcct gcaccccagt   4140
 cccccagccc taaatcctcc ctcctctcct cacatcctgg cccctagcaa ggtatagata   4200
 gcctctgtgt cttaggatac cccgggtgct gttccctcgg tcatcctgtt gcccagttcc   4260
 ccgtttctct tgctctcatt cctgtatcct ttcccctttt gagcccgtcc attcatcggt   4320
 tctgcccccg actcccccag ccctaaatac cccagctgct gttcccccca tcaccctgct   4380
 gcccaattct ttattctcca cccctttctc tcacccctgg agccctgcgg gtgggggcag   4440
 ggcatgagtt ccccagtccc caaggaaagg cagccccctc agtctccctc ctcctcattc   4500
 ccttccatct ccctcccctc tgccttttaa acccatcccc tccgattccc ctcctccccc   4560
 ctctctccct ggtgtcaact cgattcctgc ggtaactctg agccctgaaa tcctcagtct   4620
 ccttggcggg gaagattggc tttgggaaca ggaagtcggc acatctccag gtctccatgt   4680
 gcacaatata gagtttattg taaaaagcaa aaaaaaaa                           4718



      <210> 764
      <211> 1458
      <212> DNA
      <213> Homo sapiens


      <400> 764
 tttttttttt ttgagaaaaa aattgggctt ttattggcaa ttacaaaagt aatagatttt     60
 cttacataat acgttccttc agtaatatat ttttcaagta ttttaccgta gaatttctaa    120
 agtactttgt cattgacccc ataatttatt ataaagtagg tcccataatc acattttttg    180
 gaagttgctg aaattgagat aaaaaatatt gtttttttat gagaaaaact ggacaaaata    240
 cagaatggcc aaaactagat taactggctc agttatgtct actaggtgaa agaaaataca    300
 gaatctgtta ctgtagaaat tttaagaggt tttgagtcag ttccagtata aaaataaggc    360
 caaagtgctc ctgtaaaatt atcattaaaa gtatagagaa gagatctatc attcaaatta    420
 taaaaggaaa cttcattcat ttcatagtct aaaaaaatgc caatcttact aggaattact    480
 tgtggcagca gaataatttc cctgtggccc aatacaatat aattattctg actagatcgc    540
 caaattcccc ataatccatc ctgtactaaa attggttgac tcttcctcct tctgggaaga    600
 cagtcattac agacaccaag aatccattca ggcttgtctt tcacttctac ttcccagtac    660
 tgcctgccac aactatatcc cttagaaccc agaacagctg ggaggagata aaatcttctt    720
 gggttatgag gtacattttg tgttgtattt ccatagcgca cagtttttct atcttctgag    780
 actataagtt tacgatgtgc tgtttcagga tctagaatta catctacttg aaatcgcttg    840
 ataatttagt ctaggccaga atattgtgga ggcagatggt aaccatattt ttttaatttg    900
 aataaaaaca gctcagggaa ttttaaattc ttatatctgt gatagatatc cttaacattt    960
 gccagtaatt ccagttctga cttcacatat atgctctcta tctcctttag tagatatttt   1020
 aatgaggagg tataatctga aaattttgtt aggctttcat ttagttgtgc taaaatatcc   1080
 atctcttcat cttgtaattg cctaagaaca gtctcttgct cattttggag aaataaccta   1140
 agttgctcaa attcagactt gacttcttct gccctatgtt ttaccttttt cttcagttcc   1200
 agtgatttcc tggtttgcat agttatgact ttttcaatta gttccactct ctccttccac   1260
 ggtgcattgt attcctccag ttttttccta tgataggagg cagccttctt tatgggccaa   1320
 acacagtgat gctggtgatc agtggacaaa ctgcaccttg gacataaaag ctataggtct   1380
 ttctgacaga agaaagtcaa aacctgatta tgcttcttac acacatgctt ctcttcctgc   1440
 ctcttcctct tcttgctt                                                 1458



      <210> 765
      <211> 666
      <212> DNA
      <213> Homo sapiens


      <400> 765
 ccgagtctga gatctcttct ctcaatggca ttggagctgg ctgtgcctga ggcagacctg     60
 gaccgtggac atggggcaat gccttgagcg gaaggggaag ccactgaaga gattacacta    120
 catctgagat ggagaccttt cctctgctgc tgctcagcct gggcctggtt cttgcagaag    180
 catcagaaag cacaatgaag ataattaaag aagaatttac agacgaagag atgcaatatg    240
 acatggcaaa aagtggccaa gaaaaacaga ccattgagat attaatgaac ccgatcctgt    300
 tagttaaaaa taccagcctc agcatgtcca aggatgatat gtcttccaca ttactgacat    360
 tcagaagttt acattataat gaccccaagg gaaacagttc gggtaatgac aaagagtgtt    420
 gcaatgacat gacagtctgg agaaaagttt cagaagcaaa cggatcgtgc aagtggagca    480
 ataacttcat ccgcagctcc acagaagtga tgcgcagggt ccacagggcc cccagctgcg    540
 agttttgaca gaaaccctgg cataagctgc tgtgagagcc tagaactgga aaatacagta    600
 agagacttgc ctcagtcaac tctggccgag gtggtctttg aggaggcgtc ctcactggag    660
 gcttga                                                               666



      <210> 766
      <211> 458
      <212> DNA
      <213> Homo sapiens


      <400> 766
 tgaccatgct actccagcac gcgacgaggt ccagaccaac ttccggaaca gtccggacta     60
 caaccagacc cagctcttct acaatgaggt cagccactgg ctggcagcgg agctgggcat    120
 ggcacctcca ggcctccgcc gtggttggtt cactagccgt ctagagctgt atagcctgca    180
 gcacagcctg agcactgagc ctgctgtggt gctgggcctg gctttggcgc tggcctttgc    240
 cacactgctc ctgggcacct ggaatgttcc cctcagccta ttctccgtgg cagctgtggc    300
 aggcaccgtg ctgctcactg taggactcct gggtctcctc gagtggcagc tcaacactgc    360
 cgaggccctg tttctctctg cctcagtggg cctctcagta gacttcactg tcaactactg    420
 catctcctat cacctgtgcc cacaccctga ccgcctga                            458



      <210> 767
      <211> 426
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(426)
      <223> n = a,t,c or g


      <400> 767
 ctgagcatgc tgagcaccat cagcaccgag caccgcctgt ccgtcctgtg gcccatctgg     60
 tactgctgcc actgccccac acacctgtca gcggtcatgt gtgtcctgct ctgggccctg    120
 tccctgttgc agagcatcct ggagtggatg ttctgtagct tcctgtttag tgatgttgac    180
 tctgataatt ggtgtcaaat attagatttc ctcactgctg tgtggctgat ttttttaatc    240
 tgtggttctc tgtgggttca ccctggtcct gcttgtcagg atcatatgtg gatcccagaa    300
 gatgccgctg accaggctgt atgtgaccat cctgctcaca gggctggtct tcctcttctg    360
 cagcctgccc ctcagcattc agtgattcct attatactgg atcgagaagg atttggatga    420
 cttacn                                                               426



      <210> 768
      <211> 493
      <212> DNA
      <213> Homo sapiens


      <400> 768
 gtccggaata cccgggtcga cgatttcgtg gcgccgagtg cgggcggctg ggagcgcgct     60
 gagcggggga gaggcgctgc cgcacggccg gccacaggac cacctccccg gagaataggg    120
 cctctttatg gcatgtggct ggtaactttc ctcctgctcc tggactcttt acacaaagcc    180
 cgccctgaag atgttggcac cagcctctac tttgtaaatg actccttgca gcaggtgacc    240
 ttttccagct ccgtgggggt ggtggtgccc tgcccggccg cgggctcccc cagcgcggcc    300
 cttcgatggt acctggccac aggggacgac atctacgacg tgccgcacat ccggcacgtc    360
 cacgccaacg ggacgctgca gctctacccc ttctccccct ccgccttcaa tagctttatc    420
 cacgacaatg actacttctg caccgcggag aacgctgccg gcaagatccg gagccccaac    480
 attcgcgtta aat                                                       493



      <210> 769
      <211> 435
      <212> DNA
      <213> Homo sapiens


      <400> 769
 tttcctggcc tcgtggcagg cagcagcagc agtgaatgtg gctacagaat tgctaatgga     60
 gtgggccatg ccatgggaac tgttttgggg gtgttcctgg ctcgactgaa gcttaaaaat    120
 gaactggtga ctttagcaga gaagtgagac cctgcagctg agggagcatc atggcagtgt    180
 ttctggaggc caaggatgcc cattcggtcc tgaaacgatt ccctcgtgcc aatgagttcc    240
 tggaggagct gcgccagggc accatcgagc gagagtgcat ggaggagatc tgcagctacg    300
 aggaggtcaa ggaagtgttt gagaacaaag agaaaacgat ggagttctgg aaagggtacc    360
 caaatgcagt ctactctgtc cgagacccct cgcagagctc agatgccatg tatgtggtgg    420
 taccccttct ggggg                                                     435



      <210> 770
      <211> 695
      <212> DNA
      <213> Homo sapiens


      <400> 770
 gactgaagta ccaactaagt catctccttt caaattatca ccgacaccat catggattca     60
 agcaccgcac acagtccggt gtttctggta tttcctccag aaatcactgc ttcagaatat    120
 gagtccacag aactttcagc cacgaccttt tcaactcaaa gccccttgca aaaattattt    180
 gctagaaaaa tgaaaatctt agggactatc cagatcctgt ttggaattat gaccttttct    240
 tttggagtta tcttcctttt cactttgtta aaaccatatc caaggtttcc ctttatattt    300
 ctttcaggat atccattctg gggctctgtt ttgttcatta attctggagc cttcctaatt    360
 gcagtgaaaa gaaaaaccac agaaactctg ataatattga gccgaataat gaattttctt    420
 agtgccctgg gagcaatagc tggaatcatt ctcctcacat ttgagtttca tcctagatca    480
 aaactacatt tgtgattatt ctcaccaaaa tagtcagtgt aaggctgtta ctgtcctgat    540
 cttgggaatt tagaatacat tgatgacttt cagcatatat tgaattattc atattctctg    600
 cctttactca attttggggt gccactcaga ggattgtgat tgtgaacaat gttgttgact    660
 agcactgtga gaataaagat gtgttaaaat ataaa                               695



      <210> 771
      <211> 368
      <212> DNA
      <213> Homo sapiens


      <400> 771
 tgactttgct gtctttctta caattctgtg tatggtttta attgactatg ccattgggat     60
 cccatctcca aaactacaag taccaagtgt tttcaagccc actagagatg atcgtggctg    120
 gtttgttacg cctttaggtc caaacccatg gtggacagta atagctgcta taattccagc    180
 tctgctttgt actattctaa tttttatgga ccaacagatt acagctgtca tcatcaacag    240
 gaaagagcat aagctaaaga aaggttgtgg gtaccatctg gacctattaa tggtggctgt    300
 catgctcggt gtatgctcca tcatgggcct gccatggttt gtggctgcca cagtcctctc    360
 catcactt                                                             368



      <210> 772
      <211> 469
      <212> DNA
      <213> Homo sapiens


      <400> 772
 ccggaattcc tgggtcgacg atttcgtggg ggacaagtcg cggccacctg ctccggagct     60
 ggggagcccg ggcgccgtcc gcccgcgcgt cggttcgtgt gccccgggcc ccatggagct    120
 gcgggtcagc aacaccagct gcgagaacgg ttccctgctc cacctctact gctcctccca    180
 agaagtcctg tgccagattg tcaatgacct cagccctgag gtgcccagca atgccacctt    240
 tcacagctgg caggaaagaa tcaggcagaa ctatggcttc tacatcggcc tgggcctggc    300
 attcctgtct agcttcctca tcggcagcag cgtcatcctc aagaagaaag gcctcttgcg    360
 actcgtggcc atgggagcca ctcgagctgt ggatggaggc ttcggctacc tgaaagatgc    420
 aatgtggtgg gctggatttc tcaccatggc tgctggagaa gttgccaac                469



      <210> 773
      <211> 114
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(114)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 773
 Gln Ser Gly Pro Ser Ala Ala Gly Leu Leu Glu Phe Ala Gly Gly Pro
   1               5                  10                  15    
 Leu Gln Thr Leu Phe Ala Trp Val Ser Ala Ala Glu Val Gly Lys Cys
              20                  25                  30        
 Lys Gly Ser Gly Ser Ser Leu Ser Xaa Pro Lys Lys Gly Val Met Asp
          35                  40                  45            
 Gly Thr Trp Lys Ile Gly Ser Leu Pro Pro Glu Tyr Cys Ala Phe Pro
      50                  55                  60                
 Thr Gly Xaa Lys Asn Gly Ala Pro Leu Arg Leu Tyr Pro Thr Pro Gly
  65                  70                  75                  80
 Ser Glu Gly Pro Thr Pro Thr Glu Ser Pro Xaa Phe Ala Ser Thr Ala
                  85                  90                  95    
 Val Gly Asp Gln Thr Ala Arg Gln Gln Arg Gly Trp Gly Arg Gly Ala
             100                 105                 110        
 Arg His
        



      <210> 774
      <211> 114
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(114)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 774
 Gln Ser Gly Pro Ser Ala Ala Gly Leu Leu Glu Phe Ala Gly Gly Pro
   1               5                  10                  15    
 Leu Gln Thr Leu Phe Ala Trp Val Ser Ala Ala Glu Val Gly Lys Cys
              20                  25                  30        
 Lys Gly Ser Gly Ser Ser Leu Ser Xaa Pro Lys Lys Gly Val Met Asp
          35                  40                  45            
 Gly Thr Trp Lys Ile Gly Ser Leu Pro Pro Glu Tyr Cys Ala Phe Pro
      50                  55                  60                
 Thr Gly Xaa Lys Asn Gly Ala Pro Leu Arg Leu Tyr Pro Thr Pro Gly
  65                  70                  75                  80
 Ser Glu Gly Pro Thr Pro Thr Glu Ser Pro Xaa Phe Ala Ser Thr Ala
                  85                  90                  95    
 Val Gly Asp Gln Thr Ala Arg Gln Gln Arg Gly Trp Gly Arg Gly Ala
             100                 105                 110        
 Arg His
        



      <210> 775
      <211> 114
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(114)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 775
 Gln Ser Gly Pro Ser Ala Ala Gly Leu Leu Glu Phe Ala Gly Gly Pro
   1               5                  10                  15    
 Leu Gln Thr Leu Phe Ala Trp Val Ser Ala Ala Glu Val Gly Lys Cys
              20                  25                  30        
 Lys Gly Ser Gly Ser Ser Leu Ser Xaa Pro Lys Lys Gly Val Met Asp
          35                  40                  45            
 Gly Thr Trp Lys Ile Gly Ser Leu Pro Pro Glu Tyr Cys Ala Phe Pro
      50                  55                  60                
 Thr Gly Xaa Lys Asn Gly Ala Pro Leu Arg Leu Tyr Pro Thr Pro Gly
  65                  70                  75                  80
 Ser Glu Gly Pro Thr Pro Thr Glu Ser Pro Xaa Phe Ala Ser Thr Ala
                  85                  90                  95    
 Val Gly Asp Gln Thr Ala Arg Gln Gln Arg Gly Trp Gly Arg Gly Ala
             100                 105                 110        
 Arg His
        



      <210> 776
      <211> 280
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(280)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 776
 Ser Thr Pro Leu Gln Arg Ala Leu Ala Cys Ala Leu Arg Arg Ser Gln
   1               5                  10                  15    
 Pro Gly Trp Ser Arg Thr Asp Cys Val Met Ile Ser Thr Arg Leu Val
              20                  25                  30        
 Ser Ser Val His Ala Val Leu Ala Thr Gly Ser Gly Ile Val Ile Ile
          35                  40                  45            
 Arg Ser Cys Asp Asp Val Ile Thr Gly Arg His Trp Leu Ala Arg Glu
      50                  55                  60                
 Tyr Val Trp Phe Leu Ile Pro Tyr Met Ile Tyr Asp Ser Tyr Ala Met
  65                  70                  75                  80
 Tyr Leu Cys Glu Trp Cys Arg Thr Arg Asp Gln Asn Arg Ala Pro Ser
                  85                  90                  95    
 Leu Thr Leu Arg Asn Phe Leu Ser Arg Asn Arg Leu Met Ile Thr His
             100                 105                 110        
 His Ala Val Ile Leu Phe Val Leu Val Pro Val Ala Gln Arg Leu Arg
         115                 120                 125            
 Gly Asp Leu Gly Asp Phe Phe Val Gly Cys Ile Phe Thr Ala Glu Leu
     130                 135                 140                
 Ser Thr Pro Phe Val Ser Leu Gly Arg Val Leu Ile Gln Leu Lys Gln
 145                 150                 155                 160
 Gln His Thr Leu Leu Tyr Lys Val Asn Gly Ile Leu Thr Leu Ala Thr
                 165                 170                 175    
 Phe Leu Ser Cys Arg Ile Leu Leu Phe Pro Phe Met Tyr Trp Ser Tyr
             180                 185                 190        
 Gly Arg Gln Gln Gly Leu Ser Leu Leu Gln Val Pro Phe Ser Ile Pro
         195                 200                 205            
 Phe Tyr Cys Asn Val Ala Asn Ala Phe Leu Val Ala Pro Gln Ile Tyr
     210                 215                 220                
 Trp Phe Cys Leu Leu Cys Arg Lys Ala Val Arg Leu Phe Asp Thr Pro
 225                 230                 235                 240
 Gln Ala Lys Lys Asp Gly Xaa Met Leu Leu Gly Val Arg Arg Ser Leu
                 245                 250                 255    
 Thr Pro Ala Ala Ser Ser Thr Gln His Ser Met Asp Gln Ile Val Pro
             260                 265                 270        
 Trp Val Ala Ser Asp Phe Gly Tyr
         275                 280



      <210> 777
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 777
 Arg Lys Glu Arg Arg Arg Arg Arg Arg Arg Met Glu Ala Val Val Phe
   1               5                  10                  15    
 Val Phe Ser Leu Leu Asp Cys Cys Ala Leu Ile Phe Leu Ser Val Tyr
              20                  25                  30        
 Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys Asp Tyr Ile Asn Ala Arg
          35                  40                  45            
 Ser Cys Cys Ser Lys Leu Asn Lys Trp Val Ile Pro Glu Leu Ile Gly
      50                  55                  60                
 His Thr Ile Val Thr Val Leu Leu Leu Met Ser Leu His Trp Phe Ile
  65                  70                  75                  80
 Phe Leu Leu Asn Leu Pro Val Ala Thr Trp Asn Ile Tyr Arg Tyr Ile
                  85                  90                  95    
 Met Val Pro Ser Gly Asn Met Gly Val Phe Asp Pro Thr Glu Ile His
             100                 105                 110        
 Asn Arg Gly Gln Leu Lys Ser His Met Lys Glu Ala Met Ile Lys Leu
         115                 120                 125            
 Gly Phe His Leu Leu Cys Phe Phe Met Tyr Leu Tyr Ser Met Ile Leu
     130                 135                 140                
 Ala Leu Ile Asn Asp
 145                



      <210> 778
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 778
 Met Phe Leu His Ser Arg Phe Ile Gly Ala Ser Leu Asp Val Lys Cys
   1               5                  10                  15    
 Leu Ala Phe Val Pro Ser Leu Ile Ala Phe Val Trp Phe Gly Phe Phe
              20                  25                  30        
 Ile Trp Phe Phe Gly Arg Phe Leu Lys Asn Glu Pro Arg Met Glu Asn
          35                  40                  45            
 Gln Asp Lys Thr Tyr Thr Arg Met Lys Arg Lys Ser Pro Ser Glu His
      50                  55                  60                
 Ser Lys Asp Met Gly Ile Thr Arg Glu Asn Thr Gln Ala Ser Val Glu
  65                  70                  75                  80
 Asp Pro Leu Asn Asp Pro Ser Leu Val Cys Ile Arg Ser Asp Phe Asn
                  85                  90                  95    
 Glu Ile Val Tyr Lys Ser Ser His Leu Thr Ser Glu Asn Leu Ser Ser
             100                 105                 110        
 Gln Leu Asn Glu Ser Thr Ser Ala Thr Glu Ala Asp Gln Asp Pro Thr
         115                 120                 125            
 Thr Ser Lys Ser Thr Pro Thr Asn
     130                 135    



      <210> 779
      <211> 702
      <212> PRT
      <213> Homo sapiens


      <400> 779
 Ala Tyr Tyr Arg His Lys Val Ser Glu Phe Lys Glu Gly Lys Ala Gln
   1               5                  10                  15    
 Glu Pro Ser Ala Ala Ile Pro Lys Val Met Gln Gln Gln Gln Gln Thr
              20                  25                  30        
 Thr Gln Gln Gln Leu Pro Gln Lys Val Gln Ala Gln Val Ile Gln Glu
          35                  40                  45            
 Thr Ile Val Pro Lys Glu Pro Pro Pro Glu Phe Glu Phe Ile Ala Asp
      50                  55                  60                
 Pro Pro Ser Ile Ser Ala Phe Asp Leu Asp Val Val Lys Leu Thr Ala
  65                  70                  75                  80
 Gln Phe Val Ala Arg Asn Gly Arg Gln Phe Leu Thr Gln Leu Met Gln
                  85                  90                  95    
 Lys Glu Gln Arg Asn Tyr Gln Phe Asp Phe Leu Arg Pro Gln His Ser
             100                 105                 110        
 Leu Phe Asn Tyr Phe Thr Lys Leu Val Glu Gln Tyr Thr Lys Ile Leu
         115                 120                 125            
 Ile Pro Pro Lys Gly Leu Phe Ser Lys Leu Lys Lys Glu Ala Glu Asn
     130                 135                 140                
 Pro Arg Glu Val Leu Asp Gln Val Cys Tyr Arg Val Glu Trp Ala Lys
 145                 150                 155                 160
 Phe Gln Glu Arg Glu Arg Lys Lys Glu Glu Glu Glu Lys Glu Lys Glu
                 165                 170                 175    
 Arg Val Ala Tyr Ala Gln Ile Asp Trp His Asp Phe Val Val Val Glu
             180                 185                 190        
 Thr Val Asp Phe Gln Pro Asn Glu Gln Gly Asn Phe Pro Pro Pro Thr
         195                 200                 205            
 Thr Pro Glu Glu Leu Gly Ala Arg Ile Leu Ile Gln Glu Arg Tyr Glu
     210                 215                 220                
 Lys Phe Gly Glu Ser Glu Glu Val Glu Met Glu Val Glu Ser Asp Glu
 225                 230                 235                 240
 Glu Asp Asp Lys Gln Glu Lys Ala Glu Glu Pro Pro Ser Gln Leu Asp
                 245                 250                 255    
 Gln Asp Thr Gln Val Gln Asp Met Asp Glu Gly Ser Asp Asp Glu Glu
             260                 265                 270        
 Glu Gly Gln Lys Val Pro Pro Pro Pro Glu Thr Pro Met Pro Pro Pro
         275                 280                 285            
 Leu Pro Pro Thr Pro Asp Gln Val Ile Val Arg Lys Asp Tyr Asp Pro
     290                 295                 300                
 Lys Ala Ser Lys Pro Leu Pro Pro Ala Pro Ala Pro Asp Glu Tyr Leu
 305                 310                 315                 320
 Val Ser Pro Ile Thr Gly Glu Lys Ile Pro Ala Ser Lys Met Gln Glu
                 325                 330                 335    
 His Met Arg Ile Gly Leu Leu Asp Pro Arg Trp Leu Glu Gln Arg Asp
             340                 345                 350        
 Arg Ser Ile Arg Glu Lys Gln Ser Asp Asp Glu Val Tyr Ala Pro Gly
         355                 360                 365            
 Leu Asp Ile Glu Ser Ser Leu Lys Gln Leu Ala Glu Arg Arg Thr Asp
     370                 375                 380                
 Ile Phe Gly Val Glu Glu Thr Ala Ile Gly Lys Lys Ile Gly Glu Glu
 385                 390                 395                 400
 Glu Ile Gln Lys Pro Glu Glu Lys Val Thr Trp Asp Gly His Ser Gly
                 405                 410                 415    
 Ser Met Ala Arg Thr Gln Gln Ala Ala Gln Ala Asn Ile Thr Leu Gln
             420                 425                 430        
 Glu Gln Ile Glu Ala Ile His Lys Ala Lys Gly Leu Val Pro Glu Asp
         435                 440                 445            
 Asp Thr Lys Glu Lys Ile Gly Pro Ser Lys Pro Asn Glu Ile Pro Gln
     450                 455                 460                
 Gln Pro Pro Pro Pro Ser Ser Ala Thr Asn Ile Pro Ser Ser Ala Pro
 465                 470                 475                 480
 Pro Ile Thr Ser Val Pro Arg Pro Pro Thr Met Pro Pro Pro Val Arg
                 485                 490                 495    
 Thr Thr Val Val Ser Ala Val Pro Val Met Pro Arg Pro Pro Met Ala
             500                 505                 510        
 Ser Val Val Arg Leu Pro Pro Gly Ser Val Ile Ala Pro Met Pro Pro
         515                 520                 525            
 Ile Ile His Ala Pro Arg Ile Asn Val Val Pro Met Pro Pro Ser Ala
     530                 535                 540                
 Pro Pro Ile Met Ala Pro Arg Pro Pro Pro Met Ile Val Pro Thr Ala
 545                 550                 555                 560
 Phe Val Pro Ala Pro Pro Val Ala Pro Val Pro Ala Pro Ala Pro Met
                 565                 570                 575    
 Pro Pro Val His Pro Pro Pro Pro Met Glu Asp Glu Pro Thr Ser Lys
             580                 585                 590        
 Lys Leu Lys Thr Glu Asp Ser Leu Met Pro Glu Glu Glu Phe Leu Arg
         595                 600                 605            
 Arg Asn Lys Gly Pro Val Ser Ile Lys Val Gln Val Pro Asn Met Gln
     610                 615                 620                
 Asp Lys Thr Glu Trp Lys Leu Asn Gly Gln Val Leu Val Phe Thr Leu
 625                 630                 635                 640
 Pro Leu Thr Asp Gln Val Ser Val Ile Lys Val Lys Ile His Glu Ala
                 645                 650                 655    
 Thr Gly Met Pro Ala Gly Lys Gln Lys Leu Gln Tyr Glu Gly Ile Phe
             660                 665                 670        
 Ile Lys Asp Ser Asn Ser Leu Ala Tyr Tyr Asn Met Ala Asn Gly Ala
         675                 680                 685            
 Val Ile His Leu Ala Leu Lys Glu Arg Gly Gly Arg Lys Lys
     690                 695                 700        



      <210> 780
      <211> 226
      <212> PRT
      <213> Homo sapiens


      <400> 780
 Met Gly Cys Asp Gly Arg Val Ser Gly Leu Leu Arg Arg Asn Leu Gln
   1               5                  10                  15    
 Pro Thr Leu Thr Tyr Trp Ser Val Phe Phe Ser Phe Gly Leu Cys Ile
              20                  25                  30        
 Ala Phe Leu Gly Pro Thr Leu Leu Asp Leu Arg Cys Gln Thr His Ser
          35                  40                  45            
 Ser Leu Pro Gln Ile Ser Trp Val Phe Phe Ser Gln Gln Leu Cys Leu
      50                  55                  60                
 Leu Leu Gly Ser Ala Leu Gly Gly Val Phe Lys Arg Thr Leu Ala Gln
  65                  70                  75                  80
 Ser Leu Trp Ala Leu Phe Thr Ser Ser Leu Ala Ile Ser Leu Val Phe
                  85                  90                  95    
 Ala Val Ile Pro Phe Cys Arg Asp Val Lys Val Leu Ala Ser Val Met
             100                 105                 110        
 Ala Leu Ala Gly Leu Ala Met Gly Cys Ile Asp Thr Val Ala Asn Met
         115                 120                 125            
 Gln Leu Val Arg Met Tyr Gln Lys Asp Ser Ala Val Phe Leu Gln Val
     130                 135                 140                
 Leu His Phe Phe Val Gly Phe Gly Ala Leu Leu Ser Pro Leu Ile Ala
 145                 150                 155                 160
 Asp Pro Phe Leu Ser Glu Ala Asn Cys Leu Pro Ala Asn Ser Thr Gly
                 165                 170                 175    
 Gln His His Leu Pro Arg Ala Thr Cys Ser Met Ser Pro Gly Cys Trp
             180                 185                 190        
 Gly Gln His His Val Asp Ala Gln Ala Leu Val Gln Pro Asp Val Pro
         195                 200                 205            
 Lys Ala Asp Ser Gln Gly Pro Gly Arg Glu Pro Glu Gly Pro Met Pro
     210                 215                 220                
 Ser Gly
 225    



      <210> 781
      <211> 108
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(108)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 781
 Xaa Cys Lys Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys
   1               5                  10                  15    
 Gln Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met
              20                  25                  30        
 Phe Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val
          35                  40                  45            
 Cys Asp Ser Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys
      50                  55                  60                
 Gly Pro Arg Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly Tyr
  65                  70                  75                  80
 Pro Lys Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val Ile
                  85                  90                  95    
 Ala Val Ile Val Ile Ala Ile Val Val Gly Val Ala
             100                 105            



      <210> 782
      <211> 185
      <212> PRT
      <213> Homo sapiens


      <400> 782
 Leu Gln Ile Ala Leu Asp Ala Ser Tyr Trp Thr Phe Ile Asn His Val
   1               5                  10                  15    
 Phe Ile Trp Gly Ser Ile Ala Ile Tyr Phe Ser Ile Leu Phe Thr Met
              20                  25                  30        
 His Ser Asn Gly Ile Phe Gly Ile Phe Pro Asn Gln Phe Pro Phe Val
          35                  40                  45            
 Gly Asn Ala Arg His Ser Leu Thr Gln Lys Cys Ile Trp Leu Val Ile
      50                  55                  60                
 Leu Leu Thr Thr Val Ala Ser Val Met Pro Val Val Ala Phe Arg Phe
  65                  70                  75                  80
 Leu Lys Val Asp Leu Tyr Pro Thr Leu Ser Asp Gln Ile Arg Arg Trp
                  85                  90                  95    
 Gln Lys Ala Gln Lys Lys Ala Arg Pro Pro Ser Ser Arg Arg Pro Arg
             100                 105                 110        
 Thr Arg Arg Ser Ser Ser Arg Arg Ser Gly Tyr Ala Phe Ala His Gln
         115                 120                 125            
 Glu Gly Tyr Gly Glu Leu Ile Thr Ser Gly Lys Asn Met Arg Ala Lys
     130                 135                 140                
 Asn Pro Pro Pro Thr Ser Gly Leu Glu Lys Thr His Tyr Asn Ser Thr
 145                 150                 155                 160
 Ser Trp Ile Glu Asn Leu Cys Lys Lys Thr Thr Asp Thr Val Ser Ser
                 165                 170                 175    
 Phe Ser Gln Asp Lys Thr Val Lys Leu
             180                 185



      <210> 783
      <211> 98
      <212> PRT
      <213> Homo sapiens


      <400> 783
 Met Phe Leu Ser Leu Ser Leu Thr Leu Cys Leu Cys Phe Ser Phe Phe
   1               5                  10                  15    
 Cys Leu Tyr Leu Ser Leu Ala Leu Tyr Leu Gly Ser Phe Phe Cys Leu
              20                  25                  30        
 Pro Phe His Val Ser Val Phe Leu Cys Leu Phe Pro Ser Val Leu Phe
          35                  40                  45            
 Leu Ser Val Ala Leu Gly Ser Pro Glu Asn His Ile Ser Trp Arg Lys
      50                  55                  60                
 Val Gly Glu Glu Leu Lys Leu Ala Ser His Arg Asn Phe Cys Ser Leu
  65                  70                  75                  80
 Met Gln Lys Met Arg Ser Asn Lys Pro Ser Pro Ser Arg Pro Arg Gly
                  85                  90                  95    
 Trp Ala
        



      <210> 784
      <211> 157
      <212> PRT
      <213> Homo sapiens


      <400> 784
 Met Phe Val Ile Ala Phe Leu Ser Pro Leu Ser Leu Ile Phe Leu Ala
   1               5                  10                  15    
 Lys Phe Leu Lys Lys Ala Asp Thr Arg Asp Ser Arg Gln Ala Cys Leu
              20                  25                  30        
 Ala Ala Ser Leu Ala Leu Ala Leu Asn Gly Val Phe Thr Asn Thr Ile
          35                  40                  45            
 Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr Arg Cys Phe
      50                  55                  60                
 Pro Asp Gly Leu Ala His Ser Asp Leu Met Cys Thr Gly Asp Lys Asp
  65                  70                  75                  80
 Val Val Asn Glu Gly Arg Lys Ser Phe Pro Ser Gly His Ser Ser Phe
                  85                  90                  95    
 Ala Phe Ala Gly Leu Ala Phe Ala Ser Phe Tyr Leu Ala Gly Lys Leu
             100                 105                 110        
 His Cys Phe Thr Pro Gln Gly Arg Gly Lys Ser Trp Arg Phe Cys Ala
         115                 120                 125            
 Phe Leu Ser Pro Leu Leu Phe Ala Ala Val Ile Ala Leu Ser Arg Thr
     130                 135                 140                
 Cys Asp Tyr Lys His His Trp Gln Gly Pro Phe Lys Trp
 145                 150                 155        



      <210> 785
      <211> 25
      <212> PRT
      <213> Homo sapiens


      <400> 785
 Gly Ile Ile Ile Gly Thr Ile Phe Ile Ile Lys Gly Val Arg Arg Ser
   1               5                  10                  15    
 Asn Ala Ser Glu Arg Arg Gly Pro Leu
              20                  25



      <210> 786
      <211> 152
      <212> PRT
      <213> Homo sapiens


      <400> 786
 Met Ala Pro Ser Phe Thr Ala Arg Ile Gln Leu Phe Leu Leu Arg Ala
   1               5                  10                  15    
 Leu Gly Phe Leu Ile Gly Leu Val Gly Arg Ala Ala Leu Val Leu Gly
              20                  25                  30        
 Gly Pro Lys Phe Ala Ser Lys Thr Pro Arg Pro Val Thr Glu Pro Leu
          35                  40                  45            
 Leu Leu Leu Ser Gly Met Gln Leu Ala Lys Leu Ile Arg Gln Arg Lys
      50                  55                  60                
 Val Lys Cys Ile Asp Val Val Gln Ala Tyr Ile Asn Arg Ile Lys Asp
  65                  70                  75                  80
 Val Asn Pro Met Ile Asn Gly Ile Val Lys Tyr Arg Phe Glu Glu Ala
                  85                  90                  95    
 Met Lys Glu Ala His Ala Val Asp Gln Lys Leu Ala Glu Lys Gln Glu
             100                 105                 110        
 Asp Glu Ala Thr Leu Glu Asn Lys Trp Pro Phe Leu Gly Val Pro Leu
         115                 120                 125            
 Thr Val Lys Glu Ala Phe Gln Leu Gln Gly Asn Ala Asn Ser Ser Gly
     130                 135                 140                
 Leu Met Asn Arg Arg Asp Ala Ile
 145                 150        



      <210> 787
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 787
 Pro Thr Arg Pro Pro Thr Arg Pro Ala Ser Asn Pro Ser Thr Ile Thr
   1               5                  10                  15    
 Leu Phe Leu Pro Ile Leu Ser Ala Leu Ala Glu Ala Ile His Val Asn
              20                  25                  30        
 Pro Leu Tyr Ile Leu Ile Pro Ser Thr Leu Cys Thr Ser Phe Ala Phe
          35                  40                  45            
 Leu Leu Pro Val Ala Asn Pro Pro Asn Ala Ile Val Phe Ser Tyr Gly
      50                  55                  60                
 His Leu Lys Val Ile Asp Met Val Lys Ala Gly Leu Gly Val Asn Ile
  65                  70                  75                  80
 Asp Gly Val Ala Val Val Met Leu Gly Ile Cys Thr Trp Ile Val Pro
                  85                  90                  95    
 Met Phe Asp Leu Tyr Thr Tyr Pro Ser Trp Ala Pro Ala Met Ser Asn
             100                 105                 110        
 Glu
    



      <210> 788
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 788
 Gln Gly Leu Pro Ser Phe Leu Pro Ala Phe Gly Pro Ser Gly Ser Trp
   1               5                  10                  15    
 Leu Gly Pro Ala Pro Thr Leu Gly Ser Ser Cys Asn Thr Val Asp Thr
              20                  25                  30        
 Ile Cys His Gly Tyr Ser Glu Ile Arg Pro Leu Phe Tyr Leu Ser Phe
          35                  40                  45            
 Cys Asp Leu Leu Leu Gly Leu Cys Trp Leu Thr Glu Thr Leu Leu Tyr
      50                  55                  60                
 Gly Ala Ser Val Ala Asn Lys Asp Ile Ile Cys Tyr Asn Leu Gln Ala
  65                  70                  75                  80
 Val Gly Gln Ile Phe Tyr Ile Ser Ser Phe Leu Tyr Thr Val Asn Tyr
                  85                  90                  95    
 Ile Trp Tyr Leu Tyr Thr Glu Leu Arg Met Lys His Thr Gln Ser Gly
             100                 105                 110        
 Gln Ser Thr Ser Pro Leu Val Ile Asp Tyr Thr Cys Arg Val Cys Gln
         115                 120                 125            
 Met Ala Phe Val Phe Ser Ser Leu Ile
     130                 135        



      <210> 789
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 789
 Val Cys Pro His Leu Pro Leu Gln Pro Gly Met Gly Gln Gly Met Gly
   1               5                  10                  15    
 Met Val Gly Asp Leu Arg Ser Pro Arg Pro Thr Cys Pro Leu Pro Leu
              20                  25                  30        
 Pro Gln Leu Thr Leu Val Val Val Gln Val Ser Ile Leu Tyr Tyr Gly
          35                  40                  45            
 Gly His Leu Val Ile Ser Gly Gln Met Thr Ser Gly Asn Leu Ile Ala
      50                  55                  60                
 Phe Ile Ile Tyr Glu Phe Val Leu Gly Asp Cys Met Glu Ser Val Gly
  65                  70                  75                  80
 Ser Val Tyr Ser Gly Leu Met Gln Gly Val Gly Ala Ala Asp Asn Val
                  85                  90                  95    
 Phe Glu Phe Ile Asp Arg Gln Pro Thr Met Val His Asp Gly Ser Leu
             100                 105                 110        
 Ala Pro Asp His Leu Glu Gly Arg Gly Asp Phe Glu Asn Gly Thr Leu
         115                 120                 125            
 Thr
    



      <210> 790
      <211> 57
      <212> PRT
      <213> Homo sapiens


      <400> 790
 Met Gln Gly Val Arg Val Ser Phe Gly Trp Ala Met Gly Leu Ala Trp
   1               5                  10                  15    
 Gly Ser Cys Ala Leu Glu Ala Phe Ser Gly Thr Leu Leu Leu Ser Ala
              20                  25                  30        
 Ala Trp Thr Leu Ser Leu Ser Pro Pro Ile Cys Gly His Leu Ser Pro
          35                  40                  45            
 Gln Gln Val Gly Gly Arg Gly Gly Asp
      50                  55        



      <210> 791
      <211> 350
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(350)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 791
 Gly Leu Pro Gly Ser Thr Thr Ala Ser Ala Ala Ala Ala Ser Ala Ala
   1               5                  10                  15    
 Ser Ala Ser Ser Asp Ala Pro Pro Phe Gln Leu Gly Lys Pro Arg Phe
              20                  25                  30        
 Gln Gln Thr Ser Phe Tyr Gly Arg Phe Arg His Phe Leu Asp Ile Ile
          35                  40                  45            
 Asp Pro Arg Thr Leu Phe Val Thr Glu Arg Arg Leu Arg Glu Ala Val
      50                  55                  60                
 Gln Leu Leu Glu Asp Tyr Lys His Gly Thr Leu Arg Pro Gly Val Thr
  65                  70                  75                  80
 Asn Glu Gln Leu Trp Ser Ala Gln Lys Ile Lys Gln Ala Ile Leu His
                  85                  90                  95    
 Pro Asp Thr Asn Glu Lys Ile Phe Met Pro Phe Arg Met Ser Gly Tyr
             100                 105                 110        
 Ile Pro Phe Gly Thr Pro Ile Val Val Gly Leu Leu Leu Pro Asn Gln
         115                 120                 125            
 Thr Leu Ala Ser Thr Val Phe Trp Gln Trp Leu Asn Gln Ser His Asn
     130                 135                 140                
 Ala Cys Val Asn Tyr Ala Asn Arg Asn Ala Thr Lys Pro Ser Pro Ala
 145                 150                 155                 160
 Ser Lys Phe Ile Gln Gly Tyr Leu Gly Ala Val Ile Ser Ala Val Ser
                 165                 170                 175    
 Ile Ala Val Gly Leu Asn Val Leu Val Gln Lys Ala Asn Lys Phe Thr
             180                 185                 190        
 Pro Ala Thr Arg Leu Leu Ile Gln Arg Phe Val Pro Phe Pro Ala Val
         195                 200                 205            
 Ala Ser Ala Asn Ile Cys Asn Val Val Leu Met Arg Tyr Gly Glu Leu
     210                 215                 220                
 Glu Glu Gly Ile Asp Val Leu Asp Ser Asp Gly Asn Leu Val Gly Ser
 225                 230                 235                 240
 Ser Lys Ile Ala Ala Arg His Ala Leu Leu Asp Thr Ala Leu Thr Arg
                 245                 250                 255    
 Val Val Leu Pro Met Pro Ile Leu Val Leu Pro Pro Ile Val Met Ser
             260                 265                 270        
 Met Leu Glu Lys Lys Ala Leu Leu Gln Ala Arg Pro Arg Leu Leu Leu
         275                 280                 285            
 Pro Val Gln Ser Leu Val Cys Leu Ala Ala Phe Gly Leu Ala Leu Pro
     290                 295                 300                
 Leu Ala Ile Ser Leu Phe Pro Gln Met Ser Glu Ile Glu Thr Ser Gln
 305                 310                 315                 320
 Leu Glu Pro Glu Leu Ala Gln Ala Thr Ser Ser Arg Thr Val Val Tyr
                 325                 330                 335    
 Asn Lys Gly Leu Xaa Val Asp Tyr Ser Ile Gly Gly Gly Gly
             340                 345                 350



      <210> 792
      <211> 311
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(311)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 792
 Ser His Thr Phe Gly Trp Asn Lys Gly Pro Arg His Cys Pro Ser Cys
   1               5                  10                  15    
 Ser Gly Thr Thr Ala Gln Ser Cys Thr Arg Leu Gly Gly Ser Arg Cys
              20                  25                  30        
 Arg Glu Leu Pro Xaa Trp Ser Tyr Val His Phe Pro Lys Thr Ala Glu
          35                  40                  45            
 Gly Ser Leu Val Val Val His Gln Ala Gln His Arg Pro Leu Gly Val
      50                  55                  60                
 Ser His Ala Cys Thr His Ile Leu Thr Pro Pro Ala His Ser His Ser
  65                  70                  75                  80
 Gly Thr Pro Gly Leu Gly Pro Ser Ser Pro Gly Gln His Gly Ala Cys
                  85                  90                  95    
 Gly Gly Thr Met Trp His Gln Asp Ile Lys Phe Leu Gly Leu Met Glu
             100                 105                 110        
 Gly Ser Pro Phe Leu Lys Gly Ser Pro Asp Ala Gln Ala Val Phe Pro
         115                 120                 125            
 Ile Val Gly Glu Pro Leu Gly Gly Xaa Ala Pro Glu Gln Ala Ser Met
     130                 135                 140                
 Arg Ser Ser Thr Lys Leu Ser Thr Asn Ser Gln Val Gln Gly Arg Ser
 145                 150                 155                 160
 Ala Asp Gly Ile Leu Asp Ile Val Phe Val Lys Gly Val Pro Gly Pro
                 165                 170                 175    
 Pro Gly Arg Gly Ser Gln Xaa Ala Ser Cys Lys Arg Xaa Gln Gly Gln
             180                 185                 190        
 His Gly Leu Pro Pro Pro Pro Pro His Cys Trp Asn Gln Arg Pro Val
         195                 200                 205            
 His Ala Ala Cys Ser Val Ala Gly Ala Gln Arg Arg Glu Lys Gly Lys
     210                 215                 220                
 Arg Gly Gln Cys Ser Thr Gly Phe Pro Ala Ser Ser Pro Glu Ala Leu
 225                 230                 235                 240
 Pro Gly His Arg Pro Gly Thr Ala Thr Pro Cys Leu Ser Ser Pro Ala
                 245                 250                 255    
 Leu Thr Gly His Trp Met Cys Leu Leu Ser Arg Ser Ser Leu Pro Ser
             260                 265                 270        
 Ala Ser Ala Gln Arg Leu Ala Phe Ser Leu Gln Thr Pro Ser Leu Ala
         275                 280                 285            
 Gly Ala Ser Pro His Ser Phe Ala Ser Pro Ala Ala Asp Ser Trp Ile
     290                 295                 300                
 Met Cys Pro Gly Pro Ser Asp
 305                 310    



      <210> 793
      <211> 57
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(57)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 793
 Arg Pro Pro Arg Ser Glu Val Pro Gly Pro Leu Ser Pro Gly Arg Pro
   1               5                  10                  15    
 Pro Ala Ala Gly Leu Arg Gly Arg Xaa Pro Ala Gly Val Arg Gly Leu
              20                  25                  30        
 Arg Glu Pro Arg Ala Phe Ser Gly Val Arg Val Glu Arg Arg Ser Leu
          35                  40                  45            
 Phe Ile Gly Lys Asp Met Phe Asp Ser
      50                  55        



      <210> 794
      <211> 150
      <212> PRT
      <213> Homo sapiens


      <400> 794
 Arg Gly Ile Arg Ser Trp Arg Leu Phe Thr Gly Cys Cys Val Asn Pro
   1               5                  10                  15    
 Arg Lys Ile Phe Pro Arg Gly His Ser Cys Arg Phe Phe Tyr Val Leu
              20                  25                  30        
 Gly Gln Ile Thr Leu Ser Ser Leu Val Ala Pro Val Met Trp Leu Ser
          35                  40                  45            
 Val Ala Leu Leu Asn Gly Thr Phe Tyr Glu Cys Ala Met Ser Gly Thr
      50                  55                  60                
 Arg Ser Ser Gly Leu Leu Glu Leu Ile Cys Lys Gly Lys Pro Lys Glu
  65                  70                  75                  80
 Cys Trp Glu Glu Leu His Lys Val Ser Cys Gly Lys Thr Ser Met Leu
                  85                  90                  95    
 Pro Thr Val Asn Glu Glu Leu Lys Leu Ser Leu Gln Ala Gln Ser Gln
             100                 105                 110        
 Ile Leu Gly Trp Cys Leu Ile Cys Ser Ala Ser Phe Phe Ser Leu Leu
         115                 120                 125            
 Thr Thr Cys Tyr Ala Arg Cys Arg Ser Lys Val Ser Tyr Leu Gln Leu
     130                 135                 140                
 Ser Phe Trp Lys Thr Tyr
 145                 150



      <210> 795
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 795
 Arg Lys Glu Arg Arg Arg Arg Arg Arg Arg Met Glu Ala Val Val Phe
   1               5                  10                  15    
 Val Phe Ser Leu Leu Asp Cys Cys Ala Leu Ile Phe Leu Ser Val Tyr
              20                  25                  30        
 Phe Ile Ile Thr Leu Ser Asp Leu Glu Cys Asp Tyr Ile Asn Ala Arg
          35                  40                  45            
 Ser Cys Cys Ser Lys Leu Asn Lys Trp Val Ile Pro Glu Leu Ile Gly
      50                  55                  60                
 His Thr Ile Val Thr Val Leu Leu Leu Met Ser Leu His Trp Phe Ile
  65                  70                  75                  80
 Phe Leu Leu Asn Leu Pro Val Ala Thr Trp Asn Ile Tyr Arg Tyr Ile
                  85                  90                  95    
 Met Val Pro Ser Gly Asn Met Gly Val Phe Asp Pro Thr Glu Ile His
             100                 105                 110        
 Asn Arg Gly Gln Leu Lys Ser His Met Lys Glu Ala Met Ile Lys Leu
         115                 120                 125            
 Gly Phe His Leu Leu Cys Phe Phe Met Tyr Leu Tyr Ser Met Ile Leu
     130                 135                 140                
 Ala Leu Ile Asn Asp
 145                



      <210> 796
      <211> 200
      <212> PRT
      <213> Homo sapiens


      <400> 796
 Met Ser Ala Asp Trp Leu Ile Gly Lys Ala Arg Ser Arg Gly Gly Val
   1               5                  10                  15    
 Glu Pro Ala Gly Pro Gly Gly Gly Ser Pro Glu Pro Tyr His Pro Thr
              20                  25                  30        
 Leu Gly Ile Tyr Ala Arg Cys Ile Arg Asn Pro Gly Val Gln His Phe
          35                  40                  45            
 Gln Arg Asp Thr Leu Cys Gly Pro Tyr Ala Glu Ser Phe Gly Glu Ile
      50                  55                  60                
 Ala Ser Gly Phe Trp Gln Ala Thr Ala Ile Phe Leu Ala Val Gly Ile
  65                  70                  75                  80
 Phe Ile Leu Cys Met Val Ala Leu Val Ser Val Phe Thr Met Cys Val
                  85                  90                  95    
 Gln Ser Ile Met Lys Lys Ser Ile Phe Asn Val Cys Gly Leu Leu Gln
             100                 105                 110        
 Gly Ile Ala Gly Leu Phe Leu Ile Leu Gly Leu Ile Leu Tyr Pro Ala
         115                 120                 125            
 Gly Trp Gly Cys Gln Lys Ala Ile Asp Tyr Cys Gly His Tyr Ala Ser
     130                 135                 140                
 Ala Tyr Lys Pro Gly Asp Cys Ser Leu Gly Trp Ala Phe Tyr Thr Ala
 145                 150                 155                 160
 Ile Gly Gly Thr Val Leu Thr Phe Ile Cys Ala Val Phe Ser Ala Gln
                 165                 170                 175    
 Ala Glu Ile Ala Thr Ser Ser Asp Lys Val Gln Glu Glu Ile Glu Glu
             180                 185                 190        
 Gly Lys Asn Leu Ile Cys Leu Leu
         195                 200



      <210> 797
      <211> 140
      <212> PRT
      <213> Homo sapiens


      <400> 797
 Tyr Met His Ser Arg Gly Arg Glu Ile Val Val Leu Leu Asn Pro Trp
   1               5                  10                  15    
 Ser Ile Asn Glu Ala Val Ser Ser Tyr Cys Thr Tyr Phe Ile Lys Gln
              20                  25                  30        
 Asp Ser Lys Ser Phe Gly Ile Met Val Ser Trp Lys Gly Ile Tyr Phe
          35                  40                  45            
 Ile Leu Thr Leu Phe Trp Gly Ser Phe Phe Gly Ser Ile Phe Met Leu
      50                  55                  60                
 Ser Pro Phe Leu Pro Leu Met Phe Val Asn Pro Ser Trp Tyr Arg Trp
  65                  70                  75                  80
 Ile Asn Asn Arg Leu Val Ala Thr Trp Leu Thr Leu Pro Val Ala Leu
                  85                  90                  95    
 Leu Glu Thr Met Phe Gly Val Lys Val Ile Ile Thr Gly Asp Ala Phe
             100                 105                 110        
 Val Pro Gly Glu Arg Ser Val Ile Ile Met Asn His Arg Thr Arg Met
         115                 120                 125            
 Asp Trp Met Phe Leu Trp Asn Cys Leu Met Arg Tyr
     130                 135                 140



      <210> 798
      <211> 82
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(82)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 798
 Leu His Ile Glu Lys Ser Asn Glu Ala Ala Asp His Phe Lys His Val
   1               5                  10                  15    
 Ala Cys His Arg Xaa Arg Xaa Ala Cys Thr Cys His Cys Asn Asn Pro
              20                  25                  30        
 Trp Phe Pro Arg Pro Leu Pro Gln Pro Asp Cys Pro Thr Ser Ala Thr
          35                  40                  45            
 Val Glu Pro Pro Leu Tyr Pro Ile Arg Ser Arg Gly Arg Thr Arg Lys
      50                  55                  60                
 Pro Ala Glu Gly Ser Arg Ala Pro Gly Cys Cys Cys Cys Gln Arg Pro
  65                  70                  75                  80
 Gly Lys
        



      <210> 799
      <211> 201
      <212> PRT
      <213> Homo sapiens


      <400> 799
 Ser Cys Asn Trp Phe Gly Lys Gly Lys Arg Gly Phe Ile Met Gly Ile
   1               5                  10                  15    
 Trp Asn Ser His Thr Ser Val Gly Asp Ile Leu Gly Ser Leu Ile Ala
              20                  25                  30        
 Gly Ile Trp Val Asn Gly Gln Trp Gly Leu Ser Phe Ile Val Pro Gly
          35                  40                  45            
 Ile Ile Thr Ala Val Met Gly Val Ile Thr Phe Leu Phe Leu Ile Glu
      50                  55                  60                
 His Pro Glu Asp Val Asp Cys Ala Pro Pro Gln His His Gly Glu Pro
  65                  70                  75                  80
 Ala Glu Asn Gln Asp Asn Pro Glu Asp Pro Gly Asn Ser Pro Cys Ser
                  85                  90                  95    
 Ile Lys Glu Ser Gly Leu Glu Thr Val Ala Lys Cys Ser Lys Gly Pro
             100                 105                 110        
 Cys Glu Glu Pro Ala Ala Ile Ser Phe Phe Gly Ala Leu Arg Ile Pro
         115                 120                 125            
 Gly Val Asp Glu Phe Ser Leu Cys Leu Leu Ile Ala Lys Leu Val Ser
     130                 135                 140                
 Tyr Thr Phe Leu Tyr Trp Leu Pro Leu Tyr Ile Ala Asn Val Ala His
 145                 150                 155                 160
 Phe Ser Ala Lys Glu Ala Gly Asp Leu Ser Thr Leu Phe His Val Gly
                 165                 170                 175    
 Gly Ile Ile Gly Gly Ile Glu Ala Gly Leu Val Ser Asp Tyr Thr Asn
             180                 185                 190        
 Gly Arg Ala Thr Thr Cys Cys Val Met
         195                 200    



      <210> 800
      <211> 145
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(145)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 800
 Arg Pro Leu Ser Leu Ile Asn Ile His Ala Asn Phe Leu Ser Lys Ile
   1               5                  10                  15    
 Leu Ala Asn Ser Ile Lys Gln Cys Leu Asn Arg Ile Ile His His Asp
              20                  25                  30        
 Gly Val Arg Phe Ile Phe Glu Met Xaa Glu Xaa Phe Asn Ile His Arg
          35                  40                  45            
 Ser Ile Asn Val Thr Tyr Tyr Ile Asn Arg Met Lys Asn Lys Asn Met
      50                  55                  60                
 Ile Ile Asp Ala Glu Lys Ala Phe Asp Asn Ile Gln His Pro Phe Ile
  65                  70                  75                  80
 Ile Lys Ile Leu Ile Lys Leu Gly Ile Glu Gly Thr Xaa Leu Asn Thr
                  85                  90                  95    
 Ile Lys Ala Leu Leu Met Ala Ala Ala Ala Cys Leu Asn Ser Cys Cys
             100                 105                 110        
 Lys Asp Ala Arg Ser Ser Arg Gly Gly Met Ala Glu Gly Cys Arg Leu
         115                 120                 125            
 Ser Ala Ser Ser Glu Leu Trp Ala Pro Met Ser Met Gly Gly Gly Leu
     130                 135                 140                
 Arg
 145



      <210> 801
      <211> 91
      <212> PRT
      <213> Homo sapiens


      <400> 801
 Pro Asp His Arg His Gly Ala Leu Trp Trp Trp Tyr Ser Cys Gly Val
   1               5                  10                  15    
 Leu Pro Val Thr Val Ser Arg Asn Glu Gly Asp Glu Arg Asn Gln Val
              20                  25                  30        
 Leu Thr Leu Tyr Leu Trp Ile Arg Gln Glu Trp Thr Asp Ala Tyr Leu
          35                  40                  45            
 Arg Trp Asp Pro Asn Ala Tyr Gly Gly Leu Asp Ala Ile Arg Ile Pro
      50                  55                  60                
 Ser Ser Leu Val Trp Arg Pro Asp Ile Val Leu Tyr Asn Lys Tyr Cys
  65                  70                  75                  80
 Leu Ser Gly Pro Leu Leu Ser Leu Thr Pro Leu
                  85                  90    



      <210> 802
      <211> 117
      <212> PRT
      <213> Homo sapiens


      <400> 802
 Val Gly Glu Arg Leu Thr Leu Pro Gly Leu Val Ser Ala Asp Asn Gly
   1               5                  10                  15    
 Thr Tyr Thr Cys Glu Ala Ser Asn Lys His Gly His Ala Arg Ala Leu
              20                  25                  30        
 Tyr Val Leu Val Val Tyr Asp Pro Gly Ala Val Val Glu Ala Gln Thr
          35                  40                  45            
 Ser Val Pro Tyr Ala Ile Val Gly Gly Ile Leu Ala Leu Leu Val Phe
      50                  55                  60                
 Leu Ile Ile Cys Val Leu Val Gly Met Val Trp Cys Ser Val Arg Gln
  65                  70                  75                  80
 Lys Gly Ser Tyr Leu Thr His Glu Ala Ser Gly Leu Asp Glu Gln Gly
                  85                  90                  95    
 Glu Ala Arg Glu Ala Phe Leu Asn Gly Ser Asp Gly His Lys Arg Lys
             100                 105                 110        
 Glu Glu Phe Phe Ile
         115        



      <210> 803
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 803
 Met Ile Ile Ala Ile Gly Gly Val Ile Val Ala Ser Gly Leu Val Phe
   1               5                  10                  15    
 Ile Val Leu Leu Met Ile Arg Tyr Lys Val Tyr Gly Asp Gly Asp Ser
              20                  25                  30        
 Arg Arg Val Lys Gly Ser Arg Ala Leu Pro Arg Val Arg His Val Cys
          35                  40                  45            
 Ser Gln Thr Asn Gly Ala Gly Thr Gly Ala Glu Gln Ala Pro Ala Leu
      50                  55                  60                
 Pro Ala Gln Asp His Tyr
  65                  70



      <210> 804
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 804
 Gly Arg Ser Leu Lys Pro Gly Pro Pro Pro Ser Ser Gly Pro Gly Gln
   1               5                  10                  15    
 Gln Ala Gly Arg Gly Gln Val Arg Ala Pro Thr Met Arg Gly Glu Leu
              20                  25                  30        
 Trp Leu Leu Val Leu Val Leu Arg Glu Ala Ala Arg Ala Leu Ser Pro
          35                  40                  45            
 Gln Pro Gly Ala Gly His Asp Glu Gly Pro Gly Ser Gly Trp Ala Ala
      50                  55                  60                
 Lys Gly Thr Val Arg Gly Trp Asn Arg Arg Ala Arg Glu Ser Pro Gly
  65                  70                  75                  80
 His Val Ser Glu Pro Asp Arg Thr Gln Leu Ser Gln Asp Leu Gly Gly
                  85                  90                  95    
 Gly Thr Leu Ala Met Asp Thr Leu Pro Asp Asn Arg Thr Arg Val Val
             100                 105                 110        
 Glu Asp Asn His Ser Tyr Tyr Val Ser Arg Leu Tyr Gly Pro Ser Glu
         115                 120                 125            
 Pro His Ser Arg Glu Leu Trp Val Asp Val Ala Glu Ala Asn Arg Ser
     130                 135                 140                
 Gln Val Lys Ile His Thr Ile Leu Ser Asn Thr His Arg Gln Ala Ser
 145                 150                 155                 160
 Arg Val Val Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Pro Leu Arg
                 165                 170                 175    
 Gln Ile Thr Ile Ala Thr Gly Gly Phe Ile Phe Met Gly Asp Val Ile
             180                 185                 190        
 His Arg Met Leu Thr Ala Thr Gln Tyr Val Ala Pro Leu Met Ala Asn
         195                 200                 205            
 Phe Asn Pro Gly Tyr Ser Asp Asn Ser Thr Val Val Tyr Phe Asp Asn
     210                 215                 220                
 Gly Thr Val Phe Val Val Gln Trp Asp His Val Tyr Leu Gln Gly Trp
 225                 230                 235                 240
 Glu Asp Lys Gly Ser Phe Thr Phe Gln Ala Ala Leu His His Asp Gly
                 245                 250                 255    
 Arg Ile Val Phe Ala Tyr Lys Glu Ile Pro Met Ser Val Pro Glu Ile
             260                 265                 270        
 Ser Ser Ser Gln His Pro Val Lys Thr Gly Leu Ser Asp Ala Phe Met
         275                 280                 285            
 Ile Leu Asn Pro Ser Pro Asp Val Pro Glu Ser Arg Arg Arg Ser Ile
     290                 295                 300                
 Phe Glu Tyr His Arg Ile Glu Leu Asp Pro Ser Lys Val Thr Ser Met
 305                 310                 315                 320
 Ser Ala Val Glu Phe Thr Pro Leu Pro Thr Cys Leu Gln His Arg Ser
                 325                 330                 335    
 Cys Asp Ala Cys Met Ser Ser Asp Leu Thr Phe Asn Cys Ser Trp Cys
             340                 345                 350        
 His Val Leu Gln Arg Cys Ser Ser Gly Phe Asp Arg Tyr Arg Gln Glu
         355                 360                 365            
 Trp Met Asp Tyr Gly Cys Ala Gln Glu Ala Glu Gly Arg Met Cys Glu
     370                 375                 380                
 Asp Phe Gln Asp Glu Asp His Asp Ser Ala Ser Pro Asp Thr Ser Phe
 385                 390                 395                 400
 Ser Pro Tyr Asp Gly Asp Leu Thr Thr Thr Ser Ser Ser Leu Phe Ile
                 405                 410                 415    
 Asp Ser Leu Thr Thr Glu Asp Asp Thr Lys Leu Asn Pro Tyr Ala Gly
             420                 425                 430        
 Gly Asp Gly Leu Gln Asn Asn Leu Ser Pro Lys Thr Lys Gly Thr Pro
         435                 440                 445            
 Val His Leu Gly Thr Ile Val Gly Ile Val Leu Ala Val Leu Leu Val
     450                 455                 460                
 Ala Ala Ile Ile Leu Ala Gly Ile Tyr Ile Asn Gly His Pro Thr Ser
 465                 470                 475                 480
 Asn Ala Ala Leu Phe Phe Ile Glu Arg Arg Pro His His Trp Pro Ala
                 485                 490                 495    
 Met Lys Phe Arg Ser His Pro Asp His Ser Thr Tyr Ala Glu Val Glu
             500                 505                 510        
 Pro Ser Gly His Glu Lys Glu Gly Phe Met Glu Ala Glu Gln Cys
         515                 520                 525        



      <210> 805
      <211> 527
      <212> PRT
      <213> Homo sapiens


      <400> 805
 Gly Arg Ser Leu Lys Pro Gly Pro Pro Pro Ser Ser Gly Pro Gly Gln
   1               5                  10                  15    
 Gln Ala Gly Arg Gly Gln Val Arg Ala Pro Thr Met Arg Gly Glu Leu
              20                  25                  30        
 Trp Leu Leu Val Leu Val Leu Arg Glu Ala Ala Arg Ala Leu Ser Pro
          35                  40                  45            
 Gln Pro Gly Ala Gly His Asp Glu Gly Pro Gly Ser Gly Trp Ala Ala
      50                  55                  60                
 Lys Gly Thr Val Arg Gly Trp Asn Arg Arg Ala Arg Glu Ser Pro Gly
  65                  70                  75                  80
 His Val Ser Glu Pro Asp Arg Thr Gln Leu Ser Gln Asp Leu Gly Gly
                  85                  90                  95    
 Gly Thr Leu Ala Met Asp Thr Leu Pro Asp Asn Arg Thr Arg Val Val
             100                 105                 110        
 Glu Asp Asn His Ser Tyr Tyr Val Ser Arg Leu Tyr Gly Pro Ser Glu
         115                 120                 125            
 Pro His Ser Arg Glu Leu Trp Val Asp Val Ala Glu Ala Asn Arg Ser
     130                 135                 140                
 Gln Val Lys Ile His Thr Ile Leu Ser Asn Thr His Arg Gln Ala Ser
 145                 150                 155                 160
 Arg Val Val Leu Ser Phe Asp Phe Pro Phe Tyr Gly His Pro Leu Arg
                 165                 170                 175    
 Gln Ile Thr Ile Ala Thr Gly Gly Phe Ile Phe Met Gly Asp Val Ile
             180                 185                 190        
 His Arg Met Leu Thr Ala Thr Gln Tyr Val Ala Pro Leu Met Ala Asn
         195                 200                 205            
 Phe Asn Pro Gly Tyr Ser Asp Asn Ser Thr Val Val Tyr Phe Asp Asn
     210                 215                 220                
 Gly Thr Val Phe Val Val Gln Trp Asp His Val Tyr Leu Gln Gly Trp
 225                 230                 235                 240
 Glu Asp Lys Gly Ser Phe Thr Phe Gln Ala Ala Leu His His Asp Gly
                 245                 250                 255    
 Arg Ile Val Phe Ala Tyr Lys Glu Ile Pro Met Ser Val Pro Glu Ile
             260                 265                 270        
 Ser Ser Ser Gln His Pro Val Lys Thr Gly Leu Ser Asp Ala Phe Met
         275                 280                 285            
 Ile Leu Asn Pro Ser Pro Asp Val Pro Glu Ser Arg Arg Arg Ser Ile
     290                 295                 300                
 Phe Glu Tyr His Arg Ile Glu Leu Asp Pro Ser Lys Val Thr Ser Met
 305                 310                 315                 320
 Ser Ala Val Glu Phe Thr Pro Leu Pro Thr Cys Leu Gln His Arg Ser
                 325                 330                 335    
 Cys Asp Ala Cys Met Ser Ser Asp Leu Thr Phe Asn Cys Ser Trp Cys
             340                 345                 350        
 His Val Leu Gln Arg Cys Ser Ser Gly Phe Asp Arg Tyr Arg Gln Glu
         355                 360                 365            
 Trp Met Asp Tyr Gly Cys Ala Gln Glu Ala Glu Gly Arg Met Cys Glu
     370                 375                 380                
 Asp Phe Gln Asp Glu Asp His Asp Ser Ala Ser Pro Asp Thr Ser Phe
 385                 390                 395                 400
 Ser Pro Tyr Asp Gly Asp Leu Thr Thr Thr Ser Ser Ser Leu Phe Ile
                 405                 410                 415    
 Asp Ser Leu Thr Thr Glu Asp Asp Thr Lys Leu Asn Pro Tyr Ala Gly
             420                 425                 430        
 Gly Asp Gly Leu Gln Asn Asn Leu Ser Pro Lys Thr Lys Gly Thr Pro
         435                 440                 445            
 Val His Leu Gly Thr Ile Val Gly Ile Val Leu Ala Val Leu Leu Val
     450                 455                 460                
 Ala Ala Ile Ile Leu Ala Gly Ile Tyr Ile Asn Gly His Pro Thr Ser
 465                 470                 475                 480
 Asn Ala Ala Leu Phe Phe Ile Glu Arg Arg Pro His His Trp Pro Ala
                 485                 490                 495    
 Met Lys Phe Arg Ser His Pro Asp His Ser Thr Tyr Ala Glu Val Glu
             500                 505                 510        
 Pro Ser Gly His Glu Lys Glu Gly Phe Met Glu Ala Glu Gln Cys
         515                 520                 525        



      <210> 806
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 806
 Thr Cys Thr Thr Val Val Val Ile Pro Arg Met Leu Val Asp Phe Leu
   1               5                  10                  15    
 Ser Glu Ser Lys Thr Ile Ser Leu Pro Glu Cys Ala Thr Gln Met Phe
              20                  25                  30        
 Phe Phe Leu Gly Phe Ala Ser Asn Asn Cys Phe Ile Met Ala Ala Met
          35                  40                  45            
 Ser Tyr Asp Arg Tyr Thr Ala Ile His Asn Pro Leu Gln Tyr His Thr
      50                  55                  60                
 Leu Met Thr Arg Lys Ile Cys Leu Gln Met Met Met Ala Ser Trp Met
  65                  70                  75                  80
 Val Gly Phe Leu Phe Ser Leu Cys Ile Ile Val Thr Val Phe Asn Leu
                  85                  90                  95    
 Ser Leu Cys Asp Leu Asn Thr Ile Gln His Tyr Phe Cys Asp Ile Ser
             100                 105                 110        
 Pro Val Val Ser Leu Ala Cys Asn Tyr Thr Phe Tyr His Glu Met Ala
         115                 120                 125            
 Ile Phe Val Leu Ser Ala
     130                



      <210> 807
      <211> 419
      <212> PRT
      <213> Homo sapiens


      <400> 807
 Gly Asp Tyr Leu Gln Ala Arg Ile His Ser Leu Lys Leu Gln Ala Gly
   1               5                  10                  15    
 Ala Val Gly Arg Val Val Asp Tyr Gln Asn Gly Phe Tyr Lys Val Phe
              20                  25                  30        
 Phe Thr Leu Leu Trp Pro Gly Lys Val Lys Val Ser Val Ser Leu Val
          35                  40                  45            
 His Pro Ser Glu Gly Ile Arg Val Leu Gln Arg Leu Gln Glu Asp Lys
      50                  55                  60                
 Pro Asp Arg Val Tyr Phe Lys Ser Leu Phe Arg Ser Gly Arg Ile Ser
  65                  70                  75                  80
 Glu Thr Thr Glu Cys Asn Val Cys Leu Pro Gly Asn Leu Pro Leu Cys
                  85                  90                  95    
 Asn Phe Thr Asp Leu Tyr Thr Gly Glu Pro Trp Phe Cys Phe Lys Pro
             100                 105                 110        
 Lys Lys Leu Pro Cys Ser Ser Arg Ile Thr His Phe Lys Gly Gly Tyr
         115                 120                 125            
 Leu Lys Gly Leu Leu Thr Ala Ala Glu Ser Ala Phe Phe Gln Ser Gly
     130                 135                 140                
 Val Asn Ile Lys Met Pro Val Asn Ser Ser Gly Pro Asp Trp Val Thr
 145                 150                 155                 160
 Val Ile Pro Arg Arg Ile Lys Glu Thr Asn Ser Leu Glu Leu Ser Gln
                 165                 170                 175    
 Gly Ser Gly Thr Phe Pro Ser Gly Tyr Tyr Tyr Lys Asp Gln Trp Arg
             180                 185                 190        
 Pro Arg Lys Phe Lys Met Arg Gln Phe Asn Asp Pro Asp Asn Ile Thr
         195                 200                 205            
 Glu Cys Leu Gln Arg Lys Val Val His Leu Phe Gly Asp Ser Thr Ile
     210                 215                 220                
 Arg Gln Trp Phe Glu Tyr Leu Thr Thr Phe Val Pro Asp Leu Val Glu
 225                 230                 235                 240
 Phe Asn Leu Gly Ser Pro Lys Asn Val Gly Pro Phe Leu Ala Val Asp
                 245                 250                 255    
 Gln Lys His Asn Ile Leu Leu Lys Tyr Arg Cys His Gly Pro Pro Ile
             260                 265                 270        
 Arg Phe Thr Thr Val Phe Ser Asn Glu Leu His Tyr Val Ala Asn Glu
         275                 280                 285            
 Leu Asn Gly Ile Val Gly Gly Lys Asn Thr Val Val Ala Ile Ala Val
     290                 295                 300                
 Trp Ser His Phe Ser Thr Phe Pro Leu Glu Val Tyr Ile Arg Arg Leu
 305                 310                 315                 320
 Arg Asn Ile Arg Arg Ala Val Val Arg Leu Leu Asp Arg Ser Pro Lys
                 325                 330                 335    
 Thr Val Val Val Ile Arg Thr Ala Asn Ala Gln Glu Leu Gly Pro Glu
             340                 345                 350        
 Val Ser Leu Phe Asn Ser Asp Trp Tyr Asn Phe Gln Leu Asp Thr Ile
         355                 360                 365            
 Leu Arg Arg Met Phe Ser Gly Val Gly Val Tyr Leu Val Asp Ala Trp
     370                 375                 380                
 Glu Met Thr Leu Ala His Tyr Leu Pro His Lys Leu His Pro Asp Glu
 385                 390                 395                 400
 Val Ile Val Lys Asn Gln Leu Asp Met Phe Leu Ser Phe Val Cys Pro
                 405                 410                 415    
 Leu Glu Thr
            



      <210> 808
      <211> 442
      <212> PRT
      <213> Homo sapiens


      <400> 808
 Pro Arg Ile Pro Gly Ser Thr Ile Ser Ser Pro Leu Val Leu Val Leu
   1               5                  10                  15    
 Val Val Ala Val Thr Val Arg Ala Ala Leu Phe Arg Ser Ser Leu Ala
              20                  25                  30        
 Glu Phe Ile Ser Glu Arg Val Glu Val Val Ser Pro Leu Ser Ser Trp
          35                  40                  45            
 Lys Arg Val Val Glu Gly Leu Ser Leu Leu Asp Leu Gly Val Ser Pro
      50                  55                  60                
 Tyr Ser Gly Ala Val Phe His Glu Thr Pro Leu Ile Ile Tyr Leu Phe
  65                  70                  75                  80
 His Phe Leu Ile Asp Tyr Ala Glu Leu Val Phe Met Ile Thr Asp Ala
                  85                  90                  95    
 Leu Thr Ala Ile Ala Leu Tyr Phe Ala Ile Gln Asp Phe Asn Lys Val
             100                 105                 110        
 Val Phe Lys Lys Gln Lys Leu Leu Leu Glu Leu Asp Gln Tyr Ala Pro
         115                 120                 125            
 Asp Val Ala Glu Leu Ile Arg Thr Pro Met Glu Met Arg Tyr Ile Pro
     130                 135                 140                
 Leu Lys Val Ala Leu Phe Tyr Leu Leu Asn Pro Tyr Thr Ile Leu Ser
 145                 150                 155                 160
 Cys Val Ala Lys Ser Thr Cys Ala Ile Asn Asn Thr Leu Ile Ala Phe
                 165                 170                 175    
 Phe Ile Leu Thr Thr Ile Lys Gly Ser Ala Phe Leu Ser Ala Ile Phe
             180                 185                 190        
 Leu Ala Leu Ala Thr Tyr Gln Ser Leu Tyr Pro Leu Thr Leu Phe Val
         195                 200                 205            
 Pro Gly Leu Leu Tyr Leu Leu Gln Arg Gln Tyr Ile Pro Val Lys Met
     210                 215                 220                
 Lys Ser Lys Ala Phe Trp Ile Phe Ser Trp Glu Tyr Ala Met Met Tyr
 225                 230                 235                 240
 Val Gly Ser Leu Val Val Ile Ile Cys Leu Ser Phe Phe Leu Leu Ser
                 245                 250                 255    
 Ser Trp Asp Phe Ile Pro Ala Val Tyr Gly Phe Ile Leu Ser Val Pro
             260                 265                 270        
 Asp Leu Thr Pro Asn Ile Gly Leu Phe Trp Tyr Phe Phe Ala Glu Met
         275                 280                 285            
 Phe Glu His Phe Ser Leu Phe Phe Val Cys Val Phe Gln Ile Asn Val
     290                 295                 300                
 Phe Phe Tyr Thr Ile Pro Leu Ala Ile Lys Leu Lys Glu His Pro Ile
 305                 310                 315                 320
 Phe Phe Met Phe Ile Gln Ile Ala Val Ile Ala Ile Phe Lys Ser Tyr
                 325                 330                 335    
 Pro Thr Val Gly Asp Val Ala Leu Tyr Met Ala Phe Phe Pro Val Trp
             340                 345                 350        
 Asn His Leu Tyr Arg Phe Leu Arg Asn Ile Phe Val Leu Thr Cys Ile
         355                 360                 365            
 Ile Ile Val Cys Ser Leu Leu Phe Pro Val Leu Trp His Leu Trp Ile
     370                 375                 380                
 Tyr Ala Gly Ser Ala Asn Ser Asn Phe Phe Tyr Ala Ile Thr Leu Thr
 385                 390                 395                 400
 Phe Asn Val Gly Gln Ile Leu Leu Ile Ser Asp Tyr Phe Tyr Ala Phe
                 405                 410                 415    
 Leu Arg Arg Glu Tyr Tyr Leu Thr His Gly Leu Tyr Leu Thr Ala Lys
             420                 425                 430        
 Asp Gly Thr Glu Ala Met Leu Val Leu Lys
         435                 440        



      <210> 809
      <211> 128
      <212> PRT
      <213> Homo sapiens


      <400> 809
 Met Pro Phe Ala Ser Glu Phe Phe Pro Arg Thr Trp Lys Gln Asn Phe
   1               5                  10                  15    
 Val Leu Ala Cys Ile Ser Phe Phe Thr Gly Ala Cys Ala Phe Leu Ala
              20                  25                  30        
 Leu Val Leu His Ala Leu Glu Ile Lys Ala Leu Arg Met Lys Leu Gly
          35                  40                  45            
 Pro Leu Gln Phe Ser Val Leu Trp Pro Tyr Tyr Val Leu Gly Phe Gly
      50                  55                  60                
 Ile Phe Leu Phe Ile Val Ala Gly Thr Ile Cys Leu Ile Gln Glu Met
  65                  70                  75                  80
 Val Cys Pro Cys Trp His Leu Leu Ser Thr Ser Gln Ser Met Glu Glu
                  85                  90                  95    
 Asp His Gly Ser Leu Tyr Leu Asp Asn Leu Glu Ser Leu Gly Gly Glu
             100                 105                 110        
 Pro Ser Ser Val Gln Lys Glu Thr Gln Val Thr Ala Glu Thr Val Ile
         115                 120                 125            





      <210> 810
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 810
 Met Asn Asn Asn Thr Thr Cys Ile Gln Pro Ser Met Ile Ser Ser Met
   1               5                  10                  15    
 Ala Leu Pro Ile Ile Tyr Ile Leu Leu Cys Ile Val Gly Val Phe Gly
              20                  25                  30        
 Asn Thr Leu Ser Gln Trp Ile Phe Leu Thr Lys Ile Gly Lys Lys Thr
          35                  40                  45            
 Ser Thr His Ile Tyr Leu Ser His Leu Val Thr Ala Asn Leu Leu Val
      50                  55                  60                
 Cys
  65



      <210> 811
      <211> 97
      <212> PRT
      <213> Homo sapiens


      <400> 811
 Ile Gln Leu Ile Cys Ala Trp Asn Pro Ile Thr Lys Leu His Arg Thr
   1               5                  10                  15    
 Lys Leu Leu Arg Lys Ala Val Ser Tyr Gln Cys Leu Phe Phe Leu Ser
              20                  25                  30        
 Phe Cys Val Leu His Leu Ile Phe Phe Asn Val Leu Phe Phe Ser Arg
          35                  40                  45            
 Ala Ile Lys Thr Asn Gln Asp Leu Leu Pro Glu Thr Pro Trp Thr His
      50                  55                  60                
 Ile Phe Tyr Asn Asp Phe Trp Gly Thr Leu Leu Thr His Ser Gly Ser
  65                  70                  75                  80
 His Lys Ser Tyr Arg Pro Leu Cys Thr Leu Ser Phe Arg Leu Asn His
                  85                  90                  95    
 Ala
    



      <210> 812
      <211> 96
      <212> PRT
      <213> Homo sapiens


      <400> 812
 Met Val Ala Leu Val Thr Lys Pro Gly Gln Thr Phe Ala Pro Leu Leu
   1               5                  10                  15    
 Gly Thr Trp Leu Leu Cys Phe Tyr Thr Gly His Asp Leu Phe Gln Gln
              20                  25                  30        
 Ser Leu Ile Thr Pro Val Gly Ser Ala His Pro Trp Pro Glu Pro Pro
          35                  40                  45            
 Ala Pro Ala Pro Ala Gln Ala Pro Thr Leu Arg Gln Gly Cys Phe Tyr
      50                  55                  60                
 Leu Leu Val Leu Val Pro Ile Thr Cys Ala Leu Leu Gln Leu Phe Thr
  65                  70                  75                  80
 Cys Ala Gln Phe Thr Leu His Gly Arg Arg Leu His Met Val Lys Ala
                  85                  90                  95    





      <210> 813
      <211> 420
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(420)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 813
 Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu Tyr
   1               5                  10                  15    
 Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr Asp
              20                  25                  30        
 Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe Thr Cys Asp Ser
          35                  40                  45            
 Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys Ala Trp Arg Glu
      50                  55                  60                
 Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu Ala Leu Glu Ile
  65                  70                  75                  80
 Asn Glu Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr
                  85                  90                  95    
 Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly
             100                 105                 110        
 Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His His Gly Ser Gln
         115                 120                 125            
 Tyr Glu Ala Gln His Ser Val Leu Tyr Leu Pro Leu Gln Thr Arg His
     130                 135                 140                
 Gln Cys Leu Gly Val His Gln Lys Lys Ala Ser Asn Val Cys Gln Lys
 145                 150                 155                 160
 Thr Arg Glu Asp Gln Gly Ser Ser Glu Asn Asp Glu Arg Phe Asn Glu
                 165                 170                 175    
 Gly Val Pro Pro Ser Glu Tyr Val Gln Tyr Pro Xaa Lys Pro Phe Lys
             180                 185                 190        
 Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala
         195                 200                 205            
 Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr
     210                 215                 220                
 Ala Ala Leu Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu
 225                 230                 235                 240
 Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu
                 245                 250                 255    
 Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu
             260                 265                 270        
 Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg
         275                 280                 285            
 Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp
     290                 295                 300                
 Lys Arg Val Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly
 305                 310                 315                 320
 Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr
                 325                 330                 335    
 Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser
             340                 345                 350        
 Phe His Glu Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile
         355                 360                 365            
 Leu Phe Thr Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu
     370                 375                 380                
 Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Val Ser
 385                 390                 395                 400
 Val Cys Leu Glu Gly Gly Leu Gly Glu Trp Met Gly Lys Ala Lys Gly
                 405                 410                 415    
 Ile Lys Ala Ala
             420



      <210> 814
      <211> 420
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(420)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 814
 Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu Tyr
   1               5                  10                  15    
 Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr Asp
              20                  25                  30        
 Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe Thr Cys Asp Ser
          35                  40                  45            
 Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys Ala Trp Arg Glu
      50                  55                  60                
 Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu Ala Leu Glu Ile
  65                  70                  75                  80
 Asn Glu Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr
                  85                  90                  95    
 Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly
             100                 105                 110        
 Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His His Gly Ser Gln
         115                 120                 125            
 Tyr Glu Ala Gln His Ser Val Leu Tyr Leu Pro Leu Gln Thr Arg His
     130                 135                 140                
 Gln Cys Leu Gly Val His Gln Lys Lys Ala Ser Asn Val Cys Gln Lys
 145                 150                 155                 160
 Thr Arg Glu Asp Gln Gly Ser Ser Glu Asn Asp Glu Arg Phe Asn Glu
                 165                 170                 175    
 Gly Val Pro Pro Ser Glu Tyr Val Gln Tyr Pro Xaa Lys Pro Phe Lys
             180                 185                 190        
 Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala
         195                 200                 205            
 Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr
     210                 215                 220                
 Ala Ala Leu Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu
 225                 230                 235                 240
 Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu
                 245                 250                 255    
 Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu
             260                 265                 270        
 Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg
         275                 280                 285            
 Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp
     290                 295                 300                
 Lys Arg Val Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly
 305                 310                 315                 320
 Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr
                 325                 330                 335    
 Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser
             340                 345                 350        
 Phe His Glu Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile
         355                 360                 365            
 Leu Phe Thr Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu
     370                 375                 380                
 Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Val Ser
 385                 390                 395                 400
 Val Cys Leu Glu Gly Gly Leu Gly Glu Trp Met Gly Lys Ala Lys Gly
                 405                 410                 415    
 Ile Lys Ala Ala
             420



      <210> 815
      <211> 420
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(420)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 815
 Cys Lys Val Trp Arg Asn Pro Leu Asn Leu Phe Arg Gly Ala Glu Tyr
   1               5                  10                  15    
 Asn Arg Tyr Thr Trp Val Thr Gly Arg Glu Pro Leu Thr Tyr Tyr Asp
              20                  25                  30        
 Met Asn Leu Ser Ala Gln Asp His Gln Thr Phe Phe Thr Cys Asp Ser
          35                  40                  45            
 Asp His Leu Arg Pro Ala Asp Ala Ile Met Gln Lys Ala Trp Arg Glu
      50                  55                  60                
 Arg Asn Pro Gln Ala Arg Ile Ser Ala Ala His Glu Ala Leu Glu Ile
  65                  70                  75                  80
 Asn Glu Cys Ala Thr Ala Tyr Ile Leu Leu Ala Glu Glu Glu Ala Thr
                  85                  90                  95    
 Thr Ile Ala Glu Ala Glu Lys Leu Phe Lys Gln Ala Leu Lys Ala Gly
             100                 105                 110        
 Asp Gly Cys Tyr Arg Arg Ser Gln Gln Leu Gln His His Gly Ser Gln
         115                 120                 125            
 Tyr Glu Ala Gln His Ser Val Leu Tyr Leu Pro Leu Gln Thr Arg His
     130                 135                 140                
 Gln Cys Leu Gly Val His Gln Lys Lys Ala Ser Asn Val Cys Gln Lys
 145                 150                 155                 160
 Thr Arg Glu Asp Gln Gly Ser Ser Glu Asn Asp Glu Arg Phe Asn Glu
                 165                 170                 175    
 Gly Val Pro Pro Ser Glu Tyr Val Gln Tyr Pro Xaa Lys Pro Phe Lys
             180                 185                 190        
 Ala Leu Leu Glu Leu Gln Ala Tyr Ala Asp Val Gln Ala Val Leu Ala
         195                 200                 205            
 Lys Tyr Asp Asp Ile Ser Leu Pro Lys Ser Ala Thr Ile Cys Tyr Thr
     210                 215                 220                
 Ala Ala Leu Leu Lys Ala Arg Ala Val Ser Asp Lys Phe Ser Pro Glu
 225                 230                 235                 240
 Ala Ala Ser Arg Arg Gly Leu Ser Thr Ala Glu Met Asn Ala Val Glu
                 245                 250                 255    
 Ala Ile His Arg Ala Val Glu Phe Asn Pro His Val Pro Lys Tyr Leu
             260                 265                 270        
 Leu Glu Met Lys Ser Leu Ile Leu Pro Pro Glu His Ile Leu Lys Arg
         275                 280                 285            
 Gly Asp Ser Glu Ala Ile Ala Tyr Ala Phe Phe His Leu Ala His Trp
     290                 295                 300                
 Lys Arg Val Glu Gly Ala Leu Asn Leu Leu His Cys Thr Trp Glu Gly
 305                 310                 315                 320
 Thr Phe Arg Met Ile Pro Tyr Pro Leu Glu Lys Gly His Leu Phe Tyr
                 325                 330                 335    
 Pro Tyr Pro Ile Cys Thr Glu Thr Ala Asp Arg Glu Leu Leu Pro Ser
             340                 345                 350        
 Phe His Glu Val Ser Val Tyr Pro Lys Lys Glu Leu Pro Phe Phe Ile
         355                 360                 365            
 Leu Phe Thr Ala Gly Leu Cys Ser Phe Thr Ala Met Leu Ala Leu Leu
     370                 375                 380                
 Thr His Gln Phe Pro Glu Leu Met Gly Val Phe Ala Lys Ala Val Ser
 385                 390                 395                 400
 Val Cys Leu Glu Gly Gly Leu Gly Glu Trp Met Gly Lys Ala Lys Gly
                 405                 410                 415    
 Ile Lys Ala Ala
             420



      <210> 816
      <211> 377
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(377)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 816
 Ala Pro Val Ala Arg Met Thr Ala Pro Leu Phe Tyr Thr Ala Leu Leu
   1               5                  10                  15    
 Val Phe Ser Ala Leu Gly Asn Ile Leu Ala Leu Cys Leu Thr Cys Gln
              20                  25                  30        
 Lys Arg Arg Lys Ile Asn Cys Thr Gly Ile Tyr Leu Val His Leu Ala
          35                  40                  45            
 Val Ser Asp Leu Leu Phe Thr Val Ala Leu Pro Gly Arg Val Val Cys
      50                  55                  60                
 Tyr Val Leu Gly Ser Ser Trp Pro Phe Gly Lys Gly Leu Cys Arg Leu
  65                  70                  75                  80
 Thr Ala Phe Val Leu Tyr Thr Asp Thr Tyr Gly Gly Val Tyr Leu Met
                  85                  90                  95    
 Ala Cys Val Ser Val Asp His Tyr Pro Thr Val Val Cys Ala His Trp
             100                 105                 110        
 Gly Pro Cys Leu Arg Thr Ala Gly Arg Ala Arg Leu Val Cys Val Ala
         115                 120                 125            
 Ile Trp Thr Leu Val Leu Leu Gln Thr Met Pro Leu Leu Leu Met Pro
     130                 135                 140                
 Met Thr Lys Pro Leu Val Gly Lys Leu Ala Cys Met Glu Tyr Ser Ser
 145                 150                 155                 160
 Met Glu Ser Val Leu Gly Leu Pro Leu Met Val Leu Val Ala Phe Ala
                 165                 170                 175    
 Ile Gly Phe Cys Gly Pro Val Gly Ile Ile Leu Ser Cys Tyr Met Lys
             180                 185                 190        
 Ile Thr Trp Lys Leu Cys Ser Thr Ala Gly Arg Thr Gln Xaa Pro Ala
         195                 200                 205            
 Gly Lys Asp Thr Thr Gly Gly Ala Ser Pro Gly Gly Pro Ser Asp Gln
     210                 215                 220                
 Pro Glu Lys Thr Pro Pro Ala Gly Ala Ala Gln Glu Asp Pro Val Thr
 225                 230                 235                 240
 Pro Arg Glu Arg Thr Pro Pro Ala Gly Gln Pro Glu Arg Thr Gln Xaa
                 245                 250                 255    
 Pro Ala Gly Lys Asp Ala Thr Gly Gly Thr Ala Arg Glu Asp Pro Val
             260                 265                 270        
 Thr Ser Arg Lys Gly Arg His Trp Arg Gly Cys Leu Leu Thr Leu Leu
         275                 280                 285            
 Met Leu Val Ala Val Val Val Cys Phe Ser Pro Tyr His Leu Asn Ile
     290                 295                 300                
 Lys Gln Phe Met Ala Arg Gly Met Leu His Leu Pro Ser Cys Ala Glu
 305                 310                 315                 320
 Arg Arg Ala Phe Leu Leu Ser Leu Gln Ala Thr Val Ala Leu Met Asn
                 325                 330                 335    
 Met Asn Cys Gly Ile Asp Pro Ile Ile Tyr Phe Phe Ala Ser Thr His
             340                 345                 350        
 Tyr Arg Lys Trp Leu Leu Gly Ile Leu Lys Leu Lys Gly Ser Ser Ser
         355                 360                 365            
 Ser Ser Ser Ser Ser Ser Thr Leu Tyr
     370                 375        



      <210> 817
      <211> 52
      <212> PRT
      <213> Homo sapiens


      <400> 817
 Pro Leu Thr Leu Cys Leu Pro Glu Asn Asn Lys Pro Pro Gln Ala Asp
   1               5                  10                  15    
 Ala Val Pro Asp Lys Glu Leu Thr Leu Pro Val Asp Ser Thr Thr Leu
              20                  25                  30        
 Asp Gly Ser Lys Ser Ser Asp Asp Gln Lys Ile Ile Ser Tyr Leu Trp
          35                  40                  45            
 Glu Lys Thr Gln
      50        



      <210> 818
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 818
 Tyr Cys Gly His Ser Ser Glu Lys Ser Lys Asp Asp Ser Asp Lys Val
   1               5                  10                  15    
 Gln Val Phe Ile Glu Asp Leu Arg Asp Val Gln His Asp Gly Ala Lys
              20                  25                  30        
 Leu Ala Ala Pro Gln Ala Leu Arg His Gly Asp Asp Ile Val Ala Gly
          35                  40                  45            
 Ile Pro His Ser His Ala Glu Glu Leu Asp Gly Ala Val Val Lys Gly
      50                  55                  60                
 Ala Asp Ser Val Leu Val Ala Leu Arg Asp Val Gly Leu Ser Pro Trp
  65                  70                  75                  80
 Phe Pro Leu His Asp Leu Leu Arg Ser Pro Ile Gly
                  85                  90        



      <210> 819
      <211> 193
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(193)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 819
 Asn Tyr Ser Ile Ala Leu Gly Ala Gly Ser Leu Leu Leu Val Ile Thr
   1               5                  10                  15    
 Tyr Pro Leu Met Lys Arg Ile Ser Tyr Trp Pro Gln Leu Ala Leu Gly
              20                  25                  30        
 Leu Thr Phe Asn Trp Gly Ala Leu Leu Gly Trp Ser Ala Ile Lys Gly
          35                  40                  45            
 Ser Cys Asp Pro Ser Val Cys Leu Pro Leu Tyr Phe Ser Gly Val Met
      50                  55                  60                
 Trp Thr Leu Ile Tyr Asp Thr Ile Tyr Ala His Gln Asp Lys Arg Asp
  65                  70                  75                  80
 Asp Val Leu Ile Gly Leu Lys Ser Thr Ala Leu Arg Phe Gly Glu Asn
                  85                  90                  95    
 Thr Lys Pro Trp Leu Ser Gly Phe Ser Val Ala Met Leu Gly Ala Leu
             100                 105                 110        
 Ser Leu Val Gly Val Asn Ser Gly Gln Thr Ala Pro Tyr Tyr Ala Ala
         115                 120                 125            
 Leu Gly Ala Val Gly Ala His Leu Thr His Gln Ile Tyr Thr Leu Asp
     130                 135                 140                
 Ile His Arg Pro Glu Asp Cys Trp Asn Lys Phe Ile Ser Asn Arg Thr
 145                 150                 155                 160
 Leu Gly Leu Ile Val Phe Leu Gly Ile Val Leu Gly Asn Leu Trp Lys
                 165                 170                 175    
 Glu Lys Lys Thr Asp Xaa Thr Lys Lys Gly Ile Glu Asn Lys Ile Glu
             180                 185                 190        
 Asn
    



      <210> 820
      <211> 209
      <212> PRT
      <213> Homo sapiens


      <400> 820
 Pro Val Ser Tyr His Pro Arg Met Cys Thr Gly Gly Cys Ala Arg Cys
   1               5                  10                  15    
 Leu Gly Gly Thr Leu Ile Pro Leu Ala Phe Phe Gly Phe Leu Ala Asn
              20                  25                  30        
 Ile Leu Leu Phe Phe Pro Gly Gly Lys Val Ile Asp Asp Asn Asp His
          35                  40                  45            
 Leu Ser Gln Glu Ile Trp Phe Phe Gly Gly Ile Leu Gly Ser Gly Val
      50                  55                  60                
 Leu Met Ile Phe Pro Ala Leu Val Phe Leu Gly Leu Lys Asn Asn Asp
  65                  70                  75                  80
 Cys Cys Gly Cys Cys Gly Asn Glu Gly Cys Gly Lys Arg Phe Ala Met
                  85                  90                  95    
 Phe Thr Ser Thr Ile Phe Ala Val Val Gly Phe Leu Gly Ala Gly Tyr
             100                 105                 110        
 Ser Phe Ile Ile Ser Ala Ile Ser Ile Asn Lys Gly Pro Lys Cys Leu
         115                 120                 125            
 Met Ala Asn Ser Thr Trp Gly Tyr Pro Phe His Asp Gly Asp Tyr Leu
     130                 135                 140                
 Asn Asp Glu Ala Leu Trp Asn Lys Cys Arg Glu Pro Leu Asn Val Val
 145                 150                 155                 160
 Pro Trp Asn Leu Thr Leu Phe Ser Ile Leu Leu Val Val Gly Gly Ile
                 165                 170                 175    
 Gln Met Val Leu Cys Ala Ile Gln Val Val Asn Gly Leu Leu Gly Thr
             180                 185                 190        
 Leu Cys Gly Asp Cys Gln Cys Cys Gly Cys Cys Gly Gly Asp Gly Pro
         195                 200                 205            
 Val
    



      <210> 821
      <211> 527
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(527)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 821
 Gly Gly Phe Thr Xaa Ile His Ser Ala Pro Pro His Xaa Arg Leu Ser
   1               5                  10                  15    
 Lys Ser Pro Gln Pro Gly Lys Thr His Ala Cys Ala His Ala Ser Gly
              20                  25                  30        
 Trp Leu Gln Val Thr Ala Glu Ser Leu Val Gly Pro Leu Gly Thr Val
          35                  40                  45            
 Ala Phe Ser Ala Val Ala Ala Leu Thr Ala Cys Arg Pro Arg Ser Val
      50                  55                  60                
 Thr Ile Gln Pro Leu Leu Gln Ser Ser Gln Asn Gln Ser Phe Asn Ala
  65                  70                  75                  80
 Ser Ser Gly Leu Leu Ser Pro Ser Pro Asp His Gln Asp Leu Gly Arg
                  85                  90                  95    
 Ser Gly Arg Val Asp Arg Ser Pro Phe Cys Leu Thr Asn Tyr Pro Val
             100                 105                 110        
 Thr Arg Glu Asp Met Asp Val Val Ser Val His Phe Gln Pro Leu Asp
         115                 120                 125            
 Arg Val Ser Val Arg Val Cys Ser Asp Thr Pro Ser Val Met Arg Leu
     130                 135                 140                
 Arg Leu Asn Thr Gly Met Asp Ser Gly Gly Ser Leu Thr Ile Ser Leu
 145                 150                 155                 160
 Arg Ala Asn Lys Thr Glu Met Arg Asn Glu Thr Val Val Val Ala Cys
                 165                 170                 175    
 Val Asn Ala Ala Ser Pro Phe Leu Gly Phe Asn Thr Ser Leu Asn Cys
             180                 185                 190        
 Thr Thr Ala Phe Phe Gln Gly Tyr Pro Leu Ser Leu Ser Ala Trp Ser
         195                 200                 205            
 Arg Arg Ala Asn Leu Ile Ile Pro Tyr Pro Glu Thr Asp Asn Trp Tyr
     210                 215                 220                
 Leu Ser Leu Gln Leu Met Cys Pro Glu Asn Ala Glu Asp Cys Glu Gln
 225                 230                 235                 240
 Ala Val Val His Val Glu Thr Thr Leu Tyr Leu Val Pro Cys Leu Asn
                 245                 250                 255    
 Asp Cys Gly Pro Tyr Gly Gln Cys Leu Leu Leu Arg Arg His Ser Tyr
             260                 265                 270        
 Leu Tyr Ala Ser Cys Ser Cys Lys Ala Gly Trp Arg Gly Trp Ser Cys
         275                 280                 285            
 Thr Asp Asn Ser Thr Ala Gln Thr Val Ala Gln Gln Arg Ala Ala Thr
     290                 295                 300                
 Leu Leu Leu Thr Leu Ser Asn Leu Met Phe Leu Ala Pro Ile Ala Val
 305                 310                 315                 320
 Ser Val Arg Arg Phe Phe Leu Val Glu Ala Ser Val Tyr Ala Tyr Thr
                 325                 330                 335    
 Met Phe Phe Ser Thr Phe Tyr His Ala Cys Asp Gln Pro Gly Glu Ala
             340                 345                 350        
 Val Leu Cys Ile Leu Ser Tyr Asp Thr Leu Gln Tyr Cys Asp Phe Leu
         355                 360                 365            
 Gly Ser Gly Ala Ala Ile Trp Val Thr Ile Leu Cys Met Ala Arg Leu
     370                 375                 380                
 Lys Thr Val Leu Lys Tyr Val Leu Phe Leu Leu Gly Thr Leu Val Ile
 385                 390                 395                 400
 Ala Met Ser Leu Gln Leu Asp Arg Arg Gly Met Trp Asn Met Leu Gly
                 405                 410                 415    
 Pro Cys Leu Phe Ala Phe Val Ile Met Ala Ser Met Trp Ala Tyr Arg
             420                 425                 430        
 Cys Gly His Arg Arg Gln Cys Tyr Pro Thr Ser Trp Gln Arg Trp Ala
         435                 440                 445            
 Phe Tyr Leu Leu Pro Gly Val Ser Met Ala Ser Val Gly Ile Ala Ile
     450                 455                 460                
 Tyr Thr Ser Met Met Thr Ser Asp Asn Tyr Tyr Tyr Thr His Ser Ile
 465                 470                 475                 480
 Trp His Ile Leu Leu Ala Gly Ser Ala Ala Leu Leu Leu Pro Pro Pro
                 485                 490                 495    
 Asp Gln Pro Ala Glu Pro Trp Ala Cys Ser Gln Lys Phe Pro Cys His
             500                 505                 510        
 Tyr Gln Ile Cys Lys Asn Asp Arg Glu Glu Leu Tyr Ala Val Thr
         515                 520                 525        



      <210> 822
      <211> 128
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(128)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 822
 Tyr Arg Leu Val Arg Phe Glu Asp Leu Ala Arg Glu Pro Leu Ala Glu
   1               5                  10                  15    
 Ile Arg Ala Leu Tyr Ala Phe Thr Gly Leu Ser Leu Thr Pro Gln Leu
              20                  25                  30        
 Glu Ala Trp Ile His Asn Ile Thr His Gly Ser Gly Pro Gly Ala Arg
          35                  40                  45            
 Arg Glu Ala Phe Lys Thr Ser Ser Arg Asn Ala Leu Asn Val Ser Gln
      50                  55                  60                
 Ala Trp Arg His Ala Leu Pro Phe Ala Lys Ile Arg Arg Val Gln Glu
  65                  70                  75                  80
 Leu Cys Ala Gly Ala Leu Gln Leu Leu Gly Tyr Arg Pro Val Tyr Ser
                  85                  90                  95    
 Glu Asp Glu Gln Arg Asn Leu Ala Leu Asp Leu Val Leu Pro Arg Gly
             100                 105                 110        
 Leu Asn Gly Phe Thr Xaa Ala Ser Ser Thr Ala Ser His Pro Arg Asn
         115                 120                 125            





      <210> 823
      <211> 90
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(90)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 823
 Gly Lys Ile Asn Thr Glu Ser Leu Phe Gly Pro Arg Leu Arg Ala Ala
   1               5                  10                  15    
 Ala Gln Lys His Phe Cys Gly Lys Xaa Pro Arg Ser Gly Arg Arg Ala
              20                  25                  30        
 Gln Leu Pro Phe Arg Arg Arg His Gln Cys Val Glu Gln Ser Pro Ser
          35                  40                  45            
 Phe Arg Glu Gly Pro Ser Arg Ser His Arg Gly Arg Arg Ser Arg Glu
      50                  55                  60                
 Arg Gly Pro Pro Arg Thr Arg Lys Asp Ala His Tyr Cys Gln Arg Arg
  65                  70                  75                  80
 Arg Gly Trp Ser Arg Ser Ser Ala Thr Lys
                  85                  90



      <210> 824
      <211> 90
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(90)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 824
 Gly Lys Ile Asn Thr Glu Ser Leu Phe Gly Pro Arg Leu Arg Ala Ala
   1               5                  10                  15    
 Ala Gln Lys His Phe Cys Gly Lys Xaa Pro Arg Ser Gly Arg Arg Ala
              20                  25                  30        
 Gln Leu Pro Phe Arg Arg Arg His Gln Cys Val Glu Gln Ser Pro Ser
          35                  40                  45            
 Phe Arg Glu Gly Pro Ser Arg Ser His Arg Gly Arg Arg Ser Arg Glu
      50                  55                  60                
 Arg Gly Pro Pro Arg Thr Arg Lys Asp Ala His Tyr Cys Gln Arg Arg
  65                  70                  75                  80
 Arg Gly Trp Ser Arg Ser Ser Ala Thr Lys
                  85                  90



      <210> 825
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 825
 Phe Val Gly Asp Glu Asp Glu Asp Ile Arg Asp Arg Gly Ala Lys Pro
   1               5                  10                  15    
 Val Met Val Tyr Ile His Gly Gly Ser Tyr Met Glu Gly Thr Gly Asn
              20                  25                  30        
 Met Ile Asp Gly Ser Ile Leu Ala Ser Tyr Gly Asn Val Ile Val Ile
          35                  40                  45            
 Thr Leu Asn Tyr Arg Val Gly Val Leu Gly Phe Leu Ser Thr Gly Asp
      50                  55                  60                
 Gln Ala Ala Lys Gly Asn Tyr Gly Leu Leu Asp Gln Ile Gln Ala Leu
  65                  70                  75                  80
 Arg Trp Val Ser Glu Asn Ile Ala Phe Phe Gly Gly Asp Pro Arg Arg
                  85                  90                  95    
 Ile Thr Val Phe Gly Ser Gly Ile Gly Ala Ser Cys Val Ser Leu Leu
             100                 105                 110        
 Thr Leu Ser His His Ser Glu Gly Leu Phe Gln Arg Ala Ile Ile Gln
         115                 120                 125            
 Ser Gly Ser Ala Leu Ser Ser Trp Ala Val Thr Tyr Gln Pro Val Lys
     130                 135                 140                
 Tyr Asn Ser Leu Leu Thr Asp Lys Val Gly Cys Asn Val Leu Ala Pro
 145                 150                 155                 160
 Val Arg Asn Arg
                



      <210> 826
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 826
 Tyr Ile Phe Thr Ile Leu Asn Thr Leu Gln Gly Val Phe Ile Leu Leu
   1               5                  10                  15    
 Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu Ala Leu Arg Lys Arg
              20                  25                  30        
 Phe Cys Arg Ala Gln Ala Pro Ser Ser Thr Ile Ser Leu Ala Thr Asn
          35                  40                  45            
 Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly Ser Asp Thr Ala Arg
      50                  55                  60                





      <210> 827
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 827
 Met Gly Cys Ala Ile Ile Ala Gly Phe Leu His Tyr Leu Phe Leu Ala
   1               5                  10                  15    
 Cys Phe Phe Trp Met Leu Val Glu Ala Val Ile Leu Phe Leu Met Val
              20                  25                  30        
 Arg Asn Leu Lys Val Val Asn Tyr Phe Ser Ser Arg Asn Ile Lys Met
          35                  40                  45            
 Leu His Ile Cys Ala Phe Gly Tyr Gly Leu Pro Met Leu Val Val Val
      50                  55                  60                
 Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr Gly Met His Asn Arg Cys
  65                  70                  75                  80
 Trp Leu Asn Thr Glu Thr Gly Phe Ile Trp Ser Phe Leu Gly Pro Val
                  85                  90                  95    
 Cys Thr Val Ile Val Ile Asn Ser Leu Leu Leu Thr Trp Thr Leu Trp
             100                 105                 110        
 Ile Leu Arg Gln Arg Leu Ser Ser Val Asn Ala Glu Val Ser Thr Leu
         115                 120                 125            
 Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala Phe Ala Gln Leu Phe Ile
     130                 135                 140                
 Leu Gly Cys Ser Trp Val Leu Gly Ile Phe Gln Ile Gly Pro Val Ala
 145                 150                 155                 160
 Gly Val Met Ala Tyr Leu Phe His His His Gln Gln Pro Ala Gly Gly
                 165                 170                 175    
 Leu His Leu Pro His Pro Leu Ser Ala Gln Arg Pro Gly Thr Arg Arg
             180                 185                 190        
 Ile Gln Glu Val Asp His Trp Glu Asp Glu Ala Gln Leu Pro Val Pro
         195                 200                 205            
 Asp Leu Lys Asp Leu Ala Val Leu His Ala Ile Arg Phe Gln Asp Gly
     210                 215                 220                
 Leu Lys Ser Phe Leu Ala Phe Lys Tyr Ala Met Glu Pro Thr Val Gly
 225                 230                 235                 240
 Gly Thr Ser Ser Phe Pro Cys Arg Glu Pro Tyr Pro
                 245                 250        



      <210> 828
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 828
 Met Gly Cys Ala Ile Ile Ala Gly Phe Leu His Tyr Leu Phe Leu Ala
   1               5                  10                  15    
 Cys Phe Phe Trp Met Leu Val Glu Ala Val Ile Leu Phe Leu Met Val
              20                  25                  30        
 Arg Asn Leu Lys Val Val Asn Tyr Phe Ser Ser Arg Asn Ile Lys Met
          35                  40                  45            
 Leu His Ile Cys Ala Phe Gly Tyr Gly Leu Pro Met Leu Val Val Val
      50                  55                  60                
 Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr Gly Met His Asn Arg Cys
  65                  70                  75                  80
 Trp Leu Asn Thr Glu Thr Gly Phe Ile Trp Ser Phe Leu Gly Pro Val
                  85                  90                  95    
 Cys Thr Val Ile Val Ile Asn Ser Leu Leu Leu Thr Trp Thr Leu Trp
             100                 105                 110        
 Ile Leu Arg Gln Arg Leu Ser Ser Val Asn Ala Glu Val Ser Thr Leu
         115                 120                 125            
 Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala Phe Ala Gln Leu Phe Ile
     130                 135                 140                
 Leu Gly Cys Ser Trp Val Leu Gly Ile Phe Gln Ile Gly Pro Val Ala
 145                 150                 155                 160
 Gly Val Met Ala Tyr Leu Phe His His His Gln Gln Pro Ala Gly Gly
                 165                 170                 175    
 Leu His Leu Pro His Pro Leu Ser Ala Gln Arg Pro Gly Thr Arg Arg
             180                 185                 190        
 Ile Gln Glu Val Asp His Trp Glu Asp Glu Ala Gln Leu Pro Val Pro
         195                 200                 205            
 Asp Leu Lys Asp Leu Ala Val Leu His Ala Ile Arg Phe Gln Asp Gly
     210                 215                 220                
 Leu Lys Ser Phe Leu Ala Phe Lys Tyr Ala Met Glu Pro Thr Val Gly
 225                 230                 235                 240
 Gly Thr Ser Ser Phe Pro Cys Arg Glu Pro Tyr Pro
                 245                 250        



      <210> 829
      <211> 624
      <212> PRT
      <213> Homo sapiens


      <400> 829
 Thr Cys Trp Leu Thr Leu Asp Pro Gln Ser Gln Ser Gly Thr Ser Ala
   1               5                  10                  15    
 Lys Ile His Gln Ser Thr Lys Thr Pro Gly Thr Leu Thr Leu Gly Leu
              20                  25                  30        
 Leu Leu Arg Pro Glu Gly Leu Thr Ser Val Leu Glu Leu Gly Pro Glu
          35                  40                  45            
 Ala Asp Gln Pro Glu Ala Ala Lys Phe Arg Gln Phe Trp Gly Ser Arg
      50                  55                  60                
 Ser Glu Leu Arg Arg Phe Gln Asp Gly Ala Ile Arg Glu Ala Val Val
  65                  70                  75                  80
 Trp Glu Ala Ala Ser Met Ser Gln Lys Arg Leu Ile Pro His Gln Val
                  85                  90                  95    
 Val Thr His Leu Leu Ala Leu His Ala Asp Ile Pro Glu Thr Cys Val
             100                 105                 110        
 His Tyr Val Gly Gly Pro Leu Asp Ala Leu Ile Gln Gly Leu Lys Glu
         115                 120                 125            
 Thr Ser Ser Thr Gly Glu Glu Ala Leu Val Ala Ala Val Arg Cys Tyr
     130                 135                 140                
 Asp Asp Leu Ser Arg Leu Leu Trp Gly Leu Glu Gly Leu Pro Leu Thr
 145                 150                 155                 160
 Val Ser Ala Val Gln Gly Ala His Pro Val Leu Arg Tyr Thr Glu Val
                 165                 170                 175    
 Phe Pro Pro Thr Pro Val Arg Pro Ala Phe Ser Phe Tyr Glu Thr Leu
             180                 185                 190        
 Arg Glu Arg Ser Ser Leu Leu Pro Arg Leu Asp Lys Pro Cys Pro Ala
         195                 200                 205            
 Tyr Val Glu Pro Met Thr Val Val Cys His Leu Glu Gly Ser Gly Gln
     210                 215                 220                
 Trp Pro Gln Asp Ala Glu Ala Val Gln Arg Val Arg Ala Ala Phe Gln
 225                 230                 235                 240
 Leu Arg Leu Ala Glu Leu Leu Thr Gln Gln His Gly Leu Gln Cys Arg
                 245                 250                 255    
 Ala Thr Ala Thr His Thr Asp Val Leu Lys Asp Gly Phe Val Phe Arg
             260                 265                 270        
 Ile Arg Val Ala Tyr Gln Arg Glu Pro Gln Ile Leu Lys Glu Val Gln
         275                 280                 285            
 Ser Pro Glu Gly Met Ile Ser Leu Arg Asp Thr Ala Ala Ser Leu Arg
     290                 295                 300                
 Leu Glu Arg Asp Thr Arg Gln Leu Pro Leu Leu Thr Ser Ala Leu His
 305                 310                 315                 320
 Gly Leu Gln Gln Gln His Pro Ala Phe Ser Gly Val Ala Arg Leu Ala
                 325                 330                 335    
 Lys Arg Trp Val Arg Ala Gln Leu Leu Gly Glu Gly Phe Ala Asp Glu
             340                 345                 350        
 Ser Leu Asp Leu Val Ala Ala Ala Leu Phe Leu His Pro Glu Pro Phe
         355                 360                 365            
 Thr Pro Pro Ser Ser Pro Gln Val Gly Phe Leu Arg Phe Leu Phe Leu
     370                 375                 380                
 Val Ser Thr Phe Asp Trp Lys Asn Asn Pro Leu Phe Val Asn Leu Asn
 385                 390                 395                 400
 Asn Glu Leu Thr Val Glu Glu Gln Val Glu Ile Arg Ser Gly Phe Leu
                 405                 410                 415    
 Ala Ala Arg Ala Gln Leu Pro Val Met Val Ile Val Thr Pro Gln Asp
             420                 425                 430        
 Arg Lys Asn Ser Val Trp Thr Gln Asp Gly Pro Ser Ala Gln Ile Leu
         435                 440                 445            
 Gln Gln Leu Val Val Leu Ala Ala Glu Ala Leu Pro Met Leu Glu Lys
     450                 455                 460                
 Gln Leu Met Asp Pro Arg Gly Pro Gly Asp Ile Arg Thr Val Phe Arg
 465                 470                 475                 480
 Pro Pro Leu Asp Ile Tyr Asp Val Leu Ile Arg Leu Ser Pro Arg His
                 485                 490                 495    
 Ile Pro Arg His Arg Gln Ala Val Asp Ser Pro Ala Ala Ser Phe Cys
             500                 505                 510        
 Arg Gly Leu Leu Ser Gln Pro Gly Pro Ser Ser Leu Met Pro Val Leu
         515                 520                 525            
 Gly Tyr Asp Pro Pro Gln Leu Tyr Leu Thr Gln Leu Arg Glu Ala Phe
     530                 535                 540                
 Gly Asp Leu Ala Leu Phe Phe Tyr Asp Gln His Gly Gly Glu Val Ile
 545                 550                 555                 560
 Gly Val Leu Trp Lys Pro Thr Ser Phe Gln Pro Gln Pro Phe Lys Ala
                 565                 570                 575    
 Ser Ser Thr Lys Gly Arg Met Val Met Ser Arg Gly Gly Glu Leu Val
             580                 585                 590        
 Met Val Pro Asn Val Glu Ala Ile Leu Glu Asp Phe Ala Val Leu Gly
         595                 600                 605            
 Glu Gly Leu Val Gln Thr Val Glu Ala Arg Ser Glu Arg Trp Thr Val
     610                 615                 620                





      <210> 830
      <211> 195
      <212> PRT
      <213> Homo sapiens


      <400> 830
 Met Ala Pro Arg Ala Leu Pro Gly Ser Ala Val Leu Ala Ala Ala Val
   1               5                  10                  15    
 Phe Val Gly Gly Ala Val Ser Ser Pro Leu Val Ala Pro Asp Asn Gly
              20                  25                  30        
 Ser Ser Arg Thr Leu His Ser Arg Thr Glu Thr Thr Pro Ser Pro Ser
          35                  40                  45            
 Asn Asp Thr Gly Asn Gly His Pro Glu Tyr Ile Ala Tyr Ala Leu Val
      50                  55                  60                
 Pro Val Phe Phe Ile Met Gly Leu Phe Gly Val Leu Ile Cys His Leu
  65                  70                  75                  80
 Leu Lys Lys Lys Gly Tyr Arg Cys Thr Thr Glu Ala Glu Gln Asp Ile
                  85                  90                  95    
 Glu Glu Glu Lys Val Glu Lys Ile Glu Leu Asn Asp Ser Val Asn Glu
             100                 105                 110        
 Asn Ser Asp Thr Val Gly Gln Ile Val His Tyr Ile Met Lys Asn Glu
         115                 120                 125            
 Ala Asn Ala Asp Val Leu Lys Ala Met Val Ala Asp Asn Ser Leu Tyr
     130                 135                 140                
 Asp Pro Glu Ser Pro Val Thr Pro Ser Thr Pro Gly Glu Pro Ala Ser
 145                 150                 155                 160
 Glu Ser Trp Ala Phe Val Thr Arg Gly Asp Ala Arg Glu Ala Arg Leu
                 165                 170                 175    
 Trp Pro Ser Ser Ala Tyr Gly Gly Arg Cys Cys Arg Glu Gly Cys Val
             180                 185                 190        
 Ser Ser Val
         195



      <210> 831
      <211> 355
      <212> PRT
      <213> Homo sapiens


      <400> 831
 Gln Lys Arg Arg Lys Arg Arg Arg Lys Lys Ile Met Lys Thr Ile Gln
   1               5                  10                  15    
 Pro Lys Met His Asn Ser Ile Ser Trp Ala Ile Phe Thr Gly Leu Ala
              20                  25                  30        
 Ala Leu Cys Leu Phe Gln Gly Val Pro Val Arg Ser Gly Asp Ala Thr
          35                  40                  45            
 Phe Pro Lys Ala Met Asp Asn Val Thr Val Arg Gln Gly Glu Ser Ala
      50                  55                  60                
 Thr Leu Arg Cys Thr Ile Asp Asn Arg Val Thr Arg Val Ala Trp Leu
  65                  70                  75                  80
 Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp Lys Trp Cys Leu Asp
                  85                  90                  95    
 Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr Gln Tyr Ser Ile Glu
             100                 105                 110        
 Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Pro Tyr Thr Cys Ser Val
         115                 120                 125            
 Gln Thr Asp Asn His Pro Lys Thr Ser Arg Val His Leu Ile Val Gln
     130                 135                 140                
 Val Ser Pro Lys Ile Val Glu Ile Ser Ser Asp Ile Ser Ile Asn Glu
 145                 150                 155                 160
 Gly Asn Asn Ile Ser Leu Thr Cys Ile Ala Thr Gly Arg Pro Glu Pro
                 165                 170                 175    
 Thr Val Thr Trp Arg His Ile Ser Pro Lys Ala Val Gly Phe Val Ser
             180                 185                 190        
 Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr Arg Glu Gln Ser Gly
         195                 200                 205            
 Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala Ala Pro Val Val Arg
     210                 215                 220                
 Arg Val Lys Val Thr Val Asn Tyr Pro Pro Tyr Ile Ser Glu Ala Lys
 225                 230                 235                 240
 Gly Thr Gly Val Pro Val Gly Gln Lys Gly Thr Leu Gln Cys Glu Ala
                 245                 250                 255    
 Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr Lys Asp Asp Lys Arg
             260                 265                 270        
 Leu Ile Glu Gly Lys Lys Gly Val Lys Val Glu Asn Arg Pro Phe Leu
         275                 280                 285            
 Ser Lys Leu Ile Phe Phe Asn Val Ser Glu His Asp Tyr Gly Asn Tyr
     290                 295                 300                
 Thr Cys Val Ala Ser Asn Lys Leu Gly His Thr Asn Ala Ser Ile Met
 305                 310                 315                 320
 Leu Phe Gly Pro Gly Ala Val Ser Glu Val Ser Asn Gly Thr Ser Arg
                 325                 330                 335    
 Arg Ala Gly Cys Val Trp Leu Leu Pro Leu Leu Val Leu His Leu Leu
             340                 345                 350        
 Leu Lys Phe
         355



      <210> 832
      <211> 198
      <212> PRT
      <213> Homo sapiens


      <400> 832
 Ala Gly Gly Ser Gln Ala Ala Arg Val Ser Gly Gly Gly Gly Val Arg
   1               5                  10                  15    
 Cys Pro Arg Met Gly Ile Leu Phe Thr Arg Ile Trp Arg Leu Phe Asn
              20                  25                  30        
 His Gln Glu His Lys Val Ile Ile Val Gly Leu Asp Asn Ala Gly Lys
          35                  40                  45            
 Thr Thr Ile Leu Tyr Gln Phe Ser Met Asn Glu Val Val His Thr Ser
      50                  55                  60                
 Pro Thr Ile Gly Ser Asn Val Glu Glu Ile Val Ile Asn Asn Thr Arg
  65                  70                  75                  80
 Phe Leu Met Trp Asp Ile Gly Gly Gln Glu Ser Leu Arg Ser Ser Trp
                  85                  90                  95    
 Asn Thr Tyr Tyr Thr Asn Thr Glu Phe Val Ile Val Val Val Asp Ser
             100                 105                 110        
 Thr Asp Arg Glu Arg Ile Ser Val Thr Arg Glu Glu Leu Tyr Lys Met
         115                 120                 125            
 Leu Ala His Glu Asp Leu Arg Lys Ala Gly Leu Leu Ile Phe Ala Asn
     130                 135                 140                
 Lys Gln Asp Val Lys Glu Cys Met Thr Val Ala Glu Ile Ser Gln Phe
 145                 150                 155                 160
 Leu Lys Leu Thr Ser Ile Lys Asp His Gln Trp His Ile Gln Ala Cys
                 165                 170                 175    
 Cys Ala Leu Thr Gly Glu Gly Leu Cys Gln Gly Leu Glu Trp Met Met
             180                 185                 190        
 Ser Arg Leu Lys Ile Arg
         195            



      <210> 833
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 833
 Met Phe Phe Gly Ser Ala Ala Leu Gly Thr Leu Thr Gly Leu Ile Ser
   1               5                  10                  15    
 Ala Leu Val Leu Lys His Ile Asp Leu Arg Lys Thr Pro Ser Leu Glu
              20                  25                  30        
 Phe Gly Met Met Ile Ile Phe Ala Tyr Leu Pro Tyr Gly Leu Ala Glu
          35                  40                  45            
 Gly Ile Ser Leu Ser Gly Ile Met Ala Ile Leu Phe Ser Gly Ile Val
      50                  55                  60                
 Met Ser His Tyr Thr His His Asn Leu Ser Pro Val Thr Gln Ile Leu
  65                  70                  75                  80
 Met Gln Gln Thr Leu Arg Thr Val Ala Phe Leu Cys Glu Thr Cys Val
                  85                  90                  95    
 Phe Ala Phe Leu Gly Leu Ser Ile Phe Ser Phe Pro His Lys Phe Glu
             100                 105                 110        
 Ile Ser Phe Val Ile Trp Cys Ile Val Leu Val Leu Phe Gly Arg Ala
         115                 120                 125            
 Val Asn Ile Phe Pro Leu Ser Tyr Leu Leu Asn Phe Phe Arg Asp His
     130                 135                 140                
 Lys Ile Thr Pro Lys Met Met Phe Ile Met Trp Phe Ser Gly Leu Arg
 145                 150                 155                 160
 Gly Ala Ile Pro Tyr Ala Leu Ser Leu His Leu Asp Leu Glu Pro Met
                 165                 170                 175    
 Glu Lys Arg Gln Leu Ile Gly Thr Thr Thr Ile Val Ile Val Leu Phe
             180                 185                 190        
 Thr Ile Leu Leu Leu Gly Gly Ser Thr Met Pro Leu Ile Arg Leu Met
         195                 200                 205            
 Asp Ile Glu Asp Ala Lys Ala His Arg Arg Asn Lys Lys Asp Val Asn
     210                 215                 220                
 Leu Ser Lys Thr Glu Lys Met Gly Asn Thr Val Glu Ser Glu His Leu
 225                 230                 235                 240
 Ser Glu Leu Thr Glu Glu Glu Tyr Glu Ala His Tyr Ile Arg Arg Gln
                 245                 250                 255    
 Asp Leu Lys Gly Phe Val Trp Leu Asp Ala Lys Tyr Leu Asn Pro Phe
             260                 265                 270        
 Phe Thr Arg Arg Leu Thr Gln Glu Asp Leu His His Gly Arg Ile Gln
         275                 280                 285            
 Met Lys Thr Leu Thr Asn Lys Trp Tyr Glu Glu Val Arg Gln Gly Pro
     290                 295                 300                
 Ser Gly Ser Glu Asp Asp Glu Gln Glu Leu Leu
 305                 310                 315



      <210> 834
      <211> 370
      <212> PRT
      <213> Homo sapiens


      <400> 834
 Pro Cys Ala Asp Cys Leu Ser Ala Trp Ala Met Val Pro Ala Ala Gly
   1               5                  10                  15    
 Arg Arg Pro Pro Arg Val Met Arg Leu Leu Gly Trp Trp Gln Val Leu
              20                  25                  30        
 Leu Trp Val Leu Gly Leu Pro Val Arg Gly Val Glu Val Ala Glu Glu
          35                  40                  45            
 Ser Gly Arg Leu Trp Ser Glu Glu Gln Pro Ala His Pro Leu Gln Val
      50                  55                  60                
 Gly Ala Val Tyr Leu Gly Glu Glu Glu Leu Leu His Asp Pro Met Gly
  65                  70                  75                  80
 Gln Asp Arg Ala Ala Glu Glu Ala Asn Ala Val Leu Gly Leu Asp Thr
                  85                  90                  95    
 Gln Gly Asp His Met Val Met Leu Ser Val Ile Pro Gly Glu Ala Glu
             100                 105                 110        
 Asp Lys Val Ser Ser Glu Pro Ser Gly Val Thr Cys Gly Ala Gly Gly
         115                 120                 125            
 Ala Glu Asp Ser Arg Cys Asn Val Arg Glu Ser Leu Phe Ser Leu Asp
     130                 135                 140                
 Gly Ala Gly Ala His Phe Pro Asp Arg Glu Glu Glu Tyr Tyr Thr Glu
 145                 150                 155                 160
 Pro Glu Val Ala Glu Ser Asp Ala Ala Pro Thr Glu Asp Ser Asn Asn
                 165                 170                 175    
 Thr Glu Ser Leu Lys Ser Pro Lys Val Asn Cys Glu Glu Arg Asn Ile
             180                 185                 190        
 Thr Gly Leu Glu Asn Phe Thr Leu Lys Ile Leu Asn Met Ser Gln Asp
         195                 200                 205            
 Leu Met Asp Phe Leu Asn Pro Asn Gly Ser Asp Cys Thr Leu Val Leu
     210                 215                 220                
 Phe Tyr Thr Pro Trp Cys Arg Phe Ser Ala Ser Leu Ala Pro His Phe
 225                 230                 235                 240
 Asn Ser Leu Pro Arg Ala Phe Pro Ala Leu His Phe Leu Ala Leu Asp
                 245                 250                 255    
 Ala Ser Gln His Ser Ser Leu Ser Thr Arg Phe Gly Thr Val Ala Val
             260                 265                 270        
 Pro Asn Ile Leu Leu Phe Gln Gly Ala Lys Pro Met Ala Arg Phe Asn
         275                 280                 285            
 His Thr Asp Arg Thr Leu Glu Thr Leu Lys Ile Phe Ile Phe Asn Gln
     290                 295                 300                
 Thr Gly Ile Glu Ala Lys Lys Asn Val Val Val Thr Gln Ala Asp Gln
 305                 310                 315                 320
 Ile Gly Pro Leu Pro Ser Thr Leu Ile Lys Ser Val Asp Trp Leu Leu
                 325                 330                 335    
 Val Phe Ser Leu Phe Phe Leu Ile Ser Phe Ile Met Tyr Ala Thr Ile
             340                 345                 350        
 Arg Thr Glu Ser Ile Arg Trp Leu Ile Pro Gly Gln Glu Gln Glu His
         355                 360                 365            
 Val Glu
     370



      <210> 835
      <211> 262
      <212> PRT
      <213> Homo sapiens


      <400> 835
 Phe Ala Thr Arg Phe Asn Ala Gly Pro Ile Asp Thr Thr Ile Ile Met
   1               5                  10                  15    
 Asn Gly Arg Gln Ile Gln Cys Leu Gly Thr His Val Tyr Arg Gly Pro
              20                  25                  30        
 Glu Glu Glu Gly Asp Met Leu Asp Pro Gly Leu Val Met Thr Gly Thr
          35                  40                  45            
 Lys Cys Gly Tyr Asn His Ile Cys Phe Glu Gly Gln Cys Arg Asn Thr
      50                  55                  60                
 Ser Phe Phe Glu Thr Glu Gly Cys Gly Lys Lys Cys Asn Gly His Gly
  65                  70                  75                  80
 Val Cys Asn Asn Asn Gln Asn Cys His Cys Leu Pro Gly Trp Ala Pro
                  85                  90                  95    
 Pro Phe Cys Asn Thr Pro Gly His Gly Gly Ser Ile Asp Ser Gly Pro
             100                 105                 110        
 Met Pro Pro Glu Ser Val Gly Pro Val Val Ala Gly Val Leu Val Ala
         115                 120                 125            
 Ile Leu Val Leu Ala Val Leu Met Leu Met Tyr Tyr Cys Cys Arg Gln
     130                 135                 140                
 Asn Asn Lys Leu Gly Gln Leu Lys Pro Ser Ala Leu Pro Ser Lys Leu
 145                 150                 155                 160
 Arg Gln Gln Phe Ser Cys Pro Phe Arg Val Ser Gln Asn Ser Gly Thr
                 165                 170                 175    
 Gly His Ala Asn Pro Thr Phe Lys Leu Gln Thr Pro Gln Gly Lys Arg
             180                 185                 190        
 Lys Val Ile Asn Thr Pro Glu Ile Leu Arg Lys Pro Ser Gln Pro Pro
         195                 200                 205            
 Pro Arg Pro Pro Pro Asp Tyr Leu Arg Gly Gly Ser Pro Pro Ala Pro
     210                 215                 220                
 Leu Pro Ala His Leu Ser Arg Ala Ala Arg Asn Ser Pro Gly Pro Gly
 225                 230                 235                 240
 Ser Gln Ile Glu Arg Thr Glu Ser Ser Arg Arg Pro Pro Pro Ser Arg
                 245                 250                 255    
 Pro Ile Pro Pro Ala Pro
             260        



      <210> 836
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 836
 His Ala Ser Gly Phe Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly
   1               5                  10                  15    
 Asp Leu Asn Thr Val Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp
              20                  25                  30        
 Ala Leu Tyr Leu Ser Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu
          35                  40                  45            
 Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu
      50                  55                  60                
 Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala
  65                  70                  75                  80
 Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile
                  85                  90                  95    
 Val Ser Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala Lys Pro Val Phe
             100                 105                 110        
 Glu Gly Asp Leu Leu Val Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro
         115                 120                 125            
 Leu Thr Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro
     130                 135                 140                
 Gly Pro Asn Arg Glu Phe Phe His Pro Pro Val Gly Asn Lys Arg Ala
 145                 150                 155                 160
 Asp Lys Pro Gly Asn
                 165



      <210> 837
      <211> 165
      <212> PRT
      <213> Homo sapiens


      <400> 837
 His Ala Ser Gly Phe Met Leu Lys Lys Ile Ser Val Gly Val Ala Gly
   1               5                  10                  15    
 Asp Leu Asn Thr Val Thr Met Lys Leu Gly Cys Val Leu Met Ala Trp
              20                  25                  30        
 Ala Leu Tyr Leu Ser Leu Gly Val Leu Trp Val Ala Gln Met Leu Leu
          35                  40                  45            
 Ala Ala Ser Phe Glu Thr Leu Gln Cys Glu Gly Pro Val Cys Thr Glu
      50                  55                  60                
 Glu Ser Ser Cys His Thr Glu Asp Asp Leu Thr Asp Ala Arg Glu Ala
  65                  70                  75                  80
 Gly Phe Gln Val Lys Ala Tyr Thr Phe Ser Glu Pro Phe His Leu Ile
                  85                  90                  95    
 Val Ser Tyr Asp Trp Leu Ile Leu Gln Gly Pro Ala Lys Pro Val Phe
             100                 105                 110        
 Glu Gly Asp Leu Leu Val Leu Arg Cys Gln Ala Trp Gln Asp Trp Pro
         115                 120                 125            
 Leu Thr Gln Val Thr Phe Tyr Arg Asp Gly Ser Ala Leu Gly Pro Pro
     130                 135                 140                
 Gly Pro Asn Arg Glu Phe Phe His Pro Pro Val Gly Asn Lys Arg Ala
 145                 150                 155                 160
 Asp Lys Pro Gly Asn
                 165



      <210> 838
      <211> 179
      <212> PRT
      <213> Homo sapiens


      <400> 838
 Lys Tyr Lys Lys Cys Ser Leu Gln Lys Asn Leu Leu Leu Val Gly Cys
   1               5                  10                  15    
 Lys Lys Tyr Ser Leu Cys Tyr Arg Arg His Lys Leu His Leu Val Thr
              20                  25                  30        
 His Gly Glu Arg Lys Lys Pro Ala Ala Val Asn Ser Phe Phe Leu Phe
          35                  40                  45            
 Phe Ser Phe Phe Phe Phe Leu Asn Leu Val Arg Asn Thr Glu Ile Thr
      50                  55                  60                
 Lys Lys Arg Val Asn Leu His Glu Thr Lys Ala Asp Ala Glu Ser Cys
  65                  70                  75                  80
 Asn Gln Asp Cys Thr Thr Ser Ser Glu Thr Ala Ser Glu Leu Glu Gln
                  85                  90                  95    
 Ile Arg Ser Gly Lys His Asn Ser Gly Lys Trp Ala Gly Glu Gly Ala
             100                 105                 110        
 Ala Gly Gly Arg Arg Glu Gly Glu Arg Met Glu Trp Thr Glu Met Arg
         115                 120                 125            
 Arg Gly Ala Arg Gly Arg Arg Gly Gly Arg Glu Arg Glu Met Glu Arg
     130                 135                 140                
 Ala Arg Val Arg Gly Gly Glu Glu Arg Glu Lys Glu Ile Asp Leu Tyr
 145                 150                 155                 160
 Lys Lys Val Thr Ser Lys Ile Glu Glu Thr Lys Leu Gly Asn Leu Leu
                 165                 170                 175    
 Lys Leu Gly
            



      <210> 839
      <211> 581
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(581)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 839
 Ser Trp Phe Gly Xaa Glu Gln Gly Xaa Gly Arg Asp Gly Ala Glu Lys
   1               5                  10                  15    
 Gly Gln Gly Val Gln Pro Gln Val Ala Gln Ser Asn Thr Glu Glu Gln
              20                  25                  30        
 Gly Leu Ala Phe Lys Ser Ala Gly Pro Trp Gly Glu Gln Met Val Pro
          35                  40                  45            
 Gly Val Pro His Gly Gly Thr Gly Gly Gly Ala Leu Gly Gly Arg Gln
      50                  55                  60                
 His Pro Arg Arg Ser Gly Thr Pro Ala Glu Ala Asp Pro Asn Phe Lys
  65                  70                  75                  80
 Ala Ala Lys Phe Xaa Trp Glu Cys Pro Pro Pro Gly Thr Ser Pro Ser
                  85                  90                  95    
 Pro Gly Arg Ala Glu Pro Trp Arg Ser Gly Thr Pro Ala Leu Arg Leu
             100                 105                 110        
 Thr Pro Val Leu Gly Leu Pro Gly Ser Asp Gly Ser Val Leu Gln Glu
         115                 120                 125            
 Cys Leu Gln Ala Pro Ser Gly Gln Ser Pro Glu Gly Ser Glu Gly Met
     130                 135                 140                
 Met Gly Ile Ser Gly Ile Leu Val Val Pro Gly Val Glu Gln Gly His
 145                 150                 155                 160
 Pro Xaa Ala Lys Ala Ala Gly Val Gly Ala Met Leu Pro Pro Ser Pro
                 165                 170                 175    
 Trp Gly Arg Gly Gly Gly Gly Gly Leu Cys Ile Arg Pro Gly Gln Ile
             180                 185                 190        
 Pro Gly Lys Pro Gly Pro Ala Ala Gly Arg Gly Val Ser Pro Gly Ala
         195                 200                 205            
 Ser Gly Asp Ala Pro Arg Ser Thr Asp Arg Arg Gly Ala Ala Ala Gly
     210                 215                 220                
 Pro Ala Arg Ser Pro Gly Pro Pro Tyr Leu Gln Phe Ser Ser Gly Thr
 225                 230                 235                 240
 Leu Cys Leu Gly Arg Cys Thr Trp Gln Ala Gly Gly Cys Gly Pro Ala
                 245                 250                 255    
 Pro Pro Ser Pro Ser Gly Cys Cys Phe Cys Asn Leu Ala Gly Cys Pro
             260                 265                 270        
 His Ser Cys Lys Ala Ser Gly Pro Leu Gln Pro Gln Arg Thr Pro Pro
         275                 280                 285            
 Ser Xaa His Pro Ser Pro Leu Thr Phe Pro Thr Ser Gly Pro Ser Ile
     290                 295                 300                
 Arg Ser Leu Arg Gly Ala Cys Gly Arg Pro Gly Gly Gln Xaa Pro Val
 305                 310                 315                 320
 Ala Gly Xaa Arg Ala Ala Ala Trp Pro Ala Arg Ser Pro Ala Ala Gly
                 325                 330                 335    
 Arg Ser Gly Leu Gly Ser Arg Gly Arg Xaa His Xaa Xaa Arg Cys Glu
             340                 345                 350        
 Pro Arg Ala Ser Val Gly Ser Gly Pro Gly Ala Pro Arg Gly Trp Ser
         355                 360                 365            
 Arg Cys Pro Glu Ser Pro Gly Gly Ala Ala Pro Arg Gly Val Arg Arg
     370                 375                 380                
 Pro Ser Gly Gly Arg Arg Gly Val Arg Ala Gly His Ser Asn Gly Gly
 385                 390                 395                 400
 Ala Gly Gly Arg Ser Arg Cys Pro Arg Arg Arg Pro Pro Ala Ala Arg
                 405                 410                 415    
 Tyr Ala Val Arg Ser His Arg Ala Gln Arg His Pro Arg Pro Gln Pro
             420                 425                 430        
 Arg Gly Arg Ala Glu Lys Gly Ala Arg Arg Arg Gly Ala Arg Pro Thr
         435                 440                 445            
 Arg Arg Gly Pro Ala Gly Gly Pro Arg Gly Arg Ala Gly Pro Arg Ala
     450                 455                 460                
 Ala Ala Gly Pro Ser Ala Pro Pro Val Glu Pro Pro Pro Arg Ala Gly
 465                 470                 475                 480
 Arg Ser Thr Arg Ala Arg Gly Ser Arg Arg Ser Glu Ala Arg Val Arg
                 485                 490                 495    
 Arg Ala Pro Pro Pro Ala Pro Pro Ser Arg Arg Pro Ser Ser Arg Gly
             500                 505                 510        
 Trp Pro Gly Leu Arg Arg Gly Arg Gly Gln Arg Arg Ala Gly Arg Gly
         515                 520                 525            
 Gly Gly Arg Gly Ser Arg Gly Gly Ser Trp Gly Ala Gly Gly Lys Pro
     530                 535                 540                
 His Gly Arg Arg Xaa Pro Pro Gly Gly Arg Pro Gly Ser Arg Arg Gly
 545                 550                 555                 560
 Gly Ser Ser Asp Gly Ala Gly Cys Arg Cys Thr Ala Pro Arg Pro Ser
                 565                 570                 575    
 Pro Pro Pro Arg Gly
             580    



      <210> 840
      <211> 106
      <212> PRT
      <213> Homo sapiens


      <400> 840
 Met Ala Leu Tyr Glu Leu Phe Ser His Pro Val Glu Arg Ser Tyr Arg
   1               5                  10                  15    
 Ala Gly Leu Cys Ser Lys Ala Ala Leu Phe Leu Leu Leu Ala Ala Ala
              20                  25                  30        
 Leu Thr Tyr Ile Pro Pro Leu Leu Val Ala Phe Arg Ser His Gly Phe
          35                  40                  45            
 Trp Leu Lys Arg Ser Ser Tyr Glu Glu Gln Pro Thr Val Arg Phe Gln
      50                  55                  60                
 His Gln Val Leu Leu Val Ala Leu Leu Gly Pro Glu Ser Asp Gly Phe
  65                  70                  75                  80
 Leu Ala Trp Ser Thr Phe Pro Ala Phe Asn Arg Gln Gln Gly Asp Arg
                  85                  90                  95    
 Leu Arg Val Pro Leu Val Ser Trp Arg Arg
             100                 105    



      <210> 841
      <211> 191
      <212> PRT
      <213> Homo sapiens


      <400> 841
 Leu Gly Thr Arg Ile Tyr Asp Ile Tyr Ala Met Phe Leu Cys His Trp
   1               5                  10                  15    
 His Lys His Gln Val Lys Gly His Gly Gly Asp Asp Gly Ala Ala Arg
              20                  25                  30        
 Ala Pro Gly Ser Thr Trp Ala Ile Ala Arg Gly Tyr Leu His Lys Glu
          35                  40                  45            
 Phe Leu Met Val Leu His His Ala Ala Met Val Leu Val Cys Phe Pro
      50                  55                  60                
 Leu Ser Val Val Trp Arg Gln Gly Lys Gly Asp Phe Phe Leu Gly Cys
  65                  70                  75                  80
 Met Leu Met Ala Glu Val Ser Thr Pro Phe Val Cys Leu Gly Lys Ile
                  85                  90                  95    
 Leu Ile Gln Tyr Lys Gln Gln His Thr Leu Leu His Lys Val Asn Gly
             100                 105                 110        
 Ala Leu Met Leu Leu Ser Phe Leu Cys Cys Arg Val Leu Leu Phe Pro
         115                 120                 125            
 Tyr Leu Tyr Trp Ala Tyr Gly Ala Met Pro Ala Cys Pro Cys Trp Pro
     130                 135                 140                
 Cys Pro Trp Pro Leu Pro Ala His Val Asn Leu Gly Ala Ala Leu Leu
 145                 150                 155                 160
 Leu Ala Pro Gln Leu Tyr Trp Val Phe Leu Ile Cys Arg Gly Ala Cys
                 165                 170                 175    
 Arg Leu Phe Trp Pro Arg Ser Arg Thr Pro Thr Asp Trp Gln Gly
             180                 185                 190    



      <210> 842
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 842
 Ser Ile Arg His Glu Arg Gln Pro Arg Val Arg Gly Arg Ala Ala Ser
   1               5                  10                  15    
 Glu Arg Phe Gly Glu Gln Thr Leu Pro Ser Val Ala Met Asp Cys Tyr
              20                  25                  30        
 Arg Thr Ser Leu Ser Ser Ser Trp Ile Tyr Pro Thr Val Ile Leu Cys
          35                  40                  45            
 Leu Phe Gly Phe Phe Ser Met Met Arg Pro Ser Glu Pro Phe Leu Ile
      50                  55                  60                
 Pro Tyr Leu Ser Gly Pro Asp Lys Asn Leu Thr Ser Ala Glu Ile Thr
  65                  70                  75                  80
 Asn Glu Ile Phe Pro Val Trp Thr Tyr Ser Tyr Leu Val Leu Leu Leu
                  85                  90                  95    
 Pro Val Phe Val Leu Thr Asp Tyr Val Arg Tyr Lys Pro Val Ile Ile
             100                 105                 110        
 Leu Gln Gly Ile Ser Phe Ile Ile Thr Trp Leu Leu Leu Leu Phe Gly
         115                 120                 125            
 Gln Gly Val Lys Thr Met Gln Val Val Glu Phe Phe Tyr Gly Met Val
     130                 135                 140                
 Thr Ala Ala Glu Val Ala Tyr Tyr Ala Tyr Ile Tyr Ser Val Val Ser
 145                 150                 155                 160
 Pro Glu His Tyr Gln Arg Val Ser Gly Tyr Cys Arg Ser Val Thr Leu
                 165                 170                 175    
 Ala Ala Tyr Thr Ala Gly Ser Val Leu Ala Gln Leu Leu Val Ser Leu
             180                 185                 190        
 Ala Asn Met Ser Tyr Phe Tyr Leu Asn Val Ile Ser Leu
         195                 200                 205



      <210> 843
      <211> 249
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(249)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 843
 Pro Cys Thr Ser Cys Val Leu Trp Ala Thr Leu His Leu Pro Ala Ser
   1               5                  10                  15    
 Thr Arg Lys Ala Pro Gln Ala Glu Cys Gly Met Ile Ser Ile Thr Glu
              20                  25                  30        
 Trp Gln Lys Ile Gly Val Gly Ile Thr Gly Phe Gly Ile Phe Phe Ile
          35                  40                  45            
 Leu Phe Gly Thr Leu Leu Tyr Phe Asp Ser Val Leu Leu Ala Phe Gly
      50                  55                  60                
 Asn Leu Leu Phe Leu Thr Gly Leu Ser Leu Ile Ile Gly Leu Arg Lys
  65                  70                  75                  80
 Thr Phe Trp Phe Phe Phe Gln Arg His Lys Leu Lys Gly Thr Ser Phe
                  85                  90                  95    
 Leu Leu Gly Gly Val Val Ile Val Leu Leu Arg Trp Pro Leu Leu Gly
             100                 105                 110        
 Met Phe Leu Glu Thr Tyr Gly Phe Phe Ser Leu Phe Lys Gly Phe Phe
         115                 120                 125            
 Pro Val Ala Phe Gly Phe Leu Gly Asn Val Cys Asn Ile Pro Phe Leu
     130                 135                 140                
 Gly Ala Leu Phe Arg Arg Leu Gln Gly Thr Ser Ser Met Val Xaa Lys
 145                 150                 155                 160
 Thr Glu Met Ser Ser Leu Asn Leu Asp His Trp Leu Lys Gly Ala Lys
                 165                 170                 175    
 Arg Glu Glu Trp Glu Pro Pro Pro Gln Ser Pro Ala Leu Thr His Ser
             180                 185                 190        
 Pro Thr Tyr Pro Gly Pro Pro Gln Val Gln Lys Glu Arg Asn Gly Ala
         195                 200                 205            
 Glu Gln Leu Thr Ser Asn Pro Gln Val Asp Ser Arg Gly Cys Gln Glu
     210                 215                 220                
 Ala Glu Met Gln Thr Pro Arg Arg Leu Gly Trp Gly Trp Tyr His Thr
 225                 230                 235                 240
 Leu Thr Leu Tyr Leu Trp Glu Glu Lys
                 245                



      <210> 844
      <211> 88
      <212> PRT
      <213> Homo sapiens


      <400> 844
 Gly Ile Ser His Glu Trp Ser Cys Asp Ser Glu Val Gly Ser Phe Ser
   1               5                  10                  15    
 Phe Leu Lys Ile Glu Thr Gly Ser Trp His Val Ala Glu Ala Gly Leu
              20                  25                  30        
 Arg Leu Leu Gly Ser Ser Asp Pro Pro Thr Ser Ala Ser Gln Ser Ala
          35                  40                  45            
 Gly Ile Thr Gly Val Ser Pro Arg Ala Arg Pro Ser Thr Arg Phe Ser
      50                  55                  60                
 Thr Thr Ala Ala Pro Arg Ser Ser Glu His Phe Leu Leu Cys Lys Thr
  65                  70                  75                  80
 Glu Ile Leu Leu Phe Ser Leu Glu
                  85            



      <210> 845
      <211> 327
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(327)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 845
 Ala Ile Ala Pro Lys Asp Asp Leu Phe Tyr Gly Phe Leu Lys Pro Trp
   1               5                  10                  15    
 Leu Gly Asp Gly Leu Leu Leu Ser Lys Gly Asp Lys Trp Ser Arg His
              20                  25                  30        
 Arg Arg Leu Leu Thr Pro Ala Phe His Phe Asp Ile Leu Lys Pro Tyr
          35                  40                  45            
 Met Lys Ile Phe Asn Gln Ser Ala Asp Ile Met His Ala Lys Trp Arg
      50                  55                  60                
 His Leu Ala Glu Gly Ser Ala Val Ser Leu Asp Met Phe Glu His Ile
  65                  70                  75                  80
 Ser Leu Met Thr Leu Asp Ser Leu Gln Lys Cys Val Phe Ser Tyr Asn
                  85                  90                  95    
 Ser Asn Cys Gln Glu Lys Met Ser Asp Tyr Ile Ser Ala Ile Ile Glu
             100                 105                 110        
 Leu Ser Ala Leu Ser Val Arg Arg Gln Tyr Arg Leu His His Tyr Leu
         115                 120                 125            
 Asp Phe Ile Tyr Tyr Arg Ser Ala Asp Gly Arg Arg Phe Arg Gln Ala
     130                 135                 140                
 Cys Asp Met Val His His Phe Thr Thr Glu Val Ile Gln Glu Arg Arg
 145                 150                 155                 160
 Arg Ala Leu Arg Gln Gln Gly Ala Glu Ala Trp Leu Lys Ala Lys Gln
                 165                 170                 175    
 Gly Lys Thr Leu Asp Phe Ile Asp Val Leu Leu Leu Ala Arg Asp Glu
             180                 185                 190        
 Asp Gly Lys Glu Leu Ser Asp Glu Asp Ile Arg Ala Glu Ala Asp Thr
         195                 200                 205            
 Phe Met Phe Glu Gly His Asp Thr Xaa Ser Ser Gly Ile Ser Trp Met
     210                 215                 220                
 Leu Phe Asn Leu Ala Lys Tyr Pro Glu Tyr Gln Glu Lys Cys Arg Glu
 225                 230                 235                 240
 Glu Ile Gln Glu Val Met Lys Gly Arg Glu Leu Glu Glu Leu Glu Trp
                 245                 250                 255    
 Ala Arg Ile Arg Ile Asp Ser Asn Pro Thr His Arg Ala Asp Val Thr
             260                 265                 270        
 Thr Lys Gln Thr Thr His Thr Phe Leu Gly Ile Thr Met Arg Cys Ala
         275                 280                 285            
 Gly Phe Leu Ala Pro Phe His Arg Leu Val Thr Ala Val Val Thr Gly
     290                 295                 300                
 Asn Ile Thr Ala Ser Thr Ala Asn Thr Phe Ile Lys Ile Asp Thr Gly
 305                 310                 315                 320
 Ile Asp Asn Ile Thr Ala Val
                 325        



      <210> 846
      <211> 702
      <212> PRT
      <213> Homo sapiens


      <400> 846
 Ala Tyr Tyr Arg His Lys Val Ser Glu Phe Lys Glu Gly Lys Ala Gln
   1               5                  10                  15    
 Glu Pro Ser Ala Ala Ile Pro Lys Val Met Gln Gln Gln Gln Gln Thr
              20                  25                  30        
 Thr Gln Gln Gln Leu Pro Gln Lys Val Gln Ala Gln Val Ile Gln Glu
          35                  40                  45            
 Thr Ile Val Pro Lys Glu Pro Pro Pro Glu Phe Glu Phe Ile Ala Asp
      50                  55                  60                
 Pro Pro Ser Ile Ser Ala Phe Asp Leu Asp Val Val Lys Leu Thr Ala
  65                  70                  75                  80
 Gln Phe Val Ala Arg Asn Gly Arg Gln Phe Leu Thr Gln Leu Met Gln
                  85                  90                  95    
 Lys Glu Gln Arg Asn Tyr Gln Phe Asp Phe Leu Arg Pro Gln His Ser
             100                 105                 110        
 Leu Phe Asn Tyr Phe Thr Lys Leu Val Glu Gln Tyr Thr Lys Ile Leu
         115                 120                 125            
 Ile Pro Pro Lys Gly Leu Phe Ser Lys Leu Lys Lys Glu Ala Glu Asn
     130                 135                 140                
 Pro Arg Glu Val Leu Asp Gln Val Cys Tyr Arg Val Glu Trp Ala Lys
 145                 150                 155                 160
 Phe Gln Glu Arg Glu Arg Lys Lys Glu Glu Glu Glu Lys Glu Lys Glu
                 165                 170                 175    
 Arg Val Ala Tyr Ala Gln Ile Asp Trp His Asp Phe Val Val Val Glu
             180                 185                 190        
 Thr Val Asp Phe Gln Pro Asn Glu Gln Gly Asn Phe Pro Pro Pro Thr
         195                 200                 205            
 Thr Pro Glu Glu Leu Gly Ala Arg Ile Leu Ile Gln Glu Arg Tyr Glu
     210                 215                 220                
 Lys Phe Gly Glu Ser Glu Glu Val Glu Met Glu Val Glu Ser Asp Glu
 225                 230                 235                 240
 Glu Asp Asp Lys Gln Glu Lys Ala Glu Glu Pro Pro Ser Gln Leu Asp
                 245                 250                 255    
 Gln Asp Thr Gln Val Gln Asp Met Asp Glu Gly Ser Asp Asp Glu Glu
             260                 265                 270        
 Glu Gly Gln Lys Val Pro Pro Pro Pro Glu Thr Pro Met Pro Pro Pro
         275                 280                 285            
 Leu Pro Pro Thr Pro Asp Gln Val Ile Val Arg Lys Asp Tyr Asp Pro
     290                 295                 300                
 Lys Ala Ser Lys Pro Leu Pro Pro Ala Pro Ala Pro Asp Glu Tyr Leu
 305                 310                 315                 320
 Val Ser Pro Ile Thr Gly Glu Lys Ile Pro Ala Ser Lys Met Gln Glu
                 325                 330                 335    
 His Met Arg Ile Gly Leu Leu Asp Pro Arg Trp Leu Glu Gln Arg Asp
             340                 345                 350        
 Arg Ser Ile Arg Glu Lys Gln Ser Asp Asp Glu Val Tyr Ala Pro Gly
         355                 360                 365            
 Leu Asp Ile Glu Ser Ser Leu Lys Gln Leu Ala Glu Arg Arg Thr Asp
     370                 375                 380                
 Ile Phe Gly Val Glu Glu Thr Ala Ile Gly Lys Lys Ile Gly Glu Glu
 385                 390                 395                 400
 Glu Ile Gln Lys Pro Glu Glu Lys Val Thr Trp Asp Gly His Ser Gly
                 405                 410                 415    
 Ser Met Ala Arg Thr Gln Gln Ala Ala Gln Ala Asn Ile Thr Leu Gln
             420                 425                 430        
 Glu Gln Ile Glu Ala Ile His Lys Ala Lys Gly Leu Val Pro Glu Asp
         435                 440                 445            
 Asp Thr Lys Glu Lys Ile Gly Pro Ser Lys Pro Asn Glu Ile Pro Gln
     450                 455                 460                
 Gln Pro Pro Pro Pro Ser Ser Ala Thr Asn Ile Pro Ser Ser Ala Pro
 465                 470                 475                 480
 Pro Ile Thr Ser Val Pro Arg Pro Pro Thr Met Pro Pro Pro Val Arg
                 485                 490                 495    
 Thr Thr Val Val Ser Ala Val Pro Val Met Pro Arg Pro Pro Met Ala
             500                 505                 510        
 Ser Val Val Arg Leu Pro Pro Gly Ser Val Ile Ala Pro Met Pro Pro
         515                 520                 525            
 Ile Ile His Ala Pro Arg Ile Asn Val Val Pro Met Pro Pro Ser Ala
     530                 535                 540                
 Pro Pro Ile Met Ala Pro Arg Pro Pro Pro Met Ile Val Pro Thr Ala
 545                 550                 555                 560
 Phe Val Pro Ala Pro Pro Val Ala Pro Val Pro Ala Pro Ala Pro Met
                 565                 570                 575    
 Pro Pro Val His Pro Pro Pro Pro Met Glu Asp Glu Pro Thr Ser Lys
             580                 585                 590        
 Lys Leu Lys Thr Glu Asp Ser Leu Met Pro Glu Glu Glu Phe Leu Arg
         595                 600                 605            
 Arg Asn Lys Gly Pro Val Ser Ile Lys Val Gln Val Pro Asn Met Gln
     610                 615                 620                
 Asp Lys Thr Glu Trp Lys Leu Asn Gly Gln Val Leu Val Phe Thr Leu
 625                 630                 635                 640
 Pro Leu Thr Asp Gln Val Ser Val Ile Lys Val Lys Ile His Glu Ala
                 645                 650                 655    
 Thr Gly Met Pro Ala Gly Lys Gln Lys Leu Gln Tyr Glu Gly Ile Phe
             660                 665                 670        
 Ile Lys Asp Ser Asn Ser Leu Ala Tyr Tyr Asn Met Ala Asn Gly Ala
         675                 680                 685            
 Val Ile His Leu Ala Leu Lys Glu Arg Gly Gly Arg Lys Lys
     690                 695                 700        



      <210> 847
      <211> 155
      <212> PRT
      <213> Homo sapiens


      <400> 847
 Met Phe Thr Leu Leu Val Leu Leu Ser Gln Leu Pro Thr Val Thr Leu
   1               5                  10                  15    
 Gly Phe Pro His Cys Ala Arg Gly Pro Lys Ala Ser Lys His Ala Gly
              20                  25                  30        
 Glu Glu Val Phe Thr Ser Lys Glu Glu Ala Asn Phe Phe Ile His Arg
          35                  40                  45            
 Arg Leu Leu Tyr Asn Arg Phe Asp Leu Glu Leu Phe Thr Pro Gly Asn
      50                  55                  60                
 Leu Glu Arg Glu Cys Asn Glu Glu Leu Cys Asn Tyr Glu Glu Ala Arg
  65                  70                  75                  80
 Glu Ile Phe Val Asp Glu Asp Lys Thr Ile Ala Phe Trp Gln Glu Tyr
                  85                  90                  95    
 Ser Ala Lys Gly Pro Thr Thr Lys Ser Asp Gly Asn Arg Glu Lys Ile
             100                 105                 110        
 Asp Val Met Gly Leu Leu Thr Gly Leu Ile Ala Ala Gly Val Phe Leu
         115                 120                 125            
 Val Ile Phe Gly Leu Leu Gly Tyr Tyr Leu Cys Ile Thr Lys Cys Asn
     130                 135                 140                
 Arg Leu Gln His Pro Cys Ser Ser Ala Val Tyr
 145                 150                 155



      <210> 848
      <211> 437
      <212> PRT
      <213> Homo sapiens


      <400> 848
 Phe Val Arg Leu Val Gly Arg Gly Asp Cys Asp Pro Leu Leu Ser Val
   1               5                  10                  15    
 Cys Leu Thr Thr Met Pro Leu Tyr Glu Gly Leu Gly Ser Gly Gly Glu
              20                  25                  30        
 Lys Thr Ala Val Val Ile Asp Leu Gly Glu Ala Phe Thr Lys Cys Gly
          35                  40                  45            
 Phe Ala Gly Glu Thr Gly Pro Arg Cys Ile Ile Pro Ser Val Ile Lys
      50                  55                  60                
 Arg Ala Gly Met Pro Lys Pro Val Arg Val Val Gln Tyr Asn Ile Asn
  65                  70                  75                  80
 Thr Glu Glu Leu Tyr Ser Tyr Leu Lys Glu Phe Ile His Ile Leu Tyr
                  85                  90                  95    
 Phe Arg His Leu Leu Val Asn Pro Arg Asp Arg Arg Val Val Ile Ile
             100                 105                 110        
 Glu Ser Val Leu Cys Pro Ser His Phe Arg Glu Thr Leu Thr Arg Val
         115                 120                 125            
 Leu Phe Lys Tyr Phe Glu Val Pro Ser Val Leu Leu Ala Pro Ser His
     130                 135                 140                
 Leu Met Ala Leu Leu Thr Leu Gly Ile Asn Ser Ala Met Val Leu Asp
 145                 150                 155                 160
 Cys Gly Tyr Arg Glu Ser Leu Val Leu Pro Ile Tyr Glu Gly Ile Pro
                 165                 170                 175    
 Val Leu Asn Cys Trp Gly Ala Leu Pro Leu Gly Gly Lys Ala Leu His
             180                 185                 190        
 Lys Glu Leu Glu Thr Gln Leu Leu Glu Gln Cys Thr Val Asp Thr Ser
         195                 200                 205            
 Val Ala Lys Glu Gln Ser Leu Pro Ser Val Met Gly Ser Val Pro Glu
     210                 215                 220                
 Gly Val Leu Glu Asp Ile Lys Ala Arg Thr Cys Phe Val Ser Asp Leu
 225                 230                 235                 240
 Lys Arg Gly Leu Lys Ile Gln Ala Ala Lys Phe Asn Ile Asp Gly Asn
                 245                 250                 255    
 Asn Glu Arg Pro Ser Pro Pro Pro Asn Val Asp Tyr Pro Leu Asp Gly
             260                 265                 270        
 Glu Lys Ile Leu His Ile Leu Gly Ser Ile Arg Asp Ser Val Val Glu
         275                 280                 285            
 Ile Leu Phe Glu Gln Asp Asn Glu Glu Gln Ser Val Ala Thr Leu Ile
     290                 295                 300                
 Leu Asp Ser Leu Ile Gln Cys Pro Ile Asp Thr Arg Lys Gln Leu Ala
 305                 310                 315                 320
 Glu Asn Leu Val Val Ile Gly Gly Thr Ser Met Leu Pro Gly Phe Leu
                 325                 330                 335    
 His Arg Leu Leu Ala Glu Ile Arg Tyr Leu Val Glu Lys Pro Lys Tyr
             340                 345                 350        
 Lys Lys Ala Leu Gly Thr Lys Thr Phe Arg Ile His Thr Pro Pro Ala
         355                 360                 365            
 Lys Ala Asn Cys Val Ala Trp Leu Gly Gly Ala Ile Phe Gly Ala Leu
     370                 375                 380                
 Gln Asp Ile Leu Gly Ser Arg Ser Val Ser Lys Glu Tyr Tyr Asn Gln
 385                 390                 395                 400
 Thr Gly Arg Ile Pro Asp Trp Cys Ser Leu Asn Asn Pro Pro Leu Glu
                 405                 410                 415    
 Met Met Phe Asp Val Gly Lys Thr Gln Pro Pro Leu Met Lys Arg Ala
             420                 425                 430        
 Phe Ser Thr Glu Lys
         435        



      <210> 849
      <211> 219
      <212> PRT
      <213> Homo sapiens


      <400> 849
 Trp Ser Ile Gln Arg Asn Leu Ser Leu Gly Ala Lys Ser Glu Ile Ala
   1               5                  10                  15    
 Thr Asp Lys Leu Ser Phe Pro Leu Lys Asn Ile Thr Arg Lys Asn Ile
              20                  25                  30        
 Ala Lys Met Ile Ala Gly Asn Ser Thr Glu Ser Ser Lys Thr Pro Val
          35                  40                  45            
 Thr Ile Glu Lys Ile Tyr Pro Tyr Tyr Val Lys Ala Pro Ser Asp Ser
      50                  55                  60                
 Asn Ser Lys Pro Ile Lys Gln Leu Leu Ser Glu Asn Asn Phe Met Asp
  65                  70                  75                  80
 Ile Thr Ile Ile Leu Ser Arg Asp Asn Thr Thr Lys Tyr Asn Ser Glu
                  85                  90                  95    
 Trp Trp Val Leu Asn Leu Thr Gly Asn Arg Ile Tyr Asn Pro Asn Ser
             100                 105                 110        
 Gln Ala Leu Glu Leu Val Val Phe Asn Asp Lys Val Ser Pro Pro Ser
         115                 120                 125            
 Leu Gly Phe Leu Ala Gly Tyr Gly Ile Met Gly Leu Tyr Ala Ser Val
     130                 135                 140                
 Val Leu Val Ile Gly Lys Phe Val Arg Glu Phe Phe Ser Gly Ile Ser
 145                 150                 155                 160
 His Ser Ile Met Phe Glu Glu Leu Pro Asn Val Asp Arg Ile Leu Lys
                 165                 170                 175    
 Leu Cys Thr Asp Ile Phe Leu Val Arg Glu Thr Gly Glu Leu Glu Leu
             180                 185                 190        
 Glu Glu Asp Leu Tyr Ala Lys Leu Ile Phe Leu Tyr Arg Ser Pro Glu
         195                 200                 205            
 Thr Met Ile Lys Trp Thr Arg Glu Lys Thr Asn
     210                 215                



      <210> 850
      <211> 133
      <212> PRT
      <213> Homo sapiens


      <400> 850
 Thr Lys Arg Lys Ala Met Glu Thr Ser Ala Ser Ser Ser Gln Pro Gln
   1               5                  10                  15    
 Asp Asn Ser Gln Val His Arg Glu Thr Glu Asp Val Asp Tyr Gly Glu
              20                  25                  30        
 Thr Asp Phe His Lys Gln Asp Gly Lys Ala Gly Leu Phe Ser Gln Glu
          35                  40                  45            
 Gln Tyr Glu Arg Asn Lys Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser
      50                  55                  60                
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Ser Asn Asp Glu
  65                  70                  75                  80
 Asp Gln Gln Pro Arg Ala Thr Gly Lys His Arg Arg Ser Leu Gly Ala
                  85                  90                  95    
 Gly Tyr Pro His Gly Asn Gly Ser Pro Gly Pro Gly His Gly Glu Pro
             100                 105                 110        
 Asp Val Leu Lys Asp Glu Leu Gln Leu Tyr Gly Asp Ala Pro Gly Glu
         115                 120                 125            
 Val Val Pro Ser Gly
     130            



      <210> 851
      <211> 86
      <212> PRT
      <213> Homo sapiens


      <400> 851
 Met Thr Thr Arg Gly Glu Asp Phe Leu Tyr Lys Ser Ser Gly Ala Ile
   1               5                  10                  15    
 Val Ala Ala Val Val Val Val Val Ile Ile Ile Phe Thr Val Val Leu
              20                  25                  30        
 Ile Leu Leu Lys Met Tyr Asn Arg Lys Met Arg Thr Arg Arg Glu Leu
          35                  40                  45            
 Glu Pro Lys Gly Pro Lys Pro Thr Ala Pro Ser Ala Val Gly Pro Asn
      50                  55                  60                
 Ser Asn Gly Ser Gln His Pro Ala Thr Val Thr Phe Ser Pro Val Asp
  65                  70                  75                  80
 Val His Val Glu Thr Arg
                  85    



      <210> 852
      <211> 360
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(360)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 852
 Gly Ser Phe Thr Lys Arg Val Arg Arg Ala Phe Lys Val Leu Arg Asp
   1               5                  10                  15    
 Asn Pro Thr Val Ala Lys Leu Ser Gln Val Lys Lys His Trp Tyr Phe
              20                  25                  30        
 Thr Trp Asn His Lys Arg Leu Lys Ile Ala Lys Ala Ile Leu Ser Lys
          35                  40                  45            
 Lys Asn Lys Pro Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Xaa Tyr
      50                  55                  60                
 Arg Ala Thr Val Ser Lys Thr Val Trp Tyr Trp His Lys Asn Arg His
  65                  70                  75                  80
 Ile Asn Gln Trp Asn Arg Ile Arg Asn Pro Glu Ala Asn Ala His Thr
                  85                  90                  95    
 Tyr Ile Xaa Leu Ile Phe Asp Lys Gly Ala Lys Asn Ile His Trp Val
             100                 105                 110        
 Lys Thr Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Xaa Ile Ser Ile
         115                 120                 125            
 Cys Lys Glu Trp Glu Lys Ile Ser Ala Asn Tyr Pro Ser Asp Lys Gly
     130                 135                 140                
 Leu Ile Thr Arg Ile Tyr Lys Glu Leu Lys Gln Leu Xaa Glu Lys Lys
 145                 150                 155                 160
 Ser Asn Asn Leu Ile Lys Lys Gln Ala Lys Asp Leu Asn Arg His Phe
                 165                 170                 175    
 Ser Lys Glu Asp Lys Xaa Met Ala Asn Arg His Met Lys Lys Cys Ser
             180                 185                 190        
 Met Leu Ile Thr Arg Glu Met Gln Ile Lys Thr Thr Met Lys Tyr His
         195                 200                 205            
 Phe Thr Pro Val Lys Met Val Tyr Ile Gln Lys Ala Gly Asn Asp Lys
     210                 215                 220                
 Cys Trp Gln Gly Cys Gly Glu Lys Gly Thr Phe Val His Cys Xaa Trp
 225                 230                 235                 240
 Glu Cys Lys Leu Val Xaa Pro Leu Xaa Arg Thr Val Trp Arg Phe Leu
                 245                 250                 255    
 Glu Lys Leu Glu Leu Glu Leu Pro Xaa Asp Pro Ala Ile Pro Leu Leu
             260                 265                 270        
 Gly Ile Tyr Pro Lys Xaa Arg Lys Ser Cys Val Ile Lys Glu Ile Thr
         275                 280                 285            
 Val Ala Lys Ile Trp Lys Gln Pro Lys Cys Pro Ser Thr Asp Lys Trp
     290                 295                 300                
 Ile Lys Lys Met Trp Tyr Ile Tyr Thr Met Asp Tyr Tyr Ser Ala Leu
 305                 310                 315                 320
 Lys Lys Asn Glu Ile Leu Ser Phe Pro Thr Thr Trp Met Glu Leu Lys
                 325                 330                 335    
 Ile Val Ile Leu Ser Val Ile Gly Gln Ser Gln Lys Asp Lys His Cys
             340                 345                 350        
 Met Phe Ser Leu Ile Cys Gly Ser
         355                 360



      <210> 853
      <211> 360
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(360)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 853
 Gly Ser Phe Thr Lys Arg Val Arg Arg Ala Phe Lys Val Leu Arg Asp
   1               5                  10                  15    
 Asn Pro Thr Val Ala Lys Leu Ser Gln Val Lys Lys His Trp Tyr Phe
              20                  25                  30        
 Thr Trp Asn His Lys Arg Leu Lys Ile Ala Lys Ala Ile Leu Ser Lys
          35                  40                  45            
 Lys Asn Lys Pro Gly Gly Ile Thr Leu Pro Asp Phe Lys Leu Xaa Tyr
      50                  55                  60                
 Arg Ala Thr Val Ser Lys Thr Val Trp Tyr Trp His Lys Asn Arg His
  65                  70                  75                  80
 Ile Asn Gln Trp Asn Arg Ile Arg Asn Pro Glu Ala Asn Ala His Thr
                  85                  90                  95    
 Tyr Ile Xaa Leu Ile Phe Asp Lys Gly Ala Lys Asn Ile His Trp Val
             100                 105                 110        
 Lys Thr Ser Leu Phe Asn Lys Trp Cys Trp Glu Asn Xaa Ile Ser Ile
         115                 120                 125            
 Cys Lys Glu Trp Glu Lys Ile Ser Ala Asn Tyr Pro Ser Asp Lys Gly
     130                 135                 140                
 Leu Ile Thr Arg Ile Tyr Lys Glu Leu Lys Gln Leu Xaa Glu Lys Lys
 145                 150                 155                 160
 Ser Asn Asn Leu Ile Lys Lys Gln Ala Lys Asp Leu Asn Arg His Phe
                 165                 170                 175    
 Ser Lys Glu Asp Lys Xaa Met Ala Asn Arg His Met Lys Lys Cys Ser
             180                 185                 190        
 Met Leu Ile Thr Arg Glu Met Gln Ile Lys Thr Thr Met Lys Tyr His
         195                 200                 205            
 Phe Thr Pro Val Lys Met Val Tyr Ile Gln Lys Ala Gly Asn Asp Lys
     210                 215                 220                
 Cys Trp Gln Gly Cys Gly Glu Lys Gly Thr Phe Val His Cys Xaa Trp
 225                 230                 235                 240
 Glu Cys Lys Leu Val Xaa Pro Leu Xaa Arg Thr Val Trp Arg Phe Leu
                 245                 250                 255    
 Glu Lys Leu Glu Leu Glu Leu Pro Xaa Asp Pro Ala Ile Pro Leu Leu
             260                 265                 270        
 Gly Ile Tyr Pro Lys Xaa Arg Lys Ser Cys Val Ile Lys Glu Ile Thr
         275                 280                 285            
 Val Ala Lys Ile Trp Lys Gln Pro Lys Cys Pro Ser Thr Asp Lys Trp
     290                 295                 300                
 Ile Lys Lys Met Trp Tyr Ile Tyr Thr Met Asp Tyr Tyr Ser Ala Leu
 305                 310                 315                 320
 Lys Lys Asn Glu Ile Leu Ser Phe Pro Thr Thr Trp Met Glu Leu Lys
                 325                 330                 335    
 Ile Val Ile Leu Ser Val Ile Gly Gln Ser Gln Lys Asp Lys His Cys
             340                 345                 350        
 Met Phe Ser Leu Ile Cys Gly Ser
         355                 360



      <210> 854
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 854
 Thr Cys Gly Ser Leu Lys Gly Gln Pro Arg Gln Glu Leu Arg Pro His
   1               5                  10                  15    
 Pro Glu Cys Ile Gly Arg Cys Arg Ser Met Gly Leu Gly Gly Cys Arg
              20                  25                  30        
 Gln Gly Lys Gly Arg Asp Gly Phe Ser Asp Met
          35                  40            



      <210> 855
      <211> 43
      <212> PRT
      <213> Homo sapiens


      <400> 855
 Thr Cys Gly Ser Leu Lys Gly Gln Pro Arg Gln Glu Leu Arg Pro His
   1               5                  10                  15    
 Pro Glu Cys Ile Gly Arg Cys Arg Ser Met Gly Leu Gly Gly Cys Arg
              20                  25                  30        
 Gln Gly Lys Gly Arg Asp Gly Phe Ser Asp Met
          35                  40            



      <210> 856
      <211> 53
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(53)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 856
 Gly Gly Arg Phe Lys Glu Ser Lys Leu Thr Asn Ala Gly Trp Gln Arg
   1               5                  10                  15    
 Asn Ser Phe Phe Ile Gly Pro Pro Lys Ser Ile Pro Trp Ala Ala Val
              20                  25                  30        
 Xaa Gln Arg Gly Asp Gly Lys Asn Pro Gly Val Thr His Leu Asn Arg
          35                  40                  45            
 Pro Val Gly Thr Xaa
      50            



      <210> 857
      <211> 281
      <212> PRT
      <213> Homo sapiens


      <400> 857
 Lys Ser Thr Arg Ser Val Phe Ala Arg Arg Arg Arg Thr Ala Cys Trp
   1               5                  10                  15    
 Gly Trp Ala Leu Pro Arg Gly Ser Gly Glu Glu Ala Val Ala Val Ser
              20                  25                  30        
 Gly Pro Gly Pro Val Gly Val Ala Val Ala Ile Met Ala Asp Pro Asp
          35                  40                  45            
 Pro Arg Tyr Pro Arg Ser Ser Ile Glu Asp Asp Phe Asn Tyr Gly Ser
      50                  55                  60                
 Ser Val Ala Ser Ala Thr Val His Ile Arg Met Ala Phe Leu Arg Lys
  65                  70                  75                  80
 Val Tyr Ser Ile Leu Ser Leu Gln Val Leu Leu Thr Thr Val Thr Ser
                  85                  90                  95    
 Thr Val Phe Leu Tyr Phe Glu Ser Val Arg Thr Phe Val His Glu Ser
             100                 105                 110        
 Pro Ala Leu Ile Leu Leu Phe Ala Leu Gly Ser Leu Gly Leu Ile Phe
         115                 120                 125            
 Ala Leu Ile Leu Asn Arg His Lys Tyr Pro Leu Asn Leu Tyr Leu Leu
     130                 135                 140                
 Phe Gly Phe Thr Leu Leu Glu Ala Leu Thr Val Ala Val Val Val Thr
 145                 150                 155                 160
 Phe Tyr Asp Val Tyr Ile Ile Leu Gln Ala Phe Ile Leu Thr Thr Thr
                 165                 170                 175    
 Val Phe Phe Gly Leu Thr Val Tyr Thr Leu Gln Ser Lys Lys Asp Phe
             180                 185                 190        
 Ser Lys Phe Gly Ala Gly Leu Phe Ala Leu Leu Trp Ile Leu Cys Leu
         195                 200                 205            
 Ser Gly Phe Leu Lys Phe Phe Phe Tyr Ser Glu Ile Met Glu Leu Val
     210                 215                 220                
 Leu Ala Ala Ala Gly Ala Leu Leu Phe Cys Gly Phe Ile Ile Tyr Asp
 225                 230                 235                 240
 Thr His Ser Leu Met His Lys Leu Ser Pro Glu Glu Tyr Val Leu Ala
                 245                 250                 255    
 Ala Ile Ser Leu Tyr Leu Asp Ile Ile Asn Leu Phe Leu His Leu Leu
             260                 265                 270        
 Arg Phe Leu Glu Ala Val Asn Lys Lys
         275                 280    



      <210> 858
      <211> 228
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(228)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 858
 Phe Gly Thr Ser Gly Gly Leu Val Ala Glu Val Ala Cys Ala Cys Arg
   1               5                  10                  15    
 Asp Cys Ile Pro Glu Thr Met Ala Glu Gly Asp Asn Arg Ser Thr Asn
              20                  25                  30        
 Leu Leu Ala Ala Glu Thr Ala Ser Leu Glu Glu Gln Leu Gln Gly Trp
          35                  40                  45            
 Gly Glu Val Met Leu Met Ala Asp Lys Val Leu Arg Trp Glu Arg Ala
      50                  55                  60                
 Trp Phe Pro Pro Ala Ile Met Gly Val Val Ser Leu Val Phe Leu Ile
  65                  70                  75                  80
 Ile Tyr Tyr Leu Asp Pro Ser Val Leu Ser Gly Val Ser Cys Phe Val
                  85                  90                  95    
 Met Phe Leu Cys Leu Ala Asp Tyr Leu Val Pro Ile Leu Ala Pro Arg
             100                 105                 110        
 Ile Phe Gly Ser Asn Lys Trp Thr Thr Glu Gln Gln Gln Arg Phe His
         115                 120                 125            
 Glu Ile Cys Ser Asn Leu Val Lys Thr Arg Arg Arg Ala Val Gly Trp
     130                 135                 140                
 Trp Lys Arg Leu Phe Thr Leu Lys Glu Glu Lys Pro Lys Met Tyr Phe
 145                 150                 155                 160
 Met Thr Met Ile Val Ser Leu Ala Ala Val Ala Trp Val Gly Gln Gln
                 165                 170                 175    
 Val His Asn Leu Leu Leu Thr Tyr Leu Ile Val Thr Ser Leu Leu Leu
             180                 185                 190        
 Leu Pro Trp Thr Xaa Thr Gln His Gly Asn His Phe Xaa Ser Thr Leu
         195                 200                 205            
 Gly Met Ala Lys Arg Glu Ile Asn Lys Leu Leu Lys Gln Lys Glu Lys
     210                 215                 220                
 Gly Lys Thr Glu
 225            



      <210> 859
      <211> 639
      <212> PRT
      <213> Homo sapiens


      <400> 859
 Pro Glu Arg Arg Pro Ala Glu Arg Ser Ser Pro Gly Gln Thr Pro Glu
   1               5                  10                  15    
 Glu Gly Ala Gln Ala Leu Ala Glu Phe Ala Ala Leu His Gly Pro Ala
              20                  25                  30        
 Leu Arg Ala Ser Gly Val Pro Glu Arg Tyr Trp Gly Arg Leu Leu His
          35                  40                  45            
 Lys Leu Glu His Glu Val Phe Asp Ala Gly Glu Val Phe Gly Ile Met
      50                  55                  60                
 Gln Val Glu Glu Val Glu Glu Glu Glu Asp Glu Ala Ala Arg Glu Val
  65                  70                  75                  80
 Arg Lys Gln Gln Pro Asn Pro Gly Asn Glu Leu Cys Tyr Lys Val Ile
                  85                  90                  95    
 Val Thr Arg Glu Ser Gly Leu Gln Ala Ala His Pro Asn Ser Ile Phe
             100                 105                 110        
 Leu Ile Asp His Ala Trp Thr Cys Arg Val Glu His Ala Arg Gln Gln
         115                 120                 125            
 Leu Gln Gln Val Pro Gly Leu Leu His Arg Met Ala Asn Leu Met Gly
     130                 135                 140                
 Ile Glu Phe His Gly Glu Leu Pro Ser Thr Glu Ala Val Ala Leu Val
 145                 150                 155                 160
 Leu Glu Glu Met Trp Lys Phe Asn Gln Thr Tyr Gln Leu Ala His Gly
                 165                 170                 175    
 Thr Ala Glu Glu Lys Met Pro Val Trp Tyr Ile Met Asp Glu Phe Gly
             180                 185                 190        
 Ser Arg Ile Gln His Ala Asp Val Pro Ser Phe Ala Thr Ala Pro Phe
         195                 200                 205            
 Phe Tyr Met Pro Gln Gln Val Ala Tyr Thr Leu Leu Trp Pro Leu Arg
     210                 215                 220                
 Asp Leu Asp Thr Gly Glu Glu Val Thr Arg Asp Phe Ala Tyr Gly Glu
 225                 230                 235                 240
 Thr Asp Pro Leu Ile Arg Lys Cys Met Leu Leu Pro Trp Ala Pro Thr
                 245                 250                 255    
 Asp Met Leu Asp Leu Ser Ser Cys Thr Pro Glu Pro Pro Ala Glu His
             260                 265                 270        
 Tyr Gln Ala Ile Leu Glu Glu Asn Lys Glu Lys Leu Pro Leu Asp Ile
         275                 280                 285            
 Asn Pro Val Val His Pro His Gly His Ile Phe Lys Val Tyr Thr Asp
     290                 295                 300                
 Val Gln Gln Val Ala Ser Ser Leu Thr His Pro Arg Phe Thr Leu Thr
 305                 310                 315                 320
 Gln Ser Glu Ala Asp Ala Asp Ile Leu Phe Asn Phe Ser His Phe Lys
                 325                 330                 335    
 Asp Tyr Arg Lys Leu Ser Gln Glu Arg Pro Gly Val Leu Leu Asn Gln
             340                 345                 350        
 Phe Pro Cys Glu Asn Leu Leu Thr Val Lys Asp Cys Leu Ala Ser Ile
         355                 360                 365            
 Ala Arg Arg Ala Gly Gly Pro Glu Gly Pro Pro Trp Leu Pro Arg Thr
     370                 375                 380                
 Phe Asn Leu Arg Thr Glu Leu Pro Gln Phe Val Ser Tyr Phe Gln Gln
 385                 390                 395                 400
 Arg Glu Arg Trp Gly Glu Asp Asn His Trp Ile Cys Lys Pro Trp Asn
                 405                 410                 415    
 Leu Ala Arg Ser Leu Asp Thr His Val Thr Lys Ser Leu His Ser Ile
             420                 425                 430        
 Ile Arg His Arg Glu Ser Thr Pro Lys Val Val Ser Lys Tyr Ile Glu
         435                 440                 445            
 Ser Pro Val Leu Phe Leu Arg Glu Asp Val Gly Lys Val Lys Phe Asp
     450                 455                 460                
 Ile Arg Tyr Ile Val Leu Leu Arg Ser Val Arg Pro Leu Arg Leu Phe
 465                 470                 475                 480
 Val Tyr Asp Val Phe Trp Gly Leu Arg Phe Ser Asn Arg Ala Phe Ala
                 485                 490                 495    
 Leu Asn Asp Leu Asp Asp Tyr Glu Lys His Phe Thr Val Met Asn Tyr
             500                 505                 510        
 Asp Pro Asp Val Val Leu Lys Gln Val His Cys Glu Glu Phe Ile Pro
         515                 520                 525            
 Glu Phe Glu Lys Gln Tyr Pro Glu Phe Pro Trp Thr Asp Val Gln Ala
     530                 535                 540                
 Glu Ile Phe Arg Ala Phe Thr Glu Leu Phe Gln Val Ala Cys Ala Lys
 545                 550                 555                 560
 Pro Pro Pro Leu Gly Leu Cys Asp Tyr Pro Ser Ser Arg Ala Met Tyr
                 565                 570                 575    
 Ala Val Asp Leu Met Leu Lys Trp Asp Asn Gly Pro Asp Gly Arg Arg
             580                 585                 590        
 Val Met Gln Pro Gln Ile Leu Glu Val Asn Phe Asn Pro Asp Cys Glu
         595                 600                 605            
 Arg Ala Cys Arg Tyr His Pro Thr Phe Phe Asn Asp Val Phe Ser Thr
     610                 615                 620                
 Leu Phe Leu Asp Gln Pro Gly Gly Cys His Val Thr Cys Leu Val
 625                 630                 635                



      <210> 860
      <211> 373
      <212> PRT
      <213> Homo sapiens


      <400> 860
 Ser Ile Phe His Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala Cys
   1               5                  10                  15    
 Leu Asp Glu Leu Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly Ala
              20                  25                  30        
 Gly Ala Gly Ala Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser Val
          35                  40                  45            
 Pro Gly Asp Pro Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr Pro
      50                  55                  60                
 Ala Val Pro Pro Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu Ala
  65                  70                  75                  80
 Ala Val Leu Glu Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu Leu
                  85                  90                  95    
 Leu Gln His Leu Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr Asn
             100                 105                 110        
 Leu Pro Gln His Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro Ala
         115                 120                 125            
 Glu Gln Cys Thr Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu Glu
     130                 135                 140                
 Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu Glu
 145                 150                 155                 160
 Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys Glu
                 165                 170                 175    
 Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp Tyr
             180                 185                 190        
 Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu Met
         195                 200                 205            
 Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly Asn
     210                 215                 220                
 Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val Lys
 225                 230                 235                 240
 Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln Ile
                 245                 250                 255    
 Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser Phe
             260                 265                 270        
 Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser Pro
         275                 280                 285            
 Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met Glu
     290                 295                 300                
 Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser Val
 305                 310                 315                 320
 Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val Gln
                 325                 330                 335    
 Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln Ser
             340                 345                 350        
 Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr Pro
         355                 360                 365            
 Pro Lys Glu Asp Gly
     370            



      <210> 861
      <211> 413
      <212> PRT
      <213> Homo sapiens


      <400> 861
 Gly Leu Asp Trp Asn Thr Trp Gly Pro Ile Gln Asn Ser Ala Arg Leu
   1               5                  10                  15    
 Ala Tyr Gly Phe Ser Ser Trp Asp Ile Ala Leu Leu Val Leu Trp Gly
              20                  25                  30        
 Pro Ile Gly Phe Leu Pro Cys Phe Ala Phe Met Trp Leu Leu Asp Lys
          35                  40                  45            
 Arg Gly Leu Arg Ile Thr Val Leu Leu Thr Ser Phe Leu Met Val Leu
      50                  55                  60                
 Gly Thr Gly Leu Arg Cys Ile Pro Ile Ser Asp Leu Ile Leu Lys Arg
  65                  70                  75                  80
 Arg Leu Ile His Gly Gly Gln Met Leu Asn Gly Leu Ala Gly Pro Thr
                  85                  90                  95    
 Val Met Asn Ala Ala Pro Phe Leu Ser Thr Thr Trp Phe Ser Ala Asp
             100                 105                 110        
 Glu Arg Ala Thr Ala Thr Ala Ile Ala Ser Met Leu Ser Tyr Leu Gly
         115                 120                 125            
 Gly Ala Cys Ala Phe Leu Val Gly Pro Leu Val Val Pro Ala Pro Asn
     130                 135                 140                
 Gly Thr Ser Pro Leu Leu Ala Ala Glu Ser Ser Arg Ala His Ile Lys
 145                 150                 155                 160
 Asp Arg Ile Glu Ala Val Leu Tyr Ala Glu Phe Gly Val Val Cys Leu
                 165                 170                 175    
 Ile Phe Ser Ala Thr Leu Ala Tyr Phe Pro Pro Arg Pro Pro Leu Pro
             180                 185                 190        
 Pro Ser Val Ala Ala Ala Ser Gln Arg Leu Ser Tyr Arg Arg Ser Val
         195                 200                 205            
 Cys Arg Leu Leu Ser Asn Phe Arg Phe Leu Met Ile Ala Leu Ala Tyr
     210                 215                 220                
 Ala Ile Pro Leu Gly Val Phe Ala Gly Trp Ser Gly Val Leu Asp Leu
 225                 230                 235                 240
 Ile Leu Thr Pro Ala His Val Ser Gln Val Asp Ala Gly Trp Ile Gly
                 245                 250                 255    
 Phe Trp Ser Ile Val Gly Gly Cys Val Val Gly Ile Ala Met Ala Arg
             260                 265                 270        
 Phe Ala Asp Phe Ile Arg Gly Met Leu Lys Leu Ile Leu Leu Leu Leu
         275                 280                 285            
 Phe Ser Gly Ala Thr Leu Ser Ser Thr Trp Phe Thr Leu Thr Cys Leu
     290                 295                 300                
 Asn Ser Ile Thr His Leu Pro Leu Thr Thr Val Thr Leu Tyr Ala Ser
 305                 310                 315                 320
 Cys Ile Leu Leu Gly Val Phe Leu Asn Ser Ser Val Pro Ile Phe Phe
                 325                 330                 335    
 Glu Leu Phe Val Glu Thr Val Tyr Pro Val Pro Glu Gly Ile Thr Cys
             340                 345                 350        
 Gly Val Val Thr Phe Leu Ser Asn Met Phe Met Gly Val Leu Leu Phe
         355                 360                 365            
 Phe Leu Thr Phe Tyr His Thr Glu Leu Ser Trp Phe Asn Trp Cys Leu
     370                 375                 380                
 Pro Gly Ser Cys Leu Leu Ser Leu Leu Leu Ile Leu Cys Phe Arg Glu
 385                 390                 395                 400
 Ser Tyr Asp Arg Leu Tyr Leu Asp Val Val Val Ser Val
                 405                 410            



      <210> 862
      <211> 336
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(336)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 862
 Gly Glu Ala Gly Lys Glu Arg Ala Pro Gly Lys Asp Gly Val Leu His
   1               5                  10                  15    
 Asp Pro Ala Leu Pro Lys Val Ala Arg Glu Thr Thr Met Lys Ala Ala
              20                  25                  30        
 Trp Cys Glu Arg Asp Pro Gly Gly Val Gln Ser Glu Ala Leu Cys Gly
          35                  40                  45            
 Asp Ser Gly Arg Met Leu Gly Gly Arg Glu Ala Gln Gly Val Pro Ser
      50                  55                  60                
 Pro Met Gln Val Pro Gly Cys Asp His Gly Gly Leu Val Arg Leu Leu
  65                  70                  75                  80
 Leu Pro Ser Gly Asp His His Gln Gly Gln Glu Trp Gly Ser Gln Cys
                  85                  90                  95    
 Arg Asp Pro Gly Lys Gly Pro Leu Pro Arg Thr Phe Ser Val Ser Arg
             100                 105                 110        
 Arg Ser Leu Ser Thr Gly Ser Gly Trp Arg Ala Ser Thr Pro His Ser
         115                 120                 125            
 Gly Thr Ala Ala Gly Arg Thr Gly Pro Xaa Trp Leu Gly His Cys Leu
     130                 135                 140                
 Ala His Pro His Pro Gly Gly Pro Pro Cys Cys Leu Gly Gln Gly Pro
 145                 150                 155                 160
 Ala Pro Cys Ala Xaa Ser Gln Arg Pro Gly Arg Val Pro Leu Ser Leu
                 165                 170                 175    
 Pro Gly Leu Ser Glu Gly Cys Arg Arg Arg Gly Gly Leu Ala Gln Thr
             180                 185                 190        
 Gly Arg Arg Gln Arg Arg Gln Cys Gly Xaa Arg His Trp Pro Ala Pro
         195                 200                 205            
 Ala Ala Arg Ala Ala Gly Trp Gly Gly Thr Cys Thr Gly Cys Ala Gly
     210                 215                 220                
 Pro Pro Arg Ser Pro Ser Arg Trp Cys Ser Pro Ala Arg Gly Gly Pro
 225                 230                 235                 240
 Arg Arg Arg Arg Leu Ser Gly Gly Leu Arg Ser Ala Gly Trp Arg Thr
                 245                 250                 255    
 Val Asp Pro Gln Gly Gly Ser Gly Gly Leu Gly Tyr Thr Gly Arg Leu
             260                 265                 270        
 Gln Cys Gln Gly Pro Glu Thr Gly Ser Gly Glu Gly Gly Asp Thr Val
         275                 280                 285            
 Gly Ala Asn Val Gly Ala Thr Gly Lys Ser Ser Arg Leu Ala Thr Arg
     290                 295                 300                
 His Val Pro Ser Ala Met Pro Ala Leu Glu Ala Asp Ala Leu Arg Glu
 305                 310                 315                 320
 Ala Glu Pro Ser Gln Gln Leu Xaa Xaa Gln Gln Pro Pro Gly Pro Gln
                 325                 330                 335    





      <210> 863
      <211> 336
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(336)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 863
 Gly Glu Ala Gly Lys Glu Arg Ala Pro Gly Lys Asp Gly Val Leu His
   1               5                  10                  15    
 Asp Pro Ala Leu Pro Lys Val Ala Arg Glu Thr Thr Met Lys Ala Ala
              20                  25                  30        
 Trp Cys Glu Arg Asp Pro Gly Gly Val Gln Ser Glu Ala Leu Cys Gly
          35                  40                  45            
 Asp Ser Gly Arg Met Leu Gly Gly Arg Glu Ala Gln Gly Val Pro Ser
      50                  55                  60                
 Pro Met Gln Val Pro Gly Cys Asp His Gly Gly Leu Val Arg Leu Leu
  65                  70                  75                  80
 Leu Pro Ser Gly Asp His His Gln Gly Gln Glu Trp Gly Ser Gln Cys
                  85                  90                  95    
 Arg Asp Pro Gly Lys Gly Pro Leu Pro Arg Thr Phe Ser Val Ser Arg
             100                 105                 110        
 Arg Ser Leu Ser Thr Gly Ser Gly Trp Arg Ala Ser Thr Pro His Ser
         115                 120                 125            
 Gly Thr Ala Ala Gly Arg Thr Gly Pro Xaa Trp Leu Gly His Cys Leu
     130                 135                 140                
 Ala His Pro His Pro Gly Gly Pro Pro Cys Cys Leu Gly Gln Gly Pro
 145                 150                 155                 160
 Ala Pro Cys Ala Xaa Ser Gln Arg Pro Gly Arg Val Pro Leu Ser Leu
                 165                 170                 175    
 Pro Gly Leu Ser Glu Gly Cys Arg Arg Arg Gly Gly Leu Ala Gln Thr
             180                 185                 190        
 Gly Arg Arg Gln Arg Arg Gln Cys Gly Xaa Arg His Trp Pro Ala Pro
         195                 200                 205            
 Ala Ala Arg Ala Ala Gly Trp Gly Gly Thr Cys Thr Gly Cys Ala Gly
     210                 215                 220                
 Pro Pro Arg Ser Pro Ser Arg Trp Cys Ser Pro Ala Arg Gly Gly Pro
 225                 230                 235                 240
 Arg Arg Arg Arg Leu Ser Gly Gly Leu Arg Ser Ala Gly Trp Arg Thr
                 245                 250                 255    
 Val Asp Pro Gln Gly Gly Ser Gly Gly Leu Gly Tyr Thr Gly Arg Leu
             260                 265                 270        
 Gln Cys Gln Gly Pro Glu Thr Gly Ser Gly Glu Gly Gly Asp Thr Val
         275                 280                 285            
 Gly Ala Asn Val Gly Ala Thr Gly Lys Ser Ser Arg Leu Ala Thr Arg
     290                 295                 300                
 His Val Pro Ser Ala Met Pro Ala Leu Glu Ala Asp Ala Leu Arg Glu
 305                 310                 315                 320
 Ala Glu Pro Ser Gln Gln Leu Xaa Xaa Gln Gln Pro Pro Gly Pro Gln
                 325                 330                 335    





      <210> 864
      <211> 102
      <212> PRT
      <213> Homo sapiens


      <400> 864
 Leu Phe Ile Gly Gly Pro Ser Asn Met Ile Arg Ser Ala Ile Ser Ala
   1               5                  10                  15    
 Asp Leu Gly Arg Gln Glu Leu Ile Gln Arg Ser Ser Glu Ala Leu Ala
              20                  25                  30        
 Thr Val Thr Gly Ile Val Asp Gly Ser Gly Ser Ile Gly Ala Ala Val
          35                  40                  45            
 Gly Gln Tyr Leu Val Ser Leu Ile Arg Asp Lys Leu Gly Trp Met Trp
      50                  55                  60                
 Val Phe Tyr Phe Phe Ile Leu Met Thr Ser Cys Thr Ile Val Phe Ile
  65                  70                  75                  80
 Ser Pro Leu Ile Val Arg Glu Ile Phe Ser Leu Val Leu Arg Arg Gln
                  85                  90                  95    
 Ala His Ile Leu Arg Glu
             100        



      <210> 865
      <211> 385
      <212> PRT
      <213> Homo sapiens


      <400> 865
 Gly Leu Lys Lys Glu Ile Gly Gln His Val Ala Gly Trp Thr Glu Asp
   1               5                  10                  15    
 Glu Glu Thr Arg Lys Leu Lys Leu Ala Val Leu Asn Ser Phe Phe Asn
              20                  25                  30        
 Leu Glu Cys Cys Val Ser Gly Thr His Ser Met Asp Leu Val Ala Leu
          35                  40                  45            
 Ala Pro Phe Gly Glu Tyr Thr Val Leu Pro Gly Leu Asp Cys Thr Phe
      50                  55                  60                
 Ser Lys Gly Tyr Gln Gly Leu Thr Asn Cys Met Met Ala Ala Leu Pro
  65                  70                  75                  80
 Glu Asp Thr Val Val Phe Glu Lys Pro Val Lys Thr Ile His Trp Asn
                  85                  90                  95    
 Gly Ser Phe Gln Glu Ala Ala Phe Pro Gly Glu Thr Phe Pro Val Ser
             100                 105                 110        
 Val Glu Cys Glu Asp Gly Asp Arg Phe Pro Ala His His Val Ile Val
         115                 120                 125            
 Thr Val Pro Leu Gly Phe Leu Arg Glu His Leu Asp Thr Phe Phe Asp
     130                 135                 140                
 Pro Pro Leu Pro Ala Glu Lys Ala Glu Ala Ile Arg Lys Ile Gly Phe
 145                 150                 155                 160
 Gly Thr Asn Asn Lys Ile Phe Leu Glu Phe Glu Glu Pro Phe Trp Glu
                 165                 170                 175    
 Pro Asp Cys Gln Leu Ile Gln Leu Val Trp Glu Asp Thr Ser Pro Leu
             180                 185                 190        
 Glu Asp Ala Ala Pro Glu Leu Gln Asp Ala Trp Phe Arg Lys Leu Ile
         195                 200                 205            
 Gly Phe Val Val Leu Pro Ala Phe Ala Ser Val His Val Leu Cys Gly
     210                 215                 220                
 Phe Ile Ala Gly Leu Glu Ser Glu Phe Met Glu Thr Leu Ser Asp Glu
 225                 230                 235                 240
 Glu Val Leu Leu Cys Leu Thr Gln Val Leu Arg Arg Val Thr Gly Asn
                 245                 250                 255    
 Pro Arg Leu Pro Ala Pro Lys Ser Val Leu Leu Ser Arg Trp His Ser
             260                 265                 270        
 Ala Pro Tyr Thr Arg Gly Ser Tyr Ser Tyr Val Ala Val Gly Ser Thr
         275                 280                 285            
 Gly Gly Asp Leu Asp Leu Leu Ala Gln Pro Leu Pro Ala Asp Gly Ala
     290                 295                 300                
 Gly Ala Gln Leu Gln Ile Leu Phe Ala Gly Glu Ala Thr His Arg Thr
 305                 310                 315                 320
 Phe Tyr Ser Thr Thr His Gly Ala Leu Leu Ser Gly Met Glu Gly Ser
                 325                 330                 335    
 Pro Thr Ala Ser Leu Ser Leu Trp Ala Pro Ala Gly Ala Ser Asn Pro
             340                 345                 350        
 Gln Ala Glu Ala Leu Ala Gly Pro Ser Pro Thr Leu Phe Pro Pro Val
         355                 360                 365            
 Ser Gly Val Gly Trp Asp Arg His Phe Phe Leu Thr Asp Phe Ser Leu
     370                 375                 380                
 Ala
 385



      <210> 866
      <211> 1343
      <212> PRT
      <213> Homo sapiens


      <400> 866
 Arg His Pro Gly Cys Gly Ala Gly Arg Pro Gly Ala Pro Pro Pro Arg
   1               5                  10                  15    
 His Gly Ser Arg Gly Gly Arg Gly Asp Arg Ala Arg Ala Gly Gly Gly
              20                  25                  30        
 Gly Pro Ser Arg Gly Ser Gly Gly Gly Gly Arg Gly Gly Leu Arg Ala
          35                  40                  45            
 Asp Gly Arg Ala Pro Gly Leu Arg Gly Leu Gly Ala Ala Pro His Cys
      50                  55                  60                
 Pro Ala Gly Leu Gly Pro Gly Ala Met Ser Gly Gly Gly Gly Gly Gly
  65                  70                  75                  80
 Gly Ser Ala Pro Ser Arg Phe Ala Asp Tyr Phe Val Ile Cys Gly Leu
                  85                  90                  95    
 Asp Thr Glu Thr Gly Leu Glu Pro Asp Glu Leu Ser Ala Leu Cys Gln
             100                 105                 110        
 Tyr Ile Gln Ala Ser Lys Ala Arg Asp Gly Ala Ser Pro Phe Ile Ser
         115                 120                 125            
 Ser Thr Thr Glu Gly Glu Asn Phe Glu Gln Thr Pro Leu Arg Arg Thr
     130                 135                 140                
 Phe Lys Ser Lys Val Leu Ala Arg Tyr Pro Glu Asn Val Glu Trp Asn
 145                 150                 155                 160
 Pro Phe Asp Gln Asp Ala Val Gly Met Leu Cys Met Pro Lys Gly Leu
                 165                 170                 175    
 Ala Phe Lys Thr Gln Ala Asp Pro Arg Glu Pro Gln Phe His Ala Phe
             180                 185                 190        
 Ile Ile Thr Arg Glu Asp Gly Ser Arg Thr Phe Gly Phe Ala Leu Thr
         195                 200                 205            
 Phe Tyr Glu Glu Val Thr Ser Lys Gln Ile Cys Ser Ala Met Gln Thr
     210                 215                 220                
 Leu Tyr His Met His Asn Ala Glu Tyr Asp Val Leu His Ala Pro Pro
 225                 230                 235                 240
 Ala Asp Asp Arg Asp Gln Ser Ser Met Glu Asp Gly Glu Asp Thr Pro
                 245                 250                 255    
 Val Thr Lys Leu Gln Arg Phe Asn Ser Tyr Asp Ile Ser Arg Asp Thr
             260                 265                 270        
 Leu Tyr Val Ser Lys Cys Ile Cys Leu Ile Thr Pro Met Ser Phe Met
         275                 280                 285            
 Lys Ala Cys Arg Ser Val Leu Glu Gln Leu His Gln Ala Val Thr Ser
     290                 295                 300                
 Pro Gln Pro Pro Pro Leu Pro Leu Glu Ser Tyr Ile Tyr Asn Val Leu
 305                 310                 315                 320
 Tyr Glu Val Pro Leu Pro Pro Pro Gly Arg Ser Leu Lys Phe Ser Gly
                 325                 330                 335    
 Val Tyr Gly Pro Ile Ile Cys Gln Arg Pro Ser Thr Asn Glu Leu Pro
             340                 345                 350        
 Leu Phe Asp Phe Pro Val Lys Glu Val Phe Glu Leu Leu Gly Val Glu
         355                 360                 365            
 Asn Val Phe Gln Leu Phe Thr Cys Ala Leu Leu Glu Phe Gln Ile Leu
     370                 375                 380                
 Leu Tyr Ser Gln His Tyr Gln Arg Leu Met Thr Val Ala Glu Thr Ile
 385                 390                 395                 400
 Thr Ala Leu Met Phe Pro Phe Gln Trp Gln His Val Tyr Val Pro Ile
                 405                 410                 415    
 Leu Pro Ala Ser Leu Leu His Phe Leu Asp Ala Pro Val Pro Tyr Leu
             420                 425                 430        
 Met Gly Leu His Ser Asn Gly Leu Asp Asp Arg Ser Lys Leu Glu Leu
         435                 440                 445            
 Pro Gln Glu Ala Asn Leu Cys Phe Val Asp Ile Asp Asn His Phe Ile
     450                 455                 460                
 Glu Leu Pro Glu Asp Leu Pro Gln Phe Pro Asn Lys Leu Glu Phe Val
 465                 470                 475                 480
 Gln Glu Val Ser Glu Ile Leu Met Ala Phe Gly Ile Pro Pro Glu Gly
                 485                 490                 495    
 Asn Leu His Cys Ser Glu Ser Ala Ser Lys Leu Lys Arg Leu Arg Ala
             500                 505                 510        
 Ser Glu Leu Val Ser Asp Lys Arg Asn Gly Asn Ile Ala Gly Ser Pro
         515                 520                 525            
 Leu His Ser Tyr Glu Leu Leu Lys Glu Asn Glu Thr Ile Ala Arg Leu
     530                 535                 540                
 Gln Ala Leu Val Lys Arg Thr Gly Val Ser Leu Glu Lys Leu Glu Val
 545                 550                 555                 560
 Arg Glu Asp Pro Ser Ser Asn Lys Asp Leu Lys Val Gln Cys Asp Glu
                 565                 570                 575    
 Glu Glu Leu Arg Ile Tyr Gln Leu Asn Ile Gln Ile Arg Glu Val Phe
             580                 585                 590        
 Ala Asn Arg Phe Thr Gln Met Phe Ala Asp Tyr Glu Val Phe Val Ile
         595                 600                 605            
 Gln Pro Ser Gln Asp Lys Glu Ser Trp Phe Thr Asn Arg Glu Gln Met
     610                 615                 620                
 Gln Asn Phe Asp Lys Ala Ser Phe Leu Ser Asp Gln Pro Glu Pro Tyr
 625                 630                 635                 640
 Leu Pro Phe Leu Ser Arg Phe Leu Glu Thr Gln Met Phe Ala Ser Phe
                 645                 650                 655    
 Ile Asp Asn Lys Ile Met Cys His Asp Asp Asp Asp Lys Asp Pro Val
             660                 665                 670        
 Leu Arg Val Phe Asp Ser Arg Val Asp Lys Ile Arg Leu Leu Asn Val
         675                 680                 685            
 Arg Thr Pro Thr Leu Arg Thr Ser Met Tyr Gln Lys Cys Thr Thr Val
     690                 695                 700                
 Asp Glu Ala Glu Lys Ala Ile Glu Leu Arg Leu Ala Lys Ile Asp His
 705                 710                 715                 720
 Thr Ala Ile His Pro His Leu Leu Asp Met Lys Ile Gly Gln Gly Lys
                 725                 730                 735    
 Tyr Glu Pro Gly Phe Phe Pro Lys Leu Gln Ser Asp Val Leu Ser Thr
             740                 745                 750        
 Gly Pro Ala Ser Asn Lys Trp Thr Lys Arg Asn Ala Pro Ala Gln Trp
         755                 760                 765            
 Arg Arg Lys Asp Arg Gln Lys Gln His Thr Glu His Leu Arg Leu Asp
     770                 775                 780                
 Asn Asp Gln Arg Glu Lys Tyr Ile Gln Glu Ala Arg Thr Met Gly Ser
 785                 790                 795                 800
 Thr Ile Arg Gln Pro Lys Leu Ser Asn Leu Ser Pro Ser Val Ile Ala
                 805                 810                 815    
 Gln Thr Asn Trp Lys Phe Val Glu Gly Leu Leu Lys Glu Cys Arg Asn
             820                 825                 830        
 Lys Thr Lys Arg Met Leu Val Glu Lys Met Gly Arg Glu Ala Val Glu
         835                 840                 845            
 Leu Gly His Gly Glu Val Asn Ile Thr Gly Val Glu Glu Asn Thr Leu
     850                 855                 860                
 Ile Ala Ser Leu Cys Asp Leu Leu Glu Arg Ile Trp Ser His Gly Leu
 865                 870                 875                 880
 Gln Val Lys Gln Gly Lys Ser Ala Leu Trp Ser His Leu Leu His Tyr
                 885                 890                 895    
 Gln Asp Asn Arg Gln Arg Lys Leu Thr Ser Gly Ser Leu Ser Thr Ser
             900                 905                 910        
 Gly Ile Leu Leu Asp Ser Glu Arg Arg Lys Ser Asp Ala Ser Ser Leu
         915                 920                 925            
 Met Pro Pro Leu Arg Ile Ser Leu Ile Gln Asp Met Arg His Ile Gln
     930                 935                 940                
 Asn Ile Gly Glu Ile Lys Thr Asp Val Gly Lys Ala Arg Ala Trp Val
 945                 950                 955                 960
 Arg Leu Ser Met Glu Lys Lys Leu Leu Ser Arg His Leu Lys Gln Leu
                 965                 970                 975    
 Leu Ser Asp His Glu Leu Thr Lys Lys Leu Tyr Lys Arg Tyr Ala Phe
             980                 985                 990        
 Leu Arg Cys Asp Asp Glu Lys Glu Gln Phe Leu Tyr His Leu Leu Ser
         995                1000                1005            
 Phe Asn Ala Val Asp Tyr Phe Cys Phe Thr Asn Val Phe Thr Thr Ile
    1010                1015                1020                
 Leu Ile Pro Tyr His Ile Leu Ile Val Pro Ser Lys Lys Leu Gly Gly
1025                1030                1035                1040
 Ser Met Phe Thr Ala Asn Pro Trp Ile Cys Ile Ser Gly Glu Leu Gly
                1045                1050                1055    
 Glu Thr Gln Ile Met Gln Ile Pro Arg Asn Val Leu Glu Met Thr Phe
            1060                1065                1070        
 Glu Cys Gln Asn Leu Gly Lys Leu Thr Thr Val Gln Ile Gly His Asp
        1075                1080                1085            
 Asn Ser Gly Leu Tyr Ala Lys Trp Leu Val Glu Tyr Val Met Val Arg
    1090                1095                1100                
 Asn Glu Ile Thr Gly His Thr Tyr Lys Phe Pro Cys Gly Arg Trp Leu
1105                1110                1115                1120
 Gly Lys Gly Met Asp Asp Gly Ser Leu Glu Arg Ile Leu Val Gly Glu
                1125                1130                1135    
 Leu Leu Thr Ser Gln Pro Glu Val Asp Glu Arg Pro Cys Arg Thr Pro
            1140                1145                1150        
 Pro Leu Gln Gln Ser Pro Ser Val Ile Arg Arg Leu Val Thr Ile Ser
        1155                1160                1165            
 Pro Asn Asn Lys Pro Lys Leu Asn Thr Gly Gln Ile Gln Glu Ser Ile
    1170                1175                1180                
 Gly Glu Ala Val Asn Gly Ile Val Lys His Phe His Lys Pro Glu Lys
1185                1190                1195                1200
 Glu Arg Gly Ser Leu Thr Leu Leu Leu Cys Gly Glu Cys Gly Leu Val
                1205                1210                1215    
 Ser Ala Leu Glu Gln Ala Phe Gln His Gly Phe Lys Ser Pro Arg Leu
            1220                1225                1230        
 Phe Lys Asn Val Phe Ile Trp Asp Phe Leu Glu Lys Ala Gln Thr Tyr
        1235                1240                1245            
 Tyr Glu Thr Leu Glu Lys Asn Glu Val Val Pro Glu Glu Asn Trp His
    1250                1255                1260                
 Thr Arg Ala Arg Asn Phe Cys Arg Phe Val Thr Ala Ile Asn Asn Thr
1265                1270                1275                1280
 Pro Arg Asn Ile Gly Lys Asp Gly Lys Phe Gln Met Leu Val Cys Leu
                1285                1290                1295    
 Gly Ala Arg Asp His Leu Leu His His Trp Ile Ala Leu Leu Ala Asp
            1300                1305                1310        
 Cys Pro Ile Thr Ala His Met Tyr Glu Asp Val Ala Leu Ile Lys Asp
        1315                1320                1325            
 His Thr Leu Val Asn Ser Leu Ile Arg Val Leu Gln Thr Leu Gln
    1330                1335                1340            



      <210> 867
      <211> 145
      <212> PRT
      <213> Homo sapiens


      <400> 867
 Pro Asn Arg Phe Ala Trp Cys Val Leu Leu Val Ala Ile His Leu Phe
   1               5                  10                  15    
 Ser Pro Gly Thr Ser Phe Ala Gly His Leu Ala Gly Ile Leu Val Gly
              20                  25                  30        
 Leu Met Tyr Thr Gln Gly Pro Leu Lys Lys Ile Met Glu Ala Cys Ala
          35                  40                  45            
 Gly Gly Phe Ser Phe Ser Val Gly Tyr Pro Gly Arg Gln Tyr Tyr Phe
      50                  55                  60                
 Asn Ser Ser Gly Ser Ser Gly Tyr Gln Asp Tyr Tyr Pro His Gly Arg
  65                  70                  75                  80
 Pro Asp His Tyr Glu Glu Ala Pro Arg Asn Tyr Asp Thr Tyr Thr Ala
                  85                  90                  95    
 Gly Leu Ser Glu Glu Glu Gln Leu Glu Arg Ala Leu Gln Ala Ser Leu
             100                 105                 110        
 Trp Asp Arg Gly Asn Thr Arg Asn Ser Pro Pro Pro Tyr Gly Phe His
         115                 120                 125            
 Leu Ser Pro Glu Glu Met Arg Arg Gln Arg Leu His Arg Phe Asp Ser
     130                 135                 140                
 Gln
 145



      <210> 868
      <211> 415
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(415)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 868
 Lys Val Glu Phe Glu Gln Leu Thr Leu Asp Gly His Asn Leu Pro Ser
   1               5                  10                  15    
 Leu Val Cys Val Ile Thr Gly Lys Gly Pro Leu Arg Glu Tyr Tyr Ser
              20                  25                  30        
 Arg Leu Ile His Gln Lys His Phe Gln His Ile Gln Val Cys Thr Pro
          35                  40                  45            
 Trp Leu Glu Ala Glu Asp Tyr Pro Leu Leu Leu Gly Ser Ala Asp Leu
      50                  55                  60                
 Gly Val Cys Leu His Thr Ser Ser Ser Gly Leu Asp Leu Pro Met Lys
  65                  70                  75                  80
 Val Val Asp Met Phe Gly Cys Cys Leu Pro Val Cys Ala Val Asn Phe
                  85                  90                  95    
 Lys Cys Leu His Glu Leu Val Lys His Glu Glu Asn Gly Leu Val Phe
             100                 105                 110        
 Glu Asp Ser Glu Glu Leu Ala Ala Gln Leu Gln Met Leu Phe Ser Asn
         115                 120                 125            
 Phe Pro Asp Pro Ala Gly Lys Leu Asn Gln Phe Arg Lys Asn Leu Cys
     130                 135                 140                
 Val Thr Asn Ala Met Arg Glu Asp Leu Ala Asp Ile Trp Tyr Ile Arg
 145                 150                 155                 160
 Ala Val Thr Val Tyr Asp Lys Pro Ala Ser Phe Phe Lys Glu Thr Pro
                 165                 170                 175    
 Leu Asp Leu Gln His Arg Leu Phe Met Lys Leu Gly Ser Met His Ser
             180                 185                 190        
 Pro Phe Arg Ala Arg Ser Glu Pro Glu Asp Pro Val Thr Glu Arg Ser
         195                 200                 205            
 Ala Phe Thr Glu Arg Asp Ala Gly Ser Gly Leu Val Thr Arg Leu Arg
     210                 215                 220                
 Glu Arg Pro Ala Leu Leu Val Ser Ser Thr Ser Trp Thr Glu Asp Glu
 225                 230                 235                 240
 Asp Phe Ser Ile Leu Leu Ala Ala Leu Glu Ser Arg Val Xaa Thr Met
                 245                 250                 255    
 Thr Leu Asp Gly His Asn Leu Pro Ser Leu Val Cys Val Ile Thr Gly
             260                 265                 270        
 Lys Gly Pro Leu Arg Glu Tyr Tyr Ser Arg Leu Ile His Gln Lys His
         275                 280                 285            
 Phe Gln His Ile Gln Val Cys Thr Pro Trp Leu Glu Ala Glu Asp Tyr
     290                 295                 300                
 Pro Leu Leu Leu Gly Ser Ala Asp Leu Gly Val Cys Leu His Thr Ser
 305                 310                 315                 320
 Ser Ser Gly Leu Asp Leu Pro Met Lys Val Val Asp Met Phe Gly Cys
                 325                 330                 335    
 Cys Leu Pro Val Cys Ala Val Asn Phe Lys Cys Leu His Glu Leu Val
             340                 345                 350        
 Lys His Glu Glu Asn Gly Leu Val Phe Glu Asp Ser Glu Glu Leu Ala
         355                 360                 365            
 Ala Gln Leu Gln Met Leu Phe Ser Asn Phe Pro Asp Pro Ala Gly Lys
     370                 375                 380                
 Leu Asn Gln Phe Arg Lys Asn Leu Arg Glu Ser Gln Gln Leu Arg Trp
 385                 390                 395                 400
 Asp Glu Ser Trp Val Gln Thr Val Leu Pro Leu Val Met Asp Thr
                 405                 410                 415



      <210> 869
      <211> 134
      <212> PRT
      <213> Homo sapiens


      <400> 869
 Asn Glu Pro Ser Leu Ser Ser Lys Arg Lys Met Cys Glu Met Ala Thr
   1               5                  10                  15    
 Ser Gly Asp Arg Gln Arg Asp Ser Glu Val Asn Phe Lys Glu Leu Arg
              20                  25                  30        
 Thr Ala Lys Met Lys Pro Glu Leu Leu Ser Gly His Ile Pro Pro Gly
          35                  40                  45            
 His Ile Pro Lys Pro Ile Val Met Pro Asp Tyr Val Ala Lys Tyr Pro
      50                  55                  60                
 Val Ile Gln Thr Asp Asp Glu Arg Glu Arg Tyr Lys Ala Val Phe Gln
  65                  70                  75                  80
 Asp Gln Phe Ser Glu Tyr Lys Glu Leu Ser Ala Glu Val Gln Ala Val
                  85                  90                  95    
 Leu Arg Lys Phe Asp Glu Leu Asp Ala Val Met Ser Arg Leu Pro His
             100                 105                 110        
 His Ser Glu Ser Arg Gln Glu His Glu Arg Ile Ser Arg Ile His Glu
         115                 120                 125            
 Glu Phe Lys Lys Lys Lys
     130                



      <210> 870
      <211> 146
      <212> PRT
      <213> Homo sapiens


      <400> 870
 Gly Thr Arg Lys Pro Val Tyr Lys His Pro Leu Val Phe Val Leu Leu
   1               5                  10                  15    
 Ala Val Leu Val Leu Ser Val Thr Thr Gln Ile Asn Tyr Leu Asn Lys
              20                  25                  30        
 Ala Leu Asp Thr Phe Asn Thr Ser Leu Val Thr Pro Ile Tyr Tyr Val
          35                  40                  45            
 Phe Phe Thr Ser Met Val Val Thr Cys Ser Ala Ile Leu Phe Gln Glu
      50                  55                  60                
 Trp Tyr Gly Met Thr Ala Gly Asp Ile Ile Gly Thr Leu Ser Gly Phe
  65                  70                  75                  80
 Phe Thr Ile Ile Ile Gly Ile Phe Leu Leu His Ala Phe Lys Asn Thr
                  85                  90                  95    
 Asp Ile Thr Trp Ser Glu Leu Thr Ser Thr Ala Lys Lys Glu Ala Val
             100                 105                 110        
 Ser Leu Asn Val Asn Glu Asn Asn Tyr Val Leu Leu Glu Asn Leu Glu
         115                 120                 125            
 Cys Ser Ala Pro Gly Tyr Asn Asp Asp Val Thr Leu Phe Ser Arg Thr
     130                 135                 140                
 Asp Asp
 145    



      <210> 871
      <211> 124
      <212> PRT
      <213> Homo sapiens


      <400> 871
 Phe Leu Ser Asn Phe Pro Asn Phe Gln His Asp Ile Asn Ile Ser Ser
   1               5                  10                  15    
 Ser Asn Glu Ile Ile Ser Ser Arg Gly Phe Ile Gln Thr Thr Asp Val
              20                  25                  30        
 Ser Ser Ser Ala Lys Lys Lys Ile Leu Leu Phe Gln Leu Arg Arg Ile
          35                  40                  45            
 Ala Glu Asp Cys Gln Ile Pro Leu Met Val Tyr Asn Gln Ala Phe Ile
      50                  55                  60                
 Tyr Phe Asp Gln Tyr Ala Ala Ile Leu Glu Asp Thr Val Arg Asn Val
  65                  70                  75                  80
 Leu Val Ala Ser Ala Ala Met Phe Ile Val Ser Leu Leu Leu Ile Pro
                  85                  90                  95    
 Tyr Pro Leu Cys Ser Leu Trp Val Thr Phe Ala Ile Gly Ser Val Ile
             100                 105                 110        
 Val Gly Val Thr Gly Phe Met Ala Phe Trp Lys Val
         115                 120                



      <210> 872
      <211> 524
      <212> PRT
      <213> Homo sapiens


      <400> 872
 Met Arg Ser Pro Cys Val Asn Lys Ile Gln Gly Leu Glu Pro Asn Ala
   1               5                  10                  15    
 Lys Pro Val Leu Ser Pro Ala Thr Leu Gln Leu Leu Ala Leu Met Tyr
              20                  25                  30        
 Pro Val Pro Phe Lys Glu Met Trp Ser Arg Lys Gly Asn Ala Tyr Thr
          35                  40                  45            
 Ala Asp Ser Gly Ala Glu Asn Tyr Gln Ser Leu Ile Ala Gly Ser Cys
      50                  55                  60                
 Asp Thr Arg Gly Leu Gly Tyr Val Gly Gly Val Ala Phe Gly Met Met
  65                  70                  75                  80
 Thr Thr Gly Asn Asn Glu Trp Pro Arg Ala Gln Ile Ser Val Gly Thr
                  85                  90                  95    
 Gln Asp Arg Asp Gly Ser Gly Asn Ile Gly Leu Gln Met His Phe Arg
             100                 105                 110        
 Phe Met Ala Ser Gly Gln Ile Ser Tyr Ala Gly Pro Gln Gly Ala Gly
         115                 120                 125            
 Ser Phe Gln Gln Val Pro Ala Ser Asp Arg Asn Ile Lys His Ser Ile
     130                 135                 140                
 Lys Asp Asp Glu Ser Ser Ile Ala Tyr Asn Asn Ile Lys Ser Met Arg
 145                 150                 155                 160
 Phe Arg Asn Phe Ile Phe Asn Asp Asp Glu Gln Glu Arg Leu Gly Ala
                 165                 170                 175    
 Arg Arg His Asn Gln His His Leu Val Ala Met Val Asp Thr Glu Ser
             180                 185                 190        
 Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala Gly Asp Leu Glu Ser Pro
         195                 200                 205            
 Leu Ser Glu Glu Phe Leu Gln Glu Met Gly Asn Ile Gln Glu Ile Ser
     210                 215                 220                
 Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser Phe Gly Phe Thr Glu Tyr
 225                 230                 235                 240
 Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp Gly Ser Val Ile Thr Gly
                 245                 250                 255    
 Ser Ile Gln Gln Thr Ala Ala Val Glu Lys Glu Glu Tyr Gly Ala Ala
             260                 265                 270        
 Ala Thr Glu Gly His Val Ala Leu Leu Gly Pro Ser Ser Thr Ile His
         275                 280                 285            
 Asn Lys Ile Thr Asn Arg Thr His Asp Trp Gly Ala Leu Ala Leu Asp
     290                 295                 300                
 Gly Gly Pro Val Pro Arg Cys Ser Gly Cys Arg Val Gln Val Val Gly
 305                 310                 315                 320
 Trp Leu Cys Ile Pro Pro Arg Lys Ala Lys Cys Leu Thr Gln Arg Glu
                 325                 330                 335    
 His Tyr Pro Phe Tyr Lys Val Ile Asn Thr Gly Cys Gln Val Pro His
             340                 345                 350        
 Leu Lys Lys Asn Leu Asp His Leu Leu Gly Met Gly Ser Ser Arg Ala
         355                 360                 365            
 Trp Leu Pro Ser Thr Gln Ile His Arg Trp Arg Gly Ala Ala Gly Gly
     370                 375                 380                
 Pro Arg Thr Ser Arg Phe Leu Arg Ala Thr Pro Glu Arg Leu Gln Pro
 385                 390                 395                 400
 Leu Ala Ala Pro Gly Lys Ala Ser Arg Pro Met Trp Pro Arg Pro Arg
                 405                 410                 415    
 Ala Pro Pro Glu Thr Ser Gly Ala His Arg Gly Leu Gly Lys Ile Leu
             420                 425                 430        
 Arg Asp Leu Thr Ala Gln Gly Arg Thr His Ser Ser His Lys Gln Leu
         435                 440                 445            
 Glu Met Asp Gly Leu Ala Glu Lys Gly Asn Pro Ser Thr Asn Pro Ala
     450                 455                 460                
 Pro Gly Pro Thr Leu Gln Gln Val Cys Pro Cys Gln Ser Pro Arg Gly
 465                 470                 475                 480
 Ala Gln Pro Asp Pro Asp Arg Trp Pro Gly Gly Thr Gln Gly Phe Gly
                 485                 490                 495    
 Gln Pro Leu Ser Trp Ala Gln Val Ser Trp Arg Ser Gln Gly Arg Gln
             500                 505                 510        
 Gly Leu Pro Pro Leu Ala Thr Tyr Pro Gly Asp Ala
         515                 520                



      <210> 873
      <211> 316
      <212> PRT
      <213> Homo sapiens


      <400> 873
 Pro Pro Leu Pro Pro Arg Ser Phe Pro Asn Leu Phe Ser Arg Pro Glu
   1               5                  10                  15    
 Pro Leu Pro Glu Pro Gly Arg Arg Gly Cys Asn Arg Ser Arg Glu Pro
              20                  25                  30        
 Ala Ala Arg Ala Pro Ser Pro Pro Pro Pro Phe Glu Gly Ala Pro Gly
          35                  40                  45            
 Arg Ala Met Val Lys Val Thr Phe Asn Ser Ala Leu Ala Gln Lys Glu
      50                  55                  60                
 Ala Lys Lys Asp Glu Pro Lys Ser Gly Glu Glu Ala Leu Ile Ile Pro
  65                  70                  75                  80
 Pro Asp Ala Val Ala Val Asp Cys Lys Asp Pro Asp Asp Val Val Pro
                  85                  90                  95    
 Val Gly Gln Arg Arg Ala Trp Cys Trp Cys Met Cys Phe Gly Leu Ala
             100                 105                 110        
 Phe Met Leu Ala Gly Val Ile Leu Gly Gly Ala Tyr Leu Tyr Lys Tyr
         115                 120                 125            
 Phe Ala Leu Gln Pro Asp Asp Val Tyr Tyr Cys Gly Ile Lys Tyr Ile
     130                 135                 140                
 Lys Asp Asp Val Ile Leu Asn Glu Pro Ser Ala Asp Ala Pro Ala Ala
 145                 150                 155                 160
 Leu Tyr Gln Thr Ile Glu Glu Asn Ile Lys Ile Phe Glu Glu Glu Glu
                 165                 170                 175    
 Val Glu Phe Ile Ser Val Pro Val Pro Glu Phe Ala Asp Ser Asp Pro
             180                 185                 190        
 Ala Asn Ile Val His Asp Phe Asn Lys Lys Leu Thr Ala Tyr Leu Asp
         195                 200                 205            
 Leu Asn Leu Asp Lys Cys Tyr Val Ile Pro Leu Asn Thr Ser Ile Val
     210                 215                 220                
 Met Pro Pro Arg Asn Leu Leu Glu Leu Leu Ile Asn Ile Lys Ala Gly
 225                 230                 235                 240
 Thr Tyr Leu Pro Gln Ser Tyr Leu Ile His Glu His Met Val Ile Thr
                 245                 250                 255    
 Asp Arg Ile Glu Asn Ile Asp His Leu Gly Phe Phe Ile Tyr Arg Leu
             260                 265                 270        
 Cys His Asp Lys Glu Thr Tyr Lys Leu Gln Arg Arg Glu Thr Ile Lys
         275                 280                 285            
 Gly Ile Gln Lys Arg Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe
     290                 295                 300                
 Glu Asn Lys Phe Ala Val Glu Thr Leu Ile Cys Ser
 305                 310                 315    



      <210> 874
      <211> 315
      <212> PRT
      <213> Homo sapiens


      <400> 874
 Met Phe Phe Gly Ser Ala Ala Leu Gly Thr Leu Thr Gly Leu Ile Ser
   1               5                  10                  15    
 Ala Leu Val Leu Lys His Ile Asp Leu Arg Lys Thr Pro Ser Leu Glu
              20                  25                  30        
 Phe Gly Met Met Ile Ile Phe Ala Tyr Leu Pro Tyr Gly Leu Ala Glu
          35                  40                  45            
 Gly Ile Ser Leu Ser Gly Ile Met Ala Ile Leu Phe Ser Gly Ile Val
      50                  55                  60                
 Met Ser His Tyr Thr His His Asn Leu Ser Pro Val Thr Gln Ile Leu
  65                  70                  75                  80
 Met Gln Gln Thr Leu Arg Thr Val Ala Phe Leu Cys Glu Thr Cys Val
                  85                  90                  95    
 Phe Ala Phe Leu Gly Leu Ser Ile Phe Ser Phe Pro His Lys Phe Glu
             100                 105                 110        
 Ile Ser Phe Val Ile Trp Cys Ile Val Leu Val Leu Phe Gly Arg Ala
         115                 120                 125            
 Val Asn Ile Phe Pro Leu Ser Tyr Leu Leu Asn Phe Phe Arg Asp His
     130                 135                 140                
 Lys Ile Thr Pro Lys Met Met Phe Ile Met Trp Phe Ser Gly Leu Arg
 145                 150                 155                 160
 Gly Ala Ile Pro Tyr Ala Leu Ser Leu His Leu Asp Leu Glu Pro Met
                 165                 170                 175    
 Glu Lys Arg Gln Leu Ile Gly Thr Thr Thr Ile Val Ile Val Leu Phe
             180                 185                 190        
 Thr Ile Leu Leu Leu Gly Gly Ser Thr Met Pro Leu Ile Arg Leu Met
         195                 200                 205            
 Asp Ile Glu Asp Ala Lys Ala His Arg Arg Asn Lys Lys Asp Val Asn
     210                 215                 220                
 Leu Ser Lys Thr Glu Lys Met Gly Asn Thr Val Glu Ser Glu His Leu
 225                 230                 235                 240
 Ser Glu Leu Thr Glu Glu Glu Tyr Glu Ala His Tyr Ile Arg Arg Gln
                 245                 250                 255    
 Asp Leu Lys Gly Phe Val Trp Leu Asp Ala Lys Tyr Leu Asn Pro Phe
             260                 265                 270        
 Phe Thr Arg Arg Leu Thr Gln Glu Asp Leu His His Gly Arg Ile Gln
         275                 280                 285            
 Met Lys Thr Leu Thr Asn Lys Trp Tyr Glu Glu Val Arg Gln Gly Pro
     290                 295                 300                
 Ser Gly Ser Glu Asp Asp Glu Gln Glu Leu Leu
 305                 310                 315



      <210> 875
      <211> 248
      <212> PRT
      <213> Homo sapiens


      <400> 875
 Phe Glu Gly Asn Val Phe Met Tyr Tyr Gly Leu Ser Asn Phe Tyr Gln
   1               5                  10                  15    
 Asn His Arg Arg Tyr Val Lys Ser Arg Asp Asp Ser Gln Leu Asn Gly
              20                  25                  30        
 Asp Ser Ser Ala Leu Leu Asn Pro Ser Lys Glu Cys Glu Pro Tyr Arg
          35                  40                  45            
 Arg Asn Glu Asp Lys Pro Ile Ala Pro Cys Gly Ala Ile Ala Asn Ser
      50                  55                  60                
 Met Phe Asn Asp Thr Leu Glu Leu Phe Leu Ile Gly Asn Asp Ser Tyr
  65                  70                  75                  80
 Pro Ile Pro Ile Ala Leu Lys Lys Lys Gly Ile Ala Trp Trp Thr Asp
                  85                  90                  95    
 Lys Asn Val Lys Phe Arg Asn Pro Pro Gly Gly Asp Asn Leu Glu Glu
             100                 105                 110        
 Arg Phe Lys Gly Thr Thr Lys Pro Val Asn Trp Leu Lys Pro Val Tyr
         115                 120                 125            
 Met Leu Asp Ser Asp Pro Asp Asn Asn Gly Phe Ile Asn Glu Asp Phe
     130                 135                 140                
 Ile Val Trp Met Arg Thr Ala Ala Leu Pro Thr Phe Arg Lys Leu Tyr
 145                 150                 155                 160
 Arg Leu Ile Glu Arg Lys Ser Asp Leu His Pro Thr Leu Pro Ala Gly
                 165                 170                 175    
 Arg Tyr Ser Leu Asn Val Thr Tyr Asn Tyr Pro Val His Tyr Phe Asp
             180                 185                 190        
 Gly Arg Lys Arg Met Ile Leu Ser Thr Ile Ser Trp Met Gly Gly Lys
         195                 200                 205            
 Asn Pro Phe Leu Gly Ile Ala Tyr Ile Ala Val Gly Ser Ile Ser Phe
     210                 215                 220                
 Leu Leu Gly Val Val Leu Leu Val Ile Asn His Lys Tyr Arg Asn Ser
 225                 230                 235                 240
 Ser Asn Thr Ala Asp Ile Thr Ile
                 245            



      <210> 876
      <211> 208
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(208)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 876
 Asn Cys Ser Asn Ser Gly Val Trp Arg Ile Ser His Lys Lys Glu Arg
   1               5                  10                  15    
 Ser Ile Pro Asp Ser Lys Arg Arg Arg Ser Arg Gly Asn Thr Lys Ser
              20                  25                  30        
 Ser Ser Pro Arg Pro Thr Thr Arg Ser Leu Glu Lys Leu Leu Thr Ser
          35                  40                  45            
 Gly Ser Pro Arg Ile Trp Pro Val Arg Met Ser Xaa Leu His Asp Lys
      50                  55                  60                
 Ala Arg Arg Ala Ser Phe Ser Ser Ser Ser Ser Ala Ile Lys Lys Ala
  65                  70                  75                  80
 Phe Ser Ser Ala Ser Arg Ser Ser Asn Glu Ser Val Ser Ser Leu Ser
                  85                  90                  95    
 Asn Ser Ser Leu Glu Gly Gln Ser Lys Ser Met Ser Ile Ser Ser Ser
             100                 105                 110        
 Ser Thr Gly Val Gly Ser Arg Leu Ala Leu Gly Leu Tyr Thr Ser Ser
         115                 120                 125            
 Glu Met Val Lys Gly Ser Ser Phe Ile Leu Ser Ser Ser Ser Leu Gly
     130                 135                 140                
 Gly Ser Ser Tyr Ser Arg Ala Ala Phe Thr Gly Glu Leu Glu Ile Lys
 145                 150                 155                 160
 Gly Ala Glu Met Phe Ser Ser Leu Gly Asn Gly Thr Pro Val Leu Arg
                 165                 170                 175    
 Ala Val Thr Leu Glu Pro Ser Leu Ser Arg Arg Thr Asn Thr Leu Leu
             180                 185                 190        
 Leu Gln Trp Phe Pro Met Cys Asn Trp Arg Leu Arg Arg Val Trp Ile
         195                 200                 205            





      <210> 877
      <211> 127
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(127)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 877
 Thr Arg Arg Asp Ser Arg Cys Lys Gly Thr Trp Leu Leu Ser Val Lys
   1               5                  10                  15    
 Thr Leu Ala Ile Ser Ala Val Lys Ser Gln Lys Ser Lys Ala Ser Glu
              20                  25                  30        
 Cys Arg Phe Thr Asn Arg Ser Ser Ser Thr Ala Val Ile Arg Val Leu
          35                  40                  45            
 Leu Pro Gly Ile Leu Leu Ser Ser Lys Leu Arg Cys Ser Met Val Leu
      50                  55                  60                
 Ala Thr Ala Leu Glu Arg Asp Asp Ser Asp Val Gly Val Thr Ile Ser
  65                  70                  75                  80
 Ser Ile Asn Pro Gln Asp Ser His Phe Ser Cys Leu Leu Leu Leu Arg
                  85                  90                  95    
 Ile Ser Ser Asn Ser Cys Xaa Ile Cys Cys Asn Phe Phe Ala Ile Arg
             100                 105                 110        
 Val His Leu Ala Glu Val Cys Ile Xaa Gln Thr Ser Leu Leu Leu
         115                 120                 125        



      <210> 878
      <211> 163
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(163)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 878
 Ser Ser Gly Leu Gly Cys Ala Gly Thr Arg Asp Ser Gln Leu Ser Ile
   1               5                  10                  15    
 Arg Arg Gly Leu Ser Ser Thr Arg Arg Ser Gly Gly Gly Gly Asp Gly
              20                  25                  30        
 Asp Gly Thr Pro Ala Arg Asp Leu Gln Leu Gly Trp Leu His Leu Leu
          35                  40                  45            
 His Gly Ser Gly Asp Arg Arg Gly Ile Glu Glu Cys Ala Ile Lys Arg
      50                  55                  60                
 Lys Asp Gln Gly Val Asn Gln Lys Lys Lys Lys Lys Arg Thr Ser Lys
  65                  70                  75                  80
 Leu Gly Arg Met Ser Ser Cys Ser Asn Val Cys Gly Ser Arg Gln Ala
                  85                  90                  95    
 Gln Ala Ala Ala Glu Gly Gly Tyr Gln Arg Tyr Gly Val Arg Ser Tyr
             100                 105                 110        
 Leu His Gln Phe Tyr Glu Asp Cys Thr Ala Ser Ile Trp Glu His Glu
         115                 120                 125            
 Asp Asp Phe His Ile Leu Arg Ser Pro Thr Arg Arg Ser Ser Tyr Ile
     130                 135                 140                
 Phe Glu Gly Val Asp Ser Phe Ser Gly Thr Leu Leu Xaa Tyr Leu Ala
 145                 150                 155                 160
 Trp Thr Gly
            



      <210> 879
      <211> 677
      <212> PRT
      <213> Homo sapiens


      <400> 879
 Met Glu Tyr Tyr Ala Ala Ile Lys Lys Asn Glu Ile Met Pro Cys Arg
   1               5                  10                  15    
 Asn Met Asp Gly Asp Gly Asp Tyr Tyr Pro Gln Gln Thr Asn Ala Gly
              20                  25                  30        
 Ile Glu Asn Gln Ile Pro His Val Val Thr Tyr Val Phe Lys Pro Val
          35                  40                  45            
 His Ser Gly Phe Ser Cys Tyr Asp Arg Ser Leu Ser Met Pro Tyr Ile
      50                  55                  60                
 Glu Pro Thr Gln Glu Ala Ile Pro Phe Leu Met Leu Leu Ser Leu Ala
  65                  70                  75                  80
 Phe Ala Gly Pro Ala Ile Thr Ile Met Val Gly Glu Gly Ile Leu Tyr
                  85                  90                  95    
 Cys Cys Leu Ser Lys Arg Arg Asn Gly Val Gly Leu Glu Pro Asn Ile
             100                 105                 110        
 Asn Ala Gly Gly Cys Asn Phe Asn Ser Phe Leu Arg Arg Ala Val Arg
         115                 120                 125            
 Phe Val Glu Asn Asn Val Pro Glu Pro Ala Ser Ala Thr Gly Leu Glu
     130                 135                 140                
 Ser Pro Leu Ser Lys Gly Lys Ser Val His Val Phe Gly Leu Cys Ser
 145                 150                 155                 160
 Thr Ala Leu Ile Thr Asp Ile Ile Gln Leu Ser Thr Gly Tyr Gln Ala
                 165                 170                 175    
 Pro Tyr Phe Leu Thr Val Cys Lys Pro Asn Tyr Thr Ser Leu Asn Val
             180                 185                 190        
 Ser Cys Lys Glu Asn Ser Tyr Ile Val Glu Asp Ile Cys Ser Gly Ser
         195                 200                 205            
 Asp Leu Thr Val Ile Asn Ser Gly Arg Lys Ser Phe Pro Ser Gln His
     210                 215                 220                
 Ala Thr Leu Ala Ala Phe Ala Ala Val Tyr Val Ser Gly Leu Tyr Ala
 225                 230                 235                 240
 Val Gly Asn Phe Leu Pro Ser Asp Glu Ser Met Phe Gln His Arg Asp
                 245                 250                 255    
 Ala Leu Arg Ser Leu Thr Asp Leu Asn Gln Asp Pro Asn Arg Leu Leu
             260                 265                 270        
 Ser Ala Lys Asn Gly Ser Ser Ser Asp Gly Ile Ala His Thr Glu Gly
         275                 280                 285            
 Ile Leu Asn Arg Asn His Arg Asp Ala Ser Ser Leu Thr Asn Leu Lys
     290                 295                 300                
 Arg Ala Asn Ala Asp Val Glu Ile Ile Thr Pro Arg Ser Pro Met Gly
 305                 310                 315                 320
 Lys Glu Asn Met Val Thr Phe Ser Asn Thr Leu Pro Arg Ala Asn Thr
                 325                 330                 335    
 Pro Ser Val Glu Asp Pro Val Arg Arg Asn Ala Ser Ile His Ala Ser
             340                 345                 350        
 Met Asp Ser Ala Arg Ser Lys Gln Leu Leu Thr Gln Trp Lys Asn Lys
         355                 360                 365            
 Asn Glu Ser Arg Lys Leu Ser Leu Gln Val Ile Glu Pro Glu Pro Gly
     370                 375                 380                
 Gln Ser Pro Pro Arg Ser Ile Glu Met Arg Ser Ser Ser Glu Pro Ser
 385                 390                 395                 400
 Arg Val Gly Val Asn Gly Asp His His Gly Pro Gly Asn Gln Tyr Leu
                 405                 410                 415    
 Lys Ile Gln Pro Gly Ala Val Pro Gly Cys Asn Asn Ser Met Pro Gly
             420                 425                 430        
 Gly Pro Arg Val Ser Ile Gln Ser Arg Pro Gly Ser Ser Gln Leu Val
         435                 440                 445            
 His Ile Pro Glu Glu Thr Gln Glu Asn Ile Ser Thr Ser Pro Lys Ser
     450                 455                 460                
 Ser Ser Ala Arg Ala Lys Trp Leu Lys Ala Ala Glu Lys Thr Val Ala
 465                 470                 475                 480
 Cys Asn Arg Ser Asn Ser Gln Pro Arg Ile Met Gln Val Ile Ala Met
                 485                 490                 495    
 Ser Lys Gln Gln Gly Val Leu Gln Ser Ser Pro Lys Asn Thr Glu Gly
             500                 505                 510        
 Ser Thr Val Ser Cys Thr Gly Ser Ile Arg Tyr Lys Thr Leu Thr Asp
         515                 520                 525            
 His Glu Pro Ser Gly Ile Val Arg Val Glu Ala His Pro Glu Asn Asn
     530                 535                 540                
 Arg Pro Ile Ile Gln Ile Pro Ser Thr Glu Gly Glu Gly Ser Gly Ser
 545                 550                 555                 560
 Trp Lys Trp Lys Ala Pro Glu Lys Gly Ser Leu Arg Gln Thr Tyr Glu
                 565                 570                 575    
 Leu Asn Asp Leu Asn Arg Asp Ser Glu Ser Cys Glu Ser Leu Lys Asp
             580                 585                 590        
 Ser Phe Gly Ser Gly Asp Arg Lys Arg Ser Asn Ile Asp Ser Asn Glu
         595                 600                 605            
 His His His His Gly Ile Thr Thr Ile Arg Val Thr Pro Val Glu Gly
     610                 615                 620                
 Ser Glu Ile Gly Ser Glu Thr Leu Ser Ile Ser Ser Ser Arg Asp Ser
 625                 630                 635                 640
 Thr Leu Arg Arg Lys Gly Asn Ile Ile Leu Ile Pro Glu Arg Ser Asn
                 645                 650                 655    
 Ser Pro Glu Asn Thr Arg Asn Ile Phe Tyr Lys Gly Thr Ser Pro Thr
             660                 665                 670        
 Arg Ala Tyr Lys Asp
         675        



      <210> 880
      <211> 350
      <212> PRT
      <213> Homo sapiens


      <400> 880
 Met Arg Lys Asp Ser Glu Gly Cys Glu Ser Asn Cys Asn Arg Ile Gly
   1               5                  10                  15    
 Val Asp Cys Met Phe Lys Gly Leu Arg Glu Ser Val Phe Ala Phe Cys
              20                  25                  30        
 Ser Arg Val Met Arg Lys Cys Met Trp Leu Cys Val Gln Asp Ser Asn
          35                  40                  45            
 Val Phe Val Ser Gln Pro Ser Ser Val Leu Thr Gln Ala Pro Gly Ser
      50                  55                  60                
 Arg Ser Arg Ser Arg Ser Val Asp Ala Leu His Ala Ser Lys Arg Arg
  65                  70                  75                  80
 Ala Trp Gly Ile Val Ala Gly Leu Pro Gly Arg Gly Arg Val Leu Ala
                  85                  90                  95    
 Ala Ala Ala Arg Ser Arg Val Pro Ala Ala Ala Ala Ala Ala Met Val
             100                 105                 110        
 Ser Pro Val Thr Val Val Lys Ser Glu Gly Pro Lys Leu Val Pro Phe
         115                 120                 125            
 Phe Lys Ala Thr Cys Val Tyr Phe Val Leu Trp Leu Pro Ser Ser Ser
     130                 135                 140                
 Pro Ser Trp Val Ser Thr Leu Ile Lys Cys Leu Pro Ile Phe Cys Leu
 145                 150                 155                 160
 Trp Leu Phe Leu Leu Ala His Gly Leu Gly Phe Leu Leu Ala His Pro
                 165                 170                 175    
 Ser Ala Thr Arg Ile Phe Val Gly Leu Val Phe Ser Ala Val Gly Asp
             180                 185                 190        
 Ala Phe Leu Ile Trp Gln Asp Gln Gly Tyr Phe Val His Gly Leu Leu
         195                 200                 205            
 Met Phe Ala Val Thr His Met Phe Tyr Ala Ser Ala Phe Gly Met Gln
     210                 215                 220                
 Pro Leu Ala Leu Arg Thr Gly Leu Val Met Ala Ala Leu Ser Gly Leu
 225                 230                 235                 240
 Cys Tyr Ala Leu Leu Tyr Pro Cys Leu Ser Gly Ala Phe Thr Tyr Leu
                 245                 250                 255    
 Val Gly Val Tyr Val Ala Leu Ile Gly Phe Met Gly Trp Arg Ala Met
             260                 265                 270        
 Ala Gly Leu Arg Leu Ala Gly Ala Asp Trp Arg Trp Thr Glu Leu Ala
         275                 280                 285            
 Ala Gly Ser Gly Ala Leu Phe Phe Ile Ile Ser Asp Leu Thr Ile Ala
     290                 295                 300                
 Leu Asn Lys Phe Cys Phe Pro Val Pro Tyr Ser Arg Ala Leu Ile Met
 305                 310                 315                 320
 Ser Thr Tyr Tyr Ala Ala Gln Met Leu Val Ala Leu Ser Ala Val Glu
                 325                 330                 335    
 Ser Arg Glu Pro Val Glu His Tyr Arg Leu Thr Lys Ala Asn
             340                 345                 350



      <210> 881
      <211> 137
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(137)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 881
 Arg Val Asp Asp Ile His Cys Thr Ala Ala Xaa Gly Arg Ala Thr Pro
   1               5                  10                  15    
 Gly Ser Gly Thr Ser Leu Pro Gly Thr Leu Ser Ser Ser Pro Arg Arg
              20                  25                  30        
 Arg Cys Ser Ser Pro Ser Cys Ser Ala Pro Ala Ser Ala Ala Thr Arg
          35                  40                  45            
 Ser Arg Arg Ala Trp Ser Thr Cys Trp Arg Pro Ser Thr Ala Trp Pro
      50                  55                  60                
 Arg Ser Ser Ala Thr Ser Leu Thr Ala Ser Ser Arg Pro Thr Ala Pro
  65                  70                  75                  80
 Ser Thr Val Ser Thr Arg Thr Cys Arg Pro Pro Gly Ala Thr Ala Gly
                  85                  90                  95    
 Ser Ser Ser Pro Pro Ser Arg Lys Pro Thr Cys Trp Thr Ser Ile Thr
             100                 105                 110        
 Pro Thr Xaa Ser Xaa Ser Cys Met Leu Leu Ser Pro Arg Ser Arg Phe
         115                 120                 125            
 Gln Gly Leu Val Leu Ile Thr Arg Leu
     130                 135        



      <210> 882
      <211> 130
      <212> PRT
      <213> Homo sapiens


      <400> 882
 Asn Ser Thr Phe Ile Cys Tyr Val Ala Ser Ser Ala Ser Ala Phe Leu
   1               5                  10                  15    
 Thr Ala Pro Leu Leu Glu Phe Leu Leu Ala Leu Tyr Phe Leu Phe Ala
              20                  25                  30        
 Asp Ala Met Gln Leu Asn Asp Lys Trp Gln Gly Leu Cys Trp Pro Met
          35                  40                  45            
 Met Asp Phe Leu Arg Cys Val Thr Ala Ala Leu Ile Tyr Phe Ala Ile
      50                  55                  60                
 Ser Ile Thr Ala Ile Ala Lys Tyr Ser Asp Gly Ala Ser Lys Ala Ala
  65                  70                  75                  80
 Gly Val Phe Gly Phe Phe Ala Thr Ile Val Phe Ala Thr Asp Phe Tyr
                  85                  90                  95    
 Leu Ile Phe Asn Asp Val Ala Lys Phe Leu Lys Gln Gly Asp Ser Ala
             100                 105                 110        
 Asp Glu Thr Thr Ala His Lys Thr Glu Glu Glu Asn Ser Asp Ser Asp
         115                 120                 125            
 Ser Asp
     130



      <210> 883
      <211> 62
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(62)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 883
 Arg Thr Lys Gln Thr Leu Xaa Gly Leu Lys Asp Asn Leu Leu Ala Ser
   1               5                  10                  15    
 Gly Thr Ser Ser Leu Thr Ala Thr Lys Gln Leu His Arg Pro Arg Ile
              20                  25                  30        
 Thr Arg Ile Cys Leu Arg Asp Leu Ile Phe Cys Met Glu Gln Glu Arg
          35                  40                  45            
 Glu Met Lys Tyr Ser Arg Ala Leu Tyr Leu Ala Leu Leu Lys
      50                  55                  60        



      <210> 884
      <211> 438
      <212> PRT
      <213> Homo sapiens


      <400> 884
 Pro Ser Ala Pro Glu Val Ile Cys Gly Gly Cys Cys Arg Ala Ala Arg
   1               5                  10                  15    
 Arg Arg Val Asp Leu Pro Arg Ala Lys Arg Arg Ser Pro Pro Pro Pro
              20                  25                  30        
 Ser Pro Pro Pro Pro Pro Pro Pro Pro Ala Ala Gln Ala Pro Pro Pro
          35                  40                  45            
 Pro Val Arg Leu Leu Leu Arg Pro Leu Pro Ala Arg Gly Leu Pro Gly
      50                  55                  60                
 Asp Lys Asp Arg Val Pro Ser Gly Arg Ser His Ala Ala Ala Ala Ser
  65                  70                  75                  80
 Gly Ala Leu Gly Ala Ala Asp Trp Leu Ala Val Gln Val Lys Leu Gln
                  85                  90                  95    
 Met Ala Leu Glu Leu Met Arg Lys Glu Leu Glu Asp Ala Leu Thr Gln
             100                 105                 110        
 Glu Ala Asn Val Gly Lys Lys Thr Val Ile Trp Lys Glu Lys Val Glu
         115                 120                 125            
 Met Gln Arg Gln Arg Phe Arg Leu Glu Phe Glu Lys His Arg Gly Phe
     130                 135                 140                
 Leu Ala Gln Glu Glu Gln Arg Gln Leu Arg Arg Leu Glu Ala Glu Glu
 145                 150                 155                 160
 Arg Ala Thr Leu Gln Arg Leu Arg Glu Ser Lys Ser Arg Leu Val Gln
                 165                 170                 175    
 Gln Ser Lys Ala Leu Lys Glu Leu Ala Asp Glu Leu Gln Glu Arg Cys
             180                 185                 190        
 Gln Arg Pro Ala Leu Gly Leu Leu Glu Gly Val Arg Gly Val Leu Ser
         195                 200                 205            
 Arg Ser Lys Ala Val Thr Arg Leu Glu Ala Glu Asn Ile Pro Met Glu
     210                 215                 220                
 Leu Lys Thr Ala Cys Cys Ile Pro Gly Arg Arg Glu Leu Leu Arg Lys
 225                 230                 235                 240
 Phe Gln Val Asp Val Lys Leu Asp Pro Ala Thr Ala His Pro Ser Leu
                 245                 250                 255    
 Leu Leu Thr Ala Asp Leu Arg Ser Val Gln Asp Gly Glu Pro Trp Arg
             260                 265                 270        
 Asp Val Pro Asn Asn Pro Glu Arg Phe Asp Thr Trp Pro Cys Ile Leu
         275                 280                 285            
 Gly Leu Gln Ser Phe Ser Ser Gly Arg His Tyr Trp Glu Val Leu Val
     290                 295                 300                
 Gly Glu Gly Ala Glu Trp Gly Leu Gly Val Cys Gln Asp Thr Leu Pro
 305                 310                 315                 320
 Arg Lys Gly Glu Thr Thr Pro Ser Pro Glu Asn Gly Val Trp Ala Leu
                 325                 330                 335    
 Trp Leu Leu Lys Gly Asn Glu Tyr Met Val Leu Ala Ser Pro Ser Val
             340                 345                 350        
 Pro Leu Leu Gln Leu Glu Ser Pro Arg Cys Ile Gly Ile Phe Leu Asp
         355                 360                 365            
 Tyr Glu Ala Gly Glu Ile Ser Phe Tyr Asn Val Thr Asp Gly Ser Tyr
     370                 375                 380                
 Ile Tyr Thr Phe Asn Gln Leu Phe Ser Gly Leu Leu Arg Pro Tyr Phe
 385                 390                 395                 400
 Phe Ile Cys Asp Ala Thr Pro Leu Ile Leu Pro Pro Thr Thr Ile Ala
                 405                 410                 415    
 Gly Ser Gly Asn Trp Ala Ser Arg Asp His Leu Asp Pro Ala Ser Asp
             420                 425                 430        
 Val Arg Asp Asp His Leu
         435            



      <210> 885
      <211> 400
      <212> PRT
      <213> Homo sapiens


      <400> 885
 Lys Val Leu Ser Ile Arg Glu Pro Ala His Ser Thr Ala Arg Lys Ala
   1               5                  10                  15    
 Ser Glu Pro Ser Gln Pro Ser Gln Pro Ser Gln Pro Gly Gly His Leu
              20                  25                  30        
 Ile Ala Arg Leu Arg Thr Met Asp Leu His Leu Phe Asp Tyr Ser Glu
          35                  40                  45            
 Pro Gly Asn Phe Ser Asp Ile Ser Trp Pro Cys Asn Ser Ser Asp Cys
      50                  55                  60                
 Ile Val Val Asp Thr Val Met Cys Pro Asn Met Pro Asn Lys Ser Val
  65                  70                  75                  80
 Leu Leu Tyr Thr Leu Ser Phe Ile Tyr Ile Phe Ile Phe Val Ile Gly
                  85                  90                  95    
 Met Ile Ala Asn Ser Val Val Val Trp Val Asn Ile Gln Ala Lys Thr
             100                 105                 110        
 Thr Gly Tyr Asp Thr His Cys Tyr Ile Leu Asn Leu Ala Ile Ala Asp
         115                 120                 125            
 Leu Trp Val Val Leu Thr Ile Pro Val Trp Val Val Ser Leu Val Gln
     130                 135                 140                
 His Asn Gln Trp Pro Met Gly Glu Leu Thr Cys Lys Val Thr His Leu
 145                 150                 155                 160
 Ile Phe Ser Ile Asn Leu Phe Gly Ser Ile Phe Phe Leu Thr Cys Met
                 165                 170                 175    
 Ser Val Asp Arg Tyr Leu Ser Ile Thr Tyr Phe Thr Asn Thr Pro Ser
             180                 185                 190        
 Ser Arg Lys Lys Met Val Arg Arg Val Val Cys Ile Leu Val Trp Leu
         195                 200                 205            
 Leu Ala Phe Cys Val Ser Leu Pro Asp Thr Tyr Tyr Leu Lys Thr Val
     210                 215                 220                
 Thr Ser Ala Ser Asn Asn Glu Thr Tyr Cys Arg Ser Phe Tyr Pro Glu
 225                 230                 235                 240
 His Ser Ile Lys Glu Trp Leu Ile Gly Met Glu Leu Val Ser Val Val
                 245                 250                 255    
 Leu Gly Phe Ala Val Pro Phe Ser Ile Ile Ala Val Phe Tyr Phe Leu
             260                 265                 270        
 Leu Ala Arg Ala Ile Ser Ala Ser Ser Asp Gln Glu Lys His Ser Ser
         275                 280                 285            
 Arg Lys Ile Ile Phe Ser Tyr Val Val Val Phe Leu Val Cys Trp Leu
     290                 295                 300                
 Pro Tyr His Val Ala Val Leu Leu Asp Ile Phe Ser Ile Leu His Tyr
 305                 310                 315                 320
 Ile Pro Phe Thr Cys Arg Leu Glu His Ala Leu Phe Thr Ala Leu His
                 325                 330                 335    
 Val Thr Gln Cys Leu Ser Leu Val His Cys Cys Val Asn Pro Val Leu
             340                 345                 350        
 Tyr Ser Phe Ile Asn Arg Asn Tyr Arg Tyr Glu Leu Met Lys Ala Phe
         355                 360                 365            
 Ile Phe Lys Tyr Ser Ala Lys Thr Gly Leu Thr Lys Leu Ile Asp Ala
     370                 375                 380                
 Ser Arg Val Ser Glu Thr Glu Tyr Ser Ala Leu Glu Gln Ser Thr Lys
 385                 390                 395                 400





      <210> 886
      <211> 238
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(238)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 886
 Ala Val Ala Trp Thr Ala Asp Ser Glu Pro Leu Ser Ala Gly Ser Ala
   1               5                  10                  15    
 Ser Arg Ala Arg Ser Arg Gly Ser Ser Xaa Ala Pro Ala Ala Ala Thr
              20                  25                  30        
 Ala Gln Cys Ala Ala Arg Ile Ser Pro Ala Ser Ser Ala Gly Ser Ala
          35                  40                  45            
 Arg Gly Ala Pro Gly Ala Val Ser Ser Ala Thr Ser Ser Thr Arg Ser
      50                  55                  60                
 Trp Arg Ser Ala Pro Arg Thr His Cys Ser Gly Arg Pro Ser Pro Xaa
  65                  70                  75                  80
 Arg Ser Ser Arg Arg Ser Arg Leu Leu Pro Xaa Phe Trp Ala Arg Ser
                  85                  90                  95    
 Ser Trp Leu Pro Ala Ser Pro Gly Ser Ser Gly Pro His Ser Ala Leu
             100                 105                 110        
 Gln Pro Ser Gly Asn Asp Arg Ile Cys Ser Phe Arg Ser Ala Thr Ala
         115                 120                 125            
 Cys Met Ala Ser Trp Met Ser Ser Ala Xaa Ala Ser Ser Ser Met Lys
     130                 135                 140                
 Ala Pro Leu Ser Thr Ala Ser Ser Ser Ala Gly Arg Gln Xaa Thr Ser
 145                 150                 155                 160
 Ser Gly Arg Ser Xaa Ile Met Thr Arg Pro Arg Thr Xaa Glu Glu Met
                 165                 170                 175    
 Gln Gly Glu Gly Arg Gln Gly Ser Gln Ala Pro Gly Thr His Gly Arg
             180                 185                 190        
 Ala Pro Pro Leu Gly Pro Arg Ala Ala Pro Gln Leu Pro Ser Ala Cys
         195                 200                 205            
 Gly Arg Ser Cys Leu Ser Ala Ala Val Ile Gln Ser Cys Thr Ser Leu
     210                 215                 220                
 Gly Ser Cys Gly His Gln Met Pro Val Pro Ala Pro Ile Leu
 225                 230                 235            



      <210> 887
      <211> 92
      <212> PRT
      <213> Homo sapiens


      <400> 887
 Asn Ser Ser Glu Ser Ser Leu Arg Gly Asn Ile Ala Gly Val Ser Ile
   1               5                  10                  15    
 Asp Phe Phe Phe Phe Lys Tyr Ile Arg Leu Trp Phe Ser Phe Ile Lys
              20                  25                  30        
 Ser Pro Asp Phe His Cys Val Asn Glu Glu Thr Tyr Gln Gly Thr Asp
          35                  40                  45            
 Glu Phe Gln Cys Gln Asp Gly Gln Asn Glu Val Lys Ile Gln Ser Ala
      50                  55                  60                
 Arg Leu Trp Glu Gly Val Leu His Ala Gln Tyr Glu Glu Lys His Cys
  65                  70                  75                  80
 Val Ala Arg Gly Leu Tyr His Gln Arg Lys Ser Pro
                  85                  90        



      <210> 888
      <211> 109
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(109)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 888
 Asp Val Lys Ser Lys Ser Phe Phe Phe Phe Leu Arg Trp Ser Leu Asn
   1               5                  10                  15    
 Pro Phe Ala Gln Ala Gly Val Xaa Trp His Asp Leu Ser Ser Leu Gln
              20                  25                  30        
 Pro Leu Pro His Arg Phe Lys Gln Phe Ser Cys Leu Ser Leu Leu Ser
          35                  40                  45            
 Ser Xaa Asp Tyr Arg Arg Val Pro Pro Xaa Leu Ala Asn Phe Leu Tyr
      50                  55                  60                
 Phe Xaa Xaa Arg Gln Gly Phe Thr Met Leu Ala Arg Leu Ala Ser Asn
  65                  70                  75                  80
 Ser Xaa Pro His Asp Pro Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile
                  85                  90                  95    
 Thr Gly Met Ser His Arg Thr Gln Lys Lys Gln Ile Ser
             100                 105                



      <210> 889
      <211> 198
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(198)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 889
 Xaa Xaa Pro Asp Ala Leu Ser Thr Val Ala Glu Xaa Pro Gly Arg Pro
   1               5                  10                  15    
 Thr Arg Pro Pro Thr Arg Thr Ala Ala Pro Trp Pro Arg Pro Gly Cys
              20                  25                  30        
 Ser Ser Ala Ser Ala Pro Pro Thr Pro Ala Ser Ala Pro Trp Pro Ala
          35                  40                  45            
 Ser Pro Ser Ser Ser Ser Gly Arg Trp Ser Thr Asp Ser Arg Gly Pro
      50                  55                  60                
 Arg Pro Trp Glu Gly Ser Gln Gly Cys Trp His Cys Gly Ser Trp Xaa
  65                  70                  75                  80
 Arg Thr Xaa Cys Thr Cys Lys Ile Ile Gly Gly Pro Gly Ser Arg Gly
                  85                  90                  95    
 Cys Ala Ala Ser Ser Ser Trp Ala Ser Ser Ser Arg Pro Ser Pro Ser
             100                 105                 110        
 Leu Pro Ser Ala Pro Ser Ser Cys Trp Pro Ser Pro Gly Ile Arg Ala
         115                 120                 125            
 Ser Gln Thr Pro Pro Ala Thr Thr Ser Pro Ala Ser Gly Ala Ser Phe
     130                 135                 140                
 Pro Ser Ser Gly Pro Ser Cys Ser Ala Ser Met Pro Thr Ala Thr Gly
 145                 150                 155                 160
 Leu Thr Leu Leu Thr Ser Ala Ser Ser Ala Ile Ser Asp Pro Gly Gly
                 165                 170                 175    
 Ser Val Tyr Ala Xaa Ser Gly Met Val His Gln Ser Gly Lys Glu Pro
             180                 185                 190        
 Ser Thr Val Tyr Thr Ser
         195            



      <210> 890
      <211> 420
      <212> PRT
      <213> Homo sapiens


      <400> 890
 Met Gly Leu Phe Glu Gly Thr Phe Arg Glu Glu Gln Lys Cys Thr Tyr
   1               5                  10                  15    
 Gln Phe Leu Met Gln Gly Phe Ile Cys Lys Gln Thr Asp Gln Val Val
              20                  25                  30        
 Leu Ile Leu Asp Ser Ala Asp Ala Ile Trp Ala Ile Gln Lys Leu Tyr
          35                  40                  45            
 Pro Val Val Ser Val Thr Ser Gly Phe Val Asp Val Phe Ser Ser Val
      50                  55                  60                
 Asn Ala Asn Ile Pro Cys Ser Thr Ser Gly Ser Val Ser Thr Phe Tyr
  65                  70                  75                  80
 Ser Ile Leu Pro Ile Arg Gln Ile Thr Lys Val Cys Phe Met Asp Gln
                  85                  90                  95    
 Thr Pro Gln Val Leu Arg Phe Phe Leu Leu Gly Asn Lys Ser Thr Ser
             100                 105                 110        
 Lys Leu Leu Leu Ala Val Phe Tyr His Glu Leu Gln Ser Pro His Val
         115                 120                 125            
 Phe Leu Gly Glu Ser Phe Ile Pro Pro Thr Leu Val Gln Ser Ala Ser
     130                 135                 140                
 Leu Leu Leu Asn Glu Ser Ile Gly Ala Asn Tyr Phe Asn Ile Met Asp
 145                 150                 155                 160
 Asn Leu Leu Tyr Val Val Leu Gln Gly Glu Glu Pro Ile Glu Ile Arg
                 165                 170                 175    
 Ser Gly Val Ser Ile His Leu Ala Leu Thr Val Met Val Ser Val Leu
             180                 185                 190        
 Glu Lys Gly Trp Glu Ile Val Ile Leu Glu Arg Leu Thr Asn Phe Leu
         195                 200                 205            
 Gln Ile Gly Gln Asn Gln Ile Arg Phe Ile His Glu Met Pro Gly His
     210                 215                 220                
 Glu Glu Thr Leu Lys Ala Ile Ala Asp Ser Arg Ala Lys Arg Lys Arg
 225                 230                 235                 240
 Asn Cys Pro Thr Val Thr Cys Thr Ser His Tyr Arg Arg Val Gly Gln
                 245                 250                 255    
 Arg Arg Pro Leu Met Met Glu Met Asn Ser His Arg Ala Ser Pro Pro
             260                 265                 270        
 Met Thr Val Glu Thr Ile Ser Lys Val Ile Val Ile Glu Ile Gly Asp
         275                 280                 285            
 Ser Pro Thr Val Arg Ser Thr Gly Met Ile Ser Ser Leu Ser Ser Asn
     290                 295                 300                
 Lys Leu Gln Asn Leu Ala His Arg Val Ile Thr Ala Gln Gln Thr Gly
 305                 310                 315                 320
 Val Leu Glu Asn Val Leu Asn Met Thr Ile Gly Ala Leu Leu Val Thr
                 325                 330                 335    
 Gln Ser Lys Gly Val Ile Gly Tyr Gly Asn Thr Ser Ser Phe Lys Thr
             340                 345                 350        
 Gly Asn Leu Ile Tyr Ile Arg Pro Tyr Ala Leu Ser Ile Leu Val Gln
         355                 360                 365            
 Pro Ser Asp Gly Glu Val Gly Asn Glu Leu Pro Val Gln Pro Gln Leu
     370                 375                 380                
 Val Phe Leu Asp Glu Gln Asn Arg Arg Val Glu Ser Leu Gly Pro Pro
 385                 390                 395                 400
 Ser Glu Pro Trp Thr Ile Ser Ala Ser Leu Glu Gly Ala Ser Asp Ser
                 405                 410                 415    
 Val Leu Lys Gly
             420



      <210> 891
      <211> 564
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(564)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 891
 Phe Val Arg Glu Ile Arg Gly Pro Ala Val Pro Arg Leu Thr Ser Ala
   1               5                  10                  15    
 Glu Asp Arg His Arg His Gly Pro His Ala His Ser Pro Glu Leu Gln
              20                  25                  30        
 Arg Thr Gly Arg Asp Tyr Ser Leu Asp Tyr Leu Pro Phe Arg Leu Trp
          35                  40                  45            
 Val Gly Ile Trp Val Ala Thr Phe Cys Leu Val Leu Val Ala Thr Glu
      50                  55                  60                
 Ala Ser Val Leu Val Arg Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe
  65                  70                  75                  80
 Cys Ala Leu Ile Ser Leu Ile Phe Ile Tyr Asp Ala Val Gly Lys Met
                  85                  90                  95    
 Leu Asn Leu Thr His Thr Tyr Pro Ile Gln Lys Pro Gly Ser Ser Ala
             100                 105                 110        
 Tyr Gly Cys Leu Cys Gln Tyr Pro Gly Pro Gly Gly Asn Glu Ser Gln
         115                 120                 125            
 Trp Ile Arg Thr Arg Pro Lys Asp Arg Asp Asp Ile Val Ser Met Asp
     130                 135                 140                
 Leu Gly Leu Ile Asn Ala Ser Leu Leu Pro Pro Pro Glu Cys Thr Arg
 145                 150                 155                 160
 Gln Gly Gly His Pro Arg Gly Pro Gly Cys His Thr Val Pro Asp Ile
                 165                 170                 175    
 Ala Phe Phe Ser Leu Leu Leu Phe Leu Thr Ser Phe Phe Phe Ala Met
             180                 185                 190        
 Ala Leu Lys Cys Val Lys Thr Ser Arg Phe Phe Pro Ser Val Val Arg
         195                 200                 205            
 Lys Gly Leu Ser Asp Phe Ser Ser Val Leu Ala Ile Leu Leu Gly Cys
     210                 215                 220                
 Gly Leu Asp Ala Phe Leu Gly Leu Ala Thr Pro Lys Leu Met Val Pro
 225                 230                 235                 240
 Arg Glu Phe Lys Pro Thr Leu Pro Gly Arg Gly Trp Leu Val Ser Pro
                 245                 250                 255    
 Phe Gly Ala Asn Pro Trp Trp Trp Ser Val Ala Ala Ala Leu Pro Ala
             260                 265                 270        
 Leu Leu Leu Ser Ile Leu Ile Phe Met Asp Gln Gln Ile Thr Ala Val
         275                 280                 285            
 Ile Leu Asn Arg Met Glu Tyr Arg Leu Gln Lys Gly Ala Gly Phe His
     290                 295                 300                
 Leu Asp Leu Phe Trp Val Ala Val Leu Met Leu Leu Thr Ser Ala Leu
 305                 310                 315                 320
 Gly Leu Pro Trp Tyr Val Ser Ala Thr Val Ile Ser Leu Ala His Met
                 325                 330                 335    
 Asp Ser Leu Arg Arg Glu Ser Arg Ala Cys Ala Pro Gly Glu Arg Pro
             340                 345                 350        
 Asn Phe Leu Gly Ile Arg Glu Gln Arg Leu Thr Gly Leu Val Val Phe
         355                 360                 365            
 Ile Leu Thr Gly Ala Ser Ile Phe Leu Ala Pro Val Leu Lys Phe Ile
     370                 375                 380                
 Pro Met Pro Val Leu Tyr Gly Ile Phe Leu Tyr Met Gly Val Ala Ala
 385                 390                 395                 400
 Leu Ser Ser Ile Gln Phe Thr Asn Arg Val Lys Leu Leu Leu Met Pro
                 405                 410                 415    
 Ala Lys His Gln Pro Asp Leu Leu Leu Leu Arg His Val Pro Leu Thr
             420                 425                 430        
 Arg Val His Leu Phe Thr Ala Ile Ser Phe Ala Cys Leu Gly Leu Leu
         435                 440                 445            
 Trp Ile Ile Lys Ser Thr Pro Ala Ala Ile Ile Phe Pro Leu Met Leu
     450                 455                 460                
 Leu Gly Leu Val Gly Val Arg Lys Ala Leu Glu Arg Val Phe Ser Pro
 465                 470                 475                 480
 Gln Glu Leu Leu Trp Leu Asp Glu Leu Met Pro Glu Glu Glu Arg Ser
                 485                 490                 495    
 Ile Pro Glu Lys Gly Leu Glu Pro Glu His Ser Phe Ser Gly Ser Asp
             500                 505                 510        
 Ser Glu Asp Ser Glu Leu Met Tyr Gln Pro Lys Ala Pro Glu Ile Asn
         515                 520                 525            
 Ile Ser Val Asn Xaa Leu Glu Xaa Glu Leu Asp Pro Tyr Leu Ser Tyr
     530                 535                 540                
 Pro Glu Ala Trp Val Leu Cys Leu Arg Val Pro Leu Pro Ile Pro Arg
 545                 550                 555                 560
 Pro Arg Arg Lys
                



      <210> 892
      <211> 151
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(151)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 892
 Ala Ala Pro Met Glu Leu Ile Cys Trp Ser Gly Gly Trp Gly Leu Pro
   1               5                  10                  15    
 Ser Val Asp Leu Asp Ser Leu Ala Val Leu Thr Tyr Ala Arg Phe Thr
              20                  25                  30        
 Gly Ala Pro Leu Lys Val His Lys Ile Ile Asn Pro Trp Xaa Ser Pro
          35                  40                  45            
 Ser Gly Thr Leu Pro Ala Leu Arg Thr Ser His Gly Glu Val Ile Ser
      50                  55                  60                
 Val Pro His Lys Ile Ile Thr His Leu Leu Lys Glu Lys Tyr Asn Ala
  65                  70                  75                  80
 Asp Tyr Asp Leu Ser Ala Arg Gln Gly Ala Asp Thr Leu Ala Phe Met
                  85                  90                  95    
 Ser Leu Leu Glu Glu Lys Leu Leu Pro Gly Leu Val His Thr Phe Trp
             100                 105                 110        
 Ile Asp Thr Lys Asn Tyr Leu Glu Val Thr Arg Lys Trp Tyr Ala Glu
         115                 120                 125            
 Ala Met Pro Phe Ser Leu Asn Phe Phe Leu Pro Gly Arg Met Gln Arg
     130                 135                 140                
 Gln Tyr Met Xaa Arg Leu Pro
 145                 150    



      <210> 893
      <211> 151
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(151)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 893
 Ala Ala Pro Met Glu Leu Ile Cys Trp Ser Gly Gly Trp Gly Leu Pro
   1               5                  10                  15    
 Ser Val Asp Leu Asp Ser Leu Ala Val Leu Thr Tyr Ala Arg Phe Thr
              20                  25                  30        
 Gly Ala Pro Leu Lys Val His Lys Ile Ile Asn Pro Trp Xaa Ser Pro
          35                  40                  45            
 Ser Gly Thr Leu Pro Ala Leu Arg Thr Ser His Gly Glu Val Ile Ser
      50                  55                  60                
 Val Pro His Lys Ile Ile Thr His Leu Leu Lys Glu Lys Tyr Asn Ala
  65                  70                  75                  80
 Asp Tyr Asp Leu Ser Ala Arg Gln Gly Ala Asp Thr Leu Ala Phe Met
                  85                  90                  95    
 Ser Leu Leu Glu Glu Lys Leu Leu Pro Gly Leu Val His Thr Phe Trp
             100                 105                 110        
 Ile Asp Thr Lys Asn Tyr Leu Glu Val Thr Arg Lys Trp Tyr Ala Glu
         115                 120                 125            
 Ala Met Pro Phe Ser Leu Asn Phe Phe Leu Pro Gly Arg Met Gln Arg
     130                 135                 140                
 Gln Tyr Met Xaa Arg Leu Pro
 145                 150    



      <210> 894
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 894
 His Met Ile Cys Ala Gly Thr Glu Lys Val Asp Asp Asp Ala Leu Leu
   1               5                  10                  15    
 Val Phe Trp Asp Ala Arg Met Asn Ser Glu Ser Leu Ser Thr Thr Lys
              20                  25                  30        
 Asp Ser Leu Gly Ala Tyr Ser Glu Thr His Ser Asp Asp Val Thr Gln
          35                  40                  45            
 Val Arg Phe His Pro Ser Asn Pro Asn Met Val Val Ser Gly Ser Ser
      50                  55                  60                
 Asp Gly Leu Val Asn Val Phe Asp Ile Asn Ile Asp Asn Glu Glu Asp
  65                  70                  75                  80
 Ala Leu Val Thr Thr Cys Asn Ser Ile Ser Ser Val Ser Cys Ile Gly
                  85                  90                  95    
 Trp Ser Gly Lys Gly Tyr Lys Gln Ile Tyr Cys Met Thr His Asp Glu
             100                 105                 110        
 Gly Phe Tyr Trp Trp Asp Leu Asn His Leu Asp Thr Asp Glu Pro Val
         115                 120                 125            
 Thr Arg Leu Asn Ile Gln Asp Val Arg
     130                 135        



      <210> 895
      <211> 1113
      <212> PRT
      <213> Homo sapiens


      <400> 895
 Asn Gln Glu Ser Leu Val Gln Cys Gln Gly Pro Ala Ile Ile Gly Ala
   1               5                  10                  15    
 Leu Leu Arg Lys Val Pro Ser Trp Ala Met Asp Met Asn Val Leu Met
              20                  25                  30        
 Ser Ala Gln Leu Leu Met Glu Gln Val Ala Ala Glu Gly Ser Gly Pro
          35                  40                  45            
 Leu Leu Tyr Leu Leu Tyr Gln His Leu Leu Phe Asn Phe His Leu Trp
      50                  55                  60                
 Thr Leu Ser Asp Phe Ala Val Arg Leu Gly His Ile Gln Tyr Met Ser
  65                  70                  75                  80
 Ser Ile Val Arg Glu His Arg Gln Lys Leu Arg Lys Lys Tyr Gly Val
                  85                  90                  95    
 Gln Phe Ile Leu Asp Ala Leu Arg Thr His Tyr Ser Pro Gln Arg Glu
             100                 105                 110        
 Arg Pro Leu Ala Ala Asp Asp Leu Arg Thr Val Gln Thr Ser Leu Leu
         115                 120                 125            
 Gly Leu Ala Arg Glu Phe Leu Val Arg Ser Leu Ser Ala Asp Asp Val
     130                 135                 140                
 Gln Val Thr Gln Thr Met Leu Ser Phe Leu Ala Ala Thr Gly Asp Asp
 145                 150                 155                 160
 Gly Gln Ala Val Gly Ala Leu Asp Leu Leu Leu Ala Leu Leu His Gly
                 165                 170                 175    
 Ser Leu Val Gln Glu Ser Leu Ala Val Phe Leu Leu Glu Pro Gly Asn
             180                 185                 190        
 Leu Glu Val Leu Leu Ala Leu Leu Val Arg Pro Gly Ser Leu Pro Leu
         195                 200                 205            
 Leu Pro Asp Arg Val Cys Lys Ile Leu Arg Arg Leu Gln Gln Asn Glu
     210                 215                 220                
 Arg Leu Pro Glu Arg Ser Arg Gln Arg Leu Arg Leu Arg Glu Cys Gly
 225                 230                 235                 240
 Leu Gln Gly Leu Val Ala Cys Leu Pro Glu Gly Thr Val Ser Pro Gln
                 245                 250                 255    
 Leu Cys Gln Gly Leu Tyr Lys Leu Phe Leu Gly Ala Asp Cys Leu Asn
             260                 265                 270        
 Leu Ser Asp Leu Leu Ala Val Val Gln Leu Ser Leu Gln Ala Asp Leu
         275                 280                 285            
 Ser Val Arg Leu Asp Ile Cys Arg Gln Leu Phe His Leu Ile Tyr Gly
     290                 295                 300                
 Gln Pro Asp Val Val Arg Leu Leu Ala Arg Gln Ala Gly Trp Gln Asp
 305                 310                 315                 320
 Val Leu Thr Arg Leu Tyr Val Leu Glu Ala Ala Thr Ala Gly Ser Pro
                 325                 330                 335    
 Pro Pro Ser Ser Pro Glu Ser Pro Thr Ser Pro Lys Pro Ala Pro Pro
             340                 345                 350        
 Lys Pro Pro Thr Glu Ser Pro Ala Glu Pro Ser Asp Val Phe Leu Pro
         355                 360                 365            
 Ser Glu Ala Pro Cys Pro Asp Pro Asp Gly Phe Tyr His Ala Leu Ser
     370                 375                 380                
 Pro Phe Cys Thr Pro Phe Asp Leu Gly Leu Glu Arg Ser Ser Val Gly
 385                 390                 395                 400
 Ser Gly Asn Thr Ala Gly Gly Gly Gly Ser Ser Gly Thr Leu Thr Pro
                 405                 410                 415    
 Ala Ser Gln Pro Gly Thr Pro Ser Pro Leu Asp Gly Pro Arg Pro Phe
             420                 425                 430        
 Pro Ala Ala Pro Gly Arg His Ser Ser Ser Leu Ser Asn Val Leu Glu
         435                 440                 445            
 Asp Gly Ser Leu Pro Glu Pro Thr Ile Ser Gly Asp Asp Thr Ser Asn
     450                 455                 460                
 Thr Ser Asn Pro Gln Gln Thr Ser Glu Glu Glu Leu Cys Asn Leu Leu
 465                 470                 475                 480
 Thr Asn Val Leu Phe Ser Val Thr Trp Arg Gly Val Glu Gly Ser Asp
                 485                 490                 495    
 Glu Ala Ala Trp Arg Glu Arg Gly Gln Val Phe Ser Val Leu Thr Gln
             500                 505                 510        
 Leu Gly Ala Ser Ala Thr Leu Val Arg Pro Pro Asp Cys Ile Lys Arg
         515                 520                 525            
 Ser Leu Leu Glu Met Met Leu Glu Ser Ala Leu Thr Asp Ile Lys Glu
     530                 535                 540                
 Ala Pro Val Gly Val Leu Ala Ser Leu Thr Gln Gln Ala Leu Trp Leu
 545                 550                 555                 560
 Leu Arg Leu Leu Gln Asp Phe Leu Cys Ala Glu Gly His Gly Asn Gln
                 565                 570                 575    
 Glu Leu Trp Ser Glu Lys Leu Phe Glu Gly Val Cys Ser Leu Leu Asp
             580                 585                 590        
 Arg Leu Gly Ala Trp Pro His Leu Ala Asn Gly Thr Ala Asp Leu Arg
         595                 600                 605            
 Glu Met Ala Gln Ile Gly Leu Arg Leu Val Leu Gly Tyr Ile Leu Leu
     610                 615                 620                
 Glu Asp Pro Gln Leu His Ala Gln Ala Tyr Val Arg Leu His Met Leu
 625                 630                 635                 640
 Leu Gln Thr Ala Val Pro Ala Arg Arg Glu Glu Ala Cys Tyr Val Leu
                 645                 650                 655    
 Ser Lys Leu Glu Ala Ala Leu Gly Arg Val Leu Asn Thr Ser Ser Leu
             660                 665                 670        
 Glu Ser Ala Thr Asp Glu Ala Gly Ser Pro Leu Ala Ala Ala Ala Ala
         675                 680                 685            
 Ala Ala Ala Ala Glu Arg Cys Ser Trp Leu Val Pro Leu Val Arg Thr
     690                 695                 700                
 Leu Leu Asp Arg Ala Tyr Glu Pro Leu Gly Leu Gln Trp Gly Leu Pro
 705                 710                 715                 720
 Ser Leu Pro Pro Thr Asn Gly Ser Pro Thr Phe Phe Glu Asp Phe Gln
                 725                 730                 735    
 Ala Phe Cys Ala Thr Pro Glu Trp Arg His Phe Ile Asp Lys Gln Val
             740                 745                 750        
 Gln Pro Thr Met Ser Gln Phe Glu Met Asp Thr Tyr Ala Lys Ser His
         755                 760                 765            
 Asp Leu Met Ser Gly Phe Trp Asn Ala Cys Tyr Asp Met Leu Met Ser
     770                 775                 780                
 Ser Gly Gln Arg Arg Gln Trp Glu Arg Ala Gln Ser Arg Arg Ala Phe
 785                 790                 795                 800
 Gln Glu Leu Val Leu Glu Pro Ala Gln Arg Arg Ala Arg Leu Glu Gly
                 805                 810                 815    
 Leu Arg Tyr Thr Ala Val Leu Lys Gln Gln Ala Thr Gln His Ser Met
             820                 825                 830        
 Ala Leu Leu His Trp Gly Ala Leu Trp Arg Gln Leu Ala Ser Pro Cys
         835                 840                 845            
 Gly Ala Trp Ala Leu Arg Asp Thr Pro Ile Pro Arg Trp Lys Leu Ser
     850                 855                 860                
 Ser Ala Glu Thr Tyr Ser Arg Met Arg Leu Lys Leu Val Pro Asn His
 865                 870                 875                 880
 His Phe Asp Pro His Leu Glu Ala Ser Ala Leu Arg Asp Asn Leu Gly
                 885                 890                 895    
 Glu Val Pro Leu Thr Pro Thr Glu Glu Ala Ser Leu Pro Leu Ala Val
             900                 905                 910        
 Thr Lys Glu Ala Lys Val Ser Thr Pro Pro Glu Leu Leu Gln Glu Asp
         915                 920                 925            
 Gln Leu Gly Glu Asp Glu Leu Ala Glu Leu Glu Thr Pro Met Glu Ala
     930                 935                 940                
 Ala Glu Leu Asp Glu Gln Arg Glu Lys Leu Val Leu Ser Ala Glu Cys
 945                 950                 955                 960
 Gln Leu Val Thr Val Val Ala Val Val Pro Gly Leu Leu Glu Val Thr
                 965                 970                 975    
 Thr Gln Asn Val Tyr Phe Tyr Asp Gly Ser Thr Glu Arg Val Glu Thr
             980                 985                 990        
 Glu Glu Gly Ile Gly Tyr Asp Phe Arg Arg Pro Leu Ala Gln Leu Arg
         995                1000                1005            
 Glu Val His Leu Arg Arg Phe Asn Leu Arg Arg Ser Ala Leu Glu Leu
    1010                1015                1020                
 Phe Phe Ile Asp Gln Ala Asn Tyr Phe Leu Asn Phe Pro Cys Lys Val
1025                1030                1035                1040
 Gly Thr Thr Pro Val Ser Ser Pro Ser Gln Thr Pro Arg Pro Gln Pro
                1045                1050                1055    
 Gly Pro Ile Pro Pro His Thr Gln Val Arg Asn Gln Val Tyr Ser Trp
            1060                1065                1070        
 Leu Leu Arg Leu Arg Pro Pro Ser Gln Gly Tyr Leu Ser Ser Arg Ser
        1075                1080                1085            
 Pro Gln Glu Met Leu Arg Ala Ser Gly Leu Thr Gln Val Arg Ala Leu
    1090                1095                1100                
 Gly Val Arg Asp Val Lys Ser Gly Pro
1105                1110            



      <210> 896
      <211> 223
      <212> PRT
      <213> Homo sapiens


      <400> 896
 Pro Ser Ser Leu Leu Lys Lys Arg Phe Val Ala Leu Pro Thr Asn Thr
   1               5                  10                  15    
 Thr Ser Ser Arg Pro Leu Thr Glu Cys Cys Ser Asp Ala Gly Asp Ser
              20                  25                  30        
 Pro Leu Lys Pro Val Ser Cys Pro Lys Ser Lys Ala Ser Asp Lys Arg
          35                  40                  45            
 Ser Leu Leu Pro His His Ile Arg Gln Ile Tyr Asp Glu Leu Phe Gln
      50                  55                  60                
 Ile His Val Lys Leu Gln Cys Glu Thr Ala Ala Gln Gln Lys Phe Ala
  65                  70                  75                  80
 Glu Glu Leu Gln Lys Arg Glu Arg Phe Leu Leu Glu Arg Glu Gln Leu
                  85                  90                  95    
 Leu Phe Arg His Glu Asn Ala Leu Ser Lys Ile Lys Gly Val Glu Glu
             100                 105                 110        
 Glu Val Leu Thr Arg Phe Gln Ile Ile Lys Glu Gln His Asp Ala Glu
         115                 120                 125            
 Val Glu His Leu Thr Glu Val Leu Lys Glu Lys Asn Lys Glu Thr Lys
     130                 135                 140                
 Arg Leu Arg Ser Ser Phe Asp Ala Leu Lys Glu Leu Asn Asp Thr Leu
 145                 150                 155                 160
 Lys Lys Gln Leu Asn Glu Ala Ser Glu Glu Asn Arg Lys Ile Asp Ile
                 165                 170                 175    
 Gln Ala Lys Arg Val Gln Ala Arg Leu Asp Asn Leu Gln Arg Lys Tyr
             180                 185                 190        
 Glu Phe Met Thr Ile Gln Arg Leu Lys Gly Ser Ser His Ala Val His
         195                 200                 205            
 Glu Met Lys Ser Leu Lys Gln Glu Lys Ala Pro Val Ser Lys Thr
     210                 215                 220            



      <210> 897
      <211> 94
      <212> PRT
      <213> Homo sapiens


      <400> 897
 Val Leu Phe Leu Val Pro Ile Tyr Ile His Lys Leu Val Tyr Ile Pro
   1               5                  10                  15    
 Tyr Leu Gln Lys His Ala Ser Asn His Ile Gln Lys Glu Gln Lys Val
              20                  25                  30        
 Met Gly Asn Phe Leu Phe Tyr Asn Lys Ala Leu Leu Ser Phe Trp Thr
          35                  40                  45            
 Tyr Phe Thr Ser Leu Glu Arg Leu Ser Ala His Thr Ser Thr Ile Ile
      50                  55                  60                
 Phe Phe Leu Leu Cys Gln Leu Phe Ser Ala His Val Leu His Gln Lys
  65                  70                  75                  80
 Trp His Leu Asp Asp Arg Ser Ser Lys Ser His Ile Cys Leu
                  85                  90                



      <210> 898
      <211> 60
      <212> PRT
      <213> Homo sapiens


      <400> 898
 Met Ser Phe Leu Ala Gly Leu Gly Leu Ala Val Gly Leu Ala Leu Leu
   1               5                  10                  15    
 Leu Tyr Cys Tyr Pro Pro Asp Pro Lys Gly Leu Pro Gly Thr Arg Arg
              20                  25                  30        
 Val Leu Gly Phe Ser Pro Val Ile Ile Asp Arg His Val Ser Arg Tyr
          35                  40                  45            
 Leu Leu Ala Phe Leu Ala Asp Asp Leu Gly Gly Leu
      50                  55                  60



      <210> 899
      <211> 332
      <212> PRT
      <213> Homo sapiens


      <400> 899
 Ser Trp His Gln Ser Gln Pro Cys Ser Pro Ser Leu Pro Arg Gly Ser
   1               5                  10                  15    
 Ala Tyr Ala Asn Ile Ile Ser Gln Phe Ala Gln Thr Gly Phe Leu Leu
              20                  25                  30        
 Leu Tyr Ile Gly Leu Lys Lys Leu His Leu Glu Thr Trp Ala Gly Leu
          35                  40                  45            
 Leu Ser Val Val Asp Leu Ser Ala Gln Ala Val Ile Tyr Glu Val Ala
      50                  55                  60                
 Thr Val Thr Tyr Met Ile Pro Leu Gly Leu Ser Ile Gly Val Cys Val
  65                  70                  75                  80
 Arg Val Gly Met Ala Leu Gly Ala Ala Asp Thr Val Gln Ala Lys Arg
                  85                  90                  95    
 Ser Ala Val Ser Gly Val Leu Ser Ile Val Gly Ile Ser Leu Val Leu
             100                 105                 110        
 Gly Thr Leu Ile Ser Ile Leu Lys Asn Gln Leu Gly His Ile Phe Thr
         115                 120                 125            
 Asn Asp Glu Asp Val Ile Ala Leu Val Ser Gln Val Leu Pro Val Tyr
     130                 135                 140                
 Ser Val Phe His Val Phe Glu Ala Ile Cys Cys Val Tyr Gly Gly Val
 145                 150                 155                 160
 Leu Arg Gly Thr Gly Lys Gln Ala Phe Gly Ala Ala Val Asn Ala Ile
                 165                 170                 175    
 Thr Tyr Tyr Ile Ile Gly Leu Pro Leu Gly Ile Leu Leu Thr Phe Val
             180                 185                 190        
 Val Arg Met Arg Ile Met Gly Leu Trp Leu Gly Met Leu Ala Cys Val
         195                 200                 205            
 Phe Leu Ala Thr Ala Ala Phe Val Ala Tyr Thr Ala Arg Leu Asp Trp
     210                 215                 220                
 Lys Leu Ala Ala Glu Glu Ala Lys Lys His Ser Gly Arg Gln Gln Gln
 225                 230                 235                 240
 Gln Arg Ala Glu Ser Thr Ala Thr Arg Pro Gly Pro Glu Lys Ala Val
                 245                 250                 255    
 Leu Ser Ser Val Ala Thr Gly Ser Ser Pro Gly Ile Thr Leu Thr Thr
             260                 265                 270        
 Tyr Ser Arg Ser Glu Cys His Val Asp Phe Phe Arg Thr Pro Glu Glu
         275                 280                 285            
 Ala His Ala Leu Ser Ala Pro Thr Ser Arg Leu Ser Val Lys Gln Leu
     290                 295                 300                
 Val Ile Arg Arg Gly Ala Ala Leu Gly Ala Ala Ser Ala Thr Leu Met
 305                 310                 315                 320
 Val Gly Leu Thr Val Arg Ile Leu Ala Thr Arg His
                 325                 330        



      <210> 900
      <211> 332
      <212> PRT
      <213> Homo sapiens


      <400> 900
 Ser Trp His Gln Ser Gln Pro Cys Ser Pro Ser Leu Pro Arg Gly Ser
   1               5                  10                  15    
 Ala Tyr Ala Asn Ile Ile Ser Gln Phe Ala Gln Thr Gly Phe Leu Leu
              20                  25                  30        
 Leu Tyr Ile Gly Leu Lys Lys Leu His Leu Glu Thr Trp Ala Gly Leu
          35                  40                  45            
 Leu Ser Val Val Asp Leu Ser Ala Gln Ala Val Ile Tyr Glu Val Ala
      50                  55                  60                
 Thr Val Thr Tyr Met Ile Pro Leu Gly Leu Ser Ile Gly Val Cys Val
  65                  70                  75                  80
 Arg Val Gly Met Ala Leu Gly Ala Ala Asp Thr Val Gln Ala Lys Arg
                  85                  90                  95    
 Ser Ala Val Ser Gly Val Leu Ser Ile Val Gly Ile Ser Leu Val Leu
             100                 105                 110        
 Gly Thr Leu Ile Ser Ile Leu Lys Asn Gln Leu Gly His Ile Phe Thr
         115                 120                 125            
 Asn Asp Glu Asp Val Ile Ala Leu Val Ser Gln Val Leu Pro Val Tyr
     130                 135                 140                
 Ser Val Phe His Val Phe Glu Ala Ile Cys Cys Val Tyr Gly Gly Val
 145                 150                 155                 160
 Leu Arg Gly Thr Gly Lys Gln Ala Phe Gly Ala Ala Val Asn Ala Ile
                 165                 170                 175    
 Thr Tyr Tyr Ile Ile Gly Leu Pro Leu Gly Ile Leu Leu Thr Phe Val
             180                 185                 190        
 Val Arg Met Arg Ile Met Gly Leu Trp Leu Gly Met Leu Ala Cys Val
         195                 200                 205            
 Phe Leu Ala Thr Ala Ala Phe Val Ala Tyr Thr Ala Arg Leu Asp Trp
     210                 215                 220                
 Lys Leu Ala Ala Glu Glu Ala Lys Lys His Ser Gly Arg Gln Gln Gln
 225                 230                 235                 240
 Gln Arg Ala Glu Ser Thr Ala Thr Arg Pro Gly Pro Glu Lys Ala Val
                 245                 250                 255    
 Leu Ser Ser Val Ala Thr Gly Ser Ser Pro Gly Ile Thr Leu Thr Thr
             260                 265                 270        
 Tyr Ser Arg Ser Glu Cys His Val Asp Phe Phe Arg Thr Pro Glu Glu
         275                 280                 285            
 Ala His Ala Leu Ser Ala Pro Thr Ser Arg Leu Ser Val Lys Gln Leu
     290                 295                 300                
 Val Ile Arg Arg Gly Ala Ala Leu Gly Ala Ala Ser Ala Thr Leu Met
 305                 310                 315                 320
 Val Gly Leu Thr Val Arg Ile Leu Ala Thr Arg His
                 325                 330        



      <210> 901
      <211> 70
      <212> PRT
      <213> Homo sapiens


      <400> 901
 Lys Gly Val Gly Ala Gly Arg Arg Glu Val Glu Trp Ala Ala Arg Arg
   1               5                  10                  15    
 Arg Lys Gln Ala Phe Arg Arg Leu Leu Ile Pro Arg Arg Ala Ser Leu
              20                  25                  30        
 Thr Pro Ala Arg Val Ser His Gly Ala Thr Cys Gly Glu Gln Val Pro
          35                  40                  45            
 Pro Gly Thr Glu Asp Arg Glu Arg Val Leu Arg Arg Tyr Leu Pro Gly
      50                  55                  60                
 Cys Gln His Arg Leu Trp
  65                  70



      <210> 902
      <211> 770
      <212> PRT
      <213> Homo sapiens


      <400> 902
 Ser Ile Arg Cys Leu Asp Leu Ser Met Ser Thr Val Glu Glu Asp Ser
   1               5                  10                  15    
 Asp Thr Val Thr Val Glu Thr Val Asn Ser Val Thr Leu Thr Gln Asp
              20                  25                  30        
 Thr Glu Gly Asn Leu Ile Leu His Cys Pro Gln Asn Glu Ala Asp Glu
          35                  40                  45            
 Ile Asp Ser Glu Asp Ser Ile Glu Pro Pro His Lys Arg Leu Cys Leu
      50                  55                  60                
 Ser Ser Glu Asp Asp Gln Ser Ile Asp Asp Ser Thr Pro Cys Ile Ser
  65                  70                  75                  80
 Val Val Ala Leu Pro Leu Ser Glu Asn Asp Gln Ser Phe Glu Val Thr
                  85                  90                  95    
 Met Thr Ala Thr Thr Glu Val Ala Asp Asp Glu Val Thr Glu Gly Thr
             100                 105                 110        
 Val Thr Gln Ile Gln Ile Leu Gln Asn Glu Gln Leu Asp Glu Ile Ser
         115                 120                 125            
 Pro Leu Gly Asn Glu Glu Val Ser Ala Val Ser Gln Ala Trp Phe Thr
     130                 135                 140                
 Thr Lys Glu Asp Lys Asp Ser Leu Thr Asn Lys Gly His Lys Trp Lys
 145                 150                 155                 160
 Gln Gly Met Trp Ser Lys Glu Glu Ile Asp Ile Leu Met Asn Asn Ile
                 165                 170                 175    
 Glu Arg Tyr Leu Lys Ala Arg Gly Ile Lys Asp Ala Thr Glu Ile Ile
             180                 185                 190        
 Phe Glu Met Ser Lys Asp Glu Arg Lys Asp Phe Tyr Arg Thr Ile Ala
         195                 200                 205            
 Trp Gly Leu Asn Arg Pro Leu Phe Ala Val Tyr Arg Arg Val Leu Arg
     210                 215                 220                
 Met Tyr Asp Asp Arg Asn His Val Gly Lys Tyr Thr Pro Glu Glu Ile
 225                 230                 235                 240
 Glu Lys Leu Lys Glu Leu Arg Ile Lys His Gly Asn Asp Trp Ala Thr
                 245                 250                 255    
 Ile Gly Ala Ala Leu Gly Arg Ser Ala Ser Ser Val Lys Asp Arg Cys
             260                 265                 270        
 Arg Leu Met Lys Asp Thr Cys Asn Thr Gly Lys Trp Thr Glu Glu Glu
         275                 280                 285            
 Glu Lys Arg Leu Ala Glu Val Val His Glu Leu Thr Ser Thr Glu Pro
     290                 295                 300                
 Gly Asp Ile Val Thr Gln Gly Val Ser Trp Ala Ala Val Ala Glu Arg
 305                 310                 315                 320
 Val Gly Thr Arg Ser Glu Lys Gln Cys Arg Ser Lys Trp Leu Asn Tyr
                 325                 330                 335    
 Leu Asn Trp Lys Gln Ser Gly Gly Thr Glu Trp Thr Lys Glu Asp Glu
             340                 345                 350        
 Ile Asn Leu Ile Leu Arg Ile Ala Glu Leu Asp Val Ala Asp Glu Asn
         355                 360                 365            
 Asp Ile Asn Trp Asp Leu Leu Ala Glu Gly Trp Ser Ser Val Arg Ser
     370                 375                 380                
 Pro Gln Trp Leu Arg Ser Lys Trp Trp Thr Ile Lys Arg Gln Ile Ala
 385                 390                 395                 400
 Asn His Lys Asp Val Ser Phe Pro Val Leu Ile Lys Gly Leu Lys Gln
                 405                 410                 415    
 Leu His Glu Asn Gln Lys Asn Asn Pro Thr Leu Leu Glu Asn Lys Ser
             420                 425                 430        
 Gly Ser Gly Val Pro Asn Ser Asn Thr Asn Ser Ser Val Gln His Val
         435                 440                 445            
 Gln Ile Arg Val Ala Arg Leu Glu Asp Asn Thr Ala Ile Ser Ser Ser
     450                 455                 460                
 Pro Met Ala Ala Leu Gln Ile Pro Val Gln Ile Thr His Val Ser Ser
 465                 470                 475                 480
 Ala Asp Ser Pro Ala Thr Val Asp Ser Glu Thr Ile Thr Leu Asn Ser
                 485                 490                 495    
 Gly Thr Leu Gln Thr Phe Glu Ile Leu Pro Ser Phe His Leu Gln Pro
             500                 505                 510        
 Thr Gly Thr Pro Gly Thr Tyr Leu Leu Gln Thr Ser Ser Ser Gln Gly
         515                 520                 525            
 Leu Pro Leu Thr Leu Thr Ala Ser Pro Thr Val Thr Leu Thr Ala Ala
     530                 535                 540                
 Ala Pro Ala Ser Pro Glu Gln Ile Ile Val His Ala Leu Ser Pro Glu
 545                 550                 555                 560
 His Leu Leu Asn Thr Ser Asp Asn Val Thr Val Gln Cys His Thr Pro
                 565                 570                 575    
 Arg Val Ile Ile Gln Thr Val Ala Thr Glu Asp Ile Thr Ser Ser Ile
             580                 585                 590        
 Ser Gln Ala Gln Glu Leu Thr Val Asp Ser Asp Ile Gln Phe Ile Leu
         595                 600                 605            
 Asp Phe Pro Glu Pro Pro Asp Ala Leu Glu Ala Asn Thr Phe Pro Asp
     610                 615                 620                
 Glu Ile His His Pro Lys Met Thr Val Glu Pro Ser Phe Asn Asp Ala
 625                 630                 635                 640
 His Val Ser Lys Phe Ser Asp Gln Asn Ser Thr Glu Leu Met Asn Ser
                 645                 650                 655    
 Val Met Val Arg Thr Glu Lys Glu Ile Ser Asp Thr Asp Leu Lys Gln
             660                 665                 670        
 Glu Glu Ser Pro Ser Asp Leu Ala Ser Ala Tyr Val Thr Glu Gly Leu
         675                 680                 685            
 Glu Ser Pro Thr Ile Glu Glu Gln Val Asp Gln Thr Ile Asp Asp Glu
     690                 695                 700                
 Thr Ile Leu Ile Val Pro Ser Pro His Gly Phe Ile Gln Ala Ser Asp
 705                 710                 715                 720
 Val Ile Asp Thr Glu Ser Val Leu Pro Leu Thr Thr Leu Thr Asp Pro
                 725                 730                 735    
 Ile Leu Gln His His Gln Glu Glu Ser Asn Ile Ile Gly Ser Ser Leu
             740                 745                 750        
 Gly Ser Pro Val Ser Glu Asp Ser Lys Asp Val Glu Asp Leu Val Asn
         755                 760                 765            
 Cys His
     770



      <210> 903
      <211> 178
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(178)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 903
 Thr Leu Tyr Thr Tyr Phe Thr Phe Arg Arg Ser Arg His Leu Leu Leu
   1               5                  10                  15    
 Pro Pro Pro Arg Pro Thr His Arg Arg Pro Pro Pro Gly Thr Lys Leu
              20                  25                  30        
 Asp Xaa Arg Pro Leu Gly Val Cys Gly Gly Thr Xaa Asn Pro Pro Leu
          35                  40                  45            
 Met Lys Ser His Leu Leu Arg Pro Leu Pro Pro Gly Arg Pro Met Ala
      50                  55                  60                
 Glu Pro Pro Cys Ser Pro Gly Ile Gly Leu Ala Leu Arg Gly Gly Gln
  65                  70                  75                  80
 Arg Pro Tyr Tyr Pro His Ser Pro Val Arg Pro Phe Val Pro Leu Gly
                  85                  90                  95    
 Leu Arg Pro Val Ala Gly Pro Arg Arg Cys Phe Ser Pro Pro Pro Pro
             100                 105                 110        
 Ser Ser Ala Gln Pro Ser Pro Ala His Ser Ala Leu Arg Gly Pro Ser
         115                 120                 125            
 Pro Gln Arg Arg Thr Pro Glu Val Ser Pro Ser Cys Gly Xaa Gly Ala
     130                 135                 140                
 Trp Asp Pro Arg Pro Glu Gln Gly Glu His Pro Tyr Ile Leu Ala Gln
 145                 150                 155                 160
 Lys Asp Leu Cys Gly Ser Leu Ala Gly Leu Val Leu Ser His Arg Val
                 165                 170                 175    
 Gln Ile
        



      <210> 904
      <211> 205
      <212> PRT
      <213> Homo sapiens


      <400> 904
 Leu Leu Arg Leu Asn Asp Ile Ser Ala Gly Asp Arg Ile Pro Ala Trp
   1               5                  10                  15    
 Thr Phe Asp Met Asn Thr Gly Ala Trp Val Asn His Gly Arg Gly Met
              20                  25                  30        
 Val Lys Glu His Asn Asn His Leu Ile Trp Thr Tyr Asp Ala Pro His
          35                  40                  45            
 Leu Gly Tyr Trp Ile Ala Ala Pro Leu Pro Gly Thr Arg Gly Ser Gly
      50                  55                  60                
 Ile Asn Glu Asp Ser Lys Asp Ile Thr Ala Tyr His Thr Val Phe Leu
  65                  70                  75                  80
 Thr Ala Ile Leu Gly Gly Thr Ile Val Ile Val Ile Gly Phe Phe Ala
                  85                  90                  95    
 Val Leu Leu Cys Tyr Cys Arg Asp Lys Cys Gly Thr Pro Gln Lys Arg
             100                 105                 110        
 Glu Arg Asn Ile Thr Lys Leu Glu Val Leu Lys Arg Asp Gln Thr Thr
         115                 120                 125            
 Ser Thr Thr His Ile Asn His Ile Ser Thr Val Lys Val Ala Leu Lys
     130                 135                 140                
 Ala Glu Asp Lys Ser Gln Leu Phe Asn Ala Lys Asn Ser Ser Tyr Ser
 145                 150                 155                 160
 Pro Gln Lys Lys Glu Pro Ser Lys Ala Glu Thr Glu Glu Arg Val Ser
                 165                 170                 175    
 Met Val Lys Thr Arg Asp Asp Phe Lys Ile Tyr Asn Glu Asp Val Ser
             180                 185                 190        
 Phe Leu Ser Val Asn Gln Asn Asn Tyr Ser Arg Asn Pro
         195                 200                 205



      <210> 905
      <211> 208
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(208)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 905
 Gly Gly Ser Gly Ala Leu Ala Val Gln Leu Gly Ala Leu Leu Leu Gln
   1               5                  10                  15    
 Gly Cys Pro Gly Gly Gln His Leu Asp Val Val Thr Gly Gly Leu Thr
              20                  25                  30        
 Leu Arg Pro Leu Val Leu Gln Pro Val Phe Pro Val Leu Glu Gly Arg
          35                  40                  45            
 Gly Glu Leu Phe Gly Ser Asp Pro Gly Arg Ser Ala Pro Pro Pro Gly
      50                  55                  60                
 Leu Ser Lys Leu Leu Xaa Gly Leu Pro Arg Pro Leu Pro Glu Ser Gly
  65                  70                  75                  80
 Arg Ser Trp Lys Pro Arg Ser Gln Pro Ser Ala Trp Arg Trp Trp Arg
                  85                  90                  95    
 Pro Ala Gln Arg Pro Gln Arg Arg Gly Pro Pro Ser Arg Gly Ser Cys
             100                 105                 110        
 Trp Pro Ala Gly Gly Xaa Gly Ser Cys Ala Cys Arg Arg Arg Gly Cys
         115                 120                 125            
 Ser Ala Cys Thr Cys Pro Pro Pro Trp Cys Arg Pro Gly Arg Ser Cys
     130                 135                 140                
 Ser Arg Ser His Gly Ala Gly Cys Trp Pro Thr Arg Pro Arg Thr Xaa
 145                 150                 155                 160
 Ala Arg Pro Ser Ala Gly Ser Arg Arg Ser Arg Ser Val Cys Arg Ser
                 165                 170                 175    
 Ser Thr Arg Pro Arg Arg Ser Arg Trp Trp Trp Arg Arg Cys Arg Pro
             180                 185                 190        
 Arg Xaa Pro Pro Ala Arg Pro Gln Pro Arg Pro Gly Xaa Trp Trp Ser
         195                 200                 205            





      <210> 906
      <211> 181
      <212> PRT
      <213> Homo sapiens


      <400> 906
 Asp Gln Arg Ala Ala Gly Phe Glu Ser Ile Phe Pro Gly Val Thr Ile
   1               5                  10                  15    
 Asn Lys Asn Val Ala Trp Ile Asn Tyr Ile Tyr Tyr Asn Gln Gln Trp
              20                  25                  30        
 Phe Ile Asn Tyr Thr Arg Asp Ala Ile Lys Gly Ile Ala Asp Gln Leu
          35                  40                  45            
 Gly Pro Thr Ser Gln Met Ala Trp Glu Asn Arg Met Ala Leu Asp Met
      50                  55                  60                
 Ile Leu Ala Lys Lys Gly Gly Val Cys Val Met Ile Lys Thr Gln Cys
  65                  70                  75                  80
 Cys Thr Phe Ile Pro Asn Asn Thr Ala Pro Ser Gly Ser Ile Thr Arg
                  85                  90                  95    
 Ala Leu Gln Gly Leu Thr Ala Leu Ser Asn Glu Leu Ala Lys Asn Ser
             100                 105                 110        
 Gly Val Asn Asp Pro Phe Ser Gly Trp Leu Glu Arg Trp Phe Gly Lys
         115                 120                 125            
 Trp Lys Gly Ile Ile Ala Ser Ile Leu Thr Ser Leu Ala Ala Val Ile
     130                 135                 140                
 Gly Val Ala Ile Leu Phe Gly Cys Cys Val Thr Pro Cys Ile Arg Gly
 145                 150                 155                 160
 Leu Val Gln Arg Leu Ile Glu Thr Val Leu Thr Lys Thr Ser Leu Ser
                 165                 170                 175    
 Ser Pro Pro Pro Tyr
             180    



      <210> 907
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 907
 Pro Leu Leu Thr Asp Leu Tyr Gln Ala Thr Met Ala Leu Gly Tyr Trp
   1               5                  10                  15    
 Arg Ala Gly Arg Ala Arg Asp Ala Ala Glu Phe Glu Leu Phe Phe Arg
              20                  25                  30        
 Arg Cys Pro Phe Gly Gly Ala Phe Ala Leu Ala Ala Gly Leu Arg Asp
          35                  40                  45            
 Cys Val Arg Phe Leu Arg Ala Phe Arg Leu Arg Asp Ala Asp Val Gln
      50                  55                  60                
 Phe Leu Ala Ser Val Leu Pro Pro Asp Thr Asp Pro Ala Phe Phe Glu
  65                  70                  75                  80
 His Leu Arg Ala Leu Asp Cys Ser Glu Val Thr Val Arg Ala Leu Pro
                  85                  90                  95    
 Glu Gly Ser Leu Ala Phe Pro Gly Val Pro Leu Leu Gln Val Ser Gly
             100                 105                 110        
 Pro Leu Leu Val Val Gln Leu Leu Glu Thr Pro Leu Leu Cys Leu Val
         115                 120                 125            
 Ser Tyr Ala Ser Leu Val Ala Thr Asn Ala Ala Arg Leu Arg Leu Ile
     130                 135                 140                
 Ala Gly Pro Glu Lys Arg Leu Leu Glu Met Gly Leu Arg Arg Ala Gln
 145                 150                 155                 160
 Gly Pro Asp Gly Gly Leu Thr Ala Ser Thr Tyr Ser Tyr Leu Gly Gly
                 165                 170                 175    
 Phe Asp Ser Ser Ser Asn Val Leu Ala Gly Gln Leu Arg Gly Val Pro
             180                 185                 190        
 Ala Ala Gly Thr Leu Ala His Ser Phe Val Thr Ser Phe Ser Gly Ser
         195                 200                 205            
 Glu Val Pro Pro Asp Pro Met Leu Ala Pro Ala Ala Gly Glu Gly Pro
     210                 215                 220                
 Gly Val Asp Leu Ala Ala Lys Ala Gln Val Trp Leu Glu Gln Val Cys
 225                 230                 235                 240
 Ala His Leu Gly Leu Gly Val Gln Glu Pro His Pro Gly Glu Arg Ala
                 245                 250                 255    
 Ala Phe Val Ala Tyr Ala Leu Ala Phe Pro Arg Ala Phe Gln Gly Leu
             260                 265                 270        
 Leu Asp Thr Tyr Ser Val Trp Arg Ser Gly Leu Pro Asn Phe Leu Ala
         275                 280                 285            
 Val Ala Leu Ala Leu Gly Glu Leu Gly
     290                 295        



      <210> 908
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 908
 Pro Leu Leu Thr Asp Leu Tyr Gln Ala Thr Met Ala Leu Gly Tyr Trp
   1               5                  10                  15    
 Arg Ala Gly Arg Ala Arg Asp Ala Ala Glu Phe Glu Leu Phe Phe Arg
              20                  25                  30        
 Arg Cys Pro Phe Gly Gly Ala Phe Ala Leu Ala Ala Gly Leu Arg Asp
          35                  40                  45            
 Cys Val Arg Phe Leu Arg Ala Phe Arg Leu Arg Asp Ala Asp Val Gln
      50                  55                  60                
 Phe Leu Ala Ser Val Leu Pro Pro Asp Thr Asp Pro Ala Phe Phe Glu
  65                  70                  75                  80
 His Leu Arg Ala Leu Asp Cys Ser Glu Val Thr Val Arg Ala Leu Pro
                  85                  90                  95    
 Glu Gly Ser Leu Ala Phe Pro Gly Val Pro Leu Leu Gln Val Ser Gly
             100                 105                 110        
 Pro Leu Leu Val Val Gln Leu Leu Glu Thr Pro Leu Leu Cys Leu Val
         115                 120                 125            
 Ser Tyr Ala Ser Leu Val Ala Thr Asn Ala Ala Arg Leu Arg Leu Ile
     130                 135                 140                
 Ala Gly Pro Glu Lys Arg Leu Leu Glu Met Gly Leu Arg Arg Ala Gln
 145                 150                 155                 160
 Gly Pro Asp Gly Gly Leu Thr Ala Ser Thr Tyr Ser Tyr Leu Gly Gly
                 165                 170                 175    
 Phe Asp Ser Ser Ser Asn Val Leu Ala Gly Gln Leu Arg Gly Val Pro
             180                 185                 190        
 Ala Ala Gly Thr Leu Ala His Ser Phe Val Thr Ser Phe Ser Gly Ser
         195                 200                 205            
 Glu Val Pro Pro Asp Pro Met Leu Ala Pro Ala Ala Gly Glu Gly Pro
     210                 215                 220                
 Gly Val Asp Leu Ala Ala Lys Ala Gln Val Trp Leu Glu Gln Val Cys
 225                 230                 235                 240
 Ala His Leu Gly Leu Gly Val Gln Glu Pro His Pro Gly Glu Arg Ala
                 245                 250                 255    
 Ala Phe Val Ala Tyr Ala Leu Ala Phe Pro Arg Ala Phe Gln Gly Leu
             260                 265                 270        
 Leu Asp Thr Tyr Ser Val Trp Arg Ser Gly Leu Pro Asn Phe Leu Ala
         275                 280                 285            
 Val Ala Leu Ala Leu Gly Glu Leu Gly
     290                 295        



      <210> 909
      <211> 297
      <212> PRT
      <213> Homo sapiens


      <400> 909
 Pro Leu Leu Thr Asp Leu Tyr Gln Ala Thr Met Ala Leu Gly Tyr Trp
   1               5                  10                  15    
 Arg Ala Gly Arg Ala Arg Asp Ala Ala Glu Phe Glu Leu Phe Phe Arg
              20                  25                  30        
 Arg Cys Pro Phe Gly Gly Ala Phe Ala Leu Ala Ala Gly Leu Arg Asp
          35                  40                  45            
 Cys Val Arg Phe Leu Arg Ala Phe Arg Leu Arg Asp Ala Asp Val Gln
      50                  55                  60                
 Phe Leu Ala Ser Val Leu Pro Pro Asp Thr Asp Pro Ala Phe Phe Glu
  65                  70                  75                  80
 His Leu Arg Ala Leu Asp Cys Ser Glu Val Thr Val Arg Ala Leu Pro
                  85                  90                  95    
 Glu Gly Ser Leu Ala Phe Pro Gly Val Pro Leu Leu Gln Val Ser Gly
             100                 105                 110        
 Pro Leu Leu Val Val Gln Leu Leu Glu Thr Pro Leu Leu Cys Leu Val
         115                 120                 125            
 Ser Tyr Ala Ser Leu Val Ala Thr Asn Ala Ala Arg Leu Arg Leu Ile
     130                 135                 140                
 Ala Gly Pro Glu Lys Arg Leu Leu Glu Met Gly Leu Arg Arg Ala Gln
 145                 150                 155                 160
 Gly Pro Asp Gly Gly Leu Thr Ala Ser Thr Tyr Ser Tyr Leu Gly Gly
                 165                 170                 175    
 Phe Asp Ser Ser Ser Asn Val Leu Ala Gly Gln Leu Arg Gly Val Pro
             180                 185                 190        
 Ala Ala Gly Thr Leu Ala His Ser Phe Val Thr Ser Phe Ser Gly Ser
         195                 200                 205            
 Glu Val Pro Pro Asp Pro Met Leu Ala Pro Ala Ala Gly Glu Gly Pro
     210                 215                 220                
 Gly Val Asp Leu Ala Ala Lys Ala Gln Val Trp Leu Glu Gln Val Cys
 225                 230                 235                 240
 Ala His Leu Gly Leu Gly Val Gln Glu Pro His Pro Gly Glu Arg Ala
                 245                 250                 255    
 Ala Phe Val Ala Tyr Ala Leu Ala Phe Pro Arg Ala Phe Gln Gly Leu
             260                 265                 270        
 Leu Asp Thr Tyr Ser Val Trp Arg Ser Gly Leu Pro Asn Phe Leu Ala
         275                 280                 285            
 Val Ala Leu Ala Leu Gly Glu Leu Gly
     290                 295        



      <210> 910
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 910
 Gln Leu Ala Ile Glu Ile Gly Val Arg Ala Leu Leu Phe Gly Val Phe
   1               5                  10                  15    
 Val Phe Thr Glu Phe Leu Asp Pro Phe Gln Arg Val Ile Gln Pro Glu
              20                  25                  30        
 Glu Ile Trp Leu Tyr Lys Asn Pro Leu Gly Gln Ser Asp Asn Ile Pro
          35                  40                  45            
 Thr Arg Leu Met Phe Ala Ile Ser Phe Leu Thr Pro Leu Ala Val Ile
      50                  55                  60                
 Cys Val Val Lys Ile Ile Arg Arg Thr Asp Lys Thr Glu Ile Lys Glu
  65                  70                  75                  80
 Ala Phe Leu Ala Val Ser Leu Ala Leu Ala Leu Asn Gly Val Cys Thr
                  85                  90                  95    
 Asn Thr Ile Lys Leu Ile Val Gly Arg Pro Arg Pro Asp Phe Phe Tyr
             100                 105                 110        
 Arg Cys Phe Pro Asp Gly Val Met Asn Ser Glu Met His Cys Thr Gly
         115                 120                 125            
 Asp Pro Asp Leu Val Ser Glu Gly Arg Lys Ser Phe Pro Ser Ile His
     130                 135                 140                
 Ser Ser Phe Ala Phe Ser Gly Leu Gly Phe Thr Thr Phe Tyr Leu Ala
 145                 150                 155                 160
 Gly Lys Leu His Cys Phe Thr Glu Ser Gly Arg Gly Lys Ser Trp Arg
                 165                 170                 175    
 Leu Cys Ala Ala Ile Leu Pro Leu
             180                



      <210> 911
      <211> 141
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(141)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 911
 Leu Ser Val Pro Arg Leu Val Leu Pro Ser Pro Pro Pro Pro Ala Asn
   1               5                  10                  15    
 Thr Gly Pro Ala Val Ser Leu Cys Val Val Ser Pro Cys Ser Pro Arg
              20                  25                  30        
 Ala Ala Val Phe Thr Arg Lys Ser Pro Ala Met Ala Glu His Gly Leu
          35                  40                  45            
 Cys Ala Pro Ala Pro Pro His Pro Asp Met Asp Arg Glu Glu Pro Gly
      50                  55                  60                
 Asn Pro His Pro Pro Ser Ser Xaa Thr Ser Gln Leu Cys Pro Pro Ala
  65                  70                  75                  80
 Thr Pro Pro Pro Gly Phe Pro Pro Gln Gly Lys Thr Leu Xaa Pro Gly
                  85                  90                  95    
 Pro Glu Thr Gly Gly Leu Pro Asn Thr Ser Leu Pro Phe Pro Thr Ser
             100                 105                 110        
 Ser Ala Pro Ala Pro Val Ala Pro Leu Leu Pro Val Arg Leu Ser Val
         115                 120                 125            
 Ala Ser Leu Arg Thr Glu Ala Gly Cys Ser Val Pro Ala
     130                 135                 140    



      <210> 912
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 912
 Phe Arg Leu Leu Gly Val Val Ala Phe Ser Thr Leu Met Leu Lys Arg
   1               5                  10                  15    
 Phe Arg Glu Pro Lys His Glu Arg Arg Pro Trp Arg Ile Trp Phe Leu
              20                  25                  30        
 Asp Thr Ser Lys Gln Ala Ile Gly Met Leu Phe Ile His Phe Ala Asn
          35                  40                  45            
 Val Tyr Leu Ala Asp Leu Thr Glu Glu Asp Pro Cys Ser Leu Tyr Leu
      50                  55                  60                
 Ile Asn Phe Leu Leu Asp Ala Thr Val Gly Met Leu Leu Ile Tyr Val
  65                  70                  75                  80
 Gly Val Arg Ala Val Ser Val Leu Val Glu Trp Gln Gln Trp Glu Ser
                  85                  90                  95    
 Leu Arg Phe Gly Glu Tyr Gly Asp Pro Leu Gln Cys Gly Ala Trp Val
             100                 105                 110        
 Gly Gln Cys Ala Leu Tyr Ile Val Ile Met Ile Phe Glu Lys Ser Val
         115                 120                 125            
 Val Phe Ile Val Leu Leu Ile Leu Gln Trp Lys Lys Val Ala Leu Leu
     130                 135                 140                
 Asn Pro Ile Glu Asn Pro Asp Leu Lys Leu Ala Ile Val Met Leu Ile
 145                 150                 155                 160
 Val Pro Phe Phe Val Asn Ala Leu Met Phe Trp Val Val Asp Asn Phe
                 165                 170                 175    
 Leu Met Arg Lys Gly Lys Thr Lys Ala Lys Leu Glu Glu Arg Gly Ala
             180                 185                 190        
 Asn Gln Asp Ser Arg Asn Gly Ser Lys Val Arg Tyr Arg Arg Ala Ala
         195                 200                 205            
 Ser His Glu Glu Ser Glu Ser Glu Ile Leu Ile Ser Ala Asp Asp Glu
     210                 215                 220                
 Met Glu Glu Ser Asp Val Glu Glu Asp Leu Arg Arg Leu Thr Pro Leu
 225                 230                 235                 240
 Lys Pro Val Lys Lys Lys Lys His Arg Phe Gly Leu Pro Val
                 245                 250                



      <210> 913
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 913
 Gly Trp Asn Ser Gly Ser Leu Arg Leu Gly Thr Glu Ala Ala Ala Arg
   1               5                  10                  15    
 Arg Thr Ala Gly Ala Met Tyr Leu Arg Arg Ala Val Ser Lys Thr Leu
              20                  25                  30        
 Ala Leu Pro Leu Arg Ala Pro Pro Asn Pro Ala Pro Leu Gly Lys Asp
          35                  40                  45            
 Ala Ser Leu Arg Arg Met Ser Ser Asn Arg Phe Pro Gly Ser Ser Gly
      50                  55                  60                
 Ser Asn Met Ile Tyr Tyr Leu Val Val Gly Val Thr Val Ser Ala Gly
  65                  70                  75                  80
 Gly Tyr Tyr Ala Tyr Lys Thr Val Thr Ser Asp Gln Ala Lys His Thr
                  85                  90                  95    
 Glu His Lys Thr Asn Leu Lys Glu Lys Thr Lys Ala Glu Ile His Pro
             100                 105                 110        
 Phe Gln Gly Glu Lys Glu Asn Val Ala Glu Thr Glu Lys Ala Ser Ser
         115                 120                 125            
 Glu Ala Pro Glu Glu Leu Ile Val Glu Ala Glu Val Val Asp Ala Glu
     130                 135                 140                
 Glu Ser Pro Ser Ala Thr Val Val Val Ile Lys Glu Ala Ser Ala Cys
 145                 150                 155                 160
 Pro Gly His Val Glu Ala Ala Pro Glu Thr Thr Ala Val Ser Ala Glu
                 165                 170                 175    
 Thr Gly Pro Glu Val Thr Asp Ala Ala Ala Arg Glu Thr Thr Glu Val
             180                 185                 190        
 Asn Pro Glu Thr Thr Pro Glu Val Thr Asn Ala Ala Leu Asp Glu Ala
         195                 200                 205            
 Val Thr Ile Asp Asn Asp Lys Asp Thr Thr Lys Asn Glu Thr Ser Asp
     210                 215                 220                
 Glu Tyr Ala Glu Leu Glu Glu Glu Asn Ser Pro Ala Glu Ser Glu Ser
 225                 230                 235                 240
 Ser Ala Gly Asp Asp Leu Gln Glu Glu Ala Ser Val Gly Ser Glu Ala
                 245                 250                 255    
 Ala Ser Ala Gln Gly
             260    



      <210> 914
      <211> 318
      <212> PRT
      <213> Homo sapiens


      <400> 914
 Pro Arg Leu Phe Pro Val Leu Trp Thr Ile Met Gly Asn Thr Leu Gly
   1               5                  10                  15    
 Leu Ala Pro Met Gly Thr Leu Pro Arg Arg Ser Pro Arg Arg Glu Glu
              20                  25                  30        
 Pro Leu Pro Asn Pro Gly Ser Phe Asp Glu Leu His Arg Leu Cys Lys
          35                  40                  45            
 Asp Val Phe Pro Ala Gln Met Glu Gly Val Lys Leu Val Val Asn Lys
      50                  55                  60                
 Val Leu Ser Ser His Phe Gln Val Ala His Thr Ile His Met Ser Ala
  65                  70                  75                  80
 Leu Gly Leu Pro Gly Tyr His Leu His Ala Ala Tyr Ala Gly Asp Trp
                  85                  90                  95    
 Gln Leu Ser Pro Thr Glu Val Phe Pro Thr Val Val Gly Asp Met Asp
             100                 105                 110        
 Ser Ser Gly Ser Leu Asn Ala Gln Val Leu Leu Leu Leu Ala Glu Arg
         115                 120                 125            
 Leu Arg Ala Lys Ala Val Phe Gln Thr Gln Gln Ala Lys Phe Leu Thr
     130                 135                 140                
 Trp Gln Phe Asp Gly Glu Tyr Arg Gly Asp Asp Tyr Thr Ala Thr Leu
 145                 150                 155                 160
 Thr Leu Gly Asn Pro Asp Leu Ile Gly Glu Ser Val Ile Met Val Ala
                 165                 170                 175    
 His Phe Leu Gln Ser Leu Thr His Arg Leu Val Leu Gly Gly Glu Leu
             180                 185                 190        
 Val Tyr His Arg Arg Pro Gly Glu Glu Gly Ala Ile Leu Thr Leu Ala
         195                 200                 205            
 Gly Lys Tyr Ser Ala Val His Trp Val Ala Thr Leu Asn Val Gly Ser
     210                 215                 220                
 Gly Gly Ala His Ala Ser Tyr Tyr His Arg Ala Asn Glu Gln Val Gln
 225                 230                 235                 240
 Val Gly Val Glu Phe Glu Ala Asn Thr Arg Leu Gln Asp Thr Thr Phe
                 245                 250                 255    
 Ser Phe Gly Tyr His Leu Thr Leu Pro Gln Ala Asn Met Val Phe Arg
             260                 265                 270        
 Gly Leu Val Asp Ser Asn Trp Cys Val Gly Ala Val Leu Glu Lys Lys
         275                 280                 285            
 Met Pro Pro Leu Pro Val Thr Leu Ala Leu Gly Ala Phe Leu Asn His
     290                 295                 300                
 Trp Arg Asn Arg Phe His Cys Gly Phe Ser Ile Thr Val Gly
 305                 310                 315            



      <210> 915
      <211> 131
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(131)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 915
 Pro Glu Gly Ser Glu Val Leu Lys Val Val Ala Met Asp Gly Asp Arg
   1               5                  10                  15    
 Gly Lys Pro Asn Arg Ile Leu Tyr Ser Leu Val Asn Gly Asn Asp Gly
              20                  25                  30        
 Ala Phe Glu Ile Asn Glu Thr Ser Gly Ala Ile Ser Ile Thr Gln Ser
          35                  40                  45            
 Pro Ala Gln Leu Gln Arg Glu Val Tyr Glu Leu His Val Gln Val Thr
      50                  55                  60                
 Glu Met Ser Pro Ala Gly Ser Pro Ala Ala Gln Ala Thr Val Pro Val
  65                  70                  75                  80
 Thr Ile Arg Ile Val Asp Leu Asn Asn His Pro Pro Thr Phe Tyr Gly
                  85                  90                  95    
 Glu Ser Gly Pro Gln Asn Arg Phe Glu Leu Ser Met Asn Glu His Pro
             100                 105                 110        
 Pro Gln Gly Glu Ile Leu Arg Xaa Leu Lys Ile Thr Val Asn Asp Ser
         115                 120                 125            
 Asp Gln Gly
     130    



      <210> 916
      <211> 298
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(298)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 916
 Leu Cys Val Pro Arg Pro Pro Ala Met Ala Leu Ser Leu Pro Leu Gly
   1               5                  10                  15    
 Pro Arg Leu Gly Ser Glu Pro Leu Asn His Pro Pro Gly Ala Pro Arg
              20                  25                  30        
 Glu Ala Asp Ile Val Gly Cys Thr Val Cys Pro Ala Ser Gly Glu Glu
          35                  40                  45            
 Ser Thr Ser Pro Glu Gln Ala Gln Thr Leu Gly Gln Asp Ser Leu Gly
      50                  55                  60                
 Pro Pro Glu His Phe Gln Gly Gly Pro Arg Gly Asn Glu Pro Ala Ala
  65                  70                  75                  80
 His Pro Pro Arg Trp Ser Thr Pro Ser Ser Tyr Gly Gly Pro Ser Trp
                  85                  90                  95    
 Gly Gln Thr Leu Xaa Ala Pro His Phe Trp Pro Gly Gly Thr Arg Gly
             100                 105                 110        
 Xaa Ala Glu Gln Pro Ala Pro Val Pro Ala Gly Ala Gly Pro Pro Ala
         115                 120                 125            
 Ala Gly Pro Gly Ala Arg Pro Gly Ala Leu Gly Ile Gly Pro Glu Trp
     130                 135                 140                
 Asp Gly Ala Ala Ala Gly Pro Pro Gly Gly Pro Thr Arg Gly Ser Xaa
 145                 150                 155                 160
 Ala Cys Gly Gly Ala Ala Ser Val Trp Xaa Gly Ala Gly Thr Ala Glu
                 165                 170                 175    
 Xaa Ala Gln Gly Leu Gly Ser Pro Gly Ala Asp Pro Ala Gly Pro Gly
             180                 185                 190        
 Ser Leu Pro Arg Leu His Leu Pro Ala Ala Leu Ala Ala Ala Gly Pro
         195                 200                 205            
 Ala Gly Gln Leu Gln Pro Gly Val Arg Gly Gly Gln His Ala Gly Pro
     210                 215                 220                
 Gly Leu Gly Gly Arg Gly Arg Leu Gly Leu Ala Arg Thr Ser Val Gly
 225                 230                 235                 240
 Ser Gly Gly Pro Gly His Pro Val Ala Ser Pro Leu Pro Gln Ser Trp
                 245                 250                 255    
 Ser Gly Ile Arg Arg Gly Thr Leu Gly Ala Leu Gly Pro Trp Asp Lys
             260                 265                 270        
 Arg Gln Pro Gly His Xaa Glu Cys Pro Val Ser Cys Val Ala Thr Gly
         275                 280                 285            
 Gly Pro Arg Ala Gly Asp Lys Ala Leu Arg
     290                 295            



      <210> 917
      <211> 1370
      <212> PRT
      <213> Homo sapiens


      <400> 917
 Ser Trp Gly Ala Gly Ala Thr Thr Phe Gln Glu Tyr Gln Lys Thr Gly
   1               5                  10                  15    
 Glu Leu Ser Thr Ser Asp His Ile Phe Pro Leu Thr Pro Gly Leu Val
              20                  25                  30        
 Tyr Ser Ile Pro Phe Asp His Ile Val Leu His Ser Gly Gln Arg Pro
          35                  40                  45            
 Pro Glu Leu Pro Lys Ser Thr Glu Ile His Glu Gln Lys Arg His Cys
      50                  55                  60                
 Asn Thr Thr Arg His Ser Lys Pro Thr Asp Lys Pro Thr Gly Asn Ser
  65                  70                  75                  80
 Lys Thr Ile Asp His Lys Ser Ser Thr Asp Asn His Glu Ala Pro Pro
                  85                  90                  95    
 Thr Ser Glu Glu Asn Ser Ser Asn Gln Gly Lys Asp Pro Met Ile Arg
             100                 105                 110        
 Asn Gln Arg Ser Val Asp Pro Ala Asp Ser Thr Thr Thr His Lys Glu
         115                 120                 125            
 Ser Ala Gly Lys Lys His Ile Thr Pro Ala Pro Lys Ser Lys Ile Asn
     130                 135                 140                
 Cys Arg Lys Ser Thr Thr Gly Lys Ser Thr Val Thr Arg Lys Ser Asp
 145                 150                 155                 160
 Lys Thr Gly Arg Pro Leu Glu Lys Ser Met Ser Thr Leu Asp Lys Thr
                 165                 170                 175    
 Ser Thr Ser Ser His Lys Thr Thr Thr Ser Phe His Asn Ser Gly Asn
             180                 185                 190        
 Ser Gln Thr Lys Gln Lys Ser Thr Ser Phe Pro Glu Lys Ile Thr Ala
         195                 200                 205            
 Ala Ser Lys Thr Thr Tyr Lys Thr Thr Gly Thr Pro Glu Glu Ser Glu
     210                 215                 220                
 Lys Thr Glu Asp Ser Arg Thr Thr Val Ala Ser Asp Lys Leu Leu Thr
 225                 230                 235                 240
 Lys Thr Thr Lys Asn Ile Gln Glu Thr Ile Ser Ala Asn Glu Leu Thr
                 245                 250                 255    
 Gln Ser Leu Ala Glu Pro Thr Glu His Gly Gly Arg Thr Ala Asn Glu
             260                 265                 270        
 Asn Asn Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr
         275                 280                 285            
 Ala Asn Glu Asn Thr Thr Leu Ser Pro Ala Glu Pro Thr Glu Asn Arg
     290                 295                 300                
 Glu Arg Thr Ala Asn Glu Asn Thr Ala Pro Phe Pro Ala Gly Pro Thr
 305                 310                 315                 320
 Glu Asn Arg Glu Met Thr Ala Asn Glu Asn Thr Thr Leu Phe Pro Ala
                 325                 330                 335    
 Glu Pro Thr Glu His Gly Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro
             340                 345                 350        
 Ser Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr Ala Asn Glu Asn
         355                 360                 365            
 Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro
     370                 375                 380                
 Phe Ala Asn Asp Lys Thr Thr Ser Ser Ser Ala Glu Ser Thr Glu His
 385                 390                 395                 400
 Gly Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala
                 405                 410                 415    
 Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro
             420                 425                 430        
 Ser Pro Ala Gly Pro Thr Glu Asn Arg Glu Thr Thr Ala Asn Glu Lys
         435                 440                 445            
 Thr Thr Leu Ser Pro Val Glu Pro Thr Glu Asn Arg Glu Thr Thr Ala
     450                 455                 460                
 Asn Glu Lys Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Gly Gln
 465                 470                 475                 480
 Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala Glu Pro
                 485                 490                 495    
 Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Pro
             500                 505                 510        
 Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys
         515                 520                 525            
 Thr Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Gly Asp Arg Thr Pro
     530                 535                 540                
 Leu Ala Asn Glu Lys Thr Thr Pro Ser Leu Ala Glu Pro Thr Glu Asn
 545                 550                 555                 560
 Gly Gln Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser Ser Ser Ala
                 565                 570                 575    
 Glu Pro Thr Glu His Glu Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr
             580                 585                 590        
 Thr Pro Ser Pro Ala Glu Pro Thr Glu Asn Arg Glu Arg Thr Ala Asn
         595                 600                 605            
 Glu Asn Thr Thr Pro Ser Pro Ala Gly Pro Thr Glu Asn Arg Glu Met
     610                 615                 620                
 Thr Ala Asn Glu Lys Thr Thr Leu Phe Pro Ala Glu Pro Thr Glu Asn
 625                 630                 635                 640
 Arg Glu Arg Thr Ala Asn Glu Lys Thr Thr Ser Ser Pro Ala Glu Pro
                 645                 650                 655    
 Thr Glu Asn Gly Gln Arg Thr Pro Phe Ala Asn Glu Lys Thr Thr Ser
             660                 665                 670        
 Ser Ser Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn
         675                 680                 685            
 Glu Asn Thr Thr Leu Ser Pro Ala Gly Pro Thr Glu Asn Arg Glu Arg
     690                 695                 700                
 Thr Ala Asn Glu Lys Thr Thr Pro Phe Pro Ala Glu Pro Thr Glu Asn
 705                 710                 715                 720
 Arg Glu Arg Thr Ala Asn Glu Asn Thr Thr Pro Ser Pro Ala Gln Pro
                 725                 730                 735    
 Thr Glu Asn Gly Asp Arg Thr Pro Leu Ala Asn Glu Lys Thr Thr Pro
             740                 745                 750        
 Ser Leu Ala Glu Pro Thr Glu Asn Gly Lys Arg Thr Pro Phe Ala Asn
         755                 760                 765            
 Glu Lys Thr Thr Ser Ser Ser Ala Glu Pro Thr Glu His Ala Glu Arg
     770                 775                 780                
 Thr Pro Leu Ala Asn Glu Asn Thr Thr Ser Ser Pro Ala Glu Pro Thr
 785                 790                 795                 800
 Glu Asn Arg Glu Arg Thr Ala Asn Glu Lys Thr Thr Gln Phe Pro Ala
                 805                 810                 815    
 Glu Pro Thr Glu Asn Arg Glu Ser Thr Ala Asn Glu Lys Thr Thr Pro
             820                 825                 830        
 Phe Pro Ala Glu Pro Thr Glu Asn Arg Glu Trp Thr Ala Asn Glu Asn
         835                 840                 845            
 Thr Thr Leu Ser Pro Ala Glu Pro Thr Glu His Glu Glu Met Thr Pro
     850                 855                 860                
 Leu Ala Asn Glu Lys Thr Thr Leu Ser Pro Ala Glu Pro Thr Glu Asn
 865                 870                 875                 880
 Gly Glu Arg Thr Pro Phe Thr Asn Glu Lys Thr Thr Pro Ser Ser Ala
                 885                 890                 895    
 Glu Pro Thr Glu His Gly Glu Arg Thr Pro Leu Ala Asn Glu Ile Thr
             900                 905                 910        
 Thr Pro Ser Arg Ala Glu Pro Thr Glu His Gly Glu Arg Ile Ala Asn
         915                 920                 925            
 Glu Lys Ala Thr Pro Ser Pro Ala Lys Pro Thr Glu His Gly Glu Thr
     930                 935                 940                
 Thr Val Asn Glu Asp Thr Thr Pro Ser Ser Ala Glu Pro Thr Glu Asn
 945                 950                 955                 960
 Gly Glu Arg Thr Pro Leu Ala Asn Glu Asn Thr Thr Thr Ser Pro Thr
                 965                 970                 975    
 Glu Ser Thr Glu His Gly Glu Arg Thr Ala Asn Glu Lys Thr Thr Pro
             980                 985                 990        
 Ser Pro Ala Glu Pro Thr Glu His Gly Glu Arg Thr Pro Ser Ala Asn
         995                1000                1005            
 Glu Lys Thr Ile Pro Ser Pro Ala Lys Pro Thr Glu His Glu Glu Met
    1010                1015                1020                
 Thr Pro Ser Ala Asn Glu Asn Thr Thr Pro Ser Pro Val Lys Pro Thr
1025                1030                1035                1040
 Glu His Gly Glu Lys Thr Thr Leu Ala Asn Glu Lys Ile Thr Leu Ser
                1045                1050                1055    
 Pro Glu Gly Pro Thr Glu His Gly Ala Lys Thr Thr Ser Ala Asn Glu
            1060                1065                1070        
 Lys Ile Thr Pro Ser Leu Ala Lys Pro Thr Glu His Gly Glu Arg Thr
        1075                1080                1085            
 Thr Ser Pro Asn Asp Lys Ile Thr Ser Ser Ala Ala Glu Ser Thr Glu
    1090                1095                1100                
 His Arg Asp Arg Ala Thr Ser Ala Asn Val Ile Thr Pro Ala Pro Ala
1105                1110                1115                1120
 Glu Pro Ile Lys His Ala Lys Arg Thr Thr Leu Ala His Glu Lys Met
                1125                1130                1135    
 Thr Gln Val Thr Glu Lys Ser Thr Glu His Pro Glu Lys Thr Thr Ser
            1140                1145                1150        
 Thr Thr Glu Lys Thr Thr Arg Thr Pro Glu Lys Pro Thr Leu Tyr Ser
        1155                1160                1165            
 Glu Lys Thr Ile Cys Thr Lys Gly Lys Asn Thr Pro Val Pro Glu Lys
    1170                1175                1180                
 Pro Thr Glu Asn Leu Gly Asn Thr Thr Leu Thr Thr Glu Thr Ile Lys
1185                1190                1195                1200
 Ala Pro Val Lys Ser Thr Glu Asn Pro Glu Lys Thr Ala Ala Val Thr
                1205                1210                1215    
 Lys Thr Ile Lys Pro Ser Val Lys Val Thr Gly Asp Lys Ser Leu Thr
            1220                1225                1230        
 Thr Thr Ser Ser His Leu Asn Lys Thr Glu Val Thr His Gln Val Pro
        1235                1240                1245            
 Thr Gly Ser Phe Thr Leu Ile Thr Ser Arg Thr Lys Leu Ser Ser Ile
    1250                1255                1260                
 Thr Ser Glu Ala Thr Gly Asn Glu Ser His Pro Tyr Leu Asn Lys Asp
1265                1270                1275                1280
 Gly Ser Gln Lys Gly Ile His Ala Gly Gln Met Gly Glu Asn Asp Ser
                1285                1290                1295    
 Phe Pro Ala Trp Ala Ile Val Ile Val Val Leu Val Ala Val Ile Leu
            1300                1305                1310        
 Leu Leu Val Phe Leu Gly Leu Ile Phe Leu Val Ser Tyr Met Met Arg
        1315                1320                1325            
 Thr Arg Arg Thr Leu Thr Gln Asn Thr Gln Tyr Asn Asp Ala Glu Asp
    1330                1335                1340                
 Glu Gly Gly Pro Asn Ser Tyr Pro Val Tyr Leu Met Glu Gln Gln Asn
1345                1350                1355                1360
 Leu Gly Met Gly Gln Ile Pro Ser Pro Arg
                1365                1370



      <210> 918
      <211> 49
      <212> PRT
      <213> Homo sapiens


      <400> 918
 Leu Leu Gly Asp Gln Gly Leu Pro Gly Val Phe Val Leu Tyr Glu Leu
   1               5                  10                  15    
 Ile Ile Gly Gly Met Phe Thr Val Ala Gly Leu Ile Asp Ser Leu Ile
              20                  25                  30        
 Tyr His Ser Ala Arg Ala Ile Gln Lys Lys Ile Asp Leu Gly Lys Thr
          35                  40                  45            
 Thr
    



      <210> 919
      <211> 425
      <212> PRT
      <213> Homo sapiens


      <400> 919
 Pro Pro Leu Gly Ala Gly Ala Gly Ile His Ala Arg Ser Pro His Pro
   1               5                  10                  15    
 Ala Arg Arg Leu Arg Leu Thr Ala Ala Gly Val Gly Gly Arg Ala Ser
              20                  25                  30        
 Gly Leu Leu Pro Thr Pro Trp Arg Arg His His Gly Pro Ser Gly Ala
          35                  40                  45            
 Ala Pro Tyr Pro Ala Ala Arg Leu Trp Gln Gly Pro Trp Arg Cys Arg
      50                  55                  60                
 Arg Pro Gln Pro Met Ala Gln Arg Tyr Asp Glu Leu Pro His Tyr Pro
  65                  70                  75                  80
 Gly Ile Ala Asp Gly Pro Ala Ala Leu Ala Gly Phe Pro Glu Ala Val
                  85                  90                  95    
 Pro Ala Ala Pro Gly Pro Tyr Gly Pro His Arg Pro Pro Gln Pro Leu
             100                 105                 110        
 Pro Pro Gly Leu Asp Ser Asp Gly Leu Lys Arg Asp Lys Asp Glu Ile
         115                 120                 125            
 Tyr Gly His Pro Leu Phe Pro Leu Leu Ala Leu Gly Phe Glu Lys Cys
     130                 135                 140                
 Glu Leu Ala Thr Cys Ser Pro Arg Asp Gly Ala Gly Ala Gly Leu Gly
 145                 150                 155                 160
 Thr Pro Arg Gly Gly Asp Val Cys Ser Ser Asp Ser Phe Asn Glu Asp
                 165                 170                 175    
 Asn Thr Ala Phe Ala Lys Gln Val Cys Ser Glu Arg Pro Phe Ser Ser
             180                 185                 190        
 Asn Pro Glu Leu Asp Asn Leu Met Ile Gln Ala Ile Gln Val Leu Arg
         195                 200                 205            
 Phe His Leu Leu Glu Leu Glu Lys Gly Lys Met Pro Ile Asp Leu Val
     210                 215                 220                
 Ile Glu Asp Arg Asp Gly Gly Cys Arg Glu Asp Phe Glu Asp Tyr Pro
 225                 230                 235                 240
 Ala Pro Cys Pro Ser Leu Pro Asp Gln Asn Asn Ile Trp Ile Arg Asp
                 245                 250                 255    
 His Glu Asp Ser Gly Ser Val His Leu Gly Thr Pro Gly Pro Ser Ser
             260                 265                 270        
 Gly Gly Leu Ala Ser Gln Ser Gly Asp Asn Ser Ser Asp Gln Gly Val
         275                 280                 285            
 Gly Leu Asp Thr Ser Val Ala Ser Pro Ser Ser Gly Gly Glu Asp Glu
     290                 295                 300                
 Asp Leu Asp Gln Glu Pro Arg Arg Asn Lys Lys Arg Gly Ile Phe Pro
 305                 310                 315                 320
 Lys Val Ala Thr Asn Ile Met Arg Ala Trp Leu Phe Gln His Leu Ser
                 325                 330                 335    
 His Pro Tyr Pro Ser Glu Glu Gln Lys Lys Gln Leu Ala Gln Asp Thr
             340                 345                 350        
 Gly Leu Thr Ile Leu Gln Val Asn Asn Trp Phe Ile Asn Ala Arg Arg
         355                 360                 365            
 Arg Ile Val Gln Pro Met Ile Asp Gln Ser Asn Arg Thr Gly Gln Gly
     370                 375                 380                
 Ala Ala Phe Ser Pro Glu Gly Gln Pro Ile Gly Gly Tyr Thr Glu Thr
 385                 390                 395                 400
 Glu Pro His Val Ala Phe Arg Ala Pro Ala Ser Val Gly Met Ser Leu
                 405                 410                 415    
 Asn Ser Glu Gly Glu Trp His Tyr Leu
             420                 425



      <210> 920
      <211> 231
      <212> PRT
      <213> Homo sapiens


      <400> 920
 His Leu His Arg Phe Ser Val Tyr Asn Val Arg Ser Asp Val Gln Gly
   1               5                  10                  15    
 Thr Thr Phe Pro Glu Lys Lys Arg Arg Gly Ala Gly Arg Ser Arg Arg
              20                  25                  30        
 Arg Arg Lys Glu Gly Gly Glu Gly Glu Gly Glu Gly Glu Gly Glu Glu
          35                  40                  45            
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
      50                  55                  60                
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
  65                  70                  75                  80
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu
                  85                  90                  95    
 Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu Glu
             100                 105                 110        
 Thr Val Ser Thr Pro Ser Phe Ser Gly Gln Val His Cys Leu Ala Pro
         115                 120                 125            
 Ser Ser Leu Gly Arg Gly Gly Trp Gly His Gly Ala Pro Lys Pro Pro
     130                 135                 140                
 Pro Ala Ala Leu Arg Gly Pro Gly Pro Asp Arg Tyr Leu Gly Gly Leu
 145                 150                 155                 160
 Pro Leu Leu Glu Val Phe Gln His Arg Cys Val Ala Ala Arg Pro Arg
                 165                 170                 175    
 Gly Ala Pro Leu His Arg Arg Gly Val Arg Arg Arg His Ala Ile Pro
             180                 185                 190        
 Ala Val Arg Gln Arg Arg Arg Asp Ser Glu Asp Gly Ala Ala Gly Ala
         195                 200                 205            
 Val Gly Gly Ala Arg Gly Ala Ala Val Leu Gly Val Asp His Arg Val
     210                 215                 220                
 Arg Gln Gly Gln Arg Thr Asp
 225                 230    



      <210> 921
      <211> 135
      <212> PRT
      <213> Homo sapiens


      <400> 921
 Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe Ala Ile Tyr Leu
   1               5                  10                  15    
 Met Thr Val Val Gly Asn Ile Ser Leu Val Ala Leu Ile Phe Thr His
              20                  25                  30        
 Cys Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly Asn Leu Ala Leu
          35                  40                  45            
 Val Asp Leu Ser Arg Ala Cys Ala Ile Thr Pro Lys Met Leu Glu Asn
      50                  55                  60                
 Phe Phe Ser Glu Gly Lys Arg Ile Ser Leu Tyr Glu Cys Ala Val Gln
  65                  70                  75                  80
 Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys Phe Leu Leu Ala
                  85                  90                  95    
 Ala Val Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Gln Tyr
             100                 105                 110        
 His Ile Met Met Ser Lys Lys Leu Cys Ile Gln Met Thr Thr Gly Ala
         115                 120                 125            
 Phe Ile Ala Gly Asn Leu His
     130                 135



      <210> 922
      <211> 230
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(230)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 922
 Ala Asp Val Pro Gly Ala Gln Arg Ala Val Pro Gly Asp Gly Pro Gly
   1               5                  10                  15    
 Ala Pro Gly Pro Pro Gly Leu Leu Gly Leu Arg Cys Ser Cys Asn Ser
              20                  25                  30        
 Pro Glu Ser Ala Gly Gly Cys Leu Gln Ser Ser Pro Ala Gly Ala Gly
          35                  40                  45            
 Ala Arg Asp His Leu Ala Thr Arg Cys His His Ala Gly Leu Arg Leu
      50                  55                  60                
 Pro Leu Pro Leu Ser Val Pro Ala Leu Pro Gly Thr Pro Leu His Arg
  65                  70                  75                  80
 Ala Pro Ala Gly Pro Arg Phe His Gly Pro Thr Gly His Arg Ile Pro
                  85                  90                  95    
 Ala Pro Arg Ala Ala Ala Arg Ala Cys Ser Gly Gln Leu Pro Pro Pro
             100                 105                 110        
 Leu Pro Ala Pro Pro Pro Ser Arg Leu Pro Arg Ala Leu Gln Pro Ser
         115                 120                 125            
 Pro Leu Ser Asp Val Gly Ala Pro Arg Ser Arg Gly Lys Ser Gly Pro
     130                 135                 140                
 His Gln Gly Pro Arg Pro Phe Pro His Gln Glu Arg Ser Gly Ser Asn
 145                 150                 155                 160
 Asp Pro Arg Val Lys Asn Asn Pro Asp Gly Leu Pro Ser Pro Leu Asn
                 165                 170                 175    
 Ser Ala Pro Arg Thr Xaa Ser Pro Ala Ser Ser Arg Pro Cys Pro Ala
             180                 185                 190        
 Pro His Pro Cys Leu Ser Gly Val Pro Ser Ile Pro Leu Gly Ala Ala
         195                 200                 205            
 Ala Ser Val Asp Pro Ser Ala Glu Lys Ser Pro Pro His Pro Gly Lys
     210                 215                 220                
 Pro Thr Phe Leu Ser Arg
 225                 230



      <210> 923
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 923
 Ala Pro Cys His Leu Val His Pro Tyr Thr Gln Arg Pro Pro Thr Leu
   1               5                  10                  15    
 Gln His Arg Gly Gly Ala Arg Gly Glu Leu Leu Cys Glu Gly Glu Lys
              20                  25                  30        
 Leu Gly Pro Pro Asn Arg Trp Ala Trp Leu Arg Cys Pro Cys Leu Arg
          35                  40                  45            
 Gln Gly Trp Ser Thr Cys Ser Pro Tyr Pro Thr Ala Pro Ala Pro Pro
      50                  55                  60                
 Glu His Ala Gly Thr
  65                



      <210> 924
      <211> 278
      <212> PRT
      <213> Homo sapiens


      <400> 924
 Asp Ala Trp Glu Val Leu Tyr Val Ser Gly Asn Ser Ala Glu Val Phe
   1               5                  10                  15    
 Phe Val Asp Tyr Gly Asn Lys Ser His Val Asp Leu His Leu Leu Met
              20                  25                  30        
 Glu Ile Pro Cys Gln Phe Leu Glu Leu Pro Phe Gln Ala Leu Glu Phe
          35                  40                  45            
 Lys Ile Cys Lys Met Arg Pro Ser Ala Lys Ser Leu Val Cys Gly Lys
      50                  55                  60                
 His Trp Ser Asp Gly Ala Ser Gln Trp Phe Ala Ser Leu Val Ser Gly
  65                  70                  75                  80
 Cys Thr Leu Leu Val Lys Val Phe Ser Val Val His Ser Val Leu His
                  85                  90                  95    
 Val Asp Val Tyr Gln Tyr Ser Gly Val Gln Asp Ala Ile Asn Ile Arg
             100                 105                 110        
 Asp Val Leu Ile Gln Gln Gly Tyr Ala Glu Leu Thr Glu Glu Ser Tyr
         115                 120                 125            
 Glu Ser Lys Gln Ser His Glu Val Leu Lys Gly Leu Phe Ser Lys Ser
     130                 135                 140                
 Val Glu Asn Met Thr Asp Gly Ser Val Pro Phe Pro Met Lys Asp Asp
 145                 150                 155                 160
 Glu Lys Tyr Leu Ile Arg Ile Leu Leu Glu Ser Phe Ser Thr Asn Lys
                 165                 170                 175    
 Leu Gly Thr Pro Asn Cys Lys Ala Glu Leu His Gly Pro Phe Asn Pro
             180                 185                 190        
 Tyr Glu Leu Lys Cys His Ser Leu Thr Arg Ile Ser Lys Phe Arg Cys
         195                 200                 205            
 Val Trp Ile Glu Lys Glu Ser Ile Asn Ser Val Ile Ile Ser Asp Ala
     210                 215                 220                
 Pro Glu Asp Leu His Gln Arg Met Leu Val Ala Ala Ser Leu Ser Ile
 225                 230                 235                 240
 Asn Ala Thr Gly Ser Thr Met Leu Leu Arg Glu Thr Ser Leu Met Pro
                 245                 250                 255    
 His Ile Pro Gly Leu Pro Ala Leu Leu Ser Met Leu Phe Ala Pro Val
             260                 265                 270        
 Ile Glu Leu Arg Ile Asp
         275            



      <210> 925
      <211> 391
      <212> PRT
      <213> Homo sapiens


      <400> 925
 Gly Phe Val Glu Ala Gly Glu Glu Cys Tyr Cys Val Ser Gly Gln Glu
   1               5                  10                  15    
 Cys Arg Asp Leu Cys Cys Phe Ala His Asn Cys Ser Leu Arg Pro Gly
              20                  25                  30        
 Ala Gln Cys Ala His Gly Asp Cys Cys Val Arg Cys Leu Leu Lys Pro
          35                  40                  45            
 Ala Gly Ala Leu Cys Arg Gln Ala Met Gly Asp Cys Asp Leu Pro Glu
      50                  55                  60                
 Phe Cys Thr Gly Thr Ser Ser His Cys Pro Pro Asp Val Tyr Leu Leu
  65                  70                  75                  80
 Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly Tyr Cys Trp Asp Gly Ala
                  85                  90                  95    
 Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln Leu Trp Gly Pro Gly Ser
             100                 105                 110        
 His Pro Ala Pro Glu Ala Cys Phe Gln Val Val Asn Ser Ala Gly Asp
         115                 120                 125            
 Ala His Gly Asn Cys Gly Gln Asp Ser Glu Gly His Phe Leu Pro Cys
     130                 135                 140                
 Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu Gln Cys Gln Gly Gly Lys
 145                 150                 155                 160
 Pro Ser Leu Leu Ala Pro His Met Val Pro Val Asp Ser Thr Val His
                 165                 170                 175    
 Leu Asp Gly Gln Glu Val Thr Cys Arg Gly Ala Leu Ala Leu Pro Ser
             180                 185                 190        
 Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu Val Glu Pro Gly Thr Gln
         195                 200                 205            
 Cys Gly Pro Arg Met Val Cys Gln Ser Arg Arg Cys Arg Lys Asn Ala
     210                 215                 220                
 Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala Cys His Ser His Gly Val
 225                 230                 235                 240
 Cys Asn Ser Asn His Asn Cys His Cys Ala Pro Gly Trp Ala Pro Pro
                 245                 250                 255    
 Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser Met Asp Ser Gly Pro Val
             260                 265                 270        
 Gln Ala Glu Asn His Asp Thr Phe Leu Leu Ala Met Leu Leu Ser Val
         275                 280                 285            
 Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu Ala Trp Cys Cys Tyr Arg
     290                 295                 300                
 Leu Pro Gly Ala His Leu Gln Arg Cys Ser Trp Gly Cys Arg Arg Asp
 305                 310                 315                 320
 Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro His Arg Asp His Pro Leu
                 325                 330                 335    
 Gly Gly Val His Pro Met Glu Leu Gly Pro Thr Ala Thr Gly Gln Pro
             340                 345                 350        
 Trp Pro Leu Asp Pro Glu Asn Ser His Glu Pro Ser Ser His Pro Glu
         355                 360                 365            
 Lys Pro Leu Pro Ala Val Ser Pro Asp Pro Gln Ala Asp Gln Val Gln
     370                 375                 380                
 Met Pro Arg Ser Cys Leu Trp
 385                 390    



      <210> 926
      <211> 960
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(960)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 926
 His Leu Gly Thr Pro Gly Leu Arg Arg Pro Leu Pro Asp Met Val Leu
   1               5                  10                  15    
 Pro Ala Trp Pro Thr Pro Gln Thr Pro Ala Pro Pro Ser Val Gln Gln
              20                  25                  30        
 Pro Pro Gly His Cys Ala Pro Ser Pro Gly Gln Ser Arg Pro Gly Gly
          35                  40                  45            
 Asp Gly Ser Phe Thr Leu Gly His Ala Ser Xaa Ser Gly Arg Gly Pro
      50                  55                  60                
 Gly Trp Cys Gly Ser Cys Ser Trp Gly Arg Gln Leu Gly Pro Xaa Gly
  65                  70                  75                  80
 His Arg Gln Arg Leu Arg Gln Ala Cys Val Leu Pro Pro Ala Ser Gly
                  85                  90                  95    
 Ala Gly Pro Gln His Pro Ala Ala Arg Leu Pro Cys Thr Asn Ile Thr
             100                 105                 110        
 Lys Ser Thr Ser Pro Arg Met Pro Arg Ala Pro Thr Gly Thr Thr Ser
         115                 120                 125            
 Gly Thr Gln Ser Trp Gly Thr Glu Lys Asp Ala Val Ile Ser Gly Ala
     130                 135                 140                
 Arg Thr Gln Arg Pro Ser Glu Pro Met Gly Pro Val Gly Leu Pro Pro
 145                 150                 155                 160
 Asn His Thr Gly Ser Trp Pro Thr Thr Ala Thr Lys Trp Val Ala Val
                 165                 170                 175    
 Ala Gly Ala Gly Ala Ser Cys Pro Pro Ser Cys Ser Ser Ser Gly Ser
             180                 185                 190        
 Pro Ser Pro Ser Pro His Leu Pro Ala Pro Cys Gly Ser Gly Ser Ala
         195                 200                 205            
 Pro Phe Thr Lys Pro Arg Arg Gly Cys Leu Gln Pro Pro Leu Ser Pro
     210                 215                 220                
 Arg Asn Leu Pro Ala Pro Leu Arg Arg Pro Pro Tyr Pro Pro Arg His
 225                 230                 235                 240
 Gln Pro Trp Pro Gly Val Ala Gln Leu Tyr Pro Pro Arg Leu Ala Ser
                 245                 250                 255    
 Ser Xaa Ser Pro Ala Ser Pro Leu Met Pro Gly Pro Cys Pro Pro Gln
             260                 265                 270        
 Arg Pro Val Ala Pro Ser Leu Pro Thr Ala Pro Thr Ser Xaa Gln Gly
         275                 280                 285            
 Xaa Arg Leu Leu Gln Leu Pro Gly Gln Asp Thr Leu Pro Arg Ala Gly
     290                 295                 300                
 Pro Cys Asp Arg Gly Phe Leu Cys Pro Phe Arg Leu Pro Pro Ala His
 305                 310                 315                 320
 Asp Ala Gly Gln Asp His Gly Ala Asp Ala Ala Gly Gly Arg Ala Ala
                 325                 330                 335    
 Arg Glu Arg Gly Ala Ala Ala Arg Ala Val Ala Ala Ala Cys Arg Glu
             340                 345                 350        
 Arg Leu Gly Arg Pro Ala Ala Thr Val Val Pro Gly Val Pro Ala Ala
         355                 360                 365            
 His His His Arg Gly Ala Pro Ala Ala Gln Glu Arg Ala Val Pro Phe
     370                 375                 380                
 His Pro Leu Xaa Arg Leu Ala Val Arg Gly His Arg Gln Ala Val Gly
 385                 390                 395                 400
 Arg Pro Gly Asp His Val Val Arg Gly His Pro Pro Pro Leu Trp Arg
                 405                 410                 415    
 Thr Ala Leu Gln Arg Val Leu Gly Ala Gly Gln Gln Ala Gly His Gln
             420                 425                 430        
 Ala Gly Leu Leu Pro Glu Arg Val Ala Leu Ser Ala Pro Arg Val Pro
         435                 440                 445            
 Gly Ala Ala Gly Ala Ala Gly Gly Ala Gly Pro Gly Cys Gly Ala Ala
     450                 455                 460                
 Leu Leu Val Thr Gly Arg Pro Arg Ala Gly Pro Arg Gln Pro Glu Arg
 465                 470                 475                 480
 Gln Pro Ala Gln Gly Val Trp Arg Arg Gly His His Thr Val Gly Leu
                 485                 490                 495    
 Gly Ala Ala His Gly Arg Val Leu Gly Gly Gln Ala Pro Val Arg Lys
             500                 505                 510        
 Pro Ala Gln Glu Asp Arg Ala Ala Gly Val Ala Xaa Lys Val Arg Gln
         515                 520                 525            
 Pro Ala Gly Phe His Val Arg Gly Glu Glu Gly Gly Gly Ala Ala His
     530                 535                 540                
 Arg Leu Pro Val Leu Pro Gly Asp Leu Pro Ala Ala Gln Ala Ala Arg
 545                 550                 555                 560
 Gly Ala Gly Gly His Arg Ala Gly His Val Leu Pro Gly Ala Arg Gly
                 565                 570                 575    
 Gly Arg Ala Gln Arg His Gln His Ala Ala Val Arg Gln Pro Arg Ala
             580                 585                 590        
 Leu His Leu His Pro Gly Arg Gly Pro Gln His Pro Gly Arg Val Pro
         595                 600                 605            
 Arg Glu Arg Gly Gln His Glu Gly His Gly Arg Xaa Arg Leu Pro Leu
     610                 615                 620                
 Pro Gln Pro His Cys His Ala Ala Leu Leu Cys Ala His Tyr Gly Pro
 625                 630                 635                 640
 Pro His Gln Ala Ala Val Pro Ala Arg Cys Gly Ala Glu Pro Arg Arg
                 645                 650                 655    
 Pro Val Val Pro Arg Asp Asp Ala Gln Ala Val Ala Ala Gly Gly Arg
             660                 665                 670        
 Arg Gly Arg Glu Arg Ala Ala Ala Gly Gly Ala Gly Ala Gly Gly Asp
         675                 680                 685            
 Gly Ala Arg Ala Gly Pro His Arg Arg Arg Gly Gly Ala Ala Asn Pro
     690                 695                 700                
 Gly Gly Ala Leu Leu Pro Ser Arg Arg Ala Arg Leu Pro Leu Pro Ser
 705                 710                 715                 720
 Thr Cys Pro Thr Thr Trp Cys Pro Cys Gly Ala Ser Ser Thr Pro Cys
                 725                 730                 735    
 Pro Ser Pro Ser Pro Ala Ala Ala Ala Ala Ala Ala Gly Gly Leu Trp
             740                 745                 750        
 Gly Pro His Ala Ala Pro Gly Gly Gly Val Gly Gly Ala Arg Gln Pro
         755                 760                 765            
 Val Ala Val Pro Pro Glu Leu Gly Ala Ala Val Pro Gly Gly Pro Ala
     770                 775                 780                
 Ala Asp Arg Gly Arg Ala Arg Gly Pro Arg Ala Pro Leu Gly Arg Phe
 785                 790                 795                 800
 Pro Arg Gln Gln Pro Arg Ala Ala His His Asp Gln Gly Val Ala Glu
                 805                 810                 815    
 Arg Ala Arg Pro Gly Arg Arg Pro Arg Ala Leu Arg Ala Leu Pro Gly
             820                 825                 830        
 Arg Arg Leu Pro Leu His Arg Gly Arg Gly Ala Glu Pro Ala Ala Leu
         835                 840                 845            
 His Gly Gln Pro Gly Pro Leu His Pro Arg Gly Ala Trp Val Ser Ser
     850                 855                 860                
 Glu Pro Ser Ala Arg Ser Ser Arg Pro Ala Arg Pro Ser Pro Leu Pro
 865                 870                 875                 880
 Ala Ile Pro Pro Thr Leu Pro Thr Gly Pro Thr Ala Pro Pro Gly Arg
                 885                 890                 895    
 Pro Arg Arg Ala Val Pro Gln Gly Lys Pro Ala Lys Ala Thr Thr Leu
             900                 905                 910        
 Gly Asp Leu Ala His Arg Gly Lys Leu Trp Pro Val Ala Cys Ala Leu
         915                 920                 925            
 Phe Arg Pro Gly Gln Ser Ser Pro Gly Tyr Leu Pro Tyr Glu Ser Leu
     930                 935                 940                
 Gln Gly His Trp Leu Val Thr Asp Thr Glu Ala Thr Ala Ser Ala Pro
 945                 950                 955                 960





      <210> 927
      <211> 285
      <212> PRT
      <213> Homo sapiens


      <400> 927
 Ser Ser Pro Arg Gly Ala Gly Ser Ala Thr Arg Gly Gly Gly Ala Pro
   1               5                  10                  15    
 Ser Gln Arg Gly Thr Pro Gly Ala Gly Gly Ala Gly Arg Ala Arg Gly
              20                  25                  30        
 Asn Ser Phe Thr Lys Phe Gly Asn Arg Asn Val Phe Met Lys Asp Asn
          35                  40                  45            
 Ser Ser Ser Ser Ser Thr Asp Ser Arg Ser Arg Ser Ser Ser Arg Ser
      50                  55                  60                
 Pro Thr Arg His Phe Arg Arg Ser Asp Ser His Ser Asp Ser Asp Ser
  65                  70                  75                  80
 Ser Tyr Ser Gly Asn Glu Cys His Pro Val Gly Arg Arg Asn Pro Pro
                  85                  90                  95    
 Pro Lys Gly Arg Gly Gly Arg Gly Ala His Met Asp Arg Gly Arg Gly
             100                 105                 110        
 Arg Ala Gln Arg Gly Lys Arg His Asp Leu Ala Pro Thr Lys Arg Ser
         115                 120                 125            
 Arg Lys Lys Met Ala Ala Leu Glu Cys Glu Asp Pro Glu Arg Glu Leu
     130                 135                 140                
 Lys Lys Gln Lys Arg Ala Ala Arg Phe Gln His Gly His Ser Arg Arg
 145                 150                 155                 160
 Leu Arg Leu Glu Pro Leu Val Leu Gln Met Ser Ser Leu Glu Ser Ser
                 165                 170                 175    
 Gly Ala Asp Pro Asp Trp Gln Glu Leu Gln Ile Val Gly Thr Cys Pro
             180                 185                 190        
 Asp Ile Thr Lys His Tyr Leu Arg Leu Thr Cys Ala Pro Asp Pro Ser
         195                 200                 205            
 Thr Val Arg Pro Val Ala Val Leu Lys Lys Ser Leu Cys Met Val Lys
     210                 215                 220                
 Cys His Trp Lys Glu Lys Gln Asp Tyr Ala Phe Ala Cys Glu Gln Met
 225                 230                 235                 240
 Lys Ser Ile Arg Gln Asp Leu Thr Val Gln Gly Ile Arg Thr Glu Phe
                 245                 250                 255    
 Thr Val Glu Val Tyr Glu Thr His Ala Arg Ile Ala Leu Glu Lys Gly
             260                 265                 270        
 Asp His Lys Glu Tyr Asn Gln Cys Gln Thr His Cys Ile
         275                 280                 285



      <210> 928
      <211> 355
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(355)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 928
 Gly Gly Gly His Gln Val Gly Gln Arg Pro Pro Phe Pro Gly Pro Trp
   1               5                  10                  15    
 Leu Ser Thr Gln Gly Pro Asp Ser Pro Trp Cys Xaa Arg Arg Trp His
              20                  25                  30        
 Asp Thr Gln Gln Cys Val Xaa Glu Pro Glu Gly Asp His His Arg Leu
          35                  40                  45            
 Pro Gly Arg Ala Ala Glu Gln Gln Arg Gly Gln Arg Pro His Ala Leu
      50                  55                  60                
 Gly Leu Ala Ala Gly Glu Pro Gly Gly Ser Pro Asn Arg Thr His Ala
  65                  70                  75                  80
 Pro Ala Cys Gly Gly Trp Cys Ser Ala Ala Cys Gln Pro Gly Leu Arg
                  85                  90                  95    
 Leu Pro Xaa Gln Gly Ala Asn Pro Arg Pro Pro Ala Pro His Ser His
             100                 105                 110        
 Asp Trp Arg Ala Gly Arg Arg Gly Gln Pro Ser Gln Pro Ser Gly Pro
         115                 120                 125            
 Gly Gly His Ala Gly Pro Cys Glu Ala Gly Ala Pro Gly Gly Val Leu
     130                 135                 140                
 Gly Pro Ala Leu Arg Ala Ala Ala Arg Gly His Pro His Pro Ala Phe
 145                 150                 155                 160
 Leu Arg Gln Xaa Glu Asp Gly Val Pro Asp Gly Ile Tyr Pro Pro Leu
                 165                 170                 175    
 Trp Ala Pro Xaa Gln Gly Leu Pro Arg Arg Leu Xaa Gly Arg Leu Pro
             180                 185                 190        
 Gly Pro Gly Gly Gly Arg Ala Gly Ala Pro Ala Ala Ala Pro Ala Gly
         195                 200                 205            
 Pro Ser Gly His Arg Gly Gln Arg Leu Gln Val Cys Pro Ala His Val
     210                 215                 220                
 Trp Pro Gln Ser Gly Met Xaa Gly Ala Leu Ser Cys Phe Pro Glu Thr
 225                 230                 235                 240
 Pro Ala Gly Gly Pro Ser Pro Val Leu Arg Gly Val Pro Gln His His
                 245                 250                 255    
 Leu Gln Ala Pro Asp Ala Pro Phe Pro Arg Pro Ala Gly Pro Ser Pro
             260                 265                 270        
 Gly Pro Pro Ala Cys Ser Thr Ser Arg Ala Ala Gly Arg Thr Ser Glu
         275                 280                 285            
 Leu Leu His Pro Cys Ser Pro Val Ser Thr Thr Pro Cys Pro Thr Pro
     290                 295                 300                
 Thr Pro Pro Gly Ser Pro Ala Xaa Cys Pro His Phe Thr Gly Phe Leu
 305                 310                 315                 320
 Val Leu His Ser Glu Pro Arg Gln Gln Pro Gln Val Asp Leu Asp Gln
                 325                 330                 335    
 Leu Ile Ala Gly Glu His Pro Ser Thr Gly Pro Leu Arg Trp Ala Leu
             340                 345                 350        
 Leu Thr Leu
         355



      <210> 929
      <211> 407
      <212> PRT
      <213> Homo sapiens


      <400> 929
 His Ile Arg Gly Leu Val Arg Ala Val Gln Phe Leu Leu Thr Ala Ala
   1               5                  10                  15    
 Gln Leu Lys Ala Lys Gly Glu Leu Ser Phe Glu Gln Asp Gln Leu Val
              20                  25                  30        
 Ala Gly Gly Gln Leu Gly Glu Leu His Asn Gly Thr Gln Tyr Arg Glu
          35                  40                  45            
 Val Arg Gln Phe Cys Ser Gly Ser Gly His His Leu Val Arg Phe Tyr
      50                  55                  60                
 Phe Leu Thr Arg Val Tyr Ser Glu Tyr Leu Glu Asp Val Leu Glu Glu
  65                  70                  75                  80
 Leu Thr Tyr Gly Pro Ala Pro Asp Leu Val Ile Ile Asn Ser Cys Leu
                  85                  90                  95    
 Trp Asp Leu Ser Arg Tyr Gly Arg Cys Ser Met Glu Ser Tyr Arg Glu
             100                 105                 110        
 Asn Leu Glu Arg Val Phe Val Arg Met Asp Gln Val Leu Pro Asp Ser
         115                 120                 125            
 Cys Leu Leu Val Trp Asn Met Ala Met Pro Leu Gly Glu Arg Ile Thr
     130                 135                 140                
 Gly Gly Phe Leu Leu Pro Glu Leu Gln Pro Leu Ala Gly Ser Leu Arg
 145                 150                 155                 160
 Arg Asp Val Val Glu Gly Asn Phe Tyr Ser Ala Thr Leu Ala Gly Asp
                 165                 170                 175    
 His Cys Phe Asp Val Leu Asp Leu His Phe His Phe Arg His Ala Val
             180                 185                 190        
 Gln His Arg His Arg Asp Gly Val His Trp Asp Gln His Ala His Arg
         195                 200                 205            
 His Leu Ser His Leu Leu Leu Thr His Val Ala Asp Ala Trp Gly Val
     210                 215                 220                
 Glu Leu Pro Lys Arg Gly Tyr Pro Pro Asp Pro Trp Ile Glu Asp Trp
 225                 230                 235                 240
 Ala Glu Met Asn His Pro Phe Gln Gly Ser His Arg Gln Thr Pro Asp
                 245                 250                 255    
 Phe Gly Glu His Leu Ala Leu Leu Pro Pro Pro Pro Ser Ser Leu Pro
             260                 265                 270        
 Pro Pro Met Pro Phe Pro Tyr Pro Leu Pro Gln Pro Ser Pro Pro Pro
         275                 280                 285            
 Leu Phe Pro Pro Leu Pro Gln Asp Thr Pro Phe Phe Pro Gly Gln Pro
     290                 295                 300                
 Phe Pro Pro His Glu Phe Phe Asn Tyr Asn Pro Val Glu Asp Phe Ser
 305                 310                 315                 320
 Met Pro Pro His Leu Gly Cys Gly Pro Gly Val Asn Phe Val Pro Gly
                 325                 330                 335    
 Pro Leu Pro Pro Pro Ile Pro Gly Pro Asn Pro His Gly Gln His Trp
             340                 345                 350        
 Gly Pro Val Val His Arg Gly Met Pro Arg Tyr Val Pro Asn Ser Pro
         355                 360                 365            
 Tyr His Val Arg Arg Met Gly Gly Pro Cys Arg Gln Arg Leu Arg His
     370                 375                 380                
 Ser Glu Arg Leu Ile His Thr Tyr Lys Leu Asp Arg Arg Pro Pro Ala
 385                 390                 395                 400
 His Ser Gly Thr Trp Pro Gly
                 405        



      <210> 930
      <211> 921
      <212> PRT
      <213> Homo sapiens


      <400> 930
 Met Asp Val Gly Phe Ser Arg Thr Thr Val Gln Thr Leu Ser Arg Ser
   1               5                  10                  15    
 His Cys Lys Asn Ile Lys Gln Lys Ile Ser Gln Trp Glu Gly Arg Ala
              20                  25                  30        
 Asn Gly Ile Ser Asn Pro Glu Lys Trp Cys Pro Lys Asp Phe Gly Val
          35                  40                  45            
 Arg Tyr Asn Cys His Gln Glu Ile Arg Leu Lys Lys Asn Pro Ile Ala
      50                  55                  60                
 Glu Arg Lys Ser Lys Asn Leu Asp Val Thr Ser Arg Glu Asn Val Gly
  65                  70                  75                  80
 Leu Asp Ile Asn Glu Asn Thr Lys Ser His Asp Gln Ser Glu Asn Glu
                  85                  90                  95    
 Asn Lys Lys His Glu Tyr Asp Asp Thr His Phe Phe Lys Asn Glu Ser
             100                 105                 110        
 Glu Ser Asn Trp Val Cys Ser Arg Val Lys Glu Ile Glu Ser Cys Lys
         115                 120                 125            
 Glu Asp Val Leu Asp Pro Glu Thr Ser Leu Pro Pro Gly Asn Phe Tyr
     130                 135                 140                
 Thr Ser Gln Ile Leu Trp Lys Lys Ile Glu Ala Leu Pro Pro Asp Lys
 145                 150                 155                 160
 Leu Leu Asn Leu Ala Leu Glu His Cys Asp Ser Ser Glu Lys Glu Leu
                 165                 170                 175    
 Asn Phe Arg Val Leu Asp Ser Ser Tyr Gly Ile Thr Lys Ser Leu Glu
             180                 185                 190        
 Asn Ile Tyr Ser Glu Pro Glu Gly Gln Glu Cys Gly Pro Ser Ile Asn
         195                 200                 205            
 Pro Leu Pro Lys Pro Arg Arg Thr Phe Arg Tyr Leu Ser Glu Ser Gly
     210                 215                 220                
 Val Thr Pro Tyr Lys Glu Arg Asn Cys Asp Lys Lys Tyr Cys Glu Asn
 225                 230                 235                 240
 Asn Ser Cys Ala Gln Ser Ser Leu Ala Ser Ser Gln Glu Pro Glu Pro
                 245                 250                 255    
 Lys Lys Tyr Gly Gly Lys Ile Arg Gly Arg Ser Lys Arg Lys Ser Phe
             260                 265                 270        
 Glu Phe Glu Asp Ile Gln His Phe Arg Asn Arg Asn Ser Gln Thr Ile
         275                 280                 285            
 Arg Glu Glu Leu Gly Arg Asn Ser Gly Ser Ala Leu Tyr Tyr Thr Gln
     290                 295                 300                
 Ser Glu Asp Asn Ile Tyr Glu Asp Ile Ile Tyr Pro Thr Lys Glu Asn
 305                 310                 315                 320
 Pro Tyr Glu Asp Ile Pro Val Gln Pro Leu Pro Met Trp Arg Ser Pro
                 325                 330                 335    
 Ser Ala Trp Lys Leu Pro Pro Ala Lys Ser Ala Phe Lys Ala Pro Lys
             340                 345                 350        
 Leu Pro Pro Lys Pro Gln Phe Leu His Arg Lys Thr Met Glu Val Lys
         355                 360                 365            
 Asn Ser Gln Ala Tyr Leu Arg Ser Lys Leu Thr Lys Asp Thr Thr Leu
     370                 375                 380                
 Pro Val Thr Leu Thr Glu Trp Lys Leu Phe Arg Ala Gly Glu Val Ala
 385                 390                 395                 400
 Asn Thr Lys Arg Lys Asn Leu Pro Arg Leu Val Leu Lys Ile Asp Asp
                 405                 410                 415    
 Ile Phe Glu Ser Lys Arg Gly Lys Lys Lys Val Lys Leu His Ser Tyr
             420                 425                 430        
 Thr Gly Lys Glu Leu Pro Pro Thr Lys Gly Glu Thr Ser Gly Asn Glu
         435                 440                 445            
 Ser Asp Ala Glu Tyr Leu Pro Lys Asn Arg His Lys Arg Leu Ala Gln
     450                 455                 460                
 Leu Gln Pro Ser Ser Lys Arg Asn Pro His Tyr Gln Thr Leu Glu Arg
 465                 470                 475                 480
 Asp Leu Ile Glu Leu Gln Glu Lys Gln Leu Phe Glu His Phe Cys Gly
                 485                 490                 495    
 Gly Val Ser Thr Arg Lys Lys Pro Ser Gly Ile Ser Tyr Ile Pro Gln
             500                 505                 510        
 Val Ile Gln Gln Phe Pro Gly Lys Asp Asp His Gly Tyr Lys Gln Ser
         515                 520                 525            
 Lys Asp Met Glu Glu Arg Leu Lys Val Ile Pro Lys Phe Cys Phe Pro
     530                 535                 540                
 Asp Ser Lys Asp Trp Met Pro Thr Ser Glu Leu Lys Ser Glu Thr Phe
 545                 550                 555                 560
 Ser Phe Val Leu Thr Gly Glu Asp Gly Ser Arg Trp Phe Gly Tyr Cys
                 565                 570                 575    
 Lys Lys Leu Leu Pro Val Gly Lys Gly Lys Arg Leu Pro Glu Val Tyr
             580                 585                 590        
 Cys Met Val Ser Arg Leu Gly Cys Phe Asn Leu Phe Ser Lys Ile Leu
         595                 600                 605            
 Asp Glu Val Glu Lys Arg Arg Glu Met Ser Pro Ala Leu Val Tyr Pro
     610                 615                 620                
 Phe Met Arg Ser Val Met Glu Ala Pro Phe Pro Ala Pro Gly Arg Thr
 625                 630                 635                 640
 Ile Thr Val Lys Ser Tyr Leu Pro Gly Ala Gly Asp Glu Ser Ile Glu
                 645                 650                 655    
 Leu Cys Arg Pro Leu Asp Ser Arg Leu Glu His Val Asp Phe Lys Cys
             660                 665                 670        
 Leu Phe Lys Cys Leu Ser Val Cys His Leu Ile Arg Val Cys Ala Ser
         675                 680                 685            
 Leu Leu Leu Glu Arg Arg Val Ile Phe Val Ala Asn Ser Leu Ser Thr
     690                 695                 700                
 Leu Ser Lys Cys Gly His Ala Val Val Ala Thr Leu Tyr Pro Phe Thr
 705                 710                 715                 720
 Trp Gln His Thr Tyr Ile Pro Val Leu Pro Ala Ser Met Ile Asp Ile
                 725                 730                 735    
 Val Cys Ser Pro Thr Pro Phe Leu Ile Gly Ile Leu Ser Cys Ser Leu
             740                 745                 750        
 Pro Gln Leu Gln Asp Leu Pro Ile Glu Glu Val Leu Ile Val Asp Leu
         755                 760                 765            
 Cys Ala Asp Lys Phe Leu Gln Glu Val Ser Asp Glu Asp Glu Ile Leu
     770                 775                 780                
 Pro Pro Lys Leu Gln Ala Ala Leu Met Gln Ile Leu Glu Glu Arg Asn
 785                 790                 795                 800
 Glu Ile Leu Thr Gln Glu Gln Asn Phe Ser Gln Ala Asp Val Thr Leu
                 805                 810                 815    
 Asn Ser Leu Val Ser Glu Ala Phe Val Arg Phe Phe Val Glu Leu Val
             820                 825                 830        
 Gly His Tyr Ser Leu Asn Met Thr Val Thr Glu Arg Gly Glu Arg Val
         835                 840                 845            
 Phe Gln Arg Glu Pro Phe Arg Lys Ser His Thr Ser Arg Ser Val Arg
     850                 855                 860                
 His Phe Leu Asp Leu Phe Met Glu Thr Gln Met Phe Ala Gly Phe Ile
 865                 870                 875                 880
 Gln Asp Arg Glu Leu Arg Lys Ser Gly Val Lys Gly Leu Phe Glu Ile
                 885                 890                 895    
 Arg Ala Ile Gln Tyr Leu Glu Thr Ile Pro Glu Ser Glu Pro Ser Gly
             900                 905                 910        
 Met Asn Arg Ile Leu Arg Ser Leu Gly
         915                 920    



      <210> 931
      <211> 316
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(316)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 931
 Leu Arg Val Pro Arg Ser Trp Glu Arg Val Thr Gly Gly Gly Glu Ala
   1               5                  10                  15    
 Ala Trp Val Gly Pro Gln Ile Ala Gly Ser Gly Gly Ile Ser Pro Gly
              20                  25                  30        
 Lys Pro Leu Ala Arg Leu Gln Gly Leu Pro Pro Ala Arg Ala Met Ala
          35                  40                  45            
 Ala Glu Asn Ser Lys Gln Phe Trp Lys Arg Ser Ala Lys Leu Pro Gly
      50                  55                  60                
 Ser Ile Gln Pro Val Tyr Gly Ala Gln His Pro Pro Leu Asp Pro Arg
  65                  70                  75                  80
 Leu Thr Lys Asn Phe Ile Lys Glu Arg Ser Lys Val Asn Thr Val Pro
                  85                  90                  95    
 Leu Lys Asn Lys Lys Ala Ser Ser Phe His Glu Phe Ala Arg Asn Thr
             100                 105                 110        
 Ser Asp Ala Trp Asp Ile Gly Asp Asp Glu Glu Glu Asp Phe Ser Ser
         115                 120                 125            
 Pro Ser Phe Gln Thr Leu Asn Ser Lys Val Ala Leu Ala Thr Ala Ala
     130                 135                 140                
 Gln Val Leu Glu Asn His Ser Met Leu Arg Val Lys Pro Glu Arg Ser
 145                 150                 155                 160
 Gln Ser Thr Thr Ser Asp Val Pro Ala Asn Tyr Thr Gly His Lys Ala
                 165                 170                 175    
 Gln His Xaa Cys Pro Ala Val Gln Lys Leu Xaa Xaa Tyr Met Pro Glu
             180                 185                 190        
 Glu Pro Ser Ser Thr Asn Ser Asn His Ser Leu Ser Gly Pro Ser Ser
         195                 200                 205            
 Pro Ser Leu Pro Glu Ile Ser Asp Gln Asn Ala Ser Gly Ala Pro Pro
     210                 215                 220                
 Met Thr Val Arg Glu Lys Thr Arg Leu Glu Lys Phe Arg Gln Leu Leu
 225                 230                 235                 240
 Ser Ser Gln Asn Thr Asp Leu Asp Glu Leu Arg Lys Cys Ser Trp Pro
                 245                 250                 255    
 Gly Val Pro Arg Glu Val Arg Pro Ile Thr Trp Arg Leu Leu Ser Gly
             260                 265                 270        
 Tyr Leu Pro Ala Asn Thr Glu Arg Arg Lys Leu Thr Leu Gln Arg Lys
         275                 280                 285            
 Arg Glu Glu Tyr Phe Gly Phe Ile Glu Gln Tyr Tyr Asp Ser Arg Asn
     290                 295                 300                
 Glu Glu His His Gln Asp Thr Tyr Arg Gln Cys Ile
 305                 310                 315    



      <210> 932
      <211> 197
      <212> PRT
      <213> Homo sapiens


      <400> 932
 Asn Ser Trp Val Glu Gln Leu Arg Gly Asn Val Leu Leu Asn Gly Leu
   1               5                  10                  15    
 Ser Leu Glu Ala Asp Ile Thr Ala Asn Leu Asp Ser Pro Arg Val Thr
              20                  25                  30        
 Val Ala Gln Leu Asp Trp Asp Val Ala Thr Val His Gln Leu Ser Ala
          35                  40                  45            
 Phe Gln Pro Asp Val Val Ile Thr Ala Asp Val Leu Tyr Cys Pro Glu
      50                  55                  60                
 Ala Ile Val Ser Leu Val Gly Ile Leu Arg Arg Leu Ala Ala Cys Arg
  65                  70                  75                  80
 Glu His Gln Gln Ala Pro Glu Val Tyr Val Ala Phe Thr Val His Asn
                  85                  90                  95    
 Pro Glu Thr Cys Gln Leu Phe Thr Thr Glu Leu Gly Gln Gly Gly Ile
             100                 105                 110        
 Ile Trp Gly Ser Gly Ser Ser Phe Met Thr Arg Asn Cys Phe Pro Met
         115                 120                 125            
 Gly Glu His Leu Glu Met Gly Asn Ala Glu Ser His Pro Val Gly Leu
     130                 135                 140                
 Thr His Asp Ser Asn Gly Ile Val Arg Ile Lys Ser Leu Ser Trp Glu
 145                 150                 155                 160
 Glu Phe Leu Tyr Gly Lys Ala Asp Lys Thr Phe Ile Gly Leu Glu Cys
                 165                 170                 175    
 Leu Glu Asn Val Asn Phe Gln Ile Arg Asn His Lys Leu Pro Ser Asn
             180                 185                 190        
 Lys Thr Ser Ala Ile
         195        



      <210> 933
      <211> 425
      <212> PRT
      <213> Homo sapiens


      <400> 933
 Lys Asp Phe Leu Lys Val Thr Trp Trp Glu Arg Thr Arg Thr Leu Leu
   1               5                  10                  15    
 Phe Ser Thr Glu Lys Lys Glu Thr Lys Asn Phe Arg Arg Lys Ile Thr
              20                  25                  30        
 His Gly Ala Ala Ala Leu Asn Ser Lys Gly Glu Ser His Ser Arg Pro
          35                  40                  45            
 Asn Thr Glu Asp Met Ser Leu Cys His Ala Asn Arg Ser Ala Ala Leu
      50                  55                  60                
 Phe His Leu Gly Gln Asn Glu Thr Cys Leu Lys Asp Ile Asn Arg Ala
  65                  70                  75                  80
 Gln Thr His Gly Tyr Ala Glu Arg Leu Gln Pro Lys Ile Met Leu Arg
                  85                  90                  95    
 Lys Ala Glu Cys Leu Val Ala Leu Gly Arg Leu Gln Glu Ala Ser Gln
             100                 105                 110        
 Thr Ile Ser Asp Leu Glu Arg Asn Phe Thr Ala Thr Pro Ala Leu Ala
         115                 120                 125            
 Asp Val Leu Pro Gln Thr Leu Gln Arg Asn Leu His Arg Leu Lys Met
     130                 135                 140                
 Lys Met Gln Glu Lys Asp Ser Leu Thr Glu Ser Phe Pro Ala Ala Leu
 145                 150                 155                 160
 Ala Lys Thr Leu Glu Asp Ala Ala Leu Arg Glu Glu Asn Glu Gln Leu
                 165                 170                 175    
 Ser Asn Ala Ser Ser Ser Ile Gly Leu Cys Val Asp Pro Leu Lys Gly
             180                 185                 190        
 Arg Cys Leu Val Ala Thr Lys Asp Ile Leu Pro Gly Glu Leu Leu Val
         195                 200                 205            
 Gln Glu Asp Ala Phe Val Ser Val Leu Asn Pro Gly Glu Leu Pro Pro
     210                 215                 220                
 Pro His His Gly Leu Asp Ser Lys Trp Asp Thr Arg Val Thr Asn Gly
 225                 230                 235                 240
 Asp Leu Tyr Cys His Arg Cys Leu Lys His Thr Leu Ala Thr Val Pro
                 245                 250                 255    
 Cys Asp Gly Cys Ser Tyr Ala Lys Tyr Cys Ser Gln Glu Cys Leu Gln
             260                 265                 270        
 Gln Ala Trp Glu Leu Tyr His Arg Thr Glu Cys Pro Leu Gly Gly Leu
         275                 280                 285            
 Leu Leu Thr Leu Gly Val Phe Cys His Ile Ala Gln Arg Leu Thr Leu
     290                 295                 300                
 Leu Val Gly Phe Glu Asp Val Arg Lys Ile Ile Thr Lys Leu Cys Asp
 305                 310                 315                 320
 Lys Ile Ser Asn Lys Asp Ile Cys Leu Arg Glu Ser Asn Asn Gln Val
                 325                 330                 335    
 Lys Thr Leu Asn Tyr Gly Leu Gly Glu Ser Glu Lys Asn Gly Asn Ile
             340                 345                 350        
 Val Glu Thr Pro Ile Pro Gly Cys Asp Ile Asn Gly Lys Tyr Glu Asn
         355                 360                 365            
 Asn Tyr Asn Ala Val Phe Asn Leu Leu Pro His Thr Glu Asn His Ser
     370                 375                 380                
 Pro Glu His Lys Phe Leu Cys Ala Leu Cys Val Ser Ala Leu Cys Arg
 385                 390                 395                 400
 Gln Leu Glu Ala Ala Ser Leu Gln Ala Ser Gln Ser Thr Gly Ile Thr
                 405                 410                 415    
 Gly Val Ser His Arg Ala Arg Pro Lys
             420                 425



      <210> 934
      <211> 697
      <212> PRT
      <213> Homo sapiens


      <400> 934
 Met Leu Val Leu Asn Ser Trp Ala Gln Val Ile His Trp Pro Gln Pro
   1               5                  10                  15    
 Pro Lys Val Leu Gly Leu Gln Pro Leu Glu Lys Thr Gln Tyr Gly Phe
              20                  25                  30        
 Leu Gly Thr Asp Arg Val Glu Glu Lys Thr Ser Val Ile Thr Ile Arg
          35                  40                  45            
 Val Ser Val Thr His Arg His Asn Ser Tyr Met Glu Ala Glu Asn Leu
      50                  55                  60                
 Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly Leu Ser Asp Asp Pro Glu
  65                  70                  75                  80
 Leu Gln Pro Val Leu Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr
                  85                  90                  95    
 Val Leu Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His
             100                 105                 110        
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp
         115                 120                 125            
 Ile Cys Phe Ile Ser Thr Thr Val Pro Lys Met Leu Val Ser Ile Gln
     130                 135                 140                
 Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly Cys Leu Thr Gln Val Tyr
 145                 150                 155                 160
 Phe Leu Met Met Phe Ala Gly Met Asp Thr Phe Leu Leu Ala Val Met
                 165                 170                 175    
 Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Thr Val
             180                 185                 190        
 Ile Met Asn Pro Cys Leu Cys Gly Leu Leu Val Leu Ala Ser Trp Phe
         195                 200                 205            
 Ile Ile Phe Trp Phe Ser Leu Val His Ile Leu Leu Met Lys Arg Leu
     210                 215                 220                
 Thr Phe Ser Thr Gly Thr Glu Ile Pro His Phe Phe Cys Glu Pro Ala
 225                 230                 235                 240
 Gln Val Leu Lys Val Ala Cys Ser Asn Thr Leu Leu Asn Asn Ile Val
                 245                 250                 255    
 Leu Tyr Val Ala Thr Ala Leu Leu Gly Val Phe Pro Val Ala Gly Ile
             260                 265                 270        
 Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser Leu Met Gly Met Ser Ser
         275                 280                 285            
 Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Cys
     290                 295                 300                
 Val Val Ser Leu Phe Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser
 305                 310                 315                 320
 Ala Val Thr His Ser Ser Gln Ser Ser Ser Thr Ala Ser Val Met Tyr
                 325                 330                 335    
 Ala Met Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn
             340                 345                 350        
 Lys Asp Val Lys Gly Ala Leu Glu Arg Leu Leu Ser Arg Ala Asp Ser
         355                 360                 365            
 Cys Leu Leu Arg Cys Pro Ser Tyr Thr Glu Pro Gln Asn Leu Thr Gly
     370                 375                 380                
 Val Ser Glu Phe Leu Leu Leu Gly Leu Ser Glu Asp Pro Glu Leu Gln
 385                 390                 395                 400
 Pro Val Leu Ala Gly Leu Phe Leu Ser Met Tyr Leu Val Thr Val Leu
                 405                 410                 415    
 Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His Leu His
             420                 425                 430        
 Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly
         435                 440                 445            
 Phe Thr Ser Thr Thr Val Pro Lys Met Ile Val Asp Met Gln Thr His
     450                 455                 460                
 Ser Arg Val Ile Ser Tyr Glu Gly Cys Leu Thr Gln Met Ser Phe Phe
 465                 470                 475                 480
 Val Leu Phe Ala Cys Met Asp Asp Met Leu Leu Ser Val Met Ala Tyr
                 485                 490                 495    
 Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Arg Ile Ile Met
             500                 505                 510        
 Asn Pro Arg Leu Cys Gly Phe Leu Ile Leu Leu Ser Phe Phe Ile Ser
         515                 520                 525            
 Leu Leu Asp Ser Gln Leu His Asn Leu Ile Met Leu Gln Leu Thr Cys
     530                 535                 540                
 Phe Lys Asp Val Asp Ile Ser Asn Phe Phe Cys Asp Pro Ser Gln Leu
 545                 550                 555                 560
 Leu His Leu Arg Cys Ser Asp Thr Phe Ile Asn Glu Met Val Ile Tyr
                 565                 570                 575    
 Phe Met Gly Ala Ile Phe Gly Cys Leu Pro Ile Ser Gly Ile Leu Phe
             580                 585                 590        
 Ser Tyr Tyr Lys Ile Val Ser Pro Ile Leu Arg Val Pro Thr Ser Asp
         595                 600                 605            
 Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val
     610                 615                 620                
 Cys Leu Phe Tyr Gly Thr Gly Leu Val Gly Tyr Leu Ser Ser Ala Val
 625                 630                 635                 640
 Leu Pro Ser Pro Arg Lys Ser Met Val Ala Ser Val Met Tyr Thr Val
                 645                 650                 655    
 Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp
             660                 665                 670        
 Ile Gln Ser Ala Leu Cys Arg Leu His Gly Arg Ile Ile Lys Ser His
         675                 680                 685            
 His Leu His Pro Phe Cys Tyr Met Gly
     690                 695        



      <210> 935
      <211> 314
      <212> PRT
      <213> Homo sapiens


      <400> 935
 Met Asp Glu Leu Ser Glu Leu Arg Glu Phe Tyr Asp Pro Asp Thr Val
   1               5                  10                  15    
 Glu Leu Met Asn Trp Ile Asn Asn Tyr Thr Leu Gly Lys Gly Ser Thr
              20                  25                  30        
 Val His Lys Ala Gln Ser Lys Cys Leu Asp Leu Leu Thr Val Gly Leu
          35                  40                  45            
 Ile Gln Thr Leu Lys Ser Phe Ser Ser Asn Thr Pro Arg Lys Ala Val
      50                  55                  60                
 Phe Ala Gly Ser Met Gln Leu Leu Ala Gly Val Lys Leu Cys Thr Gly
  65                  70                  75                  80
 Arg Thr Leu Thr Asn His Pro His Tyr Glu Asp Ser Ser Leu Arg Glu
                  85                  90                  95    
 Arg Thr Arg Ala Val Pro Thr Thr Ser Cys Gly Thr Ser Arg Cys Asp
             100                 105                 110        
 Leu Gly Gly Asp Thr Ala Lys Pro Tyr Gln Arg Gly Asn Gln Asn Val
         115                 120                 125            
 Ser Ala Gln Gly Ser His Leu Leu Val Gln Asp Leu Cys Leu Pro Ile
     130                 135                 140                
 Ser Thr Lys Asp Val Pro Leu Asp His Arg Ser Ser Pro Gly Arg Asp
 145                 150                 155                 160
 Leu Cys Leu Pro Ile Ser Thr Lys Asp Pro Gln Asn Leu Gly Arg Ser
                 165                 170                 175    
 Val Cys Ile His Pro Leu Arg Val Cys Gly Thr Gly Met Asn Val Lys
             180                 185                 190        
 Gly Ala Ser Cys Gly Val Ala His Gly Val Leu Gln Val Ala Leu Thr
         195                 200                 205            
 Pro Arg Met Asp Glu Arg Glu Arg Ser Ser Gly Val Ser Gln Leu Ala
     210                 215                 220                
 Glu Met Arg Ser Ser Ser Gln Val Ala Phe Ala Thr Leu His Phe Tyr
 225                 230                 235                 240
 Val Phe Leu Lys Val Tyr Gln Ile Tyr Ala Lys Arg Ala Pro Glu Glu
                 245                 250                 255    
 Val His Ala Leu Leu Arg Ser Phe Gly Thr Asp Tyr Val Ile Leu Glu
             260                 265                 270        
 Asp Ser Ile Cys Tyr Glu Arg Arg His Arg Arg Gly Cys Arg Leu Arg
         275                 280                 285            
 Asp Leu Leu Asp Ile Ala Asn Gly His Val Ser Met Leu Pro Leu Pro
     290                 295                 300                
 Val Trp Gly Ser Pro Gly Gly Ala Gly Leu
 305                 310                



      <210> 936
      <211> 184
      <212> PRT
      <213> Homo sapiens


      <400> 936
 Phe Val Gly Arg Leu Leu Arg Leu Gly Glu Ala Leu Arg Leu Arg Pro
   1               5                  10                  15    
 Asp Pro Ser Gly Gly Cys Arg Leu Gln Pro Ala Leu Val Gly Glu Thr
              20                  25                  30        
 Glu Met Ser Glu Lys Glu Asn Asn Phe Pro Pro Leu Pro Lys Phe Ile
          35                  40                  45            
 Pro Val Lys Pro Cys Phe Tyr Gln Asn Phe Ser Asp Glu Ile Pro Val
      50                  55                  60                
 Glu His Gln Val Leu Val Lys Arg Ile Tyr Arg Leu Trp Met Phe Tyr
  65                  70                  75                  80
 Cys Ala Thr Leu Gly Val Asn Leu Ile Ala Cys Leu Ala Trp Trp Ile
                  85                  90                  95    
 Gly Gly Gly Ser Gly Thr Asn Phe Gly Leu Ala Phe Val Trp Leu Leu
             100                 105                 110        
 Leu Phe Thr Pro Cys Gly Tyr Val Cys Trp Phe Arg Pro Val Tyr Lys
         115                 120                 125            
 Ala Phe Arg Ala Asp Ser Ser Phe Asn Phe Met Ala Phe Phe Phe Ile
     130                 135                 140                
 Phe Arg Thr Gln Phe Val Leu Thr Val Ile Gln Ala Ile Gly Phe Ser
 145                 150                 155                 160
 Gly Trp Gly Ala Cys Gly Trp Leu Ser Ala Ile Gly Phe Phe Gln Tyr
                 165                 170                 175    
 Ser Pro Gly Ala Ala Val Val Met
             180                



      <210> 937
      <211> 564
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(564)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 937
 Phe Val Arg Glu Ile Arg Gly Pro Ala Val Pro Arg Leu Thr Ser Ala
   1               5                  10                  15    
 Glu Asp Arg His Arg His Gly Pro His Ala His Ser Pro Glu Leu Gln
              20                  25                  30        
 Arg Thr Gly Arg Asp Tyr Ser Leu Asp Tyr Leu Pro Phe Arg Leu Trp
          35                  40                  45            
 Val Gly Ile Trp Val Ala Thr Phe Cys Leu Val Leu Val Ala Thr Glu
      50                  55                  60                
 Ala Ser Val Leu Val Arg Tyr Phe Thr Arg Phe Thr Glu Glu Gly Phe
  65                  70                  75                  80
 Cys Ala Leu Ile Ser Leu Ile Phe Ile Tyr Asp Ala Val Gly Lys Met
                  85                  90                  95    
 Leu Asn Leu Thr His Thr Tyr Pro Ile Gln Lys Pro Gly Ser Ser Ala
             100                 105                 110        
 Tyr Gly Cys Leu Cys Gln Tyr Pro Gly Pro Gly Gly Asn Glu Ser Gln
         115                 120                 125            
 Trp Ile Arg Thr Arg Pro Lys Asp Arg Asp Asp Ile Val Ser Met Asp
     130                 135                 140                
 Leu Gly Leu Ile Asn Ala Ser Leu Leu Pro Pro Pro Glu Cys Thr Arg
 145                 150                 155                 160
 Gln Gly Gly His Pro Arg Gly Pro Gly Cys His Thr Val Pro Asp Ile
                 165                 170                 175    
 Ala Phe Phe Ser Leu Leu Leu Phe Leu Thr Ser Phe Phe Phe Ala Met
             180                 185                 190        
 Ala Leu Lys Cys Val Lys Thr Ser Arg Phe Phe Pro Ser Val Val Arg
         195                 200                 205            
 Lys Gly Leu Ser Asp Phe Ser Ser Val Leu Ala Ile Leu Leu Gly Cys
     210                 215                 220                
 Gly Leu Asp Ala Phe Leu Gly Leu Ala Thr Pro Lys Leu Met Val Pro
 225                 230                 235                 240
 Arg Glu Phe Lys Pro Thr Leu Pro Gly Arg Gly Trp Leu Val Ser Pro
                 245                 250                 255    
 Phe Gly Ala Asn Pro Trp Trp Trp Ser Val Ala Ala Ala Leu Pro Ala
             260                 265                 270        
 Leu Leu Leu Ser Ile Leu Ile Phe Met Asp Gln Gln Ile Thr Ala Val
         275                 280                 285            
 Ile Leu Asn Arg Met Glu Tyr Arg Leu Gln Lys Gly Ala Gly Phe His
     290                 295                 300                
 Leu Asp Leu Phe Trp Val Ala Val Leu Met Leu Leu Thr Ser Ala Leu
 305                 310                 315                 320
 Gly Leu Pro Trp Tyr Val Ser Ala Thr Val Ile Ser Leu Ala His Met
                 325                 330                 335    
 Asp Ser Leu Arg Arg Glu Ser Arg Ala Cys Ala Pro Gly Glu Arg Pro
             340                 345                 350        
 Asn Phe Leu Gly Ile Arg Glu Gln Arg Leu Thr Gly Leu Val Val Phe
         355                 360                 365            
 Ile Leu Thr Gly Ala Ser Ile Phe Leu Ala Pro Val Leu Lys Phe Ile
     370                 375                 380                
 Pro Met Pro Val Leu Tyr Gly Ile Phe Leu Tyr Met Gly Val Ala Ala
 385                 390                 395                 400
 Leu Ser Ser Ile Gln Phe Thr Asn Arg Val Lys Leu Leu Leu Met Pro
                 405                 410                 415    
 Ala Lys His Gln Pro Asp Leu Leu Leu Leu Arg His Val Pro Leu Thr
             420                 425                 430        
 Arg Val His Leu Phe Thr Ala Ile Ser Phe Ala Cys Leu Gly Leu Leu
         435                 440                 445            
 Trp Ile Ile Lys Ser Thr Pro Ala Ala Ile Ile Phe Pro Leu Met Leu
     450                 455                 460                
 Leu Gly Leu Val Gly Val Arg Lys Ala Leu Glu Arg Val Phe Ser Pro
 465                 470                 475                 480
 Gln Glu Leu Leu Trp Leu Asp Glu Leu Met Pro Glu Glu Glu Arg Ser
                 485                 490                 495    
 Ile Pro Glu Lys Gly Leu Glu Pro Glu His Ser Phe Ser Gly Ser Asp
             500                 505                 510        
 Ser Glu Asp Ser Glu Leu Met Tyr Gln Pro Lys Ala Pro Glu Ile Asn
         515                 520                 525            
 Ile Ser Val Asn Xaa Leu Glu Xaa Glu Leu Asp Pro Tyr Leu Ser Tyr
     530                 535                 540                
 Pro Glu Ala Trp Val Leu Cys Leu Arg Val Pro Leu Pro Ile Pro Arg
 545                 550                 555                 560
 Pro Arg Arg Lys
                



      <210> 938
      <211> 136
      <212> PRT
      <213> Homo sapiens


      <400> 938
 Ser Ser Lys Tyr Gln His Glu Gly Phe Tyr Phe Val Glu Thr Pro Leu
   1               5                  10                  15    
 Ala Leu Ala Ala Trp Thr Asn Gln Pro Glu Ile Gly Gln Leu Leu Met
              20                  25                  30        
 Glu His Glu Gln Thr Asp Ile Thr Ser Arg Asp Ser Arg Gly Asn Asn
          35                  40                  45            
 Ile Leu His Ala Leu Val Thr Val Ala Glu Asp Phe Lys Thr Gln Asn
      50                  55                  60                
 Asp Phe Val Lys Arg Met Tyr Asp Met Ile Leu Leu Arg Ser Gly Asn
  65                  70                  75                  80
 Trp Glu Leu Glu Thr Thr Arg Asn Asn Asp Gly Leu Thr Pro Leu Gln
                  85                  90                  95    
 Leu Ala Ala Lys Met Gly Lys Ala Glu Ile Leu Lys Tyr Ile Leu Ser
             100                 105                 110        
 Arg Glu Ile Lys Glu Lys Arg Leu Arg Ser Leu Ser Arg Lys Phe Thr
         115                 120                 125            
 Asp Trp Ala Tyr Gly Pro Val Ser
     130                 135    



      <210> 939
      <211> 142
      <212> PRT
      <213> Homo sapiens


      <400> 939
 Ser Arg Phe Arg Arg Trp Leu Ser Pro Arg Phe Ala Ser Ala Ala Ala
   1               5                  10                  15    
 Leu Gly Ser Ser Gln Leu Arg Glu Gln Leu Leu Gln Cys Pro Gly Val
              20                  25                  30        
 Ala Met Gly Ala Pro His Trp Trp Asp Gln Leu Gln Ala Gly Ser Ser
          35                  40                  45            
 Glu Val Asp Trp Cys Glu Asp Asn Tyr Thr Ile Val Pro Ala Ile Ala
      50                  55                  60                
 Glu Phe Tyr Asn Thr Ile Ser Asn Val Leu Phe Phe Ile Leu Pro Pro
  65                  70                  75                  80
 Ile Cys Met Cys Leu Phe Arg Gln Tyr Ala Thr Cys Phe Asn Ser Gly
                  85                  90                  95    
 Ile Tyr Leu Ile Trp Thr Leu Leu Val Val Val Gly Ile Gly Ser Val
             100                 105                 110        
 Tyr Phe His Ala Thr Leu Ser Phe Leu Gly Gln Met Leu Asp Glu Leu
         115                 120                 125            
 Ala Val Pro Trp Val Leu Met Cys Ala Leu Ala Met Trp Phe
     130                 135                 140        



      <210> 940
      <211> 430
      <212> PRT
      <213> Homo sapiens


      <400> 940
 Leu Gln Gln Arg Thr Leu Arg Ile Thr Ala Val Gly Gln Thr His Pro
   1               5                  10                  15    
 Ile Ala Trp Met Ala Trp Glu Pro Ser Leu Gly Ala Phe Tyr Gly Pro
              20                  25                  30        
 Ala Ser Phe Ile Thr Phe Val Asn Cys Met Tyr Phe Leu Ser Ile Phe
          35                  40                  45            
 Ile Gln Leu Lys Arg His Pro Glu Arg Lys Tyr Glu Leu Lys Glu Pro
      50                  55                  60                
 Thr Glu Glu Gln Gln Arg Leu Ala Ala Asn Glu Asn Gly Glu Ile Asn
  65                  70                  75                  80
 His Gln Asp Ser Met Ser Leu Ser Leu Ile Ser Thr Ser Ala Leu Glu
                  85                  90                  95    
 Asn Glu His Thr Phe His Ser Gln Leu Leu Gly Ala Ser Leu Thr Leu
             100                 105                 110        
 Leu Leu Tyr Val Ala Leu Trp Met Phe Gly Ala Leu Ala Val Ser Leu
         115                 120                 125            
 Tyr Tyr Pro Leu Asp Leu Val Phe Ser Phe Val Phe Gly Ala Thr Ser
     130                 135                 140                
 Leu Ser Phe Ser Ala Phe Phe Val Val His His Cys Val Asn Arg Glu
 145                 150                 155                 160
 Asp Val Arg Leu Ala Trp Ile Met Thr Cys Cys Pro Gly Arg Ser Ser
                 165                 170                 175    
 Tyr Ser Val Gln Val Asn Val Gln Pro Pro Asn Ser Asn Gly Thr Asn
             180                 185                 190        
 Gly Glu Ala Pro Lys Cys Pro Asn Ser Ser Ala Glu Ser Ser Cys Thr
         195                 200                 205            
 Asn Lys Ser Ala Ser Ser Phe Lys Asn Ser Ser Gln Gly Cys Lys Leu
     210                 215                 220                
 Thr Asn Leu Gln Ala Ala Ala Ala Gln Cys His Ala Asn Ser Leu Pro
 225                 230                 235                 240
 Leu Asn Ser Thr Pro Gln Leu Asp Asn Ser Leu Thr Glu His Ser Met
                 245                 250                 255    
 Asp Asn Asp Ile Lys Met His Val Ala Pro Leu Glu Val Gln Phe Arg
             260                 265                 270        
 Thr Asn Val His Ser Ser Arg His His Lys Asn Arg Ser Lys Gly His
         275                 280                 285            
 Arg Ala Ser Arg Leu Thr Val Leu Arg Glu Tyr Ala Tyr Asp Val Pro
     290                 295                 300                
 Thr Ser Val Glu Gly Ser Val Gln Asn Gly Leu Pro Lys Ser Arg Leu
 305                 310                 315                 320
 Gly Asn Asn Glu Gly His Ser Arg Ser Arg Arg Ala Tyr Leu Ala Tyr
                 325                 330                 335    
 Arg Glu Arg Gln Tyr Asn Pro Pro Gln Gln Asp Ser Ser Asp Ala Cys
             340                 345                 350        
 Ser Thr Leu Pro Lys Ser Ser Arg Asn Phe Glu Lys Pro Val Ser Thr
         355                 360                 365            
 Thr Ser Lys Lys Asp Ala Leu Arg Lys Pro Ala Val Val Glu Leu Glu
     370                 375                 380                
 Asn Gln Gln Lys Ser Tyr Gly Leu Asn Leu Ala Ile Gln Asn Gly Pro
 385                 390                 395                 400
 Ile Lys Ser Asn Gly Gln Glu Gly Pro Leu Leu Gly Thr Asp Ser Thr
                 405                 410                 415    
 Gly Asn Val Arg Thr Gly Leu Trp Lys His Glu Thr Thr Val
             420                 425                 430



      <210> 941
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 941
 Ile Leu Gly Thr Val Tyr Leu Leu Leu Glu Asn His Leu Cys Val Gln
   1               5                  10                  15    
 Glu Thr Ala Val Ser Cys Glu Ser Phe Ile Met Glu Ser Ala Asn Gly
              20                  25                  30        
 Trp His Asp Ile Met Phe Gln Leu Glu Phe Phe Met Pro Leu Gly Ile
          35                  40                  45            
 Ile Leu Phe Cys Ser Phe Lys Ile Val Trp Ser Leu Arg Arg Arg Gln
      50                  55                  60                
 Gln Leu Ala Arg Gln Ala Arg Met Lys Lys Ala Thr Arg Phe Ile Met
  65                  70                  75                  80
 Val Val Ala Ile Val Phe Ile Thr Cys Tyr Leu Pro Ser Val Ser Ala
                  85                  90                  95    
 Arg Leu Tyr Phe Leu Trp Thr Val Pro Ser Ser Ala Cys Asp Pro Ser
             100                 105                 110        
 Val His Gly Ala Leu His Ile Thr Leu Ser Phe Thr Tyr Met Asn Ser
         115                 120                 125            
 Met Leu Asp Pro Leu Val Tyr Tyr Phe Ser Ser Pro Ser Phe Pro Lys
     130                 135                 140                
 Phe Tyr Asn Lys Leu Lys Ile Cys Ser Leu Lys Pro Lys Gln Pro Gly
 145                 150                 155                 160
 His Ser Lys Thr Gln Arg Pro Glu Glu Met Pro Ile Ser Asn Leu Gly
                 165                 170                 175    
 Arg Arg Ser Cys Ile Ser Val Ala Asn Ser Phe Gln Ser Gln Ser Asp
             180                 185                 190        
 Gly Gln Trp Asp Pro His Ile Val Glu Trp His
         195                 200            



      <210> 942
      <211> 136
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(136)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 942
 Phe Phe Phe Phe Leu Arg Trp Ser Phe Ala Val Val Ala Gln Ala Val
   1               5                  10                  15    
 Val Gln Trp His Asn Leu Ser Ser Leu Pro Phe Gly Phe Lys Gln Phe
              20                  25                  30        
 Ser Cys Leu Ser Leu Pro Gly Gly Trp Asp Cys Arg Arg Pro Pro Leu
          35                  40                  45            
 Arg Pro Ala Asp Phe Leu Tyr Phe Trp Trp Arg Arg Gly Phe Ala Val
      50                  55                  60                
 Phe Ala Arg Met Val Ser Ile Ser Xaa Pro Arg Asp Leu Pro Ala Ser
  65                  70                  75                  80
 Ala Ser Gln Ala Gly Ile Thr Gly Val Ser His Arg Ala Trp Pro Lys
                  85                  90                  95    
 Tyr Ile Thr Leu Ser Val Ile Asn Thr Leu Ala Asp His His His Arg
             100                 105                 110        
 Gly Thr Asp Phe Gly Gly Ser Pro Trp Leu His Val Ile Ile Ala Phe
         115                 120                 125            
 Pro Thr Ser Tyr Lys Val Val Ile
     130                 135    



      <210> 943
      <211> 221
      <212> PRT
      <213> Homo sapiens


      <400> 943
 Arg Thr Pro Leu Pro Val Thr Arg Asn Leu Pro Arg Ala Ile Phe Ile
   1               5                  10                  15    
 Ser Ile Pro Leu Val Thr Phe Val Tyr Thr Phe Thr Asn Ile Ala Tyr
              20                  25                  30        
 Phe Thr Ala Met Ser Pro Gln Glu Leu Leu Ser Ser Asn Ala Gly Ala
          35                  40                  45            
 Val Thr Phe Gly Glu Lys Leu Leu Gly Tyr Phe Ser Trp Val Met Pro
      50                  55                  60                
 Val Ser Val Ala Leu Ser Thr Phe Gly Gly Ile Asn Gly Tyr Leu Phe
  65                  70                  75                  80
 Thr Tyr Ser Arg Leu Cys Phe Ser Gly Ala Arg Glu Gly His Leu Pro
                  85                  90                  95    
 Ser Leu Leu Ala Met Ile His Val Arg His Cys Thr Pro Ile Pro Ala
             100                 105                 110        
 Leu Leu Val Trp Pro Ile Lys Val Asn Leu Leu Ile Pro Val Ala Tyr
         115                 120                 125            
 Leu Val Phe Trp Ala Phe Leu Leu Val Phe Ser Phe Ile Ser Glu His
     130                 135                 140                
 Met Val Cys Gly Val Gly Val Ile Ile Ile Leu Thr Gly Val Pro Ile
 145                 150                 155                 160
 Phe Phe Leu Gly Val Phe Trp Arg Ser Lys Pro Lys Cys Val His Arg
                 165                 170                 175    
 Leu Thr Glu Ser Met Thr His Trp Gly Gln Glu Leu Cys Phe Val Val
             180                 185                 190        
 Tyr Pro Gln Asp Ala Pro Glu Glu Glu Glu Asn Gly Pro Cys Pro Pro
         195                 200                 205            
 Ser Leu Leu Pro Ala Thr Asp Lys Pro Ser Lys Pro Gln
     210                 215                 220    



      <210> 944
      <211> 456
      <212> PRT
      <213> Homo sapiens


      <400> 944
 Asp Ala Trp Ala Gly Thr Asn Met Ala Ala Leu Ala Pro Val Gly Ser
   1               5                  10                  15    
 Pro Ala Ser Arg Gly Pro Arg Leu Ala Ala Gly Leu Arg Leu Leu Pro
              20                  25                  30        
 Met Leu Gly Leu Leu Gln Leu Leu Ala Glu Pro Gly Leu Gly Arg Val
          35                  40                  45            
 His His Leu Ala Leu Lys Asp Asp Val Arg His Lys Val His Leu Asn
      50                  55                  60                
 Thr Phe Gly Phe Phe Lys Asp Gly Tyr Met Val Val Asn Val Ser Ser
  65                  70                  75                  80
 Leu Ser Leu Asn Glu Pro Glu Asp Lys Asp Val Thr Ile Gly Phe Ser
                  85                  90                  95    
 Leu Asp Arg Thr Lys Asn Asp Gly Phe Ser Ser Tyr Leu Asp Glu Asp
             100                 105                 110        
 Val Asn Tyr Cys Ile Leu Lys Lys Gln Ser Val Ser Val Thr Leu Leu
         115                 120                 125            
 Ile Leu Asp Ile Ser Arg Ser Glu Val Arg Val Lys Ser Pro Pro Glu
     130                 135                 140                
 Ala Gly Thr Gln Leu Pro Lys Ile Ile Phe Ser Arg Asp Glu Lys Val
 145                 150                 155                 160
 Leu Gly Gln Ser Gln Glu Pro Asn Val Asn Pro Ala Ser Ala Gly Asn
                 165                 170                 175    
 Gln Thr Gln Lys Thr Gln Asp Gly Gly Lys Ser Lys Arg Ser Thr Val
             180                 185                 190        
 Asp Ser Lys Ala Met Gly Glu Lys Ser Phe Ser Val His Asn Asn Gly
         195                 200                 205            
 Gly Ala Val Ser Phe Gln Phe Phe Phe Asn Ile Ser Thr Asp Asp Gln
     210                 215                 220                
 Glu Gly Leu Tyr Ser Leu Tyr Phe His Lys Cys Leu Gly Lys Glu Leu
 225                 230                 235                 240
 Pro Ser Asp Lys Phe Thr Phe Ser Leu Asp Ile Glu Ile Thr Glu Lys
                 245                 250                 255    
 Asn Pro Asp Ser Tyr Leu Ser Ala Gly Glu Ile Pro Leu Pro Lys Leu
             260                 265                 270        
 Tyr Ile Ser Met Ala Phe Phe Phe Phe Leu Ser Gly Thr Ile Trp Ile
         275                 280                 285            
 His Ile Leu Arg Lys Arg Arg Asn Asp Val Phe Lys Ile His Trp Leu
     290                 295                 300                
 Met Ala Ala Leu Pro Phe Thr Lys Ser Leu Ser Leu Val Phe His Ala
 305                 310                 315                 320
 Ile Asp Tyr His Tyr Ile Ser Ser Gln Gly Phe Pro Ile Glu Gly Trp
                 325                 330                 335    
 Ala Val Val Tyr Tyr Ile Thr His Leu Leu Lys Gly Ala Leu Leu Phe
             340                 345                 350        
 Ile Thr Ile Ala Leu Ile Gly Thr Gly Trp Ala Phe Ile Lys His Ile
         355                 360                 365            
 Leu Ser Asp Lys Asp Lys Lys Ile Phe Met Ile Val Ile Pro Arg Arg
     370                 375                 380                
 Val Leu Ala Asn Val Ala Tyr Ile Ile Ile Glu Ser Thr Glu Glu Gly
 385                 390                 395                 400
 Thr Thr Glu Tyr Gly Leu Trp Lys Asp Ser Leu Phe Leu Val Asp Leu
                 405                 410                 415    
 Leu Cys Cys Gly Ala Ile Leu Phe Pro Val Val Trp Ser Ile Arg His
             420                 425                 430        
 Leu Gln Glu Ala Ser Ala Thr Asp Gly Lys Gly Lys Phe Ser Arg Ala
         435                 440                 445            
 His Phe Val Leu Leu Ser Leu Leu
     450                 455    



      <210> 945
      <211> 137
      <212> PRT
      <213> Homo sapiens


      <400> 945
 Thr Ile Ala Asn Pro Thr Asp Val Leu Lys Ile Arg Met Gln Ala Gln
   1               5                  10                  15    
 Gly Ser Leu Phe Gln Gly Ser Met Ile Gly Ser Phe Ile Asp Ile Tyr
              20                  25                  30        
 Gln Gln Glu Gly Thr Arg Gly Leu Trp Arg Ser Val Val Pro Thr Ala
          35                  40                  45            
 Gln His Ala Ala Ile Val Val Gly Val Glu Leu Pro Val Tyr Asp Phe
      50                  55                  60                
 Thr Lys Lys His Leu Ile Leu Ser Gly Met Met Glu Asp Thr Thr Leu
  65                  70                  75                  80
 Thr His Phe Val Ser Ser Phe Thr Tyr Gly Leu Ala Gly Ala Leu Ala
                  85                  90                  95    
 Ser Asn Pro Gly Asp Val Ala Gly Thr His Val Met Asn Gln Arg Ala
             100                 105                 110        
 Ile Val Gly His Val Asp Leu Tyr Lys Gly Thr Leu Asp Gly Ile Leu
         115                 120                 125            
 Lys Met Trp Lys His Glu Gly Phe Phe
     130                 135        



      <210> 946
      <211> 84
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(84)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 946
 Lys Met Gly Pro Leu Ser Ser Ser Ser Leu Pro Glu Ala Glu Cys Pro
   1               5                  10                  15    
 Asp Pro Arg Ala Ala Thr Leu Gly Met Asn Lys Met Leu His Ser His
              20                  25                  30        
 Trp Val Ser Ser Ile Ala Pro Val Asp Pro Gly Met Gly Xaa Lys Ala
          35                  40                  45            
 Ala Ser Gly Pro Asp Phe Glu Thr Gly Gln Ala Glu Ala Arg Leu Ser
      50                  55                  60                
 Pro Pro Pro Ser Leu Gln Glu Ser Ser Val Trp Pro Gly Asp Phe Pro
  65                  70                  75                  80
 His Gln Ile Cys
                



      <210> 947
      <211> 349
      <212> PRT
      <213> Homo sapiens


      <400> 947
 Met Gly Ile Thr Cys Trp Ile Ala Leu Tyr Ala Val Glu Ala Leu Pro
   1               5                  10                  15    
 Thr Cys Pro Phe Ser Cys Lys Cys Asp Ser Arg Ser Leu Glu Val Asp
              20                  25                  30        
 Cys Ser Gly Leu Gly Leu Thr Thr Val Pro Pro Asp Val Pro Ala Ala
          35                  40                  45            
 Thr Arg Thr Leu Leu Leu Leu Asn Asn Lys Leu Ser Ala Leu Pro Ser
      50                  55                  60                
 Trp Ala Phe Ala Asn Leu Ser Ser Leu Gln Arg Leu Asp Leu Ser Asn
  65                  70                  75                  80
 Asn Phe Leu Asp Arg Leu Pro Arg Ser Ile Phe Gly Asp Leu Thr Asn
                  85                  90                  95    
 Leu Thr Glu Leu Gln Leu Arg Asn Asn Ser Ile Arg Thr Leu Asp Arg
             100                 105                 110        
 Asp Leu Leu Arg His Ser Pro Leu Leu Arg His Leu Asp Leu Ser Ile
         115                 120                 125            
 Asn Gly Leu Ala Gln Leu Pro Pro Gly Leu Phe Asp Gly Leu Leu Ala
     130                 135                 140                
 Leu Arg Ser Leu Ser Leu Arg Ser Asn Arg Leu Gln Asn Leu Asp Arg
 145                 150                 155                 160
 Leu Thr Phe Glu Pro Leu Ala Asn Leu Gln Leu Leu Gln Val Gly Asp
                 165                 170                 175    
 Asn Pro Trp Glu Cys Asp Cys Asn Leu Arg Glu Phe Lys His Trp Met
             180                 185                 190        
 Glu Trp Phe Ser Tyr Arg Gly Gly Arg Leu Asp Gln Leu Ala Cys Thr
         195                 200                 205            
 Leu Pro Lys Glu Leu Arg Gly Lys Asp Met Arg Met Val Pro Met Glu
     210                 215                 220                
 Met Phe Asn Tyr Cys Ser Gln Leu Glu Asp Glu Asn Ser Ser Ala Gly
 225                 230                 235                 240
 Leu Asp Ile Pro Gly Pro Pro Cys Thr Lys Ala Ser Pro Glu Pro Ala
                 245                 250                 255    
 Lys Pro Lys Pro Gly Ala Glu Pro Glu Pro Glu Pro Ser Thr Ala Cys
             260                 265                 270        
 Pro Gln Lys Gln Arg His Arg Pro Ala Ser Val Arg Arg Ala Met Gly
         275                 280                 285            
 Thr Val Ile Ile Ala Gly Val Val Cys Gly Val Val Cys Ile Met Met
     290                 295                 300                
 Val Val Ala Ala Ala Tyr Gly Cys Ile Tyr Ala Ser Leu Met Ala Lys
 305                 310                 315                 320
 Tyr His Arg Glu Leu Lys Lys Arg Gln Pro Leu Met Gly Asp Pro Glu
                 325                 330                 335    
 Gly Glu His Glu Asp Gln Lys Gln Ile Ser Ser Val Ala
             340                 345                



      <210> 948
      <211> 116
      <212> PRT
      <213> Homo sapiens


      <400> 948
 Met Cys Leu Leu Cys Cys Glu Cys Leu Phe His Leu Trp Lys Arg Ile
   1               5                  10                  15    
 Asn Trp Trp Gln Gly Phe Cys Ser Phe Tyr Leu Leu Leu Trp Val Gly
              20                  25                  30        
 Leu Leu Ser Phe Pro Pro Asp Pro Pro Trp Lys Ser Phe Thr Pro Ala
          35                  40                  45            
 Ile Leu Phe Leu Ala Trp Gly Thr Gly Ser Ser Pro Gly Arg His Arg
      50                  55                  60                
 Phe Ser Leu Pro Thr Asp Arg Arg Pro Ser Ala His Ser Pro Phe Leu
  65                  70                  75                  80
 Ser Thr Leu Gln His Ser Ile Arg Thr Leu Phe His Ser Pro Ile Arg
                  85                  90                  95    
 Ser Ser Arg Phe Ala Phe Val Ser Ser Leu His Ser Tyr Thr Ser Ile
             100                 105                 110        
 Pro Ser Leu Pro
         115    



      <210> 949
      <211> 206
      <212> PRT
      <213> Homo sapiens


      <400> 949
 Phe Arg Gly Arg Ser Gly Ser Ala Ala Gly Ala Ala Ala Gly Thr Ala
   1               5                  10                  15    
 Ala Leu His His Arg Ile Met Ser Gly Gln Leu Glu Arg Cys Glu Arg
              20                  25                  30        
 Glu Trp His Glu Leu Glu Gly Glu Phe Gln Glu Leu Gln Glu Thr His
          35                  40                  45            
 Arg Ile Tyr Lys Gln Lys Leu Glu Glu Leu Ala Ala Leu Gln Thr Leu
      50                  55                  60                
 Cys Ser Ser Ser Ile Ser Lys Gln Lys Lys His Leu Lys Asp Leu Lys
  65                  70                  75                  80
 Leu Thr Leu Gln Arg Cys Lys Arg His Ala Ser Arg Glu Glu Ala Glu
                  85                  90                  95    
 Leu Val Gln Gln Met Ala Ala Asn Ile Lys Glu Arg Gln Asp Val Phe
             100                 105                 110        
 Phe Asp Met Glu Ala Tyr Leu Pro Lys Lys Asn Gly Leu Tyr Leu Asn
         115                 120                 125            
 Leu Val Leu Gly Asn Val Asn Val Thr Leu Leu Ser Asn Gln Ala Lys
     130                 135                 140                
 Phe Ala Tyr Lys Asp Glu Tyr Glu Lys Phe Lys Leu Tyr Leu Thr Ile
 145                 150                 155                 160
 Ile Leu Leu Leu Gly Ala Val Ala Cys Arg Phe Val Leu His Tyr Arg
                 165                 170                 175    
 Val Thr Asp Glu Val Phe Asn Phe Leu Leu Val Trp Tyr Tyr Cys Thr
             180                 185                 190        
 Leu Thr Ile Arg Glu Ser Ile Leu Ile Ser Asn Gly Ser Arg
         195                 200                 205    



      <210> 950
      <211> 1097
      <212> PRT
      <213> Homo sapiens


      <400> 950
 Met Cys Gly Pro Arg Arg Leu Ala Ala Pro Gly Ser Ser Leu Gly Ser
   1               5                  10                  15    
 Phe Gly Arg Ala Ser Arg Gly Gly Arg Arg Gly Ser Ser Gly Gly Arg
              20                  25                  30        
 Ala Ala Glu Pro Gly Leu Gly Asp Thr Met Arg Arg Val Leu Arg Leu
          35                  40                  45            
 Leu Leu Gly Cys Phe Leu Thr Glu Leu Cys Ala Arg Val Cys Arg Ala
      50                  55                  60                
 Gln Glu Arg Ala Gly His Gly Gln Leu Ala Gln Leu Gly Gly Val Leu
  65                  70                  75                  80
 Leu Leu Ala Gly Gly Asn Arg Ser Gly Ala Ala Ser Gly Glu Ala Ser
                  85                  90                  95    
 Glu Gly Ala Glu Ala Ser Asp Ala Pro Pro Thr Arg Ala Pro Thr Pro
             100                 105                 110        
 Asp Phe Cys Arg Gly Tyr Phe Asp Val Met Gly Gln Trp Asp Pro Pro
         115                 120                 125            
 Phe Asn Cys Ser Ser Gly Asp Phe Ile Phe Cys Cys Gly Thr Cys Gly
     130                 135                 140                
 Phe Arg Phe Cys Cys Thr Phe Lys Lys Arg Arg Leu Asn Gln Ser Thr
 145                 150                 155                 160
 Cys Thr Asn Tyr Asp Thr Pro Leu Trp Leu Asn Thr Gly Lys Pro Pro
                 165                 170                 175    
 Ala Arg Lys Asp Asp Pro Leu His Asp Pro Thr Lys Asp Lys Thr Asn
             180                 185                 190        
 Leu Ile Val Tyr Ile Ile Cys Gly Val Val Ala Val Met Val Leu Val
         195                 200                 205            
 Gly Ile Phe Thr Lys Leu Gly Leu Glu Lys Ala His Arg Pro Gln Arg
     210                 215                 220                
 Glu His Met Ser Ser Leu Ser Ala Gly Gly Cys His Arg Glu Ala Asn
 225                 230                 235                 240
 Phe Gly Leu Glu His Gly Glu Gly Ala Leu Gly Ser Ala Gln Gly Val
                 245                 250                 255    
 Ser Leu Ser Arg Ser Arg Ser Pro Ala Cys Ser Pro Leu Leu Ala Asn
             260                 265                 270        
 Pro Thr Val Ser Ala Pro Ala Ser Val Ala Thr Phe Leu Thr Ser Met
         275                 280                 285            
 Asp Leu Ala Leu Ser Phe Val Ser Leu Thr Lys Gly Ser Lys Ser Gly
     290                 295                 300                
 Ser Ser Asn Asp Leu Ile Asn Glu Phe Asn Ser Pro Gln Cys Met Leu
 305                 310                 315                 320
 Cys Thr Asp Asp Arg Asn Pro Trp Glu Ile Ala His Glu Gly His Ile
                 325                 330                 335    
 Asp Ala Leu Ile Arg Arg Leu Ile Glu Gln His Asn Val Pro Leu His
             340                 345                 350        
 Val Ala Tyr Arg Val Ala Ser Trp Ser Thr Ala Arg His Phe Gly Leu
         355                 360                 365            
 Asn His Leu Gly Leu Leu Ala Pro Gly Lys Gln Ala Asp Ile Val Leu
     370                 375                 380                
 Leu Ser Asp Ala Arg Lys Val Thr Val Gln Gln Val Leu Val Lys Gly
 385                 390                 395                 400
 Glu Pro Ile Asp Ala Gln Thr Leu Gln Ala Glu Glu Ser Ala Arg Leu
                 405                 410                 415    
 Ala Gln Ser Ala Pro Pro Tyr Gly Asn Thr Ile Ala Arg Gln Pro Val
             420                 425                 430        
 Ser Ala Ser Asp Phe Ala Leu Gln Phe Thr Pro Gly Lys Arg Tyr Arg
         435                 440                 445            
 Val Ile Asp Val Ile His Asn Glu Leu Ile Thr His Ser His Ser Ser
     450                 455                 460                
 Val Tyr Ser Glu Asn Gly Phe Asp Arg Asp Asp Val Ser Phe Ile Ala
 465                 470                 475                 480
 Val Leu Glu Arg Tyr Gly Gln Arg Leu Ala Pro Ala Cys Gly Leu Leu
                 485                 490                 495    
 Gly Gly Phe Gly Leu Asn Glu Gly Ala Leu Ala Ala Thr Val Ser His
             500                 505                 510        
 Asp Ser His Asn Ile Val Val Ile Gly Arg Ser Ala Glu Glu Met Ala
         515                 520                 525            
 Leu Ala Val Asn Gln Val Ile Gln Asp Gly Gly Gly Leu Cys Val Val
     530                 535                 540                
 Arg Asn Gly Gln Lys Leu Leu Phe Arg Ile Pro Ser Phe Ser Ile Ile
 545                 550                 555                 560
 Ser Gly Phe Val Cys Glu Ile Ile Ala Thr Leu Thr Ala Leu Val Phe
                 565                 570                 575    
 Arg Phe Asn His Arg Arg Cys Phe Gly Asn Ser Val Leu Gly Thr His
             580                 585                 590        
 Asn His Ala Ala Asp Asn Gly Ile Val Glu Ala Glu Gly Ser Phe Gln
         595                 600                 605            
 Leu Ile Asp His Phe Leu Arg Ser Phe Asn Ile His Gln Asn Val Val
     610                 615                 620                
 Cys Phe Val Gln Phe Val Asp Arg Val Ser Gln Leu Thr Ala Ala Pro
 625                 630                 635                 640
 Val Phe Gln Thr Val Asp Leu Ala Phe Cys Thr Ser Asp Gly Ser Ser
                 645                 650                 655    
 Val Ala Leu Asp His Ala Arg Asn Leu Phe Ala Leu Thr Glu Gly Asn
             660                 665                 670        
 Lys Ile Lys Asn Arg Arg Glu Glu Lys His Arg Cys Arg Gly Gln Ser
         675                 680                 685            
 Lys Leu Asn Ile Ile Ile Asp Asn Val Val Lys Ala Val Asn Gly Gly
     690                 695                 700                
 Lys Ser Gln Arg Glu Gln Ala Glu Phe Ala Asp Cys Ile Thr Phe Gly
 705                 710                 715                 720
 Ile Arg His Asn Thr Ser Pro Lys Met Ser Arg Leu Leu Phe Val Met
                 725                 730                 735    
 Glu Ile Thr Ile Phe Asp Gly Asp Phe Glu Asn His Phe Phe Asp Arg
             740                 745                 750        
 Val Ile Ala Asp Lys Pro Ile Arg Phe Met Asp Ile Ala Asn Asn Asp
         755                 760                 765            
 Leu Pro Phe Val Asp Leu Asn Glu Gln Leu Asp Lys Tyr Val Ala Asn
     770                 775                 780                
 Gly Gly Lys Arg Ser Asp Trp Thr Val Lys Phe Ala Glu Asn Arg Ser
 785                 790                 795                 800
 Gln Asp Gly Thr Leu Leu Gly Tyr Ser Leu Leu Gln Glu Ser Val Asp
                 805                 810                 815    
 Gln Ala Ser Tyr Met Tyr Ser Asp Asn His Tyr Leu Ala Glu Met Ala
             820                 825                 830        
 Thr Ile Leu Gly Lys Pro Glu Glu Ala Lys Arg Tyr Arg Gln Leu Ala
         835                 840                 845            
 Gln Gln Leu Ala Asp Tyr Ile Asn Thr Cys Met Phe Asp Pro Thr Thr
     850                 855                 860                
 Gln Phe Tyr Tyr Asp Val Arg Ile Glu Asp Lys Pro Leu Ala Asn Gly
 865                 870                 875                 880
 Cys Ala Gly Lys Pro Ile Val Glu Arg Gly Lys Gly Pro Glu Gly Trp
                 885                 890                 895    
 Ser Pro Leu Phe Asn Gly Ala Ala Thr Gln Ala Asn Ala Asp Ala Val
             900                 905                 910        
 Val Lys Val Met Leu Asp Pro Lys Glu Phe Asn Thr Phe Val Pro Leu
         915                 920                 925            
 Gly Thr Ala Ala Leu Thr Asn Pro Ala Phe Gly Ala Asp Ile Tyr Trp
     930                 935                 940                
 Arg Gly Arg Val Trp Val Asp Gln Phe Trp Phe Gly Leu Lys Gly Met
 945                 950                 955                 960
 Glu Arg Tyr Gly Tyr Arg Asp Asp Ala Leu Lys Leu Ala Asp Thr Phe
                 965                 970                 975    
 Phe Arg His Ala Lys Gly Leu Thr Ala Asp Gly Pro Ile Gln Glu Asn
             980                 985                 990        
 Tyr Asn Pro Leu Thr Gly Ala Gln Gln Ala His Gln Met Ser Val Arg
         995                1000                1005            
 Glu Leu Tyr Thr Asp Val Ile Glu Glu Phe Tyr Trp Val Ala Leu Pro
    1010                1015                1020                
 Leu Thr Thr Gln Asn Ser Leu Ser Gln Tyr Gln Pro Glu Trp Gln Cys
1025                1030                1035                1040
 Trp Glu Pro Asp Val Glu Trp Pro Gly Met Thr Phe Glu Gln Phe Val
                1045                1050                1055    
 Arg Glu Phe Ala Glu Trp Ile Ser Leu Ser Ile His Tyr Cys Tyr Pro
            1060                1065                1070        
 Glu Tyr Ala His Lys Val Phe His Arg Gln Tyr Trp Arg Asn Lys Trp
        1075                1080                1085            
 Ala Thr Ser Ser Asp Leu Ala Ile Pro
    1090                1095        



      <210> 951
      <211> 232
      <212> PRT
      <213> Homo sapiens


      <400> 951
 Ala Trp Gly Phe Tyr Met Asp Leu Trp Lys Ala Val Tyr Leu Pro Asn
   1               5                  10                  15    
 Gly Arg Asn Pro Ser Phe Leu Ile Ser Ser Trp His Arg Asp Thr Phe
              20                  25                  30        
 Gly Pro Gln Lys Asp Ser Ser Gln Val Glu Glu Gly Asp Asp Val Leu
          35                  40                  45            
 Asp Lys Leu Leu Glu Asn Ile Gly His Thr Ser Pro Glu Cys Leu Leu
      50                  55                  60                
 Pro Ser Gln Leu Asn Leu Asn Glu Pro Ser Leu Thr Pro Cys Gly Met
  65                  70                  75                  80
 Asn Tyr Asp Gln Glu Lys Glu Ile Ile Glu Val Ile Leu Arg Gln Asn
                  85                  90                  95    
 Ala Gln Glu Asp Glu Tyr Ile Gln Ser His Asn Phe Asp Ser Ala Met
             100                 105                 110        
 Lys Val Thr Ser Gln Gly Gln Pro Ser Pro Val Glu Pro Arg Gly Pro
         115                 120                 125            
 Phe Tyr Phe Cys Arg Leu Leu Leu Asp Asp Leu Gly Met Asn Ser Trp
     130                 135                 140                
 Asp Arg Arg Lys Asn Phe His Leu Leu Lys Lys Asn Ser Lys Leu Leu
 145                 150                 155                 160
 Arg Glu Leu Lys Asn Leu Asp Ser Arg Gln Cys Arg Glu Thr His Lys
                 165                 170                 175    
 Ile Ala Val Phe Tyr Ile Ala Glu Gly Gln Glu Asp Lys Cys Ser Ile
             180                 185                 190        
 Leu Ser Asn Glu Arg Gly Ser Gln Ala Tyr Glu Asp Phe Val Ala Gly
         195                 200                 205            
 Leu Gly Trp Glu Val Met His Phe Ile Gln Glu Val Phe Ile Asp Gln
     210                 215                 220                
 His Cys Leu Lys Met Cys Pro Asn
 225                 230        



      <210> 952
      <211> 131
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(131)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 952
 Arg Trp Cys Pro Phe Pro Leu Ser Lys Pro His Gly Pro Pro Ala Gly
   1               5                  10                  15    
 Gln Leu Xaa Pro Gly Pro Ser Cys Glu Gln Thr Glu Pro Pro Ser Pro
              20                  25                  30        
 Val Asn Val Thr Val Thr His Leu Arg Ala Asn Ser Ala Thr Val Ser
          35                  40                  45            
 Trp Asp Val Pro Glu Gly Asn Ile Val Ile Gly Tyr Ser Ile Ser Gln
      50                  55                  60                
 Gln Arg Asn Gly Pro Gly Gln Arg Val Ile Arg Glu Val Asn Thr Thr
  65                  70                  75                  80
 Thr Arg Ala Cys Ala Leu Trp Gly Leu Ala Glu Asp Ser Asp Tyr Thr
                  85                  90                  95    
 Val Gln Val Arg Ser Ile Gly Leu Arg Gly Glu Ser Pro Pro Gly Pro
             100                 105                 110        
 Arg Val His Phe Arg Thr Leu Lys Gly Ser Asp Arg Leu Pro Ser Asn
         115                 120                 125            
 Ser Ser Ser
     130    



      <210> 953
      <211> 26
      <212> PRT
      <213> Homo sapiens


      <400> 953
 Pro Lys Leu Ser Val Tyr Pro Leu Gln Ser His His Cys Leu Ser Glu
   1               5                  10                  15    
 Pro Phe Gln Ser Leu Val Cys Cys Leu Ala
              20                  25    



      <210> 954
      <211> 128
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(128)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 954
 Gln Thr Ala Leu Phe Phe Arg Val Ala Glu Trp Asp Ser Thr Glu Lys
   1               5                  10                  15    
 Ile Gly Asp Leu Phe Val Ala Ser Phe Ser Lys Thr Met Ala Leu Glu
              20                  25                  30        
 Val Tyr Arg Asp Tyr Val Asn Asn Phe Thr Ser Ala Met Ser Ile Ile
          35                  40                  45            
 Lys Lys Gly Cys Leu Thr Lys Pro Ala Phe Leu Glu Tyr Leu Lys Arg
      50                  55                  60                
 Arg Xaa Val Cys Ser Pro Tyr Arg Val Thr Leu Tyr Gly Leu Met Val
  65                  70                  75                  80
 Lys Pro Ile Gln Arg Phe Pro Gln Phe Ile Leu Leu Leu Gln Asp Met
                  85                  90                  95    
 Leu Lys Asn Thr Pro Arg Gly His Pro Asp Arg Leu Ser Leu Gln Leu
             100                 105                 110        
 Ala Leu Thr Glu Leu Glu Thr Leu Ala Glu Lys Leu Asn Glu Gln Lys
         115                 120                 125            





      <210> 955
      <211> 90
      <212> PRT
      <213> Homo sapiens


      <400> 955
 Glu Phe Pro Ser Leu Thr Gly Thr Gly Asp Trp Arg Thr Phe Val Ser
   1               5                  10                  15    
 Phe Ser Pro Gln Gly Leu Val His Ser Tyr Arg Leu Leu Trp His Lys
              20                  25                  30        
 Pro Gly Trp Asn Met Ala Arg Gln Leu Cys His Ala Thr Leu Asp Thr
          35                  40                  45            
 Gln Arg Cys Tyr Ser Thr Arg Lys Val Leu Ile Tyr Leu Ala Gly Ser
      50                  55                  60                
 Ser Ser Ser Trp Pro Glu Thr Gln Ile Pro Arg Lys Gly Trp Trp Ala
  65                  70                  75                  80
 Leu Ser Pro His Pro Glu Thr Ile Gln Ser
                  85                  90



      <210> 956
      <211> 697
      <212> PRT
      <213> Homo sapiens


      <400> 956
 Met Leu Val Leu Asn Ser Trp Ala Gln Val Ile His Trp Pro Gln Pro
   1               5                  10                  15    
 Pro Lys Val Leu Gly Leu Gln Pro Leu Glu Lys Thr Gln Tyr Gly Phe
              20                  25                  30        
 Leu Gly Thr Asp Arg Val Glu Glu Lys Thr Ser Val Ile Thr Ile Arg
          35                  40                  45            
 Val Ser Val Thr His Arg His Asn Ser Tyr Met Glu Ala Glu Asn Leu
      50                  55                  60                
 Thr Glu Leu Ser Lys Phe Leu Leu Leu Gly Leu Ser Asp Asp Pro Glu
  65                  70                  75                  80
 Leu Gln Pro Val Leu Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr
                  85                  90                  95    
 Val Leu Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His
             100                 105                 110        
 Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Val Asp
         115                 120                 125            
 Ile Cys Phe Ile Ser Thr Thr Val Pro Lys Met Leu Val Ser Ile Gln
     130                 135                 140                
 Ala Arg Ser Lys Asp Ile Ser Tyr Met Gly Cys Leu Thr Gln Val Tyr
 145                 150                 155                 160
 Phe Leu Met Met Phe Ala Gly Met Asp Thr Phe Leu Leu Ala Val Met
                 165                 170                 175    
 Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Thr Val
             180                 185                 190        
 Ile Met Asn Pro Cys Leu Cys Gly Leu Leu Val Leu Ala Ser Trp Phe
         195                 200                 205            
 Ile Ile Phe Trp Phe Ser Leu Val His Ile Leu Leu Met Lys Arg Leu
     210                 215                 220                
 Thr Phe Ser Thr Gly Thr Glu Ile Pro His Phe Phe Cys Glu Pro Ala
 225                 230                 235                 240
 Gln Val Leu Lys Val Ala Cys Ser Asn Thr Leu Leu Asn Asn Ile Val
                 245                 250                 255    
 Leu Tyr Val Ala Thr Ala Leu Leu Gly Val Phe Pro Val Ala Gly Ile
             260                 265                 270        
 Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser Leu Met Gly Met Ser Ser
         275                 280                 285            
 Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Cys
     290                 295                 300                
 Val Val Ser Leu Phe Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser
 305                 310                 315                 320
 Ala Val Thr His Ser Ser Gln Ser Ser Ser Thr Ala Ser Val Met Tyr
                 325                 330                 335    
 Ala Met Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn
             340                 345                 350        
 Lys Asp Val Lys Gly Ala Leu Glu Arg Leu Leu Ser Arg Ala Asp Ser
         355                 360                 365            
 Cys Leu Leu Arg Cys Pro Ser Tyr Thr Glu Pro Gln Asn Leu Thr Gly
     370                 375                 380                
 Val Ser Glu Phe Leu Leu Leu Gly Leu Ser Glu Asp Pro Glu Leu Gln
 385                 390                 395                 400
 Pro Val Leu Ala Gly Leu Phe Leu Ser Met Tyr Leu Val Thr Val Leu
                 405                 410                 415    
 Gly Asn Leu Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His Leu His
             420                 425                 430        
 Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly
         435                 440                 445            
 Phe Thr Ser Thr Thr Val Pro Lys Met Ile Val Asp Met Gln Thr His
     450                 455                 460                
 Ser Arg Val Ile Ser Tyr Glu Gly Cys Leu Thr Gln Met Ser Phe Phe
 465                 470                 475                 480
 Val Leu Phe Ala Cys Met Asp Asp Met Leu Leu Ser Val Met Ala Tyr
                 485                 490                 495    
 Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr Arg Ile Ile Met
             500                 505                 510        
 Asn Pro Arg Leu Cys Gly Phe Leu Ile Leu Leu Ser Phe Phe Ile Ser
         515                 520                 525            
 Leu Leu Asp Ser Gln Leu His Asn Leu Ile Met Leu Gln Leu Thr Cys
     530                 535                 540                
 Phe Lys Asp Val Asp Ile Ser Asn Phe Phe Cys Asp Pro Ser Gln Leu
 545                 550                 555                 560
 Leu His Leu Arg Cys Ser Asp Thr Phe Ile Asn Glu Met Val Ile Tyr
                 565                 570                 575    
 Phe Met Gly Ala Ile Phe Gly Cys Leu Pro Ile Ser Gly Ile Leu Phe
             580                 585                 590        
 Ser Tyr Tyr Lys Ile Val Ser Pro Ile Leu Arg Val Pro Thr Ser Asp
         595                 600                 605            
 Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val
     610                 615                 620                
 Cys Leu Phe Tyr Gly Thr Gly Leu Val Gly Tyr Leu Ser Ser Ala Val
 625                 630                 635                 640
 Leu Pro Ser Pro Arg Lys Ser Met Val Ala Ser Val Met Tyr Thr Val
                 645                 650                 655    
 Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp
             660                 665                 670        
 Ile Gln Ser Ala Leu Cys Arg Leu His Gly Arg Ile Ile Lys Ser His
         675                 680                 685            
 His Leu His Pro Phe Cys Tyr Met Gly
     690                 695        



      <210> 957
      <211> 53
      <212> PRT
      <213> Homo sapiens


      <400> 957
 Ile Phe Ile Pro Val Val His Arg Gly Lys Thr Thr Leu Glu Asn Cys
   1               5                  10                  15    
 Val Leu Gln Cys Glu Thr Thr Gly Val Thr Val Arg Thr Ser Ala Glu
              20                  25                  30        
 Phe Leu Met Lys Asn Ser Asp Leu Tyr Gly Ala Lys Val Glu Ala Leu
          35                  40                  45            
 Val Leu Leu Gly Lys
      50            



      <210> 958
      <211> 217
      <212> PRT
      <213> Homo sapiens


      <400> 958
 Ile Gln Cys Gly Gly Ile Pro Leu Leu Pro Leu Pro Ser Pro Leu Ser
   1               5                  10                  15    
 Met Ala His Cys Val Gln Phe Gln Ala Gly Pro Pro Val His Trp Arg
              20                  25                  30        
 Val His Ala Gly Leu Val Ser His Ser Ala Val Arg Pro His Gln Gly
          35                  40                  45            
 Ala Leu Val Glu Arg Ile Ile Pro His Pro Leu Tyr Ser Ala Gln Asn
      50                  55                  60                
 His Asp Tyr Asp Val Ala Leu Leu Arg Leu Gln Thr Ala Leu Asn Phe
  65                  70                  75                  80
 Ser Asp Thr Val Gly Ala Val Cys Leu Pro Ala Lys Glu Gln His Phe
                  85                  90                  95    
 Pro Lys Gly Ser Arg Cys Trp Val Ser Gly Trp Gly His Thr His Pro
             100                 105                 110        
 Ser His Thr Tyr Ser Ser Asp Met Leu Gln Asp Thr Val Val Pro Leu
         115                 120                 125            
 Leu Ser Thr Gln Leu Cys Asn Ser Ser Cys Val Tyr Ser Gly Ala Leu
     130                 135                 140                
 Thr Pro Arg Met Leu Cys Ala Gly Tyr Leu Asp Gly Arg Ala Asp Ala
 145                 150                 155                 160
 Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Pro Asp Gly Asp Thr
                 165                 170                 175    
 Trp Arg Leu Val Gly Val Val Ser Trp Gly Arg Gly Cys Ala Glu Pro
             180                 185                 190        
 Asn His Pro Gly Val Tyr Ala Lys Val Ala Glu Phe Leu Asp Trp Ile
         195                 200                 205            
 His Asp Thr Ala Gln Asp Ser Leu Leu
     210                 215        



      <210> 959
      <211> 250
      <212> PRT
      <213> Homo sapiens


      <400> 959
 Glu Phe Pro Gly Arg Arg Phe Arg Gly Ser Arg Ser Leu Gly Leu Gly
   1               5                  10                  15    
 Ser Gly Thr Arg Thr Lys Pro Pro Ala Ser Ala Met Glu Glu Leu Arg
              20                  25                  30        
 Leu Thr Ser Thr Thr Phe Ala Leu Thr Gly Asp Ser Ala His Asn Gln
          35                  40                  45            
 Val Met Val His Trp Ser Gly His Asn Ser Ser Val Ile Leu Ile Leu
      50                  55                  60                
 Thr Lys Leu Tyr Asp Tyr Asn Leu Gly Ser Ile Thr Glu Ser Ser Leu
  65                  70                  75                  80
 Trp Arg Ser Thr Asp Tyr Gly Thr Thr Tyr Glu Lys Leu Asn Asp Lys
                  85                  90                  95    
 Val Gly Leu Lys Thr Ile Leu Ser Tyr Leu Tyr Val Cys Pro Thr Asn
             100                 105                 110        
 Lys Arg Lys Ile Met Leu Leu Thr Asp Pro Glu Ile Glu Ser Lys Leu
         115                 120                 125            
 Leu Ile Ser Ser Asp Glu Gly Ala Thr Tyr Gln Lys Tyr Arg Val Asn
     130                 135                 140                
 Phe Tyr Ile Gln Ser Leu Leu Phe His Pro Lys Gln Glu Asp Trp Ile
 145                 150                 155                 160
 Leu Ala Tyr Ser Gln Asp Gln Lys Leu Tyr Ser Ser Ala Glu Phe Gly
                 165                 170                 175    
 Arg Arg Trp Gln Leu Ile Gln Glu Gly Val Val Pro Asn Arg Phe Tyr
             180                 185                 190        
 Trp Ser Val Met Gly Ser Asn Lys Glu Pro Asp Leu Val His Leu Glu
         195                 200                 205            
 Ala Arg Thr Val Asp Gly His Ser His Tyr Leu Thr Cys Arg Met Gln
     210                 215                 220                
 Asn Cys Thr Glu Ala Asn Arg Asn Gln Pro Phe Pro Gly Tyr Ile Asp
 225                 230                 235                 240
 Pro Asp Ser Leu Ile Val Gln Asp His Tyr
                 245                 250



      <210> 960
      <211> 275
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(275)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 960
 Gly Arg Val Gly Lys Pro Gly Arg Pro Trp Arg Ile Arg Cys Ala Pro
   1               5                  10                  15    
 Ser Ser Gly Arg Ala Trp Ala Trp Ala His Glu Glu Gly Ala Ala Val
              20                  25                  30        
 Leu Gln Gly Phe Pro Pro Ala Pro Arg Pro Pro Gly Val Val Gly Thr
          35                  40                  45            
 Arg Ser Trp Thr Leu Thr Ser Ala Phe Arg Asp Pro Ser Pro Asp Ala
      50                  55                  60                
 Ala Glu Gly Gln Ser Leu Gly Ser Arg Arg Pro Ala Pro Ser Pro Pro
  65                  70                  75                  80
 Pro Arg Ala Val Gly Pro Gly Arg Xaa Asp Pro Arg Arg Ala Lys Arg
                  85                  90                  95    
 Lys Val Pro Ala Pro Leu Gly Ser Ser Val Ala Gly Ser Gly Gln Val
             100                 105                 110        
 Ser Leu Arg Gly Phe Arg Lys Pro Arg Pro Val Ile Val Ser Gly Asn
         115                 120                 125            
 Pro Ser Trp Ser Phe Pro Lys Ala Met Asp Ser Pro Ser Leu Arg Glu
     130                 135                 140                
 Leu Gln Gln Pro Cys Trp Arg Ala Gln Asn Val Arg Pro Leu Pro Arg
 145                 150                 155                 160
 Ser Leu Ala Gly Met Ser Trp Gly Pro Pro Xaa Glu Arg Xaa Pro Leu
                 165                 170                 175    
 Pro Ser Pro Xaa Gly Val Cys Ser Ser Cys Pro Pro Pro Leu Pro Ser
             180                 185                 190        
 Val Ser Ala Gly Leu Gly Glu Pro Arg Pro Pro Asp Val Glu Asp Met
         195                 200                 205            
 Ser Ser Ser Asp Ser Asp Ser Asp Trp Asp Gly Gly Ser Arg Leu Ser
     210                 215                 220                
 Pro Phe Leu Pro His Asp His Leu Gly Leu Ala Val Phe Ser Met Leu
 225                 230                 235                 240
 Cys Cys Phe Trp Pro Val Gly Ile Ala Ala Phe Cys Leu Ala Gln Lys
                 245                 250                 255    
 His Pro Gln Cys Leu Thr Tyr Ser Arg Cys Tyr Val Ser Ala Phe Gly
             260                 265                 270        
 Ile His Ala
         275



      <210> 961
      <211> 261
      <212> PRT
      <213> Homo sapiens


      <400> 961
 Arg Thr Arg Gly Pro Thr Leu Leu Leu Ile Ile Ile Ile Gly Met Gln
   1               5                  10                  15    
 Leu Ile Thr Ser Leu Gly Leu Gln Glu Phe Asp Ile Ala Arg Asn Val
              20                  25                  30        
 Leu Gln Leu Ile Tyr Ala Gln Thr Leu Gly Trp Ile Gly Ile Phe Phe
          35                  40                  45            
 Cys Pro Leu Leu Pro Phe Ile Gln Met Ile Met Leu Phe Ile Met Val
      50                  55                  60                
 Tyr Ser Lys Asn Ile Ser Leu Met Met Asn Phe Gln Pro Pro Ser Lys
  65                  70                  75                  80
 Ala Trp Arg Ala Ser Gln Met Met Thr Phe Phe Ile Phe Leu Leu Phe
                  85                  90                  95    
 Phe Pro Ser Phe Thr Gly Val Leu Cys Thr Leu Ala Ile Thr Ile Trp
             100                 105                 110        
 Arg Leu Lys Pro Ser Ala Asp Cys Gly Pro Phe Arg Gly Leu Pro Leu
         115                 120                 125            
 Phe Ile His Ser Ile Tyr Ser Trp Ile Asp Thr Leu Ser Thr Arg Pro
     130                 135                 140                
 Gly Tyr Leu Trp Val Val Trp Ile Tyr Arg Asn Leu Ile Gly Ser Val
 145                 150                 155                 160
 His Phe Phe Phe Ile Leu Thr Leu Ile Val Leu Ile Ile Thr Tyr Leu
                 165                 170                 175    
 Tyr Trp Gln Ile Thr Glu Gly Arg Lys Ile Met Ile Arg Leu Leu His
             180                 185                 190        
 Glu Gln Ile Ile Asn Glu Gly Lys Asp Lys Met Phe Leu Ile Glu Lys
         195                 200                 205            
 Leu Ile Lys Leu Gln Asp Met Glu Lys Lys Ala Asn Pro Ser Ser Leu
     210                 215                 220                
 Val Leu Glu Arg Arg Glu Val Glu Gln Gln Gly Phe Leu His Leu Gly
 225                 230                 235                 240
 Glu His Asp Gly Ser Leu Asp Leu Arg Ser Arg Arg Ser Val Gln Glu
                 245                 250                 255    
 Gly Asn Pro Arg Ala
             260    



      <210> 962
      <211> 254
      <212> PRT
      <213> Homo sapiens


      <400> 962
 Pro Met Ser Ser Pro Val Arg Glu Pro Pro Gln Leu Glu Glu Glu Arg
   1               5                  10                  15    
 Gln Val Arg Ile Ser Glu Ser Gly Gln Phe Ser Asp Gly Leu Glu Asp
              20                  25                  30        
 Arg Gly Leu Leu Glu Ser Ser Thr Arg Leu Lys Pro His Glu Ala Gln
          35                  40                  45            
 Asn Tyr Arg Lys Lys Ala Leu Trp Val Ser Trp Phe Ser Ile Ile Val
      50                  55                  60                
 Thr Leu Ala Leu Ala Val Ala Ala Phe Thr Val Ser Val Met Arg Tyr
  65                  70                  75                  80
 Ser Ala Ser Ala Phe Gly Phe Ala Phe Asp Ala Ile Leu Asp Val Leu
                  85                  90                  95    
 Ser Ser Ala Ile Val Leu Trp Arg Tyr Ser Asn Ala Ala Ala Val His
             100                 105                 110        
 Ser Ala His Arg Glu Tyr Met Leu Tyr Asn His Gly Thr Asn Ile Cys
         115                 120                 125            
 Trp Thr Ser Ser Glu Gly Leu Arg Met Leu Thr Ile Met Val Glu Asp
     130                 135                 140                
 Asp Ser Leu Leu Phe His Ser Pro Val Val Gly His Leu Gly Tyr Phe
 145                 150                 155                 160
 Gln Phe Leu Thr Ile Met Lys Leu Ala Ala Glu Asn Thr Gly Val Gln
                 165                 170                 175    
 Val Phe Val Trp Thr Tyr Ala Phe Ile Ser Leu Gly Val Glu Leu Leu
             180                 185                 190        
 Asn Pro Met Val Ala Pro Lys His Ile Cys Gln Val Glu Tyr His Gly
         195                 200                 205            
 Glu Ala Ser Ala Leu Ser Ile Ile Thr Gly Ala Pro Pro Asp Leu Ala
     210                 215                 220                
 Glu Asn Ser Leu Cys Leu Gly Leu Gly Arg Arg Ala Glu Val Gln Arg
 225                 230                 235                 240
 Lys Pro Cys Pro Val Leu Ser Gly Ser Ala Pro Glu Phe His
                 245                 250                



      <210> 963
      <211> 557
      <212> PRT
      <213> Homo sapiens


      <400> 963
 Ile Leu His His Asn Lys Gln Pro Thr Pro Met Ala Tyr Leu Asp Lys
   1               5                  10                  15    
 Leu Asp Leu Thr Asp Asn His Leu Thr Thr Leu Pro Leu Ala Gly Leu
              20                  25                  30        
 Gly Gly Leu Met His Leu Lys Leu Lys Gly Asn Leu Ala Leu Ser Gln
          35                  40                  45            
 Ala Phe Ser Lys Asp Ser Phe Pro Lys Leu Arg Ile Leu Glu Val Pro
      50                  55                  60                
 Tyr Ala Tyr Gln Cys Cys Pro Tyr Gly Met Cys Ala Ser Phe Phe Lys
  65                  70                  75                  80
 Ala Ser Gly Gln Trp Glu Ala Glu Asp Leu His Leu Asp Asp Glu Glu
                  85                  90                  95    
 Ser Ser Lys Arg Pro Leu Gly Leu Leu Ala Arg Gln Ala Glu Asn His
             100                 105                 110        
 Tyr Asp Gln Asp Leu Asp Glu Leu Gln Leu Glu Met Glu Asp Ser Lys
         115                 120                 125            
 Pro His Pro Ser Val Gln Cys Ser Pro Thr Pro Gly Pro Phe Lys Pro
     130                 135                 140                
 Cys Glu Tyr Leu Phe Glu Ser Trp Gly Ile Arg Leu Ala Val Trp Ala
 145                 150                 155                 160
 Ile Val Leu Leu Ser Val Leu Cys Asn Gly Leu Val Leu Leu Thr Val
                 165                 170                 175    
 Phe Ala Gly Gly Pro Ala Pro Leu Pro Pro Val Lys Phe Val Val Gly
             180                 185                 190        
 Ala Ile Ala Gly Ala Asn Thr Leu Thr Gly Ile Ser Cys Gly Leu Leu
         195                 200                 205            
 Ala Ser Val Asp Ala Leu Thr Phe Gly Gln Phe Ser Glu Tyr Gly Ala
     210                 215                 220                
 Arg Trp Glu Thr Gly Leu Gly Cys Arg Ala Thr Gly Phe Leu Ala Val
 225                 230                 235                 240
 Leu Gly Ser Glu Ala Ser Val Leu Leu Leu Thr Leu Ala Ala Val Gln
                 245                 250                 255    
 Cys Ser Val Ser Val Ser Cys Val Arg Ala Tyr Gly Lys Ser Pro Ser
             260                 265                 270        
 Leu Gly Ser Val Arg Ala Gly Val Leu Gly Cys Leu Ala Leu Ala Gly
         275                 280                 285            
 Leu Ala Ala Ala Leu Pro Leu Ala Ser Val Gly Glu Tyr Gly Ala Ser
     290                 295                 300                
 Pro Leu Cys Leu Pro Tyr Ala Pro Pro Glu Gly Gln Pro Ala Ala Leu
 305                 310                 315                 320
 Gly Phe Thr Val Ala Leu Val Met Met Asn Ser Phe Cys Phe Leu Val
                 325                 330                 335    
 Val Ala Gly Ala Tyr Ile Lys Leu Tyr Cys Asp Leu Pro Arg Gly Asp
             340                 345                 350        
 Phe Glu Ala Val Trp Asp Cys Ala Met Val Arg His Val Ala Trp Leu
         355                 360                 365            
 Ile Phe Ala Asp Gly Leu Leu Tyr Cys Pro Val Ala Phe Leu Ser Phe
     370                 375                 380                
 Ala Ser Met Leu Gly Leu Phe Pro Val Thr Pro Glu Ala Val Lys Ser
 385                 390                 395                 400
 Val Leu Leu Val Val Leu Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu
                 405                 410                 415    
 Tyr Leu Leu Phe Asn Pro His Phe Arg Asp Asp Leu Arg Arg Leu Arg
             420                 425                 430        
 Pro Arg Ala Gly Asp Ser Gly Pro Leu Ala Tyr Ala Ala Ala Gly Glu
         435                 440                 445            
 Leu Glu Lys Ser Ser Cys Asp Ser Thr Gln Ala Leu Val Ala Phe Ser
     450                 455                 460                
 Asp Val Asp Leu Ile Leu Glu Ala Ser Glu Ala Gly Arg Pro Pro Gly
 465                 470                 475                 480
 Leu Glu Thr Tyr Gly Phe Pro Ser Val Thr Leu Ile Ser Cys Gln Gln
                 485                 490                 495    
 Pro Gly Ala Pro Arg Leu Glu Gly Ser His Cys Val Glu Pro Glu Gly
             500                 505                 510        
 Asn His Phe Gly Asn Pro Gln Pro Ser Met Asp Gly Glu Leu Leu Leu
         515                 520                 525            
 Arg Ala Glu Gly Ser Thr Pro Ala Gly Gly Gly Leu Ser Gly Gly Gly
     530                 535                 540                
 Gly Phe Gln Pro Ser Gly Leu Ala Phe Ala Ser His Val
 545                 550                 555        



      <210> 964
      <211> 115
      <212> PRT
      <213> Homo sapiens


      <400> 964
 Met Gly Cys Trp Gly Leu Val Ile Tyr Ala Ala Thr Gly Ala Ile Cys
   1               5                  10                  15    
 Ser Ala Leu Leu Gln Lys Tyr Leu Asp Asn Tyr Asp Leu Ser Val Arg
              20                  25                  30        
 Val Ile Tyr Val Leu Gly Thr Leu Gly Phe Ser Val Gly Thr Ala Val
          35                  40                  45            
 Met Ala Met Phe Pro Asn Val Tyr Val Ala Met Val Thr Ile Ser Thr
      50                  55                  60                
 Met Gly Ile Val Ser Met Ser Ile Ser Tyr Cys Pro Tyr Ala Leu Leu
  65                  70                  75                  80
 Gly Gln Tyr His Asp Ile Lys Gln Tyr Ile His His Ser Pro Gly Asn
                  85                  90                  95    
 Ser Lys Arg Gly Phe Gly Ile Asp Cys Ala Ile Leu Ser Cys Gln Val
             100                 105                 110        
 Tyr Ile Ser
         115



      <210> 965
      <211> 64
      <212> PRT
      <213> Homo sapiens


      <400> 965
 Tyr Ile Phe Thr Ile Leu Asn Thr Leu Gln Gly Val Phe Ile Leu Leu
   1               5                  10                  15    
 Phe Gly Cys Leu Met Asp Arg Lys Ile Gln Glu Ala Leu Arg Lys Arg
              20                  25                  30        
 Phe Cys Arg Ala Gln Ala Pro Ser Ser Thr Ile Ser Leu Ala Thr Asn
          35                  40                  45            
 Glu Gly Cys Ile Leu Glu His Ser Lys Gly Gly Ser Asp Thr Ala Arg
      50                  55                  60                





      <210> 966
      <211> 140
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(140)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 966
 Arg Val Gly His His Pro Pro Ser Val Arg His Pro His Gln Gly His
   1               5                  10                  15    
 Pro Gly Trp Leu Arg Asp Pro Val Gln Leu His Leu Trp Ser Ser Cys
              20                  25                  30        
 Val Ala Phe Pro Pro Gly Gly Ala Pro Ala Gly Leu Pro Pro Ser Asp
          35                  40                  45            
 Gln Asp Pro Gly Pro Pro Leu Ala Ile Ser Pro Thr His Trp Pro Pro
      50                  55                  60                
 Pro Cys Gly Gln Pro Cys Lys Thr Ile Ala Ala His Gly Asn Gly His
  65                  70                  75                  80
 Thr Arg Thr Gly Gly Arg Xaa Arg Pro Arg Arg Leu Xaa Ser Arg Pro
                  85                  90                  95    
 Ala Glu Trp Pro Ser Ala Pro Lys Gly Arg Ser Gly Gly Leu Pro Gly
             100                 105                 110        
 Ser Phe Gln Glu Pro Ala Asp Ser Tyr Pro Gly Cys Gly Thr Trp Cys
         115                 120                 125            
 Ser Ser Ala Cys Lys Gly Arg Gln Pro Ser Tyr Ser
     130                 135                 140



      <210> 967
      <211> 259
      <212> PRT
      <213> Homo sapiens


      <400> 967
 Gly Ser Phe Phe Phe Phe Phe Lys Tyr Phe Ala Tyr Ser Pro Met Pro
   1               5                  10                  15    
 Lys Asn Ser Lys Val Val Lys Arg Glu Leu Asp Asp Asp Val Thr Glu
              20                  25                  30        
 Ser Val Lys Asp Leu Leu Ser Asn Glu Asp Ala Ala Asp Asp Ala Phe
          35                  40                  45            
 Lys Thr Ser Glu Leu Ile Val Asp Gly Gln Glu Glu Lys Asp Thr Asp
      50                  55                  60                
 Val Glu Gly Lys Ser Glu Val Glu Asp Glu Arg Pro Ala Trp Asn Ser
  65                  70                  75                  80
 Lys Leu Gln Tyr Ile Leu Ala Gln Val Gly Phe Ser Val Gly Leu Gly
                  85                  90                  95    
 Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Lys Asn Gly Gly Val Val
             100                 105                 110        
 Glu Pro Glu Cys Glu Gln Ser Ser Ala Thr Thr Tyr Tyr Trp Tyr Arg
         115                 120                 125            
 Glu Ala Leu Asn Ile Ser Ser Ser Ile Ser Glu Ser Gly Gly Leu Asn
     130                 135                 140                
 Trp Lys Met Thr Ile Cys Leu Leu Ala Ala Trp Val Met Val Cys Leu
 145                 150                 155                 160
 Ala Met Ile Lys Gly Ile Gln Ser Ser Gly Lys Val Asn Thr Tyr Asp
                 165                 170                 175    
 Arg Val Thr Met Ser Ala Thr Val Leu Ala Leu Gln Glu Gln Trp Gln
             180                 185                 190        
 Thr Phe Ser Pro Ile Arg Ser Gly Asn Gly His Leu Thr Gly Ser Gly
         195                 200                 205            
 Ala Gln Arg Thr Pro Cys Arg Ile Arg Arg Gly Gly Ser Gln Leu Arg
     210                 215                 220                
 Val Cys Asp Gly Gly Lys Gln Gln Trp Trp Thr Val Ser Gln Ser Ser
 225                 230                 235                 240
 Ala Arg Ala Ile Thr Asn Thr Asp Gln Lys Ser Val Gln Leu Gln Asp
                 245                 250                 255    
 Leu Ile Glu
            



      <210> 968
      <211> 432
      <212> PRT
      <213> Homo sapiens


      <400> 968
 Ala Val Pro Gly Thr Lys Gly Glu Lys Cys Pro Gly Leu Trp Glu Lys
   1               5                  10                  15    
 His Phe Pro Thr Leu Ile Leu Gly Ser His Arg Val Val Thr Asn Gly
              20                  25                  30        
 Val Pro Gly Phe Gln Ser Trp Leu Tyr Phe Ser Lys Pro Cys Asp Arg
          35                  40                  45            
 Gly His Val Ala Glu Pro Leu Trp Ala Leu Ala Phe Thr Asn Thr Tyr
      50                  55                  60                
 Leu Phe Tyr Gly Ala Tyr Arg Val Gly Pro Glu Ser Ser Ser Val Tyr
  65                  70                  75                  80
 Ser Ile Arg Leu Ala Tyr Leu Leu Ser Pro Leu Ala Cys Leu Leu Leu
                  85                  90                  95    
 Cys Phe Cys Gly Thr Leu Arg Arg Met Val Lys Gly Leu Pro Gln Lys
             100                 105                 110        
 Thr Leu Leu Gly Gln Gly Tyr Gln Ala Pro Leu Ser Ala Lys Val Phe
         115                 120                 125            
 Ser Ser Trp Asp Phe Cys Ile Arg Val Gln Glu Ala Ala Thr Ile Lys
     130                 135                 140                
 Lys His Glu Ile Ser Asn Glu Phe Lys Val Glu Leu Glu Glu Gly Arg
 145                 150                 155                 160
 Arg Phe Gln Leu Met Gln Gln Gln Thr Arg Ala Gln Thr Ala Cys Arg
                 165                 170                 175    
 Leu Leu Ser Tyr Leu Arg Val Asn Val Leu Ile Gly Leu Leu Val Val
             180                 185                 190        
 Gly Ala Ile Ser Ala Ile Phe Trp Ala Thr Lys Tyr Ser Gln Asp Asn
         195                 200                 205            
 Lys Glu Glu Ser Leu Phe Leu Leu Leu Gln Tyr Leu Pro Pro Gly Val
     210                 215                 220                
 Ile Ala Leu Val Asn Phe Leu Gly Pro Leu Leu Phe Thr Phe Leu Val
 225                 230                 235                 240
 Gln Leu Glu Asn Tyr Pro Pro Asn Thr Glu Val Asn Leu Thr Leu Ile
                 245                 250                 255    
 Trp Cys Val Val Leu Lys Leu Ala Ser Leu Gly Met Phe Ser Val Ser
             260                 265                 270        
 Leu Gly Gln Thr Ile Leu Cys Ile Gly Arg Asp Lys Ser Ser Cys Glu
         275                 280                 285            
 Ser Tyr Gly Tyr Asn Val Cys Asp Tyr Gln Cys Trp Glu Asn Ser Val
     290                 295                 300                
 Gly Glu Glu Leu Tyr Lys Leu Ser Ile Phe Asn Phe Leu Leu Thr Val
 305                 310                 315                 320
 Ala Phe Ala Phe Leu Val Thr Leu Pro Arg Arg Leu Leu Val Asp Arg
                 325                 330                 335    
 Phe Ser Gly Arg Phe Trp Ala Trp Leu Glu Arg Glu Glu Phe Leu Val
             340                 345                 350        
 Pro Lys Asn Val Leu Asp Ile Val Ala Gly Gln Thr Val Thr Trp Met
         355                 360                 365            
 Gly Leu Phe Tyr Cys Pro Leu Leu Pro Leu Leu Asn Ser Val Phe Leu
     370                 375                 380                
 Phe Leu Thr Phe Tyr Ile Lys Lys Val Thr Ala His Gly Trp Gly Val
 385                 390                 395                 400
 Trp Gly Ser Cys Leu Trp Val Asp Ala Leu Ser Trp Ala Arg Leu Leu
                 405                 410                 415    
 Leu Leu Leu Leu Pro Pro Ser Leu Gly Val Ser Pro Leu Gly Ser Ala
             420                 425                 430        





      <210> 969
      <211> 205
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(205)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 969
 His Gly Asp Glu Asn Ser Glu Val Trp Arg Ser Leu Phe Ala Arg Ser
   1               5                  10                  15    
 Leu Ala Glu Glu Ala Leu Arg Thr Asp Ile Leu Cys Asn Leu Pro Ser
              20                  25                  30        
 Tyr Lys Ala Lys Ile Arg Ala Phe Gln His Ala Phe Ser Thr Asn Asp
          35                  40                  45            
 Cys Ser Arg Asn Val Tyr Ile Lys Lys Asn Gly Phe Thr Leu His Arg
      50                  55                  60                
 Asn Pro Ile Ala Gln Ser Thr Asp Gly Ala Arg Thr Lys Ile Gly Phe
  65                  70                  75                  80
 Ser Glu Gly Arg His Ala Trp Glu Val Trp Trp Glu Gly Pro Leu Gly
                  85                  90                  95    
 Thr Val Ala Val Ile Gly Ile Ala Thr Lys Arg Ala Pro Met Gln Cys
             100                 105                 110        
 Gln Gly Tyr Val Ala Leu Leu Gly Ser Asp Asp Gln Ser Trp Gly Trp
         115                 120                 125            
 Asn Leu Val Asp Asn Asn Leu Leu His Asn Gly Glu Val Asn Gly Ser
     130                 135                 140                
 Phe Pro Gln Cys Asn Asn Ala Pro Lys Tyr Gln Ile Gly Glu Arg Ile
 145                 150                 155                 160
 Arg Val Ile Leu Asp Met Glu Asp Lys Thr Leu Ala Phe Glu Arg Gly
                 165                 170                 175    
 Tyr Glu Phe Leu Gly Val Ala Phe Xaa Arg Ile Ser Lys Gly Leu Leu
             180                 185                 190        
 Tyr Asn Pro Ala Val Ser Ala Val Tyr Gly Asn Thr Glu
         195                 200                 205



      <210> 970
      <211> 988
      <212> PRT
      <213> Homo sapiens


      <400> 970
 Met Gly Glu Asp Phe Met Thr Lys Thr Pro Lys Ala Met Ala Thr Lys
   1               5                  10                  15    
 Ala Lys Ile Asp Lys Trp His Leu Ile Lys Leu Lys Ser Phe Cys Thr
              20                  25                  30        
 Ala Lys Glu Thr Thr Ile Arg Met Asn Arg Gln Pro Thr Glu Trp Glu
          35                  40                  45            
 Lys Ile Phe Ala Ile Tyr Pro Ser Asp Lys Gly Leu Ile Ser Arg Ile
      50                  55                  60                
 Cys Lys Glu Leu Lys Gln Ile Tyr Lys Lys Lys Ser Asn Asn Ser Ile
  65                  70                  75                  80
 Asn Lys Trp Ala Lys Asp Met Asn Arg His Phe Ser Lys Glu Asp Ile
                  85                  90                  95    
 Tyr Ala Thr Lys Arg His Met Lys Glu Cys Ser Ser Ser Leu Ala Ile
             100                 105                 110        
 Arg Glu Met Gln Ile Lys Thr Thr Met Arg Tyr Tyr Leu Thr Pro Val
         115                 120                 125            
 Arg Met Ala Ile Ile Lys Lys Ser Gly Asn Asn Arg Cys Trp Lys Gly
     130                 135                 140                
 Tyr Gly Glu Ile Gly Thr Leu Leu His Cys Trp Trp Asp Cys Lys Leu
 145                 150                 155                 160
 Val Gln Pro Leu Trp Lys Thr Val Trp Arg Phe Leu Lys Asp Leu Glu
                 165                 170                 175    
 Leu Glu Ile Pro Phe Asp Pro Ala Ile Pro Leu Leu Gly Ile Tyr Pro
             180                 185                 190        
 Lys Asp Tyr Lys Ser Cys Cys Tyr Lys Asp Thr Cys Thr Arg Ser Ile
         195                 200                 205            
 Leu Tyr Ala Gln Ser Phe Leu Gly Thr Ser His Leu Asn Gly Gln Phe
     210                 215                 220                
 Leu Cys Leu Thr Arg Lys Val Val Gly Gly Phe Arg Thr Cys Gln Lys
 225                 230                 235                 240
 Gln Ser Glu Gly Leu Gln Thr Leu Arg Thr Asp Gly Leu Arg His Ser
                 245                 250                 255    
 Trp Asp Cys Leu Tyr Thr Ala Met Glu Ser Asp Ser Gly Gly His Arg
             260                 265                 270        
 Lys Val Trp Lys Pro Gly Tyr Cys Val Val Arg Phe Arg Arg Asp Ala
         275                 280                 285            
 Lys Ala Leu Lys Ser Val Arg Glu Ala Ala Pro Ala Ala Gly Asp Ser
     290                 295                 300                
 Arg Gln Arg Gly Arg Ser Tyr Gly Ala Arg Ala Leu Asp Ala Pro Ala
 305                 310                 315                 320
 Arg Glu His Ala Glu Trp Thr Lys Cys Ile Val Gln Leu Gly His Leu
                 325                 330                 335    
 Leu Ala Thr Gln His Pro Ala Ala Pro Thr Cys Gly Val Val Ser Ser
             340                 345                 350        
 Ala Leu Val Met His Ser Thr Asp Val Cys Leu Ala Pro Thr Met His
         355                 360                 365            
 Gln Ala Leu Asp Trp Ala Ala Gly Ile Trp Phe Thr Gly Arg Leu Gly
     370                 375                 380                
 Leu Arg Glu His Lys Ser Leu Ala Gln Gly Asp Ser Val Cys Pro Cys
 385                 390                 395                 400
 Glu Ser Glu Leu Gly Asp Phe Gln Val Tyr Gly Leu Val Ser Thr Glu
                 405                 410                 415    
 Gly Val Val Ser Cys Phe Gly Glu Lys Thr Pro Gln His Pro Gly Pro
             420                 425                 430        
 Pro Ala Ser Leu Ser Leu Ala Asn Arg Cys His Asn Val Val Thr Ala
         435                 440                 445            
 Val Gly Ala Trp Pro Ala His Gly Ser Ile Leu Gly Asn Val Pro Glu
     450                 455                 460                
 Ala Pro Val Gly Ala Asp Val Leu Gly Ala Gly Gly Cys Asp Trp Ala
 465                 470                 475                 480
 Asp Lys Glu Ala Leu Ala Pro Gly Gln Arg Ala Lys Val His Ile Leu
                 485                 490                 495    
 Leu Glu Ser Ser Gly Gln Ser Asp Pro Ser Tyr Ala Val Leu Pro Asp
             500                 505                 510        
 Ser Trp Ala Ala Thr Glu Gly Phe Pro Thr Tyr Arg Ser Gln Val Ser
         515                 520                 525            
 Ser Pro Arg Ile Pro Gly Ser Ser Ile Trp Leu Gly Ser Gly Ser Gly
     530                 535                 540                
 Trp Pro Ile Leu Gly Glu Leu Arg Glu Cys Asp Gln Met Phe Ser Cys
 545                 550                 555                 560
 Met Leu Pro Thr Gly Cys Ala Ser Phe Gln Asp Pro Gly Arg Tyr Gly
                 565                 570                 575    
 Asp Tyr Asp Leu Pro Met Asp Glu Asp Glu Asp Met Thr Lys Thr Arg
             580                 585                 590        
 Thr Phe Phe Ala Ala Lys Ile Val Ile Gly Ile Ala Leu Ala Gly Ile
         595                 600                 605            
 Met Leu Val Cys Gly Ile Gly Asn Phe Val Phe Ile Ala Ala Leu Thr
     610                 615                 620                
 Arg Tyr Lys Lys Leu Arg Asn Leu Thr Asn Leu Leu Ile Ala Asn Leu
 625                 630                 635                 640
 Ala Ile Ser Asp Phe Leu Val Ala Ile Ile Cys Cys Pro Phe Glu Met
                 645                 650                 655    
 Asp Tyr Tyr Val Val Arg Gln Leu Ser Trp Glu His Gly His Val Leu
             660                 665                 670        
 Cys Ala Ser Val Asn Tyr Leu Arg Thr Val Ser Leu Tyr Val Ser Thr
         675                 680                 685            
 Asn Ala Leu Leu Ala Ile Ala Ile Asp Arg Phe Ser Ser Thr Ile Tyr
     690                 695                 700                
 Asp Ser Phe Leu Ile Cys Pro Gln Val Gly Gly Cys Val Gln Arg Val
 705                 710                 715                 720
 Leu Leu Val Thr Val Gly Val Leu Leu Ser Ile Ser Leu Asp Met Thr
                 725                 730                 735    
 Ala Asn Gly Gly Ser Ser Gly Ser Ser Trp Asn Leu Phe Leu Ser Ile
             740                 745                 750        
 Trp Leu Met Ile Arg Tyr Leu Ala Ile Val His Pro Leu Lys Pro Arg
         755                 760                 765            
 Met Asn Tyr Gln Thr Ala Ser Phe Leu Ile Ala Leu Val Trp Met Val
     770                 775                 780                
 Ser Ile Leu Ile Ala Ile Pro Ser Ala Tyr Phe Ala Thr Glu Thr Val
 785                 790                 795                 800
 Leu Phe Ile Val Lys Ser Gln Glu Lys Ile Phe Cys Gly Gln Ile Trp
                 805                 810                 815    
 Pro Val Asp Gln Gln Leu Tyr Tyr Lys Ser Tyr Phe Leu Phe Ile Phe
             820                 825                 830        
 Gly Val Glu Phe Val Gly Pro Val Val Thr Met Thr Leu Cys Tyr Ala
         835                 840                 845            
 Arg Ile Ser Arg Glu Leu Trp Phe Lys Ala Val Pro Gly Phe Gln Thr
     850                 855                 860                
 Glu Gln Ile Arg Lys Arg Leu Arg Cys Arg Arg Lys Thr Val Leu Val
 865                 870                 875                 880
 Leu Met Cys Ile Leu Thr Ala Tyr Val Leu Cys Trp Ala Pro Phe Tyr
                 885                 890                 895    
 Gly Phe Thr Ile Val Arg Asp Phe Phe Pro Thr Val Phe Val Lys Glu
             900                 905                 910        
 Lys His Tyr Leu Thr Ala Phe Tyr Val Val Glu Cys Ile Ala Met Ser
         915                 920                 925            
 Asn Ser Met Ile Asn Thr Val Cys Phe Val Thr Val Lys Asn Asn Thr
     930                 935                 940                
 Met Lys Tyr Phe Lys Lys Met Met Leu Leu His Trp Arg Pro Ser Gln
 945                 950                 955                 960
 Arg Gly Ser Lys Ser Ser Ala Asp Leu Asp Leu Arg Thr Asn Gly Val
                 965                 970                 975    
 Pro Thr Thr Glu Glu Val Asp Cys Ile Arg Leu Lys
             980                 985            



      <210> 971
      <211> 151
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(151)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 971
 Xaa Pro Gly Cys Pro Thr Gly Tyr Leu Gly Pro Gly Gly Ile Gly Asp
   1               5                  10                  15    
 Phe Gly Lys Tyr Pro Asn Cys Thr Gly Gly Ala Ala Gly Tyr Ile Asp
              20                  25                  30        
 Arg Leu Leu Leu Gly Asp Asp His Leu Tyr Gln His Pro Ser Ser Ala
          35                  40                  45            
 Val Leu Tyr His Thr Glu Val Ala Tyr Asp Pro Glu Gly Ile Leu Gly
      50                  55                  60                
 Thr Ile Asn Ser Ile Val Met Ala Phe Leu Gly Val Gln Ala Gly Lys
  65                  70                  75                  80
 Ile Leu Leu Tyr Tyr Lys Ala Arg Thr Lys Asp Ile Leu Ile Arg Phe
                  85                  90                  95    
 Thr Ala Trp Cys Cys Ile Leu Gly Leu Ile Ser Val Ala Leu Thr Lys
             100                 105                 110        
 Val Ser Glu Asn Glu Gly Phe Ile Pro Val Asn Lys Asn Leu Trp Ser
         115                 120                 125            
 Leu Ser Tyr Val Thr Thr Leu Ser Ser Phe Ala Phe Phe Ile Leu Leu
     130                 135                 140                
 Val Leu Tyr Gln Leu Trp Met
 145                 150    



      <210> 972
      <211> 203
      <212> PRT
      <213> Homo sapiens


      <400> 972
 Arg Cys Ala Val Leu Phe Cys Ser Ser Cys Ser Lys Val Ile Gln Val
   1               5                  10                  15    
 Gly Gln Val His Gly Gly Leu Met Gly Ile Ile Gln Arg Ala Met Val
              20                  25                  30        
 Lys Ala Cys Pro His Val Trp Phe Glu Arg Ser Glu Met Lys Asp Arg
          35                  40                  45            
 His Leu Val Thr Lys Arg Leu Lys Glu His Ile Ala Asp Lys Lys Lys
      50                  55                  60                
 Leu Pro Ile Leu Ile Phe Pro Glu Gly Thr Cys Ile Asn Asn Thr Ser
  65                  70                  75                  80
 Val Met Met Phe Lys Lys Gly Ser Phe Glu Ile Gly Gly Thr Ile His
                  85                  90                  95    
 Pro Val Ala Ile Lys Tyr Asn Pro Gln Phe Gly Asp Ala Phe Trp Asn
             100                 105                 110        
 Ser Ser Lys Tyr Asn Met Val Ser Tyr Leu Leu Arg Met Met Thr Ser
         115                 120                 125            
 Trp Ala Ile Val Cys Asp Val Trp Tyr Met Pro Pro Met Thr Arg Glu
     130                 135                 140                
 Glu Gly Glu Asp Ala Val Gln Phe Ala Asn Arg Val Lys Ser Ala Ile
 145                 150                 155                 160
 Ala Ile Gln Gly Gly Leu Thr Glu Leu Pro Trp Asp Gly Gly Leu Lys
                 165                 170                 175    
 Arg Ala Lys Val Lys Asp Ile Phe Lys Glu Glu Gln Gln Lys Asn Tyr
             180                 185                 190        
 Ser Lys Met Ile Val Gly Asn Gly Ser Leu Ser
         195                 200            



      <210> 973
      <211> 333
      <212> PRT
      <213> Homo sapiens


      <400> 973
 Ala Trp His Glu Gly Leu Val Ser Ser Pro Ala Ile Gly Ala Tyr Leu
   1               5                  10                  15    
 Ser Ala Ser Tyr Gly Asp Ser Leu Val Val Leu Val Ala Thr Val Val
              20                  25                  30        
 Ala Leu Leu Asp Ile Cys Phe Ile Leu Val Ala Val Pro Glu Ser Leu
          35                  40                  45            
 Pro Glu Lys Met Arg Pro Val Ser Trp Gly Ala Gln Ile Ser Trp Lys
      50                  55                  60                
 Gln Ala Asp Pro Phe Ala Ser Leu Lys Lys Val Gly Lys Asp Ser Thr
  65                  70                  75                  80
 Val Leu Leu Ile Cys Ile Thr Val Cys Leu Ser Tyr Leu Pro Glu Ala
                  85                  90                  95    
 Gly Gln Tyr Ser Ser Phe Phe Leu Tyr Leu Arg Gln Val Ile Gly Phe
             100                 105                 110        
 Gly Thr Val Lys Ile Ala Ala Phe Ile Ala Met Val Gly Ile Leu Ser
         115                 120                 125            
 Ile Val Ala Gln Thr Ala Phe Leu Ser Ile Leu Met Arg Ser Leu Gly
     130                 135                 140                
 Asn Lys Asn Thr Val Leu Leu Gly Leu Gly Phe Gln Met Leu Gln Leu
 145                 150                 155                 160
 Ala Trp Tyr Gly Phe Gly Ser Gln Ala Trp Met Met Trp Ala Ala Gly
                 165                 170                 175    
 Thr Val Ala Ala Met Ser Ser Ile Thr Phe Pro Ala Ile Ser Ala Leu
             180                 185                 190        
 Val Ser Arg Asn Ala Glu Ser Asp Gln Gln Gly Val Ala Gln Gly Ile
         195                 200                 205            
 Ile Thr Gly Ile Arg Gly Leu Cys Asn Gly Leu Gly Pro Ala Leu Tyr
     210                 215                 220                
 Gly Phe Ile Phe Tyr Met Phe His Val Glu Leu Thr Glu Leu Gly Pro
 225                 230                 235                 240
 Lys Leu Asn Ser Asn Asn Val Pro Leu Gln Gly Ala Val Ile Pro Gly
                 245                 250                 255    
 Pro Pro Phe Leu Phe Gly Ala Cys Ile Val Leu Met Ser Phe Leu Ala
             260                 265                 270        
 Ala Leu Phe Ile Pro Glu Tyr Ser Lys Ala Ser Gly Val Gln Lys His
         275                 280                 285            
 Ser Asn Ser Ser Ser Gly Ser Leu Thr Asn Thr Pro Glu Arg Gly Ser
     290                 295                 300                
 Asp Glu Asp Ile Glu Pro Leu Leu Gln Asp Ser Ser Ile Trp Glu Leu
 305                 310                 315                 320
 Ser Ser Phe Glu Glu Pro Gly Asn Gln Cys Thr Glu Leu
                 325                 330            



      <210> 974
      <211> 129
      <212> PRT
      <213> Homo sapiens


      <400> 974
 Ala Ala Gly Asp Ala Pro Leu Arg Ser Leu Glu Gln Ala Asn Arg Thr
   1               5                  10                  15    
 Arg Phe Pro Phe Phe Ser Asp Val Lys Gly Asp His Arg Leu Val Leu
              20                  25                  30        
 Ala Ala Val Glu Thr Thr Val Leu Val Leu Ile Phe Ala Val Ser Leu
          35                  40                  45            
 Leu Gly Asn Val Cys Ala Leu Val Leu Val Ala Arg Arg Arg Arg Arg
      50                  55                  60                
 Gly Ala Thr Ala Cys Leu Val Leu Asn Leu Phe Cys Ala Asp Leu Leu
  65                  70                  75                  80
 Phe Ile Ser Ala Ile Pro Leu Val Leu Ala Val Arg Trp Thr Glu Ala
                  85                  90                  95    
 Trp Leu Leu Gly Pro Val Ala Cys His Leu Leu Phe Tyr Val Met Thr
             100                 105                 110        
 Leu Ser Gly Ser Val Thr Ile Leu Thr Leu Ala Ala Val Ser Leu Glu
         115                 120                 125            
 Arg
    



      <210> 975
      <211> 252
      <212> PRT
      <213> Homo sapiens


      <400> 975
 Met Gly Cys Ala Ile Ile Ala Gly Phe Leu His Tyr Leu Phe Leu Ala
   1               5                  10                  15    
 Cys Phe Phe Trp Met Leu Val Glu Ala Val Ile Leu Phe Leu Met Val
              20                  25                  30        
 Arg Asn Leu Lys Val Val Asn Tyr Phe Ser Ser Arg Asn Ile Lys Met
          35                  40                  45            
 Leu His Ile Cys Ala Phe Gly Tyr Gly Leu Pro Met Leu Val Val Val
      50                  55                  60                
 Ile Ser Ala Ser Val Gln Pro Gln Gly Tyr Gly Met His Asn Arg Cys
  65                  70                  75                  80
 Trp Leu Asn Thr Glu Thr Gly Phe Ile Trp Ser Phe Leu Gly Pro Val
                  85                  90                  95    
 Cys Thr Val Ile Val Ile Asn Ser Leu Leu Leu Thr Trp Thr Leu Trp
             100                 105                 110        
 Ile Leu Arg Gln Arg Leu Ser Ser Val Asn Ala Glu Val Ser Thr Leu
         115                 120                 125            
 Lys Asp Thr Arg Leu Leu Thr Phe Lys Ala Phe Ala Gln Leu Phe Ile
     130                 135                 140                
 Leu Gly Cys Ser Trp Val Leu Gly Ile Phe Gln Ile Gly Pro Val Ala
 145                 150                 155                 160
 Gly Val Met Ala Tyr Leu Phe His His His Gln Gln Pro Ala Gly Gly
                 165                 170                 175    
 Leu His Leu Pro His Pro Leu Ser Ala Gln Arg Pro Gly Thr Arg Arg
             180                 185                 190        
 Ile Gln Glu Val Asp His Trp Glu Asp Glu Ala Gln Leu Pro Val Pro
         195                 200                 205            
 Asp Leu Lys Asp Leu Ala Val Leu His Ala Ile Arg Phe Gln Asp Gly
     210                 215                 220                
 Leu Lys Ser Phe Leu Ala Phe Lys Tyr Ala Met Glu Pro Thr Val Gly
 225                 230                 235                 240
 Gly Thr Ser Ser Phe Pro Cys Arg Glu Pro Tyr Pro
                 245                 250        



      <210> 976
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 976
 Ser Ala Phe Trp Asp Glu Ala Leu Val Thr Ile Leu Ala Val Cys Ile
   1               5                  10                  15    
 Tyr Gly Ile Ala Pro Val Gly Phe Ser Gln His Glu Thr Val Asp Ser
              20                  25                  30        
 Val Leu Arg Asn Arg Gly Val Tyr Glu Asn Val Lys Tyr Val Gln Gln
          35                  40                  45            
 Glu Asn Phe Trp Ile Gly Pro Ser Ser Glu Ala Leu Ile His Leu Gly
      50                  55                  60                
 Ala Lys Phe Ser Pro Cys Met Arg Gln Asp Pro Gln Val His Ser Phe
  65                  70                  75                  80
 Ile Arg Ser Ala Arg Glu Arg Glu Lys His Ser Ala Cys Cys Val Arg
                  85                  90                  95    
 Asn Asp Arg Ser Gly Cys Val Gln Thr Ser Glu Glu Glu Cys Ser Ser
             100                 105                 110        
 Thr Leu Ala Val Trp Val Lys Trp Pro Ile His Pro Ser Ala Pro Glu
         115                 120                 125            
 Leu Ala Gly His Lys Arg Gln Phe Gly Ser Val Cys His Gln Asp Pro
     130                 135                 140                
 Arg Val Cys Asp Glu Pro Ser Ser Glu Asp Pro His Glu Trp Pro Glu
 145                 150                 155                 160
 Asp Ile Thr Lys Trp Pro Ile Cys Thr Lys Asn Ser Ala Gly Asn His
                 165                 170                 175    
 Thr Asn His Pro His Met Asp Cys Val Ile Thr Gly Arg Pro Cys Cys
             180                 185                 190        
 Ile Gly Thr Lys Gly Arg Cys Glu Ile Thr Ser Arg Glu Tyr Cys Asp
         195                 200                 205            
 Phe Met Arg Gly Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val
     210                 215                 220                
 His Cys Met Asp Asp Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu
 225                 230                 235                 240
 Val Pro Asp Gln Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala
                 245                 250                 255    
 Gly Ile Leu His Cys Leu Val Ser Ile Cys Phe Gln Met Thr Val Leu
             260                 265                 270        
 Arg Asp Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Tyr
         275                 280                 285            
 Leu Leu Ser Gly Val Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro
     290                 295                 300                
 Tyr Arg Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Ile Leu Ala
 305                 310                 315                 320
 Cys Leu Phe Val Glu Leu Phe Gln Ser Trp Gln Ile Leu Ala Arg Pro
                 325                 330                 335    
 Trp Arg Ala Phe Phe Lys Leu Leu Ala Val Val Leu Phe Leu Phe Thr
             340                 345                 350        
 Phe Gly Leu Leu Pro Trp Ile Asp Asn Phe Ala His Ile Ser Gly Phe
         355                 360                 365            
 Ile Ser Gly Leu Phe Leu Ser Phe Ala Phe Leu Pro Tyr Ile Ser Phe
     370                 375                 380                
 Gly Lys Phe Asp Leu Tyr Arg Lys Arg Cys Gln Ile Ile Ile Phe Gln
 385                 390                 395                 400
 Val Val Phe Leu Gly Leu Leu Ala Gly Leu Val Val Leu Phe Tyr Val
                 405                 410                 415    
 Tyr Pro Val Arg Cys Glu Trp Cys Glu Phe Leu Thr Cys Ile Pro Phe
             420                 425                 430        
 Thr Asp Lys Phe Cys Glu Lys Tyr Glu Leu Asp Ala Gln Leu His
         435                 440                 445        



      <210> 977
      <211> 447
      <212> PRT
      <213> Homo sapiens


      <400> 977
 Ser Ala Phe Trp Asp Glu Ala Leu Val Thr Ile Leu Ala Val Cys Ile
   1               5                  10                  15    
 Tyr Gly Ile Ala Pro Val Gly Phe Ser Gln His Glu Thr Val Asp Ser
              20                  25                  30        
 Val Leu Arg Asn Arg Gly Val Tyr Glu Asn Val Lys Tyr Val Gln Gln
          35                  40                  45            
 Glu Asn Phe Trp Ile Gly Pro Ser Ser Glu Ala Leu Ile His Leu Gly
      50                  55                  60                
 Ala Lys Phe Ser Pro Cys Met Arg Gln Asp Pro Gln Val His Ser Phe
  65                  70                  75                  80
 Ile Arg Ser Ala Arg Glu Arg Glu Lys His Ser Ala Cys Cys Val Arg
                  85                  90                  95    
 Asn Asp Arg Ser Gly Cys Val Gln Thr Ser Glu Glu Glu Cys Ser Ser
             100                 105                 110        
 Thr Leu Ala Val Trp Val Lys Trp Pro Ile His Pro Ser Ala Pro Glu
         115                 120                 125            
 Leu Ala Gly His Lys Arg Gln Phe Gly Ser Val Cys His Gln Asp Pro
     130                 135                 140                
 Arg Val Cys Asp Glu Pro Ser Ser Glu Asp Pro His Glu Trp Pro Glu
 145                 150                 155                 160
 Asp Ile Thr Lys Trp Pro Ile Cys Thr Lys Asn Ser Ala Gly Asn His
                 165                 170                 175    
 Thr Asn His Pro His Met Asp Cys Val Ile Thr Gly Arg Pro Cys Cys
             180                 185                 190        
 Ile Gly Thr Lys Gly Arg Cys Glu Ile Thr Ser Arg Glu Tyr Cys Asp
         195                 200                 205            
 Phe Met Arg Gly Tyr Phe His Glu Glu Ala Thr Leu Cys Ser Gln Val
     210                 215                 220                
 His Cys Met Asp Asp Val Cys Gly Leu Leu Pro Phe Leu Asn Pro Glu
 225                 230                 235                 240
 Val Pro Asp Gln Phe Tyr Arg Leu Trp Leu Ser Leu Phe Leu His Ala
                 245                 250                 255    
 Gly Ile Leu His Cys Leu Val Ser Ile Cys Phe Gln Met Thr Val Leu
             260                 265                 270        
 Arg Asp Leu Glu Lys Leu Ala Gly Trp His Arg Ile Ala Ile Ile Tyr
         275                 280                 285            
 Leu Leu Ser Gly Val Thr Gly Asn Leu Ala Ser Ala Ile Phe Leu Pro
     290                 295                 300                
 Tyr Arg Ala Glu Val Gly Pro Ala Gly Ser Gln Phe Gly Ile Leu Ala
 305                 310                 315                 320
 Cys Leu Phe Val Glu Leu Phe Gln Ser Trp Gln Ile Leu Ala Arg Pro
                 325                 330                 335    
 Trp Arg Ala Phe Phe Lys Leu Leu Ala Val Val Leu Phe Leu Phe Thr
             340                 345                 350        
 Phe Gly Leu Leu Pro Trp Ile Asp Asn Phe Ala His Ile Ser Gly Phe
         355                 360                 365            
 Ile Ser Gly Leu Phe Leu Ser Phe Ala Phe Leu Pro Tyr Ile Ser Phe
     370                 375                 380                
 Gly Lys Phe Asp Leu Tyr Arg Lys Arg Cys Gln Ile Ile Ile Phe Gln
 385                 390                 395                 400
 Val Val Phe Leu Gly Leu Leu Ala Gly Leu Val Val Leu Phe Tyr Val
                 405                 410                 415    
 Tyr Pro Val Arg Cys Glu Trp Cys Glu Phe Leu Thr Cys Ile Pro Phe
             420                 425                 430        
 Thr Asp Lys Phe Cys Glu Lys Tyr Glu Leu Asp Ala Gln Leu His
         435                 440                 445        



      <210> 978
      <211> 69
      <212> PRT
      <213> Homo sapiens


      <400> 978
 Met Ile Ile Thr Ser Ile Phe Leu Gly Val Ile Thr Val Ile Ile Ile
   1               5                  10                  15    
 Gly Leu Cys Leu Ala Ala Val Thr Tyr Val Asp Glu Asp Glu Asn Glu
              20                  25                  30        
 Ile Leu Glu Leu Ser Ser Asn Lys Thr Phe Phe Ile Met Leu Lys Ile
          35                  40                  45            
 Pro Glu Glu Cys Val Ala Glu Glu Glu Leu Pro His Leu Leu Thr Glu
      50                  55                  60                
 Arg Leu Thr Asp Val
  65                



      <210> 979
      <211> 149
      <212> PRT
      <213> Homo sapiens


      <400> 979
 Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asp Ile Ser Leu Asn
   1               5                  10                  15    
 Ala Leu Ala Leu Met Val Ala Thr Ala Val Leu Thr Leu Ala Pro Leu
              20                  25                  30        
 Leu Leu Ile Cys Leu Ser Tyr Leu Phe Ile Leu Ser Ala Ile Leu Arg
          35                  40                  45            
 Val Pro Ser Ala Ala Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser Ala
      50                  55                  60                
 His Arg Thr Val Val Val Val Phe Tyr Gly Thr Ile Ser Phe Met Tyr
  65                  70                  75                  80
 Phe Lys Pro Lys Ala Lys Asp Pro Asn Val Asp Lys Thr Val Ala Leu
                  85                  90                  95    
 Phe Tyr Gly Val Val Thr Pro Ser Leu Asn Pro Ile Ile Tyr Ser Leu
             100                 105                 110        
 Arg Asn Ala Glu Val Lys Ala Ala Val Leu Thr Leu Leu Arg Gly Gly
         115                 120                 125            
 Leu Leu Ser Arg Lys Ala Ser His Cys Tyr Cys Cys Pro Leu Pro Leu
     130                 135                 140                
 Ser Ala Gly Ile Gly
 145                



      <210> 980
      <211> 341
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(341)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 980
 Val Arg Trp Asn Ser Leu Val Leu Trp Asp Gly Pro Ser Leu Arg Pro
   1               5                  10                  15    
 Xaa Gly Val Thr Ser Gly Pro Phe Pro Gly Trp Ala Phe Leu Thr Gly
              20                  25                  30        
 Thr Pro Pro Leu Ser Arg Gln Ala Trp Pro Pro Leu Pro Pro Pro Thr
          35                  40                  45            
 Ser Ser Thr Ser Gly Pro Ser Ala Ser His Pro Leu Gln Pro Gly Leu
      50                  55                  60                
 Leu Leu His His His Pro Gly Pro Trp Pro Leu Pro Gln Pro Cys Ala
  65                  70                  75                  80
 Pro Ala Pro Arg Ala Gly Tyr Gly Pro Ala Gly Gly Ser Leu Trp Ala
                  85                  90                  95    
 Asp Pro Asp Gly His Ala Val Ala Arg Pro Gly Pro Gly Arg Glu Cys
             100                 105                 110        
 Arg Leu Gly Arg Ala Ala Leu His Ala Pro Leu Met Ala Cys Trp Pro
         115                 120                 125            
 Gly Thr Pro Ser Pro Ser Pro Cys Pro Met Pro Ala Trp Xaa Ser Xaa
     130                 135                 140                
 Pro Pro Thr Met Leu Pro Ser Ser Ser Phe Thr Leu Ser Ala Leu Arg
 145                 150                 155                 160
 Ser Pro Val Pro Lys Thr Asp Xaa Leu Gly Ser Leu Lys Gly Arg Cys
                 165                 170                 175    
 Ser Gly His Ser Pro Pro Ala Arg Thr Trp Ala Ser Gln Pro Ser Pro
             180                 185                 190        
 Ala Xaa Glu Ile Pro Ser Ala Ala Lys Leu Pro Asp Ala Cys Leu Gln
         195                 200                 205            
 Ala Pro Leu Pro Pro Ser Leu Leu Ala Glu Asp Val Xaa Gly Arg Phe
     210                 215                 220                
 Ala Glu Phe Gln Val His Tyr Trp Val Pro Ala Ala Phe Pro Arg Phe
 225                 230                 235                 240
 Xaa Leu Gln Ile Pro Gly Ser Ser Ala Arg Pro Thr Trp Ser Pro Pro
                 245                 250                 255    
 Ser His Gln Pro Ala Ser Met Phe Thr Val Gly Pro Thr Ala Cys Pro
             260                 265                 270        
 Pro Pro Ala Ala Ala Leu Asn Pro Phe Ser Leu Trp Val Trp Asn Arg
         275                 280                 285            
 Arg Cys Cys Cys Tyr Arg Arg Arg Gly Leu Gly Glu Gly His His Cys
     290                 295                 300                
 Asp Lys Pro Ser Arg Leu Met Thr Ala Glu Gly Ser Leu Ser Leu Pro
 305                 310                 315                 320
 Met Asp Gln Ala Trp Cys Pro Val Gly Pro Ser Met Ala Leu Trp Trp
                 325                 330                 335    
 Gly Ala Pro Gly Gly
             340    



      <210> 981
      <211> 771
      <212> PRT
      <213> Homo sapiens


      <400> 981
 Ser Ile Arg Cys Leu Asp Leu Ser Met Ser Thr Val Glu Glu Asp Ser
   1               5                  10                  15    
 Asp Thr Val Thr Val Glu Thr Val Asn Ser Val Thr Leu Thr Gln Asp
              20                  25                  30        
 Thr Glu Gly Asn Leu Ile Leu His Cys Pro Gln Asn Glu Ala Asp Glu
          35                  40                  45            
 Ile Asp Ser Glu Asp Ser Ile Glu Pro Pro His Lys Arg Leu Cys Leu
      50                  55                  60                
 Ser Ser Glu Asp Asp Gln Ser Ile Asp Asp Ser Thr Pro Cys Ile Ser
  65                  70                  75                  80
 Val Val Ala Leu Pro Leu Ser Glu Asn Asp Gln Ser Phe Glu Val Thr
                  85                  90                  95    
 Met Thr Ala Thr Thr Glu Val Ala Asp Asp Glu Val Thr Glu Gly Thr
             100                 105                 110        
 Val Thr Gln Ile Gln Ile Leu Gln Asn Glu Gln Leu Asp Glu Ile Ser
         115                 120                 125            
 Pro Leu Gly Asn Glu Glu Val Ser Ala Val Ser Gln Ala Trp Phe Thr
     130                 135                 140                
 Thr Lys Glu Asp Lys Asp Ser Leu Thr Asn Lys Gly His Lys Trp Lys
 145                 150                 155                 160
 Gln Gly Met Trp Ser Lys Glu Glu Ile Asp Ile Leu Met Asn Asn Ile
                 165                 170                 175    
 Glu Arg Tyr Leu Lys Ala Arg Gly Ile Lys Asp Ala Thr Glu Ile Ile
             180                 185                 190        
 Phe Glu Met Ser Lys Asp Glu Arg Lys Asp Phe Tyr Arg Thr Ile Ala
         195                 200                 205            
 Trp Gly Leu Asn Arg Pro Leu Phe Ala Val Tyr Arg Arg Val Leu Arg
     210                 215                 220                
 Met Tyr Asp Asp Arg Asn His Val Gly Lys Tyr Thr Pro Glu Glu Ile
 225                 230                 235                 240
 Glu Lys Leu Lys Glu Leu Arg Ile Lys His Gly Asn Asp Trp Ala Thr
                 245                 250                 255    
 Ile Gly Ala Ala Leu Gly Arg Ser Ala Ser Ser Val Lys Asp Arg Cys
             260                 265                 270        
 Arg Leu Met Lys Asp Thr Cys Asn Thr Gly Lys Trp Thr Glu Glu Glu
         275                 280                 285            
 Glu Lys Arg Leu Ala Glu Val Val His Glu Leu Thr Ser Thr Glu Pro
     290                 295                 300                
 Gly Asp Ile Val Thr Gln Gly Val Ser Trp Ala Ala Val Ala Glu Arg
 305                 310                 315                 320
 Val Gly Thr Arg Ser Glu Lys Gln Cys Arg Ser Lys Trp Leu Asn Tyr
                 325                 330                 335    
 Leu Asn Trp Lys Gln Ser Gly Gly Thr Glu Trp Thr Lys Glu Asp Glu
             340                 345                 350        
 Ile Asn Leu Ile Leu Arg Ile Ala Glu Leu Asp Val Ala Asp Glu Asn
         355                 360                 365            
 Asp Ile Asn Trp Asp Leu Leu Ala Glu Gly Trp Ser Ser Val Arg Ser
     370                 375                 380                
 Pro Gln Trp Leu Arg Ser Lys Trp Trp Thr Ile Lys Arg Gln Ile Ala
 385                 390                 395                 400
 Asn His Lys Asp Val Ser Phe Pro Val Leu Ile Lys Gly Leu Lys Gln
                 405                 410                 415    
 Leu His Glu Asn Gln Lys Asn Asn Pro Thr Leu Leu Glu Asn Lys Ser
             420                 425                 430        
 Gly Ser Gly Val Pro Asn Ser Asn Thr Asn Ser Ser Val Gln His Val
         435                 440                 445            
 Gln Ile Arg Val Ala Arg Leu Glu Asp Asn Thr Ala Ile Ser Ser Ser
     450                 455                 460                
 Pro Met Ala Ala Leu Gln Ile Pro Val Gln Ile Thr His Val Ser Ser
 465                 470                 475                 480
 Ala Asp Ser Pro Ala Thr Val Asp Ser Glu Thr Ile Thr Leu Asn Ser
                 485                 490                 495    
 Gly Thr Leu Gln Thr Phe Glu Ile Leu Pro Ser Phe His Leu Gln Pro
             500                 505                 510        
 Thr Gly Thr Pro Gly Thr Tyr Leu Leu Gln Thr Ser Ser Ser Gln Gly
         515                 520                 525            
 Leu Pro Leu Thr Leu Thr Ala Ser Pro Thr Val Thr Leu Thr Ala Ala
     530                 535                 540                
 Ala Pro Cys Ala Ser Pro Glu Gln Ile Ile Val His Ala Leu Ser Pro
 545                 550                 555                 560
 Glu His Leu Leu Asn Thr Ser Asp Asn Val Thr Val Gln Cys His Thr
                 565                 570                 575    
 Pro Arg Val Ile Ile Gln Thr Val Ala Thr Glu Asp Ile Thr Ser Ser
             580                 585                 590        
 Ile Ser Gln Ala Gln Glu Leu Thr Val Asp Ser Asp Ile Gln Phe Ile
         595                 600                 605            
 Leu Asp Phe Pro Glu Pro Pro Asp Ala Leu Glu Ala Asn Thr Phe Pro
     610                 615                 620                
 Asp Glu Ile His His Pro Lys Met Thr Val Glu Pro Ser Phe Asn Asp
 625                 630                 635                 640
 Ala His Val Ser Lys Phe Ser Asp Gln Asn Ser Thr Glu Leu Met Asn
                 645                 650                 655    
 Ser Val Met Val Arg Thr Glu Lys Glu Ile Ser Asp Thr Asp Leu Lys
             660                 665                 670        
 Gln Glu Glu Ser Pro Ser Asp Leu Ala Ser Ala Tyr Val Thr Glu Gly
         675                 680                 685            
 Leu Glu Ser Pro Thr Ile Glu Glu Gln Val Asp Gln Thr Ile Asp Asp
     690                 695                 700                
 Glu Thr Ile Leu Ile Val Pro Ser Pro His Gly Phe Ile Gln Ala Ser
 705                 710                 715                 720
 Asp Val Ile Asp Thr Glu Ser Val Leu Pro Leu Thr Thr Leu Thr Asp
                 725                 730                 735    
 Pro Ile Leu Gln His His Gln Glu Glu Ser Asn Ile Ile Gly Ser Ser
             740                 745                 750        
 Leu Gly Ser Pro Val Ser Glu Asp Ser Lys Asp Val Glu Asp Leu Val
         755                 760                 765            
 Asn Cys His
     770    



      <210> 982
      <211> 151
      <212> PRT
      <213> Homo sapiens


      <400> 982
 Phe Phe Phe Phe Glu Thr Gln Phe His Ser Leu Pro Arg Leu Glu Cys
   1               5                  10                  15    
 Ser Gly Ala Ile Ser Ala His Cys Asn Phe Cys Leu Leu Gly Ser Ser
              20                  25                  30        
 Ser Ser Pro Ala Ser Ala Ser Gln Val Val Gly Ile Thr Gly Met His
          35                  40                  45            
 His His Ala Trp Ile Ile Phe Val Leu Phe Leu Val Glu Thr Gly Phe
      50                  55                  60                
 His His Val Gly His Ala Gly Phe Glu Leu Leu Thr Thr Cys Gly Pro
  65                  70                  75                  80
 Pro Thr Leu Ala Ser Ile Met Cys Ile Leu Val Tyr Leu Leu Val Phe
                  85                  90                  95    
 Gln His Leu Val Ser Leu Lys Asn Leu Lys Gly Gln Asn Ala Ser Phe
             100                 105                 110        
 Tyr Phe Ser Pro Phe Gly Gln His Leu Ser Gly Phe Val Lys Cys Ser
         115                 120                 125            
 Ile Trp Cys Cys Gly Ser Leu Ser Gly Leu Glu Gly His Phe Leu Pro
     130                 135                 140                
 Pro His Ser Pro Pro Leu His
 145                 150    



      <210> 983
      <211> 65
      <212> PRT
      <213> Homo sapiens


      <400> 983
 Met Ala Ala Gly Val Ser Ser Val Leu Leu Leu Leu Phe Thr Leu Met
   1               5                  10                  15    
 Glu Ser Gly Leu Lys His Arg Val Trp Glu Ser Trp Gln Leu Phe Thr
              20                  25                  30        
 Ser Trp Leu Ala Phe Cys Ser Pro Ser Phe Ser Val Val Phe Thr Cys
          35                  40                  45            
 Ser Tyr Ser Leu Ser Ser Trp Gly Leu Lys Gly Ile Ser Ser Arg Thr
      50                  55                  60                
 Arg
  65



      <210> 984
      <211> 391
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(391)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 984
 Ser Lys Lys Arg Lys Arg Gln Glu Glu Lys His Val Cys Lys Lys His
   1               5                  10                  15    
 Asn Gln Val Leu Thr Phe Phe Cys Gln Lys Asp Leu Xaa Leu Leu Cys
              20                  25                  30        
 Pro Arg Cys Ser Leu Ser Thr Asp His Gln His His Cys Val Trp Pro
          35                  40                  45            
 Ile Lys Lys Ala Ala Ser Tyr His Arg Lys Lys Leu Glu Glu Tyr Asn
      50                  55                  60                
 Ala Pro Trp Lys Glu Arg Val Glu Leu Ile Glu Lys Val Ile Thr Met
  65                  70                  75                  80
 Gln Thr Arg Lys Ser Leu Glu Leu Lys Lys Lys Val Lys His Arg Ala
                  85                  90                  95    
 Glu Glu Val Lys Ser Glu Phe Glu Gln Leu Arg Leu Phe Leu Gln Asn
             100                 105                 110        
 Glu Gln Glu Thr Val Leu Arg Gln Leu Gln Asp Glu Glu Met Asp Ile
         115                 120                 125            
 Leu Ala Gln Leu Asn Glu Ser Leu Thr Lys Phe Ser Asp Tyr Thr Ser
     130                 135                 140                
 Ser Leu Lys Tyr Leu Leu Lys Glu Ile Glu Ser Ile Tyr Val Lys Ser
 145                 150                 155                 160
 Glu Leu Glu Leu Leu Ala Asn Val Lys Asp Ile Tyr His Arg Tyr Lys
                 165                 170                 175    
 Asn Leu Lys Phe Pro Glu Leu Phe Leu Phe Lys Leu Lys Lys Tyr Gly
             180                 185                 190        
 Tyr His Leu Pro Pro Gln Tyr Ser Gly Leu Asp Xaa Ile Ile Lys Arg
         195                 200                 205            
 Phe Gln Val Asp Val Ile Leu Asp Pro Glu Thr Ala His Arg Lys Leu
     210                 215                 220                
 Ile Val Ser Glu Asp Arg Lys Thr Val Arg Tyr Gly Asn Thr Thr Gln
 225                 230                 235                 240
 Asn Val Pro His Asn Pro Arg Arg Phe Tyr Leu Leu Pro Ala Val Leu
                 245                 250                 255    
 Gly Ser Lys Gly Tyr Ser Cys Gly Arg Gln Tyr Trp Glu Val Glu Val
             260                 265                 270        
 Lys Asp Lys Pro Glu Trp Ile Leu Gly Val Cys Asn Asp Cys Leu Pro
         275                 280                 285            
 Arg Arg Arg Lys Ser Gln Pro Ile Leu Val Gln Asp Gly Leu Trp Gly
     290                 295                 300                
 Ile Trp Arg Ser Ser Gln Asn Asn Tyr Ile Val Leu Gly His Arg Glu
 305                 310                 315                 320
 Ile Ile Leu Leu Pro Gln Val Ile Pro Ser Lys Ile Gly Ile Phe Leu
                 325                 330                 335    
 Asp Tyr Glu Met Asn Glu Val Ser Phe Tyr Asn Leu Asn Asp Arg Ser
             340                 345                 350        
 Leu Leu Tyr Thr Phe Asn Asp Asn Phe Thr Gly Ala Leu Trp Pro Tyr
         355                 360                 365            
 Phe Tyr Thr Gly Thr Asp Ser Lys Pro Leu Lys Ile Ser Thr Val Thr
     370                 375                 380                
 Asp Ser Val Phe Ser Phe Thr
 385                 390    



      <210> 985
      <211> 139
      <212> PRT
      <213> Homo sapiens


      <400> 985
 Met Glu Thr Phe Pro Leu Leu Leu Leu Ser Leu Gly Leu Val Leu Ala
   1               5                  10                  15    
 Glu Ala Ser Glu Ser Thr Met Lys Ile Ile Lys Glu Glu Phe Thr Asp
              20                  25                  30        
 Glu Glu Met Gln Tyr Asp Met Ala Lys Ser Gly Gln Glu Lys Gln Thr
          35                  40                  45            
 Ile Glu Ile Leu Met Asn Pro Ile Leu Leu Val Lys Asn Thr Ser Leu
      50                  55                  60                
 Ser Met Ser Lys Asp Asp Met Ser Ser Thr Leu Leu Thr Phe Arg Ser
  65                  70                  75                  80
 Leu His Tyr Asn Asp Pro Lys Gly Asn Ser Ser Gly Asn Asp Lys Glu
                  85                  90                  95    
 Cys Cys Asn Asp Met Thr Val Trp Arg Lys Val Ser Glu Ala Asn Gly
             100                 105                 110        
 Ser Cys Lys Trp Ser Asn Asn Phe Ile Arg Ser Ser Thr Glu Val Met
         115                 120                 125            
 Arg Arg Val His Arg Ala Pro Ser Cys Glu Phe
     130                 135                



      <210> 986
      <211> 113
      <212> PRT
      <213> Homo sapiens


      <400> 986
 Met Ala Pro Pro Gly Leu Arg Arg Gly Trp Phe Thr Ser Arg Leu Glu
   1               5                  10                  15    
 Leu Tyr Ser Leu Gln His Ser Leu Ser Thr Glu Pro Ala Val Val Leu
              20                  25                  30        
 Gly Leu Ala Leu Ala Leu Ala Phe Ala Thr Leu Leu Leu Gly Thr Trp
          35                  40                  45            
 Asn Val Pro Leu Ser Leu Phe Ser Val Ala Ala Val Ala Gly Thr Val
      50                  55                  60                
 Leu Leu Thr Val Gly Leu Leu Gly Leu Leu Glu Trp Gln Leu Asn Thr
  65                  70                  75                  80
 Ala Glu Ala Leu Phe Leu Ser Ala Ser Val Gly Leu Ser Val Asp Phe
                  85                  90                  95    
 Thr Val Asn Tyr Cys Ile Ser Tyr His Leu Cys Pro His Pro Asp Arg
             100                 105                 110        
 Leu
    



      <210> 987
      <211> 141
      <212> PRT
      <213> Homo sapiens

      <220>
      <221> misc_feature
      <222> (1)...(141)
      <223> Xaa = any amino acid or symbol as shown in the table 8 as set forth in Example 2


      <400> 987
 Leu Ser Met Leu Ser Thr Ile Ser Thr Glu His Arg Leu Ser Val Leu
   1               5                  10                  15    
 Trp Pro Ile Trp Tyr Cys Cys His Cys Pro Thr His Leu Ser Ala Val
              20                  25                  30        
 Met Cys Val Leu Leu Trp Ala Leu Ser Leu Leu Gln Ser Ile Leu Glu
          35                  40                  45            
 Trp Met Phe Cys Ser Phe Leu Phe Ser Asp Val Asp Ser Asp Asn Trp
      50                  55                  60                
 Cys Gln Ile Leu Asp Phe Leu Thr Ala Val Trp Leu Ile Phe Leu Ile
  65                  70                  75                  80
 Leu Val Leu Cys Gly Phe Thr Leu Val Leu Leu Val Arg Ile Ile Cys
                  85                  90                  95    
 Gly Ser Gln Lys Met Pro Leu Thr Arg Leu Tyr Val Thr Ile Leu Leu
             100                 105                 110        
 Thr Gly Leu Val Phe Leu Phe Cys Ser Leu Pro Leu Ser Ile Gln Xaa
         115                 120                 125            
 Phe Leu Leu Tyr Trp Ile Glu Lys Asp Leu Asp Asp Leu
     130                 135                 140    



      <210> 988
      <211> 164
      <212> PRT
      <213> Homo sapiens


      <400> 988
 Val Arg Asn Thr Arg Val Asp Asp Phe Val Ala Pro Ser Ala Gly Gly
   1               5                  10                  15    
 Trp Glu Arg Ala Glu Arg Gly Arg Gly Ala Ala Ala Arg Pro Ala Thr
              20                  25                  30        
 Gly Pro Pro Pro Arg Arg Ile Gly Pro Leu Tyr Gly Met Trp Leu Val
          35                  40                  45            
 Thr Phe Leu Leu Leu Leu Asp Ser Leu His Lys Ala Arg Pro Glu Asp
      50                  55                  60                
 Val Gly Thr Ser Leu Tyr Phe Val Asn Asp Ser Leu Gln Gln Val Thr
  65                  70                  75                  80
 Phe Ser Ser Ser Val Gly Val Val Val Pro Cys Pro Ala Ala Gly Ser
                  85                  90                  95    
 Pro Ser Ala Ala Leu Arg Trp Tyr Leu Ala Thr Gly Asp Asp Ile Tyr
             100                 105                 110        
 Asp Val Pro His Ile Arg His Val His Ala Asn Gly Thr Leu Gln Leu
         115                 120                 125            
 Tyr Pro Phe Ser Pro Ser Ala Phe Asn Ser Phe Ile His Asp Asn Asp
     130                 135                 140                
 Tyr Phe Cys Thr Ala Glu Asn Ala Ala Gly Lys Ile Arg Ser Pro Asn
 145                 150                 155                 160
 Ile Arg Val Lys
                



      <210> 989
      <211> 74
      <212> PRT
      <213> Homo sapiens


      <400> 989
 Asn Asp Ser Leu Val Pro Met Ser Ser Trp Arg Ser Cys Ala Arg Ala
   1               5                  10                  15    
 Pro Ser Ser Glu Ser Ala Trp Arg Arg Ser Ala Ala Thr Arg Arg Ser
              20                  25                  30        
 Arg Lys Cys Leu Arg Thr Lys Arg Lys Arg Trp Ser Ser Gly Lys Gly
          35                  40                  45            
 Thr Gln Met Gln Ser Thr Leu Ser Glu Thr Pro Arg Arg Ala Gln Met
      50                  55                  60                
 Pro Cys Met Trp Trp Tyr Pro Phe Trp Gly
  65                  70                



      <210> 990
      <211> 158
      <212> PRT
      <213> Homo sapiens


      <400> 990
 Val Ile Ser Phe Gln Ile Ile Thr Asp Thr Ile Met Asp Ser Ser Thr
   1               5                  10                  15    
 Ala His Ser Pro Val Phe Leu Val Phe Pro Pro Glu Ile Thr Ala Ser
              20                  25                  30        
 Glu Tyr Glu Ser Thr Glu Leu Ser Ala Thr Thr Phe Ser Thr Gln Ser
          35                  40                  45            
 Pro Leu Gln Lys Leu Phe Ala Arg Lys Met Lys Ile Leu Gly Thr Ile
      50                  55                  60                
 Gln Ile Leu Phe Gly Ile Met Thr Phe Ser Phe Gly Val Ile Phe Leu
  65                  70                  75                  80
 Phe Thr Leu Leu Lys Pro Tyr Pro Arg Phe Pro Phe Ile Phe Leu Ser
                  85                  90                  95    
 Gly Tyr Pro Phe Trp Gly Ser Val Leu Phe Ile Asn Ser Gly Ala Phe
             100                 105                 110        
 Leu Ile Ala Val Lys Arg Lys Thr Thr Glu Thr Leu Ile Ile Leu Ser
         115                 120                 125            
 Arg Ile Met Asn Phe Leu Ser Ala Leu Gly Ala Ile Ala Gly Ile Ile
     130                 135                 140                
 Leu Leu Thr Phe Glu Phe His Pro Arg Ser Lys Leu His Leu
 145                 150                 155            



      <210> 991
      <211> 122
      <212> PRT
      <213> Homo sapiens


      <400> 991
 Asp Phe Ala Val Phe Leu Thr Ile Leu Cys Met Val Leu Ile Asp Tyr
   1               5                  10                  15    
 Ala Ile Gly Ile Pro Ser Pro Lys Leu Gln Val Pro Ser Val Phe Lys
              20                  25                  30        
 Pro Thr Arg Asp Asp Arg Gly Trp Phe Val Thr Pro Leu Gly Pro Asn
          35                  40                  45            
 Pro Trp Trp Thr Val Ile Ala Ala Ile Ile Pro Ala Leu Leu Cys Thr
      50                  55                  60                
 Ile Leu Ile Phe Met Asp Gln Gln Ile Thr Ala Val Ile Ile Asn Arg
  65                  70                  75                  80
 Lys Glu His Lys Leu Lys Lys Gly Cys Gly Tyr His Leu Asp Leu Leu
                  85                  90                  95    
 Met Val Ala Val Met Leu Gly Val Cys Ser Ile Met Gly Leu Pro Trp
             100                 105                 110        
 Phe Val Ala Ala Thr Val Leu Ser Ile Thr
         115                 120        



      <210> 992
      <211> 156
      <212> PRT
      <213> Homo sapiens


      <400> 992
 Arg Asn Ser Trp Val Asp Asp Phe Val Gly Asp Lys Ser Arg Pro Pro
   1               5                  10                  15    
 Ala Pro Glu Leu Gly Ser Pro Gly Ala Val Arg Pro Arg Val Gly Ser
              20                  25                  30        
 Cys Ala Pro Gly Pro Met Glu Leu Arg Val Ser Asn Thr Ser Cys Glu
          35                  40                  45            
 Asn Gly Ser Leu Leu His Leu Tyr Cys Ser Ser Gln Glu Val Leu Cys
      50                  55                  60                
 Gln Ile Val Asn Asp Leu Ser Pro Glu Val Pro Ser Asn Ala Thr Phe
  65                  70                  75                  80
 His Ser Trp Gln Glu Arg Ile Arg Gln Asn Tyr Gly Phe Tyr Ile Gly
                  85                  90                  95    
 Leu Gly Leu Ala Phe Leu Ser Ser Phe Leu Ile Gly Ser Ser Val Ile
             100                 105                 110        
 Leu Lys Lys Lys Gly Leu Leu Arg Leu Val Ala Met Gly Ala Thr Arg
         115                 120                 125            
 Ala Val Asp Gly Gly Phe Gly Tyr Leu Lys Asp Ala Met Trp Trp Ala
     130                 135                 140                
 Gly Phe Leu Thr Met Ala Ala Gly Glu Val Ala Asn
 145                 150                 155    


